Meta-SNP - Meta-predictor of disease causing variants

Meta-SNP
Meta-predictor of disease causing variants

Sequence File: NEK2_HUMAN.seq
Alignment File: NEK2_HUMAN.seq.blast
Output File: output.txt


Mutation	PANTHER	PhD-SNP	SIFT	SNAP	Meta-SNP	RI

M1V	NA	Neutral	Disease	Neutral	Neutral	4
	-	0.172	0.000	0.440	0.291

P2L	NA	Neutral	Disease	Neutral	Neutral	6
	-	0.279	0.020	0.445	0.212

P2T	NA	Neutral	Disease	Neutral	Neutral	6
	-	0.229	0.020	0.410	0.207

R4L	NA	Neutral	Neutral	Neutral	Neutral	6
	-	0.356	0.070	0.480	0.184

R4W	NA	Neutral	Disease	Disease	Neutral	4
	-	0.353	0.000	0.550	0.303

E6D	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.357	0.063	0.490	0.195	0.273

D7V	Disease	Neutral	Disease	Disease	Disease	3
	0.857	0.443	0.040	0.605	0.669

Y8C	Disease	Disease	Disease	Disease	Disease	8
	0.996	0.817	0.000	0.760	0.879

E9V	Disease	Neutral	Neutral	Neutral	Disease	2
	0.551	0.461	0.070	0.465	0.608

V10G	Disease	Disease	Neutral	Neutral	Disease	4
	0.931	0.519	0.060	0.480	0.714

L11S	Disease	Disease	Disease	Disease	Disease	5
	0.913	0.548	0.000	0.575	0.761

Y12H	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.401	0.227	0.110	0.350	0.429

T13P	Disease	Disease	Neutral	Neutral	Disease	0
	0.668	0.521	0.190	0.365	0.521

T13S	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.454	0.180	0.470	0.320	0.316

I14F	Disease	Disease	Disease	Disease	Disease	7
	0.964	0.794	0.000	0.815	0.859

I14T	Disease	Disease	Disease	Disease	Disease	7
	0.973	0.738	0.000	0.780	0.867

G15D	Disease	Disease	Disease	Disease	Disease	7
	0.903	0.885	0.010	0.875	0.856

T16A	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.426	0.170	0.410	0.405	0.302

G17D	Disease	Disease	Disease	Disease	Disease	8
	0.998	0.897	0.000	0.915	0.890

S18P	Disease	Disease	Disease	Disease	Disease	7
	0.952	0.833	0.000	0.725	0.844

G20S	Disease	Disease	Neutral	Disease	Disease	1
	0.814	0.588	0.070	0.555	0.572

R21C	Disease	Disease	Disease	Disease	Disease	2
	0.789	0.675	0.050	0.520	0.602

R21H	Disease	Neutral	Neutral	Neutral	Disease	2
	0.834	0.293	0.060	0.435	0.610

C22Y	Disease	Disease	Disease	Disease	Disease	7
	0.925	0.723	0.000	0.730	0.846

Q23R	Disease	Neutral	Neutral	Neutral	Neutral	2
	0.538	0.218	0.470	0.115	0.421

K24M	Disease	Neutral	Disease	Disease	Disease	5
	0.960	0.476	0.030	0.555	0.733

K24Q	Disease	Neutral	Neutral	Neutral	Disease	3
	0.751	0.383	0.210	0.280	0.657

I25T	Disease	Neutral	Disease	Disease	Disease	3
	0.723	0.345	0.000	0.510	0.655

R26L	Disease	Disease	Neutral	Disease	Disease	1
	0.628	0.728	0.080	0.505	0.558

R26W	Disease	Disease	Disease	Disease	Disease	7
	0.981	0.806	0.000	0.615	0.826

R27K	Disease	Neutral	Neutral	Neutral	Disease	3
	0.766	0.380	0.070	0.265	0.656

K28R	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.591	0.154	0.340	0.300	0.375

S29C	Disease	Neutral	Disease	Neutral	Disease	2
	0.975	0.292	0.010	0.475	0.593

S29R	Disease	Neutral	Neutral	Neutral	Neutral	2
	0.598	0.212	0.150	0.400	0.415

S29T	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.687	0.082	0.410	0.220	0.373

D30V	Disease	Disease	Disease	Disease	Disease	5
	0.917	0.652	0.000	0.620	0.767

G31S	Disease	Neutral	Neutral	Neutral	Disease	2
	0.659	0.454	0.070	0.330	0.620

K32N	Disease	Neutral	Neutral	Neutral	Disease	3
	0.840	0.376	0.080	0.305	0.643

K32R	Disease	Neutral	Neutral	Neutral	Neutral	5
	0.529	0.140	0.200	0.205	0.275

I33M	Disease	Neutral	Neutral	Neutral	Neutral	1
	0.614	0.212	0.080	0.175	0.451

I33T	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.486	0.258	0.140	0.230	0.409

I33V	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.484	0.097	0.490	0.150	0.300

L34I	Disease	Neutral	Disease	Neutral	Disease	2
	0.715	0.293	0.050	0.450	0.615

W36C	Disease	Neutral	Neutral	Neutral	Disease	3
	0.886	0.495	0.350	0.315	0.652

W36G	Disease	Neutral	Neutral	Disease	Disease	3
	0.918	0.387	0.310	0.505	0.662

L39F	Disease	Disease	Disease	Disease	Disease	6
	0.931	0.570	0.000	0.535	0.778

L39H	Disease	Disease	Disease	Disease	Disease	7
	0.988	0.607	0.000	0.635	0.854

L39R	Disease	Disease	Disease	Disease	Disease	8
	0.979	0.863	0.000	0.680	0.875

D40G	Disease	Disease	Neutral	Neutral	Neutral	1
	0.662	0.575	0.060	0.445	0.471

D40Y	Disease	Disease	Disease	Disease	Disease	6
	0.929	0.733	0.030	0.580	0.787

Y41C	Disease	Disease	Disease	Disease	Disease	3
	0.792	0.577	0.010	0.530	0.634

G42D	Neutral	Disease	Neutral	Neutral	Neutral	1
	0.498	0.591	0.160	0.410	0.456

S43F	NA	Neutral	Neutral	Neutral	Neutral	6
	-	0.447	0.080	0.410	0.209

M44L	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.438	0.279	0.330	0.395	0.445

M44T	Disease	Disease	Disease	Disease	Disease	5
	0.869	0.642	0.000	0.705	0.745

M44V	Disease	Disease	Disease	Disease	Disease	2
	0.834	0.543	0.010	0.675	0.615

T45S	Disease	Neutral	Neutral	Neutral	Neutral	6
	0.523	0.088	1.000	0.100	0.217

E46G	Disease	Neutral	Neutral	Neutral	Disease	3
	0.838	0.353	0.080	0.370	0.639

A47T	Disease	Neutral	Neutral	Neutral	Neutral	5
	0.525	0.174	0.200	0.230	0.271

K49Q	Disease	Neutral	Disease	Neutral	Disease	3
	0.781	0.393	0.040	0.450	0.651

Q50E	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.495	0.237	0.600	0.190	0.377

Q50H	Disease	Neutral	Neutral	Neutral	Disease	3
	0.909	0.417	0.050	0.275	0.656

M51I	Disease	Neutral	Neutral	Neutral	Neutral	0
	0.810	0.228	0.230	0.290	0.478

M51K	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.498	0.307	0.890	0.305	0.267

M51R	Disease	Neutral	Neutral	Neutral	Neutral	0
	0.553	0.372	0.560	0.260	0.498

M51T	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.416	0.235	0.580	0.315	0.436

V53A	Disease	Neutral	Neutral	Neutral	Disease	1
	0.687	0.286	0.180	0.330	0.539

V53I	Disease	Neutral	Neutral	Neutral	Neutral	5
	0.519	0.134	0.310	0.175	0.271

E55K	Disease	Disease	Disease	Disease	Disease	8
	0.987	0.883	0.000	0.830	0.891

V56A	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.514	0.288	0.240	0.230	0.373

N57S	Disease	Neutral	Neutral	Neutral	Neutral	5
	0.501	0.149	0.220	0.215	0.230

L58S	Disease	Disease	Disease	Disease	Disease	6
	0.961	0.703	0.000	0.535	0.822

R60C	Disease	Disease	Disease	Disease	Disease	6
	0.962	0.633	0.010	0.510	0.804

R60H	Disease	Neutral	Disease	Neutral	Disease	3
	0.869	0.426	0.020	0.435	0.660

E61G	Disease	Neutral	Neutral	Neutral	Neutral	2
	0.825	0.113	0.060	0.450	0.404

L62R	Disease	Disease	Disease	Disease	Disease	7
	0.994	0.849	0.000	0.760	0.866

H64L	Disease	Disease	Disease	Disease	Disease	8
	0.992	0.906	0.000	0.770	0.875

H64Y	Disease	Disease	Disease	Disease	Disease	7
	0.992	0.870	0.010	0.730	0.833

P65L	Disease	Disease	Disease	Disease	Disease	6
	0.952	0.877	0.010	0.560	0.808

P65S	Disease	Disease	Disease	Disease	Disease	4
	0.907	0.829	0.020	0.565	0.718

N66S	Disease	Disease	Disease	Disease	Disease	6
	0.932	0.773	0.020	0.635	0.784

I67V	Disease	Neutral	Neutral	Neutral	Disease	2
	0.710	0.411	0.130	0.380	0.576

V68I	Disease	Neutral	Neutral	Neutral	Neutral	5
	0.515	0.102	0.330	0.310	0.274

R69C	Disease	Disease	Disease	Disease	Disease	3
	0.814	0.619	0.020	0.590	0.655

R69H	Disease	Neutral	Disease	Neutral	Disease	2
	0.676	0.335	0.010	0.495	0.606

Y70C	Disease	Disease	Disease	Disease	Disease	7
	0.997	0.790	0.040	0.575	0.842

Y71C	Disease	Disease	Neutral	Neutral	Disease	3
	0.872	0.684	0.080	0.470	0.627

D72H	Disease	Neutral	Neutral	Neutral	Disease	2
	0.717	0.471	0.110	0.435	0.609

R73L	Disease	Disease	Neutral	Disease	Disease	0
	0.699	0.525	0.180	0.510	0.505

R73W	Disease	Disease	Neutral	Neutral	Disease	3
	0.882	0.604	0.100	0.390	0.631

I74V	Disease	Neutral	Neutral	Neutral	Disease	1
	0.609	0.249	0.180	0.285	0.554

I75T	Disease	Neutral	Neutral	Neutral	Disease	2
	0.824	0.293	0.150	0.445	0.612

I75V	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.418	0.062	0.560	0.235	0.260

D76G	Disease	Disease	Neutral	Neutral	Disease	1
	0.704	0.718	0.090	0.485	0.546

D76N	Disease	Neutral	Neutral	Neutral	Disease	1
	0.622	0.500	0.090	0.350	0.525

R77Q	NA	Neutral	Neutral	Neutral	Neutral	7
	-	0.224	0.130	0.315	0.137

R77W	NA	Disease	Disease	Disease	Disease	4
	-	0.713	0.000	0.550	0.710

T78I	NA	Neutral	Neutral	Neutral	Neutral	7
	-	0.421	0.160	0.345	0.172

T78S	NA	Neutral	Neutral	Neutral	Neutral	7
	-	0.248	0.790	0.180	0.172

N79S	Disease	Neutral	Neutral	Neutral	Disease	1
	0.581	0.240	0.650	0.235	0.561

L82V	Disease	Neutral	Neutral	Neutral	Disease	3
	0.794	0.431	0.070	0.320	0.650

I84T	Disease	Disease	Disease	Disease	Disease	6
	0.931	0.841	0.010	0.640	0.791

I84V	Disease	Neutral	Disease	Disease	Disease	3
	0.906	0.480	0.030	0.620	0.656

M86T	Disease	Disease	Neutral	Disease	Disease	1
	0.756	0.675	0.080	0.545	0.530

E87D	Disease	Neutral	Neutral	Neutral	Disease	2
	0.736	0.466	0.110	0.465	0.594

E87K	Disease	Disease	Disease	Disease	Disease	6
	0.974	0.863	0.010	0.765	0.824

E87V	Disease	Disease	Disease	Disease	Disease	6
	0.992	0.853	0.000	0.710	0.825

Y88C	Disease	Disease	Disease	Disease	Disease	5
	0.908	0.913	0.020	0.640	0.740

C89Y	Disease	Disease	Disease	Disease	Disease	5
	0.879	0.930	0.020	0.685	0.757

E90D	Disease	Neutral	Neutral	Neutral	Neutral	1
	0.567	0.188	0.660	0.180	0.455

E90K	Disease	Disease	Neutral	Neutral	Disease	2
	0.797	0.621	0.140	0.370	0.576

G91E	Disease	Disease	Neutral	Disease	Disease	3
	0.840	0.886	0.050	0.600	0.642

G91R	Disease	Disease	Disease	Disease	Disease	3
	0.849	0.868	0.040	0.720	0.669

G92W	Disease	Disease	Disease	Disease	Disease	9
	0.999	0.931	0.000	0.780	0.944

D93G	Disease	Disease	Disease	Disease	Disease	7
	0.974	0.880	0.000	0.630	0.845

D93N	Disease	Disease	Disease	Disease	Disease	1
	0.737	0.755	0.030	0.545	0.571

L94V	Disease	Disease	Disease	Neutral	Disease	2
	0.850	0.599	0.040	0.500	0.618

S96G	Disease	Neutral	Neutral	Neutral	Neutral	1
	0.775	0.163	0.190	0.280	0.465

S96N	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.449	0.210	0.270	0.180	0.382

V97L	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.405	0.109	1.000	0.155	0.283

T99A	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.491	0.148	0.350	0.210	0.272

T99I	Disease	Neutral	Neutral	Neutral	Disease	1
	0.593	0.265	0.050	0.245	0.543

G101R	Disease	Neutral	Neutral	Neutral	Neutral	4
	0.509	0.394	0.360	0.405	0.319

T102S	NA	Neutral	Neutral	Neutral	Neutral	5
	-	0.113	0.220	0.185	0.251

E104D	NA	Neutral	Neutral	Neutral	Neutral	5
	-	0.157	0.470	0.210	0.235

E104K	NA	Neutral	Neutral	Neutral	Neutral	5
	-	0.119	0.590	0.270	0.228

R105S	Disease	Disease	Neutral	Neutral	Disease	1
	0.681	0.509	0.280	0.475	0.530

Q106R	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.479	0.224	0.890	0.220	0.376

L108S	Disease	Disease	Disease	Disease	Disease	7
	0.973	0.740	0.030	0.555	0.844

D109H	Disease	Neutral	Disease	Disease	Disease	3
	0.819	0.319	0.050	0.505	0.635

E111A	Disease	Neutral	Neutral	Neutral	Disease	2
	0.842	0.286	0.190	0.370	0.581

E111D	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.477	0.138	0.800	0.125	0.299

V113I	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.478	0.067	1.000	0.130	0.258

R115G	Disease	Neutral	Neutral	Neutral	Disease	1
	0.714	0.361	0.210	0.420	0.575

R115Q	Disease	Neutral	Neutral	Neutral	Disease	1
	0.719	0.243	0.290	0.235	0.539

V116G	Disease	Disease	Neutral	Neutral	Disease	2
	0.890	0.666	0.080	0.430	0.609

V116M	Disease	Neutral	Neutral	Neutral	Disease	2
	0.556	0.445	0.130	0.215	0.604

M117T	Neutral	Neutral	Disease	Neutral	Neutral	1
	0.422	0.410	0.040	0.490	0.466

M117V	Disease	Neutral	Disease	Disease	Disease	1
	0.534	0.453	0.010	0.555	0.552

T118I	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.497	0.191	0.680	0.175	0.271

Q119R	Disease	Disease	Disease	Disease	Disease	5
	0.991	0.808	0.000	0.745	0.731

T121S	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.402	0.234	0.240	0.175	0.455

L122M	Disease	Neutral	Neutral	Neutral	Neutral	0
	0.713	0.193	0.160	0.155	0.497

A123V	Disease	Disease	Disease	Disease	Disease	6
	0.984	0.681	0.000	0.610	0.812

E126K	Disease	Neutral	Neutral	Neutral	Disease	2
	0.569	0.414	0.220	0.435	0.604

E126Q	Disease	Neutral	Neutral	Neutral	Neutral	0
	0.675	0.220	0.210	0.375	0.494

E126V	Disease	Neutral	Neutral	Neutral	Disease	0
	0.538	0.350	0.380	0.430	0.502

C127Y	Disease	Disease	Disease	Disease	Disease	7
	0.966	0.706	0.000	0.640	0.834

R130G	NA	Disease	Neutral	Disease	Neutral	1
	-	0.518	0.360	0.515	0.448

R130Q	NA	Neutral	Neutral	Neutral	Neutral	7
	-	0.404	0.210	0.415	0.170

S131N	NA	Neutral	Neutral	Neutral	Neutral	6
	-	0.124	0.500	0.240	0.222

D132A	NA	Neutral	Neutral	Disease	Neutral	4
	-	0.372	0.090	0.585	0.301

D132E	NA	Neutral	Neutral	Neutral	Neutral	6
	-	0.261	0.150	0.440	0.185

D132N	NA	Neutral	Neutral	Neutral	Neutral	6
	-	0.190	0.320	0.475	0.177

G133C	NA	Disease	Disease	Disease	Disease	4
	-	0.520	0.010	0.605	0.702

G134D	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.496	0.328	0.230	0.480	0.343

G134S	Disease	Neutral	Neutral	Neutral	Neutral	5
	0.557	0.065	0.550	0.230	0.227

H135Q	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.409	0.223	0.580	0.245	0.406

H135Y	Disease	Neutral	Neutral	Neutral	Disease	2
	0.864	0.338	0.070	0.315	0.612

T136P	Disease	Neutral	Neutral	Neutral	Disease	2
	0.857	0.340	0.070	0.350	0.623

V137I	Disease	Neutral	Neutral	Neutral	Neutral	4
	0.546	0.031	1.000	0.185	0.325

L138S	Disease	Disease	Disease	Disease	Disease	6
	0.994	0.700	0.000	0.555	0.801

H139L	Disease	Disease	Disease	Disease	Disease	7
	1.000	0.883	0.000	0.730	0.863

H139R	Disease	Disease	Disease	Disease	Disease	7
	1.000	0.859	0.000	0.765	0.859

R140Q	Disease	Disease	Disease	Disease	Disease	3
	0.948	0.863	0.000	0.800	0.641

R140W	Disease	Disease	Disease	Disease	Disease	6
	0.997	0.875	0.000	0.810	0.805

D141N	Disease	Disease	Disease	Disease	Disease	3
	0.938	0.859	0.010	0.840	0.633

L142M	Disease	Disease	Disease	Neutral	Disease	5
	0.956	0.542	0.020	0.360	0.730

K143N	Disease	Disease	Disease	Disease	Disease	4
	0.984	0.811	0.000	0.740	0.689

P144L	Disease	Disease	Disease	Disease	Disease	5
	0.984	0.519	0.020	0.550	0.774

A145G	Disease	Neutral	Neutral	Neutral	Disease	3
	0.781	0.312	0.230	0.165	0.633

N146K	Disease	Disease	Disease	Disease	Disease	4
	0.992	0.907	0.000	0.795	0.705

N146S	Disease	Disease	Disease	Disease	Disease	2
	0.947	0.853	0.000	0.715	0.612

V147I	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.549	0.057	1.000	0.160	0.331

F148L	Disease	Neutral	Neutral	Neutral	Disease	3
	0.706	0.351	0.100	0.480	0.638

D150H	Disease	Disease	Disease	Disease	Disease	4
	0.873	0.614	0.050	0.560	0.690

D150V	Disease	Disease	Neutral	Disease	Disease	3
	0.824	0.719	0.050	0.520	0.631

G151D	Neutral	Disease	Neutral	Neutral	Neutral	2
	0.423	0.513	0.560	0.255	0.411

G151S	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.481	0.192	0.650	0.155	0.332

K152E	Disease	Neutral	Neutral	Neutral	Disease	2
	0.545	0.385	0.470	0.330	0.577

K152Q	Disease	Neutral	Neutral	Neutral	Disease	1
	0.689	0.273	0.230	0.295	0.559

Q153K	Disease	Disease	Neutral	Neutral	Neutral	2
	0.543	0.559	0.670	0.335	0.387

Q153P	Disease	Disease	Neutral	Neutral	Disease	2
	0.840	0.781	0.130	0.415	0.583

N154K	Disease	Disease	Neutral	Neutral	Neutral	1
	0.529	0.515	0.940	0.365	0.456

N154T	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.415	0.262	0.700	0.220	0.445

V155I	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.534	0.195	0.420	0.210	0.341

L157V	Disease	Disease	Neutral	Neutral	Neutral	4
	0.783	0.544	0.060	0.270	0.304

G158V	Disease	Disease	Disease	Disease	Disease	4
	0.987	0.904	0.000	0.660	0.694

D159E	Disease	Disease	Disease	Disease	Disease	3
	0.921	0.896	0.000	0.805	0.633

R164G	Disease	Disease	Disease	Disease	Disease	7
	0.982	0.718	0.000	0.660	0.826

R164S	Disease	Disease	Disease	Disease	Disease	6
	0.973	0.711	0.000	0.635	0.825

I165L	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.423	0.276	0.250	0.195	0.451

H168L	Disease	Disease	Neutral	Neutral	Disease	0
	0.746	0.554	0.200	0.390	0.524

D169G	Disease	Neutral	Neutral	Neutral	Disease	3
	0.858	0.474	0.220	0.425	0.644

D169N	Disease	Neutral	Neutral	Neutral	Disease	3
	0.706	0.390	0.260	0.235	0.627

T170K	Disease	Disease	Neutral	Neutral	Neutral	0
	0.619	0.516	0.280	0.410	0.500

T170M	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.393	0.222	0.240	0.225	0.403

T170R	Disease	Disease	Neutral	Neutral	Disease	0
	0.728	0.539	0.340	0.445	0.514

S171N	Disease	Neutral	Neutral	Neutral	Disease	2
	0.659	0.356	0.260	0.225	0.601

F172S	Disease	Disease	Disease	Disease	Disease	4
	0.851	0.587	0.030	0.620	0.706

A173G	Disease	Disease	Disease	Disease	Disease	6
	0.971	0.765	0.010	0.565	0.807

A173T	Disease	Disease	Disease	Neutral	Disease	3
	0.868	0.664	0.050	0.455	0.643

K174I	Disease	Disease	Disease	Disease	Disease	4
	0.902	0.575	0.020	0.610	0.716

T175I	Disease	Disease	Disease	Disease	Disease	7
	0.993	0.821	0.030	0.735	0.828

F176L	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.518	0.290	0.400	0.455	0.349

V177I	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.541	0.138	0.220	0.330	0.327

G178S	Disease	Disease	Disease	Disease	Disease	8
	1.000	0.804	0.000	0.790	0.897

G178V	Disease	Disease	Disease	Disease	Disease	8
	1.000	0.849	0.000	0.815	0.898

T179I	Disease	Disease	Disease	Disease	Disease	4
	0.926	0.795	0.000	0.740	0.676

P180A	Disease	Disease	Disease	Disease	Disease	3
	0.925	0.681	0.000	0.750	0.662

P180H	Disease	Disease	Disease	Disease	Disease	5
	0.992	0.852	0.000	0.815	0.766

P180L	Disease	Disease	Disease	Disease	Disease	1
	0.912	0.846	0.000	0.720	0.567

Y181C	Disease	Disease	Disease	Disease	Neutral	2
	0.788	0.860	0.040	0.540	0.422

Y181H	Disease	Disease	Disease	Disease	Neutral	1
	0.722	0.706	0.040	0.595	0.467

Y181S	Disease	Disease	Disease	Disease	Disease	0
	0.875	0.786	0.030	0.545	0.522

Y182C	Disease	Disease	Disease	Disease	Disease	7
	0.997	0.892	0.000	0.785	0.831

Y182H	Disease	Disease	Disease	Disease	Disease	5
	0.986	0.823	0.000	0.820	0.765

M183I	Disease	Disease	Neutral	Neutral	Neutral	5
	0.759	0.624	0.070	0.405	0.255

M183L	Disease	Neutral	Neutral	Neutral	Neutral	1
	0.604	0.480	0.270	0.355	0.459

M183T	Disease	Disease	Neutral	Neutral	Disease	1
	0.848	0.811	0.060	0.490	0.569

S184T	Disease	Disease	Disease	Disease	Disease	4
	0.967	0.696	0.000	0.530	0.696

P185S	Disease	Disease	Disease	Disease	Disease	6
	0.998	0.842	0.000	0.595	0.785

Q187E	Disease	Neutral	Disease	Neutral	Disease	2
	0.836	0.474	0.020	0.380	0.619

Q187H	Disease	Neutral	Disease	Neutral	Disease	3
	0.858	0.341	0.010	0.410	0.651

M188I	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.461	0.172	0.590	0.220	0.278

M188R	Disease	Disease	Neutral	Neutral	Disease	0
	0.837	0.570	0.060	0.485	0.512

N189S	Disease	Neutral	Neutral	Neutral	Neutral	5
	0.518	0.153	0.640	0.145	0.250

R190C	Disease	Disease	Disease	Disease	Disease	4
	0.666	0.628	0.020	0.565	0.688

R190H	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.474	0.247	0.520	0.165	0.420

M191R	Disease	Disease	Neutral	Neutral	Neutral	1
	0.660	0.525	0.520	0.385	0.474

M191V	Disease	Neutral	Neutral	Neutral	Disease	2
	0.544	0.380	0.290	0.435	0.585

S192F	Disease	Disease	Disease	Neutral	Disease	5
	0.945	0.560	0.010	0.465	0.758

Y193C	Disease	Disease	Disease	Disease	Disease	6
	0.998	0.832	0.000	0.830	0.819

N194D	Disease	Neutral	Neutral	Neutral	Neutral	4
	0.529	0.189	0.440	0.285	0.295

N194S	Disease	Neutral	Neutral	Neutral	Disease	2
	0.658	0.343	0.300	0.285	0.621

S197P	Disease	Disease	Disease	Disease	Disease	4
	0.989	0.901	0.000	0.620	0.709

D198G	Disease	Disease	Disease	Disease	Disease	5
	0.986	0.876	0.000	0.780	0.731

D198N	Disease	Disease	Disease	Disease	Disease	5
	0.978	0.850	0.000	0.785	0.729

I199F	Disease	Disease	Disease	Disease	Disease	4
	0.984	0.786	0.000	0.630	0.716

I199T	Disease	Disease	Disease	Disease	Disease	3
	0.910	0.763	0.010	0.625	0.657

I199V	Disease	Neutral	Neutral	Neutral	Neutral	4
	0.581	0.155	0.230	0.290	0.321

W200C	Disease	Disease	Disease	Disease	Disease	8
	0.999	0.895	0.000	0.815	0.877

S201A	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.398	0.163	0.380	0.395	0.275

L202S	Disease	Disease	Disease	Disease	Disease	5
	0.991	0.772	0.000	0.645	0.726

G203D	Disease	Disease	Disease	Disease	Disease	6
	0.995	0.890	0.000	0.845	0.817

G203S	Disease	Disease	Disease	Disease	Disease	4
	0.974	0.835	0.000	0.770	0.695

C204R	Disease	Disease	Disease	Disease	Disease	5
	0.984	0.930	0.000	0.775	0.760

L206Q	Disease	Disease	Disease	Disease	Disease	6
	0.994	0.648	0.000	0.580	0.799

Y207H	Disease	Disease	Disease	Disease	Disease	4
	0.985	0.764	0.030	0.700	0.722

E208D	Disease	Disease	Disease	Disease	Disease	4
	0.907	0.598	0.000	0.715	0.705

C210S	Disease	Disease	Disease	Disease	Disease	5
	0.938	0.610	0.030	0.570	0.745

A211E	Disease	Disease	Disease	Disease	Disease	5
	0.921	0.646	0.010	0.625	0.748

L212F	Disease	Disease	Disease	Neutral	Disease	3
	0.884	0.606	0.050	0.295	0.635

M213I	Disease	Neutral	Disease	Neutral	Disease	1
	0.714	0.252	0.030	0.320	0.556

M213T	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.511	0.229	0.360	0.125	0.332

P214L	Disease	Disease	Neutral	Disease	Disease	3
	0.859	0.560	0.120	0.515	0.628

P215A	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.429	0.249	0.270	0.465	0.401

F216L	Disease	Disease	Disease	Disease	Disease	6
	0.980	0.793	0.000	0.670	0.807

T217R	Disease	Neutral	Neutral	Neutral	Neutral	4
	0.506	0.389	0.060	0.135	0.297

A218G	Disease	Neutral	Neutral	Neutral	Disease	1
	0.568	0.246	0.260	0.260	0.553

S220N	Disease	Neutral	Neutral	Neutral	Neutral	0
	0.584	0.202	1.000	0.170	0.484

S220R	Disease	Disease	Neutral	Disease	Disease	6
	0.881	0.829	0.140	0.560	0.777

Q221R	Disease	Neutral	Neutral	Neutral	Disease	3
	0.753	0.466	0.340	0.435	0.637

K222R	Disease	Neutral	Neutral	Neutral	Neutral	2
	0.786	0.204	0.420	0.340	0.421

L224H	Disease	Disease	Disease	Disease	Disease	7
	0.994	0.839	0.000	0.680	0.863

L224V	Disease	Disease	Disease	Neutral	Disease	3
	0.878	0.596	0.020	0.410	0.644

A225S	Disease	Neutral	Neutral	Neutral	Disease	2
	0.571	0.349	0.320	0.260	0.586

A225T	Disease	Neutral	Neutral	Neutral	Disease	2
	0.729	0.295	0.330	0.260	0.610

A225V	Disease	Neutral	Neutral	Neutral	Neutral	2
	0.676	0.160	0.690	0.130	0.396

K227E	Disease	Disease	Disease	Disease	Disease	6
	0.971	0.738	0.030	0.640	0.816

I228M	Disease	Disease	Disease	Disease	Disease	6
	0.983	0.724	0.020	0.550	0.796

I228S	Disease	Disease	Disease	Disease	Disease	7
	0.991	0.900	0.000	0.710	0.839

R229K	Disease	Neutral	Neutral	Neutral	Neutral	5
	0.529	0.183	1.000	0.125	0.242

E230D	Disease	Neutral	Neutral	Neutral	Disease	2
	0.848	0.258	0.120	0.255	0.576

F233L	Disease	Neutral	Neutral	Neutral	Disease	2
	0.615	0.461	0.160	0.400	0.608

R234S	Disease	Neutral	Neutral	Neutral	Neutral	2
	0.524	0.331	0.510	0.265	0.380

R235L	Disease	Disease	Neutral	Neutral	Disease	3
	0.816	0.711	0.060	0.475	0.654

R235P	Disease	Neutral	Neutral	Neutral	Disease	3
	0.687	0.309	1.000	0.290	0.628

R235Q	Disease	Neutral	Neutral	Neutral	Disease	2
	0.621	0.381	0.130	0.320	0.610

I236V	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.424	0.210	0.270	0.345	0.383

P237L	Disease	Disease	Disease	Disease	Disease	4
	0.830	0.811	0.010	0.635	0.723

P237T	Disease	Disease	Disease	Disease	Disease	4
	0.851	0.726	0.000	0.675	0.723

Y238C	Disease	Neutral	Neutral	Neutral	Disease	0
	0.782	0.427	0.060	0.310	0.522

Y238H	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.597	0.180	0.140	0.180	0.333

R239C	Disease	Disease	Neutral	Neutral	Disease	4
	0.935	0.591	0.240	0.365	0.709

R239H	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.429	0.181	0.660	0.215	0.308

R239S	Disease	Neutral	Neutral	Neutral	Disease	2
	0.758	0.392	0.520	0.450	0.600

S241F	Disease	Disease	Disease	Disease	Disease	7
	0.996	0.833	0.000	0.740	0.867

D242A	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.422	0.319	0.500	0.255	0.450

E243K	Disease	Disease	Neutral	Neutral	Disease	1
	0.742	0.592	0.070	0.440	0.532

L244S	Disease	Disease	Disease	Disease	Disease	7
	0.996	0.762	0.000	0.510	0.852

I247V	Disease	Neutral	Neutral	Neutral	Neutral	0
	0.577	0.209	0.540	0.170	0.488

I248T	Disease	Disease	Disease	Disease	Disease	6
	0.959	0.752	0.000	0.530	0.824

T249M	Disease	Neutral	Neutral	Neutral	Neutral	0
	0.883	0.171	0.090	0.130	0.487

R250K	Disease	Neutral	Neutral	Neutral	Neutral	1
	0.576	0.199	0.790	0.160	0.466

R250M	Disease	Neutral	Neutral	Neutral	Disease	1
	0.629	0.295	0.150	0.290	0.571

M251L	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.457	0.334	0.310	0.360	0.453

L252F	Disease	Disease	Disease	Disease	Neutral	0
	0.692	0.551	0.030	0.510	0.496

N253I	Disease	Neutral	Neutral	Neutral	Disease	3
	0.890	0.429	0.130	0.200	0.647

K255Q	Disease	Neutral	Neutral	Neutral	Disease	2
	0.684	0.292	0.120	0.145	0.595

D256G	Disease	Disease	Disease	Neutral	Disease	1
	0.814	0.628	0.020	0.390	0.554

D256V	Disease	Disease	Disease	Neutral	Disease	3
	0.840	0.669	0.040	0.355	0.628

Y257C	Disease	Neutral	Neutral	Neutral	Disease	2
	0.923	0.449	0.060	0.305	0.613

H258R	Disease	Neutral	Neutral	Neutral	Neutral	1
	0.556	0.213	0.620	0.200	0.442

R259Q	Disease	Disease	Disease	Disease	Disease	9
	1.000	0.868	0.000	0.860	0.942

P260L	Disease	Disease	Disease	Disease	Disease	6
	0.952	0.716	0.010	0.555	0.783

P260S	Disease	Disease	Disease	Disease	Disease	5
	0.905	0.754	0.000	0.595	0.758

E263K	Disease	Neutral	Neutral	Neutral	Disease	1
	0.598	0.249	0.570	0.200	0.529

E264G	Disease	Neutral	Disease	Disease	Disease	4
	0.896	0.410	0.020	0.610	0.677

I265V	Disease	Neutral	Neutral	Neutral	Disease	0
	0.786	0.212	0.130	0.265	0.515

L266V	Disease	Disease	Disease	Neutral	Disease	6
	0.961	0.609	0.010	0.490	0.797

E267K	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.384	0.165	0.460	0.160	0.312

N268K	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.431	0.239	0.340	0.460	0.443

P269R	Disease	Disease	Neutral	Disease	Disease	4
	0.907	0.748	0.080	0.605	0.724

P269S	Disease	Disease	Neutral	Neutral	Disease	3
	0.870	0.666	0.120	0.380	0.650

I271V	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.460	0.148	0.370	0.205	0.304

D273G	Disease	Neutral	Neutral	Neutral	Neutral	7
	0.502	0.371	0.420	0.410	0.139

D273N	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.338	0.203	0.500	0.180	0.359

V275A	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.507	0.354	0.760	0.240	0.348

V275I	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.387	0.115	0.220	0.130	0.314

A276V	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.738	0.179	0.290	0.365	0.340

D277E	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.456	0.197	1.000	0.130	0.324

E278K	Disease	Neutral	Neutral	Neutral	Neutral	0
	0.798	0.340	0.540	0.255	0.485

Q279K	Neutral	Neutral	Neutral	Neutral	Neutral	1
	0.316	0.388	0.410	0.325	0.432

R280K	Neutral	Neutral	Neutral	Neutral	Neutral	6
	0.369	0.147	0.310	0.285	0.186

R281G	Disease	Neutral	Neutral	Disease	Neutral	1
	0.754	0.338	0.120	0.535	0.475

R281I	Disease	Neutral	Neutral	Neutral	Neutral	2
	0.541	0.275	0.100	0.290	0.376

N282S	Disease	Neutral	Neutral	Neutral	Neutral	6
	0.585	0.071	0.710	0.190	0.194

L283H	Disease	Neutral	Neutral	Neutral	Disease	2
	0.593	0.468	0.400	0.325	0.609

G287R	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.379	0.209	0.560	0.400	0.295

R288Q	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.486	0.214	0.260	0.280	0.283

Q289H	Disease	Neutral	Neutral	Neutral	Neutral	7
	0.646	0.083	0.060	0.245	0.138

Q289P	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.370	0.371	0.140	0.400	0.409

G291R	Disease	Neutral	Neutral	Neutral	Neutral	6
	0.582	0.167	0.560	0.300	0.181

E292D	Disease	Neutral	Neutral	Neutral	Neutral	7
	0.714	0.073	0.480	0.370	0.144

E292K	Neutral	Neutral	Neutral	Neutral	Neutral	6
	0.412	0.152	0.610	0.485	0.182

P293R	Disease	Neutral	Neutral	Neutral	Neutral	6
	0.609	0.141	0.550	0.370	0.178

P293T	Disease	Neutral	Neutral	Neutral	Neutral	6
	0.703	0.106	0.570	0.200	0.176

K295I	Neutral	Neutral	Neutral	Disease	Neutral	5
	0.307	0.200	0.200	0.550	0.274

S296L	Neutral	Neutral	Neutral	Neutral	Neutral	7
	0.411	0.111	0.350	0.400	0.163

S296P	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.433	0.229	0.330	0.185	0.362

Q297E	Neutral	Neutral	Neutral	Neutral	Neutral	8
	0.450	0.060	0.870	0.205	0.117

D298Y	Disease	Neutral	Disease	Disease	Neutral	5
	0.762	0.171	0.040	0.595	0.262

S299F	Disease	Neutral	Neutral	Neutral	Neutral	4
	0.866	0.175	0.050	0.480	0.286

S300G	Disease	Neutral	Neutral	Neutral	Neutral	7
	0.628	0.077	0.380	0.335	0.128

S300N	Disease	Neutral	Neutral	Neutral	Neutral	6
	0.574	0.132	0.520	0.180	0.199

P301S	Neutral	Neutral	Neutral	Neutral	Neutral	6
	0.407	0.132	0.450	0.215	0.176

V302I	Neutral	Neutral	Neutral	Neutral	Neutral	8
	0.496	0.033	0.190	0.275	0.098

L303F	Disease	Neutral	Neutral	Neutral	Neutral	7
	0.797	0.116	0.710	0.300	0.175

L303V	Neutral	Neutral	Neutral	Neutral	Neutral	8
	0.446	0.070	0.570	0.285	0.109

S304I	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.381	0.268	0.190	0.405	0.365

S304R	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.430	0.254	0.520	0.490	0.344

K307N	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.481	0.197	0.120	0.465	0.253

L308V	Disease	Neutral	Neutral	Neutral	Neutral	7
	0.649	0.111	0.510	0.330	0.141

K309N	Disease	Neutral	Neutral	Disease	Neutral	4
	0.585	0.209	0.070	0.540	0.310

E310D	Disease	Neutral	Neutral	Neutral	Neutral	2
	0.580	0.310	0.090	0.300	0.415

E310G	Disease	Neutral	Neutral	Disease	Neutral	1
	0.636	0.317	0.060	0.610	0.427

E310K	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.387	0.290	0.200	0.415	0.356

I311N	Neutral	Neutral	Neutral	Neutral	Neutral	2
	0.440	0.415	0.420	0.420	0.392

I311V	Neutral	Neutral	Neutral	Neutral	Neutral	8
	0.302	0.052	0.230	0.375	0.115

Q312R	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.602	0.261	0.560	0.415	0.368

L313I	Disease	Neutral	Neutral	Neutral	Neutral	1
	0.710	0.324	0.110	0.230	0.443

Q314E	Disease	Neutral	Neutral	Neutral	Neutral	3
	0.617	0.286	1.000	0.220	0.368

R316Q	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.337	0.393	0.180	0.380	0.329

E317K	Neutral	Neutral	Neutral	Disease	Neutral	1
	0.229	0.494	0.120	0.570	0.454

R318Q	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.247	0.239	0.880	0.175	0.274

A319T	Disease	Neutral	Neutral	Neutral	Neutral	7
	0.549	0.095	0.100	0.405	0.133

K321Q	Neutral	Neutral	Neutral	Neutral	Neutral	7
	0.475	0.164	0.150	0.465	0.168

A322E	Neutral	Neutral	Neutral	Neutral	Neutral	7
	0.247	0.134	1.000	0.230	0.151

E324K	Disease	Neutral	Neutral	Neutral	Neutral	2
	0.768	0.306	0.120	0.460	0.381

E325K	Neutral	Neutral	Neutral	Disease	Neutral	4
	0.204	0.339	0.670	0.520	0.283

R326S	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.324	0.294	0.370	0.405	0.305

E328A	Disease	Neutral	Neutral	Neutral	Neutral	5
	0.629	0.206	0.330	0.355	0.275

E328D	Disease	Neutral	Neutral	Neutral	Neutral	7
	0.686	0.176	0.090	0.395	0.175

Q329H	Disease	Neutral	Disease	Disease	Disease	0
	0.742	0.331	0.030	0.585	0.511

Q329K	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.492	0.308	0.260	0.325	0.276

Q329P	Disease	Disease	Neutral	Disease	Disease	4
	0.774	0.689	0.070	0.655	0.695

E331V	Disease	Neutral	Disease	Disease	Neutral	2
	0.746	0.314	0.010	0.695	0.398

Q332L	Neutral	Neutral	Neutral	Disease	Neutral	4
	0.330	0.257	0.150	0.505	0.297

V336G	Disease	Neutral	Disease	Disease	Disease	1
	0.749	0.464	0.020	0.595	0.572

R337C	Disease	Disease	Disease	Disease	Disease	5
	0.888	0.723	0.000	0.675	0.736

R337H	Neutral	Disease	Disease	Disease	Disease	3
	0.329	0.625	0.010	0.600	0.663

R337P	Neutral	Disease	Neutral	Disease	Disease	4
	0.460	0.849	0.070	0.635	0.711

E338G	Disease	Disease	Disease	Disease	Disease	3
	0.742	0.524	0.020	0.660	0.665

E338K	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.280	0.476	0.160	0.365	0.365

D343G	Disease	Disease	Neutral	Disease	Neutral	0
	0.583	0.606	0.130	0.520	0.489

D343N	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.214	0.444	0.240	0.290	0.338

L345V	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.344	0.378	0.160	0.390	0.311

A346V	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.424	0.283	0.310	0.355	0.306

R347G	Neutral	Disease	Neutral	Disease	Disease	4
	0.375	0.679	0.160	0.575	0.714

R347K	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.363	0.389	0.150	0.395	0.305

R347T	Neutral	Disease	Neutral	Disease	Neutral	0
	0.478	0.601	0.220	0.540	0.482

A348S	Neutral	Disease	Neutral	Neutral	Disease	0
	0.414	0.724	0.120	0.420	0.506

A348V	Neutral	Disease	Neutral	Neutral	Neutral	2
	0.338	0.603	0.110	0.485	0.416

N350K	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.275	0.388	0.600	0.215	0.294

L351V	Neutral	Neutral	Neutral	Neutral	Neutral	3
	0.403	0.367	0.100	0.300	0.344

L352F	Disease	Neutral	Neutral	Neutral	Disease	1
	0.566	0.388	0.120	0.400	0.572

N354S	Neutral	Neutral	Neutral	Neutral	Neutral	4
	0.210	0.385	0.960	0.430	0.294

Y355C	Disease	Disease	Disease	Disease	Neutral	0
	0.576	0.701	0.020	0.685	0.489

S356N	Neutral	Neutral	Neutral	Neutral	Neutral	8
	0.230	0.176	1.000	0.145	0.114

K359R	Neutral	Neutral	Neutral	Neutral	Neutral	5
	0.410	0.251	0.540	0.270	0.258

E360K	Neutral	Disease	Neutral	Disease	Disease	4
	0.345	0.796	0.280	0.585	0.685

R361L	Neutral	Disease	Neutral	Disease	Disease	4
	0.194	0.553	0.050	0.635	0.685

R361W	Disease	Disease	Disease	Disease	Disease	4
	0.807	0.554	0.010	0.705	0.707

K362T	Neutral	Disease	Disease	Disease	Disease	4
	0.442	0.536	0.020	0.580	0.675

F363Y	Neutral	Neutral	Neutral	Neutral	Neutral	8
	0.262	0.109	0.090	0.495	0.076

S365F	Neutral	Disease	Neutral	Disease	Disease	3
	0.380	0.569	0.070	0.545	0.644

S365T	Neutral	Neutral	Neutral	Neutral	Neutral	9
	0.148	0.187	0.340	0.435	0.064

L366V	Neutral	Neutral	Neutral	Neutral	Neutral	8
	0.157	0.265	0.230	0.430	0.112

S368N	NA	Neutral	Neutral	Neutral	Neutral	9
	-	0.196	0.580	0.470	0.070

N369K	NA	Neutral	Neutral	Disease	Neutral	7
	-	0.321	0.370	0.525	0.140

P370T	NA	Neutral	Neutral	Neutral	Neutral	7
	-	0.286	0.650	0.395	0.128

L372R	NA	Disease	Neutral	Disease	Disease	1
	-	0.575	0.070	0.525	0.564

L373F	NA	Neutral	Neutral	Neutral	Neutral	8
	-	0.258	0.190	0.430	0.103

L373R	NA	Neutral	Neutral	Disease	Neutral	7
	-	0.422	0.110	0.540	0.141

L375F	NA	Neutral	Disease	Disease	Neutral	8
	-	0.278	0.040	0.565	0.092

P376L	NA	Neutral	Disease	Disease	Neutral	3
	-	0.476	0.040	0.590	0.372

P376S	NA	Neutral	Neutral	Neutral	Neutral	9
	-	0.267	0.470	0.460	0.071

S377F	NA	Disease	Neutral	Neutral	Neutral	3
	-	0.510	0.850	0.325	0.358

V379A	NA	Neutral	Neutral	Neutral	Neutral	9
	-	0.089	0.270	0.480	0.032

V379L	NA	Neutral	Neutral	Neutral	Neutral	9
	-	0.119	0.080	0.430	0.059

I380F	NA	Neutral	Disease	Disease	Neutral	7
	-	0.331	0.020	0.595	0.164

K381E	NA	Disease	Disease	Disease	Disease	2
	-	0.650	0.050	0.675	0.610

K381N	NA	Disease	Disease	Disease	Disease	2
	-	0.534	0.030	0.640	0.588

K382N	NA	Disease	Disease	Disease	Disease	2
	-	0.508	0.000	0.670	0.582

K383Q	NA	Neutral	Disease	Disease	Neutral	7
	-	0.320	0.030	0.620	0.135

H385L	NA	Disease	Disease	Disease	Neutral	2
	-	0.632	0.000	0.700	0.390

F386L	NA	Disease	Disease	Disease	Neutral	3
	-	0.510	0.000	0.615	0.354

S387G	NA	Neutral	Neutral	Neutral	Neutral	9
	-	0.105	0.910	0.220	0.058

S387I	NA	Disease	Disease	Disease	Disease	3
	-	0.555	0.020	0.585	0.648

S387N	NA	Neutral	Disease	Disease	Neutral	6
	-	0.362	0.040	0.575	0.179

S390G	NA	Neutral	Neutral	Neutral	Neutral	8
	-	0.255	0.710	0.300	0.094

S390N	NA	Neutral	Neutral	Disease	Disease	1
	-	0.495	0.110	0.555	0.557

S390T	NA	Neutral	Neutral	Disease	Neutral	6
	-	0.431	0.170	0.525	0.212

N393S	NA	Disease	Disease	Disease	Disease	2
	-	0.620	0.040	0.595	0.614

I394V	NA	Neutral	Neutral	Neutral	Neutral	9
	-	0.058	0.070	0.450	0.029

M395I	NA	Neutral	Neutral	Disease	Neutral	0
	-	0.493	0.080	0.510	0.478

M395T	NA	Neutral	Neutral	Disease	Neutral	8
	-	0.437	0.310	0.520	0.120

M395V	NA	Neutral	Neutral	Disease	Neutral	8
	-	0.306	0.130	0.550	0.104

R396S	NA	Neutral	Neutral	Disease	Neutral	8
	-	0.407	0.380	0.565	0.098

S397C	NA	Neutral	Neutral	Disease	Neutral	7
	-	0.434	0.090	0.510	0.169

S397N	NA	Neutral	Neutral	Disease	Neutral	7
	-	0.354	0.160	0.525	0.147

E398K	NA	Neutral	Neutral	Disease	Neutral	9
	-	0.267	0.060	0.545	0.072

N399K	NA	Neutral	Neutral	Neutral	Neutral	6
	-	0.422	0.500	0.410	0.178

S400C	NA	Neutral	Disease	Disease	Neutral	7
	-	0.378	0.050	0.595	0.155

E401Q	NA	Neutral	Neutral	Neutral	Neutral	7
	-	0.338	0.350	0.315	0.129

S402C	NA	Neutral	Disease	Disease	Neutral	6
	-	0.399	0.010	0.510	0.193

S402R	NA	Neutral	Disease	Disease	Neutral	7
	-	0.412	0.030	0.595	0.166

Q403R	NA	Neutral	Neutral	Disease	Neutral	9
	-	0.084	0.270	0.525	0.034

L404V	NA	Neutral	Neutral	Neutral	Neutral	8
	-	0.201	0.250	0.455	0.118

T405I	NA	Neutral	Neutral	Disease	Neutral	9
	-	0.047	0.270	0.515	0.037

T405S	NA	Neutral	Neutral	Neutral	Neutral	9
	-	0.062	0.360	0.470	0.032

S406C	NA	Neutral	Disease	Disease	Neutral	7
	-	0.265	0.010	0.615	0.131

S406P	NA	Neutral	Disease	Disease	Neutral	5
	-	0.460	0.020	0.600	0.269

S408Y	NA	Neutral	Disease	Disease	Neutral	6
	-	0.401	0.000	0.615	0.190

K409R	NA	Neutral	Disease	Disease	Neutral	7
	-	0.179	0.030	0.580	0.129

C410Y	NA	Disease	Neutral	Disease	Disease	3
	-	0.800	0.100	0.740	0.666

K411Q	NA	Neutral	Disease	Disease	Neutral	8
	-	0.183	0.020	0.590	0.111

K411R	NA	Neutral	Disease	Disease	Neutral	8
	-	0.077	0.020	0.565	0.097

D412G	NA	Disease	Neutral	Disease	Disease	2
	-	0.643	0.120	0.680	0.618

D412N	NA	Neutral	Neutral	Disease	Neutral	7
	-	0.413	0.070	0.605	0.127

R416S	NA	Disease	Disease	Disease	Disease	3
	-	0.719	0.000	0.715	0.637

L417P	NA	Disease	Disease	Disease	Disease	3
	-	0.767	0.020	0.610	0.635

A419G	NA	Disease	Neutral	Neutral	Neutral	0
	-	0.649	0.400	0.465	0.491

A419T	NA	Disease	Neutral	Neutral	Neutral	1
	-	0.571	0.230	0.490	0.462

L422M	NA	Neutral	Neutral	Neutral	Neutral	8
	-	0.343	0.110	0.495	0.124

L422P	NA	Disease	Disease	Disease	Disease	3
	-	0.817	0.020	0.600	0.653

R423Q	NA	Disease	Disease	Disease	Disease	3
	-	0.764	0.000	0.705	0.662

R423W	NA	Disease	Disease	Disease	Disease	4
	-	0.833	0.000	0.765	0.702

A424P	NA	Disease	Neutral	Neutral	Disease	4
	-	0.860	0.070	0.465	0.675

A426T	NA	Neutral	Neutral	Neutral	Neutral	7
	-	0.451	0.280	0.340	0.141

A426V	NA	Disease	Disease	Disease	Disease	2
	-	0.750	0.010	0.660	0.610

L427P	NA	Disease	Disease	Disease	Disease	3
	-	0.817	0.000	0.675	0.661

L427V	NA	Disease	Disease	Disease	Disease	1
	-	0.561	0.000	0.530	0.537

S428P	NA	Disease	Neutral	Neutral	Disease	4
	-	0.833	0.260	0.360	0.713

S428T	NA	Neutral	Neutral	Neutral	Neutral	6
	-	0.445	0.230	0.355	0.200

D429N	NA	Disease	Disease	Disease	Disease	3
	-	0.624	0.010	0.625	0.663

I430T	NA	Neutral	Neutral	Disease	Neutral	4
	-	0.470	0.070	0.535	0.319

I430V	NA	Neutral	Neutral	Neutral	Neutral	8
	-	0.158	1.000	0.205	0.084

E431K	NA	Disease	Disease	Disease	Disease	3
	-	0.810	0.000	0.640	0.653

K432E	NA	Disease	Disease	Disease	Disease	2
	-	0.697	0.040	0.645	0.612

K432N	NA	Disease	Disease	Disease	Disease	2
	-	0.640	0.030	0.625	0.618

N433H	NA	Disease	Disease	Disease	Disease	2
	-	0.656	0.020	0.685	0.614

N433S	NA	Disease	Neutral	Disease	Disease	2
	-	0.652	0.070	0.585	0.613

Y434D	NA	Disease	Disease	Disease	Disease	4
	-	0.858	0.020	0.685	0.688

Q435H	NA	Disease	Neutral	Neutral	Neutral	0
	-	0.726	0.420	0.355	0.496

Q435R	NA	Disease	Neutral	Disease	Disease	3
	-	0.812	0.160	0.580	0.649

L436M	NA	Disease	Neutral	Neutral	Neutral	1
	-	0.648	0.160	0.470	0.465

L436P	NA	Disease	Neutral	Neutral	Neutral	1
	-	0.751	0.130	0.305	0.470

K437E	NA	Disease	Disease	Disease	Disease	3
	-	0.758	0.000	0.670	0.651

K437N	NA	Disease	Disease	Disease	Disease	3
	-	0.718	0.000	0.675	0.653

R439G	NA	Disease	Disease	Disease	Disease	2
	-	0.670	0.000	0.685	0.613

R439S	NA	Disease	Disease	Disease	Disease	2
	-	0.730	0.000	0.655	0.617

Q440H	NA	Neutral	Disease	Disease	Neutral	1
	-	0.485	0.000	0.695	0.444

Q440K	NA	Disease	Disease	Disease	Disease	2
	-	0.640	0.000	0.595	0.615

I441N	NA	Disease	Disease	Disease	Disease	2
	-	0.670	0.000	0.640	0.615

L442Q	NA	Neutral	Neutral	Neutral	Neutral	7
	-	0.415	0.240	0.325	0.147

M444I	NA	Neutral	Neutral	Neutral	Neutral	9
	-	0.151	0.290	0.265	0.075

M444V	NA	Neutral	Disease	Disease	Neutral	6
	-	0.225	0.010	0.505	0.204

R445C	NA	Neutral	Disease	Disease	Neutral	4
	-	0.307	0.000	0.730	0.305

R445H	NA	Neutral	Disease	Disease	Neutral	5
	-	0.277	0.000	0.690	0.267

Mutation: WT+POS+NEW
    WT: Residue in wild-type protein
    POS: Residue position
    NEW: New residue after mutation

Prediction:
    Neutral: Neutral variants
    Disease: Disease causing variants

Outputs: Value reported under each prediction
     PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    PhD-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    SIFT: Positive Value (If >0.05 mutation is predicted Neutral)
    SNAP: Output normalized between 0 and 1 (If >0.5 mutation is predicted Disease)
    Meta-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)

RI: Reliability Index between 0 and 10.