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Meta-SNP
Meta-predictor of disease causing variants


Sequence File: fileseq.seq
Alignment File: fileseq.seq.blast
Output File: output.txt





Mutation
PANTHER
PhD-SNP
SIFT
SNAP
Meta-SNP
RI

Neutral
Neutral
Neutral
Disease
Neutral
1
 
0.240
0.323
0.250
0.546
0.446
 
Neutral
Disease
Disease
Disease
Disease
3
 
0.296
0.852
0.000
0.793
0.658
 
Disease
Disease
Disease
Disease
Disease
6
 
0.510
0.658
0.000
0.874
0.794
 
NA
Neutral
Neutral
Neutral
Neutral
9
 
-
0.119
0.610
0.138
0.072
 



Mutation: WT+POS+NEW
    WT: Residue in wild-type protein
    POS: Residue position
    NEW: New residue after mutation

Prediction:
    Neutral: Neutral variants
    Disease: Disease causing variants

Outputs: Value reported under each prediction
     PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    PhD-SNP: Between 0 and 1.(If >0.5 mutation is predicted Disease)
    SIFT: Positive Value (If >0.05 mutation is predicted Neutral)
    SNAP: Output normalized between 0 and 1 (If >0.5 mutation is predicted Disease)
    Meta-SNP:Between 0 and 1. (If >0.5 mutation is predicted Disease)

RI: Reliability Index between 0 and 10.