Meta-SNP

Meta-SNP
Meta-predictor of disease causing variants

Sequence File: fileseq.seq
Alignment File: fileseq.seq.blast
Output File: output.txt


Mutation	PANTHER	PhD-SNP	SIFT	SNAP	Meta-SNP	RI

D107H	Neutral	Neutral	Neutral	Disease	Neutral	1
	0.240	0.323	0.250	0.540	0.446

I387T	Neutral	Disease	Disease	Disease	Disease	3
	0.296	0.852	0.000	0.755	0.658

C613R	Disease	Disease	Disease	Disease	Disease	6
	0.510	0.658	0.000	0.825	0.794

K858R	NA	Neutral	Neutral	Neutral	Neutral	9
	-	0.119	0.610	0.185	0.072

Mutation: WT+POS+NEW
    WT: Residue in wild-type protein
    POS: Residue position
    NEW: New residue after mutation

Prediction:
    Neutral: Neutral variants
    Disease: Disease causing variants

Outputs: Value reported under each prediction
     PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    PhD-SNP: Between 0 and 1.(If >0.5 mutation is predicted Disease)
    SIFT: Positive Value (If >0.05 mutation is predicted Neutral)
    SNAP: Output normalized between 0 and 1 (If >0.5 mutation is predicted Disease)
    Meta-SNP:Between 0 and 1. (If >0.5 mutation is predicted Disease)

RI: Reliability Index between 0 and 10.