********************************************************************************************** ** ** ** SNPs&GO ** ** Predicting disease associated variation using GO terms ** ** ** ********************************************************************************************** Sequence File: fileseq.seq Mutation Prediction RI Probability Method I586V Neutral 5 0.261 PhD-SNP: F[I]=64% F[V]=0% Nali=24 I586V Neutral 7 0.141 PANTHER: F[I]=49% F[V]=14% I586V Neutral 9 0.050 SNPs&GO A587S Neutral 1 0.450 PhD-SNP: F[A]=68% F[S]=8% Nali=24 A587S Neutral 4 0.280 PANTHER: F[A]=55% F[S]=6% A587S Neutral 4 0.283 SNPs&GO A587T Neutral 1 0.463 PhD-SNP: F[A]=68% F[T]=4% Nali=24 A587T Neutral 3 0.338 PANTHER: F[A]=55% F[T]=4% A587T Neutral 4 0.312 SNPs&GO L589M Neutral 7 0.167 PhD-SNP: F[L]=56% F[M]=8% Nali=24 L589M Neutral 5 0.233 PANTHER: F[L]=15% F[M]=2% L589M Neutral 9 0.027 SNPs&GO S591C Neutral 3 0.343 PhD-SNP: F[S]=52% F[C]=0% Nali=24 S591C Disease 2 0.623 PANTHER: F[S]=53% F[C]=1% S591C Neutral 4 0.311 SNPs&GO S591P Neutral 3 0.357 PhD-SNP: F[S]=52% F[P]=8% Nali=24 S591P Disease 0 0.515 PANTHER: F[S]=53% F[P]=1% S591P Neutral 2 0.411 SNPs&GO S592G Neutral 9 0.066 PhD-SNP: F[S]=56% F[G]=16% Nali=24 S592G Neutral 3 0.347 PANTHER: F[S]=53% F[G]=4% S592G Neutral 9 0.065 SNPs&GO S592N Neutral 8 0.120 PhD-SNP: F[S]=56% F[N]=12% Nali=24 S592N Neutral 1 0.434 PANTHER: F[S]=53% F[N]=2% S592N Neutral 7 0.169 SNPs&GO T593I Neutral 6 0.189 PhD-SNP: F[T]=26% F[I]=0% Nali=22 T593I Neutral 5 0.234 PANTHER: F[T]=16% F[I]=2% T593I Neutral 9 0.043 SNPs&GO T593P Neutral 9 0.039 PhD-SNP: F[T]=26% F[P]=43% Nali=22 T593P Neutral 8 0.081 PANTHER: F[T]=16% F[P]=28% T593P Neutral 10 0.006 SNPs&GO A595D Disease 1 0.551 PhD-SNP: F[A]=55% F[D]=0% Nali=21 A595D Neutral 3 0.337 PANTHER: F[A]=16% F[D]=1% A595D Neutral 6 0.213 SNPs&GO A595T Neutral 7 0.168 PhD-SNP: F[A]=55% F[T]=9% Nali=21 A595T Neutral 7 0.150 PANTHER: F[A]=16% F[T]=4% A595T Neutral 9 0.060 SNPs&GO R596K Neutral 5 0.264 PhD-SNP: F[R]=77% F[K]=0% Nali=21 R596K Neutral 5 0.239 PANTHER: F[R]=58% F[K]=8% R596K Neutral 7 0.137 SNPs&GO R596S Disease 0 0.505 PhD-SNP: F[R]=77% F[S]=0% Nali=21 R596S Neutral 1 0.452 PANTHER: F[R]=58% F[S]=2% R596S Neutral 2 0.407 SNPs&GO P597T Neutral 4 0.311 PhD-SNP: F[P]=89% F[T]=0% Nali=18 P597T Disease 1 0.541 PANTHER: F[P]=70% F[T]=2% P597T Neutral 3 0.349 SNPs&GO S598T Neutral 7 0.165 PhD-SNP: F[S]=77% F[T]=0% Nali=21 S598T Neutral 4 0.322 PANTHER: F[S]=53% F[T]=4% S598T Neutral 8 0.111 SNPs&GO P599S Neutral 3 0.367 PhD-SNP: F[P]=96% F[S]=0% Nali=22 P599S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P599S Neutral 3 0.351 SNPs&GO Q600E Neutral 7 0.138 PhD-SNP: F[Q]=48% F[E]=0% Nali=24 Q600E Neutral 7 0.132 PANTHER: F[Q]=20% F[E]=6% Q600E Neutral 9 0.044 SNPs&GO Q600H Neutral 7 0.172 PhD-SNP: F[Q]=48% F[H]=0% Nali=24 Q600H Neutral 5 0.272 PANTHER: F[Q]=20% F[H]=2% Q600H Neutral 9 0.051 SNPs&GO Q600R Neutral 9 0.074 PhD-SNP: F[Q]=48% F[R]=12% Nali=24 Q600R Neutral 8 0.099 PANTHER: F[Q]=20% F[R]=9% Q600R Neutral 10 0.021 SNPs&GO V601A Neutral 9 0.034 PhD-SNP: F[V]=28% F[A]=20% Nali=24 V601A Neutral 8 0.119 PANTHER: F[V]=19% F[A]=7% V601A Neutral 10 0.020 SNPs&GO V601I Neutral 9 0.050 PhD-SNP: F[V]=28% F[I]=0% Nali=24 V601I Neutral 8 0.109 PANTHER: F[V]=19% F[I]=7% V601I Neutral 10 0.014 SNPs&GO P602L Neutral 5 0.273 PhD-SNP: F[P]=76% F[L]=0% Nali=24 P602L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P602L Neutral 3 0.374 SNPs&GO P602T Neutral 6 0.190 PhD-SNP: F[P]=76% F[T]=8% Nali=24 P602T Disease 1 0.541 PANTHER: F[P]=70% F[T]=2% P602T Neutral 4 0.276 SNPs&GO R605W Disease 1 0.573 PhD-SNP: F[R]=84% F[W]=0% Nali=24 R605W Disease 7 0.841 PANTHER: F[R]=58% F[W]=0% R605W Disease 1 0.558 SNPs&GO R606C Disease 1 0.528 PhD-SNP: F[R]=80% F[C]=0% Nali=24 R606C Disease 6 0.789 PANTHER: F[R]=58% F[C]=0% R606C Disease 1 0.539 SNPs&GO R606H Neutral 0 0.493 PhD-SNP: F[R]=80% F[H]=0% Nali=24 R606H Disease 2 0.586 PANTHER: F[R]=58% F[H]=1% R606H Neutral 1 0.439 SNPs&GO R606L Neutral 0 0.492 PhD-SNP: F[R]=80% F[L]=4% Nali=24 R606L Neutral 0 0.493 PANTHER: F[R]=58% F[L]=2% R606L Neutral 0 0.477 SNPs&GO R606S Disease 0 0.523 PhD-SNP: F[R]=80% F[S]=0% Nali=24 R606S Neutral 1 0.452 PANTHER: F[R]=58% F[S]=2% R606S Neutral 2 0.413 SNPs&GO P608L Neutral 5 0.251 PhD-SNP: F[P]=64% F[L]=0% Nali=24 P608L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P608L Neutral 3 0.374 SNPs&GO P609A Neutral 6 0.224 PhD-SNP: F[P]=72% F[A]=0% Nali=24 P609A Neutral 8 0.114 PANTHER: F[P]=22% F[A]=8% P609A Neutral 9 0.043 SNPs&GO Q610K Neutral 6 0.204 PhD-SNP: F[Q]=65% F[K]=13% Nali=22 Q610K Neutral 8 0.102 PANTHER: F[Q]=14% F[K]=31% Q610K Neutral 10 0.017 SNPs&GO A612T Neutral 6 0.203 PhD-SNP: F[A]=73% F[T]=5% Nali=21 A612T Neutral 8 0.117 PANTHER: F[A]=38% F[T]=14% A612T Neutral 9 0.044 SNPs&GO L614F Neutral 5 0.254 PhD-SNP: F[L]=75% F[F]=0% Nali=19 L614F Neutral 5 0.232 PANTHER: F[L]=18% F[F]=2% L614F Neutral 9 0.044 SNPs&GO L614I Neutral 7 0.131 PhD-SNP: F[L]=75% F[I]=5% Nali=19 L614I Neutral 8 0.112 PANTHER: F[L]=18% F[I]=7% L614I Neutral 10 0.017 SNPs&GO L614V Neutral 7 0.173 PhD-SNP: F[L]=75% F[V]=0% Nali=19 L614V Neutral 8 0.100 PANTHER: F[L]=18% F[V]=8% L614V Neutral 10 0.017 SNPs&GO S615Y Neutral 4 0.315 PhD-SNP: F[S]=86% F[Y]=0% Nali=20 S615Y Disease 3 0.649 PANTHER: F[S]=53% F[Y]=1% S615Y Neutral 5 0.242 SNPs&GO S616C Neutral 5 0.271 PhD-SNP: F[S]=76% F[C]=0% Nali=20 S616C Disease 2 0.623 PANTHER: F[S]=53% F[C]=1% S616C Neutral 7 0.161 SNPs&GO S616G Neutral 7 0.159 PhD-SNP: F[S]=76% F[G]=0% Nali=20 S616G Neutral 3 0.347 PANTHER: F[S]=53% F[G]=4% S616G Neutral 9 0.060 SNPs&GO S616I Neutral 3 0.343 PhD-SNP: F[S]=76% F[I]=0% Nali=20 S616I Disease 1 0.542 PANTHER: F[S]=53% F[I]=1% S616I Neutral 6 0.197 SNPs&GO S616R Neutral 6 0.218 PhD-SNP: F[S]=76% F[R]=5% Nali=20 S616R Neutral 0 0.483 PANTHER: F[S]=53% F[R]=2% S616R Neutral 7 0.160 SNPs&GO P617A Neutral 8 0.091 PhD-SNP: F[P]=86% F[A]=5% Nali=20 P617A Neutral 1 0.435 PANTHER: F[P]=70% F[A]=3% P617A Neutral 8 0.114 SNPs&GO P617S Neutral 5 0.260 PhD-SNP: F[P]=86% F[S]=0% Nali=20 P617S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P617S Neutral 4 0.279 SNPs&GO C618R Neutral 2 0.400 PhD-SNP: F[C]=33% F[R]=0% Nali=20 C618R Neutral 6 0.223 PANTHER: F[C]=13% F[R]=2% C618R Neutral 7 0.126 SNPs&GO S619F Neutral 7 0.140 PhD-SNP: F[S]=29% F[F]=5% Nali=20 S619F Neutral 2 0.421 PANTHER: F[S]=19% F[F]=1% S619F Neutral 9 0.065 SNPs&GO S619Y Neutral 7 0.160 PhD-SNP: F[S]=29% F[Y]=0% Nali=20 S619Y Neutral 1 0.458 PANTHER: F[S]=19% F[Y]=0% S619Y Neutral 9 0.073 SNPs&GO S620N Neutral 5 0.239 PhD-SNP: F[S]=81% F[N]=0% Nali=20 S620N Neutral 1 0.434 PANTHER: F[S]=53% F[N]=2% S620N Neutral 7 0.126 SNPs&GO S621T Neutral 8 0.111 PhD-SNP: F[S]=76% F[T]=5% Nali=20 S621T Neutral 4 0.322 PANTHER: F[S]=53% F[T]=4% S621T Neutral 9 0.055 SNPs&GO D622H Neutral 3 0.366 PhD-SNP: F[D]=90% F[H]=0% Nali=19 D622H Disease 3 0.625 PANTHER: F[D]=60% F[H]=1% D622H Neutral 4 0.309 SNPs&GO D622Y Neutral 0 0.490 PhD-SNP: F[D]=90% F[Y]=0% Nali=19 D622Y Disease 5 0.727 PANTHER: F[D]=60% F[Y]=0% D622Y Neutral 2 0.402 SNPs&GO S623N Neutral 7 0.146 PhD-SNP: F[S]=85% F[N]=0% Nali=19 S623N Neutral 1 0.434 PANTHER: F[S]=53% F[N]=2% S623N Neutral 9 0.074 SNPs&GO L624F Neutral 6 0.213 PhD-SNP: F[L]=95% F[F]=0% Nali=19 L624F Neutral 2 0.401 PANTHER: F[L]=59% F[F]=3% L624F Neutral 8 0.113 SNPs&GO L624P Neutral 4 0.306 PhD-SNP: F[L]=95% F[P]=0% Nali=19 L624P Disease 4 0.720 PANTHER: F[L]=59% F[P]=0% L624P Neutral 3 0.327 SNPs&GO S626R Neutral 6 0.181 PhD-SNP: F[S]=67% F[R]=0% Nali=20 S626R Neutral 0 0.483 PANTHER: F[S]=53% F[R]=2% S626R Neutral 8 0.123 SNPs&GO R627C Disease 0 0.510 PhD-SNP: F[R]=67% F[C]=0% Nali=20 R627C Disease 6 0.789 PANTHER: F[R]=58% F[C]=0% R627C Disease 0 0.509 SNPs&GO R627G Neutral 2 0.404 PhD-SNP: F[R]=67% F[G]=0% Nali=20 R627G Disease 0 0.521 PANTHER: F[R]=58% F[G]=2% R627G Neutral 4 0.325 SNPs&GO R627H Neutral 6 0.182 PhD-SNP: F[R]=67% F[H]=14% Nali=20 R627H Disease 2 0.586 PANTHER: F[R]=58% F[H]=1% R627H Neutral 4 0.310 SNPs&GO R627L Neutral 3 0.361 PhD-SNP: F[R]=67% F[L]=10% Nali=20 R627L Neutral 0 0.493 PANTHER: F[R]=58% F[L]=2% R627L Neutral 3 0.360 SNPs&GO G629E Neutral 4 0.322 PhD-SNP: F[G]=71% F[E]=0% Nali=20 G629E Disease 1 0.571 PANTHER: F[G]=71% F[E]=2% G629E Neutral 2 0.414 SNPs&GO G629R Neutral 7 0.148 PhD-SNP: F[G]=71% F[R]=10% Nali=20 G629R Disease 3 0.657 PANTHER: F[G]=71% F[R]=1% G629R Neutral 6 0.220 SNPs&GO G629V Neutral 4 0.294 PhD-SNP: F[G]=71% F[V]=0% Nali=20 G629V Disease 3 0.626 PANTHER: F[G]=71% F[V]=1% G629V Neutral 4 0.298 SNPs&GO S632F Neutral 2 0.404 PhD-SNP: F[S]=81% F[F]=0% Nali=20 S632F Disease 3 0.630 PANTHER: F[S]=53% F[F]=1% S632F Neutral 4 0.317 SNPs&GO S632T Neutral 6 0.185 PhD-SNP: F[S]=81% F[T]=0% Nali=20 S632T Neutral 4 0.322 PANTHER: F[S]=53% F[T]=4% S632T Neutral 8 0.086 SNPs&GO P633L Neutral 0 0.492 PhD-SNP: F[P]=90% F[L]=0% Nali=20 P633L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P633L Neutral 1 0.446 SNPs&GO R634C Disease 2 0.621 PhD-SNP: F[R]=70% F[C]=0% Nali=19 R634C Disease 6 0.789 PANTHER: F[R]=58% F[C]=0% R634C Disease 2 0.624 SNPs&GO R634H Neutral 2 0.379 PhD-SNP: F[R]=70% F[H]=5% Nali=19 R634H Disease 2 0.586 PANTHER: F[R]=58% F[H]=1% R634H Neutral 2 0.424 SNPs&GO R634L Disease 0 0.507 PhD-SNP: F[R]=70% F[L]=10% Nali=19 R634L Neutral 0 0.493 PANTHER: F[R]=58% F[L]=2% R634L Disease 0 0.519 SNPs&GO A638V Neutral 1 0.466 PhD-SNP: F[A]=67% F[V]=0% Nali=20 A638V Neutral 6 0.221 PANTHER: F[A]=29% F[V]=4% A638V Neutral 8 0.120 SNPs&GO P639S Neutral 2 0.422 PhD-SNP: F[P]=89% F[S]=5% Nali=18 P639S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P639S Neutral 2 0.417 SNPs&GO E641D Disease 1 0.572 PhD-SNP: F[E]=86% F[D]=0% Nali=20 E641D Neutral 5 0.269 PANTHER: F[E]=55% F[D]=6% E641D Neutral 4 0.319 SNPs&GO K644E Neutral 2 0.404 PhD-SNP: F[K]=71% F[E]=14% Nali=20 K644E Neutral 3 0.345 PANTHER: F[K]=54% F[E]=4% K644E Neutral 2 0.406 SNPs&GO K646E Disease 3 0.660 PhD-SNP: F[K]=62% F[E]=0% Nali=20 K646E Neutral 3 0.345 PANTHER: F[K]=54% F[E]=4% K646E Disease 1 0.565 SNPs&GO K646R Neutral 4 0.313 PhD-SNP: F[K]=62% F[R]=10% Nali=20 K646R Neutral 5 0.241 PANTHER: F[K]=54% F[R]=7% K646R Neutral 6 0.221 SNPs&GO K648R Neutral 2 0.404 PhD-SNP: F[K]=95% F[R]=5% Nali=20 K648R Neutral 5 0.241 PANTHER: F[K]=54% F[R]=7% K648R Neutral 5 0.271 SNPs&GO Q649E Neutral 2 0.384 PhD-SNP: F[Q]=79% F[E]=0% Nali=18 Q649E Neutral 4 0.304 PANTHER: F[Q]=50% F[E]=4% Q649E Neutral 3 0.349 SNPs&GO Q649L Disease 1 0.546 PhD-SNP: F[Q]=79% F[L]=0% Nali=18 Q649L Neutral 1 0.426 PANTHER: F[Q]=50% F[L]=2% Q649L Neutral 1 0.437 SNPs&GO Q649P Disease 4 0.699 PhD-SNP: F[Q]=79% F[P]=0% Nali=18 Q649P Disease 1 0.566 PANTHER: F[Q]=50% F[P]=1% Q649P Disease 3 0.629 SNPs&GO E650K Disease 4 0.698 PhD-SNP: F[E]=89% F[K]=5% Nali=18 E650K Neutral 3 0.351 PANTHER: F[E]=55% F[K]=4% E650K Disease 1 0.528 SNPs&GO L651M Disease 1 0.568 PhD-SNP: F[L]=95% F[M]=0% Nali=19 L651M Neutral 2 0.388 PANTHER: F[L]=59% F[M]=3% L651M Neutral 5 0.258 SNPs&GO H653P Disease 5 0.755 PhD-SNP: F[H]=35% F[P]=5% Nali=19 H653P Neutral 6 0.217 PANTHER: F[H]=10% F[P]=1% H653P Neutral 5 0.255 SNPs&GO N655K Neutral 3 0.373 PhD-SNP: F[N]=75% F[K]=10% Nali=19 N655K Neutral 3 0.364 PANTHER: F[N]=53% F[K]=3% N655K Neutral 3 0.328 SNPs&GO N655S Neutral 1 0.473 PhD-SNP: F[N]=75% F[S]=0% Nali=19 N655S Neutral 3 0.343 PANTHER: F[N]=53% F[S]=4% N655S Neutral 3 0.355 SNPs&GO S656I Disease 3 0.664 PhD-SNP: F[S]=90% F[I]=0% Nali=19 S656I Disease 1 0.542 PANTHER: F[S]=53% F[I]=1% S656I Neutral 1 0.473 SNPs&GO S657F Disease 0 0.504 PhD-SNP: F[S]=75% F[F]=5% Nali=19 S657F Disease 3 0.630 PANTHER: F[S]=53% F[F]=1% S657F Neutral 2 0.420 SNPs&GO S657P Disease 1 0.558 PhD-SNP: F[S]=75% F[P]=5% Nali=19 S657P Disease 0 0.515 PANTHER: F[S]=53% F[P]=1% S657P Neutral 1 0.456 SNPs&GO P658L Disease 2 0.578 PhD-SNP: F[P]=95% F[L]=0% Nali=19 P658L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P658L Disease 1 0.540 SNPs&GO L660F Neutral 0 0.479 PhD-SNP: F[L]=74% F[F]=0% Nali=18 L660F Neutral 2 0.401 PANTHER: F[L]=59% F[F]=3% L660F Neutral 5 0.274 SNPs&GO L660P Disease 5 0.725 PhD-SNP: F[L]=74% F[P]=0% Nali=18 L660P Disease 4 0.720 PANTHER: F[L]=59% F[P]=0% L660P Disease 3 0.628 SNPs&GO R661G Disease 0 0.509 PhD-SNP: F[R]=79% F[G]=5% Nali=18 R661G Neutral 2 0.380 PANTHER: F[R]=33% F[G]=2% R661G Neutral 5 0.231 SNPs&GO R661P Disease 2 0.587 PhD-SNP: F[R]=79% F[P]=11% Nali=18 R661P Neutral 1 0.462 PANTHER: F[R]=33% F[P]=1% R661P Neutral 2 0.405 SNPs&GO R661Q Disease 4 0.687 PhD-SNP: F[R]=79% F[Q]=0% Nali=18 R661Q Neutral 8 0.119 PANTHER: F[R]=33% F[Q]=12% R661Q Neutral 6 0.210 SNPs&GO R661W Disease 5 0.732 PhD-SNP: F[R]=79% F[W]=0% Nali=18 R661W Disease 5 0.750 PANTHER: F[R]=33% F[W]=0% R661W Disease 0 0.502 SNPs&GO G662A Neutral 8 0.095 PhD-SNP: F[G]=63% F[A]=26% Nali=18 G662A Neutral 2 0.412 PANTHER: F[G]=71% F[A]=4% G662A Neutral 6 0.185 SNPs&GO G662D Disease 4 0.695 PhD-SNP: F[G]=63% F[D]=0% Nali=18 G662D Disease 2 0.580 PANTHER: F[G]=71% F[D]=1% G662D Disease 3 0.672 SNPs&GO H664R Neutral 3 0.364 PhD-SNP: F[H]=63% F[R]=5% Nali=18 H664R Neutral 1 0.426 PANTHER: F[H]=57% F[R]=3% H664R Neutral 5 0.261 SNPs&GO S665P Neutral 9 0.065 PhD-SNP: F[S]=21% F[P]=58% Nali=18 S665P Neutral 9 0.074 PANTHER: F[S]=18% F[P]=28% S665P Neutral 10 0.014 SNPs&GO S665T Neutral 7 0.162 PhD-SNP: F[S]=21% F[T]=0% Nali=18 S665T Neutral 7 0.148 PANTHER: F[S]=18% F[T]=5% S665T Neutral 9 0.030 SNPs&GO L666S Disease 0 0.515 PhD-SNP: F[L]=35% F[S]=0% Nali=16 L666S Neutral 4 0.279 PANTHER: F[L]=22% F[S]=2% L666S Neutral 6 0.175 SNPs&GO E667D Disease 1 0.534 PhD-SNP: F[E]=68% F[D]=0% Nali=18 E667D Neutral 5 0.269 PANTHER: F[E]=55% F[D]=6% E667D Neutral 5 0.243 SNPs&GO E667V Disease 3 0.645 PhD-SNP: F[E]=68% F[V]=0% Nali=18 E667V Disease 1 0.552 PANTHER: F[E]=55% F[V]=1% E667V Neutral 1 0.456 SNPs&GO L668P Disease 5 0.733 PhD-SNP: F[L]=74% F[P]=5% Nali=18 L668P Disease 4 0.720 PANTHER: F[L]=59% F[P]=0% L668P Disease 3 0.648 SNPs&GO R669Q Disease 0 0.509 PhD-SNP: F[R]=37% F[Q]=5% Nali=18 R669Q Neutral 7 0.173 PANTHER: F[R]=16% F[Q]=3% R669Q Neutral 7 0.162 SNPs&GO R669W Neutral 5 0.270 PhD-SNP: F[R]=37% F[W]=42% Nali=18 R669W Disease 3 0.641 PANTHER: F[R]=16% F[W]=0% R669W Neutral 7 0.141 SNPs&GO A670T Disease 2 0.594 PhD-SNP: F[A]=83% F[T]=0% Nali=17 A670T Neutral 7 0.152 PANTHER: F[A]=21% F[T]=5% A670T Neutral 7 0.159 SNPs&GO A670V Neutral 5 0.263 PhD-SNP: F[A]=83% F[V]=17% Nali=17 A670V Neutral 6 0.216 PANTHER: F[A]=21% F[V]=3% A670V Neutral 9 0.060 SNPs&GO N675S Neutral 4 0.286 PhD-SNP: F[N]=67% F[S]=17% Nali=17 N675S Neutral 3 0.343 PANTHER: F[N]=53% F[S]=4% N675S Neutral 6 0.207 SNPs&GO G677V Disease 4 0.716 PhD-SNP: F[G]=71% F[V]=0% Nali=16 G677V Neutral 6 0.203 PANTHER: F[G]=16% F[V]=3% G677V Neutral 5 0.238 SNPs&GO S678T Neutral 1 0.471 PhD-SNP: F[S]=74% F[T]=0% Nali=18 S678T Neutral 7 0.135 PANTHER: F[S]=14% F[T]=4% S678T Neutral 8 0.095 SNPs&GO K679N Disease 4 0.678 PhD-SNP: F[K]=74% F[N]=0% Nali=18 K679N Neutral 7 0.157 PANTHER: F[K]=16% F[N]=4% K679N Neutral 6 0.194 SNPs&GO N680I Disease 4 0.698 PhD-SNP: F[N]=74% F[I]=0% Nali=18 N680I Neutral 4 0.278 PANTHER: F[N]=15% F[I]=1% N680I Neutral 5 0.263 SNPs&GO N680K Disease 2 0.580 PhD-SNP: F[N]=74% F[K]=5% Nali=18 N680K Neutral 7 0.127 PANTHER: F[N]=15% F[K]=5% N680K Neutral 6 0.180 SNPs&GO N680Y Disease 4 0.717 PhD-SNP: F[N]=74% F[Y]=0% Nali=18 N680Y Neutral 3 0.351 PANTHER: F[N]=15% F[Y]=1% N680Y Neutral 5 0.273 SNPs&GO L681F Neutral 6 0.194 PhD-SNP: F[L]=58% F[F]=21% Nali=18 L681F Neutral 5 0.268 PANTHER: F[L]=16% F[F]=2% L681F Neutral 8 0.076 SNPs&GO L681I Neutral 3 0.327 PhD-SNP: F[L]=58% F[I]=5% Nali=18 L681I Neutral 7 0.169 PANTHER: F[L]=16% F[I]=3% L681I Neutral 8 0.091 SNPs&GO S684N Disease 1 0.570 PhD-SNP: F[S]=84% F[N]=0% Nali=18 S684N Neutral 3 0.331 PANTHER: F[S]=36% F[N]=3% S684N Neutral 4 0.291 SNPs&GO P685T Disease 2 0.617 PhD-SNP: F[P]=95% F[T]=0% Nali=18 P685T Neutral 8 0.112 PANTHER: F[P]=13% F[T]=5% P685T Neutral 7 0.168 SNPs&GO G686R Disease 6 0.796 PhD-SNP: F[G]=95% F[R]=0% Nali=18 G686R Neutral 5 0.265 PANTHER: F[G]=18% F[R]=2% G686R Disease 1 0.542 SNPs&GO A687D Disease 5 0.758 PhD-SNP: F[A]=63% F[D]=0% Nali=18 A687D Neutral 7 0.168 PANTHER: F[A]=16% F[D]=3% A687D Neutral 5 0.251 SNPs&GO A687G Neutral 6 0.194 PhD-SNP: F[A]=63% F[G]=16% Nali=18 A687G Neutral 9 0.054 PANTHER: F[A]=16% F[G]=16% A687G Neutral 10 0.020 SNPs&GO V688A Neutral 5 0.247 PhD-SNP: F[V]=74% F[A]=16% Nali=18 V688A Neutral 8 0.104 PANTHER: F[V]=13% F[A]=5% V688A Neutral 8 0.085 SNPs&GO P689S Neutral 1 0.444 PhD-SNP: F[P]=84% F[S]=11% Nali=18 P689S Neutral 9 0.073 PANTHER: F[P]=33% F[S]=6% P689S Neutral 7 0.163 SNPs&GO Q690K Disease 2 0.583 PhD-SNP: F[Q]=42% F[K]=0% Nali=18 Q690K Neutral 9 0.040 PANTHER: F[Q]=22% F[K]=8% Q690K Neutral 7 0.136 SNPs&GO V693A Neutral 5 0.257 PhD-SNP: F[V]=79% F[A]=11% Nali=18 V693A Neutral 9 0.065 PANTHER: F[V]=30% F[A]=6% V693A Neutral 8 0.105 SNPs&GO A694P Disease 0 0.501 PhD-SNP: F[A]=63% F[P]=11% Nali=18 A694P Disease 1 0.539 PANTHER: F[A]=55% F[P]=1% A694P Neutral 1 0.468 SNPs&GO A694T Neutral 1 0.458 PhD-SNP: F[A]=63% F[T]=0% Nali=18 A694T Neutral 3 0.338 PANTHER: F[A]=55% F[T]=4% A694T Neutral 3 0.335 SNPs&GO R696G Disease 3 0.653 PhD-SNP: F[R]=84% F[G]=0% Nali=18 R696G Neutral 7 0.132 PANTHER: F[R]=35% F[G]=11% R696G Neutral 7 0.142 SNPs&GO R696Q Disease 4 0.704 PhD-SNP: F[R]=84% F[Q]=0% Nali=18 R696Q Neutral 5 0.263 PANTHER: F[R]=35% F[Q]=4% R696Q Neutral 3 0.344 SNPs&GO R696W Disease 6 0.783 PhD-SNP: F[R]=84% F[W]=0% Nali=18 R696W Disease 5 0.767 PANTHER: F[R]=35% F[W]=0% R696W Disease 2 0.577 SNPs&GO A697S Neutral 4 0.308 PhD-SNP: F[A]=74% F[S]=11% Nali=18 A697S Neutral 4 0.280 PANTHER: F[A]=55% F[S]=6% A697S Neutral 6 0.203 SNPs&GO L698M Neutral 1 0.470 PhD-SNP: F[L]=76% F[M]=0% Nali=16 L698M Neutral 8 0.107 PANTHER: F[L]=34% F[M]=4% L698M Neutral 9 0.065 SNPs&GO G699R Disease 5 0.771 PhD-SNP: F[G]=94% F[R]=0% Nali=16 G699R Neutral 7 0.145 PANTHER: F[G]=38% F[R]=3% G699R Neutral 2 0.415 SNPs&GO P700L Disease 5 0.761 PhD-SNP: F[P]=94% F[L]=0% Nali=16 P700L Neutral 8 0.103 PANTHER: F[P]=33% F[L]=4% P700L Neutral 5 0.269 SNPs&GO L702F Disease 0 0.509 PhD-SNP: F[L]=78% F[F]=6% Nali=17 L702F Neutral 8 0.100 PANTHER: F[L]=34% F[F]=4% L702F Neutral 7 0.134 SNPs&GO L702I Neutral 4 0.322 PhD-SNP: F[L]=78% F[I]=11% Nali=17 L702I Neutral 9 0.052 PANTHER: F[L]=34% F[I]=10% L702I Neutral 8 0.078 SNPs&GO L702P Disease 6 0.822 PhD-SNP: F[L]=78% F[P]=0% Nali=17 L702P Neutral 5 0.243 PANTHER: F[L]=34% F[P]=1% L702P Neutral 1 0.450 SNPs&GO L702R Disease 6 0.823 PhD-SNP: F[L]=78% F[R]=0% Nali=17 L702R Neutral 7 0.148 PANTHER: F[L]=34% F[R]=2% L702R Neutral 2 0.383 SNPs&GO L702V Disease 0 0.513 PhD-SNP: F[L]=78% F[V]=0% Nali=17 L702V Neutral 9 0.052 PANTHER: F[L]=34% F[V]=10% L702V Neutral 8 0.089 SNPs&GO S705F Disease 1 0.549 PhD-SNP: F[S]=50% F[F]=0% Nali=17 S705F Disease 1 0.570 PANTHER: F[S]=38% F[F]=1% S705F Neutral 2 0.389 SNPs&GO S705T Neutral 4 0.281 PhD-SNP: F[S]=50% F[T]=0% Nali=17 S705T Neutral 5 0.229 PANTHER: F[S]=38% F[T]=5% S705T Neutral 8 0.089 SNPs&GO N707K Neutral 3 0.340 PhD-SNP: F[N]=39% F[K]=0% Nali=17 N707K Neutral 9 0.061 PANTHER: F[N]=12% F[K]=10% N707K Neutral 9 0.054 SNPs&GO E708D Disease 0 0.506 PhD-SNP: F[E]=78% F[D]=0% Nali=17 E708D Neutral 8 0.118 PANTHER: F[E]=16% F[D]=6% E708D Neutral 9 0.074 SNPs&GO E708G Neutral 0 0.495 PhD-SNP: F[E]=78% F[G]=0% Nali=17 E708G Neutral 6 0.182 PANTHER: F[E]=16% F[G]=3% E708G Neutral 9 0.062 SNPs&GO L709V Neutral 3 0.360 PhD-SNP: F[L]=89% F[V]=0% Nali=17 L709V Neutral 9 0.059 PANTHER: F[L]=31% F[V]=27% L709V Neutral 9 0.031 SNPs&GO V710G Disease 1 0.563 PhD-SNP: F[V]=53% F[G]=0% Nali=16 V710G Neutral 8 0.083 PANTHER: F[V]=17% F[G]=29% V710G Neutral 9 0.030 SNPs&GO T711A Neutral 6 0.191 PhD-SNP: F[T]=47% F[A]=6% Nali=16 T711A Unclassified NA NA PANTHER: F[T]=NA F[A]=NA T711A Neutral 9 0.064 SNPs&GO T711I Neutral 1 0.474 PhD-SNP: F[T]=47% F[I]=0% Nali=16 T711I Unclassified NA NA PANTHER: F[T]=NA F[I]=NA T711I Neutral 7 0.141 SNPs&GO T711S Neutral 9 0.070 PhD-SNP: F[T]=47% F[S]=29% Nali=16 T711S Unclassified NA NA PANTHER: F[T]=NA F[S]=NA T711S Neutral 10 0.016 SNPs&GO R712C Neutral 0 0.494 PhD-SNP: F[R]=61% F[C]=6% Nali=17 R712C Neutral 0 0.479 PANTHER: F[R]=17% F[C]=0% R712C Neutral 6 0.189 SNPs&GO R712G Neutral 1 0.457 PhD-SNP: F[R]=61% F[G]=0% Nali=17 R712G Neutral 6 0.213 PANTHER: F[R]=17% F[G]=2% R712G Neutral 8 0.091 SNPs&GO R712H Neutral 2 0.409 PhD-SNP: F[R]=61% F[H]=6% Nali=17 R712H Neutral 4 0.283 PANTHER: F[R]=17% F[H]=1% R712H Neutral 7 0.163 SNPs&GO H713Y Neutral 3 0.329 PhD-SNP: F[H]=28% F[Y]=0% Nali=17 H713Y Neutral 6 0.209 PANTHER: F[H]=10% F[Y]=1% H713Y Neutral 8 0.076 SNPs&GO P715L Disease 1 0.558 PhD-SNP: F[P]=76% F[L]=0% Nali=16 P715L Neutral 7 0.153 PANTHER: F[P]=12% F[L]=3% P715L Neutral 7 0.146 SNPs&GO P715S Neutral 3 0.330 PhD-SNP: F[P]=76% F[S]=12% Nali=16 P715S Neutral 8 0.107 PANTHER: F[P]=12% F[S]=5% P715S Neutral 8 0.090 SNPs&GO P718H Disease 3 0.644 PhD-SNP: F[P]=100% F[H]=0% Nali=16 P718H Neutral 4 0.302 PANTHER: F[P]=13% F[H]=1% P718H Neutral 6 0.218 SNPs&GO P718L Disease 1 0.555 PhD-SNP: F[P]=100% F[L]=0% Nali=16 P718L Neutral 6 0.192 PANTHER: F[P]=13% F[L]=2% P718L Neutral 6 0.176 SNPs&GO P718T Disease 1 0.557 PhD-SNP: F[P]=100% F[T]=0% Nali=16 P718T Neutral 8 0.112 PANTHER: F[P]=13% F[T]=5% P718T Neutral 7 0.148 SNPs&GO L719F Neutral 1 0.446 PhD-SNP: F[L]=94% F[F]=0% Nali=16 L719F Neutral 5 0.227 PANTHER: F[L]=15% F[F]=2% L719F Neutral 8 0.110 SNPs&GO L719P Neutral 2 0.422 PhD-SNP: F[L]=94% F[P]=6% Nali=16 L719P Neutral 5 0.272 PANTHER: F[L]=15% F[P]=1% L719P Neutral 7 0.132 SNPs&GO P721L Neutral 6 0.184 PhD-SNP: F[P]=75% F[L]=13% Nali=15 P721L Neutral 7 0.127 PANTHER: F[P]=11% F[L]=33% P721L Neutral 10 0.019 SNPs&GO T724A Neutral 10 0.022 PhD-SNP: F[T]=29% F[A]=18% Nali=16 T724A Neutral 8 0.104 PANTHER: F[T]=13% F[A]=5% T724A Neutral 10 0.013 SNPs&GO T724I Neutral 8 0.105 PhD-SNP: F[T]=29% F[I]=0% Nali=16 T724I Neutral 6 0.204 PANTHER: F[T]=13% F[I]=2% T724I Neutral 9 0.030 SNPs&GO T724S Neutral 9 0.054 PhD-SNP: F[T]=29% F[S]=6% Nali=16 T724S Neutral 8 0.111 PANTHER: F[T]=13% F[S]=5% T724S Neutral 10 0.014 SNPs&GO P725H Neutral 5 0.264 PhD-SNP: F[P]=54% F[H]=0% Nali=12 P725H Disease 5 0.762 PANTHER: F[P]=70% F[H]=0% P725H Neutral 1 0.461 SNPs&GO P725S Neutral 6 0.176 PhD-SNP: F[P]=54% F[S]=0% Nali=12 P725S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P725S Neutral 5 0.261 SNPs&GO T727A Neutral 8 0.103 PhD-SNP: F[T]=59% F[A]=0% Nali=16 T727A Unclassified NA NA PANTHER: F[T]=NA F[A]=NA T727A Neutral 9 0.035 SNPs&GO T727N Neutral 7 0.171 PhD-SNP: F[T]=59% F[N]=6% Nali=16 T727N Unclassified NA NA PANTHER: F[T]=NA F[N]=NA T727N Neutral 9 0.042 SNPs&GO T727P Neutral 4 0.320 PhD-SNP: F[T]=59% F[P]=0% Nali=16 T727P Unclassified NA NA PANTHER: F[T]=NA F[P]=NA T727P Neutral 9 0.073 SNPs&GO S729G Neutral 9 0.065 PhD-SNP: F[S]=65% F[G]=12% Nali=16 S729G Unclassified NA NA PANTHER: F[S]=NA F[G]=NA S729G Neutral 10 0.015 SNPs&GO S729N Neutral 5 0.262 PhD-SNP: F[S]=65% F[N]=0% Nali=16 S729N Unclassified NA NA PANTHER: F[S]=NA F[N]=NA S729N Neutral 9 0.051 SNPs&GO Q731H Neutral 5 0.272 PhD-SNP: F[Q]=88% F[H]=0% Nali=15 Q731H Unclassified NA NA PANTHER: F[Q]=NA F[H]=NA Q731H Neutral 9 0.047 SNPs&GO T732I Neutral 8 0.103 PhD-SNP: F[T]=56% F[I]=0% Nali=15 T732I Unclassified NA NA PANTHER: F[T]=NA F[I]=NA T732I Neutral 9 0.027 SNPs&GO T732N Neutral 8 0.113 PhD-SNP: F[T]=56% F[N]=6% Nali=15 T732N Unclassified NA NA PANTHER: F[T]=NA F[N]=NA T732N Neutral 9 0.027 SNPs&GO Q733K Neutral 6 0.209 PhD-SNP: F[Q]=81% F[K]=0% Nali=15 Q733K Neutral 8 0.095 PANTHER: F[Q]=14% F[K]=7% Q733K Neutral 9 0.042 SNPs&GO P735L Neutral 8 0.092 PhD-SNP: F[P]=50% F[L]=6% Nali=15 P735L Neutral 7 0.156 PANTHER: F[P]=13% F[L]=3% P735L Neutral 9 0.031 SNPs&GO V736A Neutral 8 0.078 PhD-SNP: F[V]=25% F[A]=6% Nali=15 V736A Neutral 9 0.065 PANTHER: F[V]=30% F[A]=6% V736A Neutral 9 0.038 SNPs&GO P738L Neutral 8 0.124 PhD-SNP: F[P]=69% F[L]=19% Nali=15 P738L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P738L Neutral 4 0.281 SNPs&GO A740D Disease 4 0.675 PhD-SNP: F[A]=71% F[D]=0% Nali=16 A740D Neutral 8 0.092 PANTHER: F[A]=15% F[D]=30% A740D Neutral 9 0.040 SNPs&GO A740P Disease 3 0.648 PhD-SNP: F[A]=71% F[P]=0% Nali=16 A740P Neutral 5 0.265 PANTHER: F[A]=15% F[P]=1% A740P Neutral 6 0.208 SNPs&GO A740T Neutral 1 0.452 PhD-SNP: F[A]=71% F[T]=0% Nali=16 A740T Neutral 7 0.158 PANTHER: F[A]=15% F[T]=4% A740T Neutral 8 0.120 SNPs&GO A740V Neutral 5 0.238 PhD-SNP: F[A]=71% F[V]=12% Nali=16 A740V Neutral 6 0.222 PANTHER: F[A]=15% F[V]=2% A740V Neutral 9 0.056 SNPs&GO P741A Neutral 8 0.102 PhD-SNP: F[P]=88% F[A]=12% Nali=16 P741A Neutral 1 0.435 PANTHER: F[P]=70% F[A]=3% P741A Neutral 7 0.129 SNPs&GO S742F Disease 1 0.549 PhD-SNP: F[S]=76% F[F]=0% Nali=16 S742F Neutral 3 0.340 PANTHER: F[S]=14% F[F]=1% S742F Neutral 6 0.197 SNPs&GO S742P Neutral 4 0.295 PhD-SNP: F[S]=76% F[P]=12% Nali=16 S742P Neutral 5 0.252 PANTHER: F[S]=14% F[P]=1% S742P Neutral 8 0.107 SNPs&GO S743P Neutral 5 0.240 PhD-SNP: F[S]=67% F[P]=13% Nali=14 S743P Disease 0 0.515 PANTHER: F[S]=53% F[P]=1% S743P Neutral 4 0.287 SNPs&GO S743T Neutral 5 0.241 PhD-SNP: F[S]=67% F[T]=0% Nali=14 S743T Neutral 4 0.322 PANTHER: F[S]=53% F[T]=4% S743T Neutral 7 0.149 SNPs&GO I744L Neutral 8 0.101 PhD-SNP: F[I]=31% F[L]=19% Nali=15 I744L Neutral 8 0.084 PANTHER: F[I]=12% F[L]=7% I744L Neutral 9 0.038 SNPs&GO I744N Disease 0 0.506 PhD-SNP: F[I]=31% F[N]=0% Nali=15 I744N Neutral 7 0.158 PANTHER: F[I]=12% F[N]=3% I744N Neutral 7 0.140 SNPs&GO I744T Neutral 4 0.283 PhD-SNP: F[I]=31% F[T]=0% Nali=15 I744T Neutral 7 0.129 PANTHER: F[I]=12% F[T]=4% I744T Neutral 9 0.061 SNPs&GO L745M Neutral 4 0.278 PhD-SNP: F[L]=38% F[M]=0% Nali=15 L745M Neutral 5 0.229 PANTHER: F[L]=20% F[M]=3% L745M Neutral 9 0.033 SNPs&GO A749D Disease 3 0.674 PhD-SNP: F[A]=65% F[D]=0% Nali=16 A749D Neutral 7 0.134 PANTHER: F[A]=15% F[D]=4% A749D Neutral 8 0.109 SNPs&GO A749L Disease 1 0.547 PhD-SNP: F[A]=65% F[L]=0% Nali=16 A749L Neutral 7 0.171 PANTHER: F[A]=15% F[L]=3% A749L Neutral 8 0.123 SNPs&GO A749T Neutral 2 0.394 PhD-SNP: F[A]=65% F[T]=0% Nali=16 A749T Neutral 7 0.137 PANTHER: F[A]=15% F[T]=4% A749T Neutral 8 0.078 SNPs&GO A749V Neutral 1 0.452 PhD-SNP: F[A]=65% F[V]=0% Nali=16 A749V Neutral 7 0.174 PANTHER: F[A]=15% F[V]=3% A749V Neutral 9 0.060 SNPs&GO P750S Neutral 6 0.200 PhD-SNP: F[P]=64% F[S]=7% Nali=13 P750S Neutral 8 0.089 PANTHER: F[P]=13% F[S]=7% P750S Neutral 9 0.028 SNPs&GO I751N Neutral 0 0.483 PhD-SNP: F[I]=50% F[N]=0% Nali=13 I751N Neutral 5 0.232 PANTHER: F[I]=16% F[N]=2% I751N Neutral 7 0.146 SNPs&GO P752L Neutral 7 0.154 PhD-SNP: F[P]=36% F[L]=7% Nali=13 P752L Neutral 6 0.192 PANTHER: F[P]=13% F[L]=2% P752L Neutral 9 0.044 SNPs&GO P752T Neutral 8 0.116 PhD-SNP: F[P]=36% F[T]=0% Nali=13 P752T Neutral 8 0.112 PANTHER: F[P]=13% F[T]=5% P752T Neutral 10 0.016 SNPs&GO I753N Neutral 4 0.308 PhD-SNP: F[I]=43% F[N]=7% Nali=13 I753N Neutral 6 0.196 PANTHER: F[I]=14% F[N]=2% I753N Neutral 8 0.096 SNPs&GO I753V Neutral 9 0.037 PhD-SNP: F[I]=43% F[V]=21% Nali=13 I753V Neutral 8 0.093 PANTHER: F[I]=14% F[V]=7% I753V Neutral 10 0.008 SNPs&GO L754H Neutral 3 0.375 PhD-SNP: F[L]=50% F[H]=0% Nali=13 L754H Neutral 5 0.245 PANTHER: F[L]=13% F[H]=1% L754H Neutral 9 0.056 SNPs&GO L754P Neutral 3 0.336 PhD-SNP: F[L]=50% F[P]=7% Nali=13 L754P Neutral 5 0.259 PANTHER: F[L]=13% F[P]=1% L754P Neutral 9 0.059 SNPs&GO C757S Neutral 8 0.112 PhD-SNP: F[C]=38% F[S]=19% Nali=15 C757S Neutral 8 0.115 PANTHER: F[C]=13% F[S]=35% C757S Neutral 10 0.010 SNPs&GO C757Y Neutral 3 0.361 PhD-SNP: F[C]=38% F[Y]=0% Nali=15 C757Y Neutral 3 0.339 PANTHER: F[C]=13% F[Y]=1% C757Y Neutral 8 0.122 SNPs&GO S758N Neutral 9 0.074 PhD-SNP: F[S]=44% F[N]=13% Nali=15 S758N Neutral 7 0.156 PANTHER: F[S]=14% F[N]=3% S758N Neutral 10 0.022 SNPs&GO S758T Neutral 8 0.082 PhD-SNP: F[S]=44% F[T]=6% Nali=15 S758T Neutral 7 0.138 PANTHER: F[S]=14% F[T]=4% S758T Neutral 10 0.017 SNPs&GO P759A Neutral 9 0.070 PhD-SNP: F[P]=59% F[A]=0% Nali=16 P759A Neutral 1 0.435 PANTHER: F[P]=70% F[A]=3% P759A Neutral 8 0.093 SNPs&GO P759L Neutral 7 0.128 PhD-SNP: F[P]=59% F[L]=6% Nali=16 P759L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P759L Neutral 5 0.264 SNPs&GO P759R Neutral 6 0.199 PhD-SNP: F[P]=59% F[R]=0% Nali=16 P759R Disease 2 0.622 PANTHER: F[P]=70% F[R]=1% P759R Neutral 4 0.289 SNPs&GO P759S Neutral 7 0.161 PhD-SNP: F[P]=59% F[S]=0% Nali=16 P759S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P759S Neutral 6 0.201 SNPs&GO P759T Neutral 8 0.079 PhD-SNP: F[P]=59% F[T]=12% Nali=16 P759T Disease 1 0.541 PANTHER: F[P]=70% F[T]=2% P759T Neutral 7 0.139 SNPs&GO P760L Neutral 7 0.138 PhD-SNP: F[P]=29% F[L]=0% Nali=16 P760L Neutral 6 0.192 PANTHER: F[P]=13% F[L]=2% P760L Neutral 9 0.042 SNPs&GO S761R Neutral 6 0.203 PhD-SNP: F[S]=71% F[R]=0% Nali=16 S761R Neutral 0 0.483 PANTHER: F[S]=53% F[R]=2% S761R Neutral 6 0.205 SNPs&GO S761T Neutral 8 0.081 PhD-SNP: F[S]=71% F[T]=6% Nali=16 S761T Neutral 4 0.322 PANTHER: F[S]=53% F[T]=4% S761T Neutral 9 0.065 SNPs&GO P762L Neutral 7 0.150 PhD-SNP: F[P]=82% F[L]=6% Nali=16 P762L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P762L Neutral 5 0.264 SNPs&GO P762S Neutral 6 0.212 PhD-SNP: F[P]=82% F[S]=0% Nali=16 P762S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P762S Neutral 5 0.251 SNPs&GO P762T Neutral 6 0.189 PhD-SNP: F[P]=82% F[T]=0% Nali=16 P762T Disease 1 0.541 PANTHER: F[P]=70% F[T]=2% P762T Neutral 5 0.232 SNPs&GO Q763H Neutral 8 0.091 PhD-SNP: F[Q]=63% F[H]=0% Nali=15 Q763H Disease 1 0.549 PANTHER: F[Q]=50% F[H]=1% Q763H Neutral 7 0.129 SNPs&GO A764V Neutral 9 0.069 PhD-SNP: F[A]=63% F[V]=6% Nali=15 A764V Neutral 3 0.372 PANTHER: F[A]=55% F[V]=3% A764V Neutral 9 0.057 SNPs&GO S766F Neutral 8 0.110 PhD-SNP: F[S]=81% F[F]=6% Nali=15 S766F Neutral 8 0.090 PANTHER: F[S]=14% F[F]=28% S766F Neutral 10 0.006 SNPs&GO S768C Neutral 8 0.113 PhD-SNP: F[S]=56% F[C]=0% Nali=15 S768C Disease 2 0.623 PANTHER: F[S]=53% F[C]=1% S768C Neutral 7 0.136 SNPs&GO G769D Neutral 4 0.283 PhD-SNP: F[G]=69% F[D]=0% Nali=15 G769D Neutral 5 0.272 PANTHER: F[G]=13% F[D]=1% G769D Neutral 8 0.116 SNPs&GO G769S Neutral 8 0.080 PhD-SNP: F[G]=69% F[S]=13% Nali=15 G769S Neutral 8 0.095 PANTHER: F[G]=13% F[S]=6% G769S Neutral 9 0.029 SNPs&GO P770L Neutral 9 0.066 PhD-SNP: F[P]=69% F[L]=13% Nali=15 P770L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P770L Neutral 6 0.178 SNPs&GO P770S Neutral 7 0.127 PhD-SNP: F[P]=69% F[S]=0% Nali=15 P770S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P770S Neutral 6 0.197 SNPs&GO S771N Neutral 8 0.099 PhD-SNP: F[S]=88% F[N]=0% Nali=15 S771N Neutral 1 0.434 PANTHER: F[S]=53% F[N]=2% S771N Neutral 9 0.071 SNPs&GO A773P Neutral 6 0.215 PhD-SNP: F[A]=44% F[P]=0% Nali=15 A773P Unclassified NA NA PANTHER: F[A]=NA F[P]=NA A773P Neutral 9 0.039 SNPs&GO A773T Neutral 9 0.042 PhD-SNP: F[A]=44% F[T]=6% Nali=15 A773T Unclassified NA NA PANTHER: F[A]=NA F[T]=NA A773T Neutral 10 0.009 SNPs&GO A773V Neutral 8 0.077 PhD-SNP: F[A]=44% F[V]=0% Nali=15 A773V Unclassified NA NA PANTHER: F[A]=NA F[V]=NA A773V Neutral 10 0.015 SNPs&GO R776C Neutral 5 0.254 PhD-SNP: F[R]=53% F[C]=0% Nali=14 R776C Neutral 2 0.412 PANTHER: F[R]=14% F[C]=0% R776C Neutral 9 0.070 SNPs&GO R776H Neutral 8 0.082 PhD-SNP: F[R]=53% F[H]=13% Nali=14 R776H Neutral 5 0.251 PANTHER: F[R]=14% F[H]=1% R776H Neutral 9 0.047 SNPs&GO R776P Neutral 3 0.337 PhD-SNP: F[R]=53% F[P]=0% Nali=14 R776P Neutral 5 0.257 PANTHER: F[R]=14% F[P]=1% R776P Neutral 8 0.103 SNPs&GO S778P Neutral 8 0.125 PhD-SNP: F[S]=88% F[P]=6% Nali=15 S778P Disease 0 0.515 PANTHER: F[S]=53% F[P]=1% S778P Neutral 7 0.131 SNPs&GO S779G Neutral 8 0.079 PhD-SNP: F[S]=75% F[G]=0% Nali=15 S779G Neutral 6 0.189 PANTHER: F[S]=14% F[G]=2% S779G Neutral 10 0.008 SNPs&GO S779I Neutral 6 0.213 PhD-SNP: F[S]=75% F[I]=0% Nali=15 S779I Neutral 8 0.109 PANTHER: F[S]=14% F[I]=5% S779I Neutral 10 0.019 SNPs&GO S780F Neutral 6 0.211 PhD-SNP: F[S]=69% F[F]=0% Nali=15 S780F Disease 3 0.630 PANTHER: F[S]=53% F[F]=1% S780F Neutral 6 0.187 SNPs&GO L785R Neutral 1 0.442 PhD-SNP: F[L]=53% F[R]=0% Nali=16 L785R Neutral 7 0.130 PANTHER: F[L]=13% F[R]=4% L785R Neutral 9 0.064 SNPs&GO G786E Neutral 8 0.103 PhD-SNP: F[G]=44% F[E]=25% Nali=15 G786E Neutral 9 0.049 PANTHER: F[G]=17% F[E]=10% G786E Neutral 9 0.041 SNPs&GO G786R Neutral 5 0.274 PhD-SNP: F[G]=44% F[R]=0% Nali=15 G786R Neutral 8 0.121 PANTHER: F[G]=17% F[R]=3% G786R Neutral 9 0.060 SNPs&GO E787K Neutral 4 0.287 PhD-SNP: F[E]=69% F[K]=0% Nali=15 E787K Neutral 7 0.170 PANTHER: F[E]=31% F[K]=7% E787K Neutral 9 0.075 SNPs&GO D788G Neutral 2 0.414 PhD-SNP: F[D]=88% F[G]=0% Nali=15 D788G Neutral 3 0.337 PANTHER: F[D]=53% F[G]=3% D788G Neutral 7 0.168 SNPs&GO D788H Neutral 2 0.419 PhD-SNP: F[D]=88% F[H]=0% Nali=15 D788H Disease 0 0.501 PANTHER: F[D]=53% F[H]=1% D788H Neutral 5 0.274 SNPs&GO Q789E Neutral 4 0.299 PhD-SNP: F[Q]=71% F[E]=0% Nali=16 Q789E Neutral 6 0.203 PANTHER: F[Q]=42% F[E]=5% Q789E Neutral 7 0.149 SNPs&GO D790N Disease 0 0.523 PhD-SNP: F[D]=100% F[N]=0% Nali=17 D790N Neutral 2 0.383 PANTHER: F[D]=60% F[N]=3% D790N Neutral 3 0.330 SNPs&GO D790Y Disease 4 0.721 PhD-SNP: F[D]=100% F[Y]=0% Nali=17 D790Y Disease 5 0.727 PANTHER: F[D]=60% F[Y]=0% D790Y Disease 2 0.606 SNPs&GO S791N Neutral 7 0.151 PhD-SNP: F[S]=61% F[N]=17% Nali=17 S791N Neutral 1 0.434 PANTHER: F[S]=53% F[N]=2% S791N Neutral 6 0.207 SNPs&GO V792M Disease 1 0.534 PhD-SNP: F[V]=83% F[M]=0% Nali=17 V792M Neutral 1 0.473 PANTHER: F[V]=52% F[M]=2% V792M Neutral 4 0.295 SNPs&GO T794A Neutral 3 0.341 PhD-SNP: F[T]=83% F[A]=6% Nali=17 T794A Neutral 5 0.246 PANTHER: F[T]=51% F[A]=7% T794A Neutral 5 0.227 SNPs&GO E796D Neutral 0 0.484 PhD-SNP: F[E]=72% F[D]=0% Nali=17 E796D Neutral 5 0.269 PANTHER: F[E]=55% F[D]=6% E796D Neutral 5 0.232 SNPs&GO E796K Disease 3 0.641 PhD-SNP: F[E]=72% F[K]=0% Nali=17 E796K Neutral 3 0.351 PANTHER: F[E]=55% F[K]=4% E796K Neutral 1 0.436 SNPs&GO E797D Neutral 7 0.157 PhD-SNP: F[E]=56% F[D]=17% Nali=17 E797D Neutral 5 0.269 PANTHER: F[E]=55% F[D]=6% E797D Neutral 8 0.124 SNPs&GO V798A Disease 0 0.517 PhD-SNP: F[V]=83% F[A]=0% Nali=17 V798A Neutral 3 0.331 PANTHER: F[V]=52% F[A]=4% V798A Neutral 3 0.362 SNPs&GO V798E Disease 6 0.789 PhD-SNP: F[V]=83% F[E]=0% Nali=17 V798E Disease 2 0.596 PANTHER: F[V]=52% F[E]=1% V798E Disease 4 0.722 SNPs&GO V798I Neutral 3 0.359 PhD-SNP: F[V]=83% F[I]=0% Nali=17 V798I Neutral 7 0.168 PANTHER: F[V]=52% F[I]=12% V798I Neutral 8 0.125 SNPs&GO A799D Disease 5 0.744 PhD-SNP: F[A]=89% F[D]=0% Nali=17 A799D Disease 0 0.515 PANTHER: F[A]=55% F[D]=2% A799D Disease 1 0.528 SNPs&GO A799S Disease 1 0.573 PhD-SNP: F[A]=89% F[S]=0% Nali=17 A799S Neutral 4 0.280 PANTHER: F[A]=55% F[S]=6% A799S Neutral 4 0.308 SNPs&GO A799V Disease 0 0.513 PhD-SNP: F[A]=89% F[V]=0% Nali=17 A799V Neutral 3 0.372 PANTHER: F[A]=55% F[V]=3% A799V Neutral 5 0.263 SNPs&GO C801Y Neutral 0 0.498 PhD-SNP: F[C]=61% F[Y]=22% Nali=17 C801Y Disease 4 0.717 PANTHER: F[C]=65% F[Y]=0% C801Y Disease 2 0.602 SNPs&GO L802F Neutral 1 0.437 PhD-SNP: F[L]=89% F[F]=0% Nali=17 L802F Neutral 2 0.401 PANTHER: F[L]=59% F[F]=3% L802F Neutral 5 0.269 SNPs&GO L804P Disease 5 0.743 PhD-SNP: F[L]=72% F[P]=0% Nali=17 L804P Disease 4 0.720 PANTHER: F[L]=59% F[P]=0% L804P Disease 4 0.714 SNPs&GO E806A Neutral 3 0.370 PhD-SNP: F[E]=35% F[A]=0% Nali=16 E806A Neutral 6 0.192 PANTHER: F[E]=21% F[A]=4% E806A Neutral 8 0.081 SNPs&GO E806K Disease 1 0.529 PhD-SNP: F[E]=35% F[K]=0% Nali=16 E806K Neutral 7 0.174 PANTHER: F[E]=21% F[K]=4% E806K Neutral 7 0.162 SNPs&GO G807R Disease 1 0.571 PhD-SNP: F[G]=71% F[R]=0% Nali=16 G807R Disease 3 0.657 PANTHER: F[G]=71% F[R]=1% G807R Disease 1 0.561 SNPs&GO G807S Disease 2 0.581 PhD-SNP: F[G]=71% F[S]=0% Nali=16 G807S Neutral 1 0.452 PANTHER: F[G]=71% F[S]=3% G807S Disease 0 0.507 SNPs&GO E808K Disease 1 0.537 PhD-SNP: F[E]=59% F[K]=0% Nali=16 E808K Neutral 3 0.351 PANTHER: F[E]=55% F[K]=4% E808K Neutral 2 0.391 SNPs&GO E809K Disease 2 0.581 PhD-SNP: F[E]=65% F[K]=0% Nali=16 E809K Neutral 3 0.351 PANTHER: F[E]=55% F[K]=4% E809K Neutral 1 0.425 SNPs&GO P811A Neutral 4 0.308 PhD-SNP: F[P]=76% F[A]=0% Nali=16 P811A Neutral 1 0.435 PANTHER: F[P]=70% F[A]=3% P811A Neutral 4 0.317 SNPs&GO R812M Neutral 0 0.499 PhD-SNP: F[R]=71% F[M]=0% Nali=16 R812M Neutral 4 0.290 PANTHER: F[R]=15% F[M]=1% R812M Neutral 8 0.109 SNPs&GO R812T Neutral 3 0.329 PhD-SNP: F[R]=71% F[T]=18% Nali=16 R812T Neutral 8 0.079 PANTHER: F[R]=15% F[T]=24% R812T Neutral 9 0.053 SNPs&GO V815I Neutral 8 0.122 PhD-SNP: F[V]=69% F[I]=0% Nali=15 V815I Neutral 7 0.168 PANTHER: F[V]=52% F[I]=12% V815I Neutral 9 0.065 SNPs&GO S816F Neutral 5 0.240 PhD-SNP: F[S]=69% F[F]=0% Nali=15 S816F Disease 3 0.630 PANTHER: F[S]=53% F[F]=1% S816F Neutral 4 0.312 SNPs&GO R820K Neutral 3 0.337 PhD-SNP: F[R]=100% F[K]=0% Nali=16 R820K Neutral 5 0.239 PANTHER: F[R]=58% F[K]=8% R820K Neutral 6 0.185 SNPs&GO R820T Disease 2 0.614 PhD-SNP: F[R]=100% F[T]=0% Nali=16 R820T Neutral 0 0.490 PANTHER: F[R]=58% F[T]=2% R820T Disease 1 0.548 SNPs&GO A821V Neutral 0 0.480 PhD-SNP: F[A]=59% F[V]=0% Nali=16 A821V Neutral 3 0.372 PANTHER: F[A]=55% F[V]=3% A821V Neutral 4 0.308 SNPs&GO P822S Disease 1 0.546 PhD-SNP: F[P]=59% F[S]=0% Nali=16 P822S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P822S Neutral 0 0.492 SNPs&GO P824A Neutral 1 0.465 PhD-SNP: F[P]=100% F[A]=0% Nali=16 P824A Neutral 1 0.435 PANTHER: F[P]=70% F[A]=3% P824A Neutral 4 0.324 SNPs&GO P824R Disease 4 0.702 PhD-SNP: F[P]=100% F[R]=0% Nali=16 P824R Disease 2 0.622 PANTHER: F[P]=70% F[R]=1% P824R Disease 2 0.599 SNPs&GO P824S Disease 3 0.672 PhD-SNP: F[P]=100% F[S]=0% Nali=16 P824S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P824S Disease 0 0.513 SNPs&GO T826I Neutral 7 0.130 PhD-SNP: F[T]=29% F[I]=12% Nali=16 T826I Neutral 2 0.418 PANTHER: F[T]=51% F[I]=2% T826I Neutral 7 0.145 SNPs&GO T827I Disease 0 0.517 PhD-SNP: F[T]=94% F[I]=0% Nali=16 T827I Neutral 6 0.205 PANTHER: F[T]=26% F[I]=4% T827I Neutral 8 0.111 SNPs&GO G829E Disease 2 0.617 PhD-SNP: F[G]=100% F[E]=0% Nali=16 G829E Disease 1 0.571 PANTHER: F[G]=71% F[E]=2% G829E Disease 3 0.646 SNPs&GO I831L Disease 0 0.521 PhD-SNP: F[I]=100% F[L]=0% Nali=16 I831L Neutral 7 0.171 PANTHER: F[I]=49% F[L]=11% I831L Neutral 7 0.174 SNPs&GO I831V Neutral 3 0.370 PhD-SNP: F[I]=100% F[V]=0% Nali=16 I831V Neutral 7 0.141 PANTHER: F[I]=49% F[V]=14% I831V Neutral 8 0.078 SNPs&GO S832R Disease 3 0.658 PhD-SNP: F[S]=59% F[R]=0% Nali=16 S832R Neutral 0 0.483 PANTHER: F[S]=53% F[R]=2% S832R Disease 1 0.550 SNPs&GO V833I Neutral 9 0.050 PhD-SNP: F[V]=29% F[I]=29% Nali=16 V833I Neutral 9 0.066 PANTHER: F[V]=28% F[I]=37% V833I Neutral 10 0.010 SNPs&GO T835P Disease 1 0.530 PhD-SNP: F[T]=47% F[P]=12% Nali=16 T835P Disease 1 0.533 PANTHER: F[T]=51% F[P]=1% T835P Disease 2 0.591 SNPs&GO A836T Disease 3 0.661 PhD-SNP: F[A]=59% F[T]=0% Nali=16 A836T Neutral 7 0.146 PANTHER: F[A]=21% F[T]=6% A836T Neutral 5 0.234 SNPs&GO A836V Disease 4 0.715 PhD-SNP: F[A]=59% F[V]=0% Nali=16 A836V Neutral 6 0.176 PANTHER: F[A]=21% F[V]=4% A836V Neutral 5 0.233 SNPs&GO T840K Disease 2 0.623 PhD-SNP: F[T]=13% F[K]=0% Nali=15 T840K Neutral 6 0.205 PANTHER: F[T]=17% F[K]=3% T840K Neutral 4 0.287 SNPs&GO T840M Neutral 2 0.405 PhD-SNP: F[T]=13% F[M]=0% Nali=15 T840M Neutral 3 0.343 PANTHER: F[T]=17% F[M]=1% T840M Neutral 6 0.181 SNPs&GO T840R Disease 4 0.677 PhD-SNP: F[T]=13% F[R]=0% Nali=15 T840R Neutral 5 0.247 PANTHER: F[T]=17% F[R]=2% T840R Neutral 2 0.409 SNPs&GO D841N Disease 1 0.562 PhD-SNP: F[D]=56% F[N]=0% Nali=15 D841N Neutral 2 0.383 PANTHER: F[D]=60% F[N]=3% D841N Neutral 1 0.445 SNPs&GO M842I Disease 1 0.569 PhD-SNP: F[M]=60% F[I]=0% Nali=14 M842I Neutral 6 0.223 PANTHER: F[M]=44% F[I]=7% M842I Neutral 1 0.455 SNPs&GO M842T Disease 4 0.679 PhD-SNP: F[M]=60% F[T]=0% Nali=14 M842T Neutral 2 0.409 PANTHER: F[M]=44% F[T]=2% M842T Disease 5 0.741 SNPs&GO G843D Disease 1 0.549 PhD-SNP: F[G]=67% F[D]=13% Nali=14 G843D Disease 2 0.580 PANTHER: F[G]=71% F[D]=1% G843D Disease 3 0.668 SNPs&GO G846E Disease 4 0.708 PhD-SNP: F[G]=67% F[E]=7% Nali=14 G846E Disease 1 0.571 PANTHER: F[G]=71% F[E]=2% G846E Disease 6 0.817 SNPs&GO G847E Disease 6 0.776 PhD-SNP: F[G]=73% F[E]=7% Nali=14 G847E Disease 1 0.571 PANTHER: F[G]=71% F[E]=2% G847E Disease 7 0.840 SNPs&GO G847R Disease 7 0.874 PhD-SNP: F[G]=73% F[R]=0% Nali=14 G847R Disease 3 0.657 PANTHER: F[G]=71% F[R]=1% G847R Disease 8 0.886 SNPs&GO G847V Disease 8 0.877 PhD-SNP: F[G]=73% F[V]=0% Nali=14 G847V Disease 3 0.626 PANTHER: F[G]=71% F[V]=1% G847V Disease 8 0.878 SNPs&GO G848V Disease 7 0.836 PhD-SNP: F[G]=80% F[V]=7% Nali=14 G848V Disease 3 0.626 PANTHER: F[G]=71% F[V]=1% G848V Disease 7 0.855 SNPs&GO V849G Disease 3 0.665 PhD-SNP: F[V]=56% F[G]=0% Nali=15 V849G Disease 1 0.542 PANTHER: F[V]=52% F[G]=1% V849G Disease 2 0.595 SNPs&GO V849L Neutral 1 0.450 PhD-SNP: F[V]=56% F[L]=6% Nali=15 V849L Neutral 6 0.221 PANTHER: F[V]=52% F[L]=8% V849L Neutral 2 0.394 SNPs&GO G850A Disease 5 0.770 PhD-SNP: F[G]=75% F[A]=0% Nali=15 G850A Neutral 2 0.412 PANTHER: F[G]=71% F[A]=4% G850A Disease 5 0.774 SNPs&GO P851S Neutral 9 0.067 PhD-SNP: F[P]=19% F[S]=44% Nali=15 P851S Neutral 8 0.111 PANTHER: F[P]=13% F[S]=33% P851S Neutral 10 0.017 SNPs&GO P851T Neutral 5 0.227 PhD-SNP: F[P]=19% F[T]=0% Nali=15 P851T Neutral 8 0.112 PANTHER: F[P]=13% F[T]=5% P851T Neutral 9 0.050 SNPs&GO K852N Neutral 2 0.399 PhD-SNP: F[K]=13% F[N]=0% Nali=15 K852N Neutral 7 0.140 PANTHER: F[K]=17% F[N]=5% K852N Neutral 8 0.113 SNPs&GO G853A Neutral 2 0.393 PhD-SNP: F[G]=19% F[A]=0% Nali=15 G853A Neutral 8 0.088 PANTHER: F[G]=13% F[A]=7% G853A Neutral 8 0.119 SNPs&GO G853E Neutral 2 0.383 PhD-SNP: F[G]=19% F[E]=13% Nali=15 G853E Neutral 6 0.190 PANTHER: F[G]=13% F[E]=2% G853E Neutral 6 0.194 SNPs&GO G853R Neutral 3 0.357 PhD-SNP: F[G]=19% F[R]=13% Nali=15 G853R Neutral 6 0.222 PANTHER: F[G]=13% F[R]=2% G853R Neutral 6 0.183 SNPs&GO G853W Disease 2 0.592 PhD-SNP: F[G]=19% F[W]=0% Nali=15 G853W Disease 1 0.561 PANTHER: F[G]=13% F[W]=0% G853W Neutral 3 0.355 SNPs&GO G854A Neutral 0 0.490 PhD-SNP: F[G]=56% F[A]=6% Nali=15 G854A Neutral 2 0.412 PANTHER: F[G]=71% F[A]=4% G854A Disease 1 0.545 SNPs&GO G854E Disease 0 0.510 PhD-SNP: F[G]=56% F[E]=13% Nali=15 G854E Disease 1 0.571 PANTHER: F[G]=71% F[E]=2% G854E Disease 3 0.642 SNPs&GO G854V Disease 5 0.742 PhD-SNP: F[G]=56% F[V]=0% Nali=15 G854V Disease 3 0.626 PANTHER: F[G]=71% F[V]=1% G854V Disease 5 0.741 SNPs&GO V855G Neutral 8 0.091 PhD-SNP: F[V]=24% F[G]=24% Nali=16 V855G Neutral 6 0.176 PANTHER: F[V]=14% F[G]=3% V855G Neutral 9 0.035 SNPs&GO L857P Disease 4 0.719 PhD-SNP: F[L]=59% F[P]=0% Nali=16 L857P Disease 4 0.720 PANTHER: F[L]=59% F[P]=0% L857P Disease 4 0.687 SNPs&GO L857V Neutral 2 0.406 PhD-SNP: F[L]=59% F[V]=0% Nali=16 L857V Neutral 4 0.277 PANTHER: F[L]=59% F[V]=6% L857V Neutral 6 0.198 SNPs&GO C858W Disease 4 0.700 PhD-SNP: F[C]=50% F[W]=0% Nali=15 C858W Neutral 2 0.396 PANTHER: F[C]=18% F[W]=1% C858W Neutral 3 0.350 SNPs&GO C858Y Neutral 0 0.491 PhD-SNP: F[C]=50% F[Y]=13% Nali=15 C858Y Neutral 9 0.058 PANTHER: F[C]=18% F[Y]=21% C858Y Neutral 9 0.062 SNPs&GO P859R Neutral 1 0.474 PhD-SNP: F[P]=69% F[R]=0% Nali=15 P859R Disease 2 0.622 PANTHER: F[P]=70% F[R]=1% P859R Disease 1 0.543 SNPs&GO P860T Neutral 2 0.377 PhD-SNP: F[P]=75% F[T]=0% Nali=15 P860T Disease 1 0.541 PANTHER: F[P]=70% F[T]=2% P860T Neutral 2 0.380 SNPs&GO R861L Disease 3 0.635 PhD-SNP: F[R]=69% F[L]=0% Nali=15 R861L Neutral 0 0.493 PANTHER: F[R]=58% F[L]=2% R861L Disease 1 0.543 SNPs&GO R861Q Disease 1 0.527 PhD-SNP: F[R]=69% F[Q]=0% Nali=15 R861Q Neutral 2 0.413 PANTHER: F[R]=58% F[Q]=3% R861Q Neutral 2 0.379 SNPs&GO R861W Disease 1 0.555 PhD-SNP: F[R]=69% F[W]=0% Nali=15 R861W Disease 7 0.841 PANTHER: F[R]=58% F[W]=0% R861W Disease 1 0.533 SNPs&GO L864H Neutral 5 0.240 PhD-SNP: F[L]=31% F[H]=6% Nali=15 L864H Neutral 3 0.356 PANTHER: F[L]=18% F[H]=1% L864H Neutral 8 0.087 SNPs&GO L864I Neutral 9 0.068 PhD-SNP: F[L]=31% F[I]=6% Nali=15 L864I Neutral 7 0.150 PANTHER: F[L]=18% F[I]=5% L864I Neutral 10 0.014 SNPs&GO T865I Neutral 4 0.318 PhD-SNP: F[T]=88% F[I]=0% Nali=15 T865I Neutral 2 0.418 PANTHER: F[T]=51% F[I]=2% T865I Neutral 7 0.159 SNPs&GO T865P Neutral 2 0.407 PhD-SNP: F[T]=88% F[P]=0% Nali=15 T865P Disease 1 0.533 PANTHER: F[T]=51% F[P]=1% T865P Neutral 5 0.252 SNPs&GO P866L Neutral 1 0.430 PhD-SNP: F[P]=81% F[L]=0% Nali=15 P866L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P866L Neutral 1 0.447 SNPs&GO P866S Neutral 3 0.325 PhD-SNP: F[P]=81% F[S]=6% Nali=15 P866S Neutral 0 0.476 PANTHER: F[P]=70% F[S]=3% P866S Neutral 3 0.364 SNPs&GO T867I Neutral 3 0.343 PhD-SNP: F[T]=82% F[I]=0% Nali=16 T867I Neutral 2 0.418 PANTHER: F[T]=51% F[I]=2% T867I Neutral 6 0.189 SNPs&GO T867N Neutral 2 0.420 PhD-SNP: F[T]=82% F[N]=0% Nali=16 T867N Neutral 1 0.463 PANTHER: F[T]=51% F[N]=2% T867N Neutral 4 0.289 SNPs&GO T867P Neutral 1 0.451 PhD-SNP: F[T]=82% F[P]=0% Nali=16 T867P Disease 1 0.533 PANTHER: F[T]=51% F[P]=1% T867P Neutral 4 0.309 SNPs&GO P868A Neutral 5 0.253 PhD-SNP: F[P]=75% F[A]=0% Nali=15 P868A Neutral 1 0.435 PANTHER: F[P]=70% F[A]=3% P868A Neutral 4 0.285 SNPs&GO P868R Neutral 1 0.437 PhD-SNP: F[P]=75% F[R]=0% Nali=15 P868R Disease 2 0.622 PANTHER: F[P]=70% F[R]=1% P868R Disease 1 0.528 SNPs&GO E870K Disease 2 0.590 PhD-SNP: F[E]=72% F[K]=0% Nali=17 E870K Neutral 3 0.351 PANTHER: F[E]=55% F[K]=4% E870K Neutral 1 0.466 SNPs&GO G871D Disease 5 0.737 PhD-SNP: F[G]=100% F[D]=0% Nali=17 G871D Disease 2 0.580 PANTHER: F[G]=71% F[D]=1% G871D Disease 4 0.712 SNPs&GO S872C Disease 0 0.524 PhD-SNP: F[S]=100% F[C]=0% Nali=17 S872C Disease 2 0.623 PANTHER: F[S]=53% F[C]=1% S872C Neutral 3 0.361 SNPs&GO S872Y Disease 2 0.608 PhD-SNP: F[S]=100% F[Y]=0% Nali=17 S872Y Disease 3 0.649 PANTHER: F[S]=53% F[Y]=1% S872Y Neutral 0 0.481 SNPs&GO N875S Neutral 0 0.477 PhD-SNP: F[N]=100% F[S]=0% Nali=17 N875S Neutral 3 0.343 PANTHER: F[N]=53% F[S]=4% N875S Neutral 2 0.399 SNPs&GO N875T Disease 1 0.534 PhD-SNP: F[N]=100% F[T]=0% Nali=17 N875T Neutral 2 0.414 PANTHER: F[N]=53% F[T]=3% N875T Neutral 0 0.490 SNPs&GO N875Y Disease 1 0.571 PhD-SNP: F[N]=100% F[Y]=0% Nali=17 N875Y Disease 2 0.620 PANTHER: F[N]=53% F[Y]=1% N875Y Disease 1 0.528 SNPs&GO G878C Disease 5 0.752 PhD-SNP: F[G]=100% F[C]=0% Nali=17 G878C Unclassified NA NA PANTHER: F[G]=NA F[C]=NA G878C Neutral 4 0.324 SNPs&GO S879L Disease 2 0.597 PhD-SNP: F[S]=100% F[L]=0% Nali=17 S879L Neutral 1 0.475 PANTHER: F[S]=53% F[L]=2% S879L Neutral 1 0.455 SNPs&GO A880G Disease 1 0.553 PhD-SNP: F[A]=61% F[G]=0% Nali=17 A880G Neutral 3 0.368 PANTHER: F[A]=55% F[G]=3% A880G Neutral 2 0.381 SNPs&GO N884Y Disease 4 0.716 PhD-SNP: F[N]=94% F[Y]=0% Nali=17 N884Y Disease 2 0.620 PANTHER: F[N]=53% F[Y]=1% N884Y Disease 3 0.646 SNPs&GO A886T Neutral 8 0.094 PhD-SNP: F[A]=22% F[T]=22% Nali=17 A886T Neutral 7 0.157 PANTHER: F[A]=20% F[T]=5% A886T Neutral 9 0.070 SNPs&GO S887G Neutral 5 0.271 PhD-SNP: F[S]=100% F[G]=0% Nali=17 S887G Neutral 3 0.347 PANTHER: F[S]=53% F[G]=4% S887G Neutral 8 0.111 SNPs&GO S887N Neutral 3 0.327 PhD-SNP: F[S]=100% F[N]=0% Nali=17 S887N Neutral 1 0.434 PANTHER: F[S]=53% F[N]=2% S887N Neutral 6 0.191 SNPs&GO S887R Neutral 3 0.356 PhD-SNP: F[S]=100% F[R]=0% Nali=17 S887R Neutral 0 0.483 PANTHER: F[S]=53% F[R]=2% S887R Neutral 5 0.263 SNPs&GO A888D Disease 4 0.702 PhD-SNP: F[A]=83% F[D]=0% Nali=17 A888D Disease 0 0.515 PANTHER: F[A]=55% F[D]=2% A888D Disease 2 0.591 SNPs&GO A888T Neutral 7 0.164 PhD-SNP: F[A]=83% F[T]=17% Nali=17 A888T Neutral 3 0.338 PANTHER: F[A]=55% F[T]=4% A888T Neutral 6 0.201 SNPs&GO A890D Disease 3 0.656 PhD-SNP: F[A]=61% F[D]=0% Nali=17 A890D Disease 0 0.515 PANTHER: F[A]=55% F[D]=2% A890D Disease 2 0.612 SNPs&GO A890P Disease 1 0.570 PhD-SNP: F[A]=61% F[P]=0% Nali=17 A890P Disease 1 0.539 PANTHER: F[A]=55% F[P]=1% A890P Disease 1 0.542 SNPs&GO S891R Neutral 0 0.492 PhD-SNP: F[S]=100% F[R]=0% Nali=17 S891R Neutral 0 0.483 PANTHER: F[S]=53% F[R]=2% S891R Neutral 3 0.335 SNPs&GO V893A Neutral 5 0.235 PhD-SNP: F[V]=78% F[A]=11% Nali=17 V893A Neutral 3 0.331 PANTHER: F[V]=52% F[A]=4% V893A Neutral 6 0.204 SNPs&GO S894R Disease 0 0.522 PhD-SNP: F[S]=100% F[R]=0% Nali=17 S894R Neutral 0 0.483 PANTHER: F[S]=53% F[R]=2% S894R Neutral 3 0.351 SNPs&GO S894T Neutral 5 0.272 PhD-SNP: F[S]=100% F[T]=0% Nali=17 S894T Neutral 4 0.322 PANTHER: F[S]=53% F[T]=4% S894T Neutral 7 0.148 SNPs&GO S895F Disease 3 0.635 PhD-SNP: F[S]=100% F[F]=0% Nali=17 S895F Disease 3 0.630 PANTHER: F[S]=53% F[F]=1% S895F Neutral 0 0.485 SNPs&GO S895P Disease 0 0.505 PhD-SNP: F[S]=100% F[P]=0% Nali=17 S895P Disease 0 0.515 PANTHER: F[S]=53% F[P]=1% S895P Neutral 2 0.418 SNPs&GO S896F Disease 3 0.633 PhD-SNP: F[S]=94% F[F]=0% Nali=17 S896F Disease 3 0.630 PANTHER: F[S]=53% F[F]=1% S896F Neutral 0 0.488 SNPs&GO D897N Disease 3 0.653 PhD-SNP: F[D]=100% F[N]=0% Nali=17 D897N Neutral 2 0.383 PANTHER: F[D]=60% F[N]=3% D897N Neutral 1 0.437 SNPs&GO G898S Disease 2 0.613 PhD-SNP: F[G]=89% F[S]=0% Nali=17 G898S Neutral 1 0.452 PANTHER: F[G]=71% F[S]=3% G898S Disease 1 0.547 SNPs&GO G898V Disease 3 0.658 PhD-SNP: F[G]=89% F[V]=0% Nali=17 G898V Disease 3 0.626 PANTHER: F[G]=71% F[V]=1% G898V Disease 2 0.607 SNPs&GO S899F Disease 5 0.742 PhD-SNP: F[S]=100% F[F]=0% Nali=17 S899F Disease 3 0.630 PANTHER: F[S]=53% F[F]=1% S899F Disease 2 0.580 SNPs&GO S899P Disease 2 0.618 PhD-SNP: F[S]=100% F[P]=0% Nali=17 S899P Disease 0 0.515 PANTHER: F[S]=53% F[P]=1% S899P Disease 0 0.519 SNPs&GO S899Y Disease 4 0.688 PhD-SNP: F[S]=100% F[Y]=0% Nali=17 S899Y Disease 3 0.649 PANTHER: F[S]=53% F[Y]=1% S899Y Disease 1 0.540 SNPs&GO F900L Disease 2 0.582 PhD-SNP: F[F]=94% F[L]=0% Nali=17 F900L Neutral 5 0.250 PANTHER: F[F]=57% F[L]=7% F900L Neutral 4 0.318 SNPs&GO A902S Disease 3 0.651 PhD-SNP: F[A]=61% F[S]=0% Nali=17 A902S Neutral 4 0.280 PANTHER: F[A]=55% F[S]=6% A902S Neutral 1 0.442 SNPs&GO A902T Disease 1 0.545 PhD-SNP: F[A]=61% F[T]=0% Nali=17 A902T Neutral 3 0.338 PANTHER: F[A]=55% F[T]=4% A902T Neutral 1 0.430 SNPs&GO D903V Disease 6 0.816 PhD-SNP: F[D]=100% F[V]=0% Nali=17 D903V Disease 2 0.622 PANTHER: F[D]=60% F[V]=1% D903V Disease 4 0.698 SNPs&GO A904V Disease 5 0.764 PhD-SNP: F[A]=89% F[V]=0% Nali=17 A904V Neutral 6 0.221 PANTHER: F[A]=29% F[V]=4% A904V Neutral 3 0.328 SNPs&GO H905N Neutral 2 0.391 PhD-SNP: F[H]=56% F[N]=28% Nali=17 H905N Neutral 0 0.497 PANTHER: F[H]=57% F[N]=2% H905N Disease 0 0.515 SNPs&GO H905P Disease 8 0.901 PhD-SNP: F[H]=56% F[P]=0% Nali=17 H905P Disease 3 0.632 PANTHER: F[H]=57% F[P]=1% H905P Disease 8 0.890 SNPs&GO A907V Disease 6 0.824 PhD-SNP: F[A]=100% F[V]=0% Nali=17 A907V Neutral 3 0.372 PANTHER: F[A]=55% F[V]=3% A907V Disease 2 0.603 SNPs&GO R908G Disease 7 0.830 PhD-SNP: F[R]=83% F[G]=0% Nali=17 R908G Disease 0 0.521 PANTHER: F[R]=58% F[G]=2% R908G Disease 3 0.652 SNPs&GO R908L Disease 8 0.886 PhD-SNP: F[R]=83% F[L]=0% Nali=17 R908L Neutral 0 0.493 PANTHER: F[R]=58% F[L]=2% R908L Disease 6 0.787 SNPs&GO R908Q Disease 6 0.781 PhD-SNP: F[R]=83% F[Q]=0% Nali=17 R908Q Neutral 2 0.413 PANTHER: F[R]=58% F[Q]=3% R908Q Disease 1 0.557 SNPs&GO R908W Disease 7 0.849 PhD-SNP: F[R]=83% F[W]=0% Nali=17 R908W Disease 7 0.841 PANTHER: F[R]=58% F[W]=0% R908W Disease 5 0.745 SNPs&GO A909T Disease 6 0.797 PhD-SNP: F[A]=88% F[T]=0% Nali=16 A909T Neutral 3 0.338 PANTHER: F[A]=55% F[T]=4% A909T Disease 3 0.657 SNPs&GO A909V Disease 4 0.677 PhD-SNP: F[A]=88% F[V]=12% Nali=16 A909V Neutral 3 0.372 PANTHER: F[A]=55% F[V]=3% A909V Disease 0 0.524 SNPs&GO V912A Disease 3 0.657 PhD-SNP: F[V]=82% F[A]=0% Nali=16 V912A Neutral 3 0.331 PANTHER: F[V]=52% F[A]=4% V912A Neutral 1 0.434 SNPs&GO V912E Disease 7 0.870 PhD-SNP: F[V]=82% F[E]=0% Nali=16 V912E Disease 2 0.596 PANTHER: F[V]=52% F[E]=1% V912E Disease 6 0.824 SNPs&GO V912L Disease 1 0.565 PhD-SNP: F[V]=82% F[L]=12% Nali=16 V912L Neutral 6 0.221 PANTHER: F[V]=52% F[L]=8% V912L Neutral 2 0.424 SNPs&GO V914G Disease 7 0.828 PhD-SNP: F[V]=71% F[G]=0% Nali=16 V914G Disease 1 0.542 PANTHER: F[V]=52% F[G]=1% V914G Disease 3 0.655 SNPs&GO V914M Disease 4 0.683 PhD-SNP: F[V]=71% F[M]=0% Nali=16 V914M Neutral 1 0.473 PANTHER: F[V]=52% F[M]=2% V914M Neutral 2 0.422 SNPs&GO D915G Disease 7 0.867 PhD-SNP: F[D]=88% F[G]=0% Nali=16 D915G Neutral 1 0.452 PANTHER: F[D]=60% F[G]=2% D915G Disease 3 0.652 SNPs&GO G918D Disease 6 0.822 PhD-SNP: F[G]=59% F[D]=0% Nali=16 G918D Disease 2 0.580 PANTHER: F[G]=71% F[D]=1% G918D Disease 6 0.791 SNPs&GO G918R Disease 6 0.805 PhD-SNP: F[G]=59% F[R]=0% Nali=16 G918R Disease 3 0.657 PANTHER: F[G]=71% F[R]=1% G918R Disease 6 0.775 SNPs&GO G918S Neutral 1 0.460 PhD-SNP: F[G]=59% F[S]=12% Nali=16 G918S Neutral 1 0.452 PANTHER: F[G]=71% F[S]=3% G918S Neutral 2 0.417 SNPs&GO F919L Disease 1 0.530 PhD-SNP: F[F]=71% F[L]=12% Nali=16 F919L Neutral 9 0.070 PANTHER: F[F]=24% F[L]=34% F919L Neutral 9 0.048 SNPs&GO G920S Neutral 3 0.335 PhD-SNP: F[G]=59% F[S]=18% Nali=16 G920S Neutral 8 0.097 PANTHER: F[G]=16% F[S]=35% G920S Neutral 9 0.041 SNPs&GO L921V Disease 4 0.709 PhD-SNP: F[L]=88% F[V]=0% Nali=16 L921V Neutral 4 0.277 PANTHER: F[L]=59% F[V]=6% L921V Neutral 2 0.391 SNPs&GO P923L Disease 5 0.730 PhD-SNP: F[P]=64% F[L]=0% Nali=13 P923L Disease 2 0.600 PANTHER: F[P]=70% F[L]=1% P923L Disease 3 0.636 SNPs&GO P923T Disease 2 0.621 PhD-SNP: F[P]=64% F[T]=0% Nali=13 P923T Disease 1 0.541 PANTHER: F[P]=70% F[T]=2% P923T Neutral 0 0.477 SNPs&GO R924K Disease 1 0.532 PhD-SNP: F[R]=64% F[K]=7% Nali=13 R924K Neutral 5 0.239 PANTHER: F[R]=58% F[K]=8% R924K Neutral 4 0.319 SNPs&GO R924M Disease 3 0.673 PhD-SNP: F[R]=64% F[M]=0% Nali=13 R924M Disease 4 0.705 PANTHER: F[R]=58% F[M]=0% R924M Disease 1 0.563 SNPs&GO R924S Disease 5 0.748 PhD-SNP: F[R]=64% F[S]=0% Nali=13 R924S Neutral 1 0.452 PANTHER: F[R]=58% F[S]=2% R924S Disease 3 0.633 SNPs&GO E925G Disease 6 0.797 PhD-SNP: F[E]=67% F[G]=0% Nali=14 E925G Neutral 1 0.438 PANTHER: F[E]=55% F[G]=2% E925G Disease 2 0.593 SNPs&GO A926E Disease 6 0.787 PhD-SNP: F[A]=62% F[E]=0% Nali=12 A926E Neutral 0 0.479 PANTHER: F[A]=55% F[E]=2% A926E Disease 4 0.678 SNPs&GO D927A Disease 1 0.532 PhD-SNP: F[D]=85% F[A]=15% Nali=12 D927A Neutral 1 0.432 PANTHER: F[D]=60% F[A]=3% D927A Neutral 0 0.480 SNPs&GO C928S Disease 7 0.826 PhD-SNP: F[C]=77% F[S]=0% Nali=12 C928S Neutral 1 0.428 PANTHER: F[C]=65% F[S]=3% C928S Disease 3 0.658 SNPs&GO V929I Neutral 4 0.300 PhD-SNP: F[V]=77% F[I]=0% Nali=12 V929I Neutral 7 0.168 PANTHER: F[V]=52% F[I]=12% V929I Neutral 8 0.117 SNPs&GO F930L Neutral 1 0.474 PhD-SNP: F[F]=77% F[L]=0% Nali=12 F930L Neutral 5 0.250 PANTHER: F[F]=57% F[L]=7% F930L Neutral 5 0.245 SNPs&GO I931T Neutral 9 0.050 PhD-SNP: F[I]=23% F[T]=62% Nali=12 I931T Neutral 9 0.066 PANTHER: F[I]=18% F[T]=23% I931T Neutral 10 0.015 SNPs&GO D932N Disease 2 0.586 PhD-SNP: F[D]=93% F[N]=0% Nali=14 D932N Neutral 4 0.276 PANTHER: F[D]=53% F[N]=4% D932N Neutral 3 0.331 SNPs&GO A933V Neutral 1 0.428 PhD-SNP: F[A]=60% F[V]=0% Nali=14 A933V Neutral 5 0.261 PANTHER: F[A]=48% F[V]=4% A933V Neutral 7 0.169 SNPs&GO S934P Disease 1 0.566 PhD-SNP: F[S]=100% F[P]=0% Nali=14 S934P Neutral 2 0.399 PANTHER: F[S]=45% F[P]=2% S934P Neutral 2 0.413 SNPs&GO P936L Disease 4 0.701 PhD-SNP: F[P]=87% F[L]=0% Nali=14 P936L Neutral 1 0.448 PANTHER: F[P]=61% F[L]=2% P936L Neutral 0 0.495 SNPs&GO S938F Disease 3 0.674 PhD-SNP: F[S]=100% F[F]=0% Nali=14 S938F Disease 0 0.504 PANTHER: F[S]=45% F[F]=1% S938F Neutral 1 0.472 SNPs&GO S938T Neutral 1 0.434 PhD-SNP: F[S]=100% F[T]=0% Nali=14 S938T Neutral 5 0.228 PANTHER: F[S]=45% F[T]=5% S938T Neutral 6 0.201 SNPs&GO P939L Disease 3 0.674 PhD-SNP: F[P]=100% F[L]=0% Nali=14 P939L Neutral 1 0.448 PANTHER: F[P]=61% F[L]=2% P939L Disease 1 0.525 SNPs&GO P939Q Disease 4 0.712 PhD-SNP: F[P]=100% F[Q]=0% Nali=14 P939Q Disease 0 0.512 PANTHER: F[P]=61% F[Q]=1% P939Q Disease 1 0.552 SNPs&GO P939S Disease 3 0.666 PhD-SNP: F[P]=100% F[S]=0% Nali=14 P939S Neutral 3 0.337 PANTHER: F[P]=61% F[S]=3% P939S Neutral 1 0.468 SNPs&GO R940G Disease 0 0.504 PhD-SNP: F[R]=60% F[G]=0% Nali=14 R940G Neutral 2 0.396 PANTHER: F[R]=51% F[G]=2% R940G Neutral 3 0.326 SNPs&GO R940L Neutral 4 0.291 PhD-SNP: F[R]=60% F[L]=33% Nali=14 R940L Neutral 3 0.361 PANTHER: F[R]=51% F[L]=2% R940L Neutral 3 0.347 SNPs&GO R940Q Neutral 3 0.374 PhD-SNP: F[R]=60% F[Q]=7% Nali=14 R940Q Neutral 4 0.298 PANTHER: F[R]=51% F[Q]=3% R940Q Neutral 5 0.238 SNPs&GO R940W Disease 2 0.586 PhD-SNP: F[R]=60% F[W]=0% Nali=14 R940W Disease 5 0.762 PANTHER: F[R]=51% F[W]=0% R940W Disease 1 0.532 SNPs&GO D941A Neutral 1 0.434 PhD-SNP: F[D]=67% F[A]=0% Nali=14 D941A Neutral 7 0.127 PANTHER: F[D]=21% F[A]=5% D941A Neutral 8 0.092 SNPs&GO D941V Disease 2 0.583 PhD-SNP: F[D]=67% F[V]=0% Nali=14 D941V Neutral 5 0.250 PANTHER: F[D]=21% F[V]=2% D941V Neutral 7 0.153 SNPs&GO I943F Neutral 5 0.260 PhD-SNP: F[I]=33% F[F]=7% Nali=14 I943F Neutral 7 0.172 PANTHER: F[I]=23% F[F]=3% I943F Neutral 8 0.087 SNPs&GO I943T Neutral 4 0.298 PhD-SNP: F[I]=33% F[T]=0% Nali=14 I943T Neutral 6 0.221 PANTHER: F[I]=23% F[T]=2% I943T Neutral 8 0.117 SNPs&GO I943V Neutral 8 0.088 PhD-SNP: F[I]=33% F[V]=7% Nali=14 I943V Neutral 9 0.067 PANTHER: F[I]=23% F[V]=13% I943V Neutral 10 0.015 SNPs&GO T946A Neutral 2 0.379 PhD-SNP: F[T]=67% F[A]=0% Nali=14 T946A Neutral 7 0.167 PANTHER: F[T]=43% F[A]=7% T946A Neutral 7 0.168 SNPs&GO T946I Disease 1 0.573 PhD-SNP: F[T]=67% F[I]=0% Nali=14 T946I Neutral 4 0.292 PANTHER: F[T]=43% F[I]=3% T946I Neutral 5 0.252 SNPs&GO T946N Disease 2 0.594 PhD-SNP: F[T]=67% F[N]=0% Nali=14 T946N Neutral 3 0.339 PANTHER: F[T]=43% F[N]=2% T946N Neutral 3 0.368 SNPs&GO T946P Disease 0 0.508 PhD-SNP: F[T]=67% F[P]=7% Nali=14 T946P Neutral 2 0.412 PANTHER: F[T]=43% F[P]=1% T946P Neutral 4 0.308 SNPs&GO P947A Neutral 6 0.191 PhD-SNP: F[P]=27% F[A]=0% Nali=14 P947A Neutral 8 0.079 PANTHER: F[P]=12% F[A]=5% P947A Neutral 9 0.033 SNPs&GO P947R Neutral 5 0.263 PhD-SNP: F[P]=27% F[R]=13% Nali=14 P947R Neutral 9 0.072 PANTHER: F[P]=12% F[R]=23% P947R Neutral 9 0.030 SNPs&GO N948K Neutral 4 0.279 PhD-SNP: F[N]=20% F[K]=0% Nali=14 N948K Neutral 8 0.096 PANTHER: F[N]=15% F[K]=5% N948K Neutral 9 0.073 SNPs&GO N948T Neutral 9 0.042 PhD-SNP: F[N]=20% F[T]=33% Nali=14 N948T Neutral 8 0.101 PANTHER: F[N]=15% F[T]=5% N948T Neutral 10 0.012 SNPs&GO L949I Neutral 1 0.450 PhD-SNP: F[L]=53% F[I]=0% Nali=14 L949I Neutral 8 0.116 PANTHER: F[L]=29% F[I]=8% L949I Neutral 8 0.080 SNPs&GO L949P Disease 6 0.802 PhD-SNP: F[L]=53% F[P]=0% Nali=14 L949P Neutral 0 0.498 PANTHER: F[L]=29% F[P]=0% L949P Disease 1 0.544 SNPs&GO S950P Disease 1 0.542 PhD-SNP: F[S]=60% F[P]=13% Nali=14 S950P Neutral 2 0.399 PANTHER: F[S]=45% F[P]=2% S950P Neutral 1 0.473 SNPs&GO P952T Neutral 5 0.249 PhD-SNP: F[P]=80% F[T]=20% Nali=14 P952T Neutral 2 0.397 PANTHER: F[P]=61% F[T]=2% P952T Neutral 6 0.200 SNPs&GO E955Q Neutral 2 0.397 PhD-SNP: F[E]=67% F[Q]=0% Nali=14 E955Q Neutral 4 0.295 PANTHER: F[E]=48% F[Q]=3% E955Q Neutral 6 0.210 SNPs&GO W956R Disease 4 0.703 PhD-SNP: F[W]=100% F[R]=0% Nali=14 W956R Neutral 0 0.498 PANTHER: F[W]=59% F[R]=1% W956R Disease 0 0.522 SNPs&GO P958L Neutral 4 0.299 PhD-SNP: F[P]=36% F[L]=0% Nali=13 P958L Neutral 1 0.448 PANTHER: F[P]=61% F[L]=2% P958L Neutral 3 0.334 SNPs&GO W960C Disease 3 0.672 PhD-SNP: F[W]=100% F[C]=0% Nali=13 W960C Disease 4 0.707 PANTHER: F[W]=59% F[C]=0% W960C Disease 2 0.584 SNPs&GO W960R Disease 4 0.699 PhD-SNP: F[W]=100% F[R]=0% Nali=13 W960R Neutral 0 0.498 PANTHER: F[W]=59% F[R]=1% W960R Disease 1 0.553 SNPs&GO W960S Disease 4 0.716 PhD-SNP: F[W]=100% F[S]=0% Nali=13 W960S Neutral 0 0.479 PANTHER: F[W]=59% F[S]=1% W960S Disease 2 0.598 SNPs&GO L961W Disease 1 0.568 PhD-SNP: F[L]=64% F[W]=0% Nali=13 L961W Disease 4 0.715 PANTHER: F[L]=53% F[W]=0% L961W Neutral 1 0.460 SNPs&GO E962G Neutral 1 0.460 PhD-SNP: F[E]=86% F[G]=0% Nali=13 E962G Neutral 3 0.325 PANTHER: F[E]=48% F[G]=3% E962G Neutral 5 0.230 SNPs&GO D963N Disease 0 0.513 PhD-SNP: F[D]=64% F[N]=0% Nali=13 D963N Neutral 4 0.276 PANTHER: F[D]=53% F[N]=4% D963N Neutral 5 0.238 SNPs&GO D963V Disease 2 0.616 PhD-SNP: F[D]=64% F[V]=0% Nali=13 D963V Neutral 0 0.483 PANTHER: F[D]=53% F[V]=1% D963V Neutral 1 0.440 SNPs&GO M964R Disease 4 0.702 PhD-SNP: F[M]=57% F[R]=0% Nali=13 M964R Neutral 7 0.131 PANTHER: F[M]=12% F[R]=3% M964R Neutral 5 0.225 SNPs&GO M964T Disease 2 0.606 PhD-SNP: F[M]=57% F[T]=0% Nali=13 M964T Neutral 8 0.085 PANTHER: F[M]=12% F[T]=5% M964T Neutral 6 0.177 SNPs&GO E965G Disease 1 0.548 PhD-SNP: F[E]=100% F[G]=0% Nali=13 E965G Neutral 3 0.325 PANTHER: F[E]=48% F[G]=3% E965G Neutral 5 0.261 SNPs&GO V966A Neutral 7 0.172 PhD-SNP: F[V]=25% F[A]=17% Nali=11 V966A Neutral 6 0.199 PANTHER: F[V]=29% F[A]=4% V966A Neutral 7 0.132 SNPs&GO V966F Neutral 0 0.483 PhD-SNP: F[V]=25% F[F]=0% Nali=11 V966F Neutral 5 0.274 PANTHER: F[V]=29% F[F]=2% V966F Neutral 5 0.245 SNPs&GO V966G Neutral 1 0.470 PhD-SNP: F[V]=25% F[G]=0% Nali=11 V966G Neutral 1 0.462 PANTHER: F[V]=29% F[G]=1% V966G Neutral 2 0.392 SNPs&GO H968P Disease 0 0.520 PhD-SNP: F[H]=50% F[P]=17% Nali=11 H968P Neutral 0 0.496 PANTHER: F[H]=48% F[P]=1% H968P Disease 3 0.638 SNPs&GO R971Q Neutral 2 0.385 PhD-SNP: F[R]=67% F[Q]=8% Nali=11 R971Q Neutral 4 0.298 PANTHER: F[R]=51% F[Q]=3% R971Q Neutral 4 0.282 SNPs&GO R971W Neutral 2 0.377 PhD-SNP: F[R]=67% F[W]=17% Nali=11 R971W Disease 5 0.762 PANTHER: F[R]=51% F[W]=0% R971W Neutral 2 0.415 SNPs&GO G973R Disease 3 0.666 PhD-SNP: F[G]=82% F[R]=0% Nali=10 G973R Neutral 5 0.274 PANTHER: F[G]=49% F[R]=2% G973R Neutral 1 0.467 SNPs&GO R974S Disease 1 0.568 PhD-SNP: F[R]=91% F[S]=0% Nali=10 R974S Neutral 7 0.155 PANTHER: F[R]=38% F[S]=4% R974S Neutral 4 0.287 SNPs&GO G975E Disease 2 0.617 PhD-SNP: F[G]=91% F[E]=0% Nali=10 G975E Neutral 6 0.207 PANTHER: F[G]=49% F[E]=3% G975E Neutral 1 0.449 SNPs&GO G975R Neutral 1 0.432 PhD-SNP: F[G]=91% F[R]=9% Nali=10 G975R Neutral 5 0.274 PANTHER: F[G]=49% F[R]=2% G975R Neutral 3 0.342 SNPs&GO G975V Disease 3 0.668 PhD-SNP: F[G]=91% F[V]=0% Nali=10 G975V Neutral 5 0.247 PANTHER: F[G]=49% F[V]=2% G975V Neutral 2 0.406 SNPs&GO M976I Neutral 2 0.399 PhD-SNP: F[M]=27% F[I]=0% Nali=10 M976I Neutral 9 0.054 PANTHER: F[M]=4% F[I]=9% M976I Neutral 9 0.067 SNPs&GO M976V Neutral 1 0.427 PhD-SNP: F[M]=27% F[V]=0% Nali=10 M976V Neutral 9 0.052 PANTHER: F[M]=4% F[V]=9% M976V Neutral 9 0.052 SNPs&GO P977A Neutral 2 0.408 PhD-SNP: F[P]=100% F[A]=0% Nali=10 P977A Neutral 7 0.132 PANTHER: F[P]=44% F[A]=6% P977A Neutral 6 0.175 SNPs&GO P977H Disease 2 0.602 PhD-SNP: F[P]=100% F[H]=0% Nali=10 P977H Neutral 2 0.376 PANTHER: F[P]=44% F[H]=1% P977H Neutral 4 0.313 SNPs&GO P977L Disease 0 0.505 PhD-SNP: F[P]=100% F[L]=0% Nali=10 P977L Neutral 6 0.211 PANTHER: F[P]=44% F[L]=3% P977L Neutral 5 0.268 SNPs&GO P977T Disease 1 0.560 PhD-SNP: F[P]=100% F[T]=0% Nali=10 P977T Neutral 6 0.185 PANTHER: F[P]=44% F[T]=4% P977T Neutral 5 0.261 SNPs&GO P978L Neutral 2 0.387 PhD-SNP: F[P]=82% F[L]=0% Nali=10 P978L Neutral 6 0.211 PANTHER: F[P]=44% F[L]=3% P978L Neutral 6 0.188 SNPs&GO P980L Neutral 7 0.161 PhD-SNP: F[P]=73% F[L]=18% Nali=10 P980L Neutral 6 0.211 PANTHER: F[P]=44% F[L]=3% P980L Neutral 8 0.119 SNPs&GO P980S Neutral 3 0.333 PhD-SNP: F[P]=73% F[S]=0% Nali=10 P980S Neutral 7 0.151 PANTHER: F[P]=44% F[S]=5% P980S Neutral 7 0.129 SNPs&GO S983P Neutral 0 0.485 PhD-SNP: F[S]=73% F[P]=0% Nali=10 S983P Neutral 6 0.220 PANTHER: F[S]=34% F[P]=2% S983P Neutral 5 0.229 SNPs&GO Q984H Neutral 5 0.244 PhD-SNP: F[Q]=18% F[H]=0% Nali=10 Q984H Neutral 9 0.052 PANTHER: F[Q]=4% F[H]=2% Q984H Neutral 9 0.039 SNPs&GO Q984P Neutral 1 0.426 PhD-SNP: F[Q]=18% F[P]=9% Nali=10 Q984P Neutral 9 0.060 PANTHER: F[Q]=4% F[P]=1% Q984P Neutral 8 0.093 SNPs&GO I985F Neutral 4 0.321 PhD-SNP: F[I]=60% F[F]=0% Nali=9 I985F Neutral 9 0.057 PANTHER: F[I]=4% F[F]=1% I985F Neutral 9 0.055 SNPs&GO I985V Neutral 9 0.061 PhD-SNP: F[I]=60% F[V]=10% Nali=9 I985V Neutral 9 0.036 PANTHER: F[I]=4% F[V]=5% I985V Neutral 10 0.010 SNPs&GO S986F Neutral 1 0.444 PhD-SNP: F[S]=90% F[F]=0% Nali=9 S986F Neutral 4 0.285 PANTHER: F[S]=34% F[F]=1% S986F Neutral 7 0.165 SNPs&GO S987F Neutral 0 0.492 PhD-SNP: F[S]=80% F[F]=0% Nali=9 S987F Neutral 4 0.285 PANTHER: F[S]=34% F[F]=1% S987F Neutral 6 0.190 SNPs&GO S987P Neutral 4 0.315 PhD-SNP: F[S]=80% F[P]=10% Nali=9 S987P Neutral 6 0.220 PANTHER: F[S]=34% F[P]=2% S987P Neutral 7 0.151 SNPs&GO Q988R Neutral 5 0.253 PhD-SNP: F[Q]=90% F[R]=10% Nali=9 Q988R Neutral 8 0.097 PANTHER: F[Q]=29% F[R]=6% Q988R Neutral 8 0.086 SNPs&GO S990I Disease 3 0.628 PhD-SNP: F[S]=90% F[I]=0% Nali=9 S990I Neutral 6 0.207 PANTHER: F[S]=34% F[I]=2% S990I Neutral 6 0.196 SNPs&GO H993Q Neutral 2 0.377 PhD-SNP: F[H]=40% F[Q]=0% Nali=9 H993Q Neutral 9 0.048 PANTHER: F[H]=1% F[Q]=2% H993Q Neutral 9 0.058 SNPs&GO C994S Neutral 6 0.213 PhD-SNP: F[C]=40% F[S]=20% Nali=9 C994S Neutral 8 0.102 PANTHER: F[C]=1% F[S]=5% C994S Neutral 9 0.045 SNPs&GO R995C Disease 2 0.610 PhD-SNP: F[R]=40% F[C]=0% Nali=9 R995C Neutral 9 0.047 PANTHER: F[R]=2% F[C]=1% R995C Neutral 9 0.054 SNPs&GO R995H Neutral 2 0.386 PhD-SNP: F[R]=40% F[H]=0% Nali=9 R995H Neutral 9 0.051 PANTHER: F[R]=2% F[H]=1% R995H Neutral 9 0.049 SNPs&GO M996R Disease 2 0.577 PhD-SNP: F[M]=40% F[R]=0% Nali=9 M996R Neutral 9 0.037 PANTHER: F[M]=2% F[R]=2% M996R Neutral 8 0.120 SNPs&GO M996T Neutral 1 0.453 PhD-SNP: F[M]=40% F[T]=0% Nali=9 M996T Neutral 9 0.036 PANTHER: F[M]=2% F[T]=4% M996T Neutral 8 0.093 SNPs&GO P997H Disease 5 0.725 PhD-SNP: F[P]=100% F[H]=0% Nali=9 P997H Neutral 2 0.376 PANTHER: F[P]=44% F[H]=1% P997H Neutral 3 0.362 SNPs&GO P997L Disease 4 0.699 PhD-SNP: F[P]=100% F[L]=0% Nali=9 P997L Neutral 6 0.211 PANTHER: F[P]=44% F[L]=3% P997L Neutral 4 0.322 SNPs&GO P997T Disease 4 0.718 PhD-SNP: F[P]=100% F[T]=0% Nali=9 P997T Neutral 6 0.185 PANTHER: F[P]=44% F[T]=4% P997T Neutral 3 0.340 SNPs&GO A999T Neutral 2 0.421 PhD-SNP: F[A]=90% F[T]=10% Nali=9 A999T Unclassified NA NA PANTHER: F[A]=NA F[T]=NA A999T Neutral 7 0.130 SNPs&GO A999V Disease 2 0.615 PhD-SNP: F[A]=90% F[V]=0% Nali=9 A999V Unclassified NA NA PANTHER: F[A]=NA F[V]=NA A999V Neutral 4 0.289 SNPs&GO G1000A Neutral 5 0.262 PhD-SNP: F[G]=90% F[A]=10% Nali=9 G1000A Unclassified NA NA PANTHER: F[G]=NA F[A]=NA G1000A Neutral 8 0.112 SNPs&GO S1002C Neutral 3 0.362 PhD-SNP: F[S]=100% F[C]=0% Nali=9 S1002C Unclassified NA NA PANTHER: F[S]=NA F[C]=NA S1002C Neutral 7 0.131 SNPs&GO S1002F Disease 0 0.521 PhD-SNP: F[S]=100% F[F]=0% Nali=9 S1002F Unclassified NA NA PANTHER: F[S]=NA F[F]=NA S1002F Neutral 5 0.227 SNPs&GO P1003S Neutral 8 0.115 PhD-SNP: F[P]=75% F[S]=25% Nali=3 P1003S Unclassified NA NA PANTHER: F[P]=NA F[S]=NA P1003S Neutral 9 0.039 SNPs&GO V1004I Neutral 7 0.137 PhD-SNP: F[V]=100% F[I]=0% Nali=3 V1004I Unclassified NA NA PANTHER: F[V]=NA F[I]=NA V1004I Neutral 9 0.056 SNPs&GO D1005G Neutral 3 0.362 PhD-SNP: F[D]=75% F[G]=0% Nali=3 D1005G Unclassified NA NA PANTHER: F[D]=NA F[G]=NA D1005G Neutral 8 0.113 SNPs&GO S1007P Neutral 6 0.221 PhD-SNP: F[S]=75% F[P]=0% Nali=3 S1007P Unclassified NA NA PANTHER: F[S]=NA F[P]=NA S1007P Neutral 8 0.093 SNPs&GO Mutation: WT+POS+NEW WT: Residue in wild-type protein POS: Residue position NEW: New residue after mutation Prediction: Neutral: Neutral variation Disease: Disease associated variation RI: Reliability Index Probability: Disease probability (if >0.5 mutation is predicted Disease) Method: SVM type and data PANTHER: Output of the PANTHER algorithm PhD-SNP: SVM input is the sequence and profile at the mutated position SNPs&GO: SVM input is all the input in PhD-SNP, PANTHER and GO term features F[X]: Frequency of residue X in the sequence profile Nali: Number of aligned sequences in the mutated site ********************************************************************************************** ** ** ** Calabrese R, Capriotti E, Fariselli P, Martelli PL, Casadio R. (2009). Functional ** ** annotations improve the predictive score of human disease-related mutations in ** ** proteins. Human Mutation. 30:1237-1244. ** ** ** ** Capriotti E, Altman RB. (2011). Improving the prediction of disease-related vari- ** ** ants using protein three-dimensional structure. BMC Bioinformatics. 12 (Sup.4) S3. ** ** ** **********************************************************************************************