SNPs&GO: Predicting disease-related SNPs using GO terms
|
Mutation |
Prediction |
RI |
Probability |
|
Method |
|
A100c |
Disease |
5 |
0.215 |
|
SVM-GOS: NUMGO=229 LOG GOSSCORE=189.0 |
A100c |
Neutral |
5 |
0.215 |
|
SVM-GOS: NUMGO=229 LOG GOSSCORE=189.0 |
A100c |
Neutral |
5 |
0.215 |
|
SVM-GOS: NUMGO=229 LOG GOSSCORE=189.0 |
|
|
Mutation: WT+POS+NEW
WT: Aminoacid in Wild-Type Protein
POS: Residue Number
NEW: New Aminoacid after Mutation
Prediction:
Neutral: Neural Polymorphism
Disease: Disease-related Polymorphism
RI: Reliability Index
Probability: Disease probability (if >0.5 mutation is predicted Disease)
Method: SVM type and data
SEQPROF: SVM input is the sequence and priofile at the mutated position
SVM-GOS: SVM input is the GO score for the mutated sequence
PANTHER: HMM-based method using multiple sequence alignment
SNPs&GO: SVM input is all the input in SEQPROF and GOS
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