PDB CHAIN MUTATION EFFECT PREDICTION DPROB ____________________________________________________________ 1A02 N H446R Neutral Disease 0.524 1A02 N R446H *Neutral Neutral 0.028 1A4I B K134R *Neutral Neutral 0.157 1A4I B R134K Neutral Disease 0.924 1A4I B L162P *Neutral Disease 0.670 1A4I B P162L Neutral Disease 0.871 1A4I B H293R *Neutral Neutral 0.018 1A4I B R293H Neutral Disease 0.935 1A5E A A100L Disease Disease 0.912 1A5E A A100P Neutral Disease 0.952 1A5E A P100A *Neutral Neutral 0.022 1A5E A G101W Disease Disease 0.936 1A5E A A102E Disease Disease 0.954 1A5E A A102T Neutral Disease 0.915 1A5E A T102A *Neutral Neutral 0.001 1A5E A H107R *Neutral Neutral 0.051 1A5E A R107C Disease Disease 0.942 1A5E A R107H Neutral Disease 0.912 1A5E A D108H Disease Disease 0.947 1A5E A D108Y Disease Disease 0.960 1A5E A P114L Disease Disease 0.911 1A5E A L117M Disease Disease 0.896 1A5E A A118T Disease Disease 0.943 1A5E A E119Q Disease Disease 0.645 1A5E A E120A Disease Disease 0.837 1A5E A E120K Disease Disease 0.845 1A5E A G122R Disease Disease 0.926 1A5E A G122S Disease Disease 0.924 1A5E A H123Q Disease Disease 0.915 1A5E A C124R *Neutral Neutral 0.133 1A5E A R124C Neutral Disease 0.906 1A5E A R124H Disease Disease 0.720 1A5E A V126D Disease Disease 0.951 1A5E A A127S Disease Disease 0.927 1A5E A A132P Disease Disease 0.976 1A5E A A134V Disease Disease 0.912 1A5E A D14E Disease Disease 0.854 1A5E A H142Y Disease Disease 0.922 1A5E A R144C Disease Disease 0.938 1A5E A A148T Neutral Disease 0.893 1A5E A T148A *Neutral Neutral 0.001 1A5E A G150V Disease Disease 0.917 1A5E A L16P Disease Disease 0.943 1A5E A A20P Disease Disease 0.979 1A5E A A20S Disease Disease 0.912 1A5E A G23D Disease Disease 0.954 1A5E A R24C Disease Disease 0.922 1A5E A R24P Disease Disease 0.957 1A5E A E26D Disease Disease 0.699 1A5E A L32P Disease Disease 0.969 1A5E A E33D Disease Disease 0.834 1A5E A G35A Disease Disease 0.842 1A5E A G35E Disease Disease 0.728 1A5E A G35V Disease Disease 0.874 1A5E A P48L Disease Disease 0.872 1A5E A I49S Disease Disease 0.930 1A5E A I49T Neutral Disease 0.912 1A5E A T49I *Neutral Neutral 0.031 1A5E A Q50R Disease Disease 0.947 1A5E A M53I Disease Disease 0.945 1A5E A I56S *Neutral Neutral 0.033 1A5E A S56I Neutral Disease 0.892 1A5E A A57V Disease Disease 0.688 1A5E A Q58R *Neutral Neutral 0.094 1A5E A R58Q Neutral Disease 0.776 1A5E A V59G Disease Disease 0.900 1A5E A A60T Neutral Disease 0.907 1A5E A A60V Disease Disease 0.776 1A5E A T60A *Neutral Neutral 0.002 1A5E A L62P Disease Disease 0.948 1A5E A H66Y Disease Disease 0.514 1A5E A G67R Disease Disease 0.930 1A5E A A68L Disease Disease 0.939 1A5E A A68T Disease Disease 0.920 1A5E A A68V Neutral Disease 0.912 1A5E A V68A *Neutral Neutral 0.001 1A5E A E69K Disease Disease 0.858 1A5E A E69V Disease Disease 0.762 1A5E A N71K Disease Disease 0.957 1A5E A N71S Neutral Disease 0.937 1A5E A S71N *Neutral Neutral 0.006 1A5E A C72G Disease Disease 0.860 1A5E A D74N Disease Disease 0.949 1A5E A D74V Disease Disease 0.940 1A5E A D74Y Disease Disease 0.950 1A5E A T77P Disease Disease 0.955 1A5E A R80L Disease Disease 0.913 1A5E A R80P Disease Disease 0.968 1A5E A P81L Disease Disease 0.926 1A5E A P81T Disease Disease 0.934 1A5E A H83N Disease Disease 0.955 1A5E A H83Q Neutral Disease 0.921 1A5E A H83Y Disease Disease 0.956 1A5E A Q83H *Neutral Neutral 0.001 1A5E A D84E Disease Disease 0.943 1A5E A D84H Disease Disease 0.934 1A5E A D84N Disease Disease 0.952 1A5E A D84Y Disease Disease 0.955 1A5E A A85T Neutral Disease 0.936 1A5E A T85A *Neutral Neutral 0.001 1A5E A R87P Disease Disease 0.970 1A5E A R87W Disease Disease 0.926 1A5E A E88D Disease Disease 0.854 1A5E A G89D Disease Disease 0.959 1A5E A G89S Disease Disease 0.949 1A5E A T93A Disease Disease 0.896 1A5E A L94Q Disease Disease 0.896 1A5E A V95A Disease Disease 0.623 1A5E A L97R Disease Disease 0.949 1A5E A H98P Disease Disease 0.952 1A5E A H98Q Disease Disease 0.842 1A5E A R99P Disease Disease 0.959 1A5E A R99Q Disease Disease 0.697 1A5E A R99W Neutral Disease 0.905 1A5E A W99R *Neutral Neutral 0.037 1A6A B G135S Neutral Neutral 0.155 1A6A B S135G *Neutral Neutral 0.000 1A6A B A140T *Neutral Neutral 0.033 1A6A B T140A Neutral Neutral 0.000 1A6A B F26Y *Neutral Neutral 0.133 1A6A B Y26F Neutral Neutral 0.018 1A6A B N77T Neutral Neutral 0.001 1A6A B T77N *Neutral Neutral 0.304 1A6Z A Q105H Disease Neutral 0.023 1A6Z A A154V Disease Neutral 0.264 1A6Z A I195T *Neutral Neutral 0.035 1A6Z A T195I Neutral Neutral 0.060 1A6Z A R202G Disease Neutral 0.257 1A6Z A G21D Disease Neutral 0.181 1A6Z A E255K Neutral Neutral 0.262 1A6Z A K255E *Neutral Neutral 0.001 1A6Z A C260Y Disease Disease 0.637 1A6Z A Q261P Disease Neutral 0.262 1A6Z A V273A Disease Neutral 0.118 1A6Z A M31V *Neutral Neutral 0.000 1A6Z A V31M Neutral Neutral 0.204 1A6Z A M37V *Neutral Neutral 0.001 1A6Z A V37M Neutral Neutral 0.097 1A6Z A H41D Disease Neutral 0.110 1A6Z A S43C Disease Neutral 0.152 1A6Z A R44C Disease Neutral 0.155 1A6Z A G71R Disease Neutral 0.079 1A6Z A I83T Disease Neutral 0.112 1A81 A H45R *Neutral Neutral 0.006 1A81 A R45H Neutral Disease 0.635 1AD6 A K436Q *Neutral Neutral 0.236 1AD6 A Q436K Neutral Disease 0.666 1AD6 A K447Q Disease Disease 0.812 1AD6 A M457R Disease Disease 0.946 1AD6 A R500G Disease Disease 0.755 1AD6 A A525G Neutral Disease 0.918 1AD6 A G525A *Neutral Neutral 0.011 1AD6 A K530R Disease Disease 0.920 1AD6 A H549Y Disease Disease 0.973 1ADS A F14I *Neutral Neutral 0.155 1ADS A I14F Neutral Neutral 0.400 1ADS A G203S Neutral Disease 0.506 1ADS A S203G *Neutral Neutral 0.001 1ADS A I287T *Neutral Neutral 0.049 1ADS A T287I Neutral Neutral 0.082 1ADS A H41L Neutral Disease 0.594 1ADS A L41H *Neutral Neutral 0.002 1ADS A L72V Neutral Neutral 0.363 1ADS A V72L *Neutral Neutral 0.009 1ADS A E89K *Neutral Neutral 0.126 1ADS A K89E Neutral Neutral 0.086 1AGD A H113Y Neutral Neutral 0.003 1AGD A Y113H *Neutral Disease 0.533 1AGD A D114N *Neutral Neutral 0.252 1AGD A N114D Neutral Neutral 0.155 1AGD A D116Y *Neutral Neutral 0.018 1AGD A Y116D Neutral Neutral 0.292 1AGD A R131S Neutral Neutral 0.237 1AGD A S131R *Neutral Neutral 0.002 1AGD A E152V *Neutral Neutral 0.061 1AGD A V152E Neutral Neutral 0.159 1AGD A D156L Neutral Neutral 0.137 1AGD A D156R Neutral Neutral 0.072 1AGD A L156D *Neutral Neutral 0.144 1AGD A R156D *Neutral Neutral 0.294 1AGD A A41T Neutral Neutral 0.125 1AGD A T41A *Neutral Neutral 0.002 1AGD A D63N *Neutral Neutral 0.073 1AGD A K63N *Neutral Neutral 0.072 1AGD A N63D Neutral Neutral 0.452 1AGD A N63K Neutral Neutral 0.500 1AGD A F67S Neutral Neutral 0.056 1AGD A S67F *Neutral Neutral 0.124 1AGD A A73T *Neutral Neutral 0.006 1AGD A T73A Neutral Neutral 0.104 1AGD A D74Y Neutral Neutral 0.106 1AGD A Y74D *Neutral Neutral 0.218 1AGD A N77S *Neutral Neutral 0.163 1AGD A S77N Neutral Neutral 0.006 1AGD A L95W Neutral Disease 0.519 1AGD A W95L *Neutral Neutral 0.021 1AGD A R97S *Neutral Neutral 0.474 1AGD A S97R Neutral Neutral 0.025 1AGD A S97T Neutral Neutral 0.195 1AGD A T97S *Neutral Neutral 0.174 1AII A N20S *Neutral Neutral 0.154 1AII A S20N Neutral Neutral 0.052 1AII A I220N Neutral Neutral 0.303 1AII A N220I *Neutral Neutral 0.028 1AII A L252P *Neutral Neutral 0.019 1AII A P252L Neutral Disease 0.544 1AII A F292S Neutral Disease 0.764 1AII A S292F *Neutral Neutral 0.037 1ALD A D128G Disease Disease 0.973 1ALD A G141V Neutral Disease 0.993 1ALD A V141G *Neutral Neutral 0.003 1ALD A E206K Disease Disease 0.994 1ALD A C338Y Disease Disease 0.926 1ALD A G346S Disease Disease 0.951 1ALD A E81Q Neutral Disease 0.987 1ALD A Q81E *Neutral Neutral 0.004 1ALY A G116R Disease Neutral 0.341 1ALY A G116S Disease Neutral 0.367 1ALY A A123E Disease Disease 0.580 1ALY A H125R Disease Disease 0.699 1ALY A V126A Disease Disease 0.558 1ALY A V126D Disease Disease 0.595 1ALY A W140C Disease Disease 0.668 1ALY A W140G Disease Disease 0.564 1ALY A W140R Disease Disease 0.570 1ALY A K143T Disease Neutral 0.171 1ALY A G144E Disease Neutral 0.452 1ALY A T147N Disease Neutral 0.481 1ALY A L155P Disease Disease 0.743 1ALY A Y170C Disease Disease 0.655 1ALY A A173D Disease Neutral 0.500 1ALY A Q174R Disease Disease 0.645 1ALY A T176I Disease Neutral 0.382 1ALY A L195P Disease Disease 0.874 1ALY A A208D Disease Neutral 0.399 1ALY A T211N Disease Neutral 0.343 1ALY A G219R Neutral Disease 0.604 1ALY A R219G *Neutral Neutral 0.001 1ALY A H224Y Disease Neutral 0.316 1ALY A G226A Disease Disease 0.646 1ALY A G227V Disease Disease 0.634 1ALY A L231S Disease Disease 0.725 1ALY A A235P Disease Disease 0.749 1ALY A V237E Disease Disease 0.586 1ALY A T254M Disease Neutral 0.457 1ALY A G257D Disease Disease 0.693 1ALY A G257S Disease Disease 0.663 1ALY A L258S Disease Disease 0.568 1AML A A21G Disease Disease 0.812 1AML A E22G Disease Disease 0.806 1AML A E22K Disease Disease 0.832 1AML A E22Q Disease Disease 0.790 1AML A D23N Disease Disease 0.841 1AML A L34V Disease Disease 0.862 1AML A D7N Disease Disease 0.762 1APY A F112S Disease Disease 0.861 1APY A S126T Neutral Neutral 0.073 1APY A T126S *Neutral Neutral 0.047 1APY A R138Q Disease Neutral 0.134 1APY A C140S Disease Disease 0.830 1APY A G37D Disease Disease 0.854 1APY A S49P Disease Disease 0.638 1APY A G77E Disease Disease 0.951 1APY A A78V Disease Disease 0.876 1AUQ A P503L Disease Disease 0.838 1AUQ A H505D Disease Disease 0.873 1AUQ A C509R Disease Disease 0.948 1AUQ A R543W Disease Disease 0.929 1AUQ A R545C Disease Disease 0.862 1AUQ A W550C Disease Disease 0.704 1AUQ A V551L Disease Disease 0.819 1AUQ A V553M Disease Disease 0.881 1AUQ A V555L Disease Disease 0.547 1AUQ A G561S Disease Disease 0.850 1AUQ A R578Q Disease Disease 0.888 1AUQ A R611C Disease Disease 0.948 1AUQ A R611H Disease Disease 0.911 1AUQ A A618T Neutral Disease 0.557 1AUQ A T618A *Neutral Neutral 0.010 1AUQ A H636R *Neutral Neutral 0.001 1AUQ A R636H Neutral Disease 0.843 1AUQ A L697V Disease Disease 0.890 1AUQ A A698V Disease Disease 0.583 1AUT C P124L Disease Disease 0.745 1AUT C G127R Disease Neutral 0.500 1AUT C R128CC Disease Neutral 0.331 1AUT C R128CH Disease Neutral 0.158 1AUT C G133S Disease Disease 0.527 1AUT C T139M Disease Neutral 0.478 1AUT C V162A Disease Disease 0.635 1AUT C P164L Disease Neutral 0.458 1AUT C G186R Disease Neutral 0.248 1AUT C D194N Disease Disease 0.892 1AUT C G211D Disease Disease 0.900 1AUT C G216S Disease Disease 0.851 1AUT C C220Y Disease Disease 0.902 1AUT C T229N Disease Disease 0.731 1AUT C Y234H Disease Disease 0.682 1AUT C W237C Disease Disease 0.903 1AUT C R24Q Disease Neutral 0.386 1AUT C R24W Disease Neutral 0.431 1AUT C I47T Disease Disease 0.815 1AUT C R75C Disease Neutral 0.428 1AUT C P92L Disease Disease 0.562 1AWE A S148R Disease Disease 0.680 1AWE A L150P Disease Disease 0.908 1AWE A W32R Disease Disease 0.780 1AWE A E33K Disease Disease 0.784 1AWE A G34R Disease Disease 0.675 1AWE A C41Y Disease Disease 0.831 1AWL A L954P Disease Disease 0.915 1AZ7 A M107T Neutral Neutral 0.117 1AZ7 A T107M *Neutral Neutral 0.035 1AZ7 A D196N Neutral Neutral 0.355 1AZ7 A N196D *Neutral Neutral 0.005 1B1C A Y118D Disease Disease 0.778 1B1C A L165P *Neutral Neutral 0.012 1B1C A P165L Neutral Neutral 0.382 1B1I A P112L Disease Disease 0.980 1B1I A V113I Disease Disease 0.943 1B1I A H114R Disease Disease 0.964 1B1I A Q12L Disease Disease 0.981 1B1I A K17E Disease Neutral 0.290 1B1I A K17I Disease Neutral 0.500 1B1I A S28N Disease Disease 0.895 1B1I A R31K Disease Neutral 0.124 1B1I A C39W Disease Disease 0.971 1B1I A K40I Disease Disease 0.944 1B1I A E60K *Neutral Neutral 0.019 1B1I A K60E Neutral Disease 0.721 1B4R A R57L Disease Disease 0.873 1B6U A L11R Neutral Neutral 0.234 1B6U A R11L *Neutral Neutral 0.111 1B6U A H13Q Neutral Neutral 0.047 1B6U A Q13H *Neutral Neutral 0.223 1B6U A P16R Neutral Disease 0.565 1B6U A R16P *Neutral Neutral 0.020 1B6U A E35Q *Neutral Neutral 0.190 1B6U A Q35E Neutral Neutral 0.234 1B6U A F45Y Neutral Neutral 0.085 1B6U A Y45F *Neutral Neutral 0.048 1B6U A H50R Neutral Neutral 0.019 1B6U A R50H *Neutral Neutral 0.077 1BCI A G103R Neutral Disease 0.651 1BCI A R103G *Neutral Neutral 0.003 1BEH A N9S *Neutral Neutral 0.013 1BEH A S9N Neutral Neutral 0.136 1BH9 B F155S *Neutral Neutral 0.013 1BH9 B S155F Neutral Disease 0.678 1BHG A G136R Disease Disease 0.780 1BHG A P148S Disease Neutral 0.479 1BHG A E150K Disease Disease 0.786 1BHG A D152G Disease Disease 0.665 1BHG A L176F Disease Disease 0.519 1BHG A R216W Disease Disease 0.876 1BHG A L243P Disease Disease 0.605 1BHG A P30S Disease Disease 0.674 1BHG A Y320C Disease Disease 0.559 1BHG A Y320S Disease Neutral 0.388 1BHG A N339S Disease Disease 0.839 1BHG A K350N Disease Neutral 0.436 1BHG A H351Y Disease Disease 0.848 1BHG A A354V Disease Neutral 0.456 1BHG A D362N Disease Neutral 0.216 1BHG A P364L Disease Neutral 0.201 1BHG A R374C Disease Disease 0.736 1BHG A F376L *Neutral Neutral 0.335 1BHG A L376F Neutral Neutral 0.380 1BHG A C38G Disease Neutral 0.169 1BHG A R382C Disease Disease 0.926 1BHG A R382H Disease Disease 0.879 1BHG A P408S Disease Disease 0.614 1BHG A P415L Disease Neutral 0.175 1BHG A R435P Disease Disease 0.819 1BHG A R477W Disease Disease 0.890 1BHG A Y495C Disease Disease 0.548 1BHG A Y508C Disease Disease 0.827 1BHG A S52F Disease Neutral 0.248 1BHG A E540K Disease Disease 0.867 1BHG A G572D Disease Neutral 0.239 1BHG A R577L Disease Disease 0.700 1BHG A K606N Disease Disease 0.703 1BHG A G607A Disease Disease 0.796 1BHG A R611W Disease Disease 0.577 1BHG A A619V Disease Disease 0.628 1BHG A Y626H Disease Disease 0.777 1BHG A W627C Disease Disease 0.716 1BIO A V200G Disease Disease 0.783 1BIO A C201R Disease Disease 0.868 1BIO A I238M Neutral Disease 0.761 1BIO A M238I *Neutral Neutral 0.001 1BIX A D148E Neutral Neutral 0.409 1BIX A E148D *Neutral Neutral 0.085 1BIX A H51Q *Neutral Neutral 0.031 1BIX A Q51H Neutral Neutral 0.270 1BIX A I64V Neutral Neutral 0.455 1BIX A V64I *Neutral Neutral 0.007 1BLX A D110N Neutral Neutral 0.140 1BLX A N110D *Neutral Neutral 0.012 1BOY A A4T *Neutral Neutral 0.000 1BOY A T4A Neutral Neutral 0.180 1BQQ M I233V Neutral Neutral 0.459 1BQQ M V233I *Neutral Neutral 0.406 1BQQ M D273N Neutral Neutral 0.213 1BQQ M N273D *Neutral Neutral 0.061 1BQT A A67T Neutral Neutral 0.168 1BQT A T67A *Neutral Neutral 0.001 1BU1 A L105M *Neutral Disease 0.554 1BU1 A M105L Neutral Neutral 0.048 1BY8 A G64E Disease Disease 0.676 1BZ4 A A106V Neutral Neutral 0.418 1BZ4 A V106A *Neutral Neutral 0.010 1BZ4 A C112R Disease Neutral 0.023 1BZ4 A D127G *Neutral Neutral 0.001 1BZ4 A G127D Neutral Neutral 0.344 1BZ4 A Q134R *Neutral Neutral 0.006 1BZ4 A R134Q Neutral Neutral 0.085 1BZ4 A R136C Disease Disease 0.780 1BZ4 A R136S Disease Disease 0.704 1BZ4 A R142C Disease Disease 0.570 1BZ4 A R145C Disease Disease 0.707 1BZ4 A R145P Disease Disease 0.726 1BZ4 A K146E Disease Neutral 0.457 1BZ4 A K146Q Disease Neutral 0.340 1BZ4 A A152P Neutral Disease 0.718 1BZ4 A P152A *Neutral Neutral 0.004 1BZ4 A R158C Disease Disease 0.610 1BZ4 A R25C Disease Disease 0.517 1BZ4 A L28P Neutral Disease 0.591 1BZ4 A P28L *Neutral Neutral 0.008 1BZ4 A A42T *Neutral Neutral 0.007 1BZ4 A T42A Neutral Neutral 0.262 1BZ4 A H46Q *Neutral Neutral 0.002 1BZ4 A Q46H Neutral Neutral 0.337 1BZ4 A K81Q *Neutral Neutral 0.001 1BZ4 A Q81K Neutral Neutral 0.019 1BZ4 A P84R Neutral Disease 0.564 1BZ4 A R84P *Neutral Neutral 0.000 1BZ4 A A99T Neutral Neutral 0.311 1BZ4 A T99A *Neutral Neutral 0.002 1BZY A S103R Disease Disease 0.924 1BZY A S109L Disease Disease 0.949 1BZY A V129D Disease Disease 0.972 1BZY A L130S Disease Disease 0.970 1BZY A I131M Disease Disease 0.909 1BZY A I131T Disease Disease 0.947 1BZY A D134G Disease Disease 0.951 1BZY A M142K Disease Disease 0.959 1BZY A G15D Disease Disease 0.973 1BZY A G15S Disease Disease 0.968 1BZY A A160S Disease Disease 0.915 1BZY A S161R Disease Disease 0.903 1BZY A T167I Disease Disease 0.778 1BZY A P175L Disease Disease 0.860 1BZY A D176V Disease Disease 0.947 1BZY A D176Y Disease Disease 0.933 1BZY A I182T Disease Disease 0.934 1BZY A D19V Disease Disease 0.768 1BZY A D193E Disease Disease 0.968 1BZY A D193N Disease Disease 0.965 1BZY A Y194C Disease Disease 0.965 1BZY A F198V Disease Disease 0.947 1BZY A D200G Disease Disease 0.730 1BZY A D200N Disease Neutral 0.014 1BZY A D200Y Disease Disease 0.781 1BZY A H203D Disease Disease 0.879 1BZY A H203R Disease Disease 0.916 1BZY A C205Y Disease Disease 0.859 1BZY A L40P Disease Disease 0.911 1BZY A I41F Disease Disease 0.964 1BZY A I41T Disease Disease 0.958 1BZY A R44K Disease Disease 0.883 1BZY A R47H Disease Disease 0.890 1BZY A A49P Disease Disease 0.983 1BZY A A49V Disease Disease 0.956 1BZY A R50G Disease Disease 0.808 1BZY A R50P Disease Disease 0.932 1BZY A V52A Disease Disease 0.882 1BZY A V52M Disease Disease 0.822 1BZY A M53L Disease Disease 0.921 1BZY A M56T Disease Disease 0.920 1BZY A G57R Disease Disease 0.895 1BZY A G6D Disease Disease 0.964 1BZY A G69E Disease Disease 0.984 1BZY A V7G Disease Disease 0.862 1BZY A G70R Disease Disease 0.952 1BZY A F73L Disease Disease 0.969 1BZY A L77V Disease Disease 0.962 1BZY A D79V Disease Disease 0.747 1CB6 A A1010T Neutral Neutral 0.113 1CB6 A T1010A *Neutral Neutral 0.198 1CB6 A K1028R Neutral Neutral 0.112 1CB6 A R1028K *Neutral Neutral 0.091 1CB6 A I1129T Neutral Disease 0.685 1CB6 A T1129I *Neutral Neutral 0.023 1CB6 A C1403G *Neutral Neutral 0.004 1CB6 A G1403C Neutral Disease 0.927 1CB6 A D1560E *Neutral Neutral 0.011 1CB6 A E1560D Neutral Neutral 0.201 1CD8 A G90S Disease Disease 0.823 1CDF A L124S *Neutral Neutral 0.055 1CDF A S124L Neutral Neutral 0.101 1CDF A C26Q Disease Disease 0.857 1CDF A S35G Disease Neutral 0.001 1CDF A S39T Disease Neutral 0.458 1CDF A C83R Disease Disease 0.892 1CDZ A Q22R *Neutral Neutral 0.000 1CDZ A R22Q Neutral Disease 0.810 1CDZ A R23W Neutral Disease 0.796 1CDZ A W23R *Neutral Neutral 0.000 1CDZ A S39Y *Neutral Neutral 0.000 1CDZ A Y39S Neutral Disease 0.843 1CEA A H31Q Neutral Disease 0.840 1CEA A Q31H *Neutral Neutral 0.001 1CEA A K32R *Neutral Neutral 0.042 1CEA A R32K Neutral Neutral 0.188 1CEE B L41P Disease Disease 0.963 1CFH A G12A Disease Disease 0.838 1CFH A G12R Disease Disease 0.834 1CFH A N2I Disease Disease 0.645 1CFH A E20V Disease Disease 0.707 1CFH A E21K Disease Disease 0.905 1CFH A F25S Disease Disease 0.694 1CFH A E27K Disease Disease 0.879 1CFH A E27V Disease Disease 0.768 1CFH A R29Q Disease Disease 0.857 1CFH A S3P Disease Disease 0.890 1CFH A E33D Disease Disease 0.848 1CFH A T38R Disease Disease 0.874 1CFH A Y45C Disease Disease 0.924 1CFH A D47G Disease Disease 0.801 1CFH A L6S Disease Disease 0.738 1CFH A E7A Disease Disease 0.797 1CFH A E8G Disease Disease 0.818 1CFH A F9C Disease Disease 0.729 1CGH A N119S Neutral Neutral 0.100 1CGH A S119N *Neutral Neutral 0.322 1CI6 A D322E *Neutral Neutral 0.000 1CI6 A E322D Neutral Disease 0.956 1CSK A L45P *Neutral Neutral 0.000 1CSK A P45L Neutral Disease 0.794 1CTQ A K117R Disease Disease 0.678 1CTQ A G12A Disease Neutral 0.312 1CTQ A G12C Disease Disease 0.645 1CTQ A G12E Disease Disease 0.629 1CTQ A G12S Disease Neutral 0.017 1CTQ A G12V Disease Neutral 0.494 1CTQ A G13C Disease Disease 0.735 1CTQ A G13D Disease Disease 0.641 1CTQ A A146T Disease Disease 0.573 1CTQ A A146V Disease Disease 0.557 1CTQ A Q22K Disease Disease 0.754 1CTQ A T58I Disease Disease 0.832 1CTQ A Q61L Disease Disease 0.812 1CTQ A E63K Disease Neutral 0.213 1CYN A L28V *Neutral Neutral 0.165 1CYN A V28L Neutral Neutral 0.490 1D1S A A79G *Neutral Neutral 0.002 1D1S A G79A Neutral Neutral 0.463 1D3B L P79S *Neutral Neutral 0.000 1D3B L S79P Neutral Disease 0.924 1D4A A R138W Neutral Neutral 0.421 1D4A A W138R *Neutral Neutral 0.059 1D4A A P186S Neutral Neutral 0.372 1D4A A S186P *Neutral Neutral 0.005 1D4A A H268Q *Neutral Neutral 0.000 1D4A A Q268H Neutral Disease 0.853 1D4T A P101L Disease Disease 0.546 1D4T A V102G Disease Disease 0.736 1D4T A G16D Disease Disease 0.637 1D4T A G27S Disease Disease 0.850 1D4T A S28R Disease Disease 0.618 1D4T A L31P Disease Disease 0.839 1D4T A R32T Disease Disease 0.914 1D4T A D33Y Disease Disease 0.789 1D4T A C42W Disease Disease 0.783 1D4T A G49V Disease Neutral 0.336 1D4T A T53I Disease Disease 0.700 1D4T A Y54C Disease Disease 0.878 1D4T A R55L Disease Disease 0.854 1D4T A T68I Disease Neutral 0.387 1D4T A Y7C Disease Disease 0.866 1D4T A H8D Disease Disease 0.825 1D4T A I84T Disease Disease 0.578 1D4T A F87S Disease Disease 0.522 1D4T A Q99P Disease Disease 0.682 1D4X G A78T Neutral Disease 0.924 1D4X G T78A *Neutral Neutral 0.001 1D5G A L59P Neutral Disease 0.876 1D5G A P59L *Neutral Neutral 0.002 1D8J A I68T Neutral Neutral 0.106 1D8J A T68I *Neutral Neutral 0.167 1DEV A L440R Disease Disease 0.965 1DEV A P445H Disease Disease 0.979 1DEV A D450E Disease Disease 0.973 1DK8 A L143R Disease Disease 0.939 1DL6 A P19S Neutral Disease 0.886 1DL6 A S19P *Neutral Neutral 0.001 1DPU A N203S Neutral Disease 0.807 1DPU A S203N *Neutral Neutral 0.000 1DS6 A D57N Disease Disease 0.769 1E27 A R131S *Neutral Neutral 0.315 1E27 A S131R Neutral Neutral 0.004 1E27 A E152V Neutral Neutral 0.057 1E27 A V152E *Neutral Neutral 0.071 1E27 A D156L *Neutral Neutral 0.161 1E27 A L156D Neutral Neutral 0.243 1E27 A G167W *Neutral Neutral 0.003 1E27 A W167G Neutral Neutral 0.412 1E27 A H171Y Neutral Neutral 0.001 1E27 A Y171H *Neutral Disease 0.536 1E4J A R15S *Neutral Neutral 0.349 1E4J A S15R Neutral Neutral 0.145 1E4J A N44S *Neutral Neutral 0.014 1E4J A S44N Neutral Neutral 0.062 1E4J A A57D Neutral Neutral 0.177 1E4J A D57A *Neutral Neutral 0.038 1E4J A D61N *Neutral Neutral 0.009 1E4J A N61D Neutral Neutral 0.108 1E4J A I85V Neutral Neutral 0.117 1E4J A V85I *Neutral Neutral 0.060 1E4U A A7G Neutral Disease 0.756 1E4U A G7A *Neutral Neutral 0.117 1E50 C R174Q Disease Disease 0.881 1E96 B A128V Disease Disease 0.656 1E96 B K181R Neutral Neutral 0.027 1E96 B R181K *Neutral Neutral 0.309 1E96 B R77Q Disease Neutral 0.453 1E96 B G78E Disease Disease 0.886 1EAX A G216R Disease Disease 0.844 1EB1 H P37T Neutral Neutral 0.008 1EB1 H T37P *Neutral Neutral 0.014 1EEM A A140D Neutral Neutral 0.104 1EEM A D140A *Neutral Neutral 0.014 1EEM A E208K Neutral Neutral 0.122 1EEM A K208E *Neutral Neutral 0.007 1EEM A A236V Neutral Disease 0.728 1EEM A V236A *Neutral Neutral 0.000 1EEM A C86S *Neutral Neutral 0.000 1EEM A S86C Neutral Disease 0.861 1EF7 A A225T Neutral Neutral 0.217 1EF7 A T225A *Neutral Neutral 0.017 1EFV A G116R Disease Disease 0.917 1EFV A V157G Disease Disease 0.699 1EFV A I171T *Neutral Neutral 0.028 1EFV A T171I Neutral Neutral 0.500 1EFV A T266M Disease Disease 0.559 1EFV B D128N Disease Disease 0.808 1EFV B M154T *Neutral Neutral 0.197 1EFV B T154M Neutral Neutral 0.204 1EFV B R164Q Disease Disease 0.884 1EFX A L103V *Neutral Neutral 0.030 1EFX A V103L Neutral Neutral 0.106 1EFX A D114V Neutral Neutral 0.383 1EFX A V114D *Neutral Neutral 0.116 1EFX A S116Y *Neutral Neutral 0.052 1EFX A Y116S Neutral Disease 0.634 1EFX A M248V *Neutral Neutral 0.003 1EFX A V248M Neutral Neutral 0.233 1EFX A A49E Neutral Disease 0.794 1EFX A E49A *Neutral Neutral 0.001 1EFX A M52V *Neutral Neutral 0.177 1EFX A V52M Neutral Neutral 0.014 1EFX A K66N Neutral Neutral 0.042 1EFX A N66K *Neutral Neutral 0.112 1EFX A N77S *Neutral Neutral 0.223 1EFX A S77N Neutral Neutral 0.008 1EFX A K80N *Neutral Neutral 0.084 1EFX A N80K Neutral Neutral 0.407 1EFX A G91R Neutral Disease 0.670 1EFX A R91G *Neutral Neutral 0.000 1EFX A I94T Neutral Neutral 0.001 1EFX A T94I *Neutral Neutral 0.386 1EFX A I95L Neutral Neutral 0.066 1EFX A L95I *Neutral Neutral 0.166 1EFX A R97S Neutral Disease 0.573 1EFX A S97R *Neutral Neutral 0.031 1EG3 A F228L Disease Neutral 0.139 1EGE A M124I Disease Disease 0.553 1EGE A T168A Disease Disease 0.712 1EGE A G170R Disease Disease 0.913 1EGE A R181L Disease Disease 0.728 1EGE A C219R Disease Disease 0.559 1EGE A S220L Disease Disease 0.821 1EGE A G242R Disease Disease 0.907 1EGE A R256T Disease Disease 0.888 1EGE A R28C Disease Disease 0.791 1EGE A G285R Disease Disease 0.654 1EGE A M301T Disease Disease 0.850 1EGE A K304E Disease Neutral 0.122 1EGE A S311R Disease Disease 0.500 1EGE A Y327C Disease Disease 0.594 1EGE A I350T Disease Disease 0.686 1EGE A Y42H Disease Neutral 0.450 1EGE A I53T Disease Disease 0.661 1EGE A C91Y Disease Disease 0.818 1EGE A T96I Disease Neutral 0.372 1EGX A A104T Neutral Neutral 0.304 1EGX A T104A *Neutral Neutral 0.373 1EK6 A D103G Disease Neutral 0.245 1EK6 A E165K Disease Disease 0.824 1EK6 A R169W Disease Disease 0.623 1EK6 A A180V Neutral Disease 0.671 1EK6 A V180A *Neutral Neutral 0.353 1EK6 A L183P Disease Disease 0.904 1EK6 A R239W Disease Disease 0.922 1EK6 A A25V Disease Disease 0.512 1EK6 A K257R Disease Neutral 0.237 1EK6 A G302D Disease Disease 0.809 1EK6 A L313M Disease Neutral 0.233 1EK6 A G319E Disease Disease 0.717 1EK6 A R335H Disease Neutral 0.399 1EK6 A N34S Disease Disease 0.582 1EK6 A R40C Disease Disease 0.715 1EK6 A D69E Disease Disease 0.639 1EK6 A G90E Disease Disease 0.759 1EK6 A V94M Disease Disease 0.675 1EKG A L106S Disease Disease 0.966 1EKG A D122Y Disease Disease 0.921 1EKG A G130V Disease Disease 0.966 1EKG A I154F Disease Disease 0.974 1EKG A W155R Disease Disease 0.977 1EKG A R165C Disease Disease 0.991 1EKG A L182F Disease Disease 0.978 1EKG A L198R Disease Disease 0.903 1EKG A C202S *Neutral Neutral 0.003 1EKG A S202C Neutral Disease 0.855 1EMN A D2127E Disease Disease 0.836 1EMN A C2142Y Disease Disease 0.933 1EMN A N2144S Disease Disease 0.865 1EMN A C2151W Disease Disease 0.925 1EMN A P2154R Disease Neutral 0.323 1EMN A A2160P Disease Neutral 0.411 1EMN A C2170F Neutral Disease 0.909 1EMN A F2170C *Neutral Neutral 0.001 1EOT A K63T Neutral Neutral 0.136 1EOT A T63K *Neutral Neutral 0.001 1EQF A I1383V *Neutral Neutral 0.003 1EQF A V1383I Neutral Disease 0.871 1EU0 A K312Q *Neutral Neutral 0.000 1EU0 A Q312K Neutral Disease 0.919 1EXT A H22Q Disease Disease 0.633 1EXT A C30R Disease Disease 0.773 1EXT A C30S Disease Disease 0.780 1EXT A C33G Disease Disease 0.747 1EXT A C33Y Disease Disease 0.754 1EXT A P46L Disease Neutral 0.422 1EXT A T50M Disease Neutral 0.433 1EXT A C52F Disease Disease 0.731 1EXT A C70S Disease Disease 0.816 1EXT A S86G Disease Disease 0.542 1EXT A C88R Disease Disease 0.717 1EXT A C88Y Disease Disease 0.726 1EXT A R92P Disease Disease 0.828 1EXT A R92Q Disease Neutral 0.411 1EXZ B A229T *Neutral Neutral 0.003 1EXZ B T229A Neutral Neutral 0.306 1F0Y A H140Q *Neutral Neutral 0.340 1F0Y A Q140H Neutral Neutral 0.279 1F0Y A P246L Disease Disease 0.822 1F0Y A A28T Disease Disease 0.747 1F0Y A D45E Disease Neutral 0.451 1F0Y A L74P *Neutral Neutral 0.063 1F0Y A P74L Neutral Neutral 0.235 1F16 A G108V Disease Disease 0.978 1F16 A G39R Neutral Disease 0.923 1F16 A R39G *Neutral Neutral 0.044 1F16 A G67R Disease Disease 0.970 1F41 A C10R Disease Disease 0.762 1F41 A G101S Neutral Disease 0.634 1F41 A S101G *Neutral Neutral 0.000 1F41 A P102R Neutral Neutral 0.197 1F41 A R102P *Neutral Neutral 0.266 1F41 A C104R *Neutral Neutral 0.148 1F41 A H104R *Neutral Neutral 0.331 1F41 A R104C Neutral Disease 0.670 1F41 A R104H Neutral Neutral 0.004 1F41 A T106N Disease Disease 0.736 1F41 A I107M Disease Disease 0.565 1F41 A I107V Disease Neutral 0.182 1F41 A L111M Disease Disease 0.711 1F41 A Y114C Disease Disease 0.655 1F41 A Y114H Disease Disease 0.522 1F41 A Y116S Disease Disease 0.659 1F41 A L12P Disease Disease 0.959 1F41 A A120S Disease Disease 0.568 1F41 A V122A Disease Disease 0.747 1F41 A V122I Disease Disease 0.592 1F41 A N124S Disease Neutral 0.131 1F41 A I13M *Neutral Neutral 0.002 1F41 A M13I Neutral Disease 0.755 1F41 A D18E Disease Disease 0.840 1F41 A D18G Disease Disease 0.815 1F41 A V20I Disease Neutral 0.415 1F41 A S23N Disease Neutral 0.490 1F41 A P24S Disease Disease 0.626 1F41 A V28M Disease Neutral 0.230 1F41 A V30A Disease Disease 0.632 1F41 A V30G Disease Disease 0.639 1F41 A V30L Disease Neutral 0.109 1F41 A V30M Disease Disease 0.505 1F41 A F33I Disease Disease 0.700 1F41 A F33L Disease Disease 0.762 1F41 A F33V Disease Disease 0.780 1F41 A R34T Disease Disease 0.567 1F41 A K35N Disease Neutral 0.452 1F41 A A36P Disease Disease 0.655 1F41 A D38A Disease Neutral 0.363 1F41 A D38V Disease Neutral 0.356 1F41 A W41L Disease Disease 0.750 1F41 A E42D Disease Neutral 0.378 1F41 A E42G Disease Neutral 0.484 1F41 A F44S Disease Disease 0.602 1F41 A A45D Disease Disease 0.722 1F41 A A45S Disease Neutral 0.500 1F41 A A45T Disease Neutral 0.463 1F41 A G47A Disease Disease 0.695 1F41 A G47E Disease Disease 0.740 1F41 A G47R Disease Disease 0.691 1F41 A G47V Disease Disease 0.663 1F41 A T49A Disease Disease 0.707 1F41 A T49I Disease Disease 0.682 1F41 A S50I Disease Neutral 0.186 1F41 A S50R Disease Neutral 0.206 1F41 A S52P Disease Neutral 0.403 1F41 A G53E Disease Disease 0.847 1F41 A E54G Disease Disease 0.632 1F41 A E54K Disease Disease 0.765 1F41 A L55P Disease Disease 0.747 1F41 A L55Q Disease Neutral 0.408 1F41 A L58H Disease Disease 0.754 1F41 A L58R Disease Disease 0.784 1F41 A T59K Disease Disease 0.625 1F41 A T60A Disease Neutral 0.321 1F41 A E61G Disease Neutral 0.173 1F41 A E61K Disease Neutral 0.194 1F41 A F64L Disease Disease 0.710 1F41 A I68L Disease Neutral 0.099 1F41 A Y69H Disease Disease 0.855 1F41 A K70N Disease Disease 0.794 1F41 A V71A Disease Disease 0.645 1F41 A I73V Disease Neutral 0.397 1F41 A D74H Neutral Disease 0.661 1F41 A H74D *Neutral Neutral 0.001 1F41 A S77Y Disease Neutral 0.352 1F41 A Y78F Disease Neutral 0.500 1F41 A I84N Disease Neutral 0.379 1F41 A I84S Disease Neutral 0.225 1F41 A I84T Disease Neutral 0.357 1F41 A E89K Disease Disease 0.571 1F41 A E89Q Disease Neutral 0.209 1F41 A H90N Neutral Neutral 0.308 1F41 A N90H *Neutral Neutral 0.045 1F41 A A91S Disease Disease 0.698 1F41 A A97G Disease Disease 0.773 1F41 A A97S Disease Disease 0.758 1F67 A L122V Disease Neutral 0.421 1F67 A R130C Disease Disease 0.672 1F67 A N247S Disease Neutral 0.125 1FB1 A M102K Disease Disease 0.963 1FB1 A M102R Disease Disease 0.936 1FB1 A T106I Disease Disease 0.944 1FB1 A G108D Disease Disease 0.987 1FB1 A D115N Disease Disease 0.765 1FB1 A D134V Disease Disease 0.972 1FB1 A I135K Disease Disease 0.989 1FB1 A C141R Disease Disease 0.990 1FB1 A C141W Disease Disease 0.989 1FB1 A H144P Disease Disease 0.992 1FB1 A H153P Disease Disease 0.997 1FB1 A L163R Disease Disease 0.957 1FB1 A S176T Disease Disease 0.961 1FB1 A R178S Disease Disease 0.989 1FB1 A Q180R Disease Disease 0.987 1FB1 A R184H Disease Disease 0.951 1FB1 A T186K Disease Disease 0.990 1FB1 A V191I Disease Disease 0.787 1FB1 A P199L Disease Disease 0.980 1FB1 A G201E Disease Disease 0.995 1FB1 A G203R Disease Disease 0.989 1FB1 A M211I Disease Disease 0.964 1FB1 A M211V Disease Disease 0.975 1FB1 A M213V Disease Disease 0.923 1FB1 A M221T Disease Disease 0.612 1FB1 A K224R Disease Disease 0.553 1FB1 A F234S Disease Disease 0.989 1FB1 A R241W Disease Disease 0.981 1FB1 A R249S Disease Disease 0.903 1FB1 A L71Q Disease Disease 0.907 1FB1 A A74V Disease Disease 0.963 1FB1 A L79P Disease Disease 0.991 1FB1 A G83A Disease Disease 0.955 1FB1 A R88P Disease Disease 0.989 1FB1 A R88W Disease Disease 0.976 1FB1 A G90V Disease Disease 0.978 1FDH G I75T Neutral Neutral 0.242 1FDH G T75I *Neutral Neutral 0.247 1FDQ A M60T *Neutral Neutral 0.004 1FDQ A T60M Neutral Neutral 0.439 1FLT X E144K Neutral Neutral 0.101 1FLT X K144E *Neutral Neutral 0.020 1FNA A R21S *Neutral Neutral 0.002 1FNA A S21R Neutral Neutral 0.291 1FNH A W114R Disease Disease 0.941 1FNH A L163R Disease Disease 0.882 1FNH A I240V Neutral Neutral 0.344 1FNH A V240I *Neutral Neutral 0.114 1FP5 A L478W *Neutral Neutral 0.000 1FP5 A W478L Neutral Disease 0.907 1FQ3 A H245Y *Neutral Neutral 0.000 1FQ3 A Y245H Neutral Neutral 0.034 1FQ3 A Q48R Neutral Neutral 0.115 1FQ3 A R48Q *Neutral Neutral 0.451 1FQ3 A A88P *Neutral Disease 0.657 1FQ3 A P88A Neutral Neutral 0.088 1FSB A G20R Neutral Disease 0.678 1FSB A R20G *Neutral Neutral 0.000 1FV1 B K12T Neutral Neutral 0.255 1FV1 B T12K *Neutral Neutral 0.000 1FV1 B A125G *Neutral Neutral 0.004 1FV1 B G125A Neutral Neutral 0.058 1FV1 B H33N *Neutral Neutral 0.000 1FV1 B N33H Neutral Neutral 0.306 1FV1 B Q4R *Neutral Neutral 0.001 1FV1 B R4Q Neutral Neutral 0.090 1FV1 B N77T *Neutral Neutral 0.001 1FV1 B T77N Neutral Neutral 0.391 1FV4 H R306T Disease Neutral 0.167 1FV4 H I359T Disease Disease 0.794 1FV4 H M385T Neutral Neutral 0.238 1FV4 H T385M *Neutral Neutral 0.098 1FV4 H K485R *Neutral Neutral 0.063 1FV4 H R485K Neutral Neutral 0.022 1FV4 H Q506R *Neutral Neutral 0.026 1FV4 H R506Q Neutral Neutral 0.280 1FV4 H C585R Disease Disease 0.596 1FV4 H D79H Neutral Neutral 0.270 1FV4 H H79D *Neutral Neutral 0.044 1FXL A D159G Neutral Neutral 0.500 1FXL A G159D *Neutral Neutral 0.002 1FZC B R166C Disease Neutral 0.464 1FZC B L235P *Neutral Neutral 0.005 1FZC B P235L Neutral Disease 0.531 1FZC B L353R Disease Disease 0.849 1FZC B G400D Disease Disease 0.882 1FZC B K448R *Neutral Neutral 0.234 1FZC B R448K Neutral Neutral 0.005 1FZC C H114Y *Neutral Neutral 0.013 1FZC C Y114H Neutral Neutral 0.144 1G1T A I10M *Neutral Neutral 0.001 1G1T A M10I Neutral Neutral 0.442 1G1T A C109W Neutral Disease 0.791 1G1T A W109C *Neutral Neutral 0.000 1G1T A R128S *Neutral Neutral 0.001 1G1T A S128R Neutral Neutral 0.500 1G3M A D22Y Neutral Neutral 0.039 1G3M A Y22D *Neutral Neutral 0.063 1G5Y B L261P *Neutral Neutral 0.099 1G5Y B P261L Neutral Disease 0.911 1G5Y B A327S Neutral Disease 0.716 1G5Y B S327A *Neutral Neutral 0.115 1G5Y B I336S *Neutral Neutral 0.268 1G5Y B S336I Neutral Disease 0.920 1G5Y B A398V Neutral Disease 0.764 1G5Y B V398A *Neutral Neutral 0.351 1G86 A A28V *Neutral Neutral 0.002 1G86 A V28A Neutral Neutral 0.362 1GEN A L621V *Neutral Neutral 0.177 1GEN A V621L Neutral Neutral 0.232 1GG3 A I5V *Neutral Neutral 0.001 1GG3 A V5I Neutral Disease 0.524 1GLK A M107T Neutral Neutral 0.428 1GLK A T107M *Neutral Neutral 0.142 1GLK A Y108H Disease Disease 0.822 1GLK A A11T Neutral Neutral 0.337 1GLK A T11A *Neutral Neutral 0.005 1GLK A I110T Disease Disease 0.843 1GLK A A119D Disease Disease 0.877 1GLK A S131P Disease Disease 0.813 1GLK A H137R Disease Disease 0.562 1GLK A F150S Disease Disease 0.959 1GLK A L164P Disease Disease 0.980 1GLK A T168P Disease Disease 0.946 1GLK A G175R Disease Disease 0.711 1GLK A V182M Disease Disease 0.868 1GLK A A188T Disease Disease 0.878 1GLK A V203A Disease Disease 0.890 1GLK A T209M Disease Disease 0.926 1GLK A M210K Disease Disease 0.974 1GLK A M210T Disease Disease 0.957 1GLK A C213R Disease Disease 0.744 1GLK A E221K Disease Disease 0.698 1GLK A V226M Disease Disease 0.883 1GLK A G227C Disease Disease 0.981 1GLK A T228M Disease Disease 0.839 1GLK A E256K Disease Disease 0.962 1GLK A W257R Disease Disease 0.952 1GLK A A259T Disease Disease 0.811 1GLK A G261E Disease Disease 0.923 1GLK A G261R Disease Disease 0.884 1GLK A E279Q Disease Neutral 0.388 1GLK A G299R Disease Disease 0.960 1GLK A E300K Disease Disease 0.960 1GLK A E300Q Disease Disease 0.917 1GLK A L309P Disease Disease 0.926 1GLK A S336L Disease Disease 0.869 1GLK A R36W Disease Disease 0.815 1GLK A V367M Disease Disease 0.865 1GLK A C382Y Disease Disease 0.873 1GLK A A384T Disease Disease 0.920 1GLK A G385V Disease Disease 0.942 1GLK A R392C Disease Disease 0.920 1GLK A K414E Disease Neutral 0.111 1GLK A V455M Disease Disease 0.683 1GLK A A53S Disease Neutral 0.178 1GLK A E70K Disease Disease 0.965 1GLK A G80A Disease Disease 0.948 1GLK A G80S Disease Disease 0.944 1GMY A L12P *Neutral Neutral 0.047 1GMY A P12L Neutral Neutral 0.356 1GMY A N156S *Neutral Neutral 0.078 1GMY A S156N Neutral Neutral 0.065 1GO4 G M500T *Neutral Neutral 0.004 1GO4 G T500M Neutral Neutral 0.098 1GO4 G E511K Neutral Disease 0.557 1GO4 G K511E *Neutral Neutral 0.001 1GO4 G E516K Disease Disease 0.710 1GO4 G R556C Disease Disease 0.640 1GO4 G R556H Disease Neutral 0.301 1GO4 G R558H Disease Neutral 0.060 1GO4 G E569K Disease Neutral 0.500 1GO4 G R572H Disease Disease 0.651 1GP0 A G1619R Neutral Disease 0.822 1GP0 A R1619G *Neutral Neutral 0.001 1GR3 A Y582D Disease Disease 0.881 1GR3 A C591R Disease Disease 0.916 1GR3 A G595E Disease Disease 0.911 1GR3 A G595R Disease Disease 0.885 1GR3 A Y597C Disease Disease 0.887 1GR3 A Y597H Disease Disease 0.837 1GR3 A Y598D Disease Disease 0.802 1GR3 A S600P Disease Disease 0.821 1GR3 A M603V *Neutral Neutral 0.035 1GR3 A V603M Neutral Disease 0.608 1GR3 A L614P Disease Disease 0.969 1GR3 A N617K Disease Disease 0.710 1GR3 A G618V Disease Disease 0.627 1GR3 A L644R Disease Disease 0.894 1GR3 A D648G Disease Disease 0.831 1GR3 A W651R Disease Disease 0.827 1GR3 A Q653P Disease Disease 0.945 1GR3 A S671P Disease Disease 0.712 1GUL A L100P Neutral Disease 0.573 1GUL A P100L *Neutral Neutral 0.125 1GUL A A163T *Neutral Neutral 0.140 1GUL A T163A Neutral Neutral 0.030 1GXC A R145P Disease Disease 0.984 1GXC A R145W Disease Disease 0.958 1GXC A I157T Neutral Disease 0.876 1GXC A T157I *Neutral Neutral 0.015 1GXC A G167R Disease Disease 0.962 1GXC A R180C Disease Disease 0.943 1GXC A R180H Disease Disease 0.905 1GXC A R181C Disease Disease 0.856 1GXC A R181H Disease Disease 0.790 1GXE A N115K Disease Disease 0.995 1GXE A E119D Disease Disease 0.992 1GXE A D130N Disease Disease 0.994 1GXE A R14H Disease Disease 0.983 1GXE A R28H Disease Disease 0.994 1GXE A R28P Disease Disease 1.000 1GXE A L29H Disease Disease 0.994 1GXE A R93C Disease Disease 0.983 1H2I A R70W Neutral Disease 0.724 1H2I A W70R *Neutral Neutral 0.023 1H4R A E106G Disease Neutral 0.178 1H4R A L141P Disease Disease 0.958 1H4R A G197C Disease Disease 0.918 1H4R A N220Y Disease Disease 0.611 1H4R A L234R Disease Disease 0.925 1H4R A I273F Disease Disease 0.791 1H4R A F62S Disease Disease 0.921 1H4R A M77V Disease Neutral 0.368 1H6I A D165G *Neutral Neutral 0.002 1H6I A G165D Neutral Neutral 0.090 1H6I A A45V Neutral Neutral 0.076 1H6I A V45A *Neutral Neutral 0.004 1HCC A D10E *Neutral Neutral 0.022 1HCC A E10D Neutral Neutral 0.255 1HCC A Q24H Disease Disease 0.810 1HCC A Y25H Disease Neutral 0.463 1HCC A T30M Disease Disease 0.566 1HCC A C33Y Disease Disease 0.917 1HCC A W52C Disease Disease 0.913 1HCN B H10R *Neutral Neutral 0.116 1HCN B R10H Neutral Disease 0.690 1HCN B I15T *Neutral Neutral 0.001 1HCN B T15I Neutral Disease 0.566 1HCN B K2R Neutral Neutral 0.001 1HCN B R2K *Neutral Neutral 0.214 1HCN B D77N *Neutral Disease 0.601 1HCN B N77D Neutral Neutral 0.001 1HCN B R8W Neutral Disease 0.627 1HCN B W8R *Neutral Neutral 0.221 1HDO A Q46R *Neutral Neutral 0.018 1HDO A R46Q Neutral Neutral 0.159 1HDR A W107G Disease Disease 0.820 1HDR A L13P Disease Disease 0.979 1HDR A P144L Disease Disease 0.562 1HDR A G148R Disease Disease 0.938 1HDR A Y149C Disease Disease 0.966 1HDR A G150S Disease Disease 0.933 1HDR A H157Y Disease Disease 0.937 1HDR A G16R Disease Disease 0.979 1HDR A G16V Disease Disease 0.971 1HDR A G169S Disease Disease 0.783 1HDR A G17D Disease Disease 0.965 1HDR A F211C Disease Disease 0.907 1HDR A G22D Disease Disease 0.978 1HDR A W35R Disease Disease 0.809 1HDR A S50T Neutral Disease 0.697 1HDR A T50S *Neutral Neutral 0.053 1HDR A Q65R Disease Disease 0.770 1HDR A L73P Disease Disease 0.891 1HFC A I191V Neutral Neutral 0.278 1HFC A V191I *Neutral Neutral 0.005 1HFC A D252G Neutral Disease 0.732 1HFC A G252D *Neutral Neutral 0.001 1HFC A R262S Neutral Neutral 0.362 1HFC A S262R *Neutral Neutral 0.011 1HFH A I25S *Neutral Neutral 0.020 1HFH A S25I Neutral Neutral 0.195 1HFH A H28R Disease Disease 0.736 1HFH A C50S Disease Disease 0.937 1HI7 A A10D Disease Disease 0.815 1HI7 A E13K Disease Disease 0.824 1HI7 A G31V Disease Disease 0.823 1HI7 A T8I Disease Neutral 0.402 1HI7 A T8K Disease Disease 0.786 1HJ7 A H306Y Disease Disease 0.963 1HJ7 A C308Y Disease Disease 0.976 1HJ7 A C317S Disease Disease 0.978 1HJ7 A D321N Disease Disease 0.713 1HJ7 A R329P Disease Disease 0.981 1HJ7 A D335Y Disease Disease 0.924 1HJ7 A Q345R Disease Disease 0.960 1HJ7 A C347R Disease Disease 0.970 1HJ7 A C358Y Disease Disease 0.957 1HJ7 A A370T Neutral Neutral 0.081 1HJ7 A T370A *Neutral Disease 0.555 1HJX A G145R *Neutral Neutral 0.032 1HJX A R145G Neutral Neutral 0.290 1HJX A I311T Neutral Neutral 0.319 1HJX A T311I *Neutral Neutral 0.103 1HK0 X M102V Neutral Neutral 0.422 1HK0 X V102M *Neutral Neutral 0.008 1HK0 X E107A Disease Neutral 0.420 1HK0 X R14C Disease Disease 0.818 1HK0 X P23S Disease Neutral 0.073 1HK0 X P23T Disease Neutral 0.284 1HK0 X R58H Disease Disease 0.653 1HKB A L529S Disease Disease 0.946 1HKB A T680S Disease Disease 0.962 1HKB A L776M Neutral Disease 0.906 1HKB A M776L *Neutral Neutral 0.006 1HKF A M57V Neutral Neutral 0.247 1HKF A V57M *Neutral Neutral 0.009 1HLC A I119V *Neutral Neutral 0.071 1HLC A V119I Neutral Neutral 0.050 1HLI A Q284R *Neutral Neutral 0.100 1HLI A R284Q Neutral Disease 0.585 1HML A I27V Neutral Neutral 0.024 1HML A V27I *Neutral Neutral 0.336 1HR4 A D108N Neutral Neutral 0.157 1HR4 A N108D *Neutral Neutral 0.051 1HR4 A P7S Disease Disease 0.816 1HR4 A S82P Disease Disease 0.783 1HRJ A F1S *Neutral Neutral 0.003 1HRJ A S1F Neutral Neutral 0.153 1HRY A F12V Disease Disease 0.951 1HRY A I13T Disease Disease 0.838 1HRY A R21S Disease Disease 0.924 1HRY A M23T Disease Disease 0.887 1HRY A N32Y Disease Disease 0.910 1HRY A I35M Disease Disease 0.850 1HRY A S36G Disease Disease 0.885 1HRY A G40E Disease Disease 0.970 1HRY A G40R Disease Disease 0.954 1HRY A L46H Disease Disease 0.873 1HRY A V5A Disease Disease 0.908 1HRY A V5L Disease Disease 0.927 1HRY A K51I Disease Disease 0.889 1HRY A P53R Disease Disease 0.905 1HRY A F54S Disease Disease 0.951 1HRY A A58T Disease Disease 0.886 1HRY A R7G Disease Disease 0.963 1HRY A P70L Disease Disease 0.934 1HRY A Y72C Disease Disease 0.973 1HRY A Y72F Disease Disease 0.956 1HRY A M9I Disease Disease 0.948 1HRY A M9R Disease Disease 0.952 1HSB A P105S *Neutral Neutral 0.148 1HSB A S105P Neutral Neutral 0.013 1HSB A F109L Neutral Neutral 0.006 1HSB A L109F *Neutral Neutral 0.239 1HSB A E114R *Neutral Neutral 0.170 1HSB A H114R *Neutral Neutral 0.216 1HSB A R114E Neutral Neutral 0.347 1HSB A R114H Neutral Neutral 0.414 1HSB A D116H Neutral Neutral 0.219 1HSB A D116V Neutral Neutral 0.425 1HSB A D116Y Neutral Neutral 0.042 1HSB A H116D *Neutral Neutral 0.287 1HSB A V116D *Neutral Neutral 0.219 1HSB A Y116D *Neutral Neutral 0.444 1HSB A M12V *Neutral Neutral 0.001 1HSB A V12M Neutral Neutral 0.159 1HSB A H151L Neutral Neutral 0.304 1HSB A L151H *Neutral Neutral 0.116 1HSB A L156W *Neutral Neutral 0.113 1HSB A Q156W *Neutral Neutral 0.134 1HSB A W156L Neutral Neutral 0.206 1HSB A W156Q Neutral Neutral 0.149 1HSB A G65R *Neutral Neutral 0.009 1HSB A R65G Neutral Neutral 0.280 1HSB A H70Q *Neutral Neutral 0.144 1HSB A Q70H Neutral Neutral 0.062 1HSB A I73T *Neutral Neutral 0.006 1HSB A T73I Neutral Neutral 0.094 1HSB A D74H Neutral Neutral 0.261 1HSB A H74D *Neutral Neutral 0.182 1HSB A D77N Neutral Neutral 0.005 1HSB A N77D *Neutral Neutral 0.392 1HSB A M97R Neutral Neutral 0.049 1HSB A R97M *Neutral Neutral 0.475 1HUM A S57T Neutral Neutral 0.033 1HUM A T57S *Neutral Neutral 0.023 1HUP A N194Y Neutral Disease 0.621 1HUP A Y194N *Neutral Neutral 0.001 1HW8 C I638V Neutral Neutral 0.447 1HW8 C V638I *Neutral Neutral 0.015 1HY9 A L86M Neutral Disease 0.824 1HY9 A M86L *Neutral Neutral 0.000 1HYN Q R112S Neutral Neutral 0.040 1HYN Q S112R *Neutral Neutral 0.078 1HYN Q G130R Disease Neutral 0.464 1HYN Q P147S Disease Neutral 0.364 1HYN Q A285D Disease Disease 0.654 1HYN Q P327R Disease Neutral 0.189 1HYN Q E56K *Neutral Disease 0.713 1HYN Q K56E Neutral Neutral 0.012 1HYN Q E68K Neutral Neutral 0.398 1HYN Q K68E *Neutral Neutral 0.012 1HYN Q D72E *Neutral Neutral 0.004 1HYN Q E72D Neutral Neutral 0.345 1HYN Q L73M Neutral Neutral 0.057 1HYN Q M73L *Neutral Neutral 0.389 1HYN Q E90K Disease Neutral 0.397 1HZD A A240V Disease Disease 0.845 1I0Z A M174V Neutral Disease 0.615 1I0Z A V174M *Neutral Neutral 0.440 1I10 A R160S *Neutral Neutral 0.211 1I10 A S160R Neutral Disease 0.884 1I10 A E221K *Neutral Neutral 0.067 1I10 A K221E Neutral Neutral 0.162 1I1R A G126R Neutral Neutral 0.111 1I1R A R126G *Neutral Neutral 0.083 1I3D A I75T Neutral Neutral 0.337 1I3D A T75I *Neutral Neutral 0.129 1I4M A M129V Neutral Disease 0.912 1I4M A V129M *Neutral Neutral 0.001 1I4M A G131V Disease Disease 0.874 1I4M A N171S Neutral Neutral 0.376 1I4M A S171N *Neutral Neutral 0.002 1I4M A D178N Disease Disease 0.912 1I4M A V180I Disease Disease 0.725 1I4M A H187R Disease Disease 0.767 1I4M A R188T *Neutral Neutral 0.000 1I4M A T188R Neutral Disease 0.633 1I4M A E196K Disease Disease 0.703 1I4M A F198S Disease Disease 0.783 1I4M A E200K Disease Disease 0.789 1I4M A D202N Disease Disease 0.799 1I4M A V203I Disease Neutral 0.073 1I4M A R208H Disease Disease 0.740 1I4M A V210I Disease Neutral 0.261 1I4M A E211Q Disease Disease 0.528 1I4M A Q212P Disease Disease 0.919 1I4M A Q217R Disease Disease 0.896 1I4M A E219K Neutral Neutral 0.470 1I4M A K219E *Neutral Neutral 0.051 1I5J A K19T Neutral Neutral 0.099 1I5J A T19K *Neutral Neutral 0.026 1I5J A W26R Disease Neutral 0.500 1I5J A E38K Neutral Neutral 0.057 1I5J A K38E *Neutral Neutral 0.004 1I5J A K55Q Neutral Neutral 0.265 1I5J A Q55K *Neutral Neutral 0.000 1I5R A A237V Neutral Disease 0.539 1I5R A V237A *Neutral Neutral 0.001 1I76 A E134G *Neutral Neutral 0.002 1I76 A G134E Neutral Neutral 0.424 1I76 A D173V Neutral Disease 0.670 1I76 A V173D *Neutral Neutral 0.001 1I76 A N226Y Neutral Neutral 0.062 1I76 A Y226N *Neutral Neutral 0.008 1IAT A V100M Disease Disease 0.728 1IAT A G158S Disease Disease 0.980 1IAT A H19P Disease Disease 0.914 1IAT A T194I Disease Disease 0.744 1IAT A I207T Neutral Disease 0.880 1IAT A T207I *Neutral Neutral 0.074 1IAT A T223M Disease Disease 0.734 1IAT A R272H Disease Disease 0.973 1IAT A S277L Disease Disease 0.955 1IAT A A299P Disease Disease 0.988 1IAT A H307R *Neutral Neutral 0.038 1IAT A R307H Neutral Disease 0.844 1IAT A L338P Disease Disease 0.981 1IAT A Q342R Disease Disease 0.900 1IAT A R346C Disease Disease 0.962 1IAT A R346H Disease Disease 0.914 1IAT A T374R Disease Disease 0.930 1IAT A H388R Disease Disease 0.927 1IAT A T4I Disease Disease 0.874 1IAT A R471H Disease Disease 0.939 1IAT A L486F Disease Disease 0.932 1IAT A E494K Disease Disease 0.982 1IAT A L516V Disease Disease 0.872 1IAT A I524T Disease Disease 0.871 1IAT A D538N Disease Disease 0.870 1IAT A R74G Disease Disease 0.892 1IAT A R82W Disease Disease 0.877 1IC1 A K128N Neutral Neutral 0.015 1IC1 A N128K *Neutral Neutral 0.006 1IC1 A K29M Neutral Neutral 0.005 1IC1 A M29K *Neutral Neutral 0.005 1IC1 A C7S *Neutral Neutral 0.004 1IC1 A S7C Neutral Neutral 0.019 1IFY A Q179R *Neutral Neutral 0.475 1IFY A R179Q Neutral Neutral 0.020 1IFY A M200T *Neutral Neutral 0.017 1IFY A T200M Neutral Neutral 0.278 1IHB A M126T *Neutral Disease 0.842 1IHB A T126M Neutral Disease 0.716 1IHB A A72P Disease Disease 0.979 1IHK A I94V Neutral Neutral 0.339 1IHK A V94I *Neutral Neutral 0.011 1IK2 A D107E Neutral Disease 0.990 1IK2 A E107D *Neutral Disease 0.996 1IK2 A Y115H Disease Disease 1.000 1IK2 A T124I Disease Disease 1.000 1IK2 A R143G Disease Disease 1.000 1IK2 A R143Q Disease Disease 0.996 1IK2 A R143W Disease Disease 1.000 1IK2 A K146N Disease Disease 0.984 1IK2 A S148I Disease Disease 0.973 1IK2 A Y162C Disease Disease 1.000 1IK2 A V186L Disease Disease 0.997 1IK2 A N187K Disease Disease 1.000 1IK2 A T188N Disease Disease 1.000 1IK2 A R190T Disease Disease 1.000 1IK2 A A196T Disease Disease 0.996 1IK2 A I201T Disease Disease 0.987 1IK2 A R204H Disease Disease 0.994 1IK2 A K207Q Disease Disease 0.934 1IK2 A P211L Disease Disease 0.987 1IK2 A Q222K Disease Disease 1.000 1IK2 A A223T Disease Disease 0.996 1IK2 A L227V Disease Disease 1.000 1IK2 A N232S Disease Disease 1.000 1IK2 A F244L Disease Disease 1.000 1IK2 A R249Q Disease Disease 0.995 1IK2 A G256E Disease Disease 1.000 1IK2 A A26V Disease Disease 0.995 1IK2 A I263M Disease Disease 0.996 1IK2 A I263T Disease Disease 1.000 1IK2 A A3D *Neutral Neutral 0.039 1IK2 A D3A Neutral Disease 0.996 1IK2 A F312C Disease Disease 1.000 1IK2 A V320M Disease Disease 0.996 1IK2 A E328G Disease Disease 0.995 1IK2 A M349T Disease Disease 0.997 1IK2 A K351E Disease Disease 0.996 1IK2 A A355T Disease Disease 1.000 1IK2 A K383N Disease Disease 0.997 1IK2 A A385V Disease Disease 1.000 1IK2 A V39M Disease Disease 0.991 1IK2 A L390V Disease Disease 0.943 1IK2 A R403L Disease Disease 1.000 1IK2 A R403Q Disease Disease 0.995 1IK2 A R403W Disease Disease 0.997 1IK2 A V404L Disease Disease 0.991 1IK2 A V404M Disease Disease 0.977 1IK2 A V406M Disease Disease 0.987 1IK2 A G407V Disease Disease 0.995 1IK2 A V411I Disease Disease 0.866 1IK2 A T412N Disease Disease 0.990 1IK2 A G425R Disease Disease 1.000 1IK2 A A428V Disease Disease 1.000 1IK2 A A430E Disease Disease 1.000 1IK2 A M435T Disease Disease 0.997 1IK2 A V440M Disease Disease 1.000 1IK2 A T441M Disease Disease 0.989 1IK2 A I443T Disease Disease 1.000 1IK2 A K450E Disease Disease 0.974 1IK2 A K450T Disease Disease 0.966 1IK2 A R453C Disease Disease 0.997 1IK2 A R453H Disease Disease 0.993 1IK2 A E466Q Neutral Disease 1.000 1IK2 A Q466E *Neutral Neutral 0.105 1IK2 A N479S Disease Disease 1.000 1IK2 A E483K Disease Disease 1.000 1IK2 A E499K Disease Disease 0.995 1IK2 A E500A Disease Disease 0.996 1IK2 A Y501C Disease Disease 1.000 1IK2 A I511F Disease Disease 0.995 1IK2 A I511T Disease Disease 0.993 1IK2 A F513C Disease Disease 1.000 1IK2 A M515R Disease Disease 0.978 1IK2 A M515V Disease Disease 0.954 1IK2 A L517M Disease Disease 0.993 1IK2 A S532P Disease Disease 1.000 1IK2 A A550V Disease Disease 0.991 1IK2 A G571R Disease Disease 0.996 1IK2 A H576R Disease Disease 0.997 1IK2 A G584R Disease Disease 1.000 1IK2 A G584S Disease Disease 1.000 1IK2 A D587V Disease Disease 0.992 1IK2 A V59I Disease Disease 0.969 1IK2 A Q595R Disease Disease 0.996 1IK2 A L601V Disease Disease 0.993 1IK2 A N602S Disease Disease 0.990 1IK2 A V606M Disease Disease 0.992 1IK2 A K615N Disease Disease 0.988 1IK2 A K615Q Disease Disease 0.988 1IK2 A S642L Disease Disease 0.989 1IK2 A M659I Disease Disease 0.997 1IK2 A R663C Disease Disease 0.997 1IK2 A R663H Disease Disease 0.989 1IK2 A R663S Disease Disease 0.977 1IK2 A R671C Disease Disease 1.000 1IK2 A R694C Disease Disease 1.000 1IK2 A R694H Disease Disease 1.000 1IK2 A N696S Disease Disease 0.989 1IK2 A V698A Disease Disease 1.000 1IK2 A R712L Disease Disease 1.000 1IK2 A G716R Disease Disease 0.996 1IK2 A R719Q Disease Disease 0.997 1IK2 A R719W Disease Disease 0.996 1IK2 A R723C Disease Disease 0.997 1IK2 A R723G Disease Disease 0.985 1IK2 A A728V Disease Disease 0.990 1IK2 A P731L Disease Disease 0.996 1IK2 A G733E Disease Disease 0.997 1IK2 A Q734E Disease Disease 0.968 1IK2 A Q734P Disease Disease 0.991 1IK2 A I736M Disease Disease 0.958 1IK2 A I736T Disease Disease 0.978 1IK2 A G741R Disease Disease 1.000 1IK2 A G741W Disease Disease 1.000 1IK2 A A742E Disease Disease 0.996 1IK2 A E743D Disease Disease 0.995 1IK2 A V763G Disease Disease 0.995 1IK2 A V763M Disease Disease 0.994 1IK2 A F764L Disease Disease 1.000 1IK2 A G768R Disease Disease 0.997 1IK2 A E774V Disease Disease 1.000 1IK2 A D778E Disease Disease 0.979 1IK2 A D778G Disease Disease 0.988 1IK2 A D778V Disease Disease 0.992 1IK2 A S782N Disease Disease 0.975 1IK2 A R787C Disease Disease 0.996 1IK2 A R787H Disease Disease 0.992 1IK2 A L796F Disease Disease 0.996 1IK2 A A797T Disease Disease 0.993 1IK2 A M822L Disease Disease 0.842 1IK2 A M822T Disease Disease 0.996 1IK2 A G823E Disease Disease 0.995 1IK2 A V824I Disease Disease 0.964 1IKT A M112V Neutral Neutral 0.152 1IKT A V112M *Neutral Neutral 0.015 1IKT A I71T *Neutral Neutral 0.001 1IKT A T71I Neutral Disease 0.766 1IL6 A D135E Neutral Neutral 0.034 1IL6 A D135V Neutral Neutral 0.100 1IL6 A E135D *Neutral Neutral 0.001 1IL6 A V135D *Neutral Neutral 0.001 1ILL G A100V Disease Disease 0.565 1ILL G L106H Disease Neutral 0.384 1ILL G L116P Disease Disease 0.842 1ILL G L116Q Disease Disease 0.600 1ILL G E12G Disease Disease 0.555 1ILL G E12K Disease Disease 0.595 1ILL G C126R Disease Disease 0.706 1ILL G L127S Disease Disease 0.568 1ILL G R166C Disease Disease 0.746 1ILL G R168W Disease Disease 0.744 1ILL G R170C Disease Disease 0.754 1ILL G R170H Disease Disease 0.662 1ILL G F171C Disease Neutral 0.330 1ILL G L174P Disease Neutral 0.243 1ILL G C175Y Disease Disease 0.507 1ILL G G176R Disease Neutral 0.391 1ILL G W184C Disease Disease 0.808 1ILL G S185I Disease Disease 0.680 1ILL G N28K Disease Disease 0.666 1ILL G Y33C Disease Disease 0.745 1ILL G Y49C Disease Disease 0.843 1ILL G E53K Neutral Neutral 0.031 1ILL G K53E *Neutral Neutral 0.013 1ILL G G58D Disease Disease 0.840 1ILL G C59F Disease Disease 0.837 1ILL G C59R Disease Disease 0.854 1ILL G C6G Disease Disease 0.785 1ILL G H67P Disease Neutral 0.135 1ILL G Y69N Disease Neutral 0.367 1ILL G Q88P Disease Neutral 0.500 1ILL G I97N Disease Neutral 0.427 1ILM B F57S *Neutral Neutral 0.002 1ILM B S57F Neutral Neutral 0.388 1IOJ A S45T *Neutral Neutral 0.001 1IOJ A T45S Neutral Disease 0.646 1IRD A F10V *Neutral Neutral 0.005 1IRD A V10F Neutral Disease 0.670 1IRD A R102S *Neutral Neutral 0.020 1IRD A S102R Neutral Neutral 0.305 1IRD A L44P *Neutral Neutral 0.013 1IRD A P44L Neutral Neutral 0.112 1IRD A D59G *Neutral Neutral 0.000 1IRD A G59D Neutral Disease 0.925 1IRD A K60N Neutral Disease 0.511 1IRD A N60K *Neutral Neutral 0.002 1IRD A K68N *Neutral Neutral 0.116 1IRD A N68K Neutral Neutral 0.154 1IRD A F91L *Neutral Neutral 0.000 1IRD A L91F Neutral Disease 0.758 1IRD A L91P Neutral Disease 0.869 1IRD A P91L *Neutral Neutral 0.000 1IRD B H202L Neutral Neutral 0.454 1IRD B H202Q Neutral Neutral 0.273 1IRD B L202H *Neutral Neutral 0.003 1IRD B Q202H *Neutral Neutral 0.003 1IRD B P205R Neutral Neutral 0.081 1IRD B R205P *Neutral Neutral 0.251 1IRD B E206V Neutral Neutral 0.316 1IRD B V206E *Neutral Neutral 0.007 1IRD B E207G Neutral Disease 0.776 1IRD B G207E *Neutral Neutral 0.018 1IRD B E208K *Neutral Neutral 0.002 1IRD B K208E Neutral Disease 0.748 1IRD B D211V *Neutral Neutral 0.022 1IRD B V211D Neutral Disease 0.870 1IRD B A213D Neutral Neutral 0.440 1IRD B D213A *Neutral Neutral 0.024 1IRD B G215W *Neutral Neutral 0.003 1IRD B W215G Neutral Disease 0.869 1IRD B E217K *Neutral Neutral 0.001 1IRD B K217E Neutral Disease 0.823 1IRD B M218V *Neutral Neutral 0.025 1IRD B V218M Neutral Disease 0.515 1IRD B G267V *Neutral Neutral 0.001 1IRD B V267G Neutral Disease 0.780 1IRD B L281V Neutral Disease 0.721 1IRD B V281L *Neutral Neutral 0.012 1IRY A M83V *Neutral Neutral 0.002 1IRY A V83M Neutral Disease 0.793 1ITA A D13N *Neutral Neutral 0.001 1ITA A N13D Neutral Neutral 0.394 1ITA A D26N Neutral Disease 0.693 1ITA A N26D *Neutral Neutral 0.000 1ITA A D64H Neutral Neutral 0.166 1ITA A H64D *Neutral Neutral 0.000 1ITB B A107G Neutral Neutral 0.201 1ITB B G107A *Neutral Neutral 0.080 1IVH A L13P Disease Disease 0.859 1IVH A G170V Disease Disease 0.872 1IVH A R21P Disease Disease 0.848 1IVH A A282V Disease Disease 0.526 1IVH A C328R Disease Disease 0.848 1IVH A V342A Disease Disease 0.578 1IVH A R363C Disease Disease 0.904 1IVH A R382L Disease Disease 0.776 1IVH A D40N Disease Disease 0.733 1IVT A R435C Disease Disease 0.701 1IVT A D446V Disease Disease 0.745 1IVT A R453W Disease Disease 0.808 1IVT A N456I Disease Disease 0.840 1IVT A G465D Disease Disease 0.830 1IVT A R471C Disease Disease 0.884 1IVT A Y481H Disease Disease 0.804 1IVT A R482L Disease Disease 0.734 1IVT A R482Q Disease Disease 0.564 1IVT A R482W Disease Disease 0.700 1IVT A K486N Disease Neutral 0.227 1IVT A R527C Disease Disease 0.685 1IVT A R527H Disease Disease 0.548 1IVT A R527P Disease Disease 0.818 1IVT A T528R Disease Disease 0.798 1IVT A A529V Disease Neutral 0.293 1IVT A L530P Disease Disease 0.962 1IVT A R541H Disease Disease 0.865 1IVT A R541S Disease Disease 0.824 1IVT A K542N Disease Disease 0.659 1IYF A V15M Disease Disease 0.890 1IYF A R33Q Disease Neutral 0.422 1IYF A P37L Disease Disease 0.748 1IYF A R42P Disease Disease 0.968 1IYF A A46P Disease Disease 0.958 1IYT A A42T Disease Disease 0.761 1IYT A A42V Neutral Disease 0.786 1IYT A V42A *Neutral Neutral 0.000 1J3S A G41S Disease Disease 0.967 1J3S A K55R Neutral Disease 0.891 1J3S A R55K *Neutral Neutral 0.357 1J7D A E36G Neutral Disease 0.829 1J7D A G36E *Neutral Neutral 0.017 1J7D A D40H Neutral Disease 0.878 1J7D A H40D *Neutral Neutral 0.001 1J7D A P78Q Neutral Disease 0.906 1J7D A Q78P *Neutral Neutral 0.005 1J86 A K59R Neutral Neutral 0.031 1J86 A R59K *Neutral Neutral 0.057 1J86 A N76S *Neutral Neutral 0.000 1J86 A S76N Neutral Disease 0.794 1J8U A T124I Disease Neutral 0.416 1J8U A D129Y Disease Disease 0.925 1J8U A D143G Disease Disease 0.789 1J8U A D145V Disease Disease 0.780 1J8U A H146Y Disease Disease 0.942 1J8U A G148S Disease Disease 0.922 1J8U A D151H Disease Disease 0.903 1J8U A Y154N Disease Disease 0.947 1J8U A R155P Disease Disease 0.972 1J8U A R157N Disease Disease 0.955 1J8U A R158Q Disease Disease 0.915 1J8U A R158W Disease Disease 0.922 1J8U A Q160P Disease Disease 0.756 1J8U A F161S Disease Disease 0.840 1J8U A I164T Disease Disease 0.740 1J8U A N167I Disease Disease 0.523 1J8U A N167S Disease Neutral 0.341 1J8U A R169H Disease Disease 0.694 1J8U A H170D Disease Disease 0.827 1J8U A H170R Disease Disease 0.803 1J8U A G171A Disease Disease 0.834 1J8U A G171R Disease Disease 0.881 1J8U A P173T Disease Disease 0.775 1J8U A I174T Disease Disease 0.823 1J8U A I174V Disease Disease 0.568 1J8U A P175A Disease Disease 0.759 1J8U A R176L Disease Disease 0.734 1J8U A R176P Disease Disease 0.869 1J8U A V177L Disease Disease 0.781 1J8U A E178G Disease Neutral 0.494 1J8U A E183Q Disease Disease 0.868 1J8U A V190A Disease Disease 0.831 1J8U A L194P Disease Disease 0.931 1J8U A H201R Disease Neutral 0.123 1J8U A H201Y Disease Disease 0.598 1J8U A Y204C Disease Disease 0.506 1J8U A E205A Disease Disease 0.717 1J8U A Y206D Disease Disease 0.919 1J8U A N207D Disease Disease 0.607 1J8U A N207S Disease Disease 0.613 1J8U A P211T Disease Neutral 0.297 1J8U A L212P Disease Disease 0.847 1J8U A L213P Disease Disease 0.973 1J8U A C217G Disease Disease 0.761 1J8U A G218V Disease Disease 0.847 1J8U A E221G Disease Disease 0.556 1J8U A D222V Disease Disease 0.749 1J8U A I224M Disease Disease 0.838 1J8U A P225R Disease Disease 0.925 1J8U A P225T Disease Disease 0.929 1J8U A V230I Disease Neutral 0.182 1J8U A S231F Disease Disease 0.770 1J8U A S231P Disease Disease 0.909 1J8U A F233L Disease Disease 0.806 1J8U A T238P Disease Disease 0.966 1J8U A G239S Disease Disease 0.920 1J8U A F240S Disease Disease 0.884 1J8U A R241C Disease Disease 0.775 1J8U A R241H Disease Disease 0.687 1J8U A R241L Disease Disease 0.717 1J8U A L242F Disease Disease 0.809 1J8U A R243Q Disease Disease 0.901 1J8U A P244L Disease Disease 0.865 1J8U A V245A Disease Disease 0.812 1J8U A V245E Disease Disease 0.938 1J8U A V245L Disease Disease 0.926 1J8U A A246D Disease Disease 0.852 1J8U A G247V Disease Disease 0.889 1J8U A L248P Disease Disease 0.875 1J8U A L249F Disease Disease 0.796 1J8U A R252G Disease Disease 0.756 1J8U A R252Q Disease Disease 0.721 1J8U A R252W Disease Disease 0.814 1J8U A L255S Disease Disease 0.889 1J8U A L255V Disease Disease 0.861 1J8U A G257C Disease Disease 0.800 1J8U A A259T Disease Disease 0.913 1J8U A A259V Disease Disease 0.906 1J8U A R261P Disease Disease 0.961 1J8U A R261Q Disease Disease 0.878 1J8U A F263L Disease Disease 0.925 1J8U A H264L Disease Disease 0.819 1J8U A C265G Disease Disease 0.763 1J8U A I269L Disease Disease 0.819 1J8U A R270K Disease Disease 0.978 1J8U A R270S Disease Disease 0.959 1J8U A H271Y Disease Disease 0.858 1J8U A S273F Disease Disease 0.527 1J8U A E274K *Neutral Neutral 0.492 1J8U A K274E Neutral Neutral 0.074 1J8U A M276I Disease Disease 0.512 1J8U A M276V Disease Disease 0.559 1J8U A Y277C Disease Disease 0.899 1J8U A Y277D Disease Disease 0.872 1J8U A T278A Disease Disease 0.600 1J8U A T278N Disease Disease 0.735 1J8U A E280K Disease Disease 0.954 1J8U A P281L Disease Disease 0.872 1J8U A D282N Disease Disease 0.938 1J8U A I283F Disease Disease 0.751 1J8U A I283N Disease Disease 0.884 1J8U A R297C Disease Disease 0.708 1J8U A R297H Disease Disease 0.568 1J8U A F299C Disease Disease 0.935 1J8U A A300S Disease Disease 0.892 1J8U A A300V Disease Disease 0.881 1J8U A S303P Disease Disease 0.900 1J8U A Q304R Disease Disease 0.873 1J8U A I306V Disease Disease 0.679 1J8U A A309D Disease Disease 0.907 1J8U A A309V Disease Disease 0.818 1J8U A S310F Disease Disease 0.828 1J8U A L311P Disease Disease 0.978 1J8U A P314H Disease Disease 0.548 1J8U A I318T Disease Disease 0.704 1J8U A A322G Disease Disease 0.749 1J8U A A322T Disease Disease 0.813 1J8U A Y325C Disease Disease 0.938 1J8U A E330D Disease Disease 0.960 1J8U A F331L Disease Disease 0.955 1J8U A L333F Disease Disease 0.958 1J8U A C334S Disease Disease 0.811 1J8U A G337V Disease Neutral 0.196 1J8U A D338Y Disease Neutral 0.283 1J8U A K341R Disease Neutral 0.053 1J8U A K341T Disease Disease 0.764 1J8U A A342T Disease Disease 0.875 1J8U A Y343C Disease Disease 0.947 1J8U A G344R Disease Disease 0.960 1J8U A G344V Disease Disease 0.951 1J8U A A345S Disease Disease 0.936 1J8U A A345T Disease Disease 0.930 1J8U A L347F Disease Disease 0.859 1J8U A L348V Disease Disease 0.807 1J8U A S349L Disease Disease 0.911 1J8U A S349P Disease Disease 0.956 1J8U A S350T Disease Disease 0.830 1J8U A C357G Disease Disease 0.664 1J8U A P362T Disease Disease 0.700 1J8U A P366H Disease Disease 0.560 1J8U A T372S Disease Disease 0.644 1J8U A Y377C Disease Disease 0.750 1J8U A T380M Disease Neutral 0.326 1J8U A Y386C Disease Disease 0.940 1J8U A Y387H Disease Disease 0.768 1J8U A V388L Disease Disease 0.886 1J8U A V388M Disease Disease 0.820 1J8U A E390G Disease Disease 0.677 1J8U A D394A Disease Disease 0.604 1J8U A D394H Disease Disease 0.543 1J8U A A395G Disease Disease 0.796 1J8U A A395P Disease Disease 0.923 1J8U A A403V Disease Disease 0.650 1J8U A P407S Disease Neutral 0.261 1J8U A R408Q Disease Disease 0.898 1J8U A R408W Disease Disease 0.916 1J8U A F410S Disease Disease 0.934 1J8U A R413P Disease Disease 0.924 1J8U A R413S Disease Disease 0.827 1J8U A Y414C Disease Disease 0.939 1J8U A D415N Disease Neutral 0.055 1J8U A T418P Disease Disease 0.932 1J9U A Q110R *Neutral Neutral 0.003 1J9U A R110Q Neutral Neutral 0.296 1JDW A H110Q *Neutral Neutral 0.098 1JDW A Q110H Neutral Neutral 0.431 1JEI A S53F Disease Disease 0.783 1JHB A D47Y Neutral Disease 0.606 1JHB A Y47D *Neutral Neutral 0.028 1JJ7 A I518V *Neutral Neutral 0.026 1JJ7 A V518I Neutral Neutral 0.188 1JJ7 A D637G Neutral Neutral 0.000 1JJ7 A G637D *Neutral Disease 0.810 1JJ7 A Q648R *Neutral Neutral 0.061 1JJ7 A R648Q Neutral Disease 0.879 1JJ7 A R659Q Disease Disease 0.777 1JJ7 A Q708R Neutral Neutral 0.212 1JJ7 A R708Q *Neutral Disease 0.550 1JK7 A F152S Neutral Disease 0.716 1JK7 A S152F *Neutral Neutral 0.007 1JK8 B I116V *Neutral Neutral 0.000 1JK8 B V116I Neutral Neutral 0.183 1JK8 B D162E *Neutral Neutral 0.000 1JK8 B E162D Neutral Neutral 0.307 1JK8 B L165P *Neutral Neutral 0.000 1JK8 B P165L Neutral Neutral 0.225 1JM7 A E10K Disease Disease 0.986 1JM7 A L22S Disease Disease 0.986 1JM7 A E23K Disease Disease 0.991 1JM7 A C61G Disease Disease 0.987 1JM7 A C64G Disease Disease 0.983 1JM7 A C64Y Neutral Disease 0.986 1JM7 A Y64C *Neutral Neutral 0.005 1JM7 A R71K Disease Disease 0.987 1JMC A A351T *Neutral Neutral 0.284 1JMC A T351A Neutral Neutral 0.247 1JMJ B L110V Neutral Neutral 0.205 1JMJ B V110L *Neutral Neutral 0.158 1JMJ B R189H Disease Neutral 0.190 1JMJ B K218R Neutral Neutral 0.148 1JMJ B R218K *Neutral Neutral 0.172 1JMJ B M423T *Neutral Neutral 0.228 1JMJ B T423M Neutral Neutral 0.149 1JMJ B E428K Disease Disease 0.818 1JMJ B P443L Disease Neutral 0.224 1JPY A I125V *Neutral Neutral 0.000 1JPY A V125I Neutral Disease 0.687 1JPY A E96G Neutral Neutral 0.500 1JPY A G96E *Neutral Neutral 0.001 1JQD B I105T *Neutral Neutral 0.007 1JQD B T105I Neutral Neutral 0.108 1JR2 A A104V Disease Disease 0.900 1JR2 A K124R Neutral Disease 0.528 1JR2 A R124K *Neutral Neutral 0.062 1JR2 A I129T Disease Disease 0.953 1JR2 A G171V *Neutral Neutral 0.125 1JR2 A V171G Neutral Neutral 0.301 1JR2 A G188R Disease Disease 0.635 1JR2 A G188W Disease Disease 0.821 1JR2 A Y19C Disease Disease 0.956 1JR2 A S212P Disease Disease 0.839 1JR2 A I219S Disease Disease 0.727 1JR2 A G225S Disease Disease 0.929 1JR2 A T228M Disease Disease 0.930 1JR2 A V3F Disease Disease 0.944 1JR2 A L4F Disease Disease 0.915 1JR2 A S47P Disease Disease 0.873 1JR2 A P53L Disease Disease 0.865 1JR2 A T62A Disease Disease 0.933 1JR2 A A66V Disease Disease 0.953 1JR2 A A69T Disease Disease 0.929 1JR2 A C73R Disease Disease 0.897 1JR2 A V82F Disease Disease 0.613 1JR2 A V99A Disease Disease 0.969 1JSF A I56T Disease Disease 0.702 1JSF A D67H Disease Neutral 0.391 1JSF A N70T *Neutral Neutral 0.006 1JSF A T70N Neutral Disease 0.560 1JSG A I56V *Neutral Neutral 0.000 1JSG A V56I Neutral Neutral 0.399 1K04 A D1030E Neutral Disease 0.795 1K04 A E1030D *Neutral Neutral 0.000 1K13 A M110T *Neutral Neutral 0.366 1K13 A T110M Neutral Neutral 0.217 1K13 A A121V Disease Neutral 0.169 1K13 A H21R *Neutral Neutral 0.016 1K13 A R21H Neutral Neutral 0.192 1K13 A L22F Disease Disease 0.724 1K13 A C30R Disease Neutral 0.341 1K13 A F35L *Neutral Neutral 0.001 1K13 A L35F Neutral Neutral 0.433 1K13 A L94P Disease Disease 0.855 1K2A A H73Q Neutral Neutral 0.136 1K2A A Q73H *Neutral Neutral 0.490 1K2P A L408P Disease Disease 0.911 1K2P A G414R Disease Disease 0.916 1K2P A Y418H Disease Disease 0.533 1K2P A I429N Disease Disease 0.810 1K2P A K430E Disease Disease 0.935 1K2P A K430R Disease Disease 0.868 1K2P A E445D Disease Disease 0.881 1K2P A G462D Disease Disease 0.970 1K2P A G462V Disease Disease 0.951 1K2P A Y476D Disease Disease 0.823 1K2P A M477R Disease Disease 0.908 1K2P A C502F Disease Disease 0.855 1K2P A C502W Disease Disease 0.879 1K2P A C506R Disease Disease 0.842 1K2P A C506Y Disease Disease 0.864 1K2P A A508D Disease Disease 0.925 1K2P A M509I Disease Disease 0.925 1K2P A M509V Disease Disease 0.920 1K2P A L512P Disease Disease 0.914 1K2P A L512Q Disease Disease 0.804 1K2P A L518R Disease Disease 0.537 1K2P A R520Q Disease Disease 0.874 1K2P A D521G Disease Disease 0.810 1K2P A D521H Disease Disease 0.832 1K2P A D521N Disease Disease 0.872 1K2P A A523E Disease Disease 0.949 1K2P A R525G Disease Disease 0.890 1K2P A R525P Disease Disease 0.953 1K2P A R525Q Disease Disease 0.903 1K2P A N526K Disease Disease 0.934 1K2P A V535F Disease Disease 0.896 1K2P A L542P Disease Disease 0.871 1K2P A R544G Disease Disease 0.839 1K2P A R544K Disease Disease 0.763 1K2P A F559S Disease Disease 0.612 1K2P A R562P Disease Disease 0.948 1K2P A R562W Disease Disease 0.916 1K2P A W563L Disease Disease 0.928 1K2P A E567K Disease Disease 0.903 1K2P A S578Y Disease Disease 0.903 1K2P A W581R Disease Disease 0.937 1K2P A A582V Disease Disease 0.902 1K2P A F583S Disease Disease 0.931 1K2P A M587L Disease Neutral 0.081 1K2P A E589D Disease Disease 0.902 1K2P A E589G Disease Disease 0.825 1K2P A E589K Disease Disease 0.936 1K2P A S592P Disease Disease 0.946 1K2P A G594E Disease Disease 0.958 1K2P A G594R Disease Disease 0.928 1K2P A Y598C Disease Disease 0.855 1K2P A A607D Disease Disease 0.662 1K2P A G613D Disease Disease 0.881 1K2P A P619A Disease Disease 0.849 1K2P A P619S Disease Disease 0.890 1K2P A P619T Disease Disease 0.880 1K2P A A622P Disease Disease 0.906 1K2P A V626G Disease Disease 0.661 1K2P A I630M *Neutral Neutral 0.001 1K2P A M630I Neutral Disease 0.947 1K2P A M630K Disease Disease 0.968 1K2P A M630T Disease Disease 0.942 1K2P A C633Y Disease Disease 0.965 1K2P A R641C Disease Disease 0.962 1K2P A R641H Disease Disease 0.915 1K2P A F644L Disease Disease 0.919 1K2P A F644S Disease Disease 0.911 1K2P A L647P Disease Disease 0.901 1K2P A L652P Disease Disease 0.571 1K3Y A P113Q Neutral Neutral 0.118 1K3Y A Q113P *Neutral Neutral 0.055 1K3Y A K117Q Neutral Neutral 0.236 1K3Y A Q117K *Neutral Neutral 0.011 1K3Y A I19T *Neutral Disease 0.629 1K3Y A T19I Neutral Neutral 0.007 1K5D B A145V Neutral Neutral 0.106 1K5D B V145A *Neutral Neutral 0.050 1K94 A A80S *Neutral Neutral 0.137 1K94 A S80A Neutral Neutral 0.268 1K96 A H27R Neutral Neutral 0.292 1K96 A R27H *Neutral Neutral 0.154 1K96 A N69S Neutral Disease 0.583 1K96 A S69N *Neutral Neutral 0.234 1K96 A I83T Neutral Neutral 0.500 1K96 A T83I *Neutral Neutral 0.035 1K96 A D90G *Neutral Neutral 0.000 1K96 A G90D Neutral Disease 0.811 1KCQ A D187N Disease Disease 0.601 1KCQ A D187Y Disease Disease 0.520 1KDK A L156P *Neutral Neutral 0.002 1KDK A P156L Neutral Disease 0.691 1KFU S M924V Neutral Neutral 0.282 1KFU S V924M *Neutral Neutral 0.147 1KIV A M66T Neutral Neutral 0.006 1KIV A T66M *Neutral Neutral 0.195 1KLU B E10Q *Neutral Neutral 0.001 1KLU B Q10E Neutral Neutral 0.494 1KLU B D135G *Neutral Neutral 0.000 1KLU B G135D Neutral Neutral 0.075 1KLU B A140T Neutral Neutral 0.047 1KLU B T140A *Neutral Neutral 0.001 1KLU B M142V *Neutral Neutral 0.000 1KLU B V142M Neutral Neutral 0.240 1KLU B H149Q *Neutral Neutral 0.002 1KLU B Q149H Neutral Neutral 0.044 1KLU B Q166R *Neutral Neutral 0.008 1KLU B R166Q Neutral Neutral 0.005 1KLU B I181T *Neutral Neutral 0.002 1KLU B T181I Neutral Neutral 0.018 1KLU B S37Y Neutral Neutral 0.029 1KLU B Y37S *Neutral Disease 0.543 1KLU B K4R *Neutral Neutral 0.001 1KLU B Q4R *Neutral Neutral 0.001 1KLU B R4K Neutral Neutral 0.152 1KLU B R4Q Neutral Neutral 0.091 1KLU B G45R Neutral Disease 0.670 1KLU B R45G *Neutral Neutral 0.000 1KLU B F47Y *Neutral Neutral 0.015 1KLU B Y47F Neutral Neutral 0.028 1KLU B S60Y *Neutral Neutral 0.001 1KLU B Y60S Neutral Neutral 0.163 1KLU B I67L *Neutral Neutral 0.034 1KLU B L67I Neutral Neutral 0.008 1KLU B D70Q *Neutral Neutral 0.006 1KLU B E70Q *Neutral Neutral 0.005 1KLU B H70Q *Neutral Neutral 0.005 1KLU B Q70D Neutral Neutral 0.096 1KLU B Q70E Neutral Neutral 0.149 1KLU B Q70H Neutral Neutral 0.184 1KLU B A71R *Neutral Neutral 0.014 1KLU B E71R *Neutral Neutral 0.008 1KLU B R71A Neutral Neutral 0.134 1KLU B R71E Neutral Neutral 0.242 1KLU B A73G Neutral Neutral 0.263 1KLU B G73A *Neutral Neutral 0.001 1KLU B A74E Neutral Neutral 0.060 1KLU B E74A *Neutral Neutral 0.017 1KLU B N77T *Neutral Neutral 0.001 1KLU B T77N Neutral Neutral 0.395 1KLU B H78Y *Neutral Neutral 0.008 1KLU B Y78H Neutral Disease 0.518 1KLU B A85V *Neutral Neutral 0.001 1KLU B V85A Neutral Neutral 0.296 1KLU B G86V Neutral Neutral 0.092 1KLU B V86G *Neutral Neutral 0.008 1KO9 A G12E Disease Disease 0.890 1KO9 A R131Q Disease Disease 0.924 1KO9 A R154H Disease Disease 0.878 1KO9 A Q229R *Neutral Neutral 0.006 1KO9 A R229Q Neutral Disease 0.729 1KO9 A S232T Disease Neutral 0.313 1KO9 A A288V Neutral Neutral 0.442 1KO9 A V288A *Neutral Neutral 0.040 1KO9 A S320T Neutral Neutral 0.147 1KO9 A T320S *Neutral Neutral 0.315 1KO9 A D322N Neutral Disease 0.663 1KO9 A N322D *Neutral Neutral 0.007 1KO9 A R46Q Disease Disease 0.924 1KO9 A A85S Disease Neutral 0.182 1KPN A S214P Disease Neutral 0.318 1KPN A P264S Disease Disease 0.675 1KPN A G79R Disease Neutral 0.455 1KPW A C203R Disease Disease 0.808 1KPX A I111V Neutral Neutral 0.045 1KPX A V111I *Neutral Neutral 0.062 1KPX A S116Y Neutral Neutral 0.155 1KPX A Y116S *Neutral Neutral 0.195 1KPX A L153M Neutral Neutral 0.167 1KPX A M153L *Neutral Neutral 0.142 1KPX A A174V Neutral Neutral 0.186 1KPX A V174A *Neutral Neutral 0.014 1KPX A A180S *Neutral Neutral 0.044 1KPX A S180A Neutral Neutral 0.070 1KPX A C203R Disease Disease 0.810 1KPX A I230T Neutral Neutral 0.403 1KPX A T230I *Neutral Neutral 0.020 1KPX A I274V Neutral Neutral 0.007 1KPX A V274I *Neutral Neutral 0.074 1KPX A A298P Neutral Neutral 0.182 1KPX A P298A *Neutral Neutral 0.020 1KPX A P307L Disease Disease 0.631 1KPX A F309Y *Neutral Neutral 0.270 1KPX A Y309F Neutral Neutral 0.076 1KPX A I65T *Neutral Neutral 0.087 1KPX A T65I Neutral Neutral 0.027 1KRN A I142K *Neutral Neutral 0.149 1KRN A K142I Neutral Neutral 0.173 1KRN A R97W Neutral Neutral 0.380 1KRN A W97R *Neutral Neutral 0.064 1KW2 A D432E Neutral Neutral 0.120 1KW2 A E432D *Neutral Neutral 0.032 1KW2 A K436T Neutral Neutral 0.047 1KW2 A T436K *Neutral Neutral 0.078 1KW2 A C445R *Neutral Neutral 0.135 1KW2 A H445R *Neutral Neutral 0.116 1KW2 A R445C Neutral Disease 0.669 1KW2 A R445H Neutral Neutral 0.475 1KXU A K138R Neutral Neutral 0.228 1KXU A R138K *Neutral Neutral 0.041 1KXU A A270V *Neutral Neutral 0.016 1KXU A V270A Neutral Disease 0.883 1KXU A L28R *Neutral Neutral 0.146 1KXU A R28L Neutral Disease 0.718 1KXU A M54V Neutral Disease 0.675 1KXU A V54M *Neutral Neutral 0.387 1KZW A A54T Neutral Neutral 0.001 1KZW A T54A *Neutral Neutral 0.482 1L1F A S217C Disease Disease 0.966 1L1F A R221C Disease Disease 0.984 1L1F A R265K Disease Disease 0.802 1L1F A R265T Disease Disease 0.952 1L1F A Y266C Disease Disease 0.946 1L1F A R269C Disease Disease 0.944 1L1F A R269H Disease Disease 0.861 1L1F A E296A Disease Disease 0.656 1L1F A S445L Disease Disease 0.827 1L1F A G446D Disease Disease 0.956 1L1F A G446S Disease Disease 0.952 1L1F A S448P Disease Disease 0.970 1L1F A H454Y Disease Disease 0.934 1L8C B A119T *Neutral Neutral 0.000 1L8C B T119A Neutral Disease 0.837 1L9X A I127T *Neutral Neutral 0.027 1L9X A T127I Neutral Neutral 0.197 1L9X A A7T Neutral Neutral 0.290 1L9X A T7A *Neutral Neutral 0.001 1LBN A A160T Neutral Disease 0.534 1LBN A T160A *Neutral Neutral 0.007 1LBN A E176V *Neutral Neutral 0.020 1LBN A V176E Neutral Neutral 0.500 1LBN A I217V *Neutral Neutral 0.015 1LBN A V217I Neutral Neutral 0.023 1LDL A C25S Disease Disease 0.964 1LDL A A29S Disease Disease 0.775 1LDL A S35P Disease Disease 0.981 1LDR A R15C Disease Disease 0.979 1LDR A C26Y Disease Disease 0.960 1LDR A D27N Disease Disease 0.959 1LDR A Q29E Disease Disease 0.905 1LDR A C32G Disease Disease 0.953 1LEU A I110L *Neutral Neutral 0.361 1LEU A L110I Neutral Neutral 0.276 1LEU A I72S *Neutral Neutral 0.035 1LEU A S72I Neutral Neutral 0.451 1LEU A R89T Neutral Disease 0.683 1LEU A T89R *Neutral Neutral 0.010 1LFA A R189W Neutral Neutral 0.266 1LFA A W189R *Neutral Neutral 0.054 1LFN A I124T Neutral Disease 0.646 1LFN A T124I *Neutral Neutral 0.151 1LFN A H214R *Neutral Neutral 0.046 1LFN A R214H Neutral Neutral 0.195 1LFN A I226T *Neutral Neutral 0.054 1LFN A T226I Neutral Neutral 0.069 1LFN A M264T Neutral Neutral 0.113 1LFN A T264M *Neutral Neutral 0.059 1LFR A D225E *Neutral Neutral 0.010 1LFR A E225D Neutral Neutral 0.059 1LFS A A13T Neutral Neutral 0.371 1LFS A T13A *Neutral Neutral 0.004 1LG3 A A163G *Neutral Neutral 0.096 1LG3 A G163A Neutral Disease 0.585 1LG3 A M285T *Neutral Neutral 0.073 1LG3 A T285M Neutral Disease 0.891 1LG4 A L149S Neutral Disease 0.718 1LG4 A S149L *Neutral Neutral 0.000 1LG4 A L56P *Neutral Neutral 0.002 1LG4 A P56L Neutral Disease 0.741 1LG4 A F70L Neutral Disease 0.529 1LG4 A L70F *Neutral Neutral 0.001 1LH9 A P367T Neutral Disease 0.646 1LH9 A T367P *Neutral Neutral 0.004 1LI4 A Y143C Disease Disease 0.660 1LI4 A R38W Neutral Neutral 0.464 1LI4 A W38R *Neutral Neutral 0.038 1LI4 A R49C Disease Disease 0.906 1LI4 A D86G Disease Disease 0.660 1LI4 A D86N Neutral Disease 0.684 1LI4 A N86D *Neutral Neutral 0.000 1LI4 A A89V Disease Disease 0.754 1LJ5 A H186R *Neutral Neutral 0.099 1LJ5 A R186H Neutral Neutral 0.348 1LJ5 A H2P Neutral Disease 0.513 1LJ5 A P2H *Neutral Neutral 0.001 1LJ5 A N232T *Neutral Neutral 0.208 1LJ5 A T232N Neutral Neutral 0.230 1LJM B R2139Q Disease Disease 0.959 1LJR A E129K Neutral Neutral 0.178 1LJR A K129E *Neutral Neutral 0.015 1LJR A I139M *Neutral Neutral 0.104 1LJR A M139I Neutral Neutral 0.135 1LKK A G201S Neutral Neutral 0.066 1LKK A S201G *Neutral Disease 0.576 1LM8 V L101G Disease Disease 0.869 1LM8 V L101R Disease Disease 0.858 1LM8 V T105P Disease Disease 0.915 1LM8 V G106D Disease Disease 0.845 1LM8 V R107G Disease Disease 0.867 1LM8 V R107P Disease Disease 0.955 1LM8 V H110Y Neutral Disease 0.514 1LM8 V Y110H *Neutral Neutral 0.028 1LM8 V S111C Disease Disease 0.933 1LM8 V S111N Disease Disease 0.908 1LM8 V S111R Disease Disease 0.859 1LM8 V Y112H Disease Disease 0.902 1LM8 V Y112N Disease Disease 0.908 1LM8 V G114C Disease Disease 0.953 1LM8 V G114R Disease Disease 0.935 1LM8 V G114S Disease Disease 0.829 1LM8 V H115Q Disease Disease 0.943 1LM8 V H115R Disease Disease 0.958 1LM8 V H115Y Disease Disease 0.967 1LM8 V L116V Disease Disease 0.890 1LM8 V W117C Disease Disease 0.950 1LM8 V L118P Disease Disease 0.953 1LM8 V L118R Disease Disease 0.884 1LM8 V F119L Disease Disease 0.936 1LM8 V F119S Disease Disease 0.940 1LM8 V D121G Disease Disease 0.910 1LM8 V A122I Disease Disease 0.903 1LM8 V D126Y Disease Disease 0.944 1LM8 V L128F Disease Disease 0.949 1LM8 V V130L Disease Disease 0.913 1LM8 V N131K Disease Disease 0.897 1LM8 V N131T Disease Disease 0.808 1LM8 V F136C Disease Disease 0.932 1LM8 V F136S Disease Disease 0.922 1LM8 V F136Y Disease Disease 0.619 1LM8 V D143E Disease Neutral 0.443 1LM8 V Q145H Disease Disease 0.769 1LM8 V I147T Disease Disease 0.615 1LM8 V A149T Disease Disease 0.830 1LM8 V P154L Disease Disease 0.892 1LM8 V V155G Disease Disease 0.761 1LM8 V V155M Disease Disease 0.587 1LM8 V Y156C Disease Disease 0.932 1LM8 V Y156D Disease Disease 0.919 1LM8 V Y156N Disease Disease 0.924 1LM8 V T157I Disease Disease 0.760 1LM8 V L158P Disease Disease 0.940 1LM8 V L158V Disease Disease 0.885 1LM8 V K159E Disease Disease 0.795 1LM8 V R161G Disease Disease 0.915 1LM8 V R161P Disease Disease 0.960 1LM8 V R161Q Disease Disease 0.894 1LM8 V C162F Disease Disease 0.872 1LM8 V C162R Disease Disease 0.849 1LM8 V C162W Disease Disease 0.822 1LM8 V C162Y Disease Disease 0.878 1LM8 V L163P Disease Disease 0.970 1LM8 V Q164H Disease Disease 0.930 1LM8 V Q164R Disease Disease 0.815 1LM8 V V166D Disease Disease 0.898 1LM8 V V166F Disease Disease 0.882 1LM8 V R167G Disease Disease 0.939 1LM8 V R167Q Disease Disease 0.927 1LM8 V R167W Disease Disease 0.925 1LM8 V V170D Disease Disease 0.908 1LM8 V V170F Disease Disease 0.901 1LM8 V V170G Disease Disease 0.885 1LM8 V Y175D Disease Disease 0.925 1LM8 V R176W Disease Disease 0.889 1LM8 V L178P Disease Disease 0.970 1LM8 V L178Q Disease Disease 0.931 1LM8 V I180V Disease Disease 0.855 1LM8 V L184P Disease Disease 0.961 1LM8 V L184R Disease Disease 0.911 1LM8 V E186K Disease Disease 0.921 1LM8 V L188P Disease Disease 0.966 1LM8 V L188Q Disease Disease 0.912 1LM8 V L188V Disease Disease 0.922 1LM8 V H191D Disease Disease 0.747 1LM8 V P192S Disease Disease 0.894 1LM8 V L198Q Disease Disease 0.875 1LM8 V L198R Disease Disease 0.888 1LM8 V R200W Disease Disease 0.870 1LM8 V L63P Disease Disease 0.969 1LM8 V R64P Disease Disease 0.970 1LM8 V S65A Disease Disease 0.916 1LM8 V S65L Disease Disease 0.909 1LM8 V S65W Disease Disease 0.893 1LM8 V S68W Disease Disease 0.880 1LM8 V E70K Disease Disease 0.916 1LM8 V V74G Disease Disease 0.908 1LM8 V F76I Disease Disease 0.872 1LM8 V F76L Disease Disease 0.912 1LM8 V F76S Disease Disease 0.925 1LM8 V N78H Disease Disease 0.911 1LM8 V N78S Disease Disease 0.940 1LM8 V N78T Disease Disease 0.921 1LM8 V R79P Disease Disease 0.954 1LM8 V S80I Disease Disease 0.860 1LM8 V S80N Disease Disease 0.911 1LM8 V S80R Disease Disease 0.859 1LM8 V P81S Disease Disease 0.759 1LM8 V R82P Disease Disease 0.967 1LM8 V V84L Disease Disease 0.922 1LM8 V P86A Disease Disease 0.887 1LM8 V P86H Disease Disease 0.913 1LM8 V P86L Disease Disease 0.897 1LM8 V P86R Disease Disease 0.910 1LM8 V P86S Disease Disease 0.927 1LM8 V W88R Disease Disease 0.921 1LM8 V W88S Disease Disease 0.949 1LM8 V L89H Disease Disease 0.893 1LM8 V L89P Disease Disease 0.963 1LM8 V G93C Disease Disease 0.950 1LM8 V G93D Disease Disease 0.935 1LM8 V G93S Disease Disease 0.928 1LM8 V Q96P Disease Disease 0.943 1LM8 V Y98H Disease Disease 0.895 1LMJ A C20W Disease Disease 0.920 1LMJ A Y35C Disease Disease 0.951 1LMJ A D47G Neutral Disease 0.935 1LMJ A D47V Disease Disease 0.922 1LMJ A G47D *Neutral Neutral 0.001 1LMJ A C51G Disease Disease 0.924 1LMJ A C51Y Disease Disease 0.931 1LMJ A D6G Disease Disease 0.860 1LMJ A C63Y Disease Disease 0.960 1LMJ A N65Y Disease Disease 0.940 1LMJ A E7K Disease Disease 0.939 1LMJ A R71P Disease Disease 0.936 1LMJ A C8R Disease Disease 0.939 1LMJ A A82P *Neutral Neutral 0.058 1LMJ A P82A Neutral Neutral 0.385 1LMJ A C87S Disease Disease 0.955 1LMJ A C87Y Disease Disease 0.947 1LN1 A A10E *Neutral Neutral 0.001 1LN1 A E10A Neutral Disease 0.640 1LRB A K206R *Neutral Neutral 0.001 1LRB A R206K Neutral Disease 0.618 1LRB A D207N Neutral Neutral 0.024 1LRB A N207D *Neutral Neutral 0.028 1LRE A N80S Neutral Neutral 0.305 1LRE A S80N *Neutral Neutral 0.001 1LRX B A399D Disease Disease 0.879 1LRX B L401V Disease Disease 0.905 1LRX B F403L Disease Disease 0.834 1LRX B L414R Disease Disease 0.901 1LRX B R416Q Disease Neutral 0.387 1LRX B R416W Disease Neutral 0.426 1LRX B I423T Disease Disease 0.734 1LRX B L432V Disease Disease 0.768 1LRX B I468V *Neutral Neutral 0.035 1LRX B V468I Neutral Neutral 0.305 1LRX B D482H Disease Disease 0.934 1LRX B W483R Disease Disease 0.921 1LRX B N564H Disease Disease 0.926 1LRX B L568V Disease Disease 0.645 1LRX B P608S Disease Disease 0.926 1LRX B R633C Disease Disease 0.927 1LRX B P649L Disease Disease 0.688 1LS7 A D57N Neutral Neutral 0.111 1LS7 A N57D *Neutral Neutral 0.000 1LSL A A505T *Neutral Neutral 0.421 1LSL A T505A Neutral Neutral 0.083 1LU6 A R311Q Disease Disease 0.709 1LU6 A C329Y Disease Disease 0.997 1LU6 A M341R Disease Disease 0.791 1LU6 A C354G Disease Disease 0.992 1LU6 A C354Y Disease Disease 0.996 1LU6 A C359G Disease Disease 0.995 1LU6 A C359Y Disease Disease 0.997 1LU6 A R365C Disease Disease 0.987 1LU6 A R365H Disease Disease 0.960 1LU6 A R365L Disease Disease 0.984 1LU6 A Q368P Disease Disease 0.986 1LU6 A H372Q Disease Disease 0.993 1LU6 A H372Y Disease Disease 0.996 1LU6 A H376R Disease Disease 0.996 1LU6 A H376Y Disease Disease 0.997 1LU6 A F382L Disease Disease 0.990 1LU6 A C384R Disease Disease 0.994 1LU6 A C387F Disease Disease 0.995 1LU6 A C387Y Disease Disease 0.996 1LU6 A F391L Disease Disease 0.994 1LU6 A R393L Disease Disease 0.992 1LU6 A R393P Disease Disease 0.995 1LU6 A R393Q Disease Disease 0.891 1LU6 A R393W Disease Disease 0.991 1LU6 A D395G Disease Disease 0.955 1LU6 A D395N Disease Disease 0.975 1LU6 A D395Y Disease Disease 0.976 1LU6 A L397P Disease Disease 0.997 1LU6 A H400Y Disease Disease 0.997 1LU6 A H404R Disease Disease 0.995 1LU7 A R105H Disease Disease 0.545 1LU7 A V88A Disease Disease 0.874 1LUG A H107Y Disease Disease 0.902 1LUG A G144R Disease Disease 0.808 1LUG A D252N *Neutral Neutral 0.017 1LUG A N252D Neutral Neutral 0.028 1LUG A Q92P Disease Disease 0.908 1LUG A H94Y Disease Disease 0.831 1LUT A C131R Disease Disease 0.639 1LUV A R132W Neutral Disease 0.838 1LUV A W132R *Neutral Disease 0.570 1LUV A E42V Neutral Disease 0.746 1LUV A V42E *Neutral Neutral 0.411 1LUV A G52R Neutral Disease 0.943 1LUV A R52G *Neutral Neutral 0.145 1LUV A I58T Neutral Disease 0.761 1LUV A T58I *Neutral Neutral 0.218 1LXU A Q39R *Neutral Neutral 0.003 1LXU A R39Q Neutral Neutral 0.426 1LXV A Q84R *Neutral Neutral 0.010 1LXV A R84Q Neutral Neutral 0.081 1LYA B F165I Disease Disease 0.890 1LYA B G218R Neutral Neutral 0.293 1LYA B R218G *Neutral Neutral 0.043 1LYA B W319C Disease Disease 0.917 1M4K A F45Y *Neutral Neutral 0.086 1M4K A Y45F Neutral Neutral 0.084 1M4R A G158S *Neutral Neutral 0.000 1M4R A S158G Neutral Disease 0.579 1M6O A D116Y Neutral Neutral 0.048 1M6O A Y116D *Neutral Neutral 0.494 1M6O A D156L Neutral Neutral 0.222 1M6O A D156R Neutral Neutral 0.129 1M6O A L156D *Neutral Neutral 0.250 1M6O A R156D *Neutral Neutral 0.454 1M6O A L163T Neutral Neutral 0.015 1M6O A T163L *Neutral Neutral 0.281 1M6O A A41T *Neutral Neutral 0.097 1M6O A T41A Neutral Neutral 0.003 1M6O A D61E Neutral Neutral 0.012 1M6O A E61D *Neutral Neutral 0.012 1M6O A E63N Neutral Neutral 0.173 1M6O A N63E *Neutral Neutral 0.016 1M6O A N77S Neutral Neutral 0.336 1M6O A S77N *Neutral Neutral 0.009 1M6Q A S286T *Neutral Neutral 0.000 1M6Q A T286S Neutral Neutral 0.436 1M6Q A G323R Disease Disease 0.528 1M6Q A T372P Disease Neutral 0.276 1M6Q A D386V Disease Neutral 0.194 1M6Q A G407R Disease Disease 0.615 1M6Q A V432E Disease Neutral 0.180 1M6Q A A434E Disease Disease 0.563 1M6Q A A436T Disease Neutral 0.395 1M6Q A A436V Disease Neutral 0.412 1M6Q A A443V Disease Neutral 0.041 1M6Q A R444C Disease Disease 0.545 1M6Q A R444H Disease Neutral 0.354 1M6Q A R444L Disease Neutral 0.353 1M6Q A R444S Disease Neutral 0.213 1M6Q A T445P Disease Neutral 0.152 1M6Q A V451E Disease Neutral 0.157 1M6Q A V451M Disease Neutral 0.062 1M6Q A E452Q *Neutral Neutral 0.212 1M6Q A Q452E Neutral Neutral 0.291 1M6Q A F455S Disease Disease 0.634 1M6Q A M458V *Neutral Neutral 0.207 1M6Q A V458M Neutral Neutral 0.108 1M6Q A L459P Disease Disease 0.686 1M6Q A L459R Disease Neutral 0.437 1M6Q A P467R Disease Neutral 0.273 1M6Q A G471E Disease Disease 0.787 1M6Q A P476R Disease Disease 0.714 1M6Q A P476S Disease Disease 0.753 1M7M A R101L Disease Disease 0.987 1M7M A R101Q Disease Disease 0.980 1M7M A R101W Disease Disease 0.981 1M7M A L107P Disease Disease 0.977 1M7M A V129M Disease Disease 0.947 1M7M A G140E Disease Disease 0.970 1M7M A R142Q Disease Disease 0.621 1M7M A R149Q Disease Disease 0.946 1M7M A R149W Disease Disease 0.970 1M7M A H15D Disease Disease 0.987 1M7M A L152M Disease Disease 0.841 1M7M A R156C Disease Disease 0.994 1M7M A R156H Disease Disease 0.987 1M7M A V177M Disease Disease 0.927 1M7M A A179D Disease Disease 0.972 1M7M A Q199P Disease Disease 0.846 1M7M A G20R Disease Disease 0.980 1M7M A R211C Disease Disease 0.944 1M7M A R211H Disease Disease 0.919 1M7M A A215T Disease Disease 0.980 1M7M A G216R Disease Disease 0.992 1M7M A T233I Disease Disease 0.737 1M7M A P274L Disease Disease 0.703 1M7M A S291L Disease Disease 0.935 1M7M A P297Q Disease Disease 0.924 1M7M A L304R Disease Disease 0.932 1M7M A A329V Disease Disease 0.902 1M7M A G74C Disease Disease 0.931 1M7M A R76W Disease Disease 0.893 1M7M A D8N Neutral Disease 0.510 1M7M A N8D *Neutral Neutral 0.014 1M7M A K80R Neutral Disease 0.563 1M7M A R80K *Neutral Disease 0.918 1M7M A A83D Disease Disease 0.978 1M8A A M21V *Neutral Neutral 0.002 1M8A A V21M Neutral Neutral 0.095 1M8O B S57P Disease Disease 0.814 1M92 A G122S Neutral Neutral 0.451 1M92 A S122G *Neutral Neutral 0.043 1M92 A I15M *Neutral Neutral 0.011 1M92 A M15I Neutral Neutral 0.404 1M92 A A18T Neutral Disease 0.534 1M92 A T18A *Neutral Neutral 0.012 1M92 A R28W *Neutral Disease 0.635 1M92 A W28R Neutral Neutral 0.341 1M92 A I35T Neutral Neutral 0.001 1M92 A T35I *Neutral Disease 0.741 1M92 A Q74R Disease Disease 0.933 1MFX A G112E Disease Disease 0.855 1MFX A M142T *Neutral Neutral 0.269 1MFX A T142M Neutral Neutral 0.229 1MFX A R362C Disease Disease 0.905 1MFX A R362S Disease Disease 0.862 1MFX A R372Q Disease Disease 0.794 1MFX A R441Q Disease Disease 0.894 1MFX A R441W Disease Disease 0.903 1MFX A R446C Disease Disease 0.818 1MHL C R403W Disease Disease 0.825 1MHL C C438R *Neutral Neutral 0.115 1MHL C R438C Neutral Disease 0.787 1MHL C E517Q Neutral Neutral 0.336 1MHL C Q517E *Neutral Neutral 0.071 1MHL C I551V Neutral Neutral 0.035 1MHL C V551I *Neutral Neutral 0.224 1MHN A A111G Disease Disease 0.842 1MHN A I116F Disease Disease 0.668 1MHN A Q136E Disease Disease 0.818 1MHN A G95R Disease Disease 0.706 1MMQ A D142G *Neutral Neutral 0.215 1MMQ A G142D Neutral Neutral 0.454 1MMQ A L245P *Neutral Neutral 0.015 1MMQ A P245L Neutral Neutral 0.350 1MOI A H360P Neutral Disease 0.591 1MOI A P360H *Neutral Neutral 0.028 1MOI A R54W Neutral Neutral 0.480 1MOI A W54R *Neutral Neutral 0.000 1MOI A Q71R Neutral Neutral 0.099 1MOI A R71Q *Neutral Neutral 0.303 1MOX B P242R Neutral Neutral 0.478 1MOX B R242P *Neutral Neutral 0.045 1MOX B K497R *Neutral Neutral 0.154 1MOX B R497K Neutral Disease 0.667 1MOX B Q74R *Neutral Neutral 0.111 1MOX B R74Q Neutral Neutral 0.478 1MPU A N177S Neutral Neutral 0.008 1MPU A S177N *Neutral Neutral 0.008 1N3H A A95V Neutral Disease 0.559 1N3H A V95A *Neutral Neutral 0.001 1N3Y A F182L Neutral Disease 0.829 1N3Y A L182F *Neutral Neutral 0.001 1N3Y A A232T Neutral Neutral 0.184 1N3Y A T232A *Neutral Neutral 0.183 1N45 A L106P *Neutral Neutral 0.252 1N45 A P106L Neutral Disease 0.743 1N5U A A191T Neutral Neutral 0.431 1N5U A A191V Neutral Neutral 0.397 1N5U A T191A *Neutral Neutral 0.112 1N5U A V191A *Neutral Neutral 0.142 1N5U A L196Q *Neutral Neutral 0.036 1N5U A Q196L Neutral Disease 0.705 1N5U A R218H Disease Disease 0.758 1N5U A R218P Disease Disease 0.914 1N5U A E396K Neutral Neutral 0.180 1N5U A K396E *Neutral Neutral 0.038 1N5U A E466K *Neutral Neutral 0.018 1N5U A K466E Neutral Neutral 0.224 1N5U A F49Y Neutral Neutral 0.403 1N5U A Y49F *Neutral Neutral 0.151 1N5U A L66P Disease Disease 0.715 1N5U A E97G Neutral Disease 0.727 1N5U A G97E *Neutral Neutral 0.002 1NAX A D216G Neutral Neutral 0.172 1NAX A G216D *Neutral Neutral 0.017 1NAX A A234T Disease Disease 0.615 1NAX A R243W Disease Disease 0.814 1NAX A A268G Disease Disease 0.522 1NAX A R316H Disease Disease 0.929 1NAX A A317T Disease Disease 0.586 1NAX A R320C Disease Disease 0.951 1NAX A R320H Disease Disease 0.919 1NAX A N331D Disease Disease 0.514 1NAX A G332R Disease Disease 0.890 1NAX A A335P Disease Disease 0.700 1NAX A I337T *Neutral Neutral 0.034 1NAX A T337I Neutral Neutral 0.458 1NAX A R338W Disease Disease 0.850 1NAX A Q340H Disease Disease 0.784 1NAX A L341P Disease Disease 0.893 1NAX A K342I Disease Disease 0.536 1NAX A G345R Disease Disease 0.920 1NAX A G345S Disease Disease 0.865 1NAX A G345V Disease Disease 0.897 1NAX A L346F Disease Neutral 0.159 1NAX A G347E Disease Disease 0.874 1NAX A V348E Disease Neutral 0.111 1NAX A T426I Disease Disease 0.561 1NAX A R429Q Disease Disease 0.904 1NAX A I431M Disease Disease 0.750 1NAX A R438H Disease Disease 0.762 1NAX A M442V Disease Disease 0.684 1NAX A K443E Disease Disease 0.791 1NAX A C446R Disease Disease 0.565 1NAX A P447T Disease Disease 0.643 1NAX A P453H Disease Disease 0.677 1NAX A P453L Disease Disease 0.654 1NAX A P453S Disease Disease 0.752 1NAX A P453T Disease Disease 0.691 1NAX A F459C Disease Disease 0.806 1NB5 I M123T *Neutral Neutral 0.006 1NB5 I T123M Neutral Disease 0.617 1NBN B I114V *Neutral Neutral 0.000 1NBN B V114I Neutral Neutral 0.178 1NBN B A133D *Neutral Neutral 0.012 1NBN B D133A Neutral Neutral 0.031 1NBN B D133G Neutral Neutral 0.000 1NBN B G133D *Neutral Neutral 0.064 1NBN B A138T Neutral Neutral 0.078 1NBN B T138A *Neutral Neutral 0.000 1NBN B D160E *Neutral Neutral 0.000 1NBN B E160D Neutral Neutral 0.325 1NBN B L163P *Neutral Neutral 0.000 1NBN B P163L Neutral Neutral 0.189 1NBN B I183T *Neutral Neutral 0.003 1NBN B T183I Neutral Neutral 0.045 1ND6 B F1091V Neutral Disease 0.734 1ND6 B V1091F *Neutral Neutral 0.014 1ND6 B R1193W *Neutral Neutral 0.001 1ND6 B W1193R Neutral Disease 0.663 1ND6 B H1297Y *Neutral Neutral 0.051 1ND6 B Y1297H Neutral Disease 0.603 1ND6 B A1327V *Neutral Neutral 0.056 1ND6 B V1327A Neutral Neutral 0.348 1ND8 A I12L Neutral Neutral 0.009 1ND8 A L12I *Neutral Neutral 0.006 1ND8 A C20S Neutral Neutral 0.101 1ND8 A S20C *Neutral Neutral 0.000 1ND8 A L215S *Neutral Neutral 0.012 1ND8 A S215L Neutral Neutral 0.087 1ND8 A Q223R *Neutral Neutral 0.005 1ND8 A R223Q Neutral Neutral 0.086 1ND8 A A29S Neutral Neutral 0.013 1ND8 A S29A *Neutral Neutral 0.003 1ND8 A G301V Neutral Neutral 0.180 1ND8 A V301G *Neutral Neutral 0.000 1ND8 A A335V Neutral Neutral 0.033 1ND8 A V335A *Neutral Neutral 0.005 1ND8 A F339Y *Neutral Neutral 0.002 1ND8 A Y339F Neutral Neutral 0.022 1ND8 A F42I *Neutral Neutral 0.015 1ND8 A I42F Neutral Neutral 0.060 1ND8 A L55Q Neutral Neutral 0.087 1ND8 A Q55L *Neutral Neutral 0.004 1ND8 A R60S Neutral Neutral 0.116 1ND8 A S60R *Neutral Neutral 0.009 1ND8 A A73V Neutral Neutral 0.256 1ND8 A V73A *Neutral Neutral 0.000 1NG2 A S160T *Neutral Neutral 0.013 1NG2 A T160S Neutral Neutral 0.295 1NG2 A D166N Neutral Neutral 0.044 1NG2 A N166D *Neutral Neutral 0.007 1NG2 A E258K *Neutral Neutral 0.000 1NG2 A K258E Neutral Disease 0.812 1NG2 A G262S Neutral Disease 0.817 1NG2 A S262G *Neutral Neutral 0.000 1NG2 A A308V Neutral Disease 0.648 1NG2 A V308A *Neutral Neutral 0.000 1NI2 A C180R *Neutral Neutral 0.001 1NI2 A R180C Neutral Disease 0.623 1NI6 C D7H Neutral Disease 0.635 1NI6 C H7D *Neutral Neutral 0.005 1NKR A L114P *Neutral Neutral 0.001 1NKR A P114L Neutral Disease 0.586 1NKR A P154T Neutral Neutral 0.123 1NKR A T154P *Neutral Neutral 0.048 1NKR A P16R Neutral Disease 0.665 1NKR A R16P *Neutral Neutral 0.023 1NKR A D163N Neutral Neutral 0.059 1NKR A N163D *Neutral Neutral 0.038 1NKR A H182R Neutral Neutral 0.021 1NKR A R182H *Neutral Neutral 0.081 1NKR A F45Y Neutral Neutral 0.149 1NKR A Y45F *Neutral Neutral 0.076 1NKR A L90V *Neutral Neutral 0.408 1NKR A V90L Neutral Neutral 0.061 1NQL B D11E Neutral Disease 0.754 1NQL B E11D *Neutral Neutral 0.000 1NR4 E M44V *Neutral Neutral 0.000 1NR4 E V44M Neutral Neutral 0.298 1NRG A Q116R *Neutral Neutral 0.002 1NRG A R116Q Neutral Neutral 0.384 1NRG A R229W Disease Disease 0.882 1NRG A E50K Neutral Disease 0.726 1NRG A K50E *Neutral Neutral 0.000 1NUN A C106F Disease Neutral 0.165 1NUN A I156R Disease Neutral 0.090 1O02 A E320V Neutral Neutral 0.492 1O02 A V320E *Neutral Neutral 0.010 1O02 A E479K Neutral Neutral 0.108 1O02 A K479E *Neutral Neutral 0.115 1O02 A E487K Neutral Disease 0.626 1O02 A K487E *Neutral Neutral 0.028 1O1U A H32R *Neutral Neutral 0.051 1O1U A R32H Neutral Disease 0.677 1O1U A S54Y Neutral Disease 0.555 1O1U A Y54S *Neutral Neutral 0.254 1O1U A M78T *Neutral Neutral 0.374 1O1U A T78M Neutral Neutral 0.347 1O43 A F32L *Neutral Neutral 0.003 1O43 A L32F Neutral Disease 0.930 1O43 A A93T Neutral Disease 0.712 1O43 A T93A *Neutral Neutral 0.003 1OEA A I248L Neutral Neutral 0.040 1OEA A L248I *Neutral Neutral 0.002 1OEA A K266M *Neutral Neutral 0.018 1OEA A M266K Neutral Neutral 0.087 1OHC A I302T Neutral Disease 0.610 1OHC A T302I *Neutral Neutral 0.004 1OHC A I341T Neutral Disease 0.811 1OHC A T341I *Neutral Neutral 0.000 1OIZ A H101Q Disease Disease 0.521 1OIZ A A120T Disease Neutral 0.390 1OIZ A E141K Disease Disease 0.755 1OIZ A S172T *Neutral Neutral 0.033 1OIZ A T172S Neutral Neutral 0.079 1OIZ A R192H Disease Neutral 0.347 1OIZ A R221W Disease Disease 0.693 1OIZ A G246R Disease Disease 0.781 1OIZ A R59W Disease Disease 0.653 1OJW B L20R *Neutral Neutral 0.032 1OJW B R20L Neutral Neutral 0.169 1OLG A K321E Disease Disease 0.841 1OLG A G325V Disease Disease 0.907 1OLG A R337C Disease Disease 0.974 1OLG A R337H Disease Disease 0.951 1OLG A L344P Disease Disease 0.962 1OLG A A360G *Neutral Neutral 0.000 1OLG A G360A Neutral Disease 0.906 1OLL A K58Q Neutral Neutral 0.087 1OLL A Q58K *Neutral Neutral 0.092 1OP8 A M109T *Neutral Neutral 0.116 1OP8 A T109M Neutral Neutral 0.076 1OVC A N121S Disease Neutral 0.265 1OVC A E178K Disease Disease 0.926 1OVC A L19P Disease Disease 0.900 1OVC A L32S Neutral Disease 0.817 1OVC A S32L *Neutral Neutral 0.007 1OW0 A D295E *Neutral Neutral 0.004 1OW0 A E295D Neutral Disease 0.600 1OW0 C D92N Neutral Neutral 0.500 1OW0 C N92D *Neutral Neutral 0.001 1OW3 A C172R *Neutral Neutral 0.005 1OW3 A R172C Neutral Neutral 0.383 1OWA A F109S *Neutral Neutral 0.164 1OWA A S109F Neutral Neutral 0.345 1OWA A G151D Disease Disease 0.866 1OWA A D152N Neutral Neutral 0.235 1OWA A N152D *Neutral Neutral 0.079 1OWA A I24S Disease Disease 0.658 1OWA A R28C Disease Disease 0.825 1OWA A R28H Disease Disease 0.750 1OWA A R28L Disease Disease 0.582 1OWA A R28S Disease Disease 0.742 1OWA A V31A Disease Disease 0.649 1OWA A R34W Disease Disease 0.875 1OWA A R41W Disease Neutral 0.500 1OWA A R45S Disease Disease 0.836 1OWA A R45T Disease Disease 0.818 1OWA A G46V Disease Disease 0.531 1OWA A K48R Disease Neutral 0.212 1OWA A L49F Disease Disease 0.810 1OZ2 A I479M Neutral Disease 0.758 1OZ2 A M479I *Neutral Neutral 0.459 1OZ5 A A199S *Neutral Neutral 0.010 1OZ5 A S199A Neutral Neutral 0.079 1OZ5 A P37T *Neutral Neutral 0.001 1OZ5 A R37T *Neutral Neutral 0.003 1OZ5 A T37P Neutral Disease 0.633 1OZ5 A T37R Neutral Neutral 0.420 1OZ5 A R50S Neutral Neutral 0.474 1OZ5 A S50R *Neutral Neutral 0.037 1P2W A A11V Neutral Neutral 0.274 1P2W A V11A *Neutral Neutral 0.002 1P2W A N61T Neutral Neutral 0.276 1P2W A T61N *Neutral Neutral 0.082 1P5F A A104T Disease Disease 0.841 1P5F A D149A Disease Disease 0.620 1P5F A G150S Neutral Disease 0.581 1P5F A S150G *Neutral Neutral 0.001 1P5F A E163K Neutral Disease 0.571 1P5F A K163E *Neutral Neutral 0.007 1P5F A L166P Disease Disease 0.916 1P5F A A171S Neutral Neutral 0.207 1P5F A S171A *Neutral Neutral 0.039 1P5F A M26I Disease Disease 0.800 1P5F A E64D Disease Neutral 0.071 1P5F A Q98R *Neutral Neutral 0.047 1P5F A R98Q Neutral Neutral 0.122 1P7X A L72M Neutral Neutral 0.217 1P7X A M72L *Neutral Neutral 0.000 1P7X A L90Q *Neutral Neutral 0.000 1P7X A Q90L Neutral Disease 0.784 1PCU A A136P Disease Disease 0.567 1PCU A P168L Disease Neutral 0.293 1PCU A R169W Disease Neutral 0.306 1PEX A D385G Neutral Neutral 0.044 1PEX A G385D *Neutral Neutral 0.019 1PKX B S116T *Neutral Neutral 0.060 1PKX B T116S Neutral Neutral 0.320 1PKX B K426R Disease Disease 0.713 1PQ3 A G240R Neutral Neutral 0.390 1PQ3 A R240G *Neutral Neutral 0.064 1PUB A C107R Disease Disease 0.861 1PUB A R138P Disease Disease 0.922 1PUB A I28V Neutral Neutral 0.063 1PUB A V28I *Neutral Neutral 0.114 1PUB A M38V Neutral Neutral 0.082 1PUB A V38M *Neutral Neutral 0.141 1PUV A E297V *Neutral Neutral 0.077 1PUV A V297E Neutral Disease 0.955 1PUV A H317N Neutral Neutral 0.241 1PUV A N317H *Neutral Neutral 0.320 1PUV A A99P *Neutral Neutral 0.008 1PUV A P99A Neutral Disease 0.892 1PWB A S270T Neutral Neutral 0.085 1PWB A T270S *Neutral Neutral 0.017 1PWB A E289K Neutral Neutral 0.020 1PWB A K289E *Neutral Neutral 0.044 1PWI A Q100R Neutral Neutral 0.156 1PWI A R100Q *Neutral Neutral 0.071 1PWI A G82S Neutral Neutral 0.490 1PWI A S82G *Neutral Neutral 0.007 1PY5 A T200I Disease Disease 0.908 1PY5 A K232E Disease Disease 0.985 1PY5 A S241L Disease Disease 0.924 1PY5 A C291Y *Neutral Neutral 0.344 1PY5 A Y291C Neutral Disease 0.967 1PY5 A M318R Disease Disease 0.868 1PY5 A D400G Disease Disease 0.959 1PY5 A R487P Disease Disease 0.946 1PY5 A R487Q Disease Disease 0.723 1PY5 A R487W Disease Disease 0.915 1PYO C A13P *Neutral Neutral 0.005 1PYO C P13A Neutral Disease 0.513 1Q7L A N179S Neutral Neutral 0.033 1Q7L A S179N *Neutral Neutral 0.088 1Q7L A R197W Disease Disease 0.807 1QB0 A E534K Neutral Neutral 0.285 1QB0 A K534E *Neutral Neutral 0.003 1QIP B A110E *Neutral Neutral 0.010 1QIP B E110A Neutral Neutral 0.122 1QIP B C18Y Neutral Neutral 0.120 1QIP B Y18C *Neutral Neutral 0.246 1QLP A H101R *Neutral Neutral 0.041 1QLP A R101H Neutral Neutral 0.076 1QLP A G115S Neutral Disease 0.664 1QLP A S115G *Neutral Neutral 0.080 1QLP A A213V *Neutral Neutral 0.078 1QLP A V213A Neutral Neutral 0.045 1QLP A E264V Neutral Disease 0.639 1QLP A V264E *Neutral Neutral 0.003 1QLP A A336T Neutral Disease 0.512 1QLP A T336A *Neutral Neutral 0.003 1QLP A D376E *Neutral Neutral 0.149 1QLP A E376D Neutral Neutral 0.071 1QO5 A R133S Neutral Disease 0.980 1QO5 A S133R *Neutral Neutral 0.001 1QO5 A C134R Disease Disease 0.944 1QO5 A A149P Disease Disease 0.969 1QO5 A A174D Disease Disease 0.984 1QO5 A C177R Disease Disease 0.978 1QO5 A P184R Disease Disease 0.974 1QO5 A E206Q Neutral Disease 0.859 1QO5 A Q206E *Neutral Neutral 0.009 1QO5 A V221F Disease Disease 0.957 1QO5 A L228P Disease Disease 0.992 1QO5 A L256P Disease Disease 0.989 1QO5 A I267N Neutral Disease 0.972 1QO5 A N267I *Neutral Neutral 0.012 1QO5 A L283P Disease Disease 0.985 1QO5 A R303Q Disease Disease 0.964 1QO5 A R303W Disease Disease 0.966 1QO5 A N334K Disease Disease 0.973 1QO5 A A337V Disease Disease 0.952 1QO5 A I73T Disease Disease 0.939 1QQD A A11S *Neutral Neutral 0.460 1QQD A S11A Neutral Neutral 0.002 1QQD A R14W *Neutral Disease 0.549 1QQD A W14R Neutral Neutral 0.001 1QQD A L156R *Neutral Neutral 0.059 1QQD A R156L Neutral Neutral 0.293 1QQD A A158V Neutral Neutral 0.401 1QQD A V158A *Neutral Neutral 0.004 1QQD A G16S Neutral Neutral 0.439 1QQD A S16G *Neutral Neutral 0.000 1QQD A E177K Neutral Neutral 0.185 1QQD A K177E *Neutral Neutral 0.002 1QQD A H21R *Neutral Neutral 0.002 1QQD A R21H Neutral Disease 0.589 1QQD A M248V *Neutral Neutral 0.004 1QQD A V248M Neutral Neutral 0.265 1QQD A L28V *Neutral Neutral 0.000 1QQD A V28L Neutral Disease 0.505 1QQD A A49E *Neutral Disease 0.706 1QQD A E49A Neutral Neutral 0.001 1QQD A M52V *Neutral Neutral 0.148 1QQD A V52M Neutral Neutral 0.011 1QQD A K66N Neutral Neutral 0.030 1QQD A N66K *Neutral Neutral 0.088 1QQD A A73T Neutral Neutral 0.013 1QQD A T73A *Neutral Neutral 0.136 1QQD A S9Y Neutral Neutral 0.009 1QQD A Y9S *Neutral Neutral 0.283 1QRP E K160Q *Neutral Neutral 0.032 1QRP E Q160K Neutral Neutral 0.117 1QRP E A203T Neutral Neutral 0.206 1QRP E T203A *Neutral Neutral 0.118 1QRP E L291V Neutral Neutral 0.073 1QRP E V291L *Neutral Neutral 0.062 1QRP E D314E Neutral Disease 0.821 1QRP E E314D *Neutral Neutral 0.000 1QTN A R248W Disease Disease 0.707 1QTN A D285H Neutral Neutral 0.487 1QTN A H285D *Neutral Neutral 0.327 1QWT A E377K Neutral Disease 0.938 1QWT A K377E *Neutral Neutral 0.002 1QWT A S427T Neutral Neutral 0.028 1QWT A T427S *Neutral Neutral 0.005 1QZJ A E583K Disease Disease 0.823 1QZJ A F584C Disease Disease 0.679 1QZJ A F584L Disease Disease 0.509 1QZJ A G601R Disease Disease 0.815 1QZJ A L656P Disease Disease 0.813 1QZJ A G664R Disease Neutral 0.351 1QZJ A C691S Neutral Neutral 0.116 1QZJ A S691C *Neutral Neutral 0.004 1QZJ A N715S *Neutral Neutral 0.013 1QZJ A S715N Neutral Neutral 0.210 1QZJ A R791G Disease Disease 0.667 1QZJ A R796G Disease Disease 0.748 1QZJ A G812V Disease Disease 0.893 1QZJ A D816V Disease Neutral 0.456 1QZJ A D816Y Disease Disease 0.558 1QZJ A T847P Disease Disease 0.676 1R3A A D113N Disease Neutral 0.080 1R3A A H114L Disease Neutral 0.155 1R3A A F117S Disease Neutral 0.366 1R3A A Q118H Disease Neutral 0.164 1R3A A R123G Disease Disease 0.552 1R3A A R123Q Disease Neutral 0.314 1R3A A V125A Disease Neutral 0.214 1R3A A K127E Disease Neutral 0.031 1R3A A M129T Disease Disease 0.563 1R3A A C130Y Disease Disease 0.823 1R3A A H132Y Disease Disease 0.642 1R3A A S135L Disease Disease 0.541 1R3A A S135W Disease Disease 0.592 1R3A A T138M Disease Disease 0.528 1R3A A L139P Disease Disease 0.923 1R3A A M142K Disease Disease 0.852 1R3A A M142V Disease Disease 0.723 1R3A A S143L Disease Neutral 0.400 1R3A A R148G Disease Disease 0.570 1R3A A R148Q Disease Disease 0.544 1R3A A R148W Disease Disease 0.693 1R3A A V150L Disease Disease 0.652 1R3A A V151A Disease Disease 0.684 1R3A A W154G Disease Disease 0.855 1R3A A W167R Disease Disease 0.585 1R3A A F171S Disease Disease 0.933 1R3A A G179D Disease Disease 0.797 1R3A A P183T Disease Neutral 0.271 1R3A A H184Q Disease Disease 0.724 1R3A A Q188R Disease Disease 0.940 1R3A A S192N Disease Neutral 0.391 1R3A A F194L Disease Neutral 0.373 1R3A A L195P Disease Disease 0.803 1R3A A I198M Disease Neutral 0.149 1R3A A I198T Disease Neutral 0.143 1R3A A A199T Disease Neutral 0.383 1R3A A R201H Disease Neutral 0.371 1R3A A E203K Disease Neutral 0.439 1R3A A R204P Disease Neutral 0.467 1R3A A Y209C Disease Disease 0.680 1R3A A Y209S Disease Disease 0.578 1R3A A Q212H Disease Neutral 0.139 1R3A A L217P Disease Disease 0.852 1R3A A L226P Disease Disease 0.675 1R3A A K229N Disease Neutral 0.248 1R3A A R231H Disease Disease 0.877 1R3A A W249R Disease Disease 0.786 1R3A A Y251C Disease Disease 0.772 1R3A A Y251S Disease Disease 0.701 1R3A A Q252H Disease Disease 0.736 1R3A A R258C Disease Disease 0.604 1R3A A R259W Disease Disease 0.608 1R3A A R262P Disease Neutral 0.500 1R3A A R272G Disease Disease 0.634 1R3A A D28Y Disease Disease 0.599 1R3A A L282V Disease Neutral 0.260 1R3A A K285N Disease Neutral 0.500 1R3A A L289R Disease Disease 0.788 1R3A A E291K Disease Neutral 0.397 1R3A A F294Y Disease Disease 0.824 1R3A A E308K Disease Neutral 0.410 1R3A A D314N *Neutral Neutral 0.187 1R3A A N314D Neutral Neutral 0.063 1R3A A Q317H Disease Neutral 0.181 1R3A A Q317R Disease Neutral 0.500 1R3A A H319Q Disease Disease 0.718 1R3A A I32N Disease Neutral 0.485 1R3A A A320T Disease Disease 0.612 1R3A A Y323D Disease Disease 0.837 1R3A A Y323H Disease Disease 0.723 1R3A A P324S Disease Disease 0.869 1R3A A P325L Disease Disease 0.764 1R3A A R328H Disease Disease 0.853 1R3A A S329F Disease Disease 0.705 1R3A A A330V Disease Disease 0.728 1R3A A R333G Disease Disease 0.719 1R3A A R333Q Disease Disease 0.643 1R3A A R333W Disease Disease 0.738 1R3A A K334R Disease Disease 0.724 1R3A A M336L Disease Neutral 0.149 1R3A A Q344K Disease Disease 0.579 1R3A A T350A Disease Disease 0.771 1R3A A Q38P Disease Disease 0.687 1R3A A V44L Disease Disease 0.712 1R3A A V44M Disease Disease 0.627 1R3A A S45L Disease Disease 0.715 1R3A A R51L Disease Disease 0.868 1R3A A R51Q Disease Disease 0.824 1R3A A G55C Disease Disease 0.799 1R3A A L62M Neutral Neutral 0.064 1R3A A M62L *Neutral Neutral 0.021 1R3A A R67C Disease Neutral 0.384 1R3A A L74P Disease Disease 0.935 1R3A A A81T Disease Neutral 0.207 1R3A A N97S Disease Disease 0.825 1R3A A D98N Disease Disease 0.674 1R3Q A V134Q Disease Disease 0.902 1R3Q A R142Q Disease Disease 0.856 1R3Q A R144P Disease Disease 0.772 1R3Q A G156D Disease Disease 0.956 1R3Q A L161Q Disease Disease 0.889 1R3Q A M165R Disease Disease 0.928 1R3Q A E167K Disease Disease 0.957 1R3Q A R193P Disease Disease 0.759 1R3Q A L195F Disease Disease 0.775 1R3Q A L216Q Disease Disease 0.669 1R3Q A E218K Disease Disease 0.836 1R3Q A S219F Disease Disease 0.879 1R3Q A H220P Disease Disease 0.929 1R3Q A F229L Disease Disease 0.841 1R3Q A F232L Disease Disease 0.893 1R3Q A P235S Disease Disease 0.624 1R3Q A G25E Disease Disease 0.898 1R3Q A L253Q Disease Neutral 0.492 1R3Q A I260T Disease Disease 0.528 1R3Q A G281E Disease Disease 0.957 1R3Q A G281V Disease Disease 0.924 1R3Q A L282R Disease Disease 0.909 1R3Q A R292G Disease Disease 0.865 1R3Q A G303S Disease Disease 0.946 1R3Q A N304K Disease Disease 0.939 1R3Q A Y311C Disease Disease 0.866 1R3Q A G318R Disease Neutral 0.091 1R3Q A M324T Disease Disease 0.632 1R3Q A R332H Disease Disease 0.770 1R3Q A I334T Disease Disease 0.886 1R3Q A F46L Disease Disease 0.858 1R3Q A P62L Disease Disease 0.891 1R3Q A A80G Disease Disease 0.749 1R3Q A A80S Disease Disease 0.933 1R42 A K26R Neutral Neutral 0.002 1R42 A R26K *Neutral Neutral 0.001 1R4C A L68Q Disease Neutral 0.351 1RFN A I103F Disease Disease 0.828 1RFN A L105R Disease Disease 0.807 1RFN A L108Q Disease Disease 0.729 1RFN A P120H Disease Disease 0.689 1RFN A P120T Disease Disease 0.613 1RFN A T129K Disease Neutral 0.460 1RFN A T129M Disease Neutral 0.303 1RFN A I129BL Disease Neutral 0.059 1RFN A G136D Disease Disease 0.724 1RFN A W141C Disease Disease 0.900 1RFN A G142E Disease Disease 0.957 1RFN A G142R Disease Disease 0.929 1RFN A K148E Disease Neutral 0.083 1RFN A G149W Disease Disease 0.566 1RFN A A152D Disease Disease 0.642 1RFN A V16D Disease Disease 0.833 1RFN A V16F Disease Disease 0.807 1RFN A R165G Disease Neutral 0.354 1RFN A R165Q Disease Neutral 0.164 1RFN A C168Y Disease Disease 0.877 1RFN A L169F Disease Neutral 0.245 1RFN A L169I Disease Neutral 0.165 1RFN A V17F Disease Disease 0.813 1RFN A V17L Disease Disease 0.795 1RFN A K173E Disease Neutral 0.030 1RFN A I176F Disease Disease 0.512 1RFN A M180K Disease Disease 0.863 1RFN A F181I Disease Neutral 0.204 1RFN A F181L Disease Neutral 0.157 1RFN A C182F Disease Disease 0.904 1RFN A C182S Disease Disease 0.899 1RFN A A183P Disease Disease 0.933 1RFN A R188AT Disease Disease 0.554 1RFN A C191R Disease Disease 0.832 1RFN A C191S Disease Disease 0.820 1RFN A D194H Disease Disease 0.826 1RFN A S195G Disease Disease 0.816 1RFN A S195I Disease Disease 0.919 1RFN A G196E Disease Disease 0.969 1RFN A G197R Disease Disease 0.914 1RFN A P198T Disease Disease 0.891 1RFN A V203E Disease Neutral 0.066 1RFN A F208V Disease Neutral 0.141 1RFN A T210P Disease Disease 0.522 1RFN A S214T Disease Disease 0.832 1RFN A W215G Disease Disease 0.685 1RFN A W215R Disease Disease 0.752 1RFN A G216S Disease Disease 0.824 1RFN A G216V Disease Disease 0.817 1RFN A E217A Disease Neutral 0.288 1RFN A E217K Disease Neutral 0.417 1RFN A C220Y Disease Disease 0.874 1RFN A A221V Disease Disease 0.772 1RFN A G226E Disease Disease 0.935 1RFN A G226R Disease Disease 0.902 1RFN A I227T Disease Disease 0.631 1RFN A R233Q Disease Neutral 0.215 1RFN A R233W Disease Neutral 0.339 1RFN A Y234C Disease Disease 0.770 1RFN A W237R Disease Disease 0.760 1RFN A I238T Disease Disease 0.626 1RFN A P245T *Neutral Neutral 0.000 1RFN A T245P Neutral Neutral 0.284 1RFN A Q30H Disease Disease 0.848 1RFN A Q30K Disease Disease 0.925 1RFN A C42S Disease Disease 0.896 1RFN A C42Y Disease Disease 0.923 1RFN A G43E Disease Disease 0.962 1RFN A G43R Disease Disease 0.940 1RFN A A55T Disease Disease 0.872 1RFN A C58W Disease Disease 0.845 1RFN A A68T Disease Disease 0.513 1RFN A N72D Disease Neutral 0.085 1RFN A E80V Disease Neutral 0.340 1RFN A R83G Disease Neutral 0.426 1RFN A R83Q Disease Neutral 0.468 1RFN A H91R Disease Disease 0.879 1RFN A N95S Disease Neutral 0.185 1RG6 A I10T Disease Disease 0.959 1RG6 A L14F Disease Disease 0.991 1RG6 A S21A Disease Disease 0.908 1RG6 A C22G Disease Disease 0.985 1RG6 A S41P Disease Disease 0.990 1RG6 A D64H Neutral Disease 0.975 1RG6 A H64D *Neutral Neutral 0.038 1RJ7 E H252L Disease Disease 0.791 1RJ7 E H252Y Disease Disease 0.816 1RJ7 E G255C Disease Disease 0.864 1RJ7 E G255D Disease Disease 0.812 1RJ7 E G269V Disease Disease 0.840 1RJ7 E W274G Disease Disease 0.759 1RJ7 E G291R Disease Disease 0.848 1RJ7 E G291W Disease Disease 0.831 1RJ7 E D298H Disease Disease 0.700 1RJ7 E D298Y Disease Disease 0.742 1RJ7 E G299S Disease Disease 0.821 1RJ7 E F302S Disease Disease 0.801 1RJ7 E Q306H Disease Disease 0.844 1RJ7 E V307G Disease Disease 0.808 1RJ7 E Y320C Disease Disease 0.868 1RJ7 E C332Y Disease Disease 0.843 1RJ7 E Y343C Disease Disease 0.568 1RJ7 E A349T Disease Disease 0.726 1RJ7 E A356D Disease Disease 0.719 1RJ7 E R357P Disease Disease 0.665 1RJ7 E Q358E Disease Disease 0.815 1RJ7 E I360N Disease Disease 0.789 1RJ7 E N372D Disease Disease 0.659 1RJ7 E M373I Disease Disease 0.791 1RJ7 E S374R Disease Disease 0.646 1RJ7 E T378M Disease Disease 0.669 1RJ7 E T378P Disease Disease 0.921 1RJT A N34S Neutral Neutral 0.404 1RJT A S34N *Neutral Neutral 0.002 1RKC A L234V *Neutral Neutral 0.122 1RKC A V234L Neutral Disease 0.575 1ROZ A D174E *Neutral Neutral 0.083 1ROZ A E174D Neutral Neutral 0.015 1RW6 A E482K Neutral Disease 0.949 1RW6 A K482E *Neutral Neutral 0.002 1RX0 A M106I Disease Disease 0.701 1RX0 A D112Y Disease Disease 0.787 1RX0 A G115R Disease Disease 0.959 1RX0 A M130T Disease Disease 0.905 1RX0 A V181I Disease Disease 0.914 1RX0 A R280Q Disease Disease 0.937 1RX0 A A298T Disease Disease 0.856 1RX0 A R312C Disease Disease 0.945 1RX0 A Q363R Disease Disease 0.855 1RY0 A H5Q *Neutral Neutral 0.000 1RY0 A Q5H Neutral Neutral 0.244 1RY7 A E21G *Neutral Neutral 0.000 1RY7 A G21E Neutral Disease 0.753 1RY7 B R248C Disease Disease 0.756 1RY7 B S249C Disease Disease 0.687 1RY7 B P250R Disease Disease 0.593 1RY7 B E322K Disease Disease 0.599 1RY7 B M338T *Neutral Neutral 0.040 1RY7 B T338M Neutral Disease 0.789 1RYO A G123S Neutral Disease 0.840 1RYO A S123G *Neutral Neutral 0.004 1RYO A L23R *Neutral Neutral 0.046 1RYO A R23L Neutral Disease 0.611 1RYO A G258S Neutral Neutral 0.469 1RYO A S258G *Neutral Neutral 0.036 1RYO A D277G Neutral Neutral 0.040 1RYO A G277D *Neutral Neutral 0.005 1RYO A H300R Neutral Neutral 0.144 1RYO A R300H *Neutral Neutral 0.277 1RYO A R36S *Neutral Neutral 0.140 1RYO A S36R Neutral Neutral 0.151 1RYO A A57V Neutral Disease 0.841 1RYO A V57A *Neutral Neutral 0.001 1RYO A D58N Disease Disease 0.906 1S1P A C170R *Neutral Neutral 0.038 1S1P A R170C Neutral Neutral 0.192 1S1P A I175M *Neutral Neutral 0.060 1S1P A M175I Neutral Neutral 0.178 1S1P A P180S Neutral Neutral 0.068 1S1P A S180P *Neutral Neutral 0.020 1S1P A Q66R *Neutral Neutral 0.030 1S1P A R66Q Neutral Neutral 0.415 1S9K E M307T *Neutral Neutral 0.002 1S9K E T307M Neutral Disease 0.700 1S9V A I104T Neutral Neutral 0.002 1S9V A T104I *Neutral Neutral 0.053 1S9V A H126Q Neutral Neutral 0.007 1S9V A Q126H *Neutral Neutral 0.029 1S9V A F15S *Neutral Neutral 0.000 1S9V A S15F Neutral Neutral 0.258 1S9V A F22Y *Neutral Neutral 0.005 1S9V A Y22F Neutral Neutral 0.117 1S9V A S23T *Neutral Neutral 0.002 1S9V A T23S Neutral Neutral 0.411 1S9V A E31Q *Neutral Neutral 0.050 1S9V A Q31E Neutral Neutral 0.050 1S9V A K38R *Neutral Neutral 0.055 1S9V A R38K Neutral Neutral 0.000 1S9V A C44Y Neutral Neutral 0.130 1S9V A Y44C *Neutral Neutral 0.234 1S9V A D47V *Neutral Neutral 0.032 1S9V A L47V *Neutral Neutral 0.021 1S9V A V47D Neutral Neutral 0.033 1S9V A V47L Neutral Neutral 0.061 1S9V A R52S Neutral Neutral 0.002 1S9V A S52R *Neutral Neutral 0.017 1S9V A R61T *Neutral Neutral 0.115 1S9V A T61R Neutral Neutral 0.008 1S9V A I63M Neutral Neutral 0.256 1S9V A M63I *Neutral Neutral 0.001 1S9V A L66V Neutral Neutral 0.089 1S9V A V66L *Neutral Neutral 0.075 1S9V A S77Y Neutral Neutral 0.204 1S9V A Y77S *Neutral Neutral 0.001 1SG0 A K15R Neutral Neutral 0.009 1SG0 A R15K *Neutral Neutral 0.060 1SG0 A A183V *Neutral Neutral 0.007 1SG0 A V183A Neutral Disease 0.708 1SG0 A E28G Neutral Neutral 0.203 1SG0 A G28E *Neutral Neutral 0.141 1SG0 A F46L Neutral Disease 0.819 1SG0 A L46F *Neutral Neutral 0.002 1SG0 A D57G *Neutral Neutral 0.001 1SG0 A G57D Neutral Neutral 0.208 1SHR B I4T *Neutral Neutral 0.002 1SHR B T4I Neutral Neutral 0.400 1SHU X G105D Disease Disease 0.782 1SHU X I189T Disease Disease 0.844 1SHU X C218R Disease Disease 0.769 1SHU X L45P Disease Disease 0.912 1SIQ A V104I Disease Disease 0.532 1SIQ A R117Q Disease Neutral 0.456 1SIQ A G134R Disease Disease 0.850 1SIQ A L135R Disease Disease 0.810 1SIQ A M147T Disease Disease 0.580 1SIQ A A151T Disease Disease 0.794 1SIQ A R183P Disease Disease 0.929 1SIQ A F192L Disease Disease 0.784 1SIQ A R213Q Disease Disease 0.694 1SIQ A R213W Disease Disease 0.736 1SIQ A M222V Disease Disease 0.730 1SIQ A P234S Disease Neutral 0.364 1SIQ A L239P Disease Disease 0.667 1SIQ A A249T Disease Disease 0.583 1SIQ A R250W Disease Disease 0.886 1SIQ A Y251H Disease Disease 0.632 1SIQ A A254T Neutral Disease 0.901 1SIQ A A254V Neutral Disease 0.894 1SIQ A T254A *Neutral Neutral 0.003 1SIQ A V254A *Neutral Neutral 0.006 1SIQ A S261L Disease Disease 0.750 1SIQ A C264S Disease Disease 0.617 1SIQ A L265W Disease Disease 0.599 1SIQ A R269W Disease Disease 0.580 1SIQ A Q289E Disease Disease 0.734 1SIQ A A305T Disease Neutral 0.341 1SIQ A G310R Disease Disease 0.760 1SIQ A G310S Disease Disease 0.606 1SIQ A R311C Disease Disease 0.711 1SIQ A R311H Disease Neutral 0.469 1SIQ A E321K Disease Neutral 0.135 1SIQ A C331R Disease Disease 0.634 1SIQ A A338T Disease Disease 0.569 1SIQ A R339C Disease Disease 0.742 1SIQ A R339H Disease Neutral 0.447 1SIQ A R342Q Disease Disease 0.739 1SIQ A G346A Disease Disease 0.822 1SIQ A G346R Disease Disease 0.872 1SIQ A N348D Disease Disease 0.653 1SIQ A V356M Disease Disease 0.634 1SIQ A R358Q Disease Disease 0.874 1SIQ A R358W Disease Disease 0.896 1SIQ A H359R Disease Disease 0.762 1SIQ A N362K Disease Disease 0.710 1SIQ A L363P Disease Disease 0.774 1SIQ A E370K Disease Disease 0.812 1SIQ A T372I Disease Disease 0.759 1SIQ A A377T Disease Disease 0.500 1SIQ A A377V Disease Disease 0.604 1SIQ A T385M Disease Neutral 0.441 1SIQ A A389E Disease Disease 0.701 1SIQ A R44C Disease Disease 0.747 1SIQ A R50L Disease Disease 0.640 1SIQ A G57R Disease Disease 0.836 1SIQ A C71Y Disease Disease 0.867 1SIQ A A78V Disease Disease 0.713 1SIQ A R84G Disease Disease 0.667 1SIQ A R94G Disease Neutral 0.091 1SIQ A S95L Disease Neutral 0.157 1SL4 A A382S Neutral Neutral 0.017 1SL4 A S382A *Neutral Neutral 0.008 1SMO A S25T *Neutral Neutral 0.005 1SMO A T25S Neutral Neutral 0.290 1SNZ B N190Y Neutral Neutral 0.158 1SNZ B Y190N *Neutral Neutral 0.294 1SR7 B L865S *Neutral Neutral 0.174 1SR7 B S865L Neutral Disease 0.524 1SX9 A F12L Disease Disease 0.823 1SX9 A F12S Disease Disease 0.867 1SX9 A A19V Disease Disease 0.692 1SX9 A W43R Disease Disease 0.797 1SX9 A R52P Disease Disease 0.803 1SX9 A F54L Disease Disease 0.832 1SX9 A A58T Disease Disease 0.809 1SX9 A H65Y Disease Disease 0.868 1SX9 A P70R Disease Disease 0.734 1SX9 A P8L Disease Disease 0.766 1T0L A R132C Disease Disease 0.969 1T0L A R132G Disease Disease 0.957 1T0L A R132H Disease Disease 0.947 1T0L A R132L Disease Disease 0.958 1T0L A R132S Disease Disease 0.955 1T0L A I178V *Neutral Neutral 0.001 1T0L A V178I Neutral Neutral 0.467 1T15 A I1652M *Neutral Neutral 0.350 1T15 A M1652I Neutral Disease 0.972 1T15 A C1662F *Neutral Neutral 0.454 1T15 A F1662C Neutral Disease 0.978 1T15 A M1665V *Neutral Neutral 0.084 1T15 A V1665M Neutral Disease 0.982 1T15 A D1692N Disease Disease 0.968 1T15 A C1697R Disease Disease 0.995 1T15 A R1699W Disease Disease 0.992 1T15 A A1708E Disease Disease 0.996 1T15 A G1713V *Neutral Neutral 0.187 1T15 A V1713G Neutral Disease 0.994 1T15 A P1749R Disease Disease 0.987 1T15 A M1775R Disease Disease 0.986 1T15 A P1776S Disease Disease 0.912 1T15 A L1786P Disease Disease 0.997 1T15 A P1812S Disease Disease 0.966 1T3N A I236M Neutral Disease 0.626 1T3N A M236I *Neutral Neutral 0.078 1T3N A E251K Neutral Neutral 0.432 1T3N A K251E *Neutral Neutral 0.187 1T3N A G71R *Neutral Neutral 0.001 1T3N A R71G Neutral Disease 0.926 1T78 A R256Q Disease Neutral 0.353 1T78 A R265W Disease Neutral 0.119 1T78 A E330G Neutral Neutral 0.044 1T78 A G330E *Neutral Neutral 0.016 1TE6 B A263P *Neutral Neutral 0.022 1TE6 B P263A Neutral Neutral 0.197 1TE6 B A394T *Neutral Neutral 0.001 1TE6 B T394A Neutral Disease 0.857 1TEN A D850H Neutral Neutral 0.225 1TEN A H850D *Neutral Neutral 0.206 1TKI A H127Q *Neutral Neutral 0.026 1TKI A Q127H Neutral Disease 0.918 1TKI A H169R *Neutral Neutral 0.167 1TKI A R169H Neutral Disease 0.750 1TKI A I94V *Neutral Neutral 0.358 1TKI A V94I Neutral Disease 0.505 1TN3 A G85S *Neutral Neutral 0.291 1TN3 A S85G Neutral Neutral 0.259 1TNM A M48V *Neutral Neutral 0.028 1TNM A V48M Neutral Disease 0.557 1TNM A K80Q Neutral Neutral 0.413 1TNM A Q80K *Neutral Neutral 0.002 1TNR A P91T *Neutral Neutral 0.058 1TNR A T91P Neutral Neutral 0.171 1TTA A G6S Neutral Neutral 0.049 1TTA A S6G *Neutral Neutral 0.007 1TU6 A G146R Disease Disease 0.829 1TU6 A A277V Disease Disease 0.862 1TU6 A L309P Disease Disease 0.850 1TXQ A G59S Disease Disease 0.926 1TYE B Y115C Disease Disease 0.888 1TYE B L117W Disease Disease 0.900 1TYE B D119N Disease Disease 0.837 1TYE B D119Y Disease Disease 0.833 1TYE B M124V Disease Disease 0.791 1TYE B Q143R *Neutral Neutral 0.040 1TYE B R143Q Neutral Neutral 0.125 1TYE B S162L Disease Neutral 0.097 1TYE B L196P Disease Disease 0.953 1TYE B R214Q Disease Disease 0.793 1TYE B R214W Disease Disease 0.818 1TYE B R216Q Disease Neutral 0.494 1TYE B D217V Disease Disease 0.843 1TYE B L262P Disease Disease 0.926 1TYE B H280P Disease Disease 0.569 1TYE B M295L Disease Neutral 0.006 1TYE B I304N Disease Disease 0.810 1TYE B L33P Neutral Neutral 0.226 1TYE B P33L *Neutral Neutral 0.028 1TYE B C374Y Disease Disease 0.884 1TYE B L40R Neutral Disease 0.507 1TYE B R40L *Neutral Neutral 0.121 1TYE B I427V *Neutral Neutral 0.005 1TYE B V427I Neutral Neutral 0.190 1TYE B R93W Disease Disease 0.861 1U1Q A N73S Neutral Neutral 0.247 1U1Q A S73N *Neutral Neutral 0.031 1U3U A C369R *Neutral Neutral 0.001 1U3U A R369C Neutral Disease 0.858 1U3U A H47R *Neutral Neutral 0.436 1U3U A R47H Neutral Neutral 0.002 1U3U A K56N *Neutral Neutral 0.199 1U3U A N56K Neutral Neutral 0.227 1U3U A S59T *Neutral Neutral 0.113 1U3U A T59S Neutral Neutral 0.150 1U8F O A22G Neutral Disease 0.851 1U8F O G22A *Neutral Neutral 0.029 1U8F O K251N Neutral Disease 0.619 1U8F O N251K *Neutral Neutral 0.002 1UC1 A H2L Neutral Neutral 0.045 1UC1 A L2H *Neutral Neutral 0.014 1UC1 A F75S Disease Neutral 0.296 1UJ3 C I713V Neutral Disease 0.537 1UJ3 C V713I *Neutral Neutral 0.001 1UJ3 C R731W Neutral Neutral 0.315 1UJ3 C W731R *Neutral Neutral 0.004 1UJL A R13C Disease Disease 0.961 1UJL A G15S Disease Disease 0.940 1UJL A W16C Disease Disease 0.956 1UJL A N19D Disease Disease 0.927 1UJL A N19K Disease Disease 0.957 1UJL A I24R Disease Disease 0.906 1UJL A I24T Disease Disease 0.900 1UJL A G3C Disease Disease 0.937 1UJL A G3R Disease Disease 0.921 1UJL A G32S Disease Disease 0.903 1UJL A G35S Disease Disease 0.935 1UJL A D40N Disease Disease 0.912 1UJL A Y42H Disease Disease 0.859 1UMK A V105M Disease Neutral 0.180 1UMK A S116T *Neutral Neutral 0.023 1UMK A T116S Neutral Neutral 0.045 1UMK A S127P Disease Disease 0.881 1UMK A L148P Disease Disease 0.771 1UMK A A178V Disease Disease 0.716 1UMK A C203R Disease Disease 0.524 1UMK A C203Y Disease Disease 0.512 1UMK A G291D Disease Disease 0.640 1UMK A R57Q Disease Neutral 0.492 1UMK A P65S *Neutral Neutral 0.008 1UMK A S65P Neutral Neutral 0.490 1UMK A L72P Disease Disease 0.861 1UNP A E17K Disease Disease 0.986 1UPE A H300R *Neutral Neutral 0.025 1UPE A R300H Neutral Neutral 0.265 1UPE A A50V Neutral Neutral 0.022 1UPE A V50A *Neutral Neutral 0.287 1UVQ A I107T *Neutral Neutral 0.002 1UVQ A T107I Neutral Neutral 0.074 1UVQ A C11Y Neutral Neutral 0.000 1UVQ A Y11C *Neutral Neutral 0.470 1UVQ A H129Q *Neutral Neutral 0.003 1UVQ A Q129H Neutral Neutral 0.049 1UVQ A F18S Neutral Neutral 0.001 1UVQ A S18F *Neutral Neutral 0.164 1UVQ A D2G Neutral Neutral 0.341 1UVQ A G2D *Neutral Neutral 0.000 1UVQ A F25Y *Neutral Neutral 0.006 1UVQ A Y25F Neutral Neutral 0.120 1UVQ A S26T *Neutral Neutral 0.003 1UVQ A T26S Neutral Neutral 0.371 1UVQ A E34Q *Neutral Neutral 0.031 1UVQ A Q34E Neutral Neutral 0.033 1UVQ A K41R *Neutral Neutral 0.066 1UVQ A R41K Neutral Neutral 0.001 1UVQ A Q47R *Neutral Neutral 0.002 1UVQ A R47Q Neutral Neutral 0.470 1UVQ A S80Y *Neutral Neutral 0.055 1UVQ A Y80S Neutral Neutral 0.001 1UX3 A Q143R *Neutral Neutral 0.124 1UX3 A R143Q Neutral Disease 0.586 1UX3 A L156S *Neutral Neutral 0.011 1UX3 A S156L Neutral Neutral 0.419 1UX3 A D168E *Neutral Neutral 0.007 1UX3 A E168D Neutral Neutral 0.414 1UX3 A L238S Neutral Neutral 0.400 1UX3 A S238L *Neutral Neutral 0.007 1UX3 A I316M Neutral Neutral 0.309 1UX3 A M316I *Neutral Neutral 0.056 1UX3 A A320V Neutral Disease 0.885 1UX3 A V320A *Neutral Neutral 0.001 1UX3 A N375S Neutral Neutral 0.365 1UX3 A S375N *Neutral Neutral 0.059 1UZJ A C1513R Disease Disease 0.916 1UZJ A R1530C Disease Disease 0.872 1UZJ A C1564F Disease Disease 0.951 1UZJ A C1564Y Disease Disease 0.959 1UZJ A M1576T Disease Neutral 0.400 1UZJ A C1589F Disease Disease 0.941 1UZJ A C1610G Disease Disease 0.894 1UZJ A C1631G Disease Disease 0.927 1V0X A H228R *Neutral Neutral 0.098 1V0X A R228H Neutral Neutral 0.020 1V0X A A428P *Neutral Neutral 0.070 1V0X A P428A Neutral Neutral 0.076 1V0X A E488G Neutral Disease 0.757 1V0X A G488E *Neutral Neutral 0.003 1V0X A A511V *Neutral Neutral 0.292 1V0X A V511A Neutral Neutral 0.316 1V0X A G587R Neutral Neutral 0.043 1V0X A R587G *Neutral Neutral 0.007 1V7M V E95G *Neutral Neutral 0.000 1V7M V G95E Neutral Disease 0.882 1VZP A L257R *Neutral Neutral 0.408 1VZP A R257L Neutral Neutral 0.052 1VZP A P304T Neutral Disease 0.897 1VZP A T304P *Neutral Neutral 0.003 1W6J A Q175R *Neutral Neutral 0.008 1W6J A R175Q Neutral Disease 0.749 1W6J A H310R Neutral Neutral 0.033 1W6J A R310H *Neutral Neutral 0.282 1W6J A R614W Neutral Disease 0.740 1W6J A W614R *Neutral Neutral 0.020 1W6J A L642V Neutral Neutral 0.067 1W6J A V642L *Neutral Neutral 0.065 1W6J A L688P *Neutral Neutral 0.008 1W6J A P688L Neutral Neutral 0.485 1WB0 A G102S Neutral Neutral 0.116 1WB0 A S102G *Neutral Neutral 0.012 1WB0 A H171Q *Neutral Neutral 0.025 1WB0 A Q171H Neutral Neutral 0.081 1WB0 A H40R *Neutral Neutral 0.085 1WB0 A R40H Neutral Neutral 0.270 1WBS A D343G Neutral Neutral 0.127 1WBS A G343D *Neutral Neutral 0.096 1WCH A I2458V Neutral Neutral 0.041 1WCH A V2458I *Neutral Neutral 0.025 1WCP A M284V Neutral Neutral 0.136 1WCP A V284M *Neutral Neutral 0.029 1WIO A F202S Neutral Neutral 0.437 1WIO A S202F *Neutral Neutral 0.000 1WIO A R240W Neutral Neutral 0.349 1WIO A W240R *Neutral Neutral 0.031 1WM2 A D16N Neutral Neutral 0.412 1WM2 A N16D *Neutral Neutral 0.010 1WMA A P130S Neutral Neutral 0.076 1WMA A S130P *Neutral Neutral 0.062 1WMA A I87V *Neutral Neutral 0.004 1WMA A V87I Neutral Neutral 0.105 1WQJ B G21V *Neutral Neutral 0.008 1WQJ B V21G Neutral Neutral 0.354 1WSR A N117I Disease Disease 0.877 1WSR A H14R Disease Disease 0.919 1WSR A E183K Disease Disease 0.500 1WSR A G19R Disease Disease 0.783 1WSR A G241D Disease Disease 0.931 1WSR A D248H Disease Disease 0.847 1WSR A R292H Disease Disease 0.845 1WWB X G309R Neutral Disease 0.741 1WWB X R309G *Neutral Neutral 0.000 1WWB X N338Y Neutral Neutral 0.380 1WWB X Y338N *Neutral Neutral 0.004 1WYW A G199S Neutral Neutral 0.254 1WYW A S199G *Neutral Neutral 0.024 1X79 B E640G Neutral Disease 0.599 1X79 B G640E *Neutral Neutral 0.000 1X7Q A G107W Neutral Disease 0.765 1X7Q A W107G *Neutral Neutral 0.001 1X7Q A F109L Neutral Neutral 0.005 1X7Q A L109F *Neutral Neutral 0.204 1X7Q A K127N *Neutral Neutral 0.002 1X7Q A N127K Neutral Disease 0.664 1X7Q A I142T Neutral Neutral 0.367 1X7Q A T142I *Neutral Neutral 0.001 1X7Q A E144K *Neutral Neutral 0.005 1X7Q A K144E Neutral Disease 0.655 1X7Q A H145R *Neutral Neutral 0.001 1X7Q A R145H Neutral Neutral 0.294 1X7Q A H151R Neutral Neutral 0.048 1X7Q A R151H *Neutral Neutral 0.257 1X7Q A A152E Neutral Neutral 0.271 1X7Q A E152A *Neutral Neutral 0.019 1X7Q A R163T Neutral Neutral 0.076 1X7Q A T163R *Neutral Neutral 0.173 1X7Q A H181R *Neutral Neutral 0.000 1X7Q A R181H Neutral Neutral 0.434 1X7Q A E19K Neutral Neutral 0.458 1X7Q A K19E *Neutral Neutral 0.003 1X7Q A G65R *Neutral Neutral 0.007 1X7Q A R65G Neutral Neutral 0.218 1X7Q A H70Q *Neutral Neutral 0.143 1X7Q A Q70H Neutral Neutral 0.060 1X7Q A D77N Neutral Neutral 0.005 1X7Q A N77D *Neutral Neutral 0.361 1X7Y B R133P Disease Disease 0.987 1X7Y B H156R Disease Disease 0.785 1X7Y B G228S Disease Disease 0.811 1X8Y A E317K Disease Disease 0.819 1X8Y A R349L Disease Disease 0.795 1X8Y A R377H Disease Disease 0.851 1X8Y A R377L Disease Disease 0.857 1XAR A C251Y *Neutral Neutral 0.000 1XAR A Y251C Neutral Neutral 0.094 1XGG A R150Q Disease Disease 0.555 1XGG A M225K Disease Neutral 0.337 1XGG A R233W Disease Disease 0.837 1XH3 A L103V Neutral Neutral 0.028 1XH3 A V103L *Neutral Neutral 0.112 1XH3 A F109L *Neutral Neutral 0.012 1XH3 A L109F Neutral Neutral 0.233 1XH3 A D114N Neutral Neutral 0.279 1XH3 A N114D *Neutral Neutral 0.152 1XH3 A F116S *Neutral Disease 0.551 1XH3 A S116F Neutral Neutral 0.128 1XH3 A S116Y Neutral Neutral 0.051 1XH3 A Y116S *Neutral Disease 0.642 1XH3 A L156R Neutral Neutral 0.116 1XH3 A R156L *Neutral Neutral 0.335 1XH3 A G16V Neutral Disease 0.508 1XH3 A V16G *Neutral Neutral 0.000 1XH3 A A24S Neutral Neutral 0.108 1XH3 A S24A *Neutral Neutral 0.012 1XH3 A E45T *Neutral Neutral 0.211 1XH3 A T45E Neutral Neutral 0.161 1XH3 A E63N *Neutral Neutral 0.163 1XH3 A N63E Neutral Neutral 0.019 1XH3 A F67S Neutral Neutral 0.050 1XH3 A S67F *Neutral Neutral 0.154 1XH3 A D74Y *Neutral Neutral 0.129 1XH3 A Y74D Neutral Neutral 0.258 1XH3 A D83G *Neutral Neutral 0.003 1XH3 A G83D Neutral Neutral 0.283 1XH3 A R97S Neutral Disease 0.555 1XH3 A S97R *Neutral Neutral 0.027 1XHR A I102V Neutral Neutral 0.250 1XHR A V102I *Neutral Neutral 0.001 1XHR A G160R *Neutral Neutral 0.017 1XHR A R160G Neutral Neutral 0.411 1XHR A Q192R Neutral Neutral 0.124 1XHR A R192Q *Neutral Neutral 0.392 1XHR A L55M *Neutral Neutral 0.322 1XHR A M55L Neutral Neutral 0.153 1XJ7 A I664N Disease Disease 0.815 1XJB B L172Q Neutral Neutral 0.057 1XJB B Q172L *Neutral Neutral 0.360 1XJB B F46Y Neutral Neutral 0.002 1XJB B Y46F *Neutral Disease 0.732 1XK4 D H20R Neutral Disease 0.820 1XK4 D R20H *Neutral Neutral 0.000 1XNA A M10V *Neutral Neutral 0.002 1XNA A V10M Neutral Disease 0.793 1XNA A H107R *Neutral Neutral 0.003 1XNA A R107H Neutral Disease 0.747 1XNA A L7R *Neutral Neutral 0.005 1XNA A R7L Neutral Disease 0.598 1XNA A A72V *Neutral Neutral 0.002 1XNA A V72A Neutral Disease 0.869 1XPA A C108F Disease Disease 0.901 1XPA A R130K Disease Disease 0.743 1XPA A Q185H Disease Disease 0.861 1XPD A R104Q Disease Disease 0.687 1XPD A S117Y *Neutral Neutral 0.009 1XPD A Y117S Neutral Neutral 0.369 1XPD A R135L Disease Disease 0.595 1XPD A R164Q Disease Disease 0.854 1XPD A A174F Disease Disease 0.596 1XPD A S182A Disease Neutral 0.028 1XPD A F184L Disease Disease 0.894 1XPD A G185S Disease Disease 0.893 1XPD A R188Q Disease Disease 0.834 1XPD A K198E Disease Disease 0.573 1XPD A M209T Disease Neutral 0.286 1XPD A E212K Disease Disease 0.908 1XPD A S213F Disease Disease 0.821 1XPD A S213Y Neutral Disease 0.862 1XPD A Y213S *Neutral Neutral 0.017 1XPD A T237M Disease Disease 0.712 1XPD A R263G Disease Disease 0.682 1XPD A P264L Disease Disease 0.875 1XPD A M271T Disease Disease 0.648 1XPD A C273R *Neutral Neutral 0.061 1XPD A R273C Neutral Neutral 0.393 1XPD A R40T Neutral Neutral 0.346 1XPD A T40R *Neutral Neutral 0.040 1XPD A E53Q Disease Neutral 0.176 1XPD A S56P Disease Disease 0.627 1XPD A S58R Disease Neutral 0.154 1XPD A E59D Disease Neutral 0.220 1XPD A V69I Disease Neutral 0.011 1XPD A L81F Disease Disease 0.856 1XPD A Y82F Disease Disease 0.618 1XPD A V95L Disease Disease 0.591 1XPD A V95M Disease Neutral 0.314 1XPH A D291N Neutral Neutral 0.057 1XPH A N291D *Neutral Neutral 0.002 1XQ8 A A30P Disease Disease 0.804 1XQ8 A E46K Disease Disease 0.771 1XQ8 A A53T Disease Neutral 0.007 1XR9 A H113Y Neutral Neutral 0.005 1XR9 A Y113H *Neutral Disease 0.626 1XR9 A L156W *Neutral Neutral 0.124 1XR9 A W156L Neutral Neutral 0.209 1XR9 A A24S Neutral Neutral 0.160 1XR9 A S24A *Neutral Neutral 0.018 1XR9 A L250P *Neutral Neutral 0.003 1XR9 A P250L Neutral Neutral 0.436 1XR9 A E63N Neutral Neutral 0.206 1XR9 A N63E *Neutral Neutral 0.022 1XR9 A C67S *Neutral Neutral 0.072 1XR9 A S67C Neutral Neutral 0.212 1XR9 A S67Y Neutral Neutral 0.126 1XR9 A Y67S *Neutral Neutral 0.090 1XR9 A L95W Neutral Disease 0.591 1XR9 A W95L *Neutral Neutral 0.031 1XR9 A R97T Neutral Neutral 0.489 1XR9 A T97R *Neutral Neutral 0.021 1XW5 A N172S *Neutral Neutral 0.038 1XW5 A S172N Neutral Neutral 0.139 1XW6 A K172N Neutral Neutral 0.084 1XW6 A N172K *Neutral Neutral 0.018 1XW6 A S209T Neutral Neutral 0.259 1XW6 A T209S *Neutral Neutral 0.119 1XWD B C51G Disease Disease 0.979 1XWD C S128Y Disease Disease 0.629 1XWD C I160T Disease Disease 0.896 1XWD C A189V Disease Disease 0.874 1XWD C D224V Disease Disease 0.816 1XWN A C36S Neutral Neutral 0.403 1XWN A S36C *Neutral Neutral 0.106 1XWS A E124Q Neutral Neutral 0.383 1XWS A Q124E *Neutral Neutral 0.114 1XWS A E135K Neutral Neutral 0.255 1XWS A K135E *Neutral Neutral 0.086 1XWS A D142E *Neutral Neutral 0.253 1XWS A E142D Neutral Neutral 0.073 1XX0 A K340R Neutral Neutral 0.427 1XX0 A R340K *Neutral Neutral 0.065 1XX9 A T115I Disease Neutral 0.261 1XX9 A Y133H Disease Disease 0.604 1XX9 A P161L Disease Disease 0.812 1XX9 A E186K Disease Neutral 0.207 1XX9 A W203S Disease Disease 0.811 1XX9 A S214R Disease Disease 0.868 1XX9 A I238S Disease Disease 0.726 1XX9 A R27W *Neutral Neutral 0.006 1XX9 A W27R Neutral Disease 0.718 1XX9 A T32N Disease Disease 0.569 1XX9 A G42V Disease Disease 0.938 1XX9 A A56V Disease Disease 0.901 1XX9 A F82V Disease Neutral 0.098 1XZ0 A I13T Neutral Neutral 0.383 1XZ0 A T13I *Neutral Neutral 0.006 1XZ0 A C51W *Neutral Neutral 0.049 1XZ0 A W51C Neutral Neutral 0.176 1Y1A A I106T Neutral Neutral 0.268 1Y1A A T106I *Neutral Neutral 0.060 1Y1A A S44T Neutral Neutral 0.052 1Y1A A T44S *Neutral Neutral 0.049 1Y24 A Q105R *Neutral Neutral 0.034 1Y24 A R105Q Neutral Neutral 0.024 1Y24 A G116R Neutral Neutral 0.153 1Y24 A R116G *Neutral Neutral 0.090 1Y24 A M133I Disease Disease 0.883 1Y24 A E182K Disease Disease 0.938 1Y24 A G208D Disease Disease 0.882 1Y24 A L218P Disease Disease 0.918 1Y24 A L238Q Disease Disease 0.880 1Y24 A S260F Disease Neutral 0.500 1Y24 A A279V *Neutral Neutral 0.017 1Y24 A V279A Neutral Disease 0.519 1Y24 A A327P Disease Disease 0.837 1Y24 A L346R Disease Disease 0.789 1Y24 A D349N Disease Disease 0.894 1Y24 A D349Y Disease Disease 0.875 1Y24 A N350I Disease Disease 0.522 1Y24 A A361T Neutral Neutral 0.029 1Y24 A T361A *Neutral Neutral 0.471 1Y24 A R363C Disease Disease 0.917 1Y24 A T366P Disease Disease 0.873 1Y24 A Q380R Disease Disease 0.861 1Y24 A R383H Disease Disease 0.774 1Y24 A T388R Disease Neutral 0.481 1Y24 A G409R Disease Neutral 0.374 1Y24 A S423R Disease Disease 0.759 1Y24 A I454V *Neutral Neutral 0.051 1Y24 A V454I Neutral Neutral 0.135 1Y24 A R489P Disease Disease 0.783 1Y24 A L490P Disease Disease 0.711 1Y24 A R492P Disease Disease 0.832 1Y24 A P496L Disease Disease 0.789 1Y24 A M504T Disease Disease 0.858 1Y24 A G51D Disease Disease 0.939 1Y24 A A75T Disease Disease 0.594 1Y24 A A79V Disease Neutral 0.470 1Y24 A H82P Disease Disease 0.923 1Y24 A R89Q Disease Disease 0.913 1Y24 A R89W Disease Disease 0.935 1Y4J B D51E *Neutral Neutral 0.001 1Y4J B E51D Neutral Disease 0.802 1Y9V A R100Q Disease Disease 0.593 1Y9V A R121Q Disease Disease 0.834 1Y9V A H126D Disease Neutral 0.015 1Y9V A A150E Disease Neutral 0.275 1Y9V A R50P Disease Disease 0.903 1Y9V A A54V Disease Disease 0.666 1Y9V A D57G Disease Disease 0.837 1Y9V A D57H Disease Disease 0.854 1Y9V A F83S Disease Disease 0.889 1Y9V A S96G Disease Neutral 0.303 1YB5 A I176V Neutral Neutral 0.001 1YB5 A V176I *Neutral Disease 0.674 1YB5 A E183K Neutral Neutral 0.134 1YB5 A K183E *Neutral Neutral 0.017 1YB5 A P66S Neutral Neutral 0.209 1YB5 A S66P *Neutral Neutral 0.001 1YCI A A41P *Neutral Neutral 0.033 1YCI A P41A Neutral Disease 0.505 1YCK A G13V *Neutral Neutral 0.010 1YCK A V13G Neutral Disease 0.769 1YH7 A I184M Neutral Disease 0.718 1YH7 A M184I *Neutral Neutral 0.011 1YH7 A A198V Disease Disease 0.787 1YH7 A R239Q Disease Disease 0.940 1YH7 A D274G *Neutral Neutral 0.186 1YH7 A G274D Neutral Neutral 0.477 1YH7 A P28T Disease Disease 0.645 1YH7 A T288M Disease Disease 0.798 1YH7 A V32M Disease Disease 0.532 1YH7 A A338V *Neutral Neutral 0.095 1YH7 A V338A Neutral Neutral 0.186 1YH7 A G346S Disease Disease 0.841 1YH7 A G349S Disease Disease 0.957 1YH7 A G36R Disease Disease 0.902 1YH7 A A384P Disease Disease 0.756 1YH7 A H44Y Disease Disease 0.959 1YH7 A R68C Disease Disease 0.904 1YKR A S15Y *Neutral Neutral 0.001 1YKR A Y15S Neutral Disease 0.800 1YKR A L18V *Neutral Neutral 0.000 1YKR A V18L Neutral Disease 0.879 1YKR A S290T *Neutral Neutral 0.049 1YKR A T290S Neutral Neutral 0.095 1YOV A F101S *Neutral Neutral 0.133 1YOV A S101F Neutral Neutral 0.348 1YPQ B K167N Neutral Neutral 0.043 1YPQ B N167K *Neutral Neutral 0.056 1YTQ A A64S Neutral Neutral 0.220 1YTQ A S64A *Neutral Neutral 0.238 1YXM A E149K Neutral Neutral 0.207 1YXM A K149E *Neutral Neutral 0.154 1YXM A F297L Neutral Neutral 0.194 1YXM A L297F *Neutral Neutral 0.003 1Z09 A R13S *Neutral Neutral 0.012 1Z09 A S13R Neutral Neutral 0.489 1Z09 A F71I *Neutral Neutral 0.007 1Z09 A I71F Neutral Disease 0.687 1Z0Y A Q164R *Neutral Neutral 0.000 1Z0Y A R164Q Neutral Neutral 0.009 1Z0Y A C205Y *Neutral Neutral 0.001 1Z0Y A Y205C Neutral Neutral 0.055 1Z6C A E163G Disease Disease 0.856 1Z6C A R192K Disease Disease 0.534 1Z6C A C200S Disease Disease 0.892 1Z6C A D202N Disease Disease 0.875 1Z6C A D204G Disease Disease 0.780 1Z6C A C206G Disease Disease 0.903 1Z6C A E208K Disease Disease 0.648 1Z6C A N217S Disease Disease 0.910 1Z6C A C224R Disease Disease 0.926 1Z6C A C224W Disease Disease 0.906 1Z6C A Y225C Disease Disease 0.653 1Z6C A C226S Disease Disease 0.896 1Z6X A A68V *Neutral Neutral 0.060 1Z6X A V68A Neutral Disease 0.716 1Z7X W L169P *Neutral Neutral 0.026 1Z7X W P169L Neutral Disease 0.610 1Z8E A L46P Neutral Neutral 0.387 1Z8E A P46L *Neutral Neutral 0.012 1Z8L A L627V *Neutral Neutral 0.064 1Z8L A V627L Neutral Neutral 0.114 1Z8L A H75Y *Neutral Neutral 0.056 1Z8L A Y75H Neutral Neutral 0.129 1Z9I A E41A Disease Disease 0.705 1Z9I A E41K Disease Disease 0.815 1Z9I A G51A Disease Disease 0.773 1Z9I A G51C Disease Disease 0.843 1Z9I A G51D Disease Disease 0.823 1Z9I A G51S Disease Disease 0.790 1Z9I A I6V *Neutral Neutral 0.013 1Z9I A V6I Neutral Neutral 0.174 1ZBQ A H106R *Neutral Neutral 0.109 1ZBQ A R106H Neutral Neutral 0.362 1ZBQ A K140N Neutral Neutral 0.241 1ZBQ A N140K *Neutral Neutral 0.007 1ZBQ A G16S Disease Disease 0.906 1ZBQ A S292T *Neutral Neutral 0.024 1ZBQ A T292S Neutral Neutral 0.019 1ZBQ A F90L Neutral Disease 0.593 1ZBQ A L90F *Neutral Neutral 0.012 1ZD3 A C103R *Neutral Neutral 0.008 1ZD3 A R103C Neutral Neutral 0.449 1ZD3 A C154Y Neutral Disease 0.737 1ZD3 A Y154C *Neutral Neutral 0.006 1ZD3 A A21G *Neutral Neutral 0.046 1ZD3 A G21A Neutral Neutral 0.083 1ZD3 A L223P *Neutral Neutral 0.002 1ZD3 A P223L Neutral Neutral 0.217 1ZD3 A Q285R *Neutral Neutral 0.006 1ZD3 A R285Q Neutral Disease 0.808 1ZD3 A M367V Neutral Neutral 0.039 1ZD3 A V367M *Neutral Neutral 0.039 1ZD3 A E469G Neutral Neutral 0.149 1ZD3 A G469E *Neutral Neutral 0.058 1ZD3 A Q52R *Neutral Neutral 0.005 1ZD3 A R52Q Neutral Neutral 0.349 1ZD3 A K55R Neutral Neutral 0.002 1ZD3 A R55K *Neutral Disease 0.509 1ZED A P209R *Neutral Neutral 0.176 1ZED A R209P Neutral Neutral 0.009 1ZED A H241R *Neutral Neutral 0.189 1ZED A R241H Neutral Neutral 0.252 1ZED A L3P *Neutral Neutral 0.001 1ZED A P3L Neutral Disease 0.691 1ZED A E429G Neutral Neutral 0.154 1ZED A G429E *Neutral Neutral 0.122 1ZED A I67L Neutral Neutral 0.148 1ZED A L67I *Neutral Neutral 0.118 1ZGY A Q286P Disease Disease 0.968 1ZGY A R288H Disease Disease 0.861 1ZGY A F360L Disease Disease 0.820 1ZGY A R397C Disease Disease 0.987 1ZLL A R9C Disease Disease 0.915 1ZLM A N48S Neutral Disease 0.840 1ZLM A S48N *Neutral Neutral 0.000 1ZMD E L296V Neutral Neutral 0.163 1ZMD E V296L *Neutral Neutral 0.145 1ZMD E K69T *Neutral Neutral 0.098 1ZMD E T69K Neutral Neutral 0.053 1ZN8 B L110P Disease Disease 0.987 1ZN8 B Q121R Neutral Disease 0.869 1ZN8 B R121Q *Neutral Neutral 0.391 1ZN8 B M136T Disease Disease 0.939 1ZN8 B V150F Disease Disease 0.953 1ZN8 B C153R Disease Disease 0.899 1ZN8 B D65V Disease Disease 0.933 1ZNC A R193S Disease Disease 0.772 1ZNC A L211V *Neutral Neutral 0.004 1ZNC A V211L Neutral Disease 0.619 1ZRH A K262R Neutral Neutral 0.077 1ZRH A R262K *Neutral Neutral 0.006 1ZSX A E74K Neutral Disease 0.973 1ZSX A K74E *Neutral Neutral 0.465 1ZT3 A I183V *Neutral Neutral 0.004 1ZT3 A V183I Neutral Disease 0.532 1ZT4 C S46T *Neutral Neutral 0.001 1ZT4 C T46S Neutral Neutral 0.226 1ZV0 B A163T Neutral Neutral 0.070 1ZV0 B T163A *Neutral Neutral 0.034 1ZV0 B A244S Neutral Neutral 0.071 1ZV0 B S244A *Neutral Neutral 0.006 1ZV0 B T282M Disease Neutral 0.015 1ZV0 B C289W Neutral Neutral 0.098 1ZV0 B W289C *Neutral Neutral 0.011 1ZV0 B P336T *Neutral Neutral 0.001 1ZV0 B T336P Neutral Neutral 0.019 1ZV0 B L48V Neutral Neutral 0.135 1ZV0 B V48L *Neutral Neutral 0.001 1ZX0 C C169Y Disease Disease 0.913 1ZX0 C L197P Disease Disease 0.974 1ZX0 C W20S Disease Disease 0.915 1ZX0 C M209T *Neutral Neutral 0.001 1ZX0 C T209M Neutral Disease 0.664 1ZX0 C M50L Disease Disease 0.903 1ZX0 C H51P Disease Disease 0.882 1ZX0 C A54P Disease Disease 0.919 2A01 A D102H Neutral Neutral 0.389 2A01 A H102D *Neutral Neutral 0.001 2A01 A K107M Neutral Neutral 0.236 2A01 A M107K *Neutral Neutral 0.004 2A01 A E139G Neutral Neutral 0.061 2A01 A G139E *Neutral Neutral 0.009 2A01 A E147V Neutral Disease 0.596 2A01 A V147E *Neutral Neutral 0.002 2A01 A P160R *Neutral Neutral 0.002 2A01 A R160P Neutral Disease 0.704 2A01 A P165R Neutral Disease 0.626 2A01 A R165P *Neutral Neutral 0.001 2A01 A G26R Disease Disease 0.609 2A01 A P3R Neutral Neutral 0.457 2A01 A R3P *Neutral Neutral 0.001 2A01 A A37T Neutral Neutral 0.269 2A01 A T37A *Neutral Neutral 0.018 2A01 A L60R Disease Disease 0.627 2A01 A I68T *Neutral Neutral 0.016 2A01 A T68I Neutral Neutral 0.448 2A01 A D89E Neutral Neutral 0.022 2A01 A E89D *Neutral Neutral 0.004 2A0Z A I284N *Neutral Neutral 0.000 2A0Z A N284I Neutral Neutral 0.391 2A0Z A D307Y *Neutral Neutral 0.032 2A0Z A Y307D Neutral Neutral 0.070 2A0Z A F412L *Neutral Neutral 0.001 2A0Z A L412F Neutral Neutral 0.500 2A0Z A P554S Disease Neutral 0.329 2A1J A A849D Neutral Disease 0.823 2A1J A D849A *Neutral Neutral 0.001 2A1J A I862V Neutral Disease 0.777 2A1J A V862I *Neutral Neutral 0.000 2A1J A E864G Neutral Disease 0.855 2A1J A G864E *Neutral Neutral 0.001 2A24 B Q79R *Neutral Neutral 0.108 2A24 B R79Q Neutral Disease 0.803 2A24 B E84K Neutral Disease 0.743 2A24 B K84E *Neutral Neutral 0.172 2A27 B R261W Neutral Neutral 0.329 2A27 B W261R *Neutral Neutral 0.031 2A27 B R50W Neutral Neutral 0.391 2A27 B W50R *Neutral Neutral 0.021 2A2R A I104V Neutral Neutral 0.119 2A2R A V104I *Neutral Neutral 0.098 2A2R A A113V Neutral Neutral 0.144 2A2R A V113A *Neutral Neutral 0.027 2A2R A D168G *Neutral Neutral 0.104 2A2R A G168D Neutral Neutral 0.246 2A38 A V54M Disease Neutral 0.368 2A38 A D60Y Neutral Neutral 0.381 2A38 A Y60D *Neutral Neutral 0.017 2A7R A D242G *Neutral Neutral 0.000 2A7R A G242D Neutral Disease 0.948 2A83 A D114H *Neutral Neutral 0.176 2A83 A H114D Neutral Neutral 0.126 2A83 A D116H Neutral Neutral 0.158 2A83 A D116Y Neutral Neutral 0.028 2A83 A H116D *Neutral Neutral 0.216 2A83 A Y116D *Neutral Neutral 0.366 2A83 A R131S *Neutral Neutral 0.282 2A83 A S131R Neutral Neutral 0.003 2A83 A E152V *Neutral Neutral 0.054 2A83 A V152E Neutral Neutral 0.161 2A83 A A211G Neutral Disease 0.531 2A83 A G211A *Neutral Neutral 0.004 2A83 A A41T Neutral Neutral 0.131 2A83 A T41A *Neutral Neutral 0.002 2A83 A H59Y *Neutral Neutral 0.001 2A83 A Y59H Neutral Disease 0.628 2A83 A D77N Neutral Neutral 0.003 2A83 A D77S Neutral Neutral 0.069 2A83 A N77D *Neutral Neutral 0.247 2A83 A S77D *Neutral Neutral 0.141 2A83 A N80T *Neutral Neutral 0.010 2A83 A T80N Neutral Neutral 0.208 2A83 A N97S Neutral Neutral 0.175 2A83 A S97N *Neutral Neutral 0.214 2ABT A G101V Neutral Disease 0.679 2ABT A V101G *Neutral Neutral 0.001 2ABT A K102N *Neutral Neutral 0.126 2ABT A N102K Neutral Neutral 0.216 2ABT A Q204R *Neutral Neutral 0.007 2ABT A R204Q Neutral Neutral 0.304 2ABT A M238V *Neutral Neutral 0.012 2ABT A V238M Neutral Neutral 0.123 2ABT A A460P Neutral Disease 0.811 2ABT A P460A *Neutral Neutral 0.002 2ABT A M559T *Neutral Neutral 0.060 2ABT A T559M Neutral Neutral 0.291 2ABT A D89H Neutral Neutral 0.115 2ABT A H89D *Neutral Neutral 0.006 2ABV A E253K Neutral Neutral 0.065 2ABV A K253E *Neutral Neutral 0.013 2AC0 A G105C Disease Disease 0.978 2AC0 A S106R Disease Neutral 0.371 2AC0 A R110L Disease Disease 0.838 2AC0 A Y126C Disease Disease 0.971 2AC0 A K132E Disease Disease 0.930 2AC0 A M133R Disease Disease 0.932 2AC0 A M133T Disease Disease 0.923 2AC0 A A138P Disease Disease 0.953 2AC0 A A138S Disease Disease 0.910 2AC0 A C141Y Disease Disease 0.978 2AC0 A Q144L Disease Disease 0.941 2AC0 A P151S Disease Disease 0.942 2AC0 A P151T Disease Disease 0.917 2AC0 A P152L Disease Disease 0.893 2AC0 A G154V Disease Disease 0.905 2AC0 A T155N Disease Disease 0.919 2AC0 A R156H Disease Disease 0.896 2AC0 A R158G Disease Disease 0.972 2AC0 A R158H Disease Disease 0.970 2AC0 A I162N Disease Disease 0.954 2AC0 A Y163C Disease Disease 0.958 2AC0 A Q167K Disease Disease 0.833 2AC0 A V172F Disease Disease 0.949 2AC0 A V173M Disease Disease 0.947 2AC0 A R174G Disease Disease 0.935 2AC0 A R175G Disease Disease 0.979 2AC0 A R175H Disease Disease 0.971 2AC0 A R175L Disease Disease 0.980 2AC0 A H179Y Disease Disease 0.973 2AC0 A E180K Disease Disease 0.953 2AC0 A R181C Disease Disease 0.931 2AC0 A R181H Disease Disease 0.863 2AC0 A R181L Disease Disease 0.557 2AC0 A R181P Disease Disease 0.941 2AC0 A A189V Disease Disease 0.927 2AC0 A H193R Disease Disease 0.949 2AC0 A R196P Disease Disease 0.987 2AC0 A V197E Disease Disease 0.971 2AC0 A V197M Disease Disease 0.934 2AC0 A N210Y Disease Neutral 0.234 2AC0 A R213P Disease Disease 0.983 2AC0 A R213Q Disease Disease 0.945 2AC0 A M217V *Neutral Neutral 0.132 2AC0 A V217M Neutral Disease 0.826 2AC0 A P219S Disease Disease 0.942 2AC0 A Y220C Disease Disease 0.950 2AC0 A Y220S Disease Disease 0.942 2AC0 A S227T Disease Neutral 0.239 2AC0 A H233D Disease Disease 0.872 2AC0 A Y234C Disease Disease 0.967 2AC0 A N235D Disease Disease 0.950 2AC0 A N235S Disease Disease 0.871 2AC0 A Y236C Disease Disease 0.965 2AC0 A M237I Disease Disease 0.958 2AC0 A C238G Disease Disease 0.972 2AC0 A C238S Disease Disease 0.978 2AC0 A C238Y Disease Disease 0.978 2AC0 A S241F Disease Disease 0.898 2AC0 A S241T Disease Disease 0.874 2AC0 A C242Y Disease Disease 0.974 2AC0 A G244D Disease Disease 0.930 2AC0 A G244V Disease Disease 0.919 2AC0 A G245C Disease Disease 0.969 2AC0 A G245D Disease Disease 0.963 2AC0 A G245S Disease Disease 0.965 2AC0 A G245V Disease Disease 0.953 2AC0 A M246V Disease Disease 0.963 2AC0 A R248Q Disease Disease 0.911 2AC0 A R248W Disease Disease 0.908 2AC0 A I251M Disease Disease 0.933 2AC0 A L252P Disease Disease 0.981 2AC0 A T256I Disease Disease 0.944 2AC0 A L257Q Disease Disease 0.960 2AC0 A E258K Disease Disease 0.975 2AC0 A L265P Disease Disease 0.981 2AC0 A R267Q Disease Disease 0.952 2AC0 A E271V Disease Disease 0.934 2AC0 A V272A Disease Disease 0.837 2AC0 A V272L Disease Disease 0.937 2AC0 A R273C Disease Disease 0.979 2AC0 A R273G Disease Disease 0.963 2AC0 A R273H Disease Disease 0.958 2AC0 A R273L Disease Disease 0.965 2AC0 A R273S Disease Disease 0.974 2AC0 A C275Y Disease Disease 0.966 2AC0 A C277Y Disease Disease 0.963 2AC0 A P278L Disease Disease 0.952 2AC0 A P278S Disease Disease 0.963 2AC0 A P278T Disease Disease 0.951 2AC0 A R280K Disease Disease 0.974 2AC0 A D281G Disease Disease 0.957 2AC0 A D281N Disease Disease 0.969 2AC0 A D281V Disease Disease 0.958 2AC0 A R282G Disease Disease 0.969 2AC0 A R282Q Disease Disease 0.951 2AC0 A R282W Disease Disease 0.954 2AC0 A R283C Disease Disease 0.911 2AC0 A R283H Disease Disease 0.842 2AC0 A E285Q Disease Disease 0.835 2AC0 A E286A Disease Disease 0.948 2AC0 A R290H Disease Disease 0.744 2AC0 A R290L Disease Disease 0.851 2AC0 A V97I Disease Neutral 0.150 2ACH A A144G Neutral Neutral 0.121 2ACH A G144A *Neutral Neutral 0.073 2ACH A P228A Disease Neutral 0.165 2ACH A K243R Neutral Neutral 0.380 2ACH A R243K *Neutral Disease 0.601 2ACH A L55P Disease Disease 0.647 2AEB A I11T Disease Disease 0.772 2AEB A G138V Disease Disease 0.882 2AEB A G235R Disease Disease 0.875 2AEB A S290T *Neutral Neutral 0.022 2AEB A T290S Neutral Neutral 0.410 2AEX A V135A Disease Disease 0.850 2AEX A G189S Disease Disease 0.974 2AEX A G197W Disease Disease 0.954 2AEX A E201K Disease Disease 0.969 2AEX A S208F Disease Disease 0.956 2AEX A L214R Disease Disease 0.772 2AEX A P249R Disease Disease 0.929 2AEX A P249S Disease Disease 0.937 2AEX A H272N *Neutral Neutral 0.174 2AEX A N272H Neutral Neutral 0.426 2AEX A G279R Disease Disease 0.972 2AEX A G280R Disease Disease 0.972 2AEX A I294V *Neutral Neutral 0.156 2AEX A V294I Neutral Neutral 0.306 2AEX A H295D Disease Disease 0.912 2AEX A R328C Disease Disease 0.976 2AEX A R331W Disease Disease 0.778 2AEX A C352R *Neutral Neutral 0.320 2AEX A R352C Neutral Disease 0.715 2AEX A K404E Disease Disease 0.590 2AEX A W427R Disease Disease 0.934 2AEX A R447C Disease Disease 0.860 2AFL A S17I Disease Disease 0.809 2AFL A L4I Disease Disease 0.879 2AFL A V79I Disease Neutral 0.241 2AHS A A1934G *Neutral Neutral 0.044 2AHS A G1934A Neutral Neutral 0.380 2AM9 A Q670R Disease Disease 0.849 2AM9 A P671H Disease Disease 0.764 2AM9 A I672T Disease Neutral 0.034 2AM9 A L677P Disease Disease 0.963 2AM9 A E681K Disease Disease 0.959 2AM9 A P682T Disease Disease 0.927 2AM9 A G683A Disease Neutral 0.314 2AM9 A V684I Disease Neutral 0.223 2AM9 A C686R Disease Disease 0.716 2AM9 A A687V Disease Disease 0.909 2AM9 A G688E Disease Disease 0.806 2AM9 A D695H Disease Disease 0.813 2AM9 A D695N Disease Disease 0.851 2AM9 A D695V Disease Disease 0.814 2AM9 A L700M Disease Neutral 0.125 2AM9 A L701F Disease Disease 0.829 2AM9 A L701H Disease Disease 0.836 2AM9 A S702A Disease Disease 0.599 2AM9 A S703C Disease Disease 0.783 2AM9 A S703G Disease Disease 0.677 2AM9 A N705S Disease Disease 0.818 2AM9 A N705Y Disease Disease 0.816 2AM9 A L707R Disease Disease 0.944 2AM9 A G708A Disease Neutral 0.034 2AM9 A G708V Disease Disease 0.837 2AM9 A R710T Disease Disease 0.915 2AM9 A Q711E Disease Neutral 0.116 2AM9 A L712F Disease Disease 0.931 2AM9 A V715M Disease Neutral 0.074 2AM9 A K717E Disease Disease 0.725 2AM9 A K720E Disease Disease 0.914 2AM9 A A721T Disease Disease 0.566 2AM9 A L722F Disease Disease 0.913 2AM9 A P723S Disease Disease 0.933 2AM9 A G724D Disease Disease 0.942 2AM9 A R726L Disease Disease 0.519 2AM9 A N727K Disease Disease 0.647 2AM9 A L728S Disease Disease 0.939 2AM9 A V730M Disease Neutral 0.353 2AM9 A D732N Disease Disease 0.928 2AM9 A D732Y Disease Disease 0.932 2AM9 A Q733H Disease Disease 0.940 2AM9 A I737T Disease Disease 0.855 2AM9 A W741R Disease Disease 0.955 2AM9 A M742I Disease Disease 0.931 2AM9 A M742V Disease Disease 0.937 2AM9 A G743E Disease Neutral 0.047 2AM9 A G743V Disease Disease 0.828 2AM9 A L744F Disease Disease 0.860 2AM9 A M745T Disease Disease 0.905 2AM9 A V746M Disease Neutral 0.058 2AM9 A A748D Disease Disease 0.890 2AM9 A A748T Disease Disease 0.832 2AM9 A A748V Disease Disease 0.864 2AM9 A M749I Disease Disease 0.765 2AM9 A M749V Disease Disease 0.788 2AM9 A G750D Disease Disease 0.896 2AM9 A G750S Disease Disease 0.759 2AM9 A W751R Disease Disease 0.923 2AM9 A R752Q Disease Disease 0.944 2AM9 A F754L Disease Neutral 0.380 2AM9 A F754V Disease Neutral 0.389 2AM9 A T755A Disease Neutral 0.342 2AM9 A N756S Disease Neutral 0.405 2AM9 A V757A Disease Neutral 0.443 2AM9 A N758T Disease Neutral 0.476 2AM9 A S759F Disease Disease 0.690 2AM9 A S759P Disease Disease 0.855 2AM9 A L762F Disease Disease 0.934 2AM9 A Y763C Disease Disease 0.630 2AM9 A Y763H Disease Disease 0.807 2AM9 A F764L Disease Disease 0.919 2AM9 A A765T Disease Disease 0.947 2AM9 A A765V Disease Disease 0.954 2AM9 A P766S Disease Disease 0.879 2AM9 A D767E Disease Disease 0.900 2AM9 A L768P Disease Disease 0.971 2AM9 A N771H Disease Disease 0.741 2AM9 A E772A Disease Disease 0.892 2AM9 A E772G Disease Disease 0.894 2AM9 A R774C Disease Disease 0.945 2AM9 A R774H Disease Disease 0.833 2AM9 A R779W Disease Disease 0.719 2AM9 A M780I Disease Disease 0.842 2AM9 A S782N Disease Disease 0.569 2AM9 A C784Y Disease Disease 0.917 2AM9 A M787V Disease Disease 0.909 2AM9 A R788S Disease Disease 0.788 2AM9 A L790F Disease Disease 0.776 2AM9 A S791P Disease Disease 0.860 2AM9 A D793E *Neutral Neutral 0.027 2AM9 A E793D Neutral Disease 0.799 2AM9 A F794S Disease Disease 0.939 2AM9 A Q798E Disease Disease 0.724 2AM9 A C806Y Disease Disease 0.919 2AM9 A M807R Disease Disease 0.819 2AM9 A M807T Disease Disease 0.853 2AM9 A M807V Disease Disease 0.750 2AM9 A L812F Disease Disease 0.933 2AM9 A S814N Disease Neutral 0.052 2AM9 A G820A Disease Disease 0.917 2AM9 A L821V Disease Disease 0.873 2AM9 A F827V Disease Disease 0.834 2AM9 A L830P Disease Disease 0.897 2AM9 A R831L Disease Disease 0.935 2AM9 A R831Q Disease Disease 0.912 2AM9 A Y834C Disease Disease 0.933 2AM9 A R840C Disease Disease 0.872 2AM9 A R840G Disease Disease 0.770 2AM9 A R840H Disease Disease 0.771 2AM9 A R840S Disease Disease 0.638 2AM9 A I841S Disease Disease 0.538 2AM9 A I842T Disease Disease 0.894 2AM9 A R846G Disease Disease 0.728 2AM9 A R854K Disease Disease 0.689 2AM9 A R855C Disease Disease 0.973 2AM9 A R855H Disease Disease 0.948 2AM9 A F856L Disease Disease 0.843 2AM9 A L863R Disease Disease 0.891 2AM9 A D864G Disease Disease 0.878 2AM9 A D864N Disease Disease 0.928 2AM9 A S865P Disease Disease 0.917 2AM9 A V866E Disease Disease 0.632 2AM9 A V866L Disease Neutral 0.113 2AM9 A V866M Disease Neutral 0.007 2AM9 A I869M Disease Neutral 0.299 2AM9 A A870G Disease Disease 0.791 2AM9 A A870V Disease Neutral 0.004 2AM9 A R871G Disease Neutral 0.335 2AM9 A H874R Disease Disease 0.798 2AM9 A H874Y Disease Disease 0.850 2AM9 A T877A Disease Disease 0.534 2AM9 A T877S Disease Disease 0.521 2AM9 A D879Y Disease Neutral 0.056 2AM9 A L880Q Disease Disease 0.690 2AM9 A L881V Disease Disease 0.547 2AM9 A M886V Disease Neutral 0.308 2AM9 A V889M Disease Disease 0.799 2AM9 A D890N Disease Neutral 0.258 2AM9 A F891L Disease Disease 0.896 2AM9 A P892L Disease Disease 0.866 2AM9 A M895T Disease Disease 0.807 2AM9 A A896T Disease Disease 0.602 2AM9 A I898T Disease Disease 0.905 2AM9 A Q902R Disease Disease 0.917 2AM9 A V903M Disease Disease 0.701 2AM9 A P904H Disease Disease 0.857 2AM9 A P904S Disease Disease 0.900 2AM9 A L907F Disease Disease 0.860 2AM9 A G909E Disease Disease 0.931 2AM9 A G909R Disease Disease 0.908 2AM9 A K910R Disease Neutral 0.214 2AM9 A V911L Disease Disease 0.845 2AM9 A P913S Disease Disease 0.847 2AM9 A F916L Disease Disease 0.906 2AM9 A H917R Disease Disease 0.915 2AM9 A Q919R Disease Disease 0.541 2APD A K158T *Neutral Neutral 0.035 2APD A T158K Neutral Neutral 0.118 2APD A L95S *Neutral Neutral 0.040 2APD A S95L Neutral Neutral 0.197 2ARY A A103T *Neutral Neutral 0.076 2ARY A T103A Neutral Neutral 0.430 2AZE B H252R *Neutral Neutral 0.009 2AZE B R252H Neutral Disease 0.832 2AZE B M276V *Neutral Neutral 0.447 2AZE B V276M Neutral Disease 0.620 2B0X A A224D Neutral Neutral 0.135 2B0X A D224A *Neutral Neutral 0.021 2B0X A N338S Neutral Neutral 0.071 2B0X A S338N *Neutral Neutral 0.012 2B3Y A A395D Neutral Neutral 0.447 2B3Y A D395A *Neutral Neutral 0.007 2B3Y A G486R Neutral Disease 0.818 2B3Y A R486G *Neutral Neutral 0.000 2B49 A D763N Neutral Neutral 0.126 2B49 A N763D *Neutral Neutral 0.062 2B6Q A M168V *Neutral Neutral 0.018 2B6Q A V168M Neutral Neutral 0.034 2B6Q A N178T Neutral Neutral 0.125 2B6Q A T178N *Neutral Neutral 0.055 2B6Q A L191P *Neutral Neutral 0.008 2B6Q A P191L Neutral Neutral 0.089 2B6Q A A234S *Neutral Neutral 0.002 2B6Q A S234A Neutral Neutral 0.013 2B6S A A95T Neutral Neutral 0.090 2B6S A T95A *Neutral Neutral 0.024 2B6U A M158T Neutral Neutral 0.094 2B6U A T158M *Neutral Neutral 0.010 2B8U A C3R Neutral Neutral 0.473 2B8U A R3C *Neutral Neutral 0.001 2BC4 D A10T *Neutral Neutral 0.011 2BC4 D T10A Neutral Neutral 0.095 2BC4 D A144E Neutral Neutral 0.187 2BC4 D A144V Neutral Neutral 0.114 2BC4 D E144A *Neutral Neutral 0.030 2BC4 D V144A *Neutral Neutral 0.029 2BC4 D I179T Neutral Neutral 0.074 2BC4 D T179I *Neutral Neutral 0.034 2BC4 D F27S *Neutral Neutral 0.016 2BC4 D S27F Neutral Neutral 0.165 2BC4 D D31V Neutral Neutral 0.089 2BC4 D V31D *Neutral Neutral 0.018 2BC4 D N53S *Neutral Neutral 0.025 2BC4 D S53N Neutral Neutral 0.080 2BCQ A R438W Neutral Disease 0.641 2BCQ A W438R *Neutral Neutral 0.255 2BDG A D147G *Neutral Neutral 0.004 2BDG A G147D Neutral Neutral 0.500 2BDG A H186AQ *Neutral Neutral 0.071 2BDG A Q186AH Neutral Neutral 0.239 2BO9 A C191G *Neutral Neutral 0.111 2BO9 A G191C Neutral Disease 0.614 2BO9 A P46T Neutral Neutral 0.353 2BO9 A T46P *Neutral Neutral 0.031 2BO9 A L71R *Neutral Neutral 0.000 2BO9 A R71L Neutral Disease 0.891 2BP1 A M136V *Neutral Neutral 0.082 2BP1 A V136M Neutral Disease 0.507 2BP1 A A143T Neutral Disease 0.644 2BP1 A T143A *Neutral Neutral 0.180 2BP1 A H158Q *Neutral Neutral 0.399 2BP1 A Q158H Neutral Neutral 0.198 2BP1 A E181K Neutral Neutral 0.139 2BP1 A K181E *Neutral Neutral 0.039 2BP1 A G199S Neutral Neutral 0.096 2BP1 A S199G *Neutral Neutral 0.115 2BP1 A C215Y Neutral Neutral 0.195 2BP1 A Y215C *Neutral Neutral 0.262 2BP1 A N256S *Neutral Neutral 0.013 2BP1 A S256N Neutral Neutral 0.060 2BQ8 X M127V *Neutral Neutral 0.039 2BQ8 X V127M Neutral Neutral 0.215 2BQ8 X M179V *Neutral Neutral 0.177 2BQ8 X V179M Neutral Disease 0.549 2BQ8 X I200V *Neutral Neutral 0.038 2BQ8 X V200I Neutral Neutral 0.162 2BZ6 H A150T Neutral Neutral 0.056 2BZ6 H T150A *Neutral Neutral 0.016 2BZ6 H S165T *Neutral Neutral 0.161 2BZ6 H T165S Neutral Neutral 0.105 2BZ6 H Q204R *Neutral Neutral 0.014 2BZ6 H R204Q Neutral Neutral 0.088 2BZ6 H E236K Neutral Neutral 0.120 2BZ6 H K236E *Neutral Neutral 0.118 2BZ6 H D95V *Neutral Neutral 0.078 2BZ6 H V95D Neutral Neutral 0.023 2C17 A N130D Disease Disease 0.695 2C17 A Y17S Disease Neutral 0.267 2C17 A Y282D Disease Neutral 0.344 2C17 A P295T Disease Neutral 0.302 2C17 A R300C Disease Disease 0.648 2C17 A R300H Disease Neutral 0.460 2C17 A R311Q Disease Neutral 0.464 2C17 A R315C Disease Disease 0.806 2C17 A H326L Disease Disease 0.727 2C17 A W359R Disease Disease 0.603 2C17 A F370C Disease Disease 0.613 2C17 A P381L Disease Neutral 0.152 2C17 A R393H Disease Disease 0.713 2C17 A R449C Disease Disease 0.558 2C17 A R449H Disease Neutral 0.360 2C17 A F46C Disease Disease 0.542 2C17 A R49W Disease Disease 0.753 2C17 A S59P Disease Disease 0.643 2C17 A F67V Disease Disease 0.674 2C17 A D69V Disease Neutral 0.256 2C3N A D141N Neutral Neutral 0.099 2C3N A N141D *Neutral Neutral 0.015 2C3N A I169V *Neutral Neutral 0.040 2C3N A V169I Neutral Neutral 0.237 2C3N A E173K Neutral Disease 0.785 2C3N A K173E *Neutral Neutral 0.026 2C3N A A21T Neutral Neutral 0.500 2C3N A T21A *Neutral Neutral 0.002 2C5D C M105T *Neutral Neutral 0.211 2C5D C T105M Neutral Neutral 0.266 2C6N A A125T Neutral Neutral 0.447 2C6N A T125A *Neutral Neutral 0.012 2C6N A A154T Neutral Neutral 0.249 2C6N A T154A *Neutral Neutral 0.059 2C6N A C215Y *Neutral Neutral 0.031 2C6N A Y215C Neutral Disease 0.510 2C6N A C231R *Neutral Neutral 0.006 2C6N A L231R *Neutral Neutral 0.005 2C6N A R231C Neutral Disease 0.731 2C6N A R231L Neutral Disease 0.660 2C6N A A232S Neutral Neutral 0.423 2C6N A S232A *Neutral Neutral 0.120 2C6N A L322P *Neutral Neutral 0.001 2C6N A P322L Neutral Disease 0.615 2C6N A G325R Neutral Disease 0.532 2C6N A R325G *Neutral Neutral 0.000 2C6N A Q350R *Neutral Neutral 0.031 2C6N A R350Q Neutral Neutral 0.049 2C6N A A495V *Neutral Neutral 0.278 2C6N A V495A Neutral Neutral 0.258 2C6N A R532W Neutral Neutral 0.225 2C6N A W532R *Neutral Neutral 0.020 2C6N A D563G Neutral Neutral 0.062 2C6N A G563D *Neutral Neutral 0.042 2C7A A I625R *Neutral Neutral 0.070 2C7A A R625I Neutral Disease 0.849 2C9V A E100G Disease Neutral 0.160 2C9V A E100K Disease Neutral 0.123 2C9V A D101G Disease Disease 0.699 2C9V A D101N Disease Disease 0.739 2C9V A I104F Disease Disease 0.767 2C9V A S105L Disease Disease 0.734 2C9V A L106V Disease Disease 0.784 2C9V A G108V Disease Disease 0.725 2C9V A I112M Disease Disease 0.746 2C9V A I112T Disease Disease 0.801 2C9V A I113T Disease Disease 0.764 2C9V A G114A Disease Disease 0.897 2C9V A R115G Disease Disease 0.915 2C9V A V118L Disease Disease 0.877 2C9V A G12R Disease Neutral 0.360 2C9V A D124G Disease Disease 0.769 2C9V A D124V Disease Disease 0.825 2C9V A D125H Disease Disease 0.748 2C9V A L126S Disease Disease 0.822 2C9V A S134N Disease Disease 0.848 2C9V A N139K Disease Disease 0.853 2C9V A V14G Disease Disease 0.810 2C9V A V14M Disease Disease 0.788 2C9V A L144F Disease Disease 0.713 2C9V A L144S Disease Disease 0.731 2C9V A A145T Disease Disease 0.838 2C9V A C146R Disease Disease 0.844 2C9V A G147R Disease Disease 0.859 2C9V A V148G Disease Disease 0.752 2C9V A V148I Disease Neutral 0.255 2C9V A I149T Disease Disease 0.881 2C9V A I151T Disease Neutral 0.409 2C9V A G16S Disease Disease 0.901 2C9V A F20C Disease Disease 0.878 2C9V A E21G Disease Neutral 0.297 2C9V A E21K Disease Neutral 0.345 2C9V A Q22L Disease Disease 0.795 2C9V A G37R Disease Disease 0.778 2C9V A L38R Disease Disease 0.812 2C9V A L38V Disease Disease 0.821 2C9V A A4S Disease Disease 0.848 2C9V A A4T Disease Disease 0.806 2C9V A A4V Disease Disease 0.819 2C9V A G41D Disease Disease 0.819 2C9V A G41S Disease Disease 0.715 2C9V A H43R Disease Disease 0.665 2C9V A F45C Disease Disease 0.893 2C9V A H46R Disease Disease 0.895 2C9V A H48Q Disease Disease 0.852 2C9V A H48R Disease Disease 0.859 2C9V A E49K Disease Disease 0.741 2C9V A T54R Disease Neutral 0.372 2C9V A C6F Disease Disease 0.820 2C9V A N65S Disease Disease 0.868 2C9V A L67R Disease Neutral 0.148 2C9V A V7E Disease Disease 0.848 2C9V A G72S Disease Disease 0.872 2C9V A D76Y Disease Disease 0.618 2C9V A L8Q Disease Disease 0.860 2C9V A L8V Disease Disease 0.776 2C9V A H80A Disease Disease 0.899 2C9V A L84F Disease Disease 0.810 2C9V A L84V Disease Disease 0.849 2C9V A G85R Disease Disease 0.876 2C9V A N86S Disease Disease 0.821 2C9V A V87A Disease Disease 0.647 2C9V A A89T Disease Disease 0.542 2C9V A A89V Disease Neutral 0.412 2C9V A D90A Disease Neutral 0.419 2C9V A D90V Disease Neutral 0.468 2C9V A G93A Disease Disease 0.874 2C9V A G93C Disease Disease 0.923 2C9V A G93D Disease Disease 0.911 2C9V A G93R Disease Disease 0.876 2C9V A G93V Disease Disease 0.883 2C9V A V97M Disease Disease 0.553 2C9Y A R103W Disease Disease 0.860 2C9Y A D165G Disease Disease 0.650 2C9Y A A209T Neutral Neutral 0.076 2C9Y A T209A *Neutral Neutral 0.150 2CAR B P32T Disease Neutral 0.326 2CB8 A D39N Neutral Disease 0.709 2CB8 A N39D *Neutral Neutral 0.001 2CB8 A M71V Neutral Disease 0.748 2CB8 A V71M *Neutral Neutral 0.003 2CB8 A G86R Neutral Disease 0.726 2CB8 A R86G *Neutral Neutral 0.000 2CDW A E249K Neutral Neutral 0.070 2CDW A K249E *Neutral Neutral 0.016 2CDW A M265T *Neutral Neutral 0.044 2CDW A T265M Neutral Neutral 0.134 2CDW A C353R *Neutral Neutral 0.000 2CDW A R353C Neutral Disease 0.645 2CDW A R64W *Neutral Neutral 0.435 2CDW A W64R Neutral Neutral 0.025 2CFY A D215G Neutral Neutral 0.222 2CFY A G215D *Neutral Neutral 0.060 2CH6 A R38W *Neutral Neutral 0.014 2CH6 A W38R Neutral Neutral 0.392 2CH6 A A60V Neutral Disease 0.596 2CH6 A V60A *Neutral Neutral 0.007 2CLS A P44R Neutral Disease 0.843 2CLS A R44P *Neutral Neutral 0.005 2CW6 A S142F Disease Disease 0.769 2CW6 A C174Y Disease Disease 0.946 2CW6 A F192S Disease Disease 0.744 2CW6 A I200F Disease Disease 0.876 2CW6 A S201Y Disease Disease 0.914 2CW6 A G203E Disease Disease 0.917 2CW6 A D204N Disease Disease 0.934 2CW6 A H233R Disease Disease 0.936 2CW6 A L263P Disease Disease 0.974 2CW6 A E279K Disease Disease 0.925 2CW6 A E37K Disease Disease 0.947 2CW6 A R41Q Disease Disease 0.906 2CW6 A D42E Disease Disease 0.859 2CW6 A D42G Disease Disease 0.859 2CW6 A D42H Disease Disease 0.848 2CW6 A K48N Disease Neutral 0.356 2CW6 A V70L Disease Disease 0.651 2CW6 A S75R Disease Disease 0.857 2D39 C H126Y *Neutral Neutral 0.087 2D39 C Y126H Neutral Neutral 0.076 2D4Q A I1584V Disease Neutral 0.025 2D4Q A R1590W Disease Disease 0.970 2D4Q A A1764S Disease Disease 0.968 2DF9 A L2F Disease Disease 0.861 2DF9 A P26L Disease Disease 0.801 2DF9 A T45P Disease Disease 0.898 2DF9 A L50F Disease Disease 0.672 2DF9 A R92W Disease Disease 0.787 2DFM A E12Q *Neutral Neutral 0.097 2DFM A Q12E Neutral Neutral 0.248 2DJF B D212Y Disease Disease 0.784 2DJF B V225F Disease Neutral 0.399 2DJF B Q228L Disease Disease 0.765 2DJF B R248H Disease Neutral 0.339 2DJF B R248P Disease Disease 0.648 2DJF B Q262R Disease Disease 0.771 2DJF B C267Y Disease Disease 0.797 2DJF B Y270H Disease Neutral 0.204 2DJF B G276D Disease Disease 0.904 2DJF B G276S Disease Disease 0.893 2DJF B G277S Disease Disease 0.889 2DJF B G277V Disease Disease 0.880 2DJF B Y280N Disease Neutral 0.332 2DJF B Q288R Disease Neutral 0.174 2DJF B E295G Disease Disease 0.670 2DJF B R315C Disease Disease 0.669 2DJF B Y316C Disease Neutral 0.494 2DJF B Y323C Disease Disease 0.536 2DLI A P16R *Neutral Disease 0.688 2DLI A R16P Neutral Neutral 0.033 2DLI A F45Y Neutral Neutral 0.130 2DLI A Y45F *Neutral Neutral 0.067 2DOH X R216H Disease Disease 0.937 2DOH X H242R *Neutral Neutral 0.093 2DOH X R242H Neutral Disease 0.722 2DSC A I123T Neutral Neutral 0.500 2DSC A T123I *Neutral Neutral 0.082 2DSS _ R117T Neutral Neutral 0.265 2DSS _ T117R *Neutral Neutral 0.027 2DSS _ I149V *Neutral Neutral 0.063 2DSS _ V149I Neutral Neutral 0.049 2DSS _ Q187R *Neutral Neutral 0.020 2DSS _ R187Q Neutral Neutral 0.116 2DSS _ M205V Neutral Neutral 0.388 2DSS _ V205M *Neutral Neutral 0.041 2DSS _ I207T *Neutral Neutral 0.100 2DSS _ T207I Neutral Neutral 0.201 2DSS _ A214S *Neutral Neutral 0.049 2DSS _ S214A Neutral Neutral 0.046 2DSS _ D251V Neutral Neutral 0.242 2DSS _ V251D *Neutral Neutral 0.018 2DSS _ E261K Neutral Neutral 0.417 2DSS _ K261E *Neutral Neutral 0.002 2DSS _ I263V Neutral Neutral 0.050 2DSS _ V263I *Neutral Neutral 0.033 2DSS _ R64W Neutral Disease 0.908 2DSS _ W64R *Neutral Neutral 0.001 2DZF _ F11L Neutral Neutral 0.427 2DZF _ L11F *Neutral Neutral 0.001 2DZF _ P333T Neutral Disease 0.623 2DZF _ T333P *Neutral Neutral 0.000 2E56 A P157S Neutral Neutral 0.081 2E56 A S157P *Neutral Neutral 0.000 2E56 A G56R Neutral Disease 0.530 2E56 A R56G *Neutral Neutral 0.000 2E8A A D110E *Neutral Neutral 0.007 2E8A A E110D Neutral Neutral 0.293 2E8A A I95V Neutral Neutral 0.007 2E8A A V95I *Neutral Neutral 0.052 2E9L A D106N Neutral Disease 0.613 2E9L A N106D *Neutral Disease 0.532 2E9L A I172M *Neutral Neutral 0.172 2E9L A M172I Neutral Disease 0.549 2E9L A P213R *Neutral Neutral 0.042 2E9L A R213P Neutral Neutral 0.315 2E9L A C354R Neutral Neutral 0.029 2E9L A R354C *Neutral Disease 0.944 2E9U A Q156R *Neutral Neutral 0.098 2E9U A R156Q Neutral Neutral 0.308 2E9U A E223V Neutral Neutral 0.113 2E9U A V223E *Neutral Neutral 0.062 2E9X A I97V *Neutral Neutral 0.006 2E9X A V97I Neutral Neutral 0.043 2ERY B Q72L Disease Disease 0.717 2ESL A N190S Neutral Neutral 0.133 2ESL A S190N *Neutral Neutral 0.108 2ESL A K86R Neutral Neutral 0.175 2ESL A R86K *Neutral Neutral 0.189 2ETL A S18Y Neutral Neutral 0.288 2ETL A Y18S *Neutral Neutral 0.119 2ETR A N108S *Neutral Neutral 0.196 2ETR A S108N Neutral Neutral 0.208 2ETX B Q1904R *Neutral Neutral 0.073 2ETX B R1904Q Neutral Neutral 0.043 2F3Y A M72T Neutral Neutral 0.195 2F3Y A T72M *Neutral Neutral 0.002 2F8X C E277K *Neutral Neutral 0.019 2F8X C K277E Neutral Disease 0.835 2F8X C K282M *Neutral Neutral 0.004 2F8X C M282K Neutral Disease 0.974 2F8X C D320H Neutral Disease 0.777 2F8X C H320D *Neutral Neutral 0.007 2F8X C I394V Neutral Disease 0.623 2F8X C V394I *Neutral Neutral 0.025 2F8X C Q405R *Neutral Neutral 0.009 2F8X C R405Q Neutral Disease 0.880 2F8X C P411S Neutral Disease 0.898 2F8X C S411P *Neutral Neutral 0.013 2F94 F I325V Neutral Neutral 0.450 2F94 F V325I *Neutral Neutral 0.055 2FD6 A L121P *Neutral Disease 0.739 2FD6 A P121L Neutral Neutral 0.004 2FDV A L110V *Neutral Neutral 0.087 2FDV A V110L Neutral Neutral 0.098 2FDV A F118L Neutral Disease 0.550 2FDV A L118F *Neutral Neutral 0.005 2FDV A L128R *Neutral Neutral 0.000 2FDV A Q128R *Neutral Neutral 0.000 2FDV A R128L Neutral Disease 0.791 2FDV A R128Q Neutral Disease 0.756 2FDV A A131S *Neutral Neutral 0.045 2FDV A S131A Neutral Neutral 0.039 2FDV A H160L *Neutral Neutral 0.018 2FDV A L160H Neutral Disease 0.529 2FDV A E194K *Neutral Neutral 0.055 2FDV A K194E Neutral Neutral 0.030 2FDV A C203R *Neutral Neutral 0.024 2FDV A R203C Neutral Neutral 0.337 2FDV A R203S Neutral Neutral 0.141 2FDV A S203R *Neutral Neutral 0.020 2FDV A P224S *Neutral Neutral 0.288 2FDV A S224P Neutral Neutral 0.014 2FDV A M292V *Neutral Neutral 0.089 2FDV A V292M Neutral Neutral 0.241 2FDV A S294T *Neutral Neutral 0.030 2FDV A T294S Neutral Neutral 0.155 2FDV A M365V *Neutral Neutral 0.128 2FDV A V365M Neutral Neutral 0.366 2FDV A F392Y *Neutral Disease 0.603 2FDV A Y392F Neutral Neutral 0.141 2FDV A D418N *Neutral Neutral 0.086 2FDV A N418D Neutral Neutral 0.001 2FDV A D419E *Neutral Neutral 0.005 2FDV A E419D Neutral Neutral 0.050 2FDV A N438Y Neutral Neutral 0.247 2FDV A Y438N *Neutral Neutral 0.240 2FDV A I471T Neutral Neutral 0.312 2FDV A T471I *Neutral Neutral 0.009 2FDV A K476R Neutral Neutral 0.106 2FDV A R476K *Neutral Neutral 0.096 2FDV A G479V Neutral Disease 0.692 2FDV A V479G *Neutral Neutral 0.001 2FDV A L485R *Neutral Neutral 0.035 2FDV A R485L Neutral Neutral 0.373 2FE2 A K143R Neutral Neutral 0.115 2FE2 A R143K *Neutral Neutral 0.004 2FE2 A A210T Neutral Neutral 0.377 2FE2 A T210A *Neutral Neutral 0.001 2FFU A H245R *Neutral Neutral 0.026 2FFU A R245H Neutral Disease 0.783 2FFU A M554V *Neutral Neutral 0.194 2FFU A V554M Neutral Neutral 0.134 2FFX J A99T Disease Disease 0.536 2FIB A G165R Neutral Disease 0.814 2FIB A R165G *Neutral Neutral 0.001 2FIB A M384V Neutral Disease 0.846 2FIB A V384M *Neutral Neutral 0.000 2FLU X D349N Neutral Neutral 0.311 2FLU X N349D *Neutral Neutral 0.244 2FLU X G364C Disease Disease 0.900 2FLU X G430C Disease Disease 0.982 2FMP A P242R Neutral Neutral 0.407 2FMP A R242P *Neutral Neutral 0.008 2FOY B A142V Neutral Disease 0.845 2FOY B V142A *Neutral Neutral 0.004 2FTU A M72V *Neutral Neutral 0.101 2FTU A V72M Neutral Neutral 0.263 2FV2 C I127T Neutral Disease 0.903 2FV2 C T127I *Neutral Neutral 0.001 2FXM A E846Q Disease Disease 1.000 2FXM A M852T Disease Disease 1.000 2FXM A R858C Disease Disease 1.000 2FXM A R858H Disease Disease 0.997 2FXM A R869C Disease Disease 1.000 2FXM A R869G Disease Disease 1.000 2FXM A R869H Disease Disease 1.000 2FXM A R870C Disease Disease 1.000 2FXM A R870H Disease Disease 1.000 2FXM A M877K Disease Disease 1.000 2FXM A Q882E Disease Disease 1.000 2FXM A E894G Disease Disease 1.000 2FXM A A901G Disease Disease 1.000 2FXM A C905F Disease Disease 1.000 2FXM A D906G Disease Disease 1.000 2FXM A L908V Disease Disease 1.000 2FXM A E921K Disease Disease 1.000 2FXM A E924K Disease Disease 1.000 2FXM A E924Q Disease Disease 1.000 2FXM A E927K Disease Disease 1.000 2FXM A D928N Disease Disease 1.000 2FXM A E930K Disease Disease 1.000 2FXM A E931K Disease Disease 1.000 2FXM A E935K Disease Disease 1.000 2FXM A E949K Disease Disease 1.000 2FXM A D953H Disease Disease 1.000 2FYT A L457V Neutral Disease 0.510 2FYT A V457L *Neutral Neutral 0.010 2FYT A C487S *Neutral Neutral 0.001 2FYT A S487C Neutral Disease 0.789 2FYT A N525S Neutral Neutral 0.208 2FYT A S525N *Neutral Neutral 0.002 2FZE A L162S Neutral Neutral 0.030 2FZE A S162L *Neutral Neutral 0.040 2FZE A I308V *Neutral Neutral 0.001 2FZE A V308I Neutral Neutral 0.024 2FZE A D352E Neutral Neutral 0.009 2FZE A E352D *Neutral Neutral 0.008 2G15 A V1092I Disease Disease 0.671 2G15 A H1094L Disease Neutral 0.433 2G15 A H1094R Disease Neutral 0.272 2G15 A H1094Y Disease Neutral 0.500 2G15 A H1106D Disease Neutral 0.138 2G15 A M1131T Disease Disease 0.765 2G15 A T1173I Disease Neutral 0.074 2G15 A V1188L Disease Neutral 0.492 2G15 A L1195V Disease Disease 0.672 2G15 A V1220I Disease Neutral 0.005 2G15 A D1228H Disease Neutral 0.246 2G15 A D1228N Disease Neutral 0.233 2G15 A Y1230C Disease Neutral 0.358 2G15 A Y1230D Disease Neutral 0.185 2G15 A Y1230H Disease Neutral 0.116 2G15 A K1244R Disease Neutral 0.032 2G15 A M1250I Disease Disease 0.621 2G15 A M1250T Disease Neutral 0.112 2G19 A P317R Disease Disease 0.723 2G19 A R371H Disease Disease 0.846 2G1X A C124F *Neutral Neutral 0.089 2G1X A F124C Neutral Neutral 0.478 2G1X A F219L Neutral Neutral 0.020 2G1X A L219F *Neutral Neutral 0.134 2G1X A I367V Neutral Neutral 0.082 2G1X A V367I *Neutral Neutral 0.008 2G1X A E374K Neutral Neutral 0.012 2G1X A K374E *Neutral Neutral 0.075 2G3R A G1488W Neutral Disease 0.896 2G3R A W1488G *Neutral Neutral 0.000 2G72 B C112R *Neutral Neutral 0.269 2G72 B R112C Neutral Disease 0.854 2G72 B A175T Neutral Disease 0.900 2G72 B T175A *Neutral Neutral 0.002 2G72 B C188S *Neutral Disease 0.601 2G72 B S188C Neutral Neutral 0.032 2G72 B H211L *Neutral Neutral 0.003 2G72 B L211H Neutral Disease 0.962 2G72 B L217Q Neutral Disease 0.943 2G72 B Q217L *Neutral Neutral 0.006 2G72 B H254R *Neutral Neutral 0.102 2G72 B R254H Neutral Disease 0.862 2G72 B R276W *Neutral Neutral 0.230 2G72 B W276R Neutral Disease 0.761 2G72 B A98T *Neutral Neutral 0.142 2G72 B T98A Neutral Disease 0.794 2G76 A R134W Disease Neutral 0.444 2G76 A V260M Disease Disease 0.816 2G7I A D1119G Disease Disease 0.613 2G7I A V1134G Disease Disease 0.844 2G7I A Y1142D Disease Disease 0.845 2G7I A E1143Q *Neutral Neutral 0.099 2G7I A Q1143E Neutral Neutral 0.187 2G7I A W1157R Disease Disease 0.888 2G7I A C1163W Disease Disease 0.860 2G7I A W1183L Disease Disease 0.653 2G7I A W1183R Disease Disease 0.598 2G7I A T1184R Disease Neutral 0.011 2G7I A L1189R Disease Neutral 0.267 2G7I A S1191L Disease Disease 0.531 2G7I A G1194D Disease Disease 0.647 2G7I A V1197A Disease Neutral 0.436 2G7I A E1198A Disease Disease 0.750 2G7I A F1199S Disease Disease 0.890 2G7I A R1210C Disease Neutral 0.145 2G7I A R1215G Disease Disease 0.647 2G7I A R1215Q Disease Neutral 0.402 2G7I A P1226S Disease Disease 0.851 2GCG A Q170R *Neutral Neutral 0.014 2GCG A R170Q Neutral Neutral 0.429 2GCN A D120H Neutral Neutral 0.424 2GCN A H120D *Neutral Neutral 0.000 2GE9 A L100F Disease Disease 0.906 2GE9 A I101M Disease Disease 0.637 2GE9 A R103G Disease Disease 0.951 2GE9 A R19Q Disease Disease 0.951 2GE9 A R19W Disease Disease 0.951 2GE9 A L26P Disease Disease 0.984 2GE9 A G33E Disease Disease 0.969 2GE9 A G33R Disease Disease 0.968 2GE9 A R38G Disease Disease 0.971 2GE9 A R38T Disease Disease 0.967 2GE9 A D39E Disease Disease 0.840 2GE9 A V50A Disease Disease 0.926 2GE9 A Y65S Disease Disease 0.963 2GE9 A L89F Disease Disease 0.944 2GE9 A Y92C Disease Disease 0.969 2GE9 A H93Q Disease Disease 0.930 2GE9 A H95P Disease Disease 0.979 2GE9 A N96Y Disease Disease 0.932 2GE9 A S97F Disease Disease 0.779 2GEG C K102R Neutral Neutral 0.031 2GEG C R102K *Neutral Neutral 0.070 2GEG C P105L Disease Neutral 0.108 2GEG C R124H Disease Neutral 0.107 2GEG C C169Y Disease Neutral 0.258 2GEG C I172N Disease Disease 0.631 2GEG C G178A Disease Disease 0.632 2GEG C D183E Neutral Neutral 0.063 2GEG C E183D *Neutral Neutral 0.010 2GEG C V211L Disease Neutral 0.113 2GEG C I236N Disease Neutral 0.275 2GEG C V237E Disease Neutral 0.322 2GEG C M239K Disease Neutral 0.012 2GEG C L261P Disease Disease 0.707 2GEG C S268T Neutral Neutral 0.034 2GEG C T268S *Neutral Neutral 0.008 2GEG C V281G Disease Neutral 0.246 2GEG C V281L Disease Neutral 0.029 2GEG C M283L Disease Disease 0.526 2GEG C G291C Disease Disease 0.635 2GEG C G291R Disease Disease 0.540 2GEG C G291S Disease Neutral 0.469 2GEG C P30L Disease Neutral 0.374 2GEG C P30Q Disease Neutral 0.348 2GEG C L300F Disease Disease 0.699 2GEG C S301Y Disease Neutral 0.362 2GEG C L317M Disease Neutral 0.093 2GEG C R339H Disease Neutral 0.500 2GEG C R341P Disease Neutral 0.483 2GEG C R341W Disease Neutral 0.327 2GEG C R354C Disease Disease 0.860 2GEG C R354H Disease Disease 0.725 2GEG C R356P Disease Disease 0.607 2GEG C R356Q Disease Neutral 0.461 2GEG C R356W Disease Neutral 0.443 2GEG C A362V Disease Neutral 0.262 2GEG C L363W Disease Neutral 0.311 2GEG C H365Y Disease Disease 0.751 2GEG C E380D Disease Neutral 0.162 2GEG C R408C Disease Disease 0.798 2GEG C G424S Disease Disease 0.767 2GEG C R426H Disease Disease 0.802 2GEG C R435C Disease Disease 0.616 2GEG C P453S Disease Neutral 0.373 2GEG C R479L Disease Neutral 0.185 2GEG C P482S Disease Neutral 0.165 2GEG C R483P Disease Disease 0.601 2GEG C R483Q Disease Neutral 0.367 2GEG C R483W Disease Neutral 0.377 2GEG C N493S Neutral Neutral 0.008 2GEG C S493N *Neutral Neutral 0.003 2GEG C H62L Disease Neutral 0.442 2GEG C G64E Disease Disease 0.706 2GEG C G90V Disease Disease 0.642 2GEG C K98R Neutral Neutral 0.051 2GEG C R98K *Neutral Neutral 0.081 2GF1 A A67T Neutral Neutral 0.271 2GF1 A T67A *Neutral Neutral 0.001 2GFZ A F193S *Neutral Neutral 0.068 2GFZ A S193F Neutral Neutral 0.330 2GFZ A E197K *Neutral Neutral 0.231 2GFZ A K197E Neutral Neutral 0.172 2GGT A P174L Disease Disease 0.910 2GGZ A A118V Neutral Disease 0.831 2GGZ A V118A *Neutral Neutral 0.003 2GGZ A M158V Neutral Neutral 0.274 2GGZ A V158M *Neutral Neutral 0.261 2GGZ A I71V *Neutral Neutral 0.118 2GGZ A V71I Neutral Neutral 0.002 2GGZ A M84V Neutral Neutral 0.262 2GGZ A V84M *Neutral Neutral 0.152 2GMF A I100T Neutral Neutral 0.049 2GMF A T100I *Neutral Neutral 0.016 2GMF A I98T *Neutral Neutral 0.000 2GMF A T98I Neutral Neutral 0.470 2GTG A L39P Disease Disease 0.949 2GTG A C78F Disease Disease 0.901 2GWO C C156Y Neutral Neutral 0.092 2GWO C Y156C *Neutral Neutral 0.276 2GWO C G190R *Neutral Neutral 0.032 2GWO C R190G Neutral Neutral 0.328 2GWO C Q62R *Neutral Neutral 0.050 2GWO C R62Q Neutral Neutral 0.163 2H0D A C18Y Neutral Disease 0.979 2H0D A Y18C *Neutral Neutral 0.003 2H11 A A154T Disease Disease 0.787 2H11 A H179Q *Neutral Neutral 0.025 2H11 A Q179H Neutral Neutral 0.346 2H11 A F180Y *Neutral Neutral 0.073 2H11 A Y180F Neutral Neutral 0.379 2H11 A R215H Disease Neutral 0.192 2H11 A H227Q Disease Neutral 0.239 2H11 A Y240C Disease Disease 0.786 2H11 A L49S Neutral Disease 0.877 2H11 A S49L *Neutral Neutral 0.000 2H11 A A80P Disease Disease 0.896 2H32 A L103S *Neutral Neutral 0.000 2H32 A S103L Neutral Neutral 0.273 2H3N A D57N Neutral Neutral 0.083 2H3N A N57D *Neutral Neutral 0.006 2H3N B P105L Disease Disease 0.750 2H3N B H152R *Neutral Neutral 0.371 2H3N B R152H Neutral Neutral 0.006 2H3N B L83P *Neutral Neutral 0.001 2H3N B P83L Neutral Disease 0.572 2H4D A G139S Neutral Disease 0.505 2H4D A S139G *Neutral Neutral 0.000 2H4D A A233S Neutral Neutral 0.249 2H4D A S233A *Neutral Neutral 0.016 2H4D A S283T Neutral Neutral 0.072 2H4D A T283S *Neutral Neutral 0.016 2H4D A Q391P Disease Disease 0.913 2H57 B G169A Disease Disease 0.866 2H57 B L170W Disease Disease 0.838 2H57 B T31M Disease Disease 0.741 2H57 B T31R Disease Disease 0.814 2H62 A D105G Neutral Disease 0.772 2H62 A G105D *Neutral Neutral 0.122 2H62 C C101R Disease Disease 0.918 2H62 C C107R Disease Disease 0.914 2H62 C Y39D Disease Disease 0.858 2H62 C C59Y Disease Disease 0.953 2H62 D R22H Disease Disease 0.830 2H7J A S47T Neutral Neutral 0.434 2H7J A T47S *Neutral Neutral 0.002 2HA8 A I24V Neutral Neutral 0.055 2HA8 A V24I *Neutral Neutral 0.028 2HAV A C358W *Neutral Neutral 0.017 2HAV A W358C Neutral Disease 0.744 2HAV A I429V *Neutral Neutral 0.000 2HAV A V429I Neutral Disease 0.726 2HAV A A458P Disease Disease 0.949 2HAV A G543V Neutral Neutral 0.217 2HAV A V543G *Neutral Neutral 0.018 2HAV A P570S Neutral Neutral 0.162 2HAV A S570P *Neutral Neutral 0.011 2HAV A P626T *Neutral Neutral 0.010 2HAV A T626P Neutral Neutral 0.295 2HAV A E627K *Neutral Neutral 0.002 2HAV A K627E Neutral Neutral 0.336 2HAV A E652G *Neutral Neutral 0.000 2HAV A G652E Neutral Disease 0.839 2HGL A K87R Neutral Neutral 0.092 2HGL A R87K *Neutral Neutral 0.088 2HGS A L188P Disease Disease 0.965 2HGS A D219A Disease Disease 0.947 2HGS A D219G Disease Disease 0.928 2HGS A Q236R *Neutral Neutral 0.001 2HGS A R236Q Neutral Disease 0.928 2HGS A L254R Disease Disease 0.946 2HGS A A26D Disease Disease 0.940 2HGS A R267W Disease Disease 0.943 2HGS A Y270C Disease Disease 0.953 2HGS A Y270H Disease Disease 0.920 2HGS A R283C Disease Disease 0.962 2HGS A L286Q Disease Disease 0.848 2HGS A R330C Disease Disease 0.859 2HGS A E437K *Neutral Neutral 0.231 2HGS A K437E Neutral Neutral 0.058 2HGS A G464V Disease Disease 0.948 2HGS A D469E Disease Disease 0.946 2HHM A I109V Neutral Neutral 0.367 2HHM A V109I *Neutral Neutral 0.005 2HHN A R-1W Neutral Neutral 0.362 2HHN A W-1R *Neutral Neutral 0.018 2HI4 A D104N Neutral Neutral 0.083 2HI4 A N104D *Neutral Neutral 0.040 2HI4 A F111L *Neutral Neutral 0.060 2HI4 A L111F Neutral Neutral 0.086 2HI4 A E168Q Neutral Disease 0.519 2HI4 A Q168E *Neutral Neutral 0.001 2HI4 A F186L Neutral Neutral 0.422 2HI4 A L186F *Neutral Neutral 0.006 2HI4 A F205V Neutral Disease 0.813 2HI4 A V205F *Neutral Neutral 0.003 2HI4 A C212S *Neutral Neutral 0.018 2HI4 A S212C Neutral Neutral 0.119 2HI4 A R281W Neutral Neutral 0.460 2HI4 A W281R *Neutral Neutral 0.001 2HI4 A R298S *Neutral Neutral 0.030 2HI4 A S298R Neutral Neutral 0.120 2HI4 A G299S Neutral Neutral 0.057 2HI4 A S299G *Neutral Neutral 0.014 2HI4 A I314V Neutral Neutral 0.437 2HI4 A V314I *Neutral Neutral 0.235 2HI4 A D348N Neutral Neutral 0.366 2HI4 A N348D *Neutral Neutral 0.001 2HI4 A Q377R *Neutral Neutral 0.000 2HI4 A R377Q Neutral Disease 0.763 2HI4 A F386I *Neutral Neutral 0.031 2HI4 A I386F Neutral Neutral 0.294 2HI4 A C406Y Neutral Neutral 0.380 2HI4 A Y406C *Neutral Neutral 0.265 2HI4 A P42R Neutral Disease 0.553 2HI4 A R42P *Neutral Neutral 0.000 2HI4 A R431W Neutral Disease 0.729 2HI4 A W431R *Neutral Neutral 0.001 2HI4 A I438T *Neutral Neutral 0.043 2HI4 A T438I Neutral Neutral 0.114 2HI4 A H456R *Neutral Neutral 0.000 2HI4 A R456H Neutral Disease 0.693 2HI4 A R457W Neutral Neutral 0.470 2HI4 A W457R *Neutral Neutral 0.071 2HI4 A G73R Neutral Disease 0.692 2HI4 A R73G *Neutral Neutral 0.000 2HI4 A M83T *Neutral Neutral 0.132 2HI4 A T83M Neutral Neutral 0.135 2HJ8 A N90S *Neutral Neutral 0.001 2HJ8 A S90N Neutral Disease 0.735 2HQQ A G159R *Neutral Neutral 0.020 2HQQ A R159G Neutral Neutral 0.255 2HQQ A G40R Disease Disease 0.915 2HQQ A A43T Disease Disease 0.828 2HQQ A I49V *Neutral Neutral 0.003 2HQQ A V49I Neutral Disease 0.601 2HRB A P131S Neutral Neutral 0.143 2HRB A S131P *Neutral Neutral 0.097 2HRB A L235M *Neutral Neutral 0.000 2HRB A M235L Neutral Neutral 0.100 2HRB A M244V *Neutral Neutral 0.052 2HRB A V244M Neutral Disease 0.506 2HRB A L84V Neutral Neutral 0.414 2HRB A V84L *Neutral Neutral 0.012 2HRB A I93V *Neutral Neutral 0.085 2HRB A V93I Neutral Neutral 0.003 2HT9 B E55K *Neutral Neutral 0.128 2HT9 B K55E Neutral Neutral 0.500 2HYE C K614R Neutral Neutral 0.281 2HYE C R614K *Neutral Neutral 0.375 2HYE C K644R Neutral Neutral 0.148 2HYE C R644K *Neutral Neutral 0.044 2HYV A L97V *Neutral Neutral 0.096 2HYV A V97L Neutral Neutral 0.227 2HZI A K247R Neutral Disease 0.629 2HZI A R247K *Neutral Disease 0.540 2I3B A E105G *Neutral Neutral 0.009 2I3B A G105E Neutral Disease 0.647 2I3Y A L85V Neutral Disease 0.750 2I3Y A V85L *Neutral Neutral 0.000 2I50 A H124Q *Neutral Neutral 0.214 2I50 A Q124H Neutral Neutral 0.127 2I7D A L68P *Neutral Neutral 0.008 2I7D A P68L Neutral Neutral 0.411 2I8H _ A509S Neutral Disease 0.682 2I8H _ S509A *Neutral Neutral 0.001 2IB8 D G152A Disease Disease 0.892 2IB8 D N158D Disease Neutral 0.273 2IB8 D G183R Disease Disease 0.818 2IB8 D T297M Disease Disease 0.589 2IB8 D A301P Disease Disease 0.906 2IB8 D I312T Disease Disease 0.737 2IB8 D A333P Disease Disease 0.845 2IB8 D G379V Disease Disease 0.858 2IB8 D A380T Disease Disease 0.837 2IB8 D N93S Disease Disease 0.611 2IC1 A I45T *Neutral Neutral 0.050 2IC1 A T45I Neutral Neutral 0.056 2ICC A R89W Neutral Disease 0.769 2ICC A W89R *Neutral Neutral 0.001 2ID5 B F144S *Neutral Neutral 0.248 2ID5 B S144F Neutral Disease 0.743 2IE4 C A52V *Neutral Neutral 0.145 2IE4 C V52A Neutral Disease 0.841 2IFG A L213P Disease Disease 0.910 2IFG A M237T *Neutral Neutral 0.013 2IFG A T237M Neutral Neutral 0.215 2IFG A G238V *Neutral Neutral 0.026 2IFG A V238G Neutral Neutral 0.166 2IFG A G260R *Neutral Neutral 0.260 2IFG A R260G Neutral Neutral 0.011 2IFG A Q80R Neutral Neutral 0.492 2IFG A R80Q *Neutral Neutral 0.020 2IFG A R85S Neutral Neutral 0.123 2IFG A S85R *Neutral Neutral 0.043 2IFG A L93P Disease Disease 0.947 2IIL _ K374T Neutral Neutral 0.071 2IIL _ T374K *Neutral Neutral 0.002 2IK5 _ C240R *Neutral Neutral 0.027 2IK5 _ R240C Neutral Neutral 0.430 2IK5 _ A99S Neutral Neutral 0.321 2IK5 _ S99A *Neutral Neutral 0.023 2IK8 D H137R *Neutral Neutral 0.004 2IK8 D R137H Neutral Disease 0.805 2IKO A G146R Neutral Disease 0.559 2IKO A R146G *Neutral Neutral 0.003 2IKO A R159K Disease Neutral 0.249 2IKO A D33N Disease Disease 0.816 2IKO A K89Q *Neutral Neutral 0.026 2IKO A Q89K Neutral Neutral 0.123 2IMT A A28V Neutral Disease 0.890 2IMT A V28A *Neutral Neutral 0.004 2IMT A H42R *Neutral Neutral 0.007 2IMT A R42H Neutral Disease 0.961 2IMT A R69S *Neutral Neutral 0.008 2IMT A S69R Neutral Disease 0.868 2IO1 D P38S Neutral Neutral 0.465 2IO1 D S38P *Neutral Neutral 0.028 2IPD _ P360S Neutral Disease 0.799 2IPD _ S360P *Neutral Neutral 0.001 2IPD _ I46R Neutral Neutral 0.361 2IPD _ I46T Neutral Neutral 0.399 2IPD _ R46I *Neutral Neutral 0.165 2IPD _ T46I *Neutral Neutral 0.079 2IPD _ I55V Neutral Neutral 0.037 2IPD _ V55I *Neutral Neutral 0.104 2IPE _ L148P Neutral Disease 0.778 2IPE _ P148L *Neutral Neutral 0.000 2IPE _ E19K Neutral Disease 0.699 2IPE _ K19E *Neutral Neutral 0.001 2IPE _ I26T *Neutral Neutral 0.008 2IPE _ T26I Neutral Disease 0.584 2IZ3 A R32W *Neutral Neutral 0.002 2IZ3 A W32R Neutral Disease 0.791 2IZ3 A Q33R Neutral Neutral 0.038 2IZ3 A R33Q *Neutral Neutral 0.228 2IZ3 A I5M Neutral Neutral 0.443 2IZ3 A M5I *Neutral Neutral 0.005 2IZ3 A A60D *Neutral Neutral 0.001 2IZ3 A D60A Neutral Disease 0.885 2IZ3 A I67T Neutral Disease 0.797 2IZ3 A T67I *Neutral Neutral 0.001 2IZ3 A E71G Neutral Disease 0.666 2IZ3 A G71E *Neutral Neutral 0.001 2IZ3 A D72G Neutral Neutral 0.319 2IZ3 A G72D *Neutral Neutral 0.013 2IZ3 A L78V *Neutral Neutral 0.000 2IZ3 A V78L Neutral Disease 0.873 2J4O A D224E Neutral Neutral 0.475 2J4O A E224D *Neutral Neutral 0.001 2J4Z B M373V Neutral Neutral 0.434 2J4Z B V373M *Neutral Neutral 0.126 2J8J A F283L Disease Disease 0.838 2J8J A F290I *Neutral Neutral 0.014 2J8J A I290F Neutral Disease 0.823 2J8J A L302P Disease Disease 0.877 2J8J A T304I Disease Disease 0.788 2J8J A R308C Disease Disease 0.952 2J8J A C321F Neutral Disease 0.908 2J8J A F321C *Neutral Neutral 0.002 2J8J A E323K Disease Disease 0.769 2JBM A A160V Neutral Disease 0.607 2JBM A V160A *Neutral Neutral 0.500 2JBM A A197T Neutral Neutral 0.092 2JBM A T197A *Neutral Neutral 0.127 2JGX A Q400K Disease Disease 0.528 2JGX A H402Y *Neutral Neutral 0.256 2JGX A Y402H Neutral Disease 0.507 2JGX A C431S Disease Disease 0.939 2JIF A G209S *Neutral Neutral 0.219 2JIF A S209G Neutral Disease 0.686 2JIF A L255F Disease Disease 0.757 2JIF A I316V Neutral Neutral 0.246 2JIF A V316I *Neutral Neutral 0.466 2JIF A E376G Neutral Disease 0.758 2JIF A G376E *Neutral Neutral 0.016 2JJT B D10E Neutral Neutral 0.001 2JJT B E10D *Neutral Neutral 0.333 2JJT B F103L Neutral Neutral 0.102 2JJT B L103F *Neutral Neutral 0.010 2JJT B L14S *Neutral Neutral 0.001 2JJT B S14L Neutral Neutral 0.106 2JJT B S20T Neutral Neutral 0.004 2JJT B T20S *Neutral Neutral 0.038 2JJT B I22T Neutral Neutral 0.001 2JJT B T22I *Neutral Neutral 0.489 2JJT B H24R Neutral Neutral 0.047 2JJT B R24H *Neutral Neutral 0.109 2JJT B A27V *Neutral Neutral 0.003 2JJT B V27A Neutral Disease 0.629 2JJT B I31N Neutral Neutral 0.260 2JJT B N31I *Neutral Neutral 0.003 2JJT B R38W *Neutral Neutral 0.000 2JJT B W38R Neutral Disease 0.897 2JJT B A45G Neutral Neutral 0.002 2JJT B G45A *Neutral Neutral 0.235 2JJT B E47K Neutral Disease 0.578 2JJT B K47E *Neutral Neutral 0.002 2JJT B H51N *Neutral Neutral 0.025 2JJT B N51H Neutral Neutral 0.139 2JJT B D65E *Neutral Neutral 0.293 2JJT B E65D Neutral Neutral 0.001 2JJT B L66S *Neutral Neutral 0.016 2JJT B S66L Neutral Neutral 0.119 2JJT B C77S *Neutral Neutral 0.269 2JJT B R77S *Neutral Disease 0.652 2JJT B S77C Neutral Neutral 0.301 2JJT B S77R Neutral Neutral 0.003 2JJT B G79S *Neutral Neutral 0.000 2JJT B S79G Neutral Disease 0.625 2JJT B Q95R *Neutral Neutral 0.078 2JJT B R95Q Neutral Neutral 0.008 2JJV B I22T *Neutral Neutral 0.001 2JJV B T22I Neutral Disease 0.619 2JK2 B E104D Disease Disease 0.911 2JK2 B V154M Disease Disease 0.759 2JK2 B I170V Disease Disease 0.897 2JK2 B V231M Disease Disease 0.926 2JK2 B F240L Disease Disease 0.946 2JK2 B C41Y Disease Disease 0.944 2JK2 B G72A Disease Disease 0.907 2JQ3 A K58E Disease Neutral 0.251 2JQH A I61M Neutral Disease 0.965 2JQH A M61I *Neutral Neutral 0.003 2JSD A D139N Neutral Disease 0.699 2JSD A N139D *Neutral Neutral 0.034 2JSD A I169L Neutral Neutral 0.483 2JSD A L169I *Neutral Neutral 0.002 2JUJ A I54V *Neutral Neutral 0.001 2JUJ A V54I Neutral Neutral 0.257 2JW6 A T526N Disease Disease 0.779 2JW6 A R530L Disease Disease 0.869 2JW6 A Q542H Disease Disease 0.906 2JWA A I54V Neutral Disease 0.876 2JWA A V54I *Neutral Neutral 0.000 2JWA A I55V Neutral Disease 0.887 2JWA A V55I *Neutral Neutral 0.000 2JX3 A A63V *Neutral Neutral 0.134 2JX3 A V63A Neutral Neutral 0.117 2JXC B P307S *Neutral Neutral 0.075 2JXC B S307P Neutral Neutral 0.010 2K1M A G4R Disease Disease 0.981 2K1M A T58A Disease Neutral 0.319 2KAX A D54G Neutral Neutral 0.265 2KAX A G54D *Neutral Neutral 0.259 2KC3 A E13K Disease Disease 0.834 2KC3 A E3K Neutral Disease 0.856 2KC3 A K3E *Neutral Neutral 0.000 2NMO A K183R *Neutral Neutral 0.047 2NMO A R183K Neutral Neutral 0.108 2NNJ A K139R *Neutral Neutral 0.020 2NNJ A R139K Neutral Neutral 0.115 2NNJ A I244V Neutral Neutral 0.095 2NNJ A V244I *Neutral Neutral 0.024 2NNJ A I264M Neutral Neutral 0.418 2NNJ A M264I *Neutral Neutral 0.022 2NNJ A F269I *Neutral Neutral 0.024 2NNJ A I269F Neutral Neutral 0.305 2NNJ A L390S Neutral Neutral 0.379 2NNJ A S390L *Neutral Neutral 0.370 2NNJ A K399R Neutral Neutral 0.065 2NNJ A R399K *Neutral Neutral 0.016 2NPT D I110V Neutral Neutral 0.055 2NPT D V110I *Neutral Neutral 0.047 2NTE A C645R Neutral Neutral 0.344 2NTE A R645C *Neutral Disease 0.767 2NTE A C658R *Neutral Neutral 0.419 2NTE A R658C Neutral Disease 0.970 2NTE A V695L Disease Disease 0.937 2NTE A F728S *Neutral Neutral 0.010 2NTE A S728F Neutral Disease 0.971 2NTE A S761N Disease Disease 0.937 2NY1 B E1166K *Neutral Neutral 0.000 2NY1 B K1166E Neutral Neutral 0.178 2O07 B L149V Neutral Neutral 0.012 2O07 B V149L *Neutral Neutral 0.206 2O10 A L44P Disease Disease 0.979 2O10 A C58G Disease Disease 0.962 2O39 C Q25R *Neutral Neutral 0.047 2O39 C R25Q Neutral Neutral 0.260 2O4H A D114E Disease Disease 0.934 2O4H A D114Y Disease Disease 0.943 2O4H A G123E Disease Disease 0.962 2O4H A I143T Disease Disease 0.825 2O4H A C152R Disease Disease 0.787 2O4H A C152W Disease Disease 0.804 2O4H A C152Y Disease Disease 0.785 2O4H A I16T Disease Disease 0.850 2O4H A R168C Disease Disease 0.773 2O4H A R168H Disease Disease 0.850 2O4H A P181T Disease Disease 0.835 2O4H A P183H Disease Disease 0.697 2O4H A V186F Disease Disease 0.697 2O4H A M195R Disease Disease 0.865 2O4H A H21P Disease Disease 0.985 2O4H A Y231C Disease Disease 0.925 2O4H A E24G Disease Disease 0.937 2O4H A H244R Disease Disease 0.917 2O4H A D249V Disease Disease 0.623 2O4H A G27R Disease Disease 0.955 2O4H A G274R Disease Disease 0.778 2O4H A P280L Disease Disease 0.920 2O4H A P280S Disease Disease 0.910 2O4H A E285A Disease Disease 0.956 2O4H A A287T Disease Disease 0.911 2O4H A F295S Disease Disease 0.870 2O4H A A305E Disease Disease 0.759 2O4H A C310G Neutral Disease 0.927 2O4H A G310C *Neutral Neutral 0.001 2O4H A A57T Disease Disease 0.932 2O4H A D68A Disease Disease 0.952 2O8J B F1165Y *Neutral Neutral 0.015 2O8J B Y1165F Neutral Neutral 0.049 2OAT A R154L Disease Disease 0.932 2OAT A R180T Disease Disease 0.878 2OAT A A226V Disease Disease 0.870 2OAT A P241L Disease Disease 0.693 2OAT A Y245C Disease Disease 0.812 2OAT A R250P Disease Disease 0.931 2OAT A T267I Disease Disease 0.785 2OAT A A270P Disease Disease 0.829 2OAT A R271K Disease Disease 0.880 2OAT A H319Y Disease Disease 0.878 2OAT A V332M Disease Disease 0.787 2OAT A G353D Disease Disease 0.885 2OAT A G375A Disease Disease 0.926 2OAT A C394R Disease Disease 0.716 2OAT A L402P Disease Disease 0.867 2OAT A P417L Disease Disease 0.895 2OAT A F437L *Neutral Neutral 0.012 2OAT A L437F Neutral Neutral 0.157 2OAT A N54K Disease Neutral 0.500 2OAT A Y55H Disease Disease 0.524 2OAT A N89K Disease Disease 0.750 2OAT A Q90E Disease Disease 0.806 2OAT A C93F Disease Disease 0.586 2OBI A A93T Disease Neutral 0.335 2OF2 A A353V Disease Neutral 0.318 2OF2 A P447L Disease Neutral 0.096 2OK3 A D146E Neutral Neutral 0.190 2OK3 A E146D *Neutral Neutral 0.007 2OME A D47E *Neutral Neutral 0.007 2OME A E47D Neutral Neutral 0.310 2OSA A E313K Disease Neutral 0.043 2OUO A A371G Neutral Neutral 0.226 2OUO A G371A *Neutral Neutral 0.009 2OVQ B R2465C Disease Disease 0.963 2OVQ B R2505L Disease Disease 0.961 2OVQ B G2668S *Neutral Neutral 0.091 2OVQ B S2668G Neutral Neutral 0.345 2OZB A N19T *Neutral Neutral 0.014 2OZB A T19N Neutral Neutral 0.269 2P0H A A370S *Neutral Neutral 0.032 2P0H A S370A Neutral Neutral 0.085 2P0R A A102V Neutral Disease 0.812 2P0R A V102A *Neutral Neutral 0.002 2P0R A R122S *Neutral Neutral 0.012 2P0R A S122R Neutral Neutral 0.378 2P0R A D164N Neutral Neutral 0.201 2P0R A N164D *Neutral Neutral 0.042 2P0R A I234T Neutral Neutral 0.425 2P0R A T234I *Neutral Neutral 0.012 2P0R A A239T Neutral Neutral 0.082 2P0R A T239A *Neutral Neutral 0.008 2P0R A R277W Neutral Disease 0.871 2P0R A W277R *Neutral Neutral 0.003 2P0R A K322Q Neutral Neutral 0.052 2P0R A Q322K *Neutral Neutral 0.143 2P0R A H327Q Neutral Neutral 0.354 2P0R A Q327H *Neutral Neutral 0.051 2P39 A S71G Disease Disease 0.755 2P54 A A227V *Neutral Neutral 0.103 2P54 A V227A Neutral Neutral 0.070 2P54 A A268V Neutral Neutral 0.441 2P54 A V268A *Neutral Neutral 0.071 2P54 A D304N Neutral Disease 0.921 2P54 A N304D *Neutral Neutral 0.000 2P54 A G395R Neutral Neutral 0.249 2P54 A R395G *Neutral Neutral 0.367 2P54 A R409T Neutral Disease 0.782 2P54 A T409R *Neutral Neutral 0.037 2P85 A Q101R *Neutral Neutral 0.000 2P85 A R101Q Neutral Disease 0.832 2P85 A D158E Neutral Neutral 0.014 2P85 A E158D *Neutral Neutral 0.136 2P85 A C257R *Neutral Neutral 0.018 2P85 A R257C Neutral Neutral 0.256 2P85 A L323V *Neutral Neutral 0.007 2P85 A V323L Neutral Disease 0.708 2P85 A F453Y Neutral Disease 0.573 2P85 A Y453F *Neutral Neutral 0.011 2P85 A C494R *Neutral Neutral 0.000 2P85 A R494C Neutral Disease 0.744 2PET A I165V *Neutral Neutral 0.069 2PET A V165I Neutral Neutral 0.035 2PET A K173M *Neutral Neutral 0.046 2PET A M173K Neutral Disease 0.701 2PET A H46R *Neutral Neutral 0.001 2PET A R46H Neutral Disease 0.819 2PI0 B F107Y *Neutral Neutral 0.001 2PI0 B Y107F Neutral Disease 0.912 2PI0 B Q96R *Neutral Neutral 0.030 2PI0 B R96Q Neutral Disease 0.646 2PLA A I124V Disease Neutral 0.451 2PLA A F178L *Neutral Neutral 0.070 2PLA A L178F Neutral Neutral 0.215 2PLA A R273C Disease Disease 0.956 2PLA A A280V Disease Disease 0.551 2PLA A E83K Disease Neutral 0.272 2PNO A Q142R *Neutral Neutral 0.016 2PNO A R142Q Neutral Neutral 0.329 2PSN C K176N *Neutral Disease 0.794 2PSN C N176K Neutral Disease 0.960 2PSN C P324Q Neutral Disease 0.971 2PSN C Q324P *Neutral Neutral 0.230 2PSX A D102N Neutral Disease 0.766 2PSX A N102D *Neutral Neutral 0.001 2PX9 A L307R Neutral Disease 0.738 2PX9 A R307L *Neutral Neutral 0.007 2Q6W B C11R *Neutral Neutral 0.022 2Q6W B R11C Neutral Neutral 0.087 2Q6W B A73G *Neutral Neutral 0.223 2Q6W B G73A Neutral Neutral 0.001 2Q6W B A85V *Neutral Neutral 0.001 2Q6W B V85A Neutral Neutral 0.302 2Q8R E E34K *Neutral Neutral 0.005 2Q8R E K34E Neutral Neutral 0.354 2QC8 A R324C Disease Disease 0.970 2QC8 A R341C Disease Disease 0.972 2QD4 A Q139L Disease Disease 0.940 2QD4 A S151P Disease Disease 0.858 2QD4 A E178K Disease Neutral 0.309 2QD4 A L182R Disease Disease 0.794 2QD4 A I186T Disease Disease 0.860 2QD4 A Y191H Disease Disease 0.914 2QD4 A P192T Disease Disease 0.945 2QD4 A C236Y Disease Disease 0.713 2QD4 A F260L Disease Disease 0.919 2QD4 A S264L Disease Disease 0.937 2QD4 A M267I Disease Disease 0.722 2QD4 A T283I Disease Disease 0.946 2QD4 A M288K Disease Disease 0.863 2QD4 A P334L Disease Disease 0.856 2QD4 A V362G Disease Neutral 0.072 2QD4 A K379N Disease Neutral 0.463 2QD4 A H386P Disease Disease 0.832 2QD4 A C406S Disease Disease 0.909 2QD4 A C406Y Disease Disease 0.935 2QD4 A F417S Disease Disease 0.911 2QD4 A I71K Disease Disease 0.941 2QD4 A Q96R *Neutral Neutral 0.060 2QD4 A R96Q Neutral Disease 0.718 2QIC A C215S Disease Disease 0.920 2QIC A N216S Disease Disease 0.602 2QJ2 B I1153S *Neutral Neutral 0.013 2QJ2 B S1153I Neutral Neutral 0.335 2QJF B F270L *Neutral Neutral 0.027 2QJF B L270F Neutral Disease 0.848 2QJF B L587S *Neutral Neutral 0.000 2QJF B S587L Neutral Disease 0.838 2R0L A H111CR *Neutral Neutral 0.019 2R0L A R111CH Neutral Neutral 0.289 2R0L A Q241R *Neutral Neutral 0.281 2R0L A R241Q Neutral Neutral 0.309 2RA4 A N6S Neutral Neutral 0.014 2RA4 A S6N *Neutral Neutral 0.003 2RCW A A101V *Neutral Neutral 0.185 2RCW A V101A Neutral Disease 0.673 2RCW A K279R Neutral Neutral 0.199 2RCW A R279K *Neutral Neutral 0.047 2RE9 A F39L Neutral Neutral 0.029 2RE9 A L39F *Neutral Neutral 0.031 2RFX A L103V *Neutral Neutral 0.032 2RFX A V103L Neutral Neutral 0.134 2RFX A H113Y Neutral Neutral 0.005 2RFX A Y113H *Neutral Disease 0.629 2RFX A D114N Neutral Neutral 0.288 2RFX A N114D *Neutral Neutral 0.152 2RFX A S116Y Neutral Neutral 0.053 2RFX A Y116S *Neutral Disease 0.663 2RFX A L156R Neutral Neutral 0.117 2RFX A R156L *Neutral Neutral 0.308 2RFX A R97V *Neutral Neutral 0.474 2RFX A V97R Neutral Neutral 0.035 2RIQ A I334V *Neutral Neutral 0.017 2RIQ A V334I Neutral Neutral 0.124 2RLP A R127L Disease Disease 0.897 2RLP A I62V *Neutral Disease 0.563 2RLP A V62I Neutral Neutral 0.010 2RLP A R78G Disease Disease 0.500 2RO1 A M794T *Neutral Disease 0.632 2RO1 A T794M Neutral Disease 0.632 2UYY A H459Q *Neutral Neutral 0.234 2UYY A Q459H Neutral Neutral 0.409 2UYY A C531Y *Neutral Neutral 0.039 2UYY A Y531C Neutral Disease 0.943 2V5E B I134M Disease Disease 0.764 2V5E B D73N Disease Disease 0.717 2V5E B T77S Disease Disease 0.844 2V5Q A F261L *Neutral Neutral 0.178 2V5Q A L261F Neutral Neutral 0.202 2V5Q A D297N *Neutral Neutral 0.113 2V5Q A N297D Neutral Neutral 0.050 2V70 A P636S *Neutral Neutral 0.135 2V70 A S636P Neutral Disease 0.814 2V77 A H166R Neutral Neutral 0.093 2V77 A R166H *Neutral Neutral 0.252 2V77 A A98T Neutral Neutral 0.162 2V77 A T98A *Neutral Neutral 0.042 2VAF A R1014Q Disease Disease 0.852 2VAF A A1047T *Neutral Neutral 0.284 2VAF A T1047A Neutral Neutral 0.008 2VAF A M1057V *Neutral Neutral 0.005 2VAF A V1057M Neutral Neutral 0.403 2VAF A L1148H Disease Disease 0.836 2VAF A D1288H Disease Disease 0.852 2VCV A I71L Neutral Disease 0.817 2VCV A L71I *Neutral Neutral 0.000 2VCV A D73N *Neutral Neutral 0.123 2VCV A N73D Neutral Disease 0.542 2VCY A K227R *Neutral Neutral 0.022 2VCY A R227K Neutral Neutral 0.357 2VCY A L258R *Neutral Neutral 0.033 2VCY A R258L Neutral Disease 0.681 2VCY A F96L *Neutral Neutral 0.167 2VCY A L96F Neutral Neutral 0.247 2VDR A A108V Disease Disease 0.866 2VDR A C130W Disease Disease 0.828 2VDR A Y143H Disease Disease 0.643 2VDR A P145A Disease Disease 0.633 2VDR A P145L Disease Disease 0.649 2VDR A F171C Disease Disease 0.852 2VDR A T176I Disease Disease 0.718 2VDR A L183P Disease Disease 0.916 2VDR A F191L Disease Disease 0.714 2VDR A G236E Disease Disease 0.939 2VDR A G242D Disease Disease 0.817 2VDR A A282G *Neutral Neutral 0.000 2VDR A G282A Neutral Disease 0.834 2VDR A F289S Disease Disease 0.939 2VDR A V298F Disease Disease 0.619 2VDR A E324K Disease Disease 0.825 2VDR A R327H Disease Disease 0.816 2VDR A G349D Disease Disease 0.842 2VDR A I374T Disease Disease 0.615 2VDR A G381R Disease Disease 0.832 2VDR A G418D Disease Disease 0.918 2VDR A L55P Disease Disease 0.689 2VDR A I9T *Neutral Neutral 0.093 2VDR A T9I Neutral Neutral 0.253 2VGB A M107T Disease Disease 0.877 2VGB A G111R Disease Disease 0.946 2VGB A A115P Disease Disease 0.938 2VGB A S120F Disease Disease 0.888 2VGB A S130Y Disease Disease 0.763 2VGB A V134D Disease Disease 0.884 2VGB A I153T Disease Disease 0.895 2VGB A A154T Disease Disease 0.807 2VGB A L155P Disease Disease 0.916 2VGB A G159V Disease Disease 0.887 2VGB A R163C Disease Disease 0.961 2VGB A R163L Disease Disease 0.947 2VGB A G165V Disease Disease 0.905 2VGB A E172Q Disease Neutral 0.195 2VGB A I219T Disease Disease 0.764 2VGB A G222A Disease Disease 0.928 2VGB A G263R Disease Disease 0.648 2VGB A G263W Disease Disease 0.659 2VGB A L272V Disease Disease 0.891 2VGB A G275R Disease Disease 0.929 2VGB A D281N Disease Disease 0.873 2VGB A F287V Disease Disease 0.903 2VGB A V288L Disease Disease 0.801 2VGB A D293N Disease Disease 0.876 2VGB A A295V Disease Neutral 0.463 2VGB A I310N Disease Disease 0.812 2VGB A I314T Disease Disease 0.903 2VGB A E315K Disease Disease 0.932 2VGB A V320L Disease Disease 0.551 2VGB A D331E Disease Disease 0.884 2VGB A D331N Disease Disease 0.822 2VGB A G332S Disease Disease 0.896 2VGB A V335M Disease Disease 0.909 2VGB A A336S Disease Disease 0.911 2VGB A R337P Disease Disease 0.979 2VGB A R337Q Disease Disease 0.949 2VGB A D339H Disease Disease 0.873 2VGB A G341A Disease Disease 0.889 2VGB A G341D Disease Disease 0.960 2VGB A I342F Disease Disease 0.818 2VGB A K348N Disease Neutral 0.369 2VGB A A352D Disease Disease 0.700 2VGB A I357T Disease Disease 0.855 2VGB A G358E Disease Neutral 0.470 2VGB A R359C Disease Disease 0.831 2VGB A R359H Disease Disease 0.688 2VGB A N361D Disease Disease 0.887 2VGB A G364D Disease Disease 0.819 2VGB A V368F Disease Disease 0.937 2VGB A L374P Disease Disease 0.930 2VGB A S376I Disease Disease 0.838 2VGB A T384M Disease Disease 0.735 2VGB A R385W Disease Disease 0.770 2VGB A E387G Disease Disease 0.770 2VGB A D390N Disease Disease 0.869 2VGB A A392T Disease Disease 0.880 2VGB A N393K Disease Disease 0.917 2VGB A N393S Disease Disease 0.847 2VGB A A394D Disease Disease 0.967 2VGB A A394V Disease Disease 0.941 2VGB A T408A Disease Disease 0.865 2VGB A T408I Disease Disease 0.862 2VGB A Q421K Disease Disease 0.909 2VGB A R426Q Disease Disease 0.740 2VGB A R426W Disease Disease 0.834 2VGB A E427A Disease Disease 0.605 2VGB A E427D Disease Disease 0.601 2VGB A A431T Disease Neutral 0.494 2VGB A G458D Disease Disease 0.748 2VGB A A459V Disease Disease 0.835 2VGB A V460M Disease Disease 0.539 2VGB A A468G Disease Disease 0.838 2VGB A A468V Disease Disease 0.773 2VGB A T477A Disease Neutral 0.392 2VGB A R479H Disease Neutral 0.299 2VGB A S485F Disease Disease 0.894 2VGB A R486W Disease Disease 0.836 2VGB A R488Q Disease Disease 0.914 2VGB A R490W Disease Disease 0.692 2VGB A A495T Disease Disease 0.883 2VGB A A495V Disease Disease 0.851 2VGB A R498C Disease Disease 0.781 2VGB A R498H Disease Disease 0.600 2VGB A R504L Disease Disease 0.946 2VGB A I506V *Neutral Disease 0.565 2VGB A V506I Neutral Disease 0.675 2VGB A R510Q Disease Disease 0.875 2VGB A G511R Disease Disease 0.931 2VGB A R531C Disease Disease 0.710 2VGB A R532Q Disease Disease 0.669 2VGB A R532W Disease Disease 0.749 2VGB A V552M Disease Disease 0.841 2VGB A G557A Disease Disease 0.875 2VGB A R559G Disease Disease 0.701 2VGB A N566K Disease Disease 0.886 2VGB A R569Q Disease Disease 0.857 2VGB A L73P Disease Disease 0.648 2VGB A S80P Disease Disease 0.745 2VGB A R86P Disease Disease 0.955 2VGB A I90N Disease Disease 0.886 2VGB A G95R Disease Disease 0.927 2VJ2 B C187S Disease Disease 0.847 2VJ2 B C187Y Disease Disease 0.855 2VJ2 B C220F Disease Disease 0.902 2VJ2 B W224C Disease Disease 0.940 2VJ2 B C229G Disease Disease 0.947 2VJ2 B C229Y Disease Disease 0.953 2VJ2 B R252G Disease Disease 0.732 2VJ2 B G256S Disease Disease 0.904 2VJ2 B P269L Disease Disease 0.759 2VJ2 B C271R Disease Disease 0.918 2VJ2 B G274D Disease Disease 0.941 2VJ2 B C284F Disease Disease 0.904 2VJ2 B W288C Disease Disease 0.924 2VKQ A L131P Disease Disease 0.950 2VKQ A N179S Disease Disease 0.861 2VKQ A G230R Disease Disease 0.820 2VKQ A D87V Disease Disease 0.755 2VM8 A A118T Neutral Neutral 0.305 2VM8 A T118A *Neutral Neutral 0.032 2VNS A A184T Neutral Neutral 0.143 2VNS A T184A *Neutral Neutral 0.060 2VOO A P48S Neutral Neutral 0.405 2VOO A S48P *Neutral Neutral 0.022 2VRG A D129E Disease Disease 0.750 2VRG A I136T Disease Disease 0.726 2VRW A I108T *Neutral Neutral 0.264 2VRW A T108I Neutral Neutral 0.355 2VRW A K130R Neutral Neutral 0.025 2VRW A R130K *Neutral Neutral 0.098 2VRW A E133K *Neutral Neutral 0.014 2VRW A K133E Neutral Neutral 0.214 2VRW A I135T *Neutral Neutral 0.067 2VRW A T135I Neutral Neutral 0.166 2VRW A D26N *Neutral Neutral 0.014 2VRW A N26D Neutral Neutral 0.108 2VRW A F28L Neutral Disease 0.763 2VRW A L28F *Neutral Neutral 0.000 2VRW A A59T Neutral Disease 0.798 2VRW A T59A *Neutral Neutral 0.000 2VRW A D63G Neutral Neutral 0.333 2VRW A G63D *Neutral Neutral 0.033 2VRW A G93V *Neutral Neutral 0.034 2VRW A I93V *Neutral Neutral 0.017 2VRW A V93G Neutral Disease 0.752 2VRW A V93I Neutral Neutral 0.250 2VSW A M23T *Neutral Neutral 0.002 2VSW A T23M Neutral Neutral 0.131 2VX2 A A151T *Neutral Neutral 0.380 2VX2 A T151A Neutral Neutral 0.356 2VX2 A D162N Neutral Disease 0.780 2VX2 A N162D *Neutral Neutral 0.000 2VX2 A A69T *Neutral Disease 0.597 2VX2 A T69A Neutral Neutral 0.000 2VXP A V505D Disease Disease 0.746 2VXP A L509R Disease Disease 0.683 2VXP A L518P Disease Disease 0.948 2VXP A L518R Disease Disease 0.881 2VXP A L527R Disease Disease 0.865 2VXP A T538R Disease Disease 0.925 2VXP A F540S Disease Disease 0.927 2VXP A A546D Disease Disease 0.887 2VXP A A546T Disease Disease 0.829 2VXP A P551Q Disease Disease 0.598 2VXP A R555Q Disease Neutral 0.408 2VXP A R555W Disease Neutral 0.489 2VXP A L569R Disease Disease 0.833 2VXP A H572R Disease Disease 0.885 2VXP A N622K Disease Disease 0.945 2VXP A G623D Disease Disease 0.939 2VXP A H626P Disease Disease 0.966 2VXP A H626R Disease Disease 0.900 2W08 A E136G Neutral Disease 0.587 2W08 A G136E *Neutral Neutral 0.003 2W08 A G139S *Neutral Neutral 0.012 2W08 A S139G Neutral Neutral 0.385 2W8N A G176R Disease Disease 0.982 2W8N A H180Y Neutral Disease 0.775 2W8N A Y180H *Neutral Disease 0.758 2W8N A L182P *Neutral Neutral 0.086 2W8N A P182L Neutral Disease 0.778 2W8N A C223Y Disease Disease 0.994 2W8N A T233M Disease Disease 0.924 2W8N A N255S Disease Disease 0.977 2W8N A G268E Disease Disease 0.994 2W8N A N335K Disease Disease 0.973 2W8N A P382L Disease Disease 0.976 2W8N A P382Q Disease Disease 0.971 2W8N A I406V *Neutral Neutral 0.192 2W8N A V406I Neutral Disease 0.524 2W8N A G409D Disease Disease 0.975 2W8N A V487E Disease Disease 0.963 2W8N A G533R Disease Disease 0.967 2W8N A C93F Disease Disease 0.964 2WBJ F G135S Neutral Neutral 0.152 2WBJ F S135G *Neutral Neutral 0.000 2WBJ F A140T Neutral Neutral 0.039 2WBJ F T140A *Neutral Neutral 0.001 2WBJ F F26Y Neutral Neutral 0.133 2WBJ F Y26F *Neutral Neutral 0.017 2WBJ F H30Y *Neutral Neutral 0.002 2WBJ F Y30H Neutral Neutral 0.169 2WBJ F F67I *Neutral Neutral 0.009 2WBJ F I67F Neutral Neutral 0.036 2WBJ F N77T *Neutral Neutral 0.001 2WBJ F T77N Neutral Neutral 0.394 2WBJ F G86V *Neutral Neutral 0.045 2WBJ F V86G Neutral Neutral 0.009 2WEM A A146T Neutral Neutral 0.442 2WEM A T146A *Neutral Neutral 0.000 2WK6 A G145R Disease Disease 0.973 2WK6 A G153S Disease Disease 0.963 2WK6 A K222R Disease Disease 0.809 2WK6 A E289A Disease Disease 0.917 2WK6 A R44Q Disease Disease 0.899 2WK6 A L471S *Neutral Neutral 0.215 2WK6 A S471L Neutral Neutral 0.387 2WM3 A I23T *Neutral Neutral 0.122 2WM3 A T23I Neutral Neutral 0.283 2WM3 A L252P *Neutral Neutral 0.003 2WM3 A P252L Neutral Neutral 0.500 2WNS A V109G Disease Disease 0.857 2WNS A G30S *Neutral Neutral 0.001 2WNS A S30G Neutral Disease 0.839 2WNS A R96G Disease Disease 0.908 2YYN B R126S Neutral Neutral 0.421 2YYN B S126R *Neutral Neutral 0.029 2Z0W A L12R *Neutral Neutral 0.005 2Z0W A R12L Neutral Neutral 0.308 2Z17 A E24Q *Neutral Neutral 0.001 2Z17 A Q24E Neutral Neutral 0.066 2Z5V A R49C Disease Disease 0.921 2Z5X A F314V Neutral Disease 0.777 2Z5X A V314F *Neutral Neutral 0.001 2Z5X A K520R Neutral Neutral 0.243 2Z5X A R520K *Neutral Neutral 0.003 2Z6O A C90Y *Neutral Neutral 0.000 2Z6O A Y90C Neutral Disease 0.875 2Z7F E V164F Disease Neutral 0.270 2Z7F E G18V Disease Disease 0.566 2Z7F E R186Q Disease Neutral 0.108 2Z7F E I216V *Neutral Neutral 0.054 2Z7F E V216I Neutral Neutral 0.137 2Z7F E L82V *Neutral Neutral 0.007 2Z7F E V82L Neutral Neutral 0.059 2Z7F E L85V *Neutral Neutral 0.001 2Z7F E V85L Neutral Neutral 0.261 2ZCH P I114L *Neutral Neutral 0.012 2ZCH P L114I Neutral Neutral 0.106 2ZCH P I163T Neutral Disease 0.608 2ZCH P T163I *Neutral Neutral 0.076 2ZCH P E23K Neutral Neutral 0.043 2ZCH P K23E *Neutral Neutral 0.047 2ZFU A P329S Neutral Neutral 0.126 2ZFU A S329P *Neutral Neutral 0.446 2ZGC A G196R Neutral Disease 0.916 2ZGC A R196G *Neutral Neutral 0.001 2ZHN A G5S Neutral Neutral 0.191 2ZHN A S5G *Neutral Neutral 0.001 2ZOC A M85T *Neutral Neutral 0.184 2ZOC A T85M Neutral Neutral 0.166 3B6R A K177R Neutral Neutral 0.137 3B6R A R177K *Neutral Neutral 0.118 3B6R A L309S *Neutral Neutral 0.052 3B6R A S309L Neutral Neutral 0.130 3B6R A F360L *Neutral Neutral 0.009 3B6R A L360F Neutral Disease 0.832 3B8K A D365N Neutral Disease 0.815 3B8K A N365D *Neutral Neutral 0.360 3BC7 A P213S Neutral Neutral 0.037 3BC7 A S213P *Neutral Neutral 0.202 3BC7 A A278V *Neutral Neutral 0.070 3BC7 A V278A Neutral Neutral 0.051 3BC7 A D288N *Neutral Neutral 0.002 3BC7 A N288D Neutral Neutral 0.243 3BC7 A A300P Neutral Neutral 0.412 3BC7 A P300A *Neutral Neutral 0.038 3BCH A R117W Neutral Neutral 0.349 3BCH A W117R *Neutral Neutral 0.011 3BH7 B C108G Disease Disease 0.961 3BH7 B R118C Disease Disease 0.986 3BH7 B R118H Disease Disease 0.976 3BH7 B R118L Disease Disease 0.976 3BH7 B E138G Disease Disease 0.928 3BH7 B K144R Neutral Neutral 0.161 3BH7 B R144K *Neutral Neutral 0.487 3BH7 B L188P Disease Disease 0.977 3BH7 B L253R Disease Disease 0.935 3BH7 B R282W Neutral Disease 0.830 3BH7 B W282R *Neutral Neutral 0.220 3BH7 B D338Y Neutral Disease 0.934 3BH7 B Y338D *Neutral Neutral 0.002 3BH7 B C67Y Disease Disease 0.951 3BH7 B C86Y Disease Disease 0.965 3BH7 B P95L Disease Disease 0.949 3BLJ B A499T Neutral Neutral 0.134 3BLJ B T499A *Neutral Neutral 0.129 3BLJ B G606R Neutral Disease 0.929 3BLJ B R606G *Neutral Neutral 0.001 3BO8 A G107W Neutral Disease 0.767 3BO8 A W107G *Neutral Neutral 0.001 3BO8 A F109L Neutral Neutral 0.005 3BO8 A L109F *Neutral Neutral 0.204 3BO8 A K127N *Neutral Neutral 0.002 3BO8 A N127K Neutral Disease 0.670 3BO8 A I142T Neutral Neutral 0.419 3BO8 A T142I *Neutral Neutral 0.001 3BO8 A H145R *Neutral Neutral 0.001 3BO8 A R145H Neutral Neutral 0.334 3BO8 A L156R *Neutral Neutral 0.061 3BO8 A R156L Neutral Neutral 0.307 3BO8 A A158V *Neutral Neutral 0.330 3BO8 A V158A Neutral Neutral 0.003 3BO8 A R17S Neutral Neutral 0.313 3BO8 A S17R *Neutral Neutral 0.008 3BO8 A H181R *Neutral Neutral 0.000 3BO8 A R181H Neutral Neutral 0.484 3BO8 A G56R Neutral Neutral 0.500 3BO8 A R56G *Neutral Neutral 0.001 3BO8 A G65R *Neutral Neutral 0.007 3BO8 A R65G Neutral Neutral 0.228 3BO8 A M67V Neutral Neutral 0.097 3BO8 A V67M *Neutral Neutral 0.064 3BO8 A A76E Neutral Neutral 0.178 3BO8 A E76A *Neutral Neutral 0.031 3BO8 A F9S Neutral Neutral 0.180 3BO8 A S9F *Neutral Neutral 0.243 3BO8 A A90D *Neutral Neutral 0.141 3BO8 A D90A Neutral Neutral 0.003 3BO8 A I97M Neutral Neutral 0.126 3BO8 A M97I *Neutral Neutral 0.290 3BRV C A710T Neutral Disease 0.845 3BRV C T710A *Neutral Neutral 0.001 3BRV C F734L Neutral Disease 0.532 3BRV C L734F *Neutral Neutral 0.003 3BRV C A736T Neutral Neutral 0.315 3BRV C T736A *Neutral Neutral 0.004 3BRV D E57K Disease Disease 0.908 3BUV A L106F Disease Disease 0.757 3BUV A P133R Disease Disease 0.663 3BUV A P198L Disease Disease 0.760 3BUV A R261C Disease Disease 0.878 3BWM A M108V *Neutral Neutral 0.155 3BWM A V108M Neutral Neutral 0.458 3BWM A A22S Neutral Disease 0.705 3BWM A S22A *Neutral Neutral 0.378 3BWM A A52T Neutral Neutral 0.215 3BWM A T52A *Neutral Neutral 0.041 3BWM A A96V Neutral Disease 0.842 3BWM A V96A *Neutral Neutral 0.001 3BX6 A C149R *Neutral Neutral 0.259 3BX6 A R149C Neutral Disease 0.591 3BX6 A M156V *Neutral Neutral 0.085 3BX6 A V156M Neutral Neutral 0.039 3BX6 A Q20R Neutral Neutral 0.040 3BX6 A R20Q *Neutral Neutral 0.017 3BYH A R183W Disease Disease 0.906 3BYH A L243P *Neutral Neutral 0.000 3BYH A P243L Neutral Disease 0.763 3BZE A G107R *Neutral Neutral 0.390 3BZE A R107G Neutral Neutral 0.001 3BZE A G157R *Neutral Neutral 0.003 3BZE A R157G Neutral Neutral 0.380 3BZE A K77N *Neutral Neutral 0.002 3BZE A N77K Neutral Neutral 0.271 3BZE A G83R Neutral Neutral 0.051 3BZE A R83G *Neutral Neutral 0.002 3C0I A R28L Disease Neutral 0.343 3C3R A A309T Neutral Neutral 0.061 3C3R A T309A *Neutral Neutral 0.031 3C3U A H170R *Neutral Neutral 0.089 3C3U A R170H Neutral Neutral 0.090 3C3U A L172Q *Neutral Neutral 0.056 3C3U A Q172L Neutral Neutral 0.447 3C5T A Q131R *Neutral Neutral 0.001 3C5T A R131Q Neutral Neutral 0.105 3C5T A H44R *Neutral Neutral 0.004 3C5T A R44H Neutral Neutral 0.127 3C7X A I355M *Neutral Neutral 0.062 3C7X A M355I Neutral Neutral 0.390 3C7X A H431R *Neutral Neutral 0.153 3C7X A R431H Neutral Neutral 0.474 3CAF A A172F Disease Disease 0.611 3CAF A M186T Neutral Neutral 0.016 3CAF A T186M *Neutral Neutral 0.172 3CFW A F155L Neutral Neutral 0.248 3CFW A L155F *Neutral Neutral 0.020 3CL3 D L227P Disease Disease 0.955 3CMQ A C21S *Neutral Neutral 0.047 3CMQ A S21C Neutral Disease 0.674 3CMQ A N244S Neutral Neutral 0.135 3CMQ A S244N *Neutral Neutral 0.487 3COG D I67T *Neutral Neutral 0.002 3COG D T67I Neutral Disease 0.827 3CUQ C I76V Neutral Neutral 0.054 3CUQ C V76I *Neutral Neutral 0.097 3CZV A N67S Neutral Neutral 0.239 3CZV A S67N *Neutral Neutral 0.285 3D25 A G107W *Neutral Disease 0.726 3D25 A W107G Neutral Neutral 0.001 3D25 A K138M *Neutral Neutral 0.025 3D25 A M138K Neutral Neutral 0.206 3D25 A A149T Neutral Neutral 0.271 3D25 A T149A *Neutral Neutral 0.002 3D25 A E152V *Neutral Neutral 0.060 3D25 A V152E Neutral Neutral 0.175 3D25 A L156Q Neutral Neutral 0.151 3D25 A L156W Neutral Neutral 0.147 3D25 A Q156L *Neutral Neutral 0.199 3D25 A W156L *Neutral Neutral 0.182 3D25 A E163T *Neutral Neutral 0.077 3D25 A T163E Neutral Neutral 0.057 3D25 A D166E *Neutral Neutral 0.002 3D25 A E166D Neutral Neutral 0.339 3D25 A G167W *Neutral Neutral 0.002 3D25 A W167G Neutral Neutral 0.449 3D25 A A236E Neutral Disease 0.669 3D25 A E236A *Neutral Neutral 0.005 3D25 A D30N Neutral Neutral 0.487 3D25 A N30D *Neutral Neutral 0.001 3D25 A A41G Neutral Neutral 0.068 3D25 A G41A *Neutral Neutral 0.005 3D25 A Q43R Neutral Neutral 0.127 3D25 A R43Q *Neutral Neutral 0.139 3D25 A K66N Neutral Neutral 0.072 3D25 A N66K *Neutral Neutral 0.221 3D25 A H70Q Neutral Neutral 0.104 3D25 A Q70H *Neutral Neutral 0.045 3D25 A I73T *Neutral Neutral 0.011 3D25 A T73I Neutral Neutral 0.125 3D25 A D74H *Neutral Neutral 0.351 3D25 A H74D Neutral Neutral 0.290 3D25 A F9Y Neutral Neutral 0.011 3D25 A Y9F *Neutral Neutral 0.500 3D25 A L95V *Neutral Neutral 0.369 3D25 A V95L Neutral Neutral 0.040 3D25 A M97R *Neutral Neutral 0.031 3D25 A R97M Neutral Neutral 0.318 3D25 A C99Y *Neutral Neutral 0.004 3D25 A F99Y *Neutral Neutral 0.004 3D25 A Y99C Neutral Disease 0.725 3D25 A Y99F Neutral Neutral 0.488 3D59 B K191N Neutral Neutral 0.128 3D59 B N191K *Neutral Neutral 0.011 3D59 B I198T Neutral Neutral 0.047 3D59 B T198I *Neutral Neutral 0.009 3D59 B V279F Disease Disease 0.707 3D59 B Q281R Disease Disease 0.590 3D59 B A379V *Neutral Neutral 0.005 3D59 B V379A Neutral Neutral 0.304 3D59 B H92R *Neutral Neutral 0.035 3D59 B R92H Neutral Neutral 0.158 3DK9 A C109R *Neutral Neutral 0.015 3DK9 A R109C Neutral Disease 0.788 3DK9 A G188R Neutral Neutral 0.250 3DK9 A G188S Neutral Neutral 0.337 3DK9 A R188G *Neutral Neutral 0.181 3DK9 A S188G *Neutral Neutral 0.060 3DK9 A I217V Neutral Neutral 0.189 3DK9 A V217I *Neutral Neutral 0.214 3DK9 A D253E *Neutral Neutral 0.078 3DK9 A E253D Neutral Neutral 0.274 3DK9 A H270P *Neutral Neutral 0.180 3DK9 A P270H Neutral Neutral 0.192 3DLS A M1210V *Neutral Neutral 0.080 3DLS A V1210M Neutral Neutral 0.178 3DLS A C1266F *Neutral Neutral 0.025 3DLS A F1266C Neutral Disease 0.601 3DOF B E87K Neutral Neutral 0.356 3DOF B K87E *Neutral Neutral 0.019 3DWY A Y1175C Disease Disease 0.914 3DY0 A A102P *Neutral Neutral 0.193 3DY0 A P102A Neutral Neutral 0.041 3DY0 A G198R Neutral Disease 0.629 3DY0 A R198G *Neutral Neutral 0.472 3DY0 A A36V Neutral Neutral 0.395 3DY0 A V36A *Neutral Neutral 0.416 3DY0 A N45S Neutral Neutral 0.197 3DY0 A S45N *Neutral Neutral 0.170 3DY0 A G75V Neutral Disease 0.698 3DY0 A V75G *Neutral Disease 0.512 3DY0 A E86K *Neutral Neutral 0.150 3DY0 A K86E Neutral Neutral 0.013 3DY0 A L96P Neutral Neutral 0.267 3DY0 A P96L *Neutral Neutral 0.169 3E1U A H256R *Neutral Neutral 0.022 3E1U A R256H Neutral Disease 0.601 3E1U A E275Q *Neutral Neutral 0.034 3E1U A Q275E Neutral Neutral 0.414 3E3B X A188E *Neutral Neutral 0.056 3E3B X E188A Neutral Neutral 0.136 3E7G C R221W Neutral Disease 0.680 3E7G C W221R *Neutral Neutral 0.143 3EDY A Q100R Neutral Neutral 0.065 3EDY A R100Q *Neutral Neutral 0.243 3EDY A R127Q Disease Neutral 0.278 3EDY A S153P Disease Disease 0.885 3EDY A H175R *Neutral Neutral 0.037 3EDY A R175H Neutral Disease 0.695 3EDY A C185R *Neutral Neutral 0.029 3EDY A R185C Neutral Disease 0.810 3EDY A R206C Disease Disease 0.876 3EDY A R206H Disease Disease 0.795 3EDY A V277M Disease Disease 0.586 3EDY A Q278P Disease Disease 0.935 3EDY A G284V Disease Disease 0.601 3EDY A N286S Disease Disease 0.570 3EDY A I287N Disease Disease 0.654 3EDY A E343K Disease Disease 0.763 3EDY A T353P Disease Disease 0.903 3EDY A C365R Disease Disease 0.800 3EDY A C365Y Disease Disease 0.800 3EDY A V385D Disease Disease 0.889 3EDY A G389E Disease Disease 0.933 3EDY A Q422H Disease Disease 0.927 3EDY A K428N Disease Neutral 0.126 3EDY A R447H Disease Disease 0.939 3EDY A A454E Disease Disease 0.931 3EDY A G473R Disease Disease 0.831 3EDY A S475L Disease Disease 0.766 3EDY A F481C Disease Disease 0.898 3EDY A G482R Disease Disease 0.738 3EDY A L62S *Neutral Neutral 0.309 3EDY A S62L Neutral Disease 0.561 3EDY A G77R Disease Disease 0.785 3EI4 B M215T Neutral Disease 0.605 3EI4 B T215M *Neutral Neutral 0.042 3EI4 B K244E Disease Disease 0.789 3EI4 B R273H Disease Disease 0.911 3EI4 B A293T Neutral Disease 0.790 3EI4 B T293A *Neutral Neutral 0.024 3ELO A A-6D *Neutral Neutral 0.001 3ELO A D-6A Neutral Neutral 0.226 3ELO A K67N *Neutral Neutral 0.007 3ELO A N67K Neutral Neutral 0.247 3ELO A N67T Neutral Neutral 0.158 3ELO A T67N *Neutral Neutral 0.007 3EQM A M201T *Neutral Neutral 0.050 3EQM A T201M Neutral Neutral 0.064 3EQM A C264R *Neutral Neutral 0.009 3EQM A R264C Neutral Neutral 0.470 3EQM A R365Q Disease Disease 0.637 3EQM A L375R *Neutral Neutral 0.000 3EQM A R375C Disease Disease 0.812 3EQM A R375L Neutral Disease 0.785 3EQM A R435C Disease Disease 0.826 3EQM A C437Y Disease Disease 0.723 3EVS B E110K Disease Neutral 0.301 3EVS B C19Y Disease Disease 0.922 3EVS B P55T Disease Disease 0.591 3EVS B R57L Disease Neutral 0.446 3EVS B S58T Disease Neutral 0.112 3EVS B H59L Disease Neutral 0.413 3EVS B L60P Disease Disease 0.893 3EVS B S94N Disease Disease 0.646 3EX0 B G429R Disease Disease 0.935 3EX0 B I446V Neutral Neutral 0.305 3EX0 B V446I *Neutral Neutral 0.028 3EXE B L1V Neutral Neutral 0.002 3EXE B V1L *Neutral Neutral 0.208 3EXE B Y102C Disease Disease 0.870 3EXE B P314S Disease Disease 0.941 3EXE E G133R Disease Disease 0.964 3EXE E V138M Disease Disease 0.865 3EXE E A170T Disease Neutral 0.404 3EXE E F176L Disease Disease 0.701 3EXE E M181V Disease Disease 0.837 3EXE E P188L Disease Disease 0.973 3EXE E T202A Disease Disease 0.868 3EXE E Y214N Disease Disease 0.855 3EXE E D229A Disease Disease 0.949 3EXE E R234G Disease Disease 0.945 3EXE E R234Q Disease Disease 0.950 3EXE E L253M *Neutral Disease 0.811 3EXE E M253L Neutral Neutral 0.438 3EXE E R259H Disease Disease 0.945 3EXE E H263L Disease Disease 0.950 3EXE E R273C Disease Disease 0.975 3EXE E R273H Disease Disease 0.949 3EXE E D286N Disease Disease 0.865 3EXE E D304E *Neutral Neutral 0.025 3EXE E E304D Neutral Neutral 0.114 3EXE E R349H Disease Disease 0.867 3EXE E R43C Disease Disease 0.966 3EXE E H84D Disease Disease 0.831 3F1R A G116R Neutral Disease 0.714 3F1R A R116G *Neutral Neutral 0.011 3F1R A A175P *Neutral Neutral 0.033 3F1R A P175A Neutral Neutral 0.287 3F1R A D206N Neutral Disease 0.767 3F1R A N206D *Neutral Neutral 0.000 3F1S A G118R Neutral Neutral 0.209 3F1S A R118G *Neutral Neutral 0.035 3F1S A L137Q Neutral Neutral 0.277 3F1S A Q137L *Neutral Neutral 0.031 3F1S A S140T *Neutral Neutral 0.094 3F1S A T140S Neutral Neutral 0.041 3F1S A H175R *Neutral Neutral 0.050 3F1S A R175H Neutral Neutral 0.208 3F1S A G250S Neutral Neutral 0.319 3F1S A S250G *Neutral Neutral 0.292 3F1S A P363Q *Neutral Neutral 0.170 3F1S A Q363P Neutral Disease 0.771 3F1S A Q363R Neutral Disease 0.632 3F1S A R363Q *Neutral Neutral 0.256 3F1S A G40S *Neutral Neutral 0.001 3F1S A S40G Neutral Neutral 0.147 3F2N A M706V Neutral Neutral 0.092 3F2N A V706M *Neutral Neutral 0.030 3F7Q A H1216Q Neutral Neutral 0.073 3F7Q A Q1216H *Neutral Neutral 0.036 3F7Q A R1225H Disease Neutral 0.158 3F7Q A R1281W Disease Disease 0.506 3FDW A I420V *Neutral Neutral 0.182 3FDW A V420I Neutral Neutral 0.275 3FHT A L149V *Neutral Neutral 0.095 3FHT A V149L Neutral Neutral 0.313 3FLG A S66P Disease Disease 0.955 3FUN A H130Y *Neutral Neutral 0.008 3FUN A Y130H Neutral Neutral 0.347 3FVH A H463L *Neutral Neutral 0.134 3FVH A L463H Neutral Neutral 0.403 3FVH A H518R *Neutral Neutral 0.011 3FVH A R518H Neutral Neutral 0.406 3FVH A L595S *Neutral Neutral 0.002 3FVH A S595L Neutral Disease 0.508 3FVH A H599R *Neutral Neutral 0.000 3FVH A R599H Neutral Neutral 0.451 3FX0 B A1288G Disease Disease 0.630 3FX0 B D1311N Disease Disease 0.873 3FX0 B E1315A Disease Disease 0.858 3FX0 B R1319Q Disease Disease 0.812 3FX0 B A1323P Disease Disease 0.765 3FXI A A175T *Neutral Neutral 0.006 3FXI A T175A Neutral Neutral 0.022 3FXI A Q188R Neutral Neutral 0.032 3FXI A R188Q *Neutral Neutral 0.020 3FXI A C246S Neutral Neutral 0.061 3FXI A S246C *Neutral Neutral 0.056 3FXI A D299G Neutral Neutral 0.083 3FXI A G299D *Neutral Neutral 0.028 3FXI A C306W Neutral Neutral 0.119 3FXI A W306C *Neutral Neutral 0.018 3FXI A G310V *Neutral Neutral 0.035 3FXI A V310G Neutral Neutral 0.199 3FXI A N329S Neutral Neutral 0.075 3FXI A S329N *Neutral Neutral 0.002 3FXI A F342Y Neutral Neutral 0.177 3FXI A Y342F *Neutral Neutral 0.021 3FXI A F385L *Neutral Neutral 0.010 3FXI A L385F Neutral Neutral 0.281 3FXI A I399T *Neutral Neutral 0.009 3FXI A T399I Neutral Neutral 0.043 3FXI A N400S *Neutral Neutral 0.012 3FXI A S400N Neutral Neutral 0.008 3FXI A F443L Neutral Neutral 0.249 3FXI A L443F *Neutral Neutral 0.001 3FXI A E474K Neutral Neutral 0.068 3FXI A K474E *Neutral Neutral 0.017 3FXI A H510Q *Neutral Neutral 0.013 3FXI A Q510H Neutral Neutral 0.024 3FZH A D32Y Neutral Neutral 0.452 3FZH A Y32D *Neutral Neutral 0.028 3G04 C R109Q Disease Neutral 0.029 3G04 C P162A Disease Neutral 0.196 3G04 C I167N Disease Disease 0.819 3G04 C K183R Disease Neutral 0.043 3G04 C F197I Disease Disease 0.838 3G04 C D219E Disease Neutral 0.217 3G04 C L252P Disease Disease 0.778 3G04 C E34K Neutral Neutral 0.500 3G04 C K34E *Neutral Neutral 0.011 3G04 C C41S Disease Disease 0.799 3G04 C P52T Neutral Neutral 0.038 3G04 C T52P *Neutral Neutral 0.064 3G33 A H127R *Neutral Neutral 0.110 3G33 A R127H Neutral Neutral 0.206 3G33 A R29C Disease Disease 0.795 3G33 A R29H Disease Disease 0.623 3G33 A N46S Disease Neutral 0.311 3G33 A Q87R *Neutral Neutral 0.010 3G33 A R87Q Neutral Neutral 0.127 3G65 B S104T *Neutral Neutral 0.010 3G65 B T104S Neutral Neutral 0.040 3G65 B D114G *Neutral Neutral 0.001 3G65 B G114D Neutral Disease 0.568 3G65 B A33G Neutral Disease 0.578 3G65 B G33A *Neutral Neutral 0.006 3G65 B H39Q Neutral Neutral 0.354 3G65 B Q39H *Neutral Neutral 0.012 3G6J A L292P *Neutral Neutral 0.031 3G6J A P292L Neutral Neutral 0.134 3G6J A D447E *Neutral Neutral 0.058 3G6J A E447D Neutral Neutral 0.087 3G6J A D527N Disease Disease 0.706 3G6J A G80R *Neutral Neutral 0.031 3G6J A R80G Neutral Neutral 0.088 3GDH A C754F *Neutral Neutral 0.050 3GDH A F754C Neutral Neutral 0.185 3GGR A A100S *Neutral Neutral 0.019 3GGR A S100A Neutral Neutral 0.450 3GGR A H239R Neutral Disease 0.600 3GGR A R239H *Neutral Neutral 0.034 3GGR A C3F Neutral Disease 0.796 3GGR A F3C *Neutral Neutral 0.004 3GGR A L71Q Neutral Disease 0.566 3GGR A Q71L *Neutral Neutral 0.016 3GGR B G126S *Neutral Neutral 0.002 3GGR B S126G Neutral Neutral 0.319 3GGR B K147Q *Neutral Neutral 0.070 3GGR B Q147K Neutral Neutral 0.223 3GGR B D221E Neutral Neutral 0.323 3GGR B E221D *Neutral Neutral 0.017 3GHG B H140N *Neutral Neutral 0.020 3GHG B N140H Neutral Neutral 0.165 3GHG B P70S Neutral Neutral 0.177 3GHG B S70P *Neutral Neutral 0.014 3GHG I E51G Neutral Neutral 0.257 3GHG I G51E *Neutral Neutral 0.006 3GHG J S47T Neutral Disease 0.725 3GHG J T47S *Neutral Neutral 0.000 3GJ3 A I95R *Neutral Neutral 0.005 3GJ3 A R95I Neutral Neutral 0.437 3GLR A I208V *Neutral Disease 0.592 3GLR A V208I Neutral Neutral 0.427 3GLR A G369S Neutral Disease 0.856 3GLR A S369G *Neutral Neutral 0.052 3GR4 A G204V Neutral Disease 0.938 3GR4 A V204G *Neutral Neutral 0.341 3GTU B I223V *Neutral Neutral 0.038 3GTU B V223I Neutral Neutral 0.033 3GXP B R100K Disease Disease 0.965 3GXP B R100T Disease Disease 0.943 3GXP B R112C Disease Disease 0.926 3GXP B R112H Disease Disease 0.865 3GXP B F113L Disease Disease 0.945 3GXP B F113S Disease Disease 0.955 3GXP B G128E Disease Disease 0.916 3GXP B L131P Disease Disease 0.954 3GXP B Y134S Disease Disease 0.927 3GXP B G138R Disease Disease 0.974 3GXP B C142R Disease Disease 0.944 3GXP B C142Y Disease Disease 0.947 3GXP B A143P Disease Disease 0.917 3GXP B A143T Disease Disease 0.798 3GXP B G144V Disease Disease 0.822 3GXP B P146S Disease Disease 0.875 3GXP B S148N Disease Disease 0.953 3GXP B S148R Disease Disease 0.944 3GXP B A156T Disease Disease 0.900 3GXP B A156V Disease Disease 0.878 3GXP B W162C Disease Disease 0.970 3GXP B W162R Disease Disease 0.955 3GXP B G163V Disease Disease 0.949 3GXP B D165V Disease Disease 0.934 3GXP B L166V Disease Disease 0.765 3GXP B D170V Disease Disease 0.959 3GXP B C172R Disease Disease 0.964 3GXP B C172Y Disease Disease 0.965 3GXP B G183D Disease Disease 0.855 3GXP B M187V Disease Disease 0.932 3GXP B C202W Disease Disease 0.964 3GXP B C202Y Disease Disease 0.973 3GXP B P205T Disease Disease 0.879 3GXP B N215S Disease Disease 0.575 3GXP B Y216D Disease Disease 0.889 3GXP B I219N Disease Disease 0.884 3GXP B C223G Disease Neutral 0.139 3GXP B N224D Disease Disease 0.948 3GXP B N224S Disease Disease 0.948 3GXP B W226R Disease Disease 0.959 3GXP B R227Q Disease Disease 0.956 3GXP B A230T Disease Neutral 0.423 3GXP B D231N Disease Disease 0.898 3GXP B S235C Disease Disease 0.750 3GXP B W236C Disease Disease 0.928 3GXP B W236L Disease Disease 0.895 3GXP B I242N Disease Disease 0.842 3GXP B D244H Disease Disease 0.664 3GXP B D244N Disease Neutral 0.195 3GXP B G258R Disease Disease 0.841 3GXP B P259L Disease Disease 0.914 3GXP B P259R Disease Disease 0.902 3GXP B G260A Disease Disease 0.949 3GXP B G261D Disease Disease 0.925 3GXP B N263S Disease Disease 0.903 3GXP B D264V Disease Disease 0.935 3GXP B P265R Disease Disease 0.855 3GXP B D266H Disease Disease 0.900 3GXP B D266N Disease Disease 0.925 3GXP B D266V Disease Disease 0.903 3GXP B M267I Disease Disease 0.932 3GXP B V269A Disease Disease 0.677 3GXP B N272K Disease Disease 0.917 3GXP B N272S Disease Disease 0.843 3GXP B Q279E Disease Neutral 0.014 3GXP B Q279H Disease Disease 0.842 3GXP B Q280H Disease Disease 0.631 3GXP B M284T Disease Disease 0.809 3GXP B W287C Disease Disease 0.944 3GXP B W287G Disease Disease 0.912 3GXP B A288D Disease Disease 0.942 3GXP B I289F Disease Disease 0.918 3GXP B M296I Disease Neutral 0.063 3GXP B M296V Disease Disease 0.795 3GXP B S297F Disease Disease 0.877 3GXP B N298H Disease Disease 0.726 3GXP B N298K Disease Disease 0.819 3GXP B N298S Disease Disease 0.664 3GXP B R301Q Disease Disease 0.880 3GXP B D313Y Disease Disease 0.635 3GXP B V316E Disease Disease 0.870 3GXP B L32P Disease Disease 0.973 3GXP B N320K Disease Disease 0.949 3GXP B N320Y Disease Disease 0.933 3GXP B Q321E Disease Disease 0.952 3GXP B Q327K Disease Disease 0.972 3GXP B G328A Disease Neutral 0.207 3GXP B G328R Disease Disease 0.896 3GXP B N34S Disease Disease 0.822 3GXP B W340R Disease Disease 0.929 3GXP B E341K Disease Disease 0.831 3GXP B R342Q Disease Disease 0.881 3GXP B G35R Disease Disease 0.878 3GXP B R356W Disease Disease 0.878 3GXP B E358K Disease Disease 0.624 3GXP B G361R Disease Neutral 0.467 3GXP B R363H Disease Disease 0.795 3GXP B G373D Disease Disease 0.895 3GXP B G373S Disease Disease 0.914 3GXP B A377D Disease Disease 0.691 3GXP B C378Y Disease Disease 0.833 3GXP B P40L Disease Disease 0.911 3GXP B P40S Disease Disease 0.918 3GXP B P409A Disease Disease 0.869 3GXP B P409T Disease Disease 0.892 3GXP B T410A Disease Disease 0.657 3GXP B M42V Disease Disease 0.953 3GXP B H46R Disease Disease 0.782 3GXP B H46Y Disease Disease 0.804 3GXP B W47G Disease Disease 0.934 3GXP B R49L Disease Disease 0.794 3GXP B R49P Disease Disease 0.906 3GXP B R49S Disease Disease 0.653 3GXP B C52R Disease Disease 0.929 3GXP B C52S Disease Disease 0.923 3GXP B C56F Disease Disease 0.876 3GXP B C56G Disease Disease 0.894 3GXP B C56Y Disease Disease 0.907 3GXP B E59K Disease Disease 0.661 3GXP B S65T Disease Disease 0.645 3GXP B E66Q Disease Disease 0.897 3GXP B M72V Disease Disease 0.695 3GXP B G85D Disease Disease 0.946 3GXP B Y86C Disease Disease 0.958 3GXP B L89P Disease Disease 0.934 3GXP B L89R Disease Disease 0.844 3GXP B I91T Disease Disease 0.885 3GXP B D92H Disease Disease 0.929 3GXP B D92Y Disease Disease 0.952 3GXP B D93G Disease Disease 0.928 3GXP B C94S Disease Disease 0.940 3GXP B C94Y Disease Disease 0.957 3GXP B W95S Disease Disease 0.943 3GXP B A97V Disease Disease 0.577 3HAJ A N176S Neutral Neutral 0.190 3HAJ A S176N *Neutral Neutral 0.004 3HAJ A I295M *Neutral Neutral 0.000 3HAJ A M295I Neutral Disease 0.809 3HBW A K197Q Neutral Neutral 0.299 3HBW A Q197K *Neutral Neutral 0.091 3HEI A K72N Neutral Disease 0.574 3HEI A N72K *Neutral Neutral 0.002 3HN9 A A501V Neutral Disease 0.656 3HN9 A V501A *Neutral Neutral 0.010 3HO5 H Q100H Disease Disease 0.838 3HO5 H A110D Disease Disease 0.903 3HO5 H I111F Disease Disease 0.759 3HO5 H I111N Disease Disease 0.802 3HO5 H N115K Disease Disease 0.898 3HO5 H W117G Disease Disease 0.922 3HO5 H W117R Disease Disease 0.931 3HO5 H H140P Disease Disease 0.984 3HO5 H H140Q Disease Disease 0.943 3HO5 H T150R Disease Disease 0.925 3HO5 H C183F Disease Disease 0.950 3HO5 H E188Q Disease Disease 0.734 3HO5 H D88V Disease Disease 0.877 3I2B A F100V Disease Disease 0.969 3I2B A T106M Disease Disease 0.889 3I2B A I114V Disease Disease 0.888 3I2B A D116G Disease Disease 0.761 3I2B A V124L Disease Neutral 0.140 3I2B A K129E Disease Neutral 0.228 3I2B A D136G Disease Neutral 0.375 3I2B A D136V Disease Disease 0.537 3I2B A R16C Disease Disease 0.979 3I2B A R25G Disease Disease 0.972 3I2B A R25Q Disease Disease 0.951 3I2B A L26F Disease Disease 0.962 3I2B A E35G Disease Disease 0.815 3I2B A N36K Disease Disease 0.960 3I2B A N47D Disease Disease 0.634 3I2B A N52S Disease Disease 0.910 3I2B A V56M Disease Disease 0.636 3I2B A T67M Disease Disease 0.842 3I2B A V70D Disease Disease 0.958 3I2B A P87L Disease Disease 0.741 3I2B A P87S Disease Disease 0.728 3I2B A D96N Disease Disease 0.873 3I2B A V97M Disease Disease 0.865 3I2B A Y99C Disease Disease 0.935 3II6 Y I658V Neutral Neutral 0.167 3II6 Y V658I *Neutral Neutral 0.085 3II6 Y A857T Neutral Disease 0.648 3II6 Y T857A *Neutral Neutral 0.109 4GTU A P1S *Neutral Neutral 0.002 4GTU A S1P Neutral Neutral 0.422 4GTU A A159V Neutral Neutral 0.245 4GTU A V159A *Neutral Neutral 0.031 4GTU A L207V Neutral Neutral 0.102 4GTU A V207L *Neutral Neutral 0.097 4GTU A F208Y *Neutral Neutral 0.256 4GTU A Y208F Neutral Neutral 0.076 4GTU A K210R *Neutral Disease 0.511 4GTU A R210K Neutral Neutral 0.006 4GTU A M211V *Neutral Neutral 0.407 4GTU A V211M Neutral Neutral 0.008 5PNT A Q105R Neutral Neutral 0.045 5PNT A R105Q *Neutral Neutral 0.037 5PNT A F136S *Neutral Neutral 0.026 5PNT A S136F Neutral Neutral 0.097 5PNT A K6N Neutral Disease 0.529 5PNT A N6K *Neutral Neutral 0.009 ____________________________________________________________ * Reverse mutations