SwissID SwissMut PDB Chain PDBMut Effect ___________________________________________________ P69892 H64L 1FDH G H63L Disease P06280 D234E 3GXP A D234E Disease P17066 A159V 3FE1 C A159V Neutral Q9UQ84 N279S 3QEB Z N279S Neutral P69892 H64Y 1FDH G H63Y Disease Q07889 G482R 1AWE A G82R Disease Q96E29 E396G 3M66 A E396G Neutral Q15465 G31R 3M1N A G31R Disease P06280 A135V 3GXP A A135V Disease Q04656 G853R 2KIJ A G48R Disease Q8WVQ1 P299L 1S1D A P229L Disease P04062 T408M 2WKL B T369M Disease P15056 L485F 3SKC B L485F Disease P60174 F278L 2JK2 A F240L Disease P09936 I93M 2ETL A I93M Disease P02042 Q126E 1SHR B Q125E Neutral P20036 M62L 3LQZ A M31L Neutral P21583 N36S 1EXZ B N211S Disease P68871 V21M 1IRD B V220M Neutral P52803 N55K 3MX0 B N55K Neutral O43602 K131N 2XRP I K50N Disease P01909 C70Q 1S9V A C44Q Neutral P01909 C70K 1S9V A C44K Neutral P48060 R211Q 3Q2U A R211Q Neutral P35475 A436P 1Y24 A A436P Disease O15553 P646L 2WL1 A P646L Disease P79483 L39Y 2Q6W B L10Y Neutral P04062 G232E 2WKL B G193E Disease P08709 G391C 2BZ6 H G184AC Disease Q9NWX6 L232P 3OTC A L203P Neutral P00558 R206P 2XE6 A R205P Disease P08709 G391S 2BZ6 H G184AS Disease Q9Y3A5 I212T 2L9N A I212T Disease Q12809 G53R 2L0W A G53R Disease O75822 A141T 3BPJ B A141T Neutral Q06520 A261T 3F3Y A A261T Neutral Q14203 G71R 1TXQ A G71R Disease P00451 G2198V 3HNY M G2179V Disease P06280 I219T 3GXP A I219T Disease Q14203 G71E 1TXQ A G71E Disease P00451 Q2330P 3HNY M Q2311P Disease Q06124 Q79R 3TKZ A Q79R Disease P04062 G234W 2WKL B G195W Disease Q06124 Q79P 3TKZ A Q79P Disease P04062 G234E 2WKL B G195E Disease P23921 K590Q 3HND A K590Q Neutral O95243 D568H 3IHO A D568H Neutral P00740 R384L 3LC3 A R170L Disease P19878 R184P 1E96 B R184P Disease P05108 A359V 3N9Y A A320V Disease P04062 M92T 2WKL B M53T Neutral P49768 E318G 2KR6 A E318G Neutral P06280 D93N 3GXP A D93N Disease P06132 G168R 1R3Q A G168R Disease P00742 V338M 3KL6 A V118M Disease P43632 S103C 3H8N A S82C Neutral P04062 E388K 2WKL B E349K Disease P35555 D2166N 1EMN A D2166N Disease P79483 T80R 2Q6W B T51R Neutral P49768 A431E 2KR6 A A431E Disease P69891 D44N 1I3D A D43N Neutral P20933 G302R 1APY B G279R Disease P00740 C178R 2WPH E C132R Disease P00740 C178W 2WPH E C132W Disease P00740 R191C 2WPH E R145C Disease Q6FI81 A34E 2LD4 A A34E Neutral P00740 R191H 2WPH E R145H Disease P04062 W432R 2WKL B W393R Disease P49768 A426P 2KR6 A A426P Disease P21728 S259Y 1OZ5 A S259Y Neutral P43632 K65M 3H8N A K44M Neutral Q02127 R199C 2FPV A R200C Disease P08709 F388S 2BZ6 H F181S Disease P04439 E176V 2XPG A E152V Neutral P08174 A227P 1H03 P A71P Neutral P00740 I136T 2WPH E I90T Disease P00451 M2257V 3HNY M M2238V Disease P53634 Y412C 2DJF C Y388C Disease O43602 R140L 2XRP I R59L Disease O43602 R140H 2XRP I R59H Disease P08709 C121F 2FLB L C61F Disease P69891 P37R 1I3D A P36R Neutral P02545 I469T 1IVT A I469T Disease P15735 V106E 2Y7J A V106E Disease P48436 M113T 1SX9 A M13T Disease P48436 M113V 1SX9 A M13V Disease Q9BZS1 R397W 3QRF F R397W Disease P35475 G84R 1Y24 A G84R Disease P04062 R502P 2WKL B R463P Disease P04062 Y451H 2WKL B Y412H Disease Q8WZ42 L34315P 2WP3 T L64P Disease P36897 G52R 1TBI A G19R Disease P15056 I463S 3SKC B I463S Disease Q14623 V190A 3K7G B V190A Disease P04062 F76V 2WKL B F37V Disease P68871 L15R 1IRD B L214R Neutral P07359 A254S 1GWB A A254S Neutral Q15465 C183R 3MXW A C183R Disease Q15465 C183Y 3MXW A C183Y Disease Q92838 G381R 1RJ7 A G381R Disease P63316 A8V 1AP4 A A8V Disease P36897 C41Y 1TBI A C8Y Disease Q30154 A87E 1FV1 B A58E Neutral P26998 V159I 3QK3 B V159I Neutral O75326 R207Q 3NVQ A R207Q Neutral O15553 P705S 2WL1 A P705S Disease Q92876 R78W 1LO6 A R74W Neutral P68871 E7Q 1IRD B E206Q Neutral P30460 S48A 1AGD A S24A Neutral P15924 N287K 3R6N A N287K Disease P01130 V429M 1LRX B V429M Disease P30460 S48T 1AGD A S24T Neutral P45877 H160L 2ESL A H160L Neutral P30460 S48P 1AGD A S24P Neutral P00451 D2286G 3HNY M D2267G Disease O14936 Y268H 3C0I A Y268H Disease Q8WXF7 R239C 3Q5E A R239C Disease Q92769 R230C 3MAX B R234C Neutral P35475 H449N 1Y24 A H449N Neutral P69891 Q40R 1I3D A Q39R Neutral P53634 V129E 2DJF A V105E Disease Q12809 H70R 2L0W A H70R Disease P05107 R593C 3K6S B R571C Disease P04062 Y402C 2WKL B Y363C Disease O43602 I185T 2XRP I I104T Disease P08709 E325K 2BZ6 H E125K Disease O15194 N127S 2HHL A N49S Neutral P68871 N20D 1IRD B N219D Neutral P20702 I564V 3K6S A I545V Neutral O75326 R460H 3NVQ A R460H Neutral P00742 E350K 3KL6 A E129K Disease P68871 N20S 1IRD B N219S Neutral P04001 W177R 1KPW A W177R Disease Q8WXF7 A161P 3Q5E A A161P Disease P00451 E2200D 3HNY M E2181D Disease Q16772 R113Q 2VCV A R113Q Neutral P79483 F66S 2Q6W B F37S Neutral P06276 T278P 3O9M A T250P Disease P79483 F66Y 2Q6W B F37Y Neutral P08709 D403H 2BZ6 H D194H Disease P00451 C2193G 3HNY M C2174G Disease P79483 F66N 2Q6W B F37N Neutral P79483 F66L 2Q6W B F37L Neutral P05413 K53R 1HMR A K52R Neutral P04062 R87Q 2WKL B R48Q Disease P08709 P189S 2BZ6 L P129S Disease Q13426 I134T 3SR2 A I134T Neutral P01009 L65P 1QLP A L41P Neutral P04062 R87W 2WKL B R48W Disease P06280 L120V 3GXP A L120V Disease P05534 G89R 3NFN A G65R Neutral Q14623 P46L 3K7G B P46L Disease P13686 N262H 2BQ8 X N241H Disease P19878 D93E 1E96 B D93E Disease Q8WXF7 R217Q 3Q5E A R217Q Disease Q8NBP7 G106R 2QTW A G106R Neutral P00740 G139D 2WPH E G93D Disease P19544 C388R 1LU6 A C387R Disease P02545 R541P 1IVT A R541P Disease P00740 G139S 2WPH E G93S Disease P21333 A39G 3HOP B A39G Disease P00451 V2251A 3HNY M V2232A Disease P00451 V2251E 3HNY M V2232E Disease O14773 P202L 3EDY A P202L Disease Q15465 D147N 3MXW A D147N Disease O43602 D143N 2XRP I D62N Disease P06276 N124Y 3O9M A N96Y Disease Q07820 M231L 3KJ2 A M231L Neutral P53634 I453V 2DJF C I429V Neutral P11473 G33D 1KB2 A G33D Disease Q04656 G876R 2KIJ A G71R Disease Q04656 G876E 2KIJ A G71E Disease Q15465 S184L 3MXW A S184L Disease P08246 V101M 2Z7F E V85M Neutral P79483 R40L 2Q6W B R11L Neutral P04062 W417G 2WKL B W378G Disease Q9Y3Q4 S672R 3OTF A S672R Disease P51659 Y217C 1ZBQ A Y217C Disease P79483 R40S 2Q6W B R11S Neutral P55072 R95G 3QQ8 A R95G Disease P06276 A227V 3O9M A A199V Disease P05106 R515Q 3IJE B R489Q Neutral P05108 L141W 3N9Y A L102W Disease O94856 T159M 3P3Y A T159M Neutral P00740 C155F 2WPH E C109F Disease P22681 R420Q 1FBV A R420Q Disease Q06124 T42A 3TKZ A T42A Disease P54132 E1213K 2KV2 A E4K Neutral P50225 N235T 1Z28 A N235T Neutral P00742 K448N 3KL6 A K224N Disease P55212 E35K 3P45 A E35K Neutral Q9NVQ4 A117T 2KW1 A A27T Neutral Q9Y4U1 H122R 3SC0 A H122R Disease Q71DI3 A128V 3AV1 A A127V Neutral P02042 L89V 1SHR B L88V Neutral P21860 P30L 3P11 A P11L Neutral P01909 R75H 1S9V A R49H Neutral P02042 D48V 1SHR B D47V Neutral P02545 E361K 1X8Y A E361K Disease P17066 L198F 3FE1 C L198F Neutral P02545 E358K 1X8Y A E358K Disease P01909 R75S 1S9V A R49S Neutral P01375 A94T 3L9J T A18T Neutral Q14191 L1074F 2AXL A L126F Neutral P69905 G16R 1IRD A G15R Neutral Q68J44 S137R 2Y96 A S137R Neutral P02042 V12G 1SHR B V11G Neutral P01130 D90Y 1LDR A D27Y Disease P79483 A87E 2Q6W B A58E Neutral P01009 I116N 1QLP A I92N Neutral Q07889 R497Q 1AWE A R97Q Disease P08686 G56R 2GEG C G56R Disease P05107 N351S 3K6S B N329S Disease Q07889 E424K 1AWE A E24K Disease Q04656 Q924R 2KIJ A Q119R Disease P00451 I2209N 3HNY M I2190N Disease O43602 L178R 2XRP I L97R Disease P01909 L91A 1S9V A L66A Neutral P31371 S99N 1IHK A S99N Disease P02042 L76V 1SHR B L75V Neutral Q92947 M263V 1SIQ A M219V Disease P01909 L91T 1S9V A L66T Neutral Q9UQ84 V27A 3QEB Z V27A Neutral P04062 Y343C 2WKL B Y304C Disease P05108 V415E 3N9Y A V376E Disease P17066 N170K 3FE1 C N170K Neutral P79483 L96I 2Q6W B L67I Neutral P08709 D183N 2BZ6 L D123N Disease Q14203 G71A 1TXQ A G71A Disease Q13224 S407N 1S11 A S407N Neutral P01909 R101C 1S9V A R76C Neutral P20036 A82T 3LQZ A A51T Neutral P06132 G170D 1R3Q A G170D Disease P32322 G206W 2IZZ E G206W Disease P05106 C601R 3IJE B C575R Disease P04062 S235P 2WKL B S196P Disease P01130 A431T 1LRX B A431T Disease P05534 H27Q 3NFN A H3Q Neutral Q14203 T72P 1TXQ A T72P Disease P04439 F133L 2XPG A F109L Neutral P04062 D448V 2WKL B D409V Disease P40259 G137S 3KG5 A G137S Disease P01909 P44L 1S9V A P18L Neutral P08603 I1169L 2G7I A I1169L Disease P04062 D448H 2WKL B D409H Disease Q06124 A72S 3TKZ A A72S Disease Q06124 A72V 3TKZ A A72V Disease Q06124 A72T 3TKZ A A72T Disease P04062 P426L 2WKL B P387L Disease O15553 I641F 2WL1 A I641F Disease Q06124 A72G 3TKZ A A72G Disease P08709 R139K 2FLB L R79K Disease P08709 S120P 2FLB L S60P Disease P21333 M102V 3HOP B M102V Disease P08709 M387T 2BZ6 H M180T Disease P08709 M387V 2BZ6 H M180V Disease P08709 R139Q 2FLB L R79Q Disease Q30154 R35C 1FV1 B R6C Neutral P08709 R139W 2FLB L R79W Disease Q06323 S55N 1AVO A S55N Neutral Q07889 Q477R 1AWE A Q77R Disease P00441 A96G 2C9V A A95G Disease P68871 E23A 1IRD B E222A Neutral Q07820 A227V 3KJ2 A A227V Neutral P04001 N94K 1KPW A N94K Disease Q06124 N58K 3TKZ A N58K Disease P04062 F252I 2WKL B F213I Disease P35555 C1577G 1UZJ A C1577G Disease P01909 C70R 1S9V A C44R Neutral P02647 R34L 3R2P A R10L Neutral P01909 S185I 1S9V A S160I Neutral P06280 M42L 3GXP A M42L Disease P08709 T241N 2BZ6 H T45N Disease P51681 R31H 1ND8 A R31H Neutral Q04656 G860V 2KIJ A G55V Disease P21333 A128V 3HOP B A128V Disease P17066 T297K 3FE1 C T297K Neutral P04062 R209C 2WKL B R170C Disease P13686 G109R 2BQ8 X G88R Disease P04062 R209P 2WKL B R170P Disease P00451 A2220P 3HNY M A2201P Disease P00734 E509A 1EB1 H E146A Disease P20933 T257I 1APY B T234I Disease P43026 R399C 3EVS B R18C Disease P01909 L74F 1S9V A L48F Neutral P43632 N178H 3H8N A N157H Neutral P04062 G416S 2WKL B G377S Disease P00742 G420R 3KL6 A G196R Disease Q9Y5Z4 E191A 3R8J A E191A Neutral P05534 L119V 3NFN A L95V Neutral P32754 V340L 3ISQ A V340L Neutral P06276 F446S 3O9M A F418S Disease O43570 E143K 1JD0 A E117K Disease Q06124 D61G 3TKZ A D61G Disease P08709 T384M 2BZ6 H T177M Disease P04062 L483P 2WKL B L444P Disease P79483 V86A 2Q6W B V57A Neutral P79483 V86D 2Q6W B V57D Neutral O00625 V228A 3ACL A V228A Neutral P69891 H3Q 1I3D A H2Q Neutral Q14203 Q74P 1TXQ A Q74P Disease Q12809 R100G 2L0W A R100G Disease P79483 V86S 2Q6W B V57S Neutral P60174 I208V 2JK2 A I170V Disease P26998 R105Q 3QK3 B R105Q Neutral P09874 A188T 3ODC A A188T Neutral P17066 E194K 3FE1 C E194K Neutral P20333 V187M 3ALQ R V165M Neutral Q9UG22 N152S 2XTM A N152S Neutral P68871 K18Q 1IRD B K217Q Neutral P19878 W137R 1E96 B W137R Disease P35555 N1489K 1UZJ A N1489K Disease P00734 G601V 1EB1 H G226V Disease P35475 P496R 1Y24 A P496R Disease P21333 A200S 3HOP B A200S Disease Q06124 G60A 3TKZ A G60A Disease Q06210 R514W 2ZJ3 A R495W Disease P68871 K18N 1IRD B K217N Neutral P00338 R315C 1I10 A R314C Neutral P06400 V654E 1GUX B V654E Disease P15924 S299R 3R6N A S299R Disease P51659 R106P 1ZBQ A R106P Disease P35968 V297I 3S37 X V297I Neutral P19544 H397P 1LU6 A H396P Disease P32322 R266Q 2IZZ E R266Q Disease Q9NW38 S144F 3ZQS A S144F Neutral P04062 A215D 2WKL B A176D Disease P19878 D108V 1E96 B D108V Disease Q06210 R403H 2ZJ3 A R384H Disease P05107 D300V 3K6S B D278V Disease P01909 L124V 1S9V A L99V Neutral P08686 L167P 2GEG C L167P Disease P27930 E181K 3O4O C E168K Neutral P04062 T530I 2WKL B T491I Disease P06280 D264Y 3GXP A D264Y Disease Q30154 T186I 1FV1 B T157I Neutral P04062 K118N 2WKL B K79N Disease O15553 I640M 2WL1 A I640M Disease P04062 P161L 2WKL B P122L Disease P08709 Q160R 2BZ6 L Q100R Disease Q07820 E173D 3KJ2 A E173D Neutral P35914 R165Q 2CW6 A R165Q Disease Q9Y4U1 R161G 3SC0 A R161G Disease Q68J44 D66N 2Y96 A D66N Neutral P05534 G131W 3NFN A G107W Neutral P01909 V68A 1S9V A V42A Neutral Q9Y4U1 R161Q 3SC0 A R161Q Disease P06280 L300F 3GXP A L300F Disease P10147 E78D 2X69 A E56D Neutral P08709 G138D 2FLB L G78D Disease P32322 R251H 2IZZ E R251H Disease P01909 S152A 1S9V A S127A Neutral P07738 R90C 2H4X A R90C Disease P04070 R211Q 1PCU A R169Q Neutral P04062 L363P 2WKL B L324P Disease P08603 W1183C 2G7I A W1183C Disease P01909 G63E 1S9V A G37E Neutral O95340 T48R 2AX4 A T58R Disease P04062 M455V 2WKL B M416V Disease P06280 S276G 3GXP A S276G Disease P06276 G143D 3O9M A G115D Disease P08709 A266T 2BZ6 H A66T Disease Q9BTZ2 A31T 3O4R A A31T Neutral P36897 P83L 1TBI A P50L Disease P05108 A189V 3N9Y A A150V Disease P15056 T599R 3SKC B T599R Disease P13686 K52M 2BQ8 X K31M Disease P00451 R2326G 3HNY M R2307G Disease P00451 R2326L 3HNY M R2307L Disease P00734 R461W 1EB1 H R101W Disease P00451 R2326Q 3HNY M R2307Q Disease P00451 R2326P 3HNY M R2307P Disease P15056 L597R 3SKC B L597R Disease Q12809 G47V 2L0W A G47V Disease P15056 L597V 3SKC B L597V Disease P00451 G2344S 3HNY M G2325S Disease P08709 C389G 2BZ6 H C182G Disease P00451 G2344D 3HNY M G2325D Disease P00451 G2344C 3HNY M G2325C Disease Q8NBP7 T77I 2QTW A T77I Neutral Q8WZ42 I34306N 2WP3 T I55N Disease P17066 P178A 3FE1 C P178A Neutral P04062 F436S 2WKL B F397S Disease P01130 N370T 1HJ7 A N349T Disease P11473 R80Q 1KB2 A R80Q Disease P05108 L222P 3N9Y A L183P Disease O15553 K695M 2WL1 A K695M Disease O15553 K695R 2WL1 A K695R Disease P04062 F456V 2WKL B F417V Disease P69891 K62E 1I3D A K61E Neutral Q8NBP7 S127R 2QTW A S127R Disease P04062 A175E 2WKL B A136E Disease P04062 V230G 2WKL B V191G Disease P04062 G304D 2WKL B G265D Disease P04062 N435T 2WKL B N396T Disease P21333 E254K 3HOP B E254K Disease P06132 R113T 1R3Q A R113T Neutral P05107 S138P 3K6S B S116P Disease P01130 G565V 1LRX B G565V Neutral Q9NRK6 D545N 2YL4 A D545N Neutral Q9Y285 Q341R 3L4G A Q341R Neutral P21333 Q170P 3HOP B Q170P Disease P08709 G414C 2BZ6 H G205C Disease P04439 I166T 2XPG A I142T Neutral Q07889 L490R 1AWE A L90R Disease P20036 T103I 3LQZ A T72I Neutral P00558 D164V 2XE6 A D163V Disease P02042 V21E 1SHR B V20E Neutral P20702 F971L 3K6S A F952L Neutral P06400 Q685P 1GUX B Q685P Disease P01009 D280V 1QLP A D256V Neutral Q01968 N591K 3QBT B N591K Disease P79483 D57E 2Q6W B D28E Neutral P00558 T352N 2XE6 A T351N Neutral P02042 G17R 1SHR B G16R Neutral P08686 L107R 2GEG C L107R Disease P79483 D57N 2Q6W B D28N Neutral P17066 R95Q 3FE1 C R95Q Neutral P02753 G93D 1JYD A G75D Disease P00558 E252A 2XE6 A E251A Disease P04062 P328L 2WKL B P289L Disease P08709 R337C 2BZ6 H R134C Disease Q15465 P26L 3M1N A P26L Disease P04062 A485P 2WKL B A446P Disease P13686 T89I 2BQ8 X T68I Disease P53634 W39S 2DJF A W15S Disease P00451 D2307A 3HNY M D2288A Disease P13686 G215R 2BQ8 X G194R Disease P04062 E365K 2WKL B E326K Disease P04062 R368H 2WKL B R329H Neutral P00558 V266M 2XE6 A V265M Disease P79483 G113R 2Q6W B G84R Neutral P04439 L180Q 2XPG A L156Q Neutral P69891 E6K 1I3D A E5K Neutral P15056 K499E 3SKC B K499E Disease Q30154 H57Q 1FV1 B H28Q Neutral P15056 K499N 3SKC B K499N Disease P08709 H301Q 2BZ6 H H101Q Disease P20036 M62Q 3LQZ A M31Q Neutral P35228 S608L 3HR4 A S608L Neutral P08709 G157V 2BZ6 L G97V Disease P04439 R205H 2XPG A R181H Neutral P01009 E366K 1QLP A E342K Neutral P02042 R105S 1SHR B R104S Neutral P20036 M62K 3LQZ A M31K Neutral P53634 G139R 2DJF A G115R Disease Q9BUT1 N70S 2AG5 C N70S Neutral P04062 L224F 2WKL B L185F Disease P02766 T139M 3M1O A T119M Neutral P01024 R863K 2A74 B R841K Neutral P04062 W351C 2WKL B W312C Disease P13686 M264K 2BQ8 X M243K Disease P21397 E188K 2Z5X A E188K Neutral P19878 R102P 1E96 B R102P Disease P04062 P454R 2WKL B P415R Disease P01909 A182S 1S9V A A157S Neutral P06132 P106L 1R3Q A P106L Neutral Q92743 V297M 3NZI A V297M Disease Q8NBP7 V114A 2QTW A V114A Neutral P69891 G26R 1I3D A G25R Neutral P20702 E547K 3K6S A E528K Neutral P21860 N385S 3P11 A N366S Neutral Q10589 V143F 3MQB A V143F Neutral P00734 M380T 1EB1 H M32T Disease Q92838 G299D 1RJ7 A G299D Disease P01130 D579N 1LRX B D579N Disease P69905 A6P 1IRD A A5P Neutral P21860 T204I 3P11 A T185I Neutral Q15465 R144P 3MXW A R144P Disease Q9Y3A5 R126T 2L9N A R126T Disease P02545 R336Q 1X8Y A R336Q Disease P20036 E59D 3LQZ A E28D Neutral Q04656 L873R 2KIJ A L68R Disease P00740 C134Y 2WPH E C88Y Disease P20933 C306R 1APY B C283R Disease Q15465 G143D 3MXW A G143D Disease P06276 G393R 3O9M A G365R Disease P55072 R191Q 3QC8 A R191Q Disease P04062 A348V 2WKL B A309V Disease P00742 S374P 3KL6 A S152P Disease Q06210 R530W 2ZJ3 A R511W Disease P69905 A6D 1IRD A A5D Neutral P06280 R112S 3GXP A R112S Disease P46063 V372I 2WWY A V372I Neutral Q30154 D66Y 1FV1 B D37Y Neutral P06276 P65S 3O9M A P37S Disease P08709 M358V 2BZ6 H M156V Disease P06276 T271M 3O9M A T243M Disease P08709 M358I 2BZ6 H M156I Disease P01909 T160I 1S9V A T135I Neutral P21333 R196W 3HOP B R196W Disease Q8NBP7 D129G 2QTW A D129G Disease P19878 M79V 1E96 B M79V Neutral P21333 R196G 3HOP B R196G Disease P35475 Y76C 1Y24 A Y76C Disease P68871 K9Q 1IRD B K208Q Neutral Q15465 E136K 3MXW A E136K Disease P01130 G549D 1LRX B G549D Neutral Q15465 A110T 3MXW A A110T Disease Q06124 T73I 3TKZ A T73I Disease P02545 R455P 1IVT A R455P Disease P00451 C2345S 3HNY M C2326S Disease P13929 G156D 2XSX A G156D Disease P35475 F188L 1Y24 A F188L Disease P00451 C2345Y 3HNY M C2326Y Disease P07602 C241S 1N69 A C47S Disease P04062 S403T 2WKL B S364T Disease P08246 P139L 2Z7F E P124L Neutral P02042 E44G 1SHR B E43G Neutral P04062 R502C 2WKL B R463C Disease Q9UPP1 F315S 2WWU A F279S Disease Q9BUL8 D102A 3AJM A D102A Neutral P02042 E44K 1SHR B E43K Neutral Q9NP99 K135T 1SMO B K135T Neutral P50225 V223M 1Z28 A V223M Neutral P01127 I88V 3MJG A I7V Neutral P02042 A28S 1SHR B A27S Neutral P01130 G546D 1LRX B G546D Neutral P06276 S226G 3O9M A S198G Disease P69891 A54D 1I3D A A53D Neutral P29401 I181V 3MOS A I181V Neutral P50225 E282K 1Z28 A E282K Neutral P13686 L201P 2BQ8 X L180P Disease Q8WXF7 D43E 3Q5E A D43E Neutral P06400 L657P 1GUX B L657P Disease P07320 W43R 1HK0 X W42R Disease P04062 D354H 2WKL B D315H Disease Q16832 E113K 2WUH A E113K Disease P35555 W1570C 1UZJ A W1570C Disease P02042 N13K 1SHR B N12K Neutral P79483 A212P 2Q6W B A183P Neutral P60174 V192M 2JK2 A V154M Disease P19878 A140D 1E96 B A140D Disease P38398 G1706E 1T15 A G1706E Disease P20036 L104A 3LQZ A L73A Neutral P05534 Q180L 3NFN A Q156L Neutral P00749 K231Q 3IG6 B K61Q Neutral A2RUC4 S50G 3AL5 B S50G Neutral P06276 L358I 3O9M A L330I Disease P05534 Q180W 3NFN A Q156W Neutral P69905 L3R 1IRD A L2R Neutral P35555 P1090S 1LMJ A P24S Disease Q9Y4U1 Q27R 3SC0 A Q27R Disease O15553 V726A 2WL1 A V726A Disease P79483 L96F 2Q6W B L67F Neutral P00451 P2224L 3HNY M P2205L Disease P32754 I335M 3ISQ A I335M Disease P13686 D241N 2BQ8 X D220N Disease Q13158 C105W 3EZQ B C105W Disease P04062 L483R 2WKL B L444R Disease P06400 D697E 1GUX B D697E Neutral P05107 G273R 3K6S B G251R Disease P35475 W306L 1Y24 A W306L Disease P38398 G1788V 1T15 A G1788V Disease Q8N4Q0 C323F 2X7H A C323F Neutral P02042 V99M 1SHR B V98M Neutral P00374 D153V 1KMV A D152V Disease Q92838 L266R 1RJ7 A L266R Disease Q16548 G82D 3MQP A G82D Neutral P69891 E7Q 1I3D A E6Q Neutral P68871 D22G 1IRD B D221G Neutral O15553 V704I 2WL1 A V704I Disease P69891 E7G 1I3D A E6G Neutral P68871 D22H 1IRD B D221H Neutral P04062 K196Q 2WKL B K157Q Disease Q92838 V323G 1RJ7 A V323G Disease P01130 C318F 1HJ7 A C297F Disease P08709 V422F 2BZ6 H V213F Disease P01130 C318R 1HJ7 A C297R Disease P79483 A169T 2Q6W B A140T Neutral P00742 G363S 3KL6 A G140S Disease P22888 V144F 1LUT A V144F Disease Q14623 E95K 3K7G B E95K Disease Q6FI81 Q52E 2LD4 A Q52E Neutral P04062 P305R 2WKL B P266R Disease P00451 G2304V 3HNY M G2285V Disease P04062 D438Y 2WKL B D399Y Disease P32322 A257T 2IZZ E A257T Disease Q15465 D83V 3MXW A D83V Disease P52209 A268S 2JKV A A268S Neutral P04062 D438N 2WKL B D399N Disease P21333 E82V 3HOP B E82V Disease Q06124 Y63C 3TKZ A Y63C Disease P02511 R120G 2WJ7 B R57G Disease P09874 F54L 3ODA A F54L Neutral Q14191 S1079L 2AXL A S131L Neutral P79483 R68S 2Q6W B R39S Neutral Q9BUP3 S197R 2BKA A S197R Neutral Q8NBP7 R93C 2QTW A R93C Neutral P48060 D163E 3Q2U A D163E Neutral P08709 R283W 2BZ6 H R83W Disease P08709 S250F 2BZ6 H S54F Disease P19878 G44R 1E96 B G44R Disease P20036 M54T 3LQZ A M23T Neutral P19878 G44C 1E96 B G44C Disease P35555 G1127S 1LMJ A G61S Neutral P07359 G249S 1GWB A G249S Disease P07359 G249V 1GWB A G249V Disease P38398 L1764P 1T15 A L1764P Disease P22681 Q367P 1FBV A Q367P Disease P02042 E27D 1SHR B E26D Neutral P08686 E320K 2GEG C E320K Disease O75326 R207W 3NVQ A R207W Neutral O96017 R117G 1GXC A R117G Neutral P02042 C94G 1SHR B C93G Neutral Q92838 L293P 1RJ7 A L293P Disease Q9Y4U1 G156D 3SC0 A G156D Disease P00451 V2242M 3HNY M V2223M Neutral P00742 C404R 3KL6 A C182R Disease Q05086 C44Y 2KR1 A C21Y Neutral P04062 S310N 2WKL B S271N Disease P04062 S310G 2WKL B S271G Neutral P22891 R295H 3H5C B R255H Neutral P22681 K382E 1FBV A K382E Disease Q16772 G36E 2VCV A G36E Neutral P02545 D461Y 1IVT A D461Y Disease P04062 P440L 2WKL B P401L Disease P00441 L68P 2C9V A L67P Disease Q86U86 R678C 3MB4 A R646C Neutral O75897 I68M 2GWH B I68M Neutral P01009 R247C 1QLP A R223C Neutral P06276 R414C 3O9M A R386C Disease P06132 G303V 1R3Q A G303V Neutral P15529 P231R 3O8E B P197R Disease P08709 K401E 2BZ6 H K192E Disease Q9NXS2 P214L 3PB6 X P214L Neutral P06276 P128S 3O9M A P100S Disease P20933 G252E 1APY B G229E Disease P11473 H35Q 1KB2 A H35Q Disease P21728 K81R 1OZ5 A K81R Neutral P06276 T52M 3O9M A T24M Disease Q12809 R56Q 2L0W A R56Q Disease P15056 K601Q 3SKC B K601Q Disease P04062 R170L 2WKL B R131L Disease P15941 S1142N 2ACM B S1142N Neutral P04062 K452Q 2WKL B K413Q Disease P15056 K601E 3SKC B K601E Disease P04062 A229E 2WKL B A190E Disease P38398 G1738R 1T15 A G1738R Disease Q5SRE7 R222W 3OBZ A R222W Neutral Q92838 A356V 1RJ7 A A356V Disease P79483 G115V 2Q6W B G86V Neutral P08709 T419M 2BZ6 H T210M Disease P20933 G252R 1APY B G229R Disease Q30154 L67V 1FV1 B L38V Neutral P79483 L37S 2Q6W B L8S Neutral P06276 F56I 3O9M A F28I Disease P79483 G115A 2Q6W B G86A Neutral P00451 W2248C 3HNY M W2229C Disease O15553 M680I 2WL1 A M680I Disease O15553 M680L 2WL1 A M680L Disease P08709 T332M 2BZ6 H T129CM Disease P00451 W2248S 3HNY M W2229S Disease P04062 V497L 2WKL B V458L Neutral P15735 E157K 2Y7J A E157K Disease P04062 L500P 2WKL B L461P Disease P08709 D398E 2BZ6 H D189E Disease Q13426 S12C 3SR2 A S12C Neutral P04439 G199R 2XPG A G175R Neutral P00742 P383S 3KL6 A P161S Disease P43632 V93D 3H8N A V72D Neutral P15056 D594G 3SKC B D594G Disease Q96DA0 M133V 3AQG A M133V Neutral P60174 G110A 2JK2 A G72A Disease P08686 K121Q 2GEG C K121Q Disease Q9Y3A5 N8K 2L9N A N8K Disease P08709 R375W 2BZ6 H R170CW Disease O15394 D347N 2XYC A D347N Neutral O43602 R183S 2XRP I R102S Disease P02545 L454P 1IVT A L454P Disease P04062 I200N 2WKL B I161N Disease P08709 L314V 2BZ6 H L114V Disease O95045 M78L 3P0F A M78L Neutral Q30154 R100A 1FV1 B R71A Neutral P04062 I200S 2WKL B I161S Disease P08709 C151S 2BZ6 L C91S Disease P06276 R543C 3O9M A R515C Disease Q12809 A78P 2L0W A A78P Disease P02042 P37H 1SHR B P36H Neutral Q9Y4U1 L193P 3SC0 A L193P Disease P00374 L80F 1KMV A L79F Disease P01909 Y34C 1S9V A Y9C Neutral O43602 S128R 2XRP I S47R Disease P06280 E358A 3GXP A E358A Disease P15056 G596V 3SKC B G596V Disease P04062 D513Y 2WKL B D474Y Disease O00391 H444R 3LLI A H444R Neutral P04062 F298L 2WKL B F259L Disease P06280 G171D 3GXP A G171D Disease P21333 P207L 3HOP B P207L Disease P08709 R350C 2BZ6 H R147C Disease P08709 N117D 2FLB L N57D Disease P00742 G289R 3KL6 A G69R Disease P04062 Y251H 2WKL B Y212H Disease P42575 R441G 1PYO B R294G Neutral Q9Y4X3 L96F 2KUM A L72F Neutral P06276 D98G 3O9M A D70G Disease Q6ISU1 V106I 3OF6 E V90I Neutral P00734 R431H 1EB1 H R73H Disease P55072 R159G 3QQ8 A R159G Disease P00742 E142K 2JKH L E102K Disease P00451 P2319S 3HNY M P2300S Disease P00451 F2279I 3HNY M F2260I Disease P53396 E175D 3MWE A E175D Neutral P05534 R205H 3NFN A R181H Neutral P00451 F2279C 3HNY M F2260C Disease P00451 P2319L 3HNY M P2300L Disease Q92547 N955S 3JVE A N955S Neutral P15735 G189E 2Y7J A G189E Disease P05107 L149P 3K6S B L127P Disease Q92769 Y315H 3MAX B Y319H Neutral P00451 W2290L 3HNY M W2271L Disease P02647 R197C 3R2P A R173C Neutral Q30154 A103L 1FV1 B A74L Neutral Q30154 A103E 1FV1 B A74E Neutral P04062 A495P 2WKL B A456P Disease P02545 R453P 1IVT A R453P Disease P40818 A827G 3N3K A A827G Neutral P00451 A2211P 3HNY M A2192P Disease Q16548 N39K 3MQP A N39K Neutral O43323 L162P 3N1G B L162P Disease P02545 T528K 1IVT A T528K Disease P69905 G19D 1IRD A G18D Neutral Q30154 D59H 1FV1 B D30H Neutral Q30154 D59G 1FV1 B D30G Neutral P04062 S405G 2WKL B S366G Disease P69905 G19R 1IRD A G18R Neutral P04062 S405N 2WKL B S366N Disease P08709 A354V 2BZ6 H A152V Disease P06276 V170M 3O9M A V142M Disease P46063 V102I 2WWY A V102I Neutral P15056 G469E 3SKC B G469E Disease P53634 W429C 2DJF C W405C Disease P04637 P47S 2L14 B P47S Neutral Q9P2F6 A522T 3MSX B A522T Neutral P15735 D215N 2Y7J A D215N Disease P04062 L213F 2WKL B L174F Disease P15056 E501G 3SKC B E501G Disease O15553 A744S 2WL1 A A744S Disease P17066 R173P 3FE1 C R173P Neutral P00558 C316R 2XE6 A C315R Disease P15056 E501K 3SKC B E501K Disease P04062 M400I 2WKL B M361I Disease P04062 Y457C 2WKL B Y418C Disease P49768 D333G 2KR6 A D333G Disease P00742 D322N 3KL6 A D102N Disease P35475 G219E 1Y24 A G219E Disease P08709 G240R 2BZ6 H G44R Disease P32754 A268V 3ISQ A A268V Disease P43632 A205S 3H8N A A184S Neutral P08709 E154K 2BZ6 L E94K Disease Q9Y4U1 R189S 3SC0 A R189S Disease P04062 V414L 2WKL B V375L Disease P06280 G43R 3GXP A G43R Disease P32322 R119H 2IZZ E R119H Disease P00451 I2204T 3HNY M I2185T Disease P00742 C390F 3KL6 A C168F Disease Q86XE5 C257G 3S5N A C257G Disease P06276 D198E 3O9M A D170E Disease P05534 T206A 3NFN A T182A Neutral P04062 P430L 2WKL B P391L Disease P04062 F255Y 2WKL B F216Y Disease P08709 P194T 2BZ6 L P134T Disease Q15465 T150K 3MXW A T150K Disease Q06520 A63P 3F3Y A A63P Neutral P01009 R63C 1QLP A R39C Neutral P08709 P194L 2BZ6 L P134L Disease P02545 W467R 1IVT A W467R Disease P04062 R324C 2WKL B R285C Disease P04062 R324H 2WKL B R285H Disease P35475 E276K 1Y24 A E276K Disease P04062 H201P 2WKL B H162P Disease P35475 P385R 1Y24 A P385R Disease P00451 Q2265R 3HNY M Q2246R Disease P01563 K46R 1ITF A K23R Neutral O15553 Y688C 2WL1 A Y688C Disease P02462 G1580R 1LI1 A G140R Disease P05106 G605S 3IJE B G579S Disease P15056 W531C 3SKC B W531C Disease P04062 A229T 2WKL B A190T Disease O15553 L649P 2WL1 A L649P Disease P01909 S161I 1S9V A S136I Neutral P50225 R213H 1Z28 A R213H Neutral P02042 G25D 1SHR B G24D Neutral P08686 I77T 2GEG C I77T Disease P01909 S161R 1S9V A S136R Neutral P02042 G70R 1SHR B G69R Neutral P20036 F191V 3LQZ A F160V Neutral P20036 W74C 3LQZ A W43C Neutral Q06124 E69Q 3TKZ A E69Q Disease P04062 H294Q 2WKL B H255Q Disease Q06124 E69K 3TKZ A E69K Disease Q71DI3 M91T 3AV1 A M90T Neutral P35475 N348K 1Y24 A N348K Disease P08686 G292D 2GEG C G292D Disease P05534 T187R 3NFN A T163R Neutral Q9UL51 R527Q 3U10 A R527Q Neutral Q9UG22 V74F 2XTM A V74F Neutral P15056 N580D 3SKC B N580D Disease P00742 R366C 3KL6 A R143C Disease P04062 I441T 2WKL B I402T Disease P06280 L414S 3GXP A L414S Disease P04062 I441F 2WKL B I402F Disease Q06124 D61Y 3TKZ A D61Y Disease P38398 S1715R 1T15 A S1715R Disease Q06124 D61V 3TKZ A D61V Disease Q06124 D61N 3TKZ A D61N Disease P08686 R369W 2GEG C R369W Disease P05534 E86G 3NFN A E62G Neutral O15394 L350P 2XYC A L350P Neutral P08709 Y128C 2FLB L Y68C Disease P04439 G131W 2XPG A G107W Neutral P08709 S171F 2BZ6 L S111F Disease O15553 T681I 2WL1 A T681I Disease P20933 T322I 1APY B T299I Neutral P19544 F364L 1LU6 A F363L Disease P35240 C133R 1H4R A C133R Disease P04062 V437L 2WKL B V398L Disease P04062 N431I 2WKL B N392I Disease Q8WXF7 R415W 3Q5E A R415W Disease Q30154 Y89S 1FV1 B Y60S Neutral P04062 K237E 2WKL B K198E Disease P22681 D390Y 1FBV A D390Y Disease O15194 V132G 2HHL A V54G Neutral Q86XE5 G287V 3S5N A G287V Disease P08709 D277N 2BZ6 H D77N Disease P29317 T940I 3KKA C T939I Disease O15553 P758S 2WL1 A P758S Disease P01909 A182D 1S9V A A157D Neutral P02042 A23E 1SHR B A22E Neutral P04062 D419H 2WKL B D380H Disease P05107 Q354H 3K6S B Q332H Neutral P04062 D419N 2WKL B D380N Disease P04062 D419A 2WKL B D380A Disease Q96PD4 S95L 1JPY A S65L Disease P49761 Q607R 2WU6 A Q459R Neutral O60494 P1297L 3KQ4 B P1297L Disease Q9HD40 A239T 3HL2 A A239T Disease P04062 R535C 2WKL B R496C Disease O43602 N141D 2XRP I N60D Disease P04062 P221T 2WKL B P182T Disease P00747 L147P 1CEA A L45P Disease P04062 P221L 2WKL B P182L Disease P06276 L153F 3O9M A L125F Disease P79483 V193F 2Q6W B V164F Neutral P04062 K342I 2WKL B K303I Disease P08709 P363H 2BZ6 H P161H Disease Q30154 V114A 1FV1 B V85A Neutral P11473 R73Q 1KB2 A R73Q Disease P06276 Y156C 3O9M A Y128C Disease P38398 M1689R 1T15 A M1689R Disease P08709 P363R 2BZ6 H P161R Disease P32754 A33T 3ISQ A A33T Neutral P20036 L158P 3LQZ A L127P Neutral P01909 K197Q 1S9V A K172Q Neutral P04439 D185E 2XPG A D161E Neutral P01909 K197E 1S9V A K172E Neutral O15553 D661N 2WL1 A D661N Disease Q9NRG4 G165E 3TG4 A G165E Neutral P05534 F123Y 3NFN A F99Y Neutral Q16548 C19Y 3MQP A C19Y Neutral Q13126 V56I 3OZC A V56I Neutral P07359 M255V 1GWB A M255V Disease Q12809 T65P 2L0W A T65P Disease P20036 L97S 3LQZ A L66S Neutral P02766 A129T 3M1O A A109T Disease P15529 W216C 3O8E B W182C Disease P53634 E401K 2DJF C E377K Neutral P04062 G228V 2WKL B G189V Disease P49768 G384A 2KR6 A G384A Disease P20036 Q81R 3LQZ A Q50R Neutral P04000 G338E 1KPX A G338E Disease P05534 M121R 3NFN A M97R Neutral Q92838 C346Y 1RJ7 A C346Y Disease Q02127 R135C 2FPV A R136C Disease P00451 I2281T 3HNY M I2262T Disease P49768 A409T 2KR6 A A409T Disease P02042 F86S 1SHR B F85S Neutral Q9BZS1 A384T 3QRF F A384T Disease P00742 C151Y 2JKH L C111Y Disease Q9UQ84 V76I 3QEB Z V76I Neutral Q08493 R344W 1LXU A R39W Neutral P15056 N581D 3SKC B N581D Disease Q02127 R346W 2FPV A R347W Disease P35555 G1594D 1UZJ A G1594D Disease P08709 L323R 2BZ6 H L123R Disease P04439 I121M 2XPG A I97M Neutral Q99551 A231T 3MVA O A231T Neutral O14931 A103T 3PV6 B A103T Neutral P00451 I2336F 3HNY M I2317F Disease Q12809 L86R 2L0W A L86R Disease P06396 N231D 1KCQ A N204D Neutral P00742 R327W 3KL6 A R107W Disease P84022 R287W 1MK2 A R286W Disease P32754 R113Q 3ISQ A R113Q Neutral P50225 R37Q 1Z28 A R37Q Neutral P04001 R330Q 1KPW A R330Q Disease P07359 C225S 1GWB A C225S Disease P04062 Y244C 2WKL B Y205C Disease P08709 G435E 2BZ6 H G226E Disease Q15465 S156R 3MXW A S156R Disease P55072 R155P 3QQ8 A R155P Disease P00558 D315N 2XE6 A D314N Disease P11473 R50Q 1KB2 A R50Q Disease P15924 I305F 3R6N A I305F Neutral P55072 R155H 3QQ8 A R155H Disease P55072 R155C 3QQ8 A R155C Disease P04062 N501K 2WKL B N462K Disease Q04656 R844H 2KIJ A R39H Disease P04062 R398Q 2WKL B R359Q Disease Q30154 G115V 1FV1 B G86V Neutral O15553 G678E 2WL1 A G678E Disease P45452 M91T 1UC1 A M91T Disease P00740 S169C 2WPH E S123C Disease P02545 R343Q 1X8Y A R343Q Disease P04062 T362I 2WKL B T323I Disease P49768 P436Q 2KR6 A P436Q Disease P49768 P436S 2KR6 A P436S Disease P35555 C1564S 1UZJ A C1564S Disease P13929 A85V 2XSX A A85V Neutral Q92838 L296V 1RJ7 A L296V Disease P01909 L98V 1S9V A L73V Neutral Q8WXF7 N355K 3Q5E A N355K Disease P06280 S201F 3GXP A S201F Disease P84022 T261I 1MK2 A T260I Disease P01909 L98M 1S9V A L73M Neutral P29317 G948W 3KKA C G947W Disease P06276 F502L 3O9M A F474L Disease Q9Y4U1 W157C 3SC0 A W157C Disease Q12809 N33T 2L0W A N33T Disease P04062 P217S 2WKL B P178S Disease P15056 L525P 3SKC B L525P Disease P00740 C170F 2WPH E C124F Disease P04062 C55S 2WKL B C16S Disease P04062 K464E 2WKL B K425E Disease P01130 W87G 1LDR A W24G Disease Q9UHL4 A89G 3JYH A A89G Neutral P69892 K121Q 1FDH G K120Q Neutral P13929 S71N 2XSX A S71N Neutral P04062 G429R 2WKL B G390R Disease Q9UG22 H161R 2XTM A H161R Neutral Q15465 D171H 3MXW A D171H Disease P04062 A129T 2WKL B A90T Disease P38398 T1685A 1T15 A T1685A Disease P42330 E77G 1S1P A E77G Neutral P68871 V2A 1IRD B V201A Neutral P06280 G328V 3GXP A G328V Disease Q02127 R244W 2FPV A R245W Disease P45452 H232N 3ZXH B H232N Disease P38398 M1775K 1T15 A M1775K Disease Q07889 G434K 1AWE A G34K Disease P02545 G449D 1IVT A G449D Disease P21333 C210F 3HOP B C210F Disease P32322 A189V 2IZZ E A189V Neutral P02042 D100N 1SHR B D99N Neutral P17066 P65T 3FE1 C P65T Neutral P00451 L2229F 3HNY M L2210F Disease P79483 R103Q 2Q6W B R74Q Neutral P10746 P248Q 1JR2 A P248Q Disease P06280 G360C 3GXP A G360C Disease O75531 A12T 2BZF A A12T Disease P04062 H490R 2WKL B H451R Disease P04070 G114R 3F6U L G72R Disease P07602 T217I 1N69 A T23I Disease P35475 T103P 1Y24 A T103P Disease P05107 R586W 3K6S B R564W Disease P69905 D7A 1IRD A D6A Neutral P01909 Q76K 1S9V A Q50K Neutral P11473 K45E 1KB2 A K45E Disease Q8WVQ1 R300H 1S1D A R230H Disease Q15465 L109F 3MXW A L109F Disease Q8WVQ1 R300C 1S1D A R230C Disease P60174 E142D 2JK2 A E104D Disease P49768 S390I 2KR6 A S390I Disease Q30154 Y107V 1FV1 B Y78V Neutral Q8N5Z0 V243I 2R2N A V243I Neutral P08709 G216D 2BZ6 H G19D Disease P02042 R117H 1SHR B R116H Neutral P02042 R117C 1SHR B R116C Neutral P06276 E488K 3O9M A E460K Disease O14773 P544S 3EDY A P544S Disease Q495A1 I33V 3Q0H B I33V Neutral Q9P0N9 A136T 3QWL A A136T Neutral P48551 I196V 2KZ1 B I169V Neutral P48436 H165Q 1SX9 A H65Q Disease O43602 A152S 2XRP I A71S Disease O43602 G181A 2XRP I G100A Disease P04062 G460D 2WKL B G421D Disease P43632 P89R 3H8N A P68R Neutral P17066 A150T 3FE1 C A150T Neutral Q9NZK5 H335R 3LGD A H309R Neutral Q9H9E3 R729W 3HR0 A R729W Disease Q9NVQ4 L127S 2KW1 A L37S Neutral P35219 S100P 2W2J A S100P Disease Q02127 D392G 2FPV A D393G Disease Q9NRK6 R242G 2YL4 A R242G Neutral P01130 G592E 1LRX B G592E Disease P18075 N321S 1M4U L N29S Neutral Q16772 A208T 2VCV A A208T Neutral O75715 L85P 2I3Y A L85P Neutral Q8WXF7 H247P 3Q5E A H247P Disease Q12809 F29L 2L0W A F29L Disease P04062 L303I 2WKL B L264I Disease P10144 R55Q 1IAU A R48Q Neutral Q9H0F7 A89V 2H57 A A89V Disease Q9Y4U1 L116P 3SC0 A L116P Disease P69905 A13D 1IRD A A12D Neutral Q06210 M509T 2ZJ3 A M490T Disease P20333 M196R 3ALQ R M174R Neutral P02545 R386K 1X8Y A R386K Disease O15553 I720M 2WL1 A I720M Disease P05106 C568R 3IJE B C542R Disease Q92838 W274R 1RJ7 A W274R Disease P04062 R159W 2WKL B R120W Disease P69891 R41K 1I3D A R40K Neutral P04062 R159Q 2WKL B R120Q Disease P55210 D255E 2QL9 B D255E Neutral P05107 G284S 3K6S B G262S Disease Q30154 F96I 1FV1 B F67I Neutral Q30154 R100T 1FV1 B R71T Neutral Q30154 F96L 1FV1 B F67L Neutral Q14623 E131K 3K7G B E131K Disease P20036 T114A 3LQZ A T83A Neutral Q13224 R682C 1S11 B R682C Disease P48436 P170L 1SX9 A P70L Disease P04062 G428E 2WKL B G389E Disease P04062 I158T 2WKL B I119T Disease Q8TDB6 K668M 3PG6 A K668M Neutral P04062 I158S 2WKL B I119S Disease P35555 D1487A 1UZJ A D1487A Disease P08709 A251T 2BZ6 H A55T Disease P08709 A251P 2BZ6 H A55P Disease P08709 G432D 2BZ6 H G223D Disease P55201 H1193Q 3L42 A H1193Q Neutral Q30201 R224Q 1A6Z A R202Q Neutral Q9P0N9 L67W 3QWL A L67W Neutral P01909 Y175H 1S9V A Y150H Neutral P68871 A11D 1IRD B A210D Neutral P17066 D154N 3FE1 C D154N Neutral P15735 E247G 2Y7J A E247G Neutral Q06124 T59A 3TKZ A T59A Disease P19878 Q169E 1E96 B Q169E Disease Q12809 C66G 2L0W A C66G Disease P04062 T270R 2WKL B T231R Disease Q30154 R100G 1FV1 B R71G Neutral O15553 R653H 2WL1 A R653H Disease O15553 S675N 2WL1 A S675N Disease P68871 H3R 1IRD B H202R Neutral P15056 G464E 3SKC B G464E Disease P68871 H3Y 1IRD B H202Y Neutral P04062 Y352H 2WKL B Y313H Disease P32754 I267F 3ISQ A I267F Neutral Q15465 E53K 3MXW A E53K Disease P04062 N156D 2WKL B N117D Disease P08709 G425C 2BZ6 H G216C Disease P08709 G425A 2BZ6 H G216A Disease P09622 K104T 3RNM A K69T Neutral Q07889 M422V 1AWE A M22V Disease O43602 G148E 2XRP I G67E Disease O15553 E656A 2WL1 A E656A Disease Q8IWV7 H136R 3NY1 B H136R Disease P04062 V433L 2WKL B V394L Disease P06280 A285P 3GXP A A285P Disease P05164 Y173C 1D2V A Y7C Disease P02042 G26D 1SHR B G25D Neutral P20036 P127A 3LQZ A P96A Neutral Q9Y4U1 G147D 3SC0 A G147D Disease O15553 F743L 2WL1 A F743L Disease Q15080 R105Q 1H6H A R105Q Disease Q9Y5Z4 R140Q 3R8J A R140Q Neutral P68871 W16R 1IRD B W215R Neutral P38398 I1766S 1T15 A I1766S Disease P08709 G157C 2BZ6 L G97C Disease P06276 W499R 3O9M A W471R Disease P32322 A179T 2IZZ E A179T Disease P98066 Q144R 2WNO A Q144R Neutral P08709 G157S 2BZ6 L G97S Disease P68871 S10C 1IRD B S209C Neutral O95257 G112S 3FFM A G112S Neutral P01909 F77L 1S9V A F51L Neutral P69905 E24G 1IRD A E23G Neutral Q8IXQ5 H423Y 3II7 A H423Y Neutral P79483 Y59H 2Q6W B Y30H Neutral P04062 P198L 2WKL B P159L Disease P20702 W48R 3K6S A W29R Neutral P01130 I451T 1LRX B I451T Disease P04062 P198T 2WKL B P159T Disease P06280 H46P 3GXP A H46P Disease P69892 H93Y 1FDH G H92Y Disease P08709 L321F 2BZ6 H L121F Disease O43602 Y206H 2XRP I Y125H Disease P06400 H673P 1GUX B H673P Disease P02042 N118D 1SHR B N117D Neutral O43602 Y206D 2XRP I Y125D Disease P20702 P517R 3K6S A P498R Neutral P02042 E122V 1SHR B E121V Neutral P05107 G169R 3K6S B G147R Disease P05106 C532Y 3IJE B C506Y Disease P21333 L172F 3HOP B L172F Disease P04062 R296Q 2WKL B R257Q Disease P49761 R628W 2WU6 A R480W Neutral P01909 S97I 1S9V A S72I Neutral Q9Y3A5 I87S 2L9N A I87S Disease P08709 C195R 2BZ6 L C135R Disease P68871 E8K 1IRD B E207K Neutral P69891 W38G 1I3D A W37G Neutral P50225 E151D 1Z28 A E151D Neutral P04062 M162V 2WKL B M123V Disease P11473 F47I 1KB2 A F47I Disease P06276 A356D 3O9M A A328D Disease P50225 E151Q 1Z28 A E151Q Neutral P43632 H71R 3H8N A H50R Neutral P06280 R356Q 3GXP A R356Q Disease P04062 R170C 2WKL B R131C Disease Q07889 P478R 1AWE A P78R Disease P17066 V336F 3FE1 C V336F Neutral P00740 Q167H 2WPH E Q121H Disease Q9BTZ2 P202S 3O4R A P202S Neutral P27930 E292K 3O4O C E279K Neutral P60174 C79Y 2JK2 A C41Y Disease P08709 R364Q 2BZ6 H R162Q Disease P08709 R364W 2BZ6 H R162W Disease P22061 V120I 1I1N A V119I Neutral P16444 E351Q 1ITU A E335Q Neutral P20036 N100D 3LQZ A N69D Neutral P01909 T67A 1S9V A T41A Neutral Q02127 G202D 2FPV A G203D Disease Q02127 G202A 2FPV A G203A Disease O15553 G632S 2WL1 A G632S Disease P79483 R58I 2Q6W B R29I Neutral P02042 V2A 1SHR B V1A Neutral O14964 T7S 3ZYQ A T7S Neutral P16444 E351K 1ITU A E335K Neutral P02545 W520S 1IVT A W520S Disease O15553 R761H 2WL1 A R761H Disease Q06210 R452H 2ZJ3 A R433H Disease P69905 K8E 1IRD A K7E Neutral P35475 E178K 1Y24 A E178K Disease P05107 P178L 3K6S B P156L Disease P00742 G406S 3KL6 A G184S Disease P04062 N421K 2WKL B N382K Disease P08709 G402E 2BZ6 H G193E Disease P04062 R535H 2WKL B R496H Disease P08709 G402R 2BZ6 H G193R Disease O95292 P56S 3IKK A P56S Disease P08686 I230T 2GEG C I230T Disease P60174 V269M 2JK2 A V231M Disease P17066 N153S 3FE1 C N153S Neutral Q9UQ84 R93G 3QEB Z R93G Neutral P69905 K17N 1IRD A K16N Neutral P41235 E285Q 3FS1 A E276Q Disease P69905 K17M 1IRD A K16M Neutral P32929 Q240E 3COG D Q240E Disease P38398 M18T 1JM7 A M18T Disease P79483 Q178H 2Q6W B Q149H Neutral P08709 G156S 2BZ6 L G96S Disease P06276 D98H 3O9M A D70H Disease O60494 Y1032H 3KQ4 B Y1032H Neutral Q6ZMT4 D392Y 3KV9 A D392Y Neutral P56817 V265A 2QP8 A V265A Neutral P06276 K295R 3O9M A K267R Disease P08709 A429T 2BZ6 H A221T Disease P00558 G158V 2XE6 A G157V Disease P04062 A380T 2WKL B A341T Disease P08709 R307C 2BZ6 H R107C Disease P02042 E91V 1SHR B E90V Neutral P69905 D7N 1IRD A D6N Neutral P08709 R307H 2BZ6 H R107H Disease O43602 R159L 2XRP I R78L Disease Q9BZS1 I363V 3QRF F I363V Disease P33764 R3K 3NSO A R3K Neutral Q8WXF7 S259Y 3Q5E A S259Y Disease Q92838 T338M 1RJ7 A T338M Disease Q8WXF7 M408V 3Q5E A M408V Disease O60844 S32G 3APA A S32G Neutral P55072 R159H 3QQ8 A R159H Disease P04070 G145R 3F6U L G103R Disease P35555 I2185T 1EMN A I2185T Disease P43632 P92H 3H8N A P71H Neutral O15553 M694L 2WL1 A M694L Disease O15553 M694I 2WL1 A M694I Disease P04062 C381G 2WKL B C342G Disease P08709 I198T 2BZ6 L I138T Disease P15924 I445V 3R6N A I445V Disease P01130 C358Y 1HJ7 A C337Y Disease P19544 G379C 1LU6 A G378C Disease P06276 E283D 3O9M A E255D Neutral O15553 M694V 2WL1 A M694V Disease P79483 R84L 2Q6W B R55L Neutral P69905 H21R 1IRD A H20R Neutral P01909 E183D 1S9V A E158D Neutral P04062 T173P 2WKL B T134P Disease P69905 H21Q 1IRD A H20Q Neutral Q9HD40 Y334C 3HL2 A Y334C Disease P04062 T173I 2WKL B T134I Disease P04439 R89G 2XPG A R65G Neutral P04062 L509P 2WKL B L470P Neutral P04062 G241E 2WKL B G202E Disease P79483 E38Q 2Q6W B E9Q Neutral P05108 E314K 3N9Y A E275K Neutral P04062 G241R 2WKL B G202R Disease P22888 I152T 1LUT A I152T Disease P04062 D166V 2WKL B D127V Disease Q9UJ71 W264R 3P7F B W264R Disease P06400 E746G 1GUX B E746G Neutral P15056 F468S 3SKC B F468S Disease P05106 C586F 3IJE B C560F Disease P08709 R413G 2BZ6 H R204G Disease P20036 K142R 3LQZ A K111R Neutral P49768 C410Y 2KR6 A C410Y Disease P05106 C586R 3IJE B C560R Disease P00451 R2228P 3HNY M R2209P Disease P05107 D128Y 3K6S B D106Y Disease P00749 I214M 3IG6 B I47M Neutral P05107 D128N 3K6S B D106N Disease P01130 V523M 1LRX B V523M Neutral P08709 C238Y 2BZ6 H C42Y Disease Q06124 Y62D 3TKZ A Y62D Disease P04439 Q94H 2XPG A Q70H Neutral P79483 L67A 2Q6W B L38A Neutral P08709 L264P 2BZ6 H L64P Disease P13929 G374E 2XSX A G374E Disease P79483 L67V 2Q6W B L38V Neutral P15056 S467A 3SKC B S467A Disease P20036 P49T 3LQZ A P18T Neutral Q02318 A169V 1MFX A A136V Neutral P20036 A42M 3LQZ A A11M Neutral P07602 N215K 1N69 A N21K Disease P07602 N215H 1N69 A N21H Disease P69905 A20E 1IRD A A19E Neutral Q13426 A56T 3SR2 A A56T Neutral P20036 A42V 3LQZ A A11V Neutral P20036 A42T 3LQZ A A11T Neutral P21333 S149F 3HOP B S149F Disease O15553 I591T 2WL1 A I591T Disease Q9Y5N6 P138Q 3M03 A P138Q Neutral P06276 A229T 3O9M A A201T Disease P69905 G23D 1IRD A G22D Neutral P00451 S2192I 3HNY M S2173I Disease Q16653 S133C 1Q70 A S104C Disease P00451 R2339T 3HNY M R2320T Disease P08709 G343S 2BZ6 H G140S Disease P00558 D285V 2XE6 A D284V Disease Q06124 E76V 3TKZ A E76V Disease Q06124 E76K 3TKZ A E76K Disease O60494 L969V 3KQ4 B L969V Neutral Q14623 D100N 3K7G B D100N Disease Q06124 E76A 3TKZ A E76A Disease Q06124 E76G 3TKZ A E76G Disease Q14623 D100E 3K7G B D100E Disease P53634 H405R 2DJF C H381R Disease P00740 G160E 2WPH E G114E Disease P06400 C712R 1GUX B C712R Disease P69891 T13R 1I3D A T12R Neutral P17066 R260H 3FE1 C R260H Neutral P06276 Y61C 3O9M A Y33C Disease P45452 F74S 1UC1 A F74S Disease O15409 R553H 2A07 F R553H Disease P15056 G466V 3SKC B G466V Disease P04439 R169H 2XPG A R145H Neutral P08709 G177R 2BZ6 L G117R Disease P79483 K41T 2Q6W B K12T Neutral P35544 T53I 2L7R A T53I Neutral P69891 D23G 1I3D A D22G Neutral Q99551 A294T 3MVA O A294T Neutral P08709 D302H 2BZ6 H D102H Disease P08709 D302N 2BZ6 H D102N Disease Q02127 G152R 2FPV A G153R Disease P42574 E190D 2XYG B E190D Neutral P01024 R592W 3G6J A R570W Disease P21333 D203Y 3HOP B D203Y Disease P04062 V391L 2WKL B V352L Disease P01024 R592Q 3G6J A R570Q Disease Q8WXF7 H258R 3Q5E A H258R Disease P06276 E525V 3O9M A E497V Disease P00451 T2264A 3HNY M T2245A Disease P32322 G206R 2IZZ E G206R Disease O15194 S121P 2HHL A S43P Neutral P01909 Q76R 1S9V A Q50R Neutral P00742 T358M 3KL6 A T135M Disease P43632 N68D 3H8N A N47D Neutral P08174 S199L 1H03 P S43L Neutral P05164 M251T 1D2V A M85T Disease P01909 L178F 1S9V A L153F Neutral P08709 K197E 2BZ6 L K137E Disease P00451 P2196R 3HNY M P2177R Disease Q8WXF7 E66Q 3Q5E A E66Q Disease P08686 L142P 2GEG C L142P Disease P08686 R233K 2GEG C R233K Disease Q15465 G27A 3M1N A G27A Disease P04439 G186A 2XPG A G162A Neutral P01909 P81R 1S9V A P56R Neutral P04637 K292I 2AC0 A K292I Disease P69892 V68M 1FDH G V67M Disease P69905 A14P 1IRD A A13P Neutral Q15465 C102Y 3MXW A C102Y Disease Q9UL52 Y303C 2OQ5 A Y128C Neutral Q15465 C102R 3MXW A C102R Disease P14324 V364A 3N45 F V298A Neutral P01009 S77F 1QLP A S53F Neutral P04062 G85E 2WKL B G46E Disease P04062 P161S 2WKL B P122S Disease P00742 E304K 3KL6 A E84K Disease P79483 R218S 2Q6W B R189S Neutral Q8WXF7 F193C 3Q5E A F193C Neutral P53634 E447G 2DJF C E423G Disease P15941 V1117M 2ACM B V1117M Neutral P01130 D433H 1LRX B D433H Disease Q9Y3A5 K67E 2L9N A K67E Disease P04062 V230E 2WKL B V191E Disease Q8WUN7 M129I 2KSN A M129I Neutral P05107 K196T 3K6S B K174T Disease P05107 A239T 3K6S B A217T Disease P15529 C35Y 3O8E B C1Y Disease P49761 R486C 2WU6 A R338C Neutral P04062 R392W 2WKL B R353W Disease P04062 R392G 2WKL B R353G Disease Q9BZS1 F371C 3QRF F F371C Disease P15056 D638E 3SKC B D638E Disease P04439 S129P 2XPG A S105P Neutral Q07157 N471S 3TSV A N471S Neutral P08709 D272N 2BZ6 H D72N Disease Q05086 R62H 2KR1 A R39H Neutral P04062 N227S 2WKL B N188S Disease P04062 S146L 2WKL B S107L Disease P04062 N227K 2WKL B N188K Disease P01130 D579Y 1LRX B D579Y Disease P35475 G265R 1Y24 A G265R Disease P79483 Y55L 2Q6W B Y26L Neutral P42768 A236E 1CEE B A7E Disease P79483 Y55F 2Q6W B Y26F Neutral P04062 A357D 2WKL B A318D Disease P01130 D415G 1LRX B D415G Disease Q07889 I437T 1AWE A I37T Disease P46063 D495H 2WWY A D495H Neutral P63316 C84Y 1AP4 A C84Y Disease Q30154 D99G 1FV1 B D70G Neutral Q30154 D99E 1FV1 B D70E Neutral Q30154 D99H 1FV1 B D70H Neutral Q30154 D99N 1FV1 B D70N Neutral Q30154 D99R 1FV1 B D70R Neutral Q30154 D99Q 1FV1 B D70Q Neutral P36897 N45S 1TBI A N12S Disease Q9NRG4 I430M 3TG4 A I430M Neutral P00451 R2323L 3HNY M R2304L Disease P00451 R2323H 3HNY M R2304H Disease P79483 S89Y 2Q6W B S60Y Neutral P00451 R2323G 3HNY M R2304G Disease P00451 R2323C 3HNY M R2304C Disease Q9UQ84 N299S 3QEB Z N299S Neutral P49768 N405S 2KR6 A N405S Disease P79483 S89H 2Q6W B S60H Neutral P08709 Y437F 2BZ6 H Y228F Disease P53634 H127P 2DJF A H103P Disease P08709 V312M 2BZ6 H V112M Disease P04439 N151K 2XPG A N127K Neutral P04062 F290L 2WKL B F251L Disease P06400 C706Y 1GUX B C706Y Disease P02545 M371K 1X8Y A M371K Disease Q30154 D66N 1FV1 B D37N Neutral P04062 T82I 2WKL B T43I Disease P00742 C149Y 2JKH L C109Y Disease P08709 V341F 2BZ6 H V138F Disease P46063 K487T 2WWY A K487T Neutral P04062 N409S 2WKL B N370S Disease P06400 R661W 1GUX B R661W Disease P15056 G469R 3SKC B G469R Disease P15056 R462I 3SKC B R462I Disease P15056 G469A 3SKC B G469A Disease P69892 F42S 1FDH G F41S Disease P05108 R353W 3N9Y A R314W Disease P06400 L662P 1GUX B L662P Disease P48436 K173E 1SX9 A K73E Disease P02042 P52R 1SHR B P51R Neutral P01909 V73E 1S9V A V47E Neutral P04062 G152E 2WKL B G113E Disease P02753 I59N 1JYD A I41N Disease P06276 L335P 3O9M A L307P Disease P00519 L140P 3K2M A L159P Neutral P02042 H3R 1SHR B H2R Neutral P01024 F603V 3G6J A F581V Disease P01130 E101K 1LDR A E38K Disease P63316 L29Q 1AP4 A L29Q Disease Q9Y3A5 R169C 2L9N A R169C Disease O00391 A294S 3LLI A A294S Neutral P08709 C370F 2BZ6 H C168F Disease P49768 G378E 2KR6 A G378E Disease P32754 Y160C 3ISQ A Y160C Disease Q15465 L39P 3MXW A L39P Disease P49768 L392V 2KR6 A L392V Disease Q13426 E142Q 3Q4F C E142Q Neutral P04062 D63N 2WKL B D24N Disease P06276 G418V 3O9M A G390V Disease P04062 W223R 2WKL B W184R Disease P02545 L380S 1X8Y A L380S Disease Q8WXF7 L157W 3Q5E A L157W Disease P04062 F450I 2WKL B F411I Disease P00742 A152T 2JKH L A112T Neutral P08709 C254R 2BZ6 H C58R Disease P08709 C254Y 2BZ6 H C58Y Disease P00558 L88P 2XE6 A L87P Disease P04062 L410V 2WKL B L371V Disease Q16548 E117D 3MQP A E117D Neutral P11473 G46D 1KB2 A G46D Disease P26998 H113D 3QK3 B H113D Neutral Q96DN0 F52L 2L4C A F27L Neutral Q12809 P72Q 2L0W A P72Q Disease Q9BQB4 C167R 2K8P A C143R Disease Q9Y3A5 E44G 2L9N A E44G Disease P55201 G1117E 3L42 A G1117E Neutral P01909 F83G 1S9V A F58G Neutral P55212 A109T 3P45 A A109T Neutral Q06210 M510T 2ZJ3 A M491T Disease P08709 S404N 2BZ6 H S195N Disease P04062 S276P 2WKL B S237P Disease P04062 D179H 2WKL B D140H Disease Q9Y4U1 R206W 3SC0 A R206W Disease Q9Y4U1 R206P 3SC0 A R206P Disease P02545 N456D 1IVT A N456D Disease P69905 A22D 1IRD A A21D Neutral P69905 W15R 1IRD A W14R Neutral Q9Y4U1 G147A 3SC0 A G147A Disease P46531 V1671I 3I08 B V1672I Neutral P06276 Q546L 3O9M A Q518L Disease P69905 A22P 1IRD A A21P Neutral Q9H3R0 E206D 2XML A E206D Neutral Q15465 F170C 3MXW A F170C Disease P06132 K15E 1R3Q A K15E Neutral P08709 R326Q 2BZ6 H R126Q Disease Q15465 I84F 3MXW A I84F Disease P00451 W2332R 3HNY M W2313R Disease P02042 N58K 1SHR B N57K Neutral P08709 G345S 2BZ6 H G142S Disease P04439 D101N 2XPG A D77N Neutral P00734 R425C 1EB1 H R67C Disease P78417 C32Y 1EEM A C32Y Neutral P07738 R62Q 2H4X A R62Q Disease Q06124 E76D 3TKZ A E76D Disease P00451 R2228G 3HNY M R2209G Disease P00451 R2228L 3HNY M R2209L Disease O43602 D167H 2XRP I D86H Disease P49418 K218E 4A3A A K218E Neutral P00451 R2228Q 3HNY M R2209Q Disease P15056 F595L 3SKC B F595L Disease O75326 S115T 3NVQ A S115T Neutral O43602 R170G 2XRP I R89G Disease P00734 R314H 3E6P L R271H Disease Q06210 D366Y 2ZJ3 A D347Y Disease P00734 R314C 3E6P L R271C Disease P01009 G91E 1QLP A G67E Neutral P01130 L479P 1LRX B L479P Disease P08709 A304T 2BZ6 H A104T Disease P08709 A304V 2BZ6 H A104V Disease P08709 T298I 2BZ6 H T98I Disease P04062 G364R 2WKL B G325R Disease P08709 L125P 2FLB L L65P Disease Q07889 T549K 1AWE A T149K Disease P08709 H408Q 2BZ6 H H199Q Disease P08709 H408R 2BZ6 H H199R Disease Q9Y4X3 I78V 2KUM A I54V Neutral P01909 L71W 1S9V A L45W Neutral P26998 G165R 3QK3 B G165R Disease P08246 A166T 2Z7F E A152T Disease P08709 L360P 2BZ6 H L158P Disease P19878 N42S 1E96 B N42S Disease P79483 N106T 2Q6W B N77T Neutral P32322 R119G 2IZZ E R119G Disease P08246 C71R 2Z7F E C58R Neutral O75326 R461C 3NVQ A R461C Neutral P04062 G517S 2WKL B G478S Disease P08709 L181P 2BZ6 L L121P Disease Q9Y4U1 Y130H 3SC0 A Y130H Disease P00492 C23W 1BZY A C22W Disease P04062 V54L 2WKL B V15L Disease P04062 E80K 2WKL B E41K Disease P53634 H405N 2DJF C H381N Disease P08709 W344R 2BZ6 H W141R Disease P06280 E338K 3GXP A E338K Disease Q30154 S164G 1FV1 B S135G Neutral P08709 S186F 2BZ6 L S126F Disease Q02127 T284I 2FPV A T285I Disease P02545 N456K 1IVT A N456K Disease Q15465 V124M 3MXW A V124M Disease P05106 G598S 3IJE B G572S Disease P15056 Q709R 3SKC B Q709R Disease Q9UQ84 A137S 3QEB Z A137S Neutral Q6GTX8 E63D 3KGR B E63D Neutral Q92743 A252T 3NZI A A252T Disease P01130 N564S 1LRX B N564S Disease ___________________________________________________