Cluster PDB Chain Mutation Effect A4D256 1OHC A I341T Neutral A4D256 1OHC A T341I *Neutral A6NKC4 1E4J A A57D Neutral A6NKC4 1E4J A D57A *Neutral A6NKC4 1E4J A D61N *Neutral A6NKC4 1E4J A N61D Neutral A6NKC4 1E4J A R15S *Neutral A6NKC4 1E4J A S15R Neutral A6NKQ9 1HCN B D77N *Neutral A6NKQ9 1HCN B H10R *Neutral A6NKQ9 1HCN B I15T *Neutral A6NKQ9 1HCN B N77D Neutral A6NKQ9 1HCN B R10H Neutral A6NKQ9 1HCN B T15I Neutral A6NKQ9 1M92 A I15M *Neutral A6NKQ9 1M92 A I35T Neutral A6NKQ9 1M92 A M15I Neutral A6NKQ9 1M92 A R28W *Neutral A6NKQ9 1M92 A T35I *Neutral A6NKQ9 1M92 A W28R Neutral A6NKQ9 1M92 A G122S Neutral A6NKQ9 1M92 A S122G *Neutral O00182 2ZHN A G5S Neutral O00182 2ZHN A S5G *Neutral O00206 3FXI A A175T *Neutral O00206 3FXI A C246S Neutral O00206 3FXI A C306W Neutral O00206 3FXI A D299G Neutral O00206 3FXI A E474K Neutral O00206 3FXI A F342Y Neutral O00206 3FXI A F385L *Neutral O00206 3FXI A F443L Neutral O00206 3FXI A G299D *Neutral O00206 3FXI A G310V *Neutral O00206 3FXI A H510Q *Neutral O00206 3FXI A I399T *Neutral O00206 3FXI A K474E *Neutral O00206 3FXI A L385F Neutral O00206 3FXI A L443F *Neutral O00206 3FXI A N329S Neutral O00206 3FXI A N400S *Neutral O00206 3FXI A Q188R Neutral O00206 3FXI A Q510H Neutral O00206 3FXI A R188Q *Neutral O00206 3FXI A S246C *Neutral O00206 3FXI A S329N *Neutral O00206 3FXI A S400N Neutral O00206 3FXI A T175A Neutral O00206 3FXI A T399I Neutral O00206 3FXI A V310G Neutral O00206 3FXI A W306C *Neutral O00206 3FXI A Y342F *Neutral O00602 2D39 C H126Y *Neutral O00602 2D39 C Y126H Neutral O00716 2AZE B H252R *Neutral O00716 2AZE B M276V *Neutral O00716 2AZE B R252H Neutral O00716 2AZE B V276M Neutral O14625 1RJT A N34S Neutral O14625 1RJT A S34N *Neutral O14757 2E9U A E223V Neutral O14757 2E9U A Q156R *Neutral O14757 2E9U A R156Q Neutral O14757 2E9U A V223E *Neutral O14773 3EDY A G77R Disease O14773 3EDY A L62S *Neutral O14773 3EDY A S62L Neutral O14773 3EDY A A454E Disease O14773 3EDY A C185R *Neutral O14773 3EDY A C365R Disease O14773 3EDY A C365Y Disease O14773 3EDY A E343K Disease O14773 3EDY A F481C Disease O14773 3EDY A G284V Disease O14773 3EDY A G389E Disease O14773 3EDY A G473R Disease O14773 3EDY A G482R Disease O14773 3EDY A H175R *Neutral O14773 3EDY A I287N Disease O14773 3EDY A K428N Disease O14773 3EDY A N286S Disease O14773 3EDY A Q100R Neutral O14773 3EDY A Q278P Disease O14773 3EDY A Q422H Disease O14773 3EDY A R100Q *Neutral O14773 3EDY A R127Q Disease O14773 3EDY A R175H Neutral O14773 3EDY A R185C Neutral O14773 3EDY A R206C Disease O14773 3EDY A R206H Disease O14773 3EDY A R447H Disease O14773 3EDY A S153P Disease O14773 3EDY A S475L Disease O14773 3EDY A T353P Disease O14773 3EDY A V277M Disease O14773 3EDY A V385D Disease O14792 1ZRH A K262R Neutral O14792 1ZRH A R262K *Neutral O14815 2P0R A A102V Neutral O14815 2P0R A A239T Neutral O14815 2P0R A K322Q Neutral O14815 2P0R A Q322K *Neutral O14815 2P0R A R277W Neutral O14815 2P0R A T239A *Neutral O14815 2P0R A V102A *Neutral O14815 2P0R A W277R *Neutral O14896 2PI0 B F107Y *Neutral O14896 2PI0 B Y107F Neutral O14920 3BRV C A710T Neutral O14920 3BRV C A736T Neutral O14920 3BRV C F734L Neutral O14920 3BRV C L734F *Neutral O14920 3BRV C T710A *Neutral O14920 3BRV C T736A *Neutral O14936 3C0I A R28L Disease O14958 2VAF A A1047T *Neutral O14958 2VAF A D1288H Disease O14958 2VAF A L1148H Disease O14958 2VAF A M1057V *Neutral O14958 2VAF A R1014Q Disease O14958 2VAF A T1047A Neutral O14958 2VAF A V1057M Neutral O14965 2J4Z B M373V Neutral O14965 2J4Z B V373M *Neutral O15164 2YYN B R126S Neutral O15164 2YYN B S126R *Neutral O15169 1DK8 A L143R Disease O15217 1GUL A L100P Neutral O15217 1GUL A P100L *Neutral O15455 2A0Z A D307Y *Neutral O15455 2A0Z A F412L *Neutral O15455 2A0Z A I284N *Neutral O15455 2A0Z A L412F Neutral O15455 2A0Z A N284I Neutral O15455 2A0Z A P554S Disease O15455 2A0Z A Y307D Neutral O15492 2IK8 D H137R *Neutral O15492 2IK8 D R137H Neutral O15520 1NUN A C106F Disease O15520 1NUN A I156R Disease O15527 1KO9 A A85S Disease O15527 1KO9 A G12E Disease O15527 1KO9 A R46Q Disease O15527 1KO9 A A288V Neutral O15527 1KO9 A D322N Neutral O15527 1KO9 A N322D *Neutral O15527 1KO9 A Q229R *Neutral O15527 1KO9 A R131Q Disease O15527 1KO9 A R154H Disease O15527 1KO9 A R229Q Neutral O15527 1KO9 A S232T Disease O15527 1KO9 A S320T Neutral O15527 1KO9 A T320S *Neutral O15527 1KO9 A V288A *Neutral O15540 1FDQ A M60T *Neutral O15540 1FDQ A T60M Neutral O43159 2ZFU A P329S Neutral O43159 2ZFU A S329P *Neutral O43175 2G76 A R134W Disease O43175 2G76 A V260M Disease O43252 2QJF B F270L *Neutral O43252 2QJF B L270F Neutral O43252 2QJF B L587S *Neutral O43252 2QJF B S587L Neutral O43488 2BP1 A A143T Neutral O43488 2BP1 A C215Y Neutral O43488 2BP1 A E181K Neutral O43488 2BP1 A G199S Neutral O43488 2BP1 A H158Q *Neutral O43488 2BP1 A K181E *Neutral O43488 2BP1 A M136V *Neutral O43488 2BP1 A N256S *Neutral O43488 2BP1 A Q158H Neutral O43488 2BP1 A S199G *Neutral O43488 2BP1 A S256N Neutral O43488 2BP1 A T143A *Neutral O43488 2BP1 A V136M Neutral O43488 2BP1 A Y215C *Neutral O43570 1ZNC A L211V *Neutral O43570 1ZNC A V211L Neutral O60260 1IYF A A46P Disease O60260 1IYF A P37L Disease O60260 1IYF A R33Q Disease O60260 1IYF A R42P Disease O60260 1IYF A V15M Disease O60671 3G65 B A33G Neutral O60671 3G65 B G33A *Neutral O60671 3G65 B H39Q Neutral O60671 3G65 B Q39H *Neutral O60671 3G65 B D114G *Neutral O60671 3G65 B G114D Neutral O60671 3G65 B S104T *Neutral O60671 3G65 B T104S Neutral O60678 2FYT A C487S *Neutral O60678 2FYT A L457V Neutral O60678 2FYT A N525S Neutral O60678 2FYT A S487C Neutral O60678 2FYT A S525N *Neutral O60678 2FYT A V457L *Neutral O60729 1OHC A I302T Neutral O60729 1OHC A T302I *Neutral O60759 2Z17 A E24Q *Neutral O60759 2Z17 A Q24E Neutral O60880 1D4T A H8D Disease O60880 1D4T A Y7C Disease O60880 1D4T A C42W Disease O60880 1D4T A D33Y Disease O60880 1D4T A F87S Disease O60880 1D4T A G16D Disease O60880 1D4T A G27S Disease O60880 1D4T A G49V Disease O60880 1D4T A I84T Disease O60880 1D4T A L31P Disease O60880 1D4T A Q99P Disease O60880 1D4T A R32T Disease O60880 1D4T A R55L Disease O60880 1D4T A S28R Disease O60880 1D4T A T53I Disease O60880 1D4T A T68I Disease O60880 1D4T A Y54C Disease O60880 1D4T A P101L Disease O60880 1D4T A V102G Disease O60882 2JSD A D139N Neutral O60882 2JSD A I169L Neutral O60882 2JSD A L169I *Neutral O60882 2JSD A N139D *Neutral O60885 2OUO A A371G Neutral O60885 2OUO A G371A *Neutral O60921 3GGR B D221E Neutral O60921 3GGR B E221D *Neutral O60921 3GGR B G126S *Neutral O60921 3GGR B K147Q *Neutral O60921 3GGR B Q147K Neutral O60921 3GGR B S126G Neutral O75015 1E4J A I85V Neutral O75015 1E4J A N44S *Neutral O75015 1E4J A S44N Neutral O75015 1E4J A V85I *Neutral O75351 2JQH A I61M Neutral O75351 2JQH A M61I *Neutral O75398 2JW6 A Q542H Disease O75398 2JW6 A R530L Disease O75398 2JW6 A T526N Disease O75594 1YCK A G13V *Neutral O75594 1YCK A V13G Neutral O75695 3BH7 B C67Y Disease O75695 3BH7 B C86Y Disease O75695 3BH7 B P95L Disease O75695 3BH7 B C108G Disease O75695 3BH7 B D338Y Neutral O75695 3BH7 B E138G Disease O75695 3BH7 B K144R Neutral O75695 3BH7 B L188P Disease O75695 3BH7 B L253R Disease O75695 3BH7 B R118C Disease O75695 3BH7 B R118H Disease O75695 3BH7 B R118L Disease O75695 3BH7 B R144K *Neutral O75695 3BH7 B R282W Neutral O75695 3BH7 B W282R *Neutral O75695 3BH7 B Y338D *Neutral O75715 2I3Y A L85V Neutral O75715 2I3Y A V85L *Neutral O75828 1WMA A P130S Neutral O75828 1WMA A S130P *Neutral O75828 2HRB A I93V *Neutral O75828 2HRB A L84V Neutral O75828 2HRB A V84L *Neutral O75828 2HRB A V93I Neutral O75828 2HRB A L235M *Neutral O75828 2HRB A M235L Neutral O75828 2HRB A M244V *Neutral O75828 2HRB A P131S Neutral O75828 2HRB A S131P *Neutral O75828 2HRB A V244M Neutral O75874 1T0L A I178V *Neutral O75874 1T0L A R132C Disease O75874 1T0L A R132G Disease O75874 1T0L A R132H Disease O75874 1T0L A R132L Disease O75874 1T0L A R132S Disease O75874 1T0L A V178I Neutral O75880 2GGT A P174L Disease O76027 1AII A F292S Neutral O76027 1AII A S292F *Neutral O76036 1OLL A K58Q Neutral O76036 1OLL A Q58K *Neutral O94813 2V70 A P636S *Neutral O94813 2V70 A S636P Neutral O95150 2RE9 A F39L Neutral O95150 2RE9 A L39F *Neutral O95363 3CMQ A C21S *Neutral O95363 3CMQ A S21C Neutral O95363 3CMQ A N244S Neutral O95363 3CMQ A S244N *Neutral O95628 1E4U A A7G Neutral O95628 1E4U A G7A *Neutral O95843 1Y1A A S44T Neutral O95843 1Y1A A T44S *Neutral O95843 2GGZ A I71V *Neutral O95843 2GGZ A M84V Neutral O95843 2GGZ A V71I Neutral O95843 2GGZ A V84M *Neutral O95843 2GGZ A A118V Neutral O95843 2GGZ A M158V Neutral O95843 2GGZ A V118A *Neutral O95843 2GGZ A V158M *Neutral O95944 1HKF A M57V Neutral O95944 1HKF A V57M *Neutral O96009 1LYA B G218R Neutral O96009 1LYA B R218G *Neutral O96017 1GXC A G167R Disease O96017 1GXC A I157T Neutral O96017 1GXC A R145P Disease O96017 1GXC A R145W Disease O96017 1GXC A R180C Disease O96017 1GXC A R180H Disease O96017 1GXC A R181C Disease O96017 1GXC A R181H Disease O96017 1GXC A T157I *Neutral P00325 1U3U A K56N *Neutral P00325 1U3U A N56K Neutral P00338 1I10 A E221K *Neutral P00338 1I10 A K221E Neutral P00338 1I10 A R160S *Neutral P00338 1I10 A S160R Neutral P00367 1L1F A E296A Disease P00367 1L1F A G446D Disease P00367 1L1F A G446S Disease P00367 1L1F A H454Y Disease P00367 1L1F A R221C Disease P00367 1L1F A R265K Disease P00367 1L1F A R265T Disease P00367 1L1F A R269C Disease P00367 1L1F A R269H Disease P00367 1L1F A S217C Disease P00367 1L1F A S445L Disease P00367 1L1F A S448P Disease P00367 1L1F A Y266C Disease P00387 1UMK A L72P Disease P00387 1UMK A P65S *Neutral P00387 1UMK A R57Q Disease P00387 1UMK A S65P Neutral P00387 1UMK A A178V Disease P00387 1UMK A C203R Disease P00387 1UMK A C203Y Disease P00387 1UMK A G291D Disease P00387 1UMK A L148P Disease P00387 1UMK A S116T *Neutral P00387 1UMK A S127P Disease P00387 1UMK A T116S Neutral P00387 1UMK A V105M Disease P00390 3DK9 A C109R *Neutral P00390 3DK9 A D253E *Neutral P00390 3DK9 A E253D Neutral P00390 3DK9 A G188R Neutral P00390 3DK9 A G188S Neutral P00390 3DK9 A R109C Neutral P00390 3DK9 A R188G *Neutral P00390 3DK9 A S188G *Neutral P00439 1J8U A A246D Disease P00439 1J8U A A259T Disease P00439 1J8U A A259V Disease P00439 1J8U A A300S Disease P00439 1J8U A A300V Disease P00439 1J8U A A309D Disease P00439 1J8U A A309V Disease P00439 1J8U A A322G Disease P00439 1J8U A A322T Disease P00439 1J8U A A342T Disease P00439 1J8U A A345S Disease P00439 1J8U A A345T Disease P00439 1J8U A A395G Disease P00439 1J8U A A395P Disease P00439 1J8U A A403V Disease P00439 1J8U A C217G Disease P00439 1J8U A C265G Disease P00439 1J8U A C334S Disease P00439 1J8U A C357G Disease P00439 1J8U A D129Y Disease P00439 1J8U A D143G Disease P00439 1J8U A D145V Disease P00439 1J8U A D151H Disease P00439 1J8U A D222V Disease P00439 1J8U A D282N Disease P00439 1J8U A D338Y Disease P00439 1J8U A D394A Disease P00439 1J8U A D394H Disease P00439 1J8U A D415N Disease P00439 1J8U A E178G Disease P00439 1J8U A E183Q Disease P00439 1J8U A E205A Disease P00439 1J8U A E221G Disease P00439 1J8U A E274K *Neutral P00439 1J8U A E280K Disease P00439 1J8U A E330D Disease P00439 1J8U A E390G Disease P00439 1J8U A F161S Disease P00439 1J8U A F233L Disease P00439 1J8U A F240S Disease P00439 1J8U A F263L Disease P00439 1J8U A F299C Disease P00439 1J8U A F331L Disease P00439 1J8U A F410S Disease P00439 1J8U A G148S Disease P00439 1J8U A G171A Disease P00439 1J8U A G171R Disease P00439 1J8U A G218V Disease P00439 1J8U A G239S Disease P00439 1J8U A G247V Disease P00439 1J8U A G257C Disease P00439 1J8U A G337V Disease P00439 1J8U A G344R Disease P00439 1J8U A G344V Disease P00439 1J8U A H146Y Disease P00439 1J8U A H170D Disease P00439 1J8U A H170R Disease P00439 1J8U A H201R Disease P00439 1J8U A H201Y Disease P00439 1J8U A H264L Disease P00439 1J8U A H271Y Disease P00439 1J8U A I164T Disease P00439 1J8U A I174T Disease P00439 1J8U A I174V Disease P00439 1J8U A I224M Disease P00439 1J8U A I269L Disease P00439 1J8U A I283F Disease P00439 1J8U A I283N Disease P00439 1J8U A I306V Disease P00439 1J8U A I318T Disease P00439 1J8U A K274E Neutral P00439 1J8U A K341R Disease P00439 1J8U A K341T Disease P00439 1J8U A L194P Disease P00439 1J8U A L212P Disease P00439 1J8U A L213P Disease P00439 1J8U A L242F Disease P00439 1J8U A L248P Disease P00439 1J8U A L249F Disease P00439 1J8U A L255S Disease P00439 1J8U A L255V Disease P00439 1J8U A L311P Disease P00439 1J8U A L333F Disease P00439 1J8U A L347F Disease P00439 1J8U A L348V Disease P00439 1J8U A M276I Disease P00439 1J8U A M276V Disease P00439 1J8U A N167I Disease P00439 1J8U A N167S Disease P00439 1J8U A N207D Disease P00439 1J8U A N207S Disease P00439 1J8U A P173T Disease P00439 1J8U A P175A Disease P00439 1J8U A P211T Disease P00439 1J8U A P225R Disease P00439 1J8U A P225T Disease P00439 1J8U A P244L Disease P00439 1J8U A P281L Disease P00439 1J8U A P314H Disease P00439 1J8U A P362T Disease P00439 1J8U A P366H Disease P00439 1J8U A P407S Disease P00439 1J8U A Q160P Disease P00439 1J8U A Q304R Disease P00439 1J8U A R155P Disease P00439 1J8U A R157N Disease P00439 1J8U A R158Q Disease P00439 1J8U A R158W Disease P00439 1J8U A R169H Disease P00439 1J8U A R176L Disease P00439 1J8U A R176P Disease P00439 1J8U A R241C Disease P00439 1J8U A R241H Disease P00439 1J8U A R241L Disease P00439 1J8U A R243Q Disease P00439 1J8U A R252G Disease P00439 1J8U A R252Q Disease P00439 1J8U A R252W Disease P00439 1J8U A R261P Disease P00439 1J8U A R261Q Disease P00439 1J8U A R270K Disease P00439 1J8U A R270S Disease P00439 1J8U A R297C Disease P00439 1J8U A R297H Disease P00439 1J8U A R408Q Disease P00439 1J8U A R408W Disease P00439 1J8U A R413P Disease P00439 1J8U A R413S Disease P00439 1J8U A S231F Disease P00439 1J8U A S231P Disease P00439 1J8U A S273F Disease P00439 1J8U A S303P Disease P00439 1J8U A S310F Disease P00439 1J8U A S349L Disease P00439 1J8U A S349P Disease P00439 1J8U A S350T Disease P00439 1J8U A T124I Disease P00439 1J8U A T238P Disease P00439 1J8U A T278A Disease P00439 1J8U A T278N Disease P00439 1J8U A T372S Disease P00439 1J8U A T380M Disease P00439 1J8U A T418P Disease P00439 1J8U A V177L Disease P00439 1J8U A V190A Disease P00439 1J8U A V230I Disease P00439 1J8U A V245A Disease P00439 1J8U A V245E Disease P00439 1J8U A V245L Disease P00439 1J8U A V388L Disease P00439 1J8U A V388M Disease P00439 1J8U A Y154N Disease P00439 1J8U A Y204C Disease P00439 1J8U A Y206D Disease P00439 1J8U A Y277C Disease P00439 1J8U A Y277D Disease P00439 1J8U A Y325C Disease P00439 1J8U A Y343C Disease P00439 1J8U A Y377C Disease P00439 1J8U A Y386C Disease P00439 1J8U A Y387H Disease P00439 1J8U A Y414C Disease P00441 2C9V A A4S Disease P00441 2C9V A A4T Disease P00441 2C9V A A4V Disease P00441 2C9V A C6F Disease P00441 2C9V A L8Q Disease P00441 2C9V A L8V Disease P00441 2C9V A V7E Disease P00441 2C9V A A89T Disease P00441 2C9V A A89V Disease P00441 2C9V A D76Y Disease P00441 2C9V A D90A Disease P00441 2C9V A D90V Disease P00441 2C9V A E21G Disease P00441 2C9V A E21K Disease P00441 2C9V A E49K Disease P00441 2C9V A F20C Disease P00441 2C9V A F45C Disease P00441 2C9V A G12R Disease P00441 2C9V A G16S Disease P00441 2C9V A G37R Disease P00441 2C9V A G41D Disease P00441 2C9V A G41S Disease P00441 2C9V A G72S Disease P00441 2C9V A G85R Disease P00441 2C9V A G93A Disease P00441 2C9V A G93C Disease P00441 2C9V A G93D Disease P00441 2C9V A G93R Disease P00441 2C9V A G93V Disease P00441 2C9V A H43R Disease P00441 2C9V A H46R Disease P00441 2C9V A H48Q Disease P00441 2C9V A H48R Disease P00441 2C9V A H80A Disease P00441 2C9V A L38R Disease P00441 2C9V A L38V Disease P00441 2C9V A L67R Disease P00441 2C9V A L84F Disease P00441 2C9V A L84V Disease P00441 2C9V A N65S Disease P00441 2C9V A N86S Disease P00441 2C9V A Q22L Disease P00441 2C9V A T54R Disease P00441 2C9V A V14G Disease P00441 2C9V A V14M Disease P00441 2C9V A V87A Disease P00441 2C9V A V97M Disease P00441 2C9V A A145T Disease P00441 2C9V A C146R Disease P00441 2C9V A D101G Disease P00441 2C9V A D101N Disease P00441 2C9V A D124G Disease P00441 2C9V A D124V Disease P00441 2C9V A D125H Disease P00441 2C9V A E100G Disease P00441 2C9V A E100K Disease P00441 2C9V A G108V Disease P00441 2C9V A G114A Disease P00441 2C9V A G147R Disease P00441 2C9V A I104F Disease P00441 2C9V A I112M Disease P00441 2C9V A I112T Disease P00441 2C9V A I113T Disease P00441 2C9V A I149T Disease P00441 2C9V A I151T Disease P00441 2C9V A L106V Disease P00441 2C9V A L126S Disease P00441 2C9V A L144F Disease P00441 2C9V A L144S Disease P00441 2C9V A N139K Disease P00441 2C9V A R115G Disease P00441 2C9V A S105L Disease P00441 2C9V A S134N Disease P00441 2C9V A V118L Disease P00441 2C9V A V148G Disease P00441 2C9V A V148I Disease P00492 1BZY A G6D Disease P00492 1BZY A V7G Disease P00492 1BZY A A49P Disease P00492 1BZY A A49V Disease P00492 1BZY A D19V Disease P00492 1BZY A D79V Disease P00492 1BZY A F73L Disease P00492 1BZY A G15D Disease P00492 1BZY A G15S Disease P00492 1BZY A G57R Disease P00492 1BZY A G69E Disease P00492 1BZY A G70R Disease P00492 1BZY A I41F Disease P00492 1BZY A I41T Disease P00492 1BZY A L40P Disease P00492 1BZY A L77V Disease P00492 1BZY A M53L Disease P00492 1BZY A M56T Disease P00492 1BZY A R44K Disease P00492 1BZY A R47H Disease P00492 1BZY A R50G Disease P00492 1BZY A R50P Disease P00492 1BZY A V52A Disease P00492 1BZY A V52M Disease P00492 1BZY A A160S Disease P00492 1BZY A C205Y Disease P00492 1BZY A D134G Disease P00492 1BZY A D176V Disease P00492 1BZY A D176Y Disease P00492 1BZY A D193E Disease P00492 1BZY A D193N Disease P00492 1BZY A D200G Disease P00492 1BZY A D200N Disease P00492 1BZY A D200Y Disease P00492 1BZY A F198V Disease P00492 1BZY A H203D Disease P00492 1BZY A H203R Disease P00492 1BZY A I131M Disease P00492 1BZY A I131T Disease P00492 1BZY A I182T Disease P00492 1BZY A L130S Disease P00492 1BZY A M142K Disease P00492 1BZY A P175L Disease P00492 1BZY A S103R Disease P00492 1BZY A S109L Disease P00492 1BZY A S161R Disease P00492 1BZY A T167I Disease P00492 1BZY A V129D Disease P00492 1BZY A Y194C Disease P00519 2HZI A K247R Neutral P00519 2HZI A R247K *Neutral P00533 1MOX B Q74R *Neutral P00533 1MOX B R74Q Neutral P00533 1MOX B K497R *Neutral P00533 1MOX B P242R Neutral P00533 1MOX B R242P *Neutral P00533 1MOX B R497K Neutral P00533 1Z9I A I6V *Neutral P00533 1Z9I A V6I Neutral P00533 1Z9I A E41A Disease P00533 1Z9I A E41K Disease P00533 1Z9I A G51A Disease P00533 1Z9I A G51C Disease P00533 1Z9I A G51D Disease P00533 1Z9I A G51S Disease P00709 1HML A I27V Neutral P00709 1HML A V27I *Neutral P00734 1EB1 H P37T Neutral P00734 1EB1 H T37P *Neutral P00740 1CFH A E7A Disease P00740 1CFH A E8G Disease P00740 1CFH A F9C Disease P00740 1CFH A L6S Disease P00740 1CFH A N2I Disease P00740 1CFH A S3P Disease P00740 1CFH A D47G Disease P00740 1CFH A E20V Disease P00740 1CFH A E21K Disease P00740 1CFH A E27K Disease P00740 1CFH A E27V Disease P00740 1CFH A E33D Disease P00740 1CFH A F25S Disease P00740 1CFH A G12A Disease P00740 1CFH A G12R Disease P00740 1CFH A R29Q Disease P00740 1CFH A T38R Disease P00740 1CFH A Y45C Disease P00740 1RFN A A55T Disease P00740 1RFN A A68T Disease P00740 1RFN A C42S Disease P00740 1RFN A C42Y Disease P00740 1RFN A C58W Disease P00740 1RFN A E80V Disease P00740 1RFN A G43E Disease P00740 1RFN A G43R Disease P00740 1RFN A H91R Disease P00740 1RFN A N72D Disease P00740 1RFN A N95S Disease P00740 1RFN A Q30H Disease P00740 1RFN A Q30K Disease P00740 1RFN A R83G Disease P00740 1RFN A R83Q Disease P00740 1RFN A V16D Disease P00740 1RFN A V16F Disease P00740 1RFN A V17F Disease P00740 1RFN A V17L Disease P00740 1RFN A A152D Disease P00740 1RFN A A183P Disease P00740 1RFN A A221V Disease P00740 1RFN A C168Y Disease P00740 1RFN A C182F Disease P00740 1RFN A C182S Disease P00740 1RFN A C191R Disease P00740 1RFN A C191S Disease P00740 1RFN A C220Y Disease P00740 1RFN A D194H Disease P00740 1RFN A E217A Disease P00740 1RFN A E217K Disease P00740 1RFN A F181I Disease P00740 1RFN A F181L Disease P00740 1RFN A F208V Disease P00740 1RFN A G136D Disease P00740 1RFN A G142E Disease P00740 1RFN A G142R Disease P00740 1RFN A G149W Disease P00740 1RFN A G196E Disease P00740 1RFN A G197R Disease P00740 1RFN A G216S Disease P00740 1RFN A G216V Disease P00740 1RFN A G226E Disease P00740 1RFN A G226R Disease P00740 1RFN A I103F Disease P00740 1RFN A I176F Disease P00740 1RFN A I227T Disease P00740 1RFN A I238T Disease P00740 1RFN A K148E Disease P00740 1RFN A K173E Disease P00740 1RFN A L105R Disease P00740 1RFN A L108Q Disease P00740 1RFN A L169F Disease P00740 1RFN A L169I Disease P00740 1RFN A M180K Disease P00740 1RFN A P120H Disease P00740 1RFN A P120T Disease P00740 1RFN A P198T Disease P00740 1RFN A R165G Disease P00740 1RFN A R165Q Disease P00740 1RFN A R233Q Disease P00740 1RFN A R233W Disease P00740 1RFN A S195G Disease P00740 1RFN A S195I Disease P00740 1RFN A S214T Disease P00740 1RFN A T129K Disease P00740 1RFN A T129M Disease P00740 1RFN A T210P Disease P00740 1RFN A V203E Disease P00740 1RFN A W141C Disease P00740 1RFN A W215G Disease P00740 1RFN A W215R Disease P00740 1RFN A W237R Disease P00740 1RFN A Y234C Disease P00740 1RFN A I129BL Disease P00740 1RFN A R188AT Disease P00742 1RFN A P245T *Neutral P00742 1RFN A T245P Neutral P00746 1BIO A C201R Disease P00746 1BIO A V200G Disease P00747 1CEA A H31Q Neutral P00747 1CEA A K32R *Neutral P00747 1CEA A Q31H *Neutral P00747 1CEA A R32K Neutral P00747 1KRN A R97W Neutral P00747 1KRN A W97R *Neutral P00747 1KRN A I142K *Neutral P00747 1KRN A K142I Neutral P00747 2DOH X H242R *Neutral P00747 2DOH X R216H Disease P00747 2DOH X R242H Neutral P00749 2FD6 A L121P *Neutral P00749 2FD6 A P121L Neutral P00797 2IKO A D33N Disease P00797 2IKO A K89Q *Neutral P00797 2IKO A Q89K Neutral P00797 2IKO A G146R Neutral P00797 2IKO A R146G *Neutral P00797 2IKO A R159K Disease P00813 1M7M A D8N Neutral P00813 1M7M A N8D *Neutral P00813 1M7M A A83D Disease P00813 1M7M A G20R Disease P00813 1M7M A G74C Disease P00813 1M7M A H15D Disease P00813 1M7M A K80R Neutral P00813 1M7M A R76W Disease P00813 1M7M A R80K *Neutral P00813 1M7M A A179D Disease P00813 1M7M A A215T Disease P00813 1M7M A A329V Disease P00813 1M7M A G140E Disease P00813 1M7M A G216R Disease P00813 1M7M A L107P Disease P00813 1M7M A L152M Disease P00813 1M7M A L304R Disease P00813 1M7M A P274L Disease P00813 1M7M A P297Q Disease P00813 1M7M A Q199P Disease P00813 1M7M A R101L Disease P00813 1M7M A R101Q Disease P00813 1M7M A R101W Disease P00813 1M7M A R142Q Disease P00813 1M7M A R149Q Disease P00813 1M7M A R149W Disease P00813 1M7M A R156C Disease P00813 1M7M A R156H Disease P00813 1M7M A R211C Disease P00813 1M7M A R211H Disease P00813 1M7M A S291L Disease P00813 1M7M A T233I Disease P00813 1M7M A V129M Disease P00813 1M7M A V177M Disease P00915 2FOY B A142V Neutral P00915 2FOY B V142A *Neutral P00918 1LUG A H94Y Disease P00918 1LUG A Q92P Disease P00918 1LUG A D252N *Neutral P00918 1LUG A G144R Disease P00918 1LUG A H107Y Disease P00918 1LUG A N252D Neutral P01008 1LJ5 A H186R *Neutral P01008 1LJ5 A N232T *Neutral P01008 1LJ5 A R186H Neutral P01008 1LJ5 A T232N Neutral P01008 1QLP A D376E *Neutral P01008 1QLP A E264V Neutral P01008 1QLP A E376D Neutral P01008 1QLP A G115S Neutral P01008 1QLP A S115G *Neutral P01008 1QLP A V264E *Neutral P01008 3DY0 A A36V Neutral P01008 3DY0 A G75V Neutral P01008 3DY0 A N45S Neutral P01008 3DY0 A S45N *Neutral P01008 3DY0 A V36A *Neutral P01008 3DY0 A V75G *Neutral P01008 3DY0 A G198R Neutral P01008 3DY0 A R198G *Neutral P01008 3F1S A G250S Neutral P01008 3F1S A L137Q Neutral P01008 3F1S A P363Q *Neutral P01008 3F1S A Q137L *Neutral P01008 3F1S A Q363P Neutral P01008 3F1S A Q363R Neutral P01008 3F1S A R363Q *Neutral P01008 3F1S A S140T *Neutral P01008 3F1S A S250G *Neutral P01008 3F1S A T140S Neutral P01009 1QLP A A213V *Neutral P01009 1QLP A A336T Neutral P01009 1QLP A H101R *Neutral P01009 1QLP A R101H Neutral P01009 1QLP A T336A *Neutral P01009 1QLP A V213A Neutral P01011 2ACH A L55P Disease P01011 2ACH A A144G Neutral P01011 2ACH A G144A *Neutral P01011 2ACH A K243R Neutral P01011 2ACH A P228A Disease P01011 2ACH A R243K *Neutral P01024 3G6J A G80R *Neutral P01024 3G6J A R80G Neutral P01024 3G6J A D527N Disease P01024 3G6J A L292P *Neutral P01024 3G6J A P292L Neutral P01034 1R4C A L68Q Disease P01040 1NB5 I M123T *Neutral P01040 1NB5 I T123M Neutral P01112 1CTQ A E63K Disease P01112 1CTQ A G12A Disease P01112 1CTQ A G12C Disease P01112 1CTQ A G12E Disease P01112 1CTQ A G12S Disease P01112 1CTQ A G12V Disease P01112 1CTQ A G13C Disease P01112 1CTQ A G13D Disease P01112 1CTQ A Q22K Disease P01112 1CTQ A Q61L Disease P01112 1CTQ A T58I Disease P01112 1CTQ A A146T Disease P01112 1CTQ A A146V Disease P01112 1CTQ A K117R Disease P01130 1HJ7 A A370T Neutral P01130 1HJ7 A C308Y Disease P01130 1HJ7 A C317S Disease P01130 1HJ7 A C347R Disease P01130 1HJ7 A C358Y Disease P01130 1HJ7 A D321N Disease P01130 1HJ7 A D335Y Disease P01130 1HJ7 A H306Y Disease P01130 1HJ7 A Q345R Disease P01130 1HJ7 A R329P Disease P01130 1HJ7 A T370A *Neutral P01130 1LDL A A29S Disease P01130 1LDL A C25S Disease P01130 1LDL A S35P Disease P01130 1LDR A C26Y Disease P01130 1LDR A C32G Disease P01130 1LDR A D27N Disease P01130 1LDR A Q29E Disease P01130 1LDR A R15C Disease P01130 1LRX B A399D Disease P01130 1LRX B D482H Disease P01130 1LRX B F403L Disease P01130 1LRX B I423T Disease P01130 1LRX B L401V Disease P01130 1LRX B L414R Disease P01130 1LRX B L432V Disease P01130 1LRX B L568V Disease P01130 1LRX B N564H Disease P01130 1LRX B P608S Disease P01130 1LRX B P649L Disease P01130 1LRX B R416Q Disease P01130 1LRX B R416W Disease P01130 1LRX B R633C Disease P01130 1LRX B W483R Disease P01133 1NQL B D11E Neutral P01133 1NQL B E11D *Neutral P01225 1XWD B C51G Disease P01229 1M92 A A18T Neutral P01229 1M92 A Q74R Disease P01229 1M92 A T18A *Neutral P01233 1HCN B K2R Neutral P01233 1HCN B R2K *Neutral P01233 1HCN B R8W Neutral P01233 1HCN B W8R *Neutral P01374 1TNR A P91T *Neutral P01374 1TNR A T91P Neutral P01583 1ITA A D13N *Neutral P01583 1ITA A D26N Neutral P01583 1ITA A D64H Neutral P01583 1ITA A H64D *Neutral P01583 1ITA A N13D Neutral P01583 1ITA A N26D *Neutral P01730 1WIO A F202S Neutral P01730 1WIO A R240W Neutral P01730 1WIO A S202F *Neutral P01730 1WIO A W240R *Neutral P01730 2NY1 B E1166K *Neutral P01730 2NY1 B K1166E Neutral P01732 1CD8 A G90S Disease P01854 1FP5 A L478W *Neutral P01854 1FP5 A W478L Neutral P01876 1OW0 A D295E *Neutral P01876 1OW0 A E295D Neutral P01891 1HSB A D74H Neutral P01891 1HSB A D77N Neutral P01891 1HSB A G65R *Neutral P01891 1HSB A H74D *Neutral P01891 1HSB A I73T *Neutral P01891 1HSB A N77D *Neutral P01891 1HSB A R65G Neutral P01891 1HSB A T73I Neutral P01891 1HSB A D116H Neutral P01891 1HSB A E114R *Neutral P01891 1HSB A H114R *Neutral P01891 1HSB A H116D *Neutral P01891 1HSB A H151L Neutral P01891 1HSB A L151H *Neutral P01891 1HSB A L156W *Neutral P01891 1HSB A Q156W *Neutral P01891 1HSB A R114E Neutral P01891 1HSB A R114H Neutral P01891 1HSB A W156L Neutral P01891 1HSB A W156Q Neutral P01892 3D25 A A41G Neutral P01892 3D25 A D74H *Neutral P01892 3D25 A F99Y *Neutral P01892 3D25 A G41A *Neutral P01892 3D25 A H70Q Neutral P01892 3D25 A H74D Neutral P01892 3D25 A L95V *Neutral P01892 3D25 A M97R *Neutral P01892 3D25 A Q70H *Neutral P01892 3D25 A R97M Neutral P01892 3D25 A V95L Neutral P01892 3D25 A Y99F Neutral P01892 3D25 A A149T Neutral P01892 3D25 A A236E Neutral P01892 3D25 A D166E *Neutral P01892 3D25 A E152V *Neutral P01892 3D25 A E166D Neutral P01892 3D25 A E236A *Neutral P01892 3D25 A G107W *Neutral P01892 3D25 A K138M *Neutral P01892 3D25 A M138K Neutral P01892 3D25 A T149A *Neutral P01892 3D25 A V152E Neutral P01892 3D25 A W107G Neutral P01909 1S9V A E31Q *Neutral P01909 1S9V A F22Y *Neutral P01909 1S9V A K38R *Neutral P01909 1S9V A L66V Neutral P01909 1S9V A Q31E Neutral P01909 1S9V A R38K Neutral P01909 1S9V A R52S Neutral P01909 1S9V A S52R *Neutral P01909 1S9V A V66L *Neutral P01909 1S9V A Y22F Neutral P01909 1S9V A H126Q Neutral P01909 1S9V A Q126H *Neutral P01909 1UVQ A D2G Neutral P01909 1UVQ A G2D *Neutral P01909 1UVQ A C11Y Neutral P01909 1UVQ A E34Q *Neutral P01909 1UVQ A F18S Neutral P01909 1UVQ A F25Y *Neutral P01909 1UVQ A K41R *Neutral P01909 1UVQ A Q34E Neutral P01909 1UVQ A Q47R *Neutral P01909 1UVQ A R41K Neutral P01909 1UVQ A R47Q Neutral P01909 1UVQ A S18F *Neutral P01909 1UVQ A S26T *Neutral P01909 1UVQ A S80Y *Neutral P01909 1UVQ A T26S Neutral P01909 1UVQ A Y11C *Neutral P01909 1UVQ A Y25F Neutral P01909 1UVQ A Y80S Neutral P01909 1UVQ A H129Q *Neutral P01909 1UVQ A I107T *Neutral P01909 1UVQ A Q129H Neutral P01909 1UVQ A T107I Neutral P01912 1A6A B N77T Neutral P01912 1A6A B T77N *Neutral P01912 1A6A B A140T *Neutral P01912 1A6A B T140A Neutral P01920 1JK8 B D162E *Neutral P01920 1JK8 B E162D Neutral P01920 1JK8 B I116V *Neutral P01920 1JK8 B L165P *Neutral P01920 1JK8 B P165L Neutral P01920 1JK8 B V116I Neutral P01920 1NBN B A133D *Neutral P01920 1NBN B A138T Neutral P01920 1NBN B D133A Neutral P01920 1NBN B D133G Neutral P01920 1NBN B D160E *Neutral P01920 1NBN B E160D Neutral P01920 1NBN B G133D *Neutral P01920 1NBN B I114V *Neutral P01920 1NBN B I183T *Neutral P01920 1NBN B L163P *Neutral P01920 1NBN B P163L Neutral P01920 1NBN B T138A *Neutral P01920 1NBN B T183I Neutral P01920 1NBN B V114I Neutral P02042 1IRD A D59G *Neutral P02042 1IRD A F10V *Neutral P02042 1IRD A F91L *Neutral P02042 1IRD A G59D Neutral P02042 1IRD A L91F Neutral P02042 1IRD A V10F Neutral P02042 1IRD B A213D Neutral P02042 1IRD B D213A *Neutral P02042 1IRD B E206V Neutral P02042 1IRD B E207G Neutral P02042 1IRD B E208K *Neutral P02042 1IRD B E217K *Neutral P02042 1IRD B G207E *Neutral P02042 1IRD B G215W *Neutral P02042 1IRD B G267V *Neutral P02042 1IRD B H202Q Neutral P02042 1IRD B K208E Neutral P02042 1IRD B K217E Neutral P02042 1IRD B L281V Neutral P02042 1IRD B M218V *Neutral P02042 1IRD B P205R Neutral P02042 1IRD B Q202H *Neutral P02042 1IRD B R205P *Neutral P02042 1IRD B V206E *Neutral P02042 1IRD B V218M Neutral P02042 1IRD B V267G Neutral P02042 1IRD B V281L *Neutral P02042 1IRD B W215G Neutral P02042 1SHR B I4T *Neutral P02042 1SHR B T4I Neutral P02545 1IVT A A529V Disease P02545 1IVT A D446V Disease P02545 1IVT A G465D Disease P02545 1IVT A K486N Disease P02545 1IVT A K542N Disease P02545 1IVT A L530P Disease P02545 1IVT A N456I Disease P02545 1IVT A R435C Disease P02545 1IVT A R453W Disease P02545 1IVT A R471C Disease P02545 1IVT A R482L Disease P02545 1IVT A R482Q Disease P02545 1IVT A R482W Disease P02545 1IVT A R527C Disease P02545 1IVT A R527H Disease P02545 1IVT A R527P Disease P02545 1IVT A R541H Disease P02545 1IVT A R541S Disease P02545 1IVT A T528R Disease P02545 1IVT A Y481H Disease P02545 1X8Y A E317K Disease P02545 1X8Y A R349L Disease P02545 1X8Y A R377H Disease P02545 1X8Y A R377L Disease P02549 1OWA A G46V Disease P02549 1OWA A I24S Disease P02549 1OWA A K48R Disease P02549 1OWA A L49F Disease P02549 1OWA A R28C Disease P02549 1OWA A R28H Disease P02549 1OWA A R28L Disease P02549 1OWA A R28S Disease P02549 1OWA A R34W Disease P02549 1OWA A R41W Disease P02549 1OWA A R45S Disease P02549 1OWA A R45T Disease P02549 1OWA A V31A Disease P02549 1OWA A F109S *Neutral P02549 1OWA A G151D Disease P02549 1OWA A S109F Neutral P02647 2A01 A P3R Neutral P02647 2A01 A R3P *Neutral P02647 2A01 A A37T Neutral P02647 2A01 A D89E Neutral P02647 2A01 A E89D *Neutral P02647 2A01 A G26R Disease P02647 2A01 A I68T *Neutral P02647 2A01 A L60R Disease P02647 2A01 A T37A *Neutral P02647 2A01 A T68I Neutral P02647 2A01 A D102H Neutral P02647 2A01 A E139G Neutral P02647 2A01 A E147V Neutral P02647 2A01 A G139E *Neutral P02647 2A01 A H102D *Neutral P02647 2A01 A K107M Neutral P02647 2A01 A M107K *Neutral P02647 2A01 A P160R *Neutral P02647 2A01 A P165R Neutral P02647 2A01 A R160P Neutral P02647 2A01 A R165P *Neutral P02647 2A01 A V147E *Neutral P02649 1BZ4 A A42T *Neutral P02649 1BZ4 A A99T Neutral P02649 1BZ4 A H46Q *Neutral P02649 1BZ4 A K81Q *Neutral P02649 1BZ4 A L28P Neutral P02649 1BZ4 A P28L *Neutral P02649 1BZ4 A P84R Neutral P02649 1BZ4 A Q46H Neutral P02649 1BZ4 A Q81K Neutral P02649 1BZ4 A R25C Disease P02649 1BZ4 A R84P *Neutral P02649 1BZ4 A T42A Neutral P02649 1BZ4 A T99A *Neutral P02649 1BZ4 A A106V Neutral P02649 1BZ4 A A152P Neutral P02649 1BZ4 A C112R Disease P02649 1BZ4 A D127G *Neutral P02649 1BZ4 A G127D Neutral P02649 1BZ4 A K146E Disease P02649 1BZ4 A K146Q Disease P02649 1BZ4 A P152A *Neutral P02649 1BZ4 A Q134R *Neutral P02649 1BZ4 A R134Q Neutral P02649 1BZ4 A R136C Disease P02649 1BZ4 A R136S Disease P02649 1BZ4 A R142C Disease P02649 1BZ4 A R145C Disease P02649 1BZ4 A R145P Disease P02649 1BZ4 A R158C Disease P02649 1BZ4 A V106A *Neutral P02649 2KC3 A E3K Neutral P02649 2KC3 A K3E *Neutral P02649 2KC3 A E13K Disease P02654 1IOJ A S45T *Neutral P02654 1IOJ A T45S Neutral P02655 1I5J A E38K Neutral P02655 1I5J A K19T Neutral P02655 1I5J A K38E *Neutral P02655 1I5J A K55Q Neutral P02655 1I5J A Q55K *Neutral P02655 1I5J A T19K *Neutral P02655 1I5J A W26R Disease P02656 2JQ3 A K58E Disease P02671 3GHG J S47T Neutral P02671 3GHG J T47S *Neutral P02675 1FZC B G400D Disease P02675 1FZC B K448R *Neutral P02675 1FZC B L235P *Neutral P02675 1FZC B L353R Disease P02675 1FZC B P235L Neutral P02675 1FZC B R166C Disease P02675 1FZC B R448K Neutral P02675 1FZC C H114Y *Neutral P02675 1FZC C Y114H Neutral P02675 2FIB A G165R Neutral P02675 2FIB A R165G *Neutral P02675 3GHG B P70S Neutral P02675 3GHG B S70P *Neutral P02675 3GHG B H140N *Neutral P02675 3GHG B N140H Neutral P02675 3GHG I E51G Neutral P02675 3GHG I G51E *Neutral P02679 2FIB A M384V Neutral P02679 2FIB A V384M *Neutral P02730 1HYN Q D72E *Neutral P02730 1HYN Q E56K *Neutral P02730 1HYN Q E68K Neutral P02730 1HYN Q E72D Neutral P02730 1HYN Q E90K Disease P02730 1HYN Q K56E Neutral P02730 1HYN Q K68E *Neutral P02730 1HYN Q L73M Neutral P02730 1HYN Q M73L *Neutral P02730 1HYN Q A285D Disease P02730 1HYN Q G130R Disease P02730 1HYN Q P147S Disease P02730 1HYN Q P327R Disease P02730 1HYN Q R112S Neutral P02730 1HYN Q S112R *Neutral P02743 2W08 A E136G Neutral P02743 2W08 A G136E *Neutral P02743 2W08 A G139S *Neutral P02743 2W08 A S139G Neutral P02751 1FNA A R21S *Neutral P02751 1FNA A S21R Neutral P02751 1FNH A I240V Neutral P02751 1FNH A L163R Disease P02751 1FNH A V240I *Neutral P02751 1FNH A W114R Disease P02753 2APD A L95S *Neutral P02753 2APD A S95L Neutral P02763 3BX6 A Q20R Neutral P02763 3BX6 A R20Q *Neutral P02763 3BX6 A C149R *Neutral P02763 3BX6 A M156V *Neutral P02763 3BX6 A R149C Neutral P02763 3BX6 A V156M Neutral P02766 1F41 A A36P Disease P02766 1F41 A A45D Disease P02766 1F41 A A45S Disease P02766 1F41 A A45T Disease P02766 1F41 A A91S Disease P02766 1F41 A A97G Disease P02766 1F41 A A97S Disease P02766 1F41 A C10R Disease P02766 1F41 A D18E Disease P02766 1F41 A D18G Disease P02766 1F41 A D38A Disease P02766 1F41 A D38V Disease P02766 1F41 A D74H Neutral P02766 1F41 A E42D Disease P02766 1F41 A E42G Disease P02766 1F41 A E54G Disease P02766 1F41 A E54K Disease P02766 1F41 A E61G Disease P02766 1F41 A E61K Disease P02766 1F41 A E89K Disease P02766 1F41 A E89Q Disease P02766 1F41 A F33I Disease P02766 1F41 A F33L Disease P02766 1F41 A F33V Disease P02766 1F41 A F44S Disease P02766 1F41 A F64L Disease P02766 1F41 A G47A Disease P02766 1F41 A G47E Disease P02766 1F41 A G47R Disease P02766 1F41 A G47V Disease P02766 1F41 A G53E Disease P02766 1F41 A H74D *Neutral P02766 1F41 A H90N Neutral P02766 1F41 A I13M *Neutral P02766 1F41 A I68L Disease P02766 1F41 A I73V Disease P02766 1F41 A I84N Disease P02766 1F41 A I84S Disease P02766 1F41 A I84T Disease P02766 1F41 A K35N Disease P02766 1F41 A K70N Disease P02766 1F41 A L12P Disease P02766 1F41 A L55P Disease P02766 1F41 A L55Q Disease P02766 1F41 A L58H Disease P02766 1F41 A L58R Disease P02766 1F41 A M13I Neutral P02766 1F41 A N90H *Neutral P02766 1F41 A P24S Disease P02766 1F41 A R34T Disease P02766 1F41 A S23N Disease P02766 1F41 A S50I Disease P02766 1F41 A S50R Disease P02766 1F41 A S52P Disease P02766 1F41 A S77Y Disease P02766 1F41 A T49A Disease P02766 1F41 A T49I Disease P02766 1F41 A T59K Disease P02766 1F41 A T60A Disease P02766 1F41 A V20I Disease P02766 1F41 A V28M Disease P02766 1F41 A V30A Disease P02766 1F41 A V30G Disease P02766 1F41 A V30L Disease P02766 1F41 A V30M Disease P02766 1F41 A V71A Disease P02766 1F41 A W41L Disease P02766 1F41 A Y69H Disease P02766 1F41 A Y78F Disease P02766 1F41 A A120S Disease P02766 1F41 A C104R *Neutral P02766 1F41 A G101S Neutral P02766 1F41 A H104R *Neutral P02766 1F41 A I107M Disease P02766 1F41 A I107V Disease P02766 1F41 A L111M Disease P02766 1F41 A N124S Disease P02766 1F41 A P102R Neutral P02766 1F41 A R102P *Neutral P02766 1F41 A R104C Neutral P02766 1F41 A R104H Neutral P02766 1F41 A S101G *Neutral P02766 1F41 A T106N Disease P02766 1F41 A V122A Disease P02766 1F41 A V122I Disease P02766 1F41 A Y114C Disease P02766 1F41 A Y114H Disease P02766 1F41 A Y116S Disease P02766 1TTA A G6S Neutral P02766 1TTA A S6G *Neutral P02768 1N5U A E97G Neutral P02768 1N5U A F49Y Neutral P02768 1N5U A G97E *Neutral P02768 1N5U A L66P Disease P02768 1N5U A Y49F *Neutral P02768 1N5U A A191T Neutral P02768 1N5U A A191V Neutral P02768 1N5U A E396K Neutral P02768 1N5U A E466K *Neutral P02768 1N5U A K396E *Neutral P02768 1N5U A K466E Neutral P02768 1N5U A L196Q *Neutral P02768 1N5U A Q196L Neutral P02768 1N5U A R218H Disease P02768 1N5U A R218P Disease P02768 1N5U A T191A *Neutral P02768 1N5U A V191A *Neutral P02774 1KW2 A C445R *Neutral P02774 1KW2 A D432E Neutral P02774 1KW2 A E432D *Neutral P02774 1KW2 A H445R *Neutral P02774 1KW2 A K436T Neutral P02774 1KW2 A R445C Neutral P02774 1KW2 A R445H Neutral P02774 1KW2 A T436K *Neutral P02787 1RYO A A57V Neutral P02787 1RYO A D58N Disease P02787 1RYO A R36S *Neutral P02787 1RYO A S36R Neutral P02787 1RYO A V57A *Neutral P02787 1RYO A D277G Neutral P02787 1RYO A G123S Neutral P02787 1RYO A G277D *Neutral P02787 1RYO A H300R Neutral P02787 1RYO A R300H *Neutral P02787 1RYO A S123G *Neutral P02787 2HAV A A458P Disease P02787 2HAV A C358W *Neutral P02787 2HAV A E652G *Neutral P02787 2HAV A G652E Neutral P02787 2HAV A W358C Neutral P02788 1CB6 A C1403G *Neutral P02788 1CB6 A D1560E *Neutral P02788 1CB6 A E1560D Neutral P02788 1CB6 A G1403C Neutral P02788 1CB6 A I1129T Neutral P02788 1CB6 A T1129I *Neutral P02792 2FFX J A99T Disease P03950 1B1I A C39W Disease P03950 1B1I A E60K *Neutral P03950 1B1I A K17E Disease P03950 1B1I A K17I Disease P03950 1B1I A K40I Disease P03950 1B1I A K60E Neutral P03950 1B1I A Q12L Disease P03950 1B1I A R31K Disease P03950 1B1I A S28N Disease P03950 1B1I A H114R Disease P03950 1B1I A P112L Disease P03950 1B1I A V113I Disease P03951 1XX9 A A56V Disease P03951 1XX9 A F82V Disease P03951 1XX9 A G42V Disease P03951 1XX9 A T32N Disease P03951 1XX9 A E186K Disease P03951 1XX9 A I238S Disease P03951 1XX9 A P161L Disease P03951 1XX9 A S214R Disease P03951 1XX9 A T115I Disease P03951 1XX9 A W203S Disease P03951 1XX9 A Y133H Disease P03951 2J8J A E323K Disease P03951 2J8J A F283L Disease P03951 2J8J A F290I *Neutral P03951 2J8J A I290F Neutral P03951 2J8J A L302P Disease P03951 2J8J A R308C Disease P03951 2J8J A T304I Disease P03952 1XX9 A R27W *Neutral P03952 1XX9 A W27R Neutral P03952 2J8J A C321F Neutral P03952 2J8J A F321C *Neutral P03956 1HFC A D252G Neutral P03956 1HFC A G252D *Neutral P03989 2A83 A A41T Neutral P03989 2A83 A D77N Neutral P03989 2A83 A D77S Neutral P03989 2A83 A N77D *Neutral P03989 2A83 A N80T *Neutral P03989 2A83 A N97S Neutral P03989 2A83 A S77D *Neutral P03989 2A83 A S97N *Neutral P03989 2A83 A T41A *Neutral P03989 2A83 A T80N Neutral P03989 2A83 A D116Y Neutral P03989 2A83 A R131S *Neutral P03989 2A83 A S131R Neutral P03989 2A83 A Y116D *Neutral P03999 1KPN A G79R Disease P03999 1KPN A P264S Disease P03999 1KPN A S214P Disease P04000 1KPX A I65T *Neutral P04000 1KPX A T65I Neutral P04000 1KPX A A174V Neutral P04000 1KPX A A180S *Neutral P04000 1KPX A A298P Neutral P04000 1KPX A C203R Disease P04000 1KPX A F309Y *Neutral P04000 1KPX A I111V Neutral P04000 1KPX A I230T Neutral P04000 1KPX A I274V Neutral P04000 1KPX A L153M Neutral P04000 1KPX A M153L *Neutral P04000 1KPX A P298A *Neutral P04000 1KPX A P307L Disease P04000 1KPX A S116Y Neutral P04000 1KPX A S180A Neutral P04000 1KPX A T230I *Neutral P04000 1KPX A V111I *Neutral P04000 1KPX A V174A *Neutral P04000 1KPX A V274I *Neutral P04000 1KPX A Y116S *Neutral P04000 1KPX A Y309F Neutral P04001 1KPW A C203R Disease P04035 1HW8 C I638V Neutral P04035 1HW8 C V638I *Neutral P04054 3ELO A A-6D *Neutral P04054 3ELO A D-6A Neutral P04054 3ELO A K67N *Neutral P04054 3ELO A N67K Neutral P04054 3ELO A N67T Neutral P04054 3ELO A T67N *Neutral P04070 1AUT C I47T Disease P04070 1AUT C P92L Disease P04070 1AUT C R24Q Disease P04070 1AUT C R24W Disease P04070 1AUT C R75C Disease P04070 1AUT C C220Y Disease P04070 1AUT C D194N Disease P04070 1AUT C G127R Disease P04070 1AUT C G133S Disease P04070 1AUT C G186R Disease P04070 1AUT C G211D Disease P04070 1AUT C G216S Disease P04070 1AUT C P124L Disease P04070 1AUT C P164L Disease P04070 1AUT C T139M Disease P04070 1AUT C T229N Disease P04070 1AUT C V162A Disease P04070 1AUT C W237C Disease P04070 1AUT C Y234H Disease P04070 1AUT C R128CC Disease P04070 1AUT C R128CH Disease P04070 1PCU A A136P Disease P04070 1PCU A P168L Disease P04070 1PCU A R169W Disease P04075 1ALD A E81Q Neutral P04075 1ALD A Q81E *Neutral P04075 1ALD A C338Y Disease P04075 1ALD A D128G Disease P04075 1ALD A E206K Disease P04075 1ALD A G141V Neutral P04075 1ALD A G346S Disease P04075 1ALD A V141G *Neutral P04075 1QO5 A E206Q Neutral P04075 1QO5 A Q206E *Neutral P04075 1QO5 A R133S Neutral P04075 1QO5 A S133R *Neutral P04141 2GMF A I98T *Neutral P04141 2GMF A T98I Neutral P04141 2GMF A I100T Neutral P04141 2GMF A T100I *Neutral P04155 1HI7 A T8I Disease P04155 1HI7 A T8K Disease P04155 1HI7 A A10D Disease P04155 1HI7 A E13K Disease P04155 1HI7 A G31V Disease P04156 1I4M A D178N Disease P04156 1I4M A D202N Disease P04156 1I4M A E196K Disease P04156 1I4M A E200K Disease P04156 1I4M A E211Q Disease P04156 1I4M A E219K Neutral P04156 1I4M A F198S Disease P04156 1I4M A G131V Disease P04156 1I4M A H187R Disease P04156 1I4M A K219E *Neutral P04156 1I4M A M129V Neutral P04156 1I4M A N171S Neutral P04156 1I4M A Q212P Disease P04156 1I4M A Q217R Disease P04156 1I4M A R188T *Neutral P04156 1I4M A R208H Disease P04156 1I4M A S171N *Neutral P04156 1I4M A T188R Neutral P04156 1I4M A V129M *Neutral P04156 1I4M A V180I Disease P04156 1I4M A V203I Disease P04156 1I4M A V210I Disease P04179 1LUV A E42V Neutral P04179 1LUV A G52R Neutral P04179 1LUV A I58T Neutral P04179 1LUV A R52G *Neutral P04179 1LUV A T58I *Neutral P04179 1LUV A V42E *Neutral P04179 1LUV A R132W Neutral P04179 1LUV A W132R *Neutral P04181 2OAT A C93F Disease P04181 2OAT A N54K Disease P04181 2OAT A N89K Disease P04181 2OAT A Q90E Disease P04181 2OAT A Y55H Disease P04181 2OAT A A226V Disease P04181 2OAT A A270P Disease P04181 2OAT A C394R Disease P04181 2OAT A F437L *Neutral P04181 2OAT A G353D Disease P04181 2OAT A G375A Disease P04181 2OAT A H319Y Disease P04181 2OAT A L402P Disease P04181 2OAT A L437F Neutral P04181 2OAT A P241L Disease P04181 2OAT A P417L Disease P04181 2OAT A R154L Disease P04181 2OAT A R180T Disease P04181 2OAT A R250P Disease P04181 2OAT A R271K Disease P04181 2OAT A T267I Disease P04181 2OAT A V332M Disease P04181 2OAT A Y245C Disease P04222 1EFX A A49E Neutral P04222 1EFX A E49A *Neutral P04222 1EFX A G91R Neutral P04222 1EFX A I94T Neutral P04222 1EFX A I95L Neutral P04222 1EFX A K80N *Neutral P04222 1EFX A L95I *Neutral P04222 1EFX A M52V *Neutral P04222 1EFX A N77S *Neutral P04222 1EFX A N80K Neutral P04222 1EFX A R91G *Neutral P04222 1EFX A S77N Neutral P04222 1EFX A T94I *Neutral P04222 1EFX A V52M Neutral P04222 1EFX A D114V Neutral P04222 1EFX A S116Y *Neutral P04222 1EFX A V114D *Neutral P04222 1EFX A Y116S Neutral P04229 1KLU B K4R *Neutral P04229 1KLU B R4K Neutral P04229 1KLU B A71R *Neutral P04229 1KLU B A74E Neutral P04229 1KLU B A85V *Neutral P04229 1KLU B E10Q *Neutral P04229 1KLU B E70Q *Neutral P04229 1KLU B E71R *Neutral P04229 1KLU B E74A *Neutral P04229 1KLU B F47Y *Neutral P04229 1KLU B G45R Neutral P04229 1KLU B G86V Neutral P04229 1KLU B H70Q *Neutral P04229 1KLU B H78Y *Neutral P04229 1KLU B I67L *Neutral P04229 1KLU B L67I Neutral P04229 1KLU B Q10E Neutral P04229 1KLU B Q70E Neutral P04229 1KLU B Q70H Neutral P04229 1KLU B R45G *Neutral P04229 1KLU B R71A Neutral P04229 1KLU B R71E Neutral P04229 1KLU B V85A Neutral P04229 1KLU B V86G *Neutral P04229 1KLU B Y47F Neutral P04229 1KLU B Y78H Neutral P04229 1KLU B I181T *Neutral P04229 1KLU B T181I Neutral P04275 1AUQ A A618T Neutral P04275 1AUQ A A698V Disease P04275 1AUQ A C509R Disease P04275 1AUQ A G561S Disease P04275 1AUQ A H505D Disease P04275 1AUQ A H636R *Neutral P04275 1AUQ A L697V Disease P04275 1AUQ A P503L Disease P04275 1AUQ A R543W Disease P04275 1AUQ A R545C Disease P04275 1AUQ A R578Q Disease P04275 1AUQ A R611C Disease P04275 1AUQ A R611H Disease P04275 1AUQ A R636H Neutral P04275 1AUQ A T618A *Neutral P04275 1AUQ A V551L Disease P04275 1AUQ A V553M Disease P04275 1AUQ A V555L Disease P04275 1AUQ A W550C Disease P04278 1KDK A L156P *Neutral P04278 1KDK A P156L Neutral P04406 1U8F O A22G Neutral P04406 1U8F O G22A *Neutral P04406 1U8F O K251N Neutral P04406 1U8F O N251K *Neutral P04626 1OVC A L19P Disease P04626 1OVC A L32S Neutral P04626 1OVC A S32L *Neutral P04626 1OVC A E178K Disease P04626 1OVC A N121S Disease P04626 2JWA A I54V Neutral P04626 2JWA A I55V Neutral P04626 2JWA A V54I *Neutral P04626 2JWA A V55I *Neutral P04629 2IFG A L93P Disease P04629 2IFG A R85S Neutral P04629 2IFG A S85R *Neutral P04629 2IFG A G260R *Neutral P04629 2IFG A L213P Disease P04629 2IFG A M237T *Neutral P04629 2IFG A R260G Neutral P04629 2IFG A T237M Neutral P04632 1KFU S M924V Neutral P04632 1KFU S V924M *Neutral P04637 1OLG A A360G *Neutral P04637 1OLG A G325V Disease P04637 1OLG A G360A Neutral P04637 1OLG A K321E Disease P04637 1OLG A L344P Disease P04637 1OLG A R337C Disease P04637 1OLG A R337H Disease P04637 2AC0 A V97I Disease P04637 2AC0 A A138P Disease P04637 2AC0 A A138S Disease P04637 2AC0 A A189V Disease P04637 2AC0 A C141Y Disease P04637 2AC0 A C238G Disease P04637 2AC0 A C238S Disease P04637 2AC0 A C238Y Disease P04637 2AC0 A C242Y Disease P04637 2AC0 A C275Y Disease P04637 2AC0 A C277Y Disease P04637 2AC0 A D281G Disease P04637 2AC0 A D281N Disease P04637 2AC0 A D281V Disease P04637 2AC0 A E180K Disease P04637 2AC0 A E258K Disease P04637 2AC0 A E271V Disease P04637 2AC0 A E285Q Disease P04637 2AC0 A E286A Disease P04637 2AC0 A G105C Disease P04637 2AC0 A G154V Disease P04637 2AC0 A G244D Disease P04637 2AC0 A G244V Disease P04637 2AC0 A G245C Disease P04637 2AC0 A G245D Disease P04637 2AC0 A G245S Disease P04637 2AC0 A G245V Disease P04637 2AC0 A H179Y Disease P04637 2AC0 A H193R Disease P04637 2AC0 A H233D Disease P04637 2AC0 A I162N Disease P04637 2AC0 A I251M Disease P04637 2AC0 A K132E Disease P04637 2AC0 A L252P Disease P04637 2AC0 A L257Q Disease P04637 2AC0 A L265P Disease P04637 2AC0 A M133R Disease P04637 2AC0 A M133T Disease P04637 2AC0 A M217V *Neutral P04637 2AC0 A M237I Disease P04637 2AC0 A M246V Disease P04637 2AC0 A N210Y Disease P04637 2AC0 A N235D Disease P04637 2AC0 A N235S Disease P04637 2AC0 A P151S Disease P04637 2AC0 A P151T Disease P04637 2AC0 A P152L Disease P04637 2AC0 A P219S Disease P04637 2AC0 A P278L Disease P04637 2AC0 A P278S Disease P04637 2AC0 A P278T Disease P04637 2AC0 A Q144L Disease P04637 2AC0 A Q167K Disease P04637 2AC0 A R110L Disease P04637 2AC0 A R156H Disease P04637 2AC0 A R158G Disease P04637 2AC0 A R158H Disease P04637 2AC0 A R174G Disease P04637 2AC0 A R175G Disease P04637 2AC0 A R175H Disease P04637 2AC0 A R175L Disease P04637 2AC0 A R181C Disease P04637 2AC0 A R181H Disease P04637 2AC0 A R181L Disease P04637 2AC0 A R181P Disease P04637 2AC0 A R196P Disease P04637 2AC0 A R213P Disease P04637 2AC0 A R213Q Disease P04637 2AC0 A R248Q Disease P04637 2AC0 A R248W Disease P04637 2AC0 A R267Q Disease P04637 2AC0 A R273C Disease P04637 2AC0 A R273G Disease P04637 2AC0 A R273H Disease P04637 2AC0 A R273L Disease P04637 2AC0 A R273S Disease P04637 2AC0 A R280K Disease P04637 2AC0 A R282G Disease P04637 2AC0 A R282Q Disease P04637 2AC0 A R282W Disease P04637 2AC0 A R283C Disease P04637 2AC0 A R283H Disease P04637 2AC0 A R290H Disease P04637 2AC0 A R290L Disease P04637 2AC0 A S106R Disease P04637 2AC0 A S227T Disease P04637 2AC0 A S241F Disease P04637 2AC0 A S241T Disease P04637 2AC0 A T155N Disease P04637 2AC0 A T256I Disease P04637 2AC0 A V172F Disease P04637 2AC0 A V173M Disease P04637 2AC0 A V197E Disease P04637 2AC0 A V197M Disease P04637 2AC0 A V217M Neutral P04637 2AC0 A V272A Disease P04637 2AC0 A V272L Disease P04637 2AC0 A Y126C Disease P04637 2AC0 A Y163C Disease P04637 2AC0 A Y220C Disease P04637 2AC0 A Y220S Disease P04637 2AC0 A Y234C Disease P04637 2AC0 A Y236C Disease P05019 1BQT A A67T Neutral P05019 1BQT A T67A *Neutral P05019 2GF1 A A67T Neutral P05019 2GF1 A T67A *Neutral P05062 1QO5 A I73T Disease P05062 1QO5 A A149P Disease P05062 1QO5 A A174D Disease P05062 1QO5 A A337V Disease P05062 1QO5 A C134R Disease P05062 1QO5 A C177R Disease P05062 1QO5 A I267N Neutral P05062 1QO5 A L228P Disease P05062 1QO5 A L256P Disease P05062 1QO5 A L283P Disease P05062 1QO5 A N267I *Neutral P05062 1QO5 A N334K Disease P05062 1QO5 A P184R Disease P05062 1QO5 A R303Q Disease P05062 1QO5 A R303W Disease P05062 1QO5 A V221F Disease P05067 1AML A D7N Disease P05067 1AML A A21G Disease P05067 1AML A D23N Disease P05067 1AML A E22G Disease P05067 1AML A E22K Disease P05067 1AML A E22Q Disease P05067 1AML A L34V Disease P05067 1IYT A A42T Disease P05067 1IYT A A42V Neutral P05067 1IYT A V42A *Neutral P05067 1RW6 A E482K Neutral P05067 1RW6 A K482E *Neutral P05089 2AEB A I11T Disease P05089 2AEB A G138V Disease P05089 2AEB A G235R Disease P05089 2AEB A S290T *Neutral P05089 2AEB A T290S Neutral P05090 2APD A K158T *Neutral P05090 2APD A T158K Neutral P05091 1O02 A E487K Neutral P05091 1O02 A K487E *Neutral P05093 2C17 A D69V Disease P05093 2C17 A F46C Disease P05093 2C17 A F67V Disease P05093 2C17 A R49W Disease P05093 2C17 A S59P Disease P05093 2C17 A Y17S Disease P05093 2C17 A F370C Disease P05093 2C17 A H326L Disease P05093 2C17 A N130D Disease P05093 2C17 A P295T Disease P05093 2C17 A P381L Disease P05093 2C17 A R300C Disease P05093 2C17 A R300H Disease P05093 2C17 A R311Q Disease P05093 2C17 A R315C Disease P05093 2C17 A R393H Disease P05093 2C17 A R449C Disease P05093 2C17 A R449H Disease P05093 2C17 A W359R Disease P05093 2C17 A Y282D Disease P05106 1M8O B S57P Disease P05106 1TYE B L33P Neutral P05106 1TYE B L40R Neutral P05106 1TYE B P33L *Neutral P05106 1TYE B R40L *Neutral P05106 1TYE B R93W Disease P05106 1TYE B C374Y Disease P05106 1TYE B D119N Disease P05106 1TYE B D119Y Disease P05106 1TYE B D217V Disease P05106 1TYE B H280P Disease P05106 1TYE B I304N Disease P05106 1TYE B L117W Disease P05106 1TYE B L196P Disease P05106 1TYE B L262P Disease P05106 1TYE B M124V Disease P05106 1TYE B M295L Disease P05106 1TYE B Q143R *Neutral P05106 1TYE B R143Q Neutral P05106 1TYE B R214Q Disease P05106 1TYE B R214W Disease P05106 1TYE B R216Q Disease P05106 1TYE B S162L Disease P05106 1TYE B Y115C Disease P05112 2B8U A C3R Neutral P05112 2B8U A R3C *Neutral P05121 1LJ5 A H2P Neutral P05121 1LJ5 A P2H *Neutral P05154 3DY0 A E86K *Neutral P05154 3DY0 A K86E Neutral P05154 3DY0 A L96P Neutral P05154 3DY0 A P96L *Neutral P05154 3DY0 A A102P *Neutral P05154 3DY0 A P102A Neutral P05155 1M6Q A A434E Disease P05155 1M6Q A A436T Disease P05155 1M6Q A A436V Disease P05155 1M6Q A A443V Disease P05155 1M6Q A D386V Disease P05155 1M6Q A E452Q *Neutral P05155 1M6Q A F455S Disease P05155 1M6Q A G323R Disease P05155 1M6Q A G407R Disease P05155 1M6Q A G471E Disease P05155 1M6Q A L459P Disease P05155 1M6Q A L459R Disease P05155 1M6Q A M458V *Neutral P05155 1M6Q A P467R Disease P05155 1M6Q A P476R Disease P05155 1M6Q A P476S Disease P05155 1M6Q A Q452E Neutral P05155 1M6Q A R444C Disease P05155 1M6Q A R444H Disease P05155 1M6Q A R444L Disease P05155 1M6Q A R444S Disease P05155 1M6Q A S286T *Neutral P05155 1M6Q A T286S Neutral P05155 1M6Q A T372P Disease P05155 1M6Q A T445P Disease P05155 1M6Q A V432E Disease P05155 1M6Q A V451E Disease P05155 1M6Q A V451M Disease P05155 1M6Q A V458M Neutral P05161 2HJ8 A N90S *Neutral P05161 2HJ8 A S90N Neutral P05162 1HLC A I119V *Neutral P05162 1HLC A V119I Neutral P05164 1MHL C C438R *Neutral P05164 1MHL C E517Q Neutral P05164 1MHL C I551V Neutral P05164 1MHL C Q517E *Neutral P05164 1MHL C R403W Disease P05164 1MHL C R438C Neutral P05164 1MHL C V551I *Neutral P05177 2HI4 A G73R Neutral P05177 2HI4 A M83T *Neutral P05177 2HI4 A P42R Neutral P05177 2HI4 A R42P *Neutral P05177 2HI4 A R73G *Neutral P05177 2HI4 A T83M Neutral P05177 2HI4 A C212S *Neutral P05177 2HI4 A C406Y Neutral P05177 2HI4 A F111L *Neutral P05177 2HI4 A F186L Neutral P05177 2HI4 A F205V Neutral P05177 2HI4 A F386I *Neutral P05177 2HI4 A G299S Neutral P05177 2HI4 A H456R *Neutral P05177 2HI4 A I314V Neutral P05177 2HI4 A I386F Neutral P05177 2HI4 A I438T *Neutral P05177 2HI4 A L111F Neutral P05177 2HI4 A L186F *Neutral P05177 2HI4 A Q377R *Neutral P05177 2HI4 A R281W Neutral P05177 2HI4 A R377Q Neutral P05177 2HI4 A R456H Neutral P05177 2HI4 A R457W Neutral P05177 2HI4 A S212C Neutral P05177 2HI4 A S299G *Neutral P05177 2HI4 A T438I Neutral P05177 2HI4 A V205F *Neutral P05177 2HI4 A V314I *Neutral P05177 2HI4 A W281R *Neutral P05177 2HI4 A W457R *Neutral P05177 2HI4 A Y406C *Neutral P05187 1ZED A L3P *Neutral P05187 1ZED A P3L Neutral P05187 1ZED A I67L Neutral P05187 1ZED A L67I *Neutral P05187 1ZED A E429G Neutral P05187 1ZED A G429E *Neutral P05187 1ZED A H241R *Neutral P05187 1ZED A P209R *Neutral P05187 1ZED A R209P Neutral P05187 1ZED A R241H Neutral P05230 1RY7 A E21G *Neutral P05230 1RY7 A G21E Neutral P05231 1IL6 A D135E Neutral P05231 1IL6 A D135V Neutral P05231 1IL6 A E135D *Neutral P05231 1IL6 A V135D *Neutral P05362 1IC1 A K128N Neutral P05362 1IC1 A N128K *Neutral P05412 1S9K E M307T *Neutral P05412 1S9K E T307M Neutral P05452 1TN3 A G85S *Neutral P05452 1TN3 A S85G Neutral P05455 2VOO A P48S Neutral P05455 2VOO A S48P *Neutral P05546 1JMJ B E428K Disease P05546 1JMJ B K218R Neutral P05546 1JMJ B L110V Neutral P05546 1JMJ B M423T *Neutral P05546 1JMJ B P443L Disease P05546 1JMJ B R189H Disease P05546 1JMJ B R218K *Neutral P05546 1JMJ B T423M Neutral P05546 1JMJ B V110L *Neutral P05813 1LEU A I110L *Neutral P05813 1LEU A L110I Neutral P06126 1XZ0 A C51W *Neutral P06126 1XZ0 A I13T Neutral P06126 1XZ0 A T13I *Neutral P06126 1XZ0 A W51C Neutral P06132 1R3Q A A80G Disease P06132 1R3Q A A80S Disease P06132 1R3Q A F46L Disease P06132 1R3Q A G25E Disease P06132 1R3Q A P62L Disease P06132 1R3Q A E167K Disease P06132 1R3Q A E218K Disease P06132 1R3Q A F229L Disease P06132 1R3Q A F232L Disease P06132 1R3Q A G156D Disease P06132 1R3Q A G281E Disease P06132 1R3Q A G281V Disease P06132 1R3Q A G303S Disease P06132 1R3Q A G318R Disease P06132 1R3Q A H220P Disease P06132 1R3Q A I260T Disease P06132 1R3Q A I334T Disease P06132 1R3Q A L161Q Disease P06132 1R3Q A L195F Disease P06132 1R3Q A L216Q Disease P06132 1R3Q A L253Q Disease P06132 1R3Q A L282R Disease P06132 1R3Q A M165R Disease P06132 1R3Q A M324T Disease P06132 1R3Q A N304K Disease P06132 1R3Q A P235S Disease P06132 1R3Q A R142Q Disease P06132 1R3Q A R144P Disease P06132 1R3Q A R193P Disease P06132 1R3Q A R292G Disease P06132 1R3Q A R332H Disease P06132 1R3Q A S219F Disease P06132 1R3Q A V134Q Disease P06132 1R3Q A Y311C Disease P06239 1LKK A G201S Neutral P06239 1LKK A S201G *Neutral P06239 2OF2 A A353V Disease P06239 2OF2 A P447L Disease P06280 3GXP B A97V Disease P06280 3GXP B C52R Disease P06280 3GXP B C52S Disease P06280 3GXP B C56F Disease P06280 3GXP B C56G Disease P06280 3GXP B C56Y Disease P06280 3GXP B C94S Disease P06280 3GXP B C94Y Disease P06280 3GXP B D92H Disease P06280 3GXP B D92Y Disease P06280 3GXP B D93G Disease P06280 3GXP B E59K Disease P06280 3GXP B E66Q Disease P06280 3GXP B G35R Disease P06280 3GXP B G85D Disease P06280 3GXP B H46R Disease P06280 3GXP B H46Y Disease P06280 3GXP B I91T Disease P06280 3GXP B L32P Disease P06280 3GXP B L89P Disease P06280 3GXP B L89R Disease P06280 3GXP B M42V Disease P06280 3GXP B M72V Disease P06280 3GXP B N34S Disease P06280 3GXP B P40L Disease P06280 3GXP B P40S Disease P06280 3GXP B R49L Disease P06280 3GXP B R49P Disease P06280 3GXP B R49S Disease P06280 3GXP B S65T Disease P06280 3GXP B W47G Disease P06280 3GXP B W95S Disease P06280 3GXP B Y86C Disease P06280 3GXP B A143P Disease P06280 3GXP B A143T Disease P06280 3GXP B A156T Disease P06280 3GXP B A156V Disease P06280 3GXP B A230T Disease P06280 3GXP B A288D Disease P06280 3GXP B A377D Disease P06280 3GXP B C142R Disease P06280 3GXP B C142Y Disease P06280 3GXP B C172R Disease P06280 3GXP B C172Y Disease P06280 3GXP B C202W Disease P06280 3GXP B C202Y Disease P06280 3GXP B C223G Disease P06280 3GXP B C378Y Disease P06280 3GXP B D165V Disease P06280 3GXP B D170V Disease P06280 3GXP B D231N Disease P06280 3GXP B D244H Disease P06280 3GXP B D244N Disease P06280 3GXP B D264V Disease P06280 3GXP B D266H Disease P06280 3GXP B D266N Disease P06280 3GXP B D266V Disease P06280 3GXP B D313Y Disease P06280 3GXP B E341K Disease P06280 3GXP B E358K Disease P06280 3GXP B F113L Disease P06280 3GXP B F113S Disease P06280 3GXP B G128E Disease P06280 3GXP B G138R Disease P06280 3GXP B G144V Disease P06280 3GXP B G163V Disease P06280 3GXP B G183D Disease P06280 3GXP B G258R Disease P06280 3GXP B G260A Disease P06280 3GXP B G261D Disease P06280 3GXP B G328A Disease P06280 3GXP B G328R Disease P06280 3GXP B G361R Disease P06280 3GXP B G373D Disease P06280 3GXP B G373S Disease P06280 3GXP B I219N Disease P06280 3GXP B I242N Disease P06280 3GXP B I289F Disease P06280 3GXP B L131P Disease P06280 3GXP B L166V Disease P06280 3GXP B M187V Disease P06280 3GXP B M267I Disease P06280 3GXP B M284T Disease P06280 3GXP B M296I Disease P06280 3GXP B M296V Disease P06280 3GXP B N215S Disease P06280 3GXP B N224D Disease P06280 3GXP B N224S Disease P06280 3GXP B N263S Disease P06280 3GXP B N272K Disease P06280 3GXP B N272S Disease P06280 3GXP B N298H Disease P06280 3GXP B N298K Disease P06280 3GXP B N298S Disease P06280 3GXP B N320K Disease P06280 3GXP B N320Y Disease P06280 3GXP B P146S Disease P06280 3GXP B P205T Disease P06280 3GXP B P259L Disease P06280 3GXP B P259R Disease P06280 3GXP B P265R Disease P06280 3GXP B P409A Disease P06280 3GXP B P409T Disease P06280 3GXP B Q279E Disease P06280 3GXP B Q279H Disease P06280 3GXP B Q280H Disease P06280 3GXP B Q321E Disease P06280 3GXP B Q327K Disease P06280 3GXP B R100K Disease P06280 3GXP B R100T Disease P06280 3GXP B R112C Disease P06280 3GXP B R112H Disease P06280 3GXP B R227Q Disease P06280 3GXP B R301Q Disease P06280 3GXP B R342Q Disease P06280 3GXP B R356W Disease P06280 3GXP B R363H Disease P06280 3GXP B S148N Disease P06280 3GXP B S148R Disease P06280 3GXP B S235C Disease P06280 3GXP B S297F Disease P06280 3GXP B T410A Disease P06280 3GXP B V269A Disease P06280 3GXP B V316E Disease P06280 3GXP B W162C Disease P06280 3GXP B W162R Disease P06280 3GXP B W226R Disease P06280 3GXP B W236C Disease P06280 3GXP B W236L Disease P06280 3GXP B W287C Disease P06280 3GXP B W287G Disease P06280 3GXP B W340R Disease P06280 3GXP B Y134S Disease P06280 3GXP B Y216D Disease P06396 1D4X G A78T Neutral P06396 1D4X G T78A *Neutral P06396 1KCQ A D187N Disease P06396 1KCQ A D187Y Disease P06400 1AD6 A A525G Neutral P06400 1AD6 A G525A *Neutral P06400 1AD6 A H549Y Disease P06400 1AD6 A K436Q *Neutral P06400 1AD6 A K447Q Disease P06400 1AD6 A K530R Disease P06400 1AD6 A M457R Disease P06400 1AD6 A Q436K Neutral P06400 1AD6 A R500G Disease P06401 1SR7 B L865S *Neutral P06401 1SR7 B S865L Neutral P06401 2C7A A I625R *Neutral P06401 2C7A A R625I Neutral P06702 1K96 A H27R Neutral P06702 1K96 A I83T Neutral P06702 1K96 A R27H *Neutral P06702 1K96 A T83I *Neutral P06702 1XK4 D H20R Neutral P06702 1XK4 D R20H *Neutral P06703 1K96 A D90G *Neutral P06703 1K96 A G90D Neutral P06703 1K96 A N69S Neutral P06703 1K96 A S69N *Neutral P06733 1TE6 B A394T *Neutral P06733 1TE6 B T394A Neutral P06733 2PSN C K176N *Neutral P06733 2PSN C N176K Neutral P06733 2PSN C P324Q Neutral P06733 2PSN C Q324P *Neutral P06734 1HLI A Q284R *Neutral P06734 1HLI A R284Q Neutral P06744 1IAT A T4I Disease P06744 1IAT A H19P Disease P06744 1IAT A R74G Disease P06744 1IAT A R82W Disease P06744 1IAT A A299P Disease P06744 1IAT A D538N Disease P06744 1IAT A E494K Disease P06744 1IAT A G158S Disease P06744 1IAT A H307R *Neutral P06744 1IAT A H388R Disease P06744 1IAT A I207T Neutral P06744 1IAT A I524T Disease P06744 1IAT A L338P Disease P06744 1IAT A L486F Disease P06744 1IAT A L516V Disease P06744 1IAT A Q342R Disease P06744 1IAT A R272H Disease P06744 1IAT A R307H Neutral P06744 1IAT A R346C Disease P06744 1IAT A R346H Disease P06744 1IAT A R471H Disease P06744 1IAT A S277L Disease P06744 1IAT A T194I Disease P06744 1IAT A T207I *Neutral P06744 1IAT A T223M Disease P06744 1IAT A T374R Disease P06744 1IAT A V100M Disease P06746 2FMP A P242R Neutral P06746 2FMP A R242P *Neutral P06881 1LS7 A D57N Neutral P06881 1LS7 A N57D *Neutral P07108 2CB8 A D39N Neutral P07108 2CB8 A G86R Neutral P07108 2CB8 A M71V Neutral P07108 2CB8 A N39D *Neutral P07108 2CB8 A R86G *Neutral P07108 2CB8 A V71M *Neutral P07195 1I0Z A M174V Neutral P07195 1I0Z A V174M *Neutral P07225 1Z6C A C200S Disease P07225 1Z6C A C206G Disease P07225 1Z6C A C224R Disease P07225 1Z6C A C224W Disease P07225 1Z6C A C226S Disease P07225 1Z6C A D202N Disease P07225 1Z6C A D204G Disease P07225 1Z6C A E163G Disease P07225 1Z6C A E208K Disease P07225 1Z6C A N217S Disease P07225 1Z6C A R192K Disease P07225 1Z6C A Y225C Disease P07288 2ZCH P E23K Neutral P07288 2ZCH P K23E *Neutral P07288 2ZCH P I163T Neutral P07288 2ZCH P T163I *Neutral P07316 1LEU A I72S *Neutral P07316 1LEU A R89T Neutral P07316 1LEU A S72I Neutral P07316 1LEU A T89R *Neutral P07320 1HK0 X P23S Disease P07320 1HK0 X P23T Disease P07320 1HK0 X R14C Disease P07320 1HK0 X R58H Disease P07320 1HK0 X E107A Disease P07320 1HK0 X M102V Neutral P07320 1HK0 X V102M *Neutral P07339 1LYA B F165I Disease P07339 1LYA B W319C Disease P07355 2HYV A L97V *Neutral P07355 2HYV A V97L Neutral P07359 1K13 A C30R Disease P07359 1K13 A F35L *Neutral P07359 1K13 A H21R *Neutral P07359 1K13 A L22F Disease P07359 1K13 A L35F Neutral P07359 1K13 A L94P Disease P07359 1K13 A R21H Neutral P07359 1K13 A A121V Disease P07359 1K13 A M110T *Neutral P07359 1K13 A T110M Neutral P07384 2ARY A A103T *Neutral P07384 2ARY A T103A Neutral P07476 1EU0 A K312Q *Neutral P07476 1EU0 A Q312K Neutral P07602 2GTG A C78F Disease P07602 2GTG A L39P Disease P07741 1ZN8 B D65V Disease P07741 1ZN8 B C153R Disease P07741 1ZN8 B L110P Disease P07741 1ZN8 B M136T Disease P07741 1ZN8 B Q121R Neutral P07741 1ZN8 B R121Q *Neutral P07741 1ZN8 B V150F Disease P07858 1GMY A L12P *Neutral P07858 1GMY A P12L Neutral P07858 1GMY A N156S *Neutral P07858 1GMY A S156N Neutral P07902 1R3A A A81T Disease P07902 1R3A A D28Y Disease P07902 1R3A A D98N Disease P07902 1R3A A G55C Disease P07902 1R3A A I32N Disease P07902 1R3A A L62M Neutral P07902 1R3A A L74P Disease P07902 1R3A A M62L *Neutral P07902 1R3A A N97S Disease P07902 1R3A A Q38P Disease P07902 1R3A A R51L Disease P07902 1R3A A R51Q Disease P07902 1R3A A R67C Disease P07902 1R3A A S45L Disease P07902 1R3A A V44L Disease P07902 1R3A A V44M Disease P07902 1R3A A A199T Disease P07902 1R3A A A320T Disease P07902 1R3A A A330V Disease P07902 1R3A A C130Y Disease P07902 1R3A A D113N Disease P07902 1R3A A D314N *Neutral P07902 1R3A A E203K Disease P07902 1R3A A E291K Disease P07902 1R3A A E308K Disease P07902 1R3A A F117S Disease P07902 1R3A A F171S Disease P07902 1R3A A F194L Disease P07902 1R3A A F294Y Disease P07902 1R3A A G179D Disease P07902 1R3A A H114L Disease P07902 1R3A A H132Y Disease P07902 1R3A A H184Q Disease P07902 1R3A A H319Q Disease P07902 1R3A A I198M Disease P07902 1R3A A I198T Disease P07902 1R3A A K127E Disease P07902 1R3A A K229N Disease P07902 1R3A A K285N Disease P07902 1R3A A K334R Disease P07902 1R3A A L139P Disease P07902 1R3A A L195P Disease P07902 1R3A A L217P Disease P07902 1R3A A L226P Disease P07902 1R3A A L282V Disease P07902 1R3A A L289R Disease P07902 1R3A A M129T Disease P07902 1R3A A M142K Disease P07902 1R3A A M142V Disease P07902 1R3A A M336L Disease P07902 1R3A A N314D Neutral P07902 1R3A A P183T Disease P07902 1R3A A P324S Disease P07902 1R3A A P325L Disease P07902 1R3A A Q118H Disease P07902 1R3A A Q188R Disease P07902 1R3A A Q212H Disease P07902 1R3A A Q252H Disease P07902 1R3A A Q317H Disease P07902 1R3A A Q317R Disease P07902 1R3A A Q344K Disease P07902 1R3A A R123G Disease P07902 1R3A A R123Q Disease P07902 1R3A A R148G Disease P07902 1R3A A R148Q Disease P07902 1R3A A R148W Disease P07902 1R3A A R201H Disease P07902 1R3A A R204P Disease P07902 1R3A A R231H Disease P07902 1R3A A R258C Disease P07902 1R3A A R259W Disease P07902 1R3A A R262P Disease P07902 1R3A A R272G Disease P07902 1R3A A R328H Disease P07902 1R3A A R333G Disease P07902 1R3A A R333Q Disease P07902 1R3A A R333W Disease P07902 1R3A A S135L Disease P07902 1R3A A S135W Disease P07902 1R3A A S143L Disease P07902 1R3A A S192N Disease P07902 1R3A A S329F Disease P07902 1R3A A T138M Disease P07902 1R3A A T350A Disease P07902 1R3A A V125A Disease P07902 1R3A A V150L Disease P07902 1R3A A V151A Disease P07902 1R3A A W154G Disease P07902 1R3A A W167R Disease P07902 1R3A A W249R Disease P07902 1R3A A Y209C Disease P07902 1R3A A Y209S Disease P07902 1R3A A Y251C Disease P07902 1R3A A Y251S Disease P07902 1R3A A Y323D Disease P07902 1R3A A Y323H Disease P07949 1XPD A E53Q Disease P07949 1XPD A E59D Disease P07949 1XPD A L81F Disease P07949 1XPD A R40T Neutral P07949 1XPD A S56P Disease P07949 1XPD A S58R Disease P07949 1XPD A T40R *Neutral P07949 1XPD A V69I Disease P07949 1XPD A V95L Disease P07949 1XPD A V95M Disease P07949 1XPD A Y82F Disease P07949 1XPD A A174F Disease P07949 1XPD A C273R *Neutral P07949 1XPD A E212K Disease P07949 1XPD A F184L Disease P07949 1XPD A G185S Disease P07949 1XPD A K198E Disease P07949 1XPD A M209T Disease P07949 1XPD A M271T Disease P07949 1XPD A P264L Disease P07949 1XPD A R104Q Disease P07949 1XPD A R135L Disease P07949 1XPD A R164Q Disease P07949 1XPD A R188Q Disease P07949 1XPD A R263G Disease P07949 1XPD A R273C Neutral P07949 1XPD A S117Y *Neutral P07949 1XPD A S182A Disease P07949 1XPD A S213F Disease P07949 1XPD A S213Y Neutral P07949 1XPD A T237M Disease P07949 1XPD A Y117S Neutral P07949 1XPD A Y213S *Neutral P07996 1LSL A A505T *Neutral P07996 1LSL A T505A Neutral P08107 2E8A A D110E *Neutral P08107 2E8A A E110D Neutral P08118 2IZ3 A I5M Neutral P08118 2IZ3 A M5I *Neutral P08118 2IZ3 A A60D *Neutral P08118 2IZ3 A D60A Neutral P08118 2IZ3 A D72G Neutral P08118 2IZ3 A E71G Neutral P08118 2IZ3 A G71E *Neutral P08118 2IZ3 A G72D *Neutral P08118 2IZ3 A I67T Neutral P08118 2IZ3 A L78V *Neutral P08118 2IZ3 A Q33R Neutral P08118 2IZ3 A R32W *Neutral P08118 2IZ3 A R33Q *Neutral P08118 2IZ3 A T67I *Neutral P08118 2IZ3 A V78L Neutral P08118 2IZ3 A W32R Neutral P08134 2GCN A D120H Neutral P08134 2GCN A H120D *Neutral P08174 1OJW B L20R *Neutral P08174 1OJW B R20L Neutral P08236 1BHG A C38G Disease P08236 1BHG A P30S Disease P08236 1BHG A S52F Disease P08236 1BHG A A354V Disease P08236 1BHG A A619V Disease P08236 1BHG A D152G Disease P08236 1BHG A D362N Disease P08236 1BHG A E150K Disease P08236 1BHG A E540K Disease P08236 1BHG A F376L *Neutral P08236 1BHG A G136R Disease P08236 1BHG A G572D Disease P08236 1BHG A G607A Disease P08236 1BHG A H351Y Disease P08236 1BHG A K350N Disease P08236 1BHG A K606N Disease P08236 1BHG A L176F Disease P08236 1BHG A L243P Disease P08236 1BHG A L376F Neutral P08236 1BHG A N339S Disease P08236 1BHG A P148S Disease P08236 1BHG A P364L Disease P08236 1BHG A P408S Disease P08236 1BHG A P415L Disease P08236 1BHG A R216W Disease P08236 1BHG A R374C Disease P08236 1BHG A R382C Disease P08236 1BHG A R382H Disease P08236 1BHG A R435P Disease P08236 1BHG A R477W Disease P08236 1BHG A R577L Disease P08236 1BHG A R611W Disease P08236 1BHG A W627C Disease P08236 1BHG A Y320C Disease P08236 1BHG A Y320S Disease P08236 1BHG A Y495C Disease P08236 1BHG A Y508C Disease P08236 1BHG A Y626H Disease P08246 2Z7F E G18V Disease P08246 2Z7F E L82V *Neutral P08246 2Z7F E V82L Neutral P08246 2Z7F E R186Q Disease P08246 2Z7F E V164F Disease P08253 1GEN A L621V *Neutral P08253 1GEN A V621L Neutral P08263 1K3Y A P113Q Neutral P08263 1K3Y A Q113P *Neutral P08311 1CGH A N119S Neutral P08311 1CGH A S119N *Neutral P08514 2VDR A L55P Disease P08514 2VDR A A108V Disease P08514 2VDR A C130W Disease P08514 2VDR A E324K Disease P08514 2VDR A F171C Disease P08514 2VDR A F191L Disease P08514 2VDR A F289S Disease P08514 2VDR A G236E Disease P08514 2VDR A G242D Disease P08514 2VDR A G349D Disease P08514 2VDR A G381R Disease P08514 2VDR A G418D Disease P08514 2VDR A I374T Disease P08514 2VDR A L183P Disease P08514 2VDR A P145A Disease P08514 2VDR A P145L Disease P08514 2VDR A R327H Disease P08514 2VDR A T176I Disease P08514 2VDR A V298F Disease P08514 2VDR A Y143H Disease P08519 1KIV A M66T Neutral P08519 1KIV A T66M *Neutral P08559 3EXE E H84D Disease P08559 3EXE E R43C Disease P08559 3EXE E A170T Disease P08559 3EXE E D229A Disease P08559 3EXE E D286N Disease P08559 3EXE E D304E *Neutral P08559 3EXE E E304D Neutral P08559 3EXE E F176L Disease P08559 3EXE E G133R Disease P08559 3EXE E H263L Disease P08559 3EXE E L253M *Neutral P08559 3EXE E M181V Disease P08559 3EXE E M253L Neutral P08559 3EXE E P188L Disease P08559 3EXE E R234G Disease P08559 3EXE E R234Q Disease P08559 3EXE E R259H Disease P08559 3EXE E R273C Disease P08559 3EXE E R273H Disease P08559 3EXE E R349H Disease P08559 3EXE E T202A Disease P08559 3EXE E V138M Disease P08559 3EXE E Y214N Disease P08567 1XX0 A K340R Neutral P08567 1XX0 A R340K *Neutral P08581 1UX3 A A320V Neutral P08581 1UX3 A D168E *Neutral P08581 1UX3 A E168D Neutral P08581 1UX3 A I316M Neutral P08581 1UX3 A L156S *Neutral P08581 1UX3 A L238S Neutral P08581 1UX3 A M316I *Neutral P08581 1UX3 A N375S Neutral P08581 1UX3 A Q143R *Neutral P08581 1UX3 A R143Q Neutral P08581 1UX3 A S156L Neutral P08581 1UX3 A S238L *Neutral P08581 1UX3 A S375N *Neutral P08581 1UX3 A V320A *Neutral P08581 2G15 A D1228H Disease P08581 2G15 A D1228N Disease P08581 2G15 A H1094L Disease P08581 2G15 A H1094R Disease P08581 2G15 A H1094Y Disease P08581 2G15 A H1106D Disease P08581 2G15 A K1244R Disease P08581 2G15 A L1195V Disease P08581 2G15 A M1131T Disease P08581 2G15 A M1250I Disease P08581 2G15 A M1250T Disease P08581 2G15 A T1173I Disease P08581 2G15 A V1092I Disease P08581 2G15 A V1188L Disease P08581 2G15 A V1220I Disease P08581 2G15 A Y1230C Disease P08581 2G15 A Y1230D Disease P08581 2G15 A Y1230H Disease P08582 1CB6 A A1010T Neutral P08582 1CB6 A K1028R Neutral P08582 1CB6 A R1028K *Neutral P08582 1CB6 A T1010A *Neutral P08582 1RYO A L23R *Neutral P08582 1RYO A R23L Neutral P08582 1RYO A G258S Neutral P08582 1RYO A S258G *Neutral P08582 2HAV A E627K *Neutral P08582 2HAV A G543V Neutral P08582 2HAV A I429V *Neutral P08582 2HAV A K627E Neutral P08582 2HAV A P570S Neutral P08582 2HAV A P626T *Neutral P08582 2HAV A S570P *Neutral P08582 2HAV A T626P Neutral P08582 2HAV A V429I Neutral P08582 2HAV A V543G *Neutral P08588 1ND8 A F42I *Neutral P08588 1ND8 A I12L Neutral P08588 1ND8 A I42F Neutral P08588 1ND8 A L12I *Neutral P08588 1ND8 A A335V Neutral P08588 1ND8 A F339Y *Neutral P08588 1ND8 A L215S *Neutral P08588 1ND8 A Q223R *Neutral P08588 1ND8 A R223Q Neutral P08588 1ND8 A S215L Neutral P08588 1ND8 A V335A *Neutral P08588 1ND8 A Y339F Neutral P08588 1OEA A I248L Neutral P08588 1OEA A L248I *Neutral P08588 1T78 A E330G Neutral P08588 1T78 A G330E *Neutral P08588 1UPE A A50V Neutral P08588 1UPE A V50A *Neutral P08588 1UPE A H300R *Neutral P08588 1UPE A R300H Neutral P08588 1ZV0 B A163T Neutral P08588 1ZV0 B A244S Neutral P08588 1ZV0 B S244A *Neutral P08588 1ZV0 B T163A *Neutral P08588 2B0X A A224D Neutral P08588 2B0X A D224A *Neutral P08588 2B6Q A L191P *Neutral P08588 2B6Q A M168V *Neutral P08588 2B6Q A N178T Neutral P08588 2B6Q A P191L Neutral P08588 2B6Q A T178N *Neutral P08588 2B6Q A V168M Neutral P08588 2CDW A C353R *Neutral P08588 2CDW A M265T *Neutral P08588 2CDW A R353C Neutral P08588 2CDW A T265M Neutral P08588 2G1X A E374K Neutral P08588 2G1X A F219L Neutral P08588 2G1X A I367V Neutral P08588 2G1X A K374E *Neutral P08588 2G1X A L219F *Neutral P08588 2G1X A V367I *Neutral P08603 1HCC A C33Y Disease P08603 1HCC A D10E *Neutral P08603 1HCC A E10D Neutral P08603 1HCC A Q24H Disease P08603 1HCC A T30M Disease P08603 1HCC A W52C Disease P08603 1HCC A Y25H Disease P08603 1HFH A C50S Disease P08603 1HFH A H28R Disease P08603 1HFH A I25S *Neutral P08603 1HFH A S25I Neutral P08603 2G7I A C1163W Disease P08603 2G7I A D1119G Disease P08603 2G7I A E1143Q *Neutral P08603 2G7I A E1198A Disease P08603 2G7I A F1199S Disease P08603 2G7I A G1194D Disease P08603 2G7I A L1189R Disease P08603 2G7I A P1226S Disease P08603 2G7I A Q1143E Neutral P08603 2G7I A R1210C Disease P08603 2G7I A R1215G Disease P08603 2G7I A R1215Q Disease P08603 2G7I A S1191L Disease P08603 2G7I A T1184R Disease P08603 2G7I A V1134G Disease P08603 2G7I A V1197A Disease P08603 2G7I A W1157R Disease P08603 2G7I A W1183L Disease P08603 2G7I A W1183R Disease P08603 2G7I A Y1142D Disease P08603 2JGX A C431S Disease P08603 2JGX A H402Y *Neutral P08603 2JGX A Q400K Disease P08603 2JGX A Y402H Neutral P08603 2RLP A I62V *Neutral P08603 2RLP A R78G Disease P08603 2RLP A V62I Neutral P08603 2RLP A R127L Disease P08631 1BU1 A L105M *Neutral P08631 1BU1 A M105L Neutral P08686 2GEG C G64E Disease P08686 2GEG C G90V Disease P08686 2GEG C H62L Disease P08686 2GEG C P30L Disease P08686 2GEG C P30Q Disease P08686 2GEG C A362V Disease P08686 2GEG C C169Y Disease P08686 2GEG C D183E Neutral P08686 2GEG C E183D *Neutral P08686 2GEG C E380D Disease P08686 2GEG C G178A Disease P08686 2GEG C G291C Disease P08686 2GEG C G291R Disease P08686 2GEG C G291S Disease P08686 2GEG C G424S Disease P08686 2GEG C H365Y Disease P08686 2GEG C I172N Disease P08686 2GEG C I236N Disease P08686 2GEG C L261P Disease P08686 2GEG C L300F Disease P08686 2GEG C L317M Disease P08686 2GEG C L363W Disease P08686 2GEG C M239K Disease P08686 2GEG C M283L Disease P08686 2GEG C P105L Disease P08686 2GEG C P453S Disease P08686 2GEG C P482S Disease P08686 2GEG C R124H Disease P08686 2GEG C R339H Disease P08686 2GEG C R341P Disease P08686 2GEG C R341W Disease P08686 2GEG C R354C Disease P08686 2GEG C R354H Disease P08686 2GEG C R356P Disease P08686 2GEG C R356Q Disease P08686 2GEG C R356W Disease P08686 2GEG C R408C Disease P08686 2GEG C R426H Disease P08686 2GEG C R435C Disease P08686 2GEG C R479L Disease P08686 2GEG C R483P Disease P08686 2GEG C R483Q Disease P08686 2GEG C R483W Disease P08686 2GEG C S301Y Disease P08686 2GEG C V211L Disease P08686 2GEG C V237E Disease P08686 2GEG C V281G Disease P08686 2GEG C V281L Disease P08709 2BZ6 H D95V *Neutral P08709 2BZ6 H V95D Neutral P08709 2BZ6 H A150T Neutral P08709 2BZ6 H E236K Neutral P08709 2BZ6 H K236E *Neutral P08709 2BZ6 H Q204R *Neutral P08709 2BZ6 H R204Q Neutral P08709 2BZ6 H S165T *Neutral P08709 2BZ6 H T150A *Neutral P08709 2BZ6 H T165S Neutral P08833 1ZT3 A I183V *Neutral P08833 1ZT3 A V183I Neutral P08865 3BCH A R117W Neutral P08865 3BCH A W117R *Neutral P09104 1TE6 B A263P *Neutral P09104 1TE6 B P263A Neutral P09211 2A2R A D168G *Neutral P09211 2A2R A G168D Neutral P09237 1MMQ A D142G *Neutral P09237 1MMQ A G142D Neutral P09237 1MMQ A L245P *Neutral P09237 1MMQ A P245L Neutral P09417 1HDR A G16R Disease P09417 1HDR A G16V Disease P09417 1HDR A G17D Disease P09417 1HDR A G22D Disease P09417 1HDR A L13P Disease P09417 1HDR A L73P Disease P09417 1HDR A Q65R Disease P09417 1HDR A S50T Neutral P09417 1HDR A T50S *Neutral P09417 1HDR A W35R Disease P09417 1HDR A F211C Disease P09417 1HDR A G148R Disease P09417 1HDR A G150S Disease P09417 1HDR A G169S Disease P09417 1HDR A H157Y Disease P09417 1HDR A P144L Disease P09417 1HDR A W107G Disease P09417 1HDR A Y149C Disease P09488 1XW6 A S209T Neutral P09488 1XW6 A T209S *Neutral P09525 2ZOC A M85T *Neutral P09525 2ZOC A T85M Neutral P09601 1N45 A L106P *Neutral P09601 1N45 A P106L Neutral P09601 1NI6 C D7H Neutral P09601 1NI6 C H7D *Neutral P09622 1ZMD E L296V Neutral P09622 1ZMD E V296L *Neutral P09651 1U1Q A N73S Neutral P09651 1U1Q A S73N *Neutral P09874 2RCW A A101V *Neutral P09874 2RCW A K279R Neutral P09874 2RCW A R279K *Neutral P09874 2RCW A V101A Neutral P09874 2RIQ A I334V *Neutral P09874 2RIQ A V334I Neutral P09917 2ABV A E253K Neutral P09917 2ABV A K253E *Neutral P09936 2ETL A S18Y Neutral P09936 2ETL A Y18S *Neutral P09960 3FUN A H130Y *Neutral P09960 3FUN A Y130H Neutral P0C0L4 3G6J A D447E *Neutral P0C0L4 3G6J A E447D Neutral P0CG30 1LJR A E129K Neutral P0CG30 1LJR A I139M *Neutral P0CG30 1LJR A K129E *Neutral P0CG30 1LJR A M139I Neutral P0CG30 2C3N A A21T Neutral P0CG30 2C3N A T21A *Neutral P0CG30 2C3N A E173K Neutral P0CG30 2C3N A K173E *Neutral P10144 1FQ3 A A88P *Neutral P10144 1FQ3 A P88A Neutral P10144 1FQ3 A Q48R Neutral P10144 1FQ3 A R48Q *Neutral P10153 1K2A A H73Q Neutral P10153 1K2A A Q73H *Neutral P10275 1XJ7 A I664N Disease P10275 2AM9 A A687V Disease P10275 2AM9 A A721T Disease P10275 2AM9 A A748D Disease P10275 2AM9 A A748T Disease P10275 2AM9 A A748V Disease P10275 2AM9 A A765T Disease P10275 2AM9 A A765V Disease P10275 2AM9 A A870G Disease P10275 2AM9 A A870V Disease P10275 2AM9 A A896T Disease P10275 2AM9 A C686R Disease P10275 2AM9 A C784Y Disease P10275 2AM9 A C806Y Disease P10275 2AM9 A D695H Disease P10275 2AM9 A D695N Disease P10275 2AM9 A D695V Disease P10275 2AM9 A D732N Disease P10275 2AM9 A D732Y Disease P10275 2AM9 A D767E Disease P10275 2AM9 A D793E *Neutral P10275 2AM9 A D864G Disease P10275 2AM9 A D864N Disease P10275 2AM9 A D879Y Disease P10275 2AM9 A D890N Disease P10275 2AM9 A E681K Disease P10275 2AM9 A E772A Disease P10275 2AM9 A E772G Disease P10275 2AM9 A E793D Neutral P10275 2AM9 A F754L Disease P10275 2AM9 A F754V Disease P10275 2AM9 A F764L Disease P10275 2AM9 A F794S Disease P10275 2AM9 A F827V Disease P10275 2AM9 A F856L Disease P10275 2AM9 A F891L Disease P10275 2AM9 A F916L Disease P10275 2AM9 A G683A Disease P10275 2AM9 A G688E Disease P10275 2AM9 A G708A Disease P10275 2AM9 A G708V Disease P10275 2AM9 A G724D Disease P10275 2AM9 A G743E Disease P10275 2AM9 A G743V Disease P10275 2AM9 A G750D Disease P10275 2AM9 A G750S Disease P10275 2AM9 A G820A Disease P10275 2AM9 A G909E Disease P10275 2AM9 A G909R Disease P10275 2AM9 A H874R Disease P10275 2AM9 A H874Y Disease P10275 2AM9 A H917R Disease P10275 2AM9 A I672T Disease P10275 2AM9 A I737T Disease P10275 2AM9 A I841S Disease P10275 2AM9 A I842T Disease P10275 2AM9 A I869M Disease P10275 2AM9 A I898T Disease P10275 2AM9 A K717E Disease P10275 2AM9 A K720E Disease P10275 2AM9 A K910R Disease P10275 2AM9 A L677P Disease P10275 2AM9 A L700M Disease P10275 2AM9 A L701F Disease P10275 2AM9 A L701H Disease P10275 2AM9 A L707R Disease P10275 2AM9 A L712F Disease P10275 2AM9 A L722F Disease P10275 2AM9 A L728S Disease P10275 2AM9 A L744F Disease P10275 2AM9 A L762F Disease P10275 2AM9 A L768P Disease P10275 2AM9 A L790F Disease P10275 2AM9 A L812F Disease P10275 2AM9 A L821V Disease P10275 2AM9 A L830P Disease P10275 2AM9 A L863R Disease P10275 2AM9 A L880Q Disease P10275 2AM9 A L881V Disease P10275 2AM9 A L907F Disease P10275 2AM9 A M742I Disease P10275 2AM9 A M742V Disease P10275 2AM9 A M745T Disease P10275 2AM9 A M749I Disease P10275 2AM9 A M749V Disease P10275 2AM9 A M780I Disease P10275 2AM9 A M787V Disease P10275 2AM9 A M807R Disease P10275 2AM9 A M807T Disease P10275 2AM9 A M807V Disease P10275 2AM9 A M886V Disease P10275 2AM9 A M895T Disease P10275 2AM9 A N705S Disease P10275 2AM9 A N705Y Disease P10275 2AM9 A N727K Disease P10275 2AM9 A N756S Disease P10275 2AM9 A N758T Disease P10275 2AM9 A N771H Disease P10275 2AM9 A P671H Disease P10275 2AM9 A P682T Disease P10275 2AM9 A P723S Disease P10275 2AM9 A P766S Disease P10275 2AM9 A P892L Disease P10275 2AM9 A P904H Disease P10275 2AM9 A P904S Disease P10275 2AM9 A P913S Disease P10275 2AM9 A Q670R Disease P10275 2AM9 A Q711E Disease P10275 2AM9 A Q733H Disease P10275 2AM9 A Q798E Disease P10275 2AM9 A Q902R Disease P10275 2AM9 A Q919R Disease P10275 2AM9 A R710T Disease P10275 2AM9 A R726L Disease P10275 2AM9 A R752Q Disease P10275 2AM9 A R774C Disease P10275 2AM9 A R774H Disease P10275 2AM9 A R779W Disease P10275 2AM9 A R788S Disease P10275 2AM9 A R831L Disease P10275 2AM9 A R831Q Disease P10275 2AM9 A R840C Disease P10275 2AM9 A R840G Disease P10275 2AM9 A R840H Disease P10275 2AM9 A R840S Disease P10275 2AM9 A R846G Disease P10275 2AM9 A R854K Disease P10275 2AM9 A R855C Disease P10275 2AM9 A R855H Disease P10275 2AM9 A R871G Disease P10275 2AM9 A S702A Disease P10275 2AM9 A S703C Disease P10275 2AM9 A S703G Disease P10275 2AM9 A S759F Disease P10275 2AM9 A S759P Disease P10275 2AM9 A S782N Disease P10275 2AM9 A S791P Disease P10275 2AM9 A S814N Disease P10275 2AM9 A S865P Disease P10275 2AM9 A T755A Disease P10275 2AM9 A T877A Disease P10275 2AM9 A T877S Disease P10275 2AM9 A V684I Disease P10275 2AM9 A V715M Disease P10275 2AM9 A V730M Disease P10275 2AM9 A V746M Disease P10275 2AM9 A V757A Disease P10275 2AM9 A V866E Disease P10275 2AM9 A V866L Disease P10275 2AM9 A V866M Disease P10275 2AM9 A V889M Disease P10275 2AM9 A V903M Disease P10275 2AM9 A V911L Disease P10275 2AM9 A W741R Disease P10275 2AM9 A W751R Disease P10275 2AM9 A Y763C Disease P10275 2AM9 A Y763H Disease P10275 2AM9 A Y834C Disease P10515 3B8K A D365N Neutral P10515 3B8K A N365D *Neutral P10632 2NNJ A K399R Neutral P10632 2NNJ A R399K *Neutral P10721 1QZJ A C691S Neutral P10721 1QZJ A D816V Disease P10721 1QZJ A D816Y Disease P10721 1QZJ A E583K Disease P10721 1QZJ A F584C Disease P10721 1QZJ A F584L Disease P10721 1QZJ A G601R Disease P10721 1QZJ A G664R Disease P10721 1QZJ A G812V Disease P10721 1QZJ A L656P Disease P10721 1QZJ A N715S *Neutral P10721 1QZJ A R791G Disease P10721 1QZJ A R796G Disease P10721 1QZJ A S691C *Neutral P10721 1QZJ A S715N Neutral P10721 1QZJ A T847P Disease P10746 1JR2 A L4F Disease P10746 1JR2 A V3F Disease P10746 1JR2 A A66V Disease P10746 1JR2 A A69T Disease P10746 1JR2 A C73R Disease P10746 1JR2 A P53L Disease P10746 1JR2 A S47P Disease P10746 1JR2 A T62A Disease P10746 1JR2 A V82F Disease P10746 1JR2 A V99A Disease P10746 1JR2 A Y19C Disease P10746 1JR2 A A104V Disease P10746 1JR2 A G171V *Neutral P10746 1JR2 A G188R Disease P10746 1JR2 A G188W Disease P10746 1JR2 A G225S Disease P10746 1JR2 A I129T Disease P10746 1JR2 A I219S Disease P10746 1JR2 A K124R Neutral P10746 1JR2 A R124K *Neutral P10746 1JR2 A S212P Disease P10746 1JR2 A T228M Disease P10746 1JR2 A V171G Neutral P10828 1NAX A A234T Disease P10828 1NAX A A268G Disease P10828 1NAX A A317T Disease P10828 1NAX A A335P Disease P10828 1NAX A C446R Disease P10828 1NAX A F459C Disease P10828 1NAX A G332R Disease P10828 1NAX A G345R Disease P10828 1NAX A G345S Disease P10828 1NAX A G345V Disease P10828 1NAX A G347E Disease P10828 1NAX A I431M Disease P10828 1NAX A K342I Disease P10828 1NAX A K443E Disease P10828 1NAX A L341P Disease P10828 1NAX A L346F Disease P10828 1NAX A M442V Disease P10828 1NAX A N331D Disease P10828 1NAX A P447T Disease P10828 1NAX A P453H Disease P10828 1NAX A P453L Disease P10828 1NAX A P453S Disease P10828 1NAX A P453T Disease P10828 1NAX A Q340H Disease P10828 1NAX A R243W Disease P10828 1NAX A R316H Disease P10828 1NAX A R320C Disease P10828 1NAX A R320H Disease P10828 1NAX A R338W Disease P10828 1NAX A R429Q Disease P10828 1NAX A R438H Disease P10828 1NAX A T426I Disease P10828 1NAX A V348E Disease P11086 2G72 B A98T *Neutral P11086 2G72 B T98A Neutral P11086 2G72 B A175T Neutral P11086 2G72 B C112R *Neutral P11086 2G72 B C188S *Neutral P11086 2G72 B H211L *Neutral P11086 2G72 B H254R *Neutral P11086 2G72 B L211H Neutral P11086 2G72 B L217Q Neutral P11086 2G72 B Q217L *Neutral P11086 2G72 B R112C Neutral P11086 2G72 B R254H Neutral P11086 2G72 B R276W *Neutral P11086 2G72 B S188C Neutral P11086 2G72 B T175A *Neutral P11086 2G72 B W276R Neutral P11117 1ND6 B A1327V *Neutral P11117 1ND6 B V1327A Neutral P11142 3FZH A D32Y Neutral P11142 3FZH A Y32D *Neutral P11171 1GG3 A I5V *Neutral P11171 1GG3 A V5I Neutral P11172 2WNS A G30S *Neutral P11172 2WNS A R96G Disease P11172 2WNS A S30G Neutral P11172 2WNS A V109G Disease P11172 3EX0 B G429R Disease P11172 3EX0 B I446V Neutral P11172 3EX0 B V446I *Neutral P11177 3EXE B L1V Neutral P11177 3EXE B V1L *Neutral P11177 3EXE B P314S Disease P11177 3EXE B Y102C Disease P11226 1HUP A N194Y Neutral P11226 1HUP A Y194N *Neutral P11245 2DSS _ R64W Neutral P11245 2DSS _ W64R *Neutral P11245 2DSS _ A214S *Neutral P11245 2DSS _ I149V *Neutral P11245 2DSS _ I207T *Neutral P11245 2DSS _ S214A Neutral P11245 2DSS _ T207I Neutral P11245 2DSS _ V149I Neutral P11309 1XWS A D142E *Neutral P11309 1XWS A E124Q Neutral P11309 1XWS A E135K Neutral P11309 1XWS A E142D Neutral P11309 1XWS A K135E *Neutral P11309 1XWS A Q124E *Neutral P11310 1EGE A C91Y Disease P11310 1EGE A I53T Disease P11310 1EGE A R28C Disease P11310 1EGE A T96I Disease P11310 1EGE A Y42H Disease P11310 1EGE A C219R Disease P11310 1EGE A G170R Disease P11310 1EGE A G242R Disease P11310 1EGE A G285R Disease P11310 1EGE A I350T Disease P11310 1EGE A K304E Disease P11310 1EGE A M124I Disease P11310 1EGE A M301T Disease P11310 1EGE A R181L Disease P11310 1EGE A R256T Disease P11310 1EGE A S220L Disease P11310 1EGE A S311R Disease P11310 1EGE A T168A Disease P11310 1EGE A Y327C Disease P11509 2FDV A A131S *Neutral P11509 2FDV A D419E *Neutral P11509 2FDV A E194K *Neutral P11509 2FDV A E419D Neutral P11509 2FDV A F118L Neutral P11509 2FDV A F392Y *Neutral P11509 2FDV A G479V Neutral P11509 2FDV A I471T Neutral P11509 2FDV A K194E Neutral P11509 2FDV A L110V *Neutral P11509 2FDV A L118F *Neutral P11509 2FDV A L485R *Neutral P11509 2FDV A M292V *Neutral P11509 2FDV A M365V *Neutral P11509 2FDV A P224S *Neutral P11509 2FDV A R203S Neutral P11509 2FDV A R485L Neutral P11509 2FDV A S131A Neutral P11509 2FDV A S203R *Neutral P11509 2FDV A S224P Neutral P11509 2FDV A S294T *Neutral P11509 2FDV A T294S Neutral P11509 2FDV A T471I *Neutral P11509 2FDV A V110L Neutral P11509 2FDV A V292M Neutral P11509 2FDV A V365M Neutral P11509 2FDV A V479G *Neutral P11509 2FDV A Y392F Neutral P11511 3EQM A C264R *Neutral P11511 3EQM A C437Y Disease P11511 3EQM A L375R *Neutral P11511 3EQM A M201T *Neutral P11511 3EQM A R264C Neutral P11511 3EQM A R365Q Disease P11511 3EQM A R375C Disease P11511 3EQM A R375L Neutral P11511 3EQM A R435C Disease P11511 3EQM A T201M Neutral P11532 1EG3 A F228L Disease P11586 1A4I B H293R *Neutral P11586 1A4I B K134R *Neutral P11586 1A4I B L162P *Neutral P11586 1A4I B P162L Neutral P11586 1A4I B R134K Neutral P11586 1A4I B R293H Neutral P11717 1GP0 A G1619R Neutral P11717 1GP0 A R1619G *Neutral P11766 2FZE A D352E Neutral P11766 2FZE A E352D *Neutral P11766 2FZE A I308V *Neutral P11766 2FZE A L162S Neutral P11766 2FZE A S162L *Neutral P11766 2FZE A V308I Neutral P11802 3G33 A N46S Disease P11802 3G33 A Q87R *Neutral P11802 3G33 A R29C Disease P11802 3G33 A R29H Disease P11802 3G33 A R87Q Neutral P11802 3G33 A H127R *Neutral P11802 3G33 A R127H Neutral P12018 2H32 A L103S *Neutral P12018 2H32 A S103L Neutral P12018 2H3N A D57N Neutral P12018 2H3N A N57D *Neutral P12104 1KZW A A54T Neutral P12104 1KZW A T54A *Neutral P12259 1FV4 H D79H Neutral P12259 1FV4 H H79D *Neutral P12259 1FV4 H C585R Disease P12259 1FV4 H I359T Disease P12259 1FV4 H K485R *Neutral P12259 1FV4 H M385T Neutral P12259 1FV4 H Q506R *Neutral P12259 1FV4 H R306T Disease P12259 1FV4 H R485K Neutral P12259 1FV4 H R506Q Neutral P12259 1FV4 H T385M *Neutral P12271 1XGG A M225K Disease P12271 1XGG A R150Q Disease P12271 1XGG A R233W Disease P12277 3B6R A K177R Neutral P12277 3B6R A L309S *Neutral P12277 3B6R A R177K *Neutral P12277 3B6R A S309L Neutral P12319 1J86 A K59R Neutral P12319 1J86 A N76S *Neutral P12319 1J86 A R59K *Neutral P12319 1J86 A S76N Neutral P12429 1AII A N20S *Neutral P12429 1AII A S20N Neutral P12429 1AII A I220N Neutral P12429 1AII A L252P *Neutral P12429 1AII A N220I *Neutral P12429 1AII A P252L Neutral P12544 1OP8 A M109T *Neutral P12544 1OP8 A T109M Neutral P12821 2C6N A A125T Neutral P12821 2C6N A A154T Neutral P12821 2C6N A A232S Neutral P12821 2C6N A A495V *Neutral P12821 2C6N A C215Y *Neutral P12821 2C6N A C231R *Neutral P12821 2C6N A D563G Neutral P12821 2C6N A G325R Neutral P12821 2C6N A G563D *Neutral P12821 2C6N A L231R *Neutral P12821 2C6N A L322P *Neutral P12821 2C6N A P322L Neutral P12821 2C6N A Q350R *Neutral P12821 2C6N A R231C Neutral P12821 2C6N A R231L Neutral P12821 2C6N A R325G *Neutral P12821 2C6N A R350Q Neutral P12821 2C6N A R532W Neutral P12821 2C6N A S232A *Neutral P12821 2C6N A T125A *Neutral P12821 2C6N A T154A *Neutral P12821 2C6N A V495A Neutral P12821 2C6N A W532R *Neutral P12821 2C6N A Y215C Neutral P12883 1IK2 A A26V Disease P12883 1IK2 A V39M Disease P12883 1IK2 A V59I Disease P12883 1IK2 A A196T Disease P12883 1IK2 A A223T Disease P12883 1IK2 A A355T Disease P12883 1IK2 A A385V Disease P12883 1IK2 A A428V Disease P12883 1IK2 A A430E Disease P12883 1IK2 A A550V Disease P12883 1IK2 A A728V Disease P12883 1IK2 A A742E Disease P12883 1IK2 A A797T Disease P12883 1IK2 A D587V Disease P12883 1IK2 A D778E Disease P12883 1IK2 A D778G Disease P12883 1IK2 A D778V Disease P12883 1IK2 A E328G Disease P12883 1IK2 A E466Q Neutral P12883 1IK2 A E483K Disease P12883 1IK2 A E499K Disease P12883 1IK2 A E500A Disease P12883 1IK2 A E743D Disease P12883 1IK2 A E774V Disease P12883 1IK2 A F244L Disease P12883 1IK2 A F312C Disease P12883 1IK2 A F513C Disease P12883 1IK2 A F764L Disease P12883 1IK2 A G256E Disease P12883 1IK2 A G407V Disease P12883 1IK2 A G425R Disease P12883 1IK2 A G571R Disease P12883 1IK2 A G584R Disease P12883 1IK2 A G584S Disease P12883 1IK2 A G716R Disease P12883 1IK2 A G733E Disease P12883 1IK2 A G741R Disease P12883 1IK2 A G741W Disease P12883 1IK2 A G768R Disease P12883 1IK2 A G823E Disease P12883 1IK2 A H576R Disease P12883 1IK2 A I201T Disease P12883 1IK2 A I263M Disease P12883 1IK2 A I263T Disease P12883 1IK2 A I443T Disease P12883 1IK2 A I511F Disease P12883 1IK2 A I511T Disease P12883 1IK2 A I736M Disease P12883 1IK2 A I736T Disease P12883 1IK2 A K146N Disease P12883 1IK2 A K207Q Disease P12883 1IK2 A K351E Disease P12883 1IK2 A K383N Disease P12883 1IK2 A K450E Disease P12883 1IK2 A K450T Disease P12883 1IK2 A K615N Disease P12883 1IK2 A K615Q Disease P12883 1IK2 A L227V Disease P12883 1IK2 A L390V Disease P12883 1IK2 A L517M Disease P12883 1IK2 A L601V Disease P12883 1IK2 A L796F Disease P12883 1IK2 A M349T Disease P12883 1IK2 A M435T Disease P12883 1IK2 A M515R Disease P12883 1IK2 A M515V Disease P12883 1IK2 A M659I Disease P12883 1IK2 A M822L Disease P12883 1IK2 A M822T Disease P12883 1IK2 A N187K Disease P12883 1IK2 A N232S Disease P12883 1IK2 A N479S Disease P12883 1IK2 A N602S Disease P12883 1IK2 A N696S Disease P12883 1IK2 A P211L Disease P12883 1IK2 A P731L Disease P12883 1IK2 A Q222K Disease P12883 1IK2 A Q466E *Neutral P12883 1IK2 A Q595R Disease P12883 1IK2 A Q734E Disease P12883 1IK2 A Q734P Disease P12883 1IK2 A R143G Disease P12883 1IK2 A R143Q Disease P12883 1IK2 A R143W Disease P12883 1IK2 A R190T Disease P12883 1IK2 A R204H Disease P12883 1IK2 A R249Q Disease P12883 1IK2 A R403L Disease P12883 1IK2 A R403Q Disease P12883 1IK2 A R403W Disease P12883 1IK2 A R453C Disease P12883 1IK2 A R453H Disease P12883 1IK2 A R663C Disease P12883 1IK2 A R663H Disease P12883 1IK2 A R663S Disease P12883 1IK2 A R671C Disease P12883 1IK2 A R694C Disease P12883 1IK2 A R694H Disease P12883 1IK2 A R712L Disease P12883 1IK2 A R719Q Disease P12883 1IK2 A R719W Disease P12883 1IK2 A R723C Disease P12883 1IK2 A R723G Disease P12883 1IK2 A R787C Disease P12883 1IK2 A R787H Disease P12883 1IK2 A S148I Disease P12883 1IK2 A S532P Disease P12883 1IK2 A S642L Disease P12883 1IK2 A S782N Disease P12883 1IK2 A T124I Disease P12883 1IK2 A T188N Disease P12883 1IK2 A T412N Disease P12883 1IK2 A T441M Disease P12883 1IK2 A V186L Disease P12883 1IK2 A V320M Disease P12883 1IK2 A V404L Disease P12883 1IK2 A V404M Disease P12883 1IK2 A V406M Disease P12883 1IK2 A V411I Disease P12883 1IK2 A V440M Disease P12883 1IK2 A V606M Disease P12883 1IK2 A V698A Disease P12883 1IK2 A V763G Disease P12883 1IK2 A V763M Disease P12883 1IK2 A V824I Disease P12883 1IK2 A Y115H Disease P12883 1IK2 A Y162C Disease P12883 1IK2 A Y501C Disease P12883 2FXM A A901G Disease P12883 2FXM A C905F Disease P12883 2FXM A D906G Disease P12883 2FXM A D928N Disease P12883 2FXM A D953H Disease P12883 2FXM A E846Q Disease P12883 2FXM A E894G Disease P12883 2FXM A E921K Disease P12883 2FXM A E924K Disease P12883 2FXM A E924Q Disease P12883 2FXM A E927K Disease P12883 2FXM A E930K Disease P12883 2FXM A E931K Disease P12883 2FXM A E935K Disease P12883 2FXM A E949K Disease P12883 2FXM A L908V Disease P12883 2FXM A M852T Disease P12883 2FXM A M877K Disease P12883 2FXM A Q882E Disease P12883 2FXM A R858C Disease P12883 2FXM A R858H Disease P12883 2FXM A R869C Disease P12883 2FXM A R869G Disease P12883 2FXM A R869H Disease P12883 2FXM A R870C Disease P12883 2FXM A R870H Disease P12931 1O43 A A93T Neutral P12931 1O43 A F32L *Neutral P12931 1O43 A L32F Neutral P12931 1O43 A T93A *Neutral P13236 1HUM A S57T Neutral P13236 1HUM A T57S *Neutral P13489 1Z7X W L169P *Neutral P13489 1Z7X W P169L Neutral P13501 1HRJ A F1S *Neutral P13501 1HRJ A S1F Neutral P13686 2BQ8 X I200V *Neutral P13686 2BQ8 X M127V *Neutral P13686 2BQ8 X M179V *Neutral P13686 2BQ8 X V127M Neutral P13686 2BQ8 X V179M Neutral P13686 2BQ8 X V200I Neutral P13726 1BOY A A4T *Neutral P13726 1BOY A T4A Neutral P13726 1UJ3 C I713V Neutral P13726 1UJ3 C R731W Neutral P13726 1UJ3 C V713I *Neutral P13726 1UJ3 C W731R *Neutral P13746 1X7Q A D77N Neutral P13746 1X7Q A G65R *Neutral P13746 1X7Q A N77D *Neutral P13746 1X7Q A R65G Neutral P13746 1X7Q A A152E Neutral P13746 1X7Q A E144K *Neutral P13746 1X7Q A E152A *Neutral P13746 1X7Q A F109L Neutral P13746 1X7Q A G107W Neutral P13746 1X7Q A H145R *Neutral P13746 1X7Q A H181R *Neutral P13746 1X7Q A I142T Neutral P13746 1X7Q A K127N *Neutral P13746 1X7Q A K144E Neutral P13746 1X7Q A L109F *Neutral P13746 1X7Q A N127K Neutral P13746 1X7Q A R145H Neutral P13746 1X7Q A R181H Neutral P13746 1X7Q A T142I *Neutral P13746 1X7Q A W107G *Neutral P13747 3BZE A G83R Neutral P13747 3BZE A K77N *Neutral P13747 3BZE A N77K Neutral P13747 3BZE A R83G *Neutral P13747 3BZE A G107R *Neutral P13747 3BZE A G157R *Neutral P13747 3BZE A R107G Neutral P13747 3BZE A R157G Neutral P13765 1A6A B F26Y *Neutral P13765 1A6A B Y26F Neutral P13765 1A6A B G135S Neutral P13765 1A6A B S135G *Neutral P13765 1FV1 B Q4R *Neutral P13765 1FV1 B R4Q Neutral P13765 1FV1 B N77T *Neutral P13765 1FV1 B T77N Neutral P13765 1KLU B Q4R *Neutral P13765 1KLU B R4Q Neutral P13765 1KLU B A73G Neutral P13765 1KLU B D70Q *Neutral P13765 1KLU B G73A *Neutral P13765 1KLU B N77T *Neutral P13765 1KLU B Q70D Neutral P13765 1KLU B S37Y Neutral P13765 1KLU B S60Y *Neutral P13765 1KLU B T77N Neutral P13765 1KLU B Y37S *Neutral P13765 1KLU B Y60S Neutral P13765 1KLU B A140T Neutral P13765 1KLU B D135G *Neutral P13765 1KLU B G135D Neutral P13765 1KLU B H149Q *Neutral P13765 1KLU B M142V *Neutral P13765 1KLU B Q149H Neutral P13765 1KLU B Q166R *Neutral P13765 1KLU B R166Q Neutral P13765 1KLU B T140A *Neutral P13765 1KLU B V142M Neutral P13765 2Q6W B A85V *Neutral P13765 2Q6W B C11R *Neutral P13765 2Q6W B R11C Neutral P13765 2Q6W B V85A Neutral P13765 2WBJ F F26Y Neutral P13765 2WBJ F H30Y *Neutral P13765 2WBJ F N77T *Neutral P13765 2WBJ F T77N Neutral P13765 2WBJ F Y26F *Neutral P13765 2WBJ F Y30H Neutral P13765 2WBJ F G135S Neutral P13765 2WBJ F S135G *Neutral P13804 1EFV A G116R Disease P13804 1EFV A I171T *Neutral P13804 1EFV A T171I Neutral P13804 1EFV A T266M Disease P13804 1EFV A V157G Disease P13945 2CDW A R64W *Neutral P13945 2CDW A W64R Neutral P13945 2CDW A E249K Neutral P13945 2CDW A K249E *Neutral P14061 1I5R A A237V Neutral P14061 1I5R A V237A *Neutral P14091 1QRP E A203T Neutral P14091 1QRP E D314E Neutral P14091 1QRP E E314D *Neutral P14091 1QRP E K160Q *Neutral P14091 1QRP E L291V Neutral P14091 1QRP E Q160K Neutral P14091 1QRP E T203A *Neutral P14091 1QRP E V291L *Neutral P14151 3CFW A F155L Neutral P14151 3CFW A L155F *Neutral P14210 2QJ2 B I1153S *Neutral P14210 2QJ2 B S1153I Neutral P14324 2F94 F I325V Neutral P14324 2F94 F V325I *Neutral P14598 1NG2 A A308V Neutral P14598 1NG2 A D166N Neutral P14598 1NG2 A E258K *Neutral P14598 1NG2 A G262S Neutral P14598 1NG2 A K258E Neutral P14598 1NG2 A N166D *Neutral P14598 1NG2 A S160T *Neutral P14598 1NG2 A S262G *Neutral P14598 1NG2 A T160S Neutral P14598 1NG2 A V308A *Neutral P14618 3GR4 A G204V Neutral P14618 3GR4 A V204G *Neutral P14678 1D3B L P79S *Neutral P14678 1D3B L S79P Neutral P14778 1ITB B A107G Neutral P14778 1ITB B G107A *Neutral P14784 1ILM B F57S *Neutral P14784 1ILM B S57F Neutral P15085 2V77 A A98T Neutral P15085 2V77 A T98A *Neutral P15085 2V77 A H166R Neutral P15085 2V77 A R166H *Neutral P15104 2QC8 A R324C Disease P15104 2QC8 A R341C Disease P15121 1ADS A F14I *Neutral P15121 1ADS A I14F Neutral P15121 1ADS A L72V Neutral P15121 1ADS A V72L *Neutral P15121 1ADS A G203S Neutral P15121 1ADS A I287T *Neutral P15121 1ADS A S203G *Neutral P15121 1ADS A T287I Neutral P15153 1DS6 A D57N Disease P15309 1ND6 B F1091V Neutral P15309 1ND6 B H1297Y *Neutral P15309 1ND6 B R1193W *Neutral P15309 1ND6 B V1091F *Neutral P15309 1ND6 B W1193R Neutral P15309 1ND6 B Y1297H Neutral P15311 1NI2 A C180R *Neutral P15311 1NI2 A R180C Neutral P15529 1HR4 A P7S Disease P15529 1HR4 A S82P Disease P15529 1HR4 A D108N Neutral P15529 1HR4 A N108D *Neutral P15529 2O39 C Q25R *Neutral P15529 2O39 C R25Q Neutral P15559 1D4A A H268Q *Neutral P15559 1D4A A P186S Neutral P15559 1D4A A Q268H Neutral P15559 1D4A A R138W Neutral P15559 1D4A A S186P *Neutral P15559 1D4A A W138R *Neutral P15559 1SG0 A D57G *Neutral P15559 1SG0 A E28G Neutral P15559 1SG0 A F46L Neutral P15559 1SG0 A G28E *Neutral P15559 1SG0 A G57D Neutral P15559 1SG0 A L46F *Neutral P15559 1SG0 A A183V *Neutral P15559 1SG0 A V183A Neutral P15813 1ZT4 C S46T *Neutral P15813 1ZT4 C T46S Neutral P15814 2H3N B L83P *Neutral P15814 2H3N B P83L Neutral P15814 2H3N B H152R *Neutral P15814 2H3N B P105L Disease P15814 2H3N B R152H Neutral P15882 2OSA A E313K Disease P15927 1DPU A N203S Neutral P15927 1DPU A S203N *Neutral P16050 2ABT A D89H Neutral P16050 2ABT A H89D *Neutral P16050 2ABT A M559T *Neutral P16050 2ABT A T559M Neutral P16083 1SG0 A K15R Neutral P16083 1SG0 A R15K *Neutral P16109 1FSB A G20R Neutral P16109 1FSB A R20G *Neutral P16144 3F7Q A H1216Q Neutral P16144 3F7Q A Q1216H *Neutral P16144 3F7Q A R1225H Disease P16144 3F7Q A R1281W Disease P16152 1WMA A I87V *Neutral P16152 1WMA A V87I Neutral P16401 2FE2 A A210T Neutral P16401 2FE2 A K143R Neutral P16401 2FE2 A R143K *Neutral P16401 2FE2 A T210A *Neutral P16435 1B1C A L165P *Neutral P16435 1B1C A P165L Neutral P16435 1B1C A Y118D Disease P16473 3G04 C C41S Disease P16473 3G04 C E34K Neutral P16473 3G04 C K34E *Neutral P16473 3G04 C P52T Neutral P16473 3G04 C T52P *Neutral P16473 3G04 C D219E Disease P16473 3G04 C F197I Disease P16473 3G04 C I167N Disease P16473 3G04 C K183R Disease P16473 3G04 C L252P Disease P16473 3G04 C P162A Disease P16473 3G04 C R109Q Disease P16581 1G1T A I10M *Neutral P16581 1G1T A M10I Neutral P16581 1G1T A C109W Neutral P16581 1G1T A R128S *Neutral P16581 1G1T A S128R Neutral P16581 1G1T A W109C *Neutral P17540 3B6R A F360L *Neutral P17540 3B6R A L360F Neutral P17900 1PUB A I28V Neutral P17900 1PUB A M38V Neutral P17900 1PUB A V28I *Neutral P17900 1PUB A V38M *Neutral P17900 1PUB A C107R Disease P17900 1PUB A R138P Disease P17931 2NMO A K183R *Neutral P17931 2NMO A R183K Neutral P17948 1FLT X E144K Neutral P17948 1FLT X K144E *Neutral P18084 1TYE B I427V *Neutral P18084 1TYE B V427I Neutral P18085 1Z6X A A68V *Neutral P18085 1Z6X A V68A Neutral P18206 1RKC A L234V *Neutral P18206 1RKC A V234L Neutral P18440 2DSS _ D251V Neutral P18440 2DSS _ E261K Neutral P18440 2DSS _ I263V Neutral P18440 2DSS _ K261E *Neutral P18440 2DSS _ M205V Neutral P18440 2DSS _ Q187R *Neutral P18440 2DSS _ R117T Neutral P18440 2DSS _ R187Q Neutral P18440 2DSS _ T117R *Neutral P18440 2DSS _ V205M *Neutral P18440 2DSS _ V251D *Neutral P18440 2DSS _ V263I *Neutral P18464 1E27 A D156L *Neutral P18464 1E27 A E152V Neutral P18464 1E27 A G167W *Neutral P18464 1E27 A H171Y Neutral P18464 1E27 A L156D Neutral P18464 1E27 A R131S *Neutral P18464 1E27 A S131R Neutral P18464 1E27 A V152E *Neutral P18464 1E27 A W167G Neutral P18464 1E27 A Y171H *Neutral P18465 2RFX A H113Y Neutral P18465 2RFX A S116Y Neutral P18465 2RFX A Y113H *Neutral P18465 2RFX A Y116S *Neutral P18564 1LH9 A P367T Neutral P18564 1LH9 A T367P *Neutral P18848 1CI6 A D322E *Neutral P18848 1CI6 A E322D Neutral P18887 1CDZ A Q22R *Neutral P18887 1CDZ A R22Q Neutral P18887 1CDZ A R23W Neutral P18887 1CDZ A S39Y *Neutral P18887 1CDZ A W23R *Neutral P18887 1CDZ A Y39S Neutral P18887 1XNA A L7R *Neutral P18887 1XNA A R7L Neutral P18887 1XNA A A72V *Neutral P18887 1XNA A M10V *Neutral P18887 1XNA A V10M Neutral P18887 1XNA A V72A Neutral P18887 1XNA A H107R *Neutral P18887 1XNA A R107H Neutral P19367 1HKB A L529S Disease P19367 1HKB A T680S Disease P19438 1EXT A C30R Disease P19438 1EXT A C30S Disease P19438 1EXT A C33G Disease P19438 1EXT A C33Y Disease P19438 1EXT A C52F Disease P19438 1EXT A C70S Disease P19438 1EXT A C88R Disease P19438 1EXT A C88Y Disease P19438 1EXT A H22Q Disease P19438 1EXT A P46L Disease P19438 1EXT A R92P Disease P19438 1EXT A R92Q Disease P19438 1EXT A S86G Disease P19438 1EXT A T50M Disease P19544 1LU6 A C329Y Disease P19544 1LU6 A C354G Disease P19544 1LU6 A C354Y Disease P19544 1LU6 A C359G Disease P19544 1LU6 A C359Y Disease P19544 1LU6 A C384R Disease P19544 1LU6 A C387F Disease P19544 1LU6 A C387Y Disease P19544 1LU6 A D395G Disease P19544 1LU6 A D395N Disease P19544 1LU6 A D395Y Disease P19544 1LU6 A F382L Disease P19544 1LU6 A F391L Disease P19544 1LU6 A H372Q Disease P19544 1LU6 A H372Y Disease P19544 1LU6 A H376R Disease P19544 1LU6 A H376Y Disease P19544 1LU6 A H400Y Disease P19544 1LU6 A H404R Disease P19544 1LU6 A L397P Disease P19544 1LU6 A M341R Disease P19544 1LU6 A Q368P Disease P19544 1LU6 A R311Q Disease P19544 1LU6 A R365C Disease P19544 1LU6 A R365H Disease P19544 1LU6 A R365L Disease P19544 1LU6 A R393L Disease P19544 1LU6 A R393P Disease P19544 1LU6 A R393Q Disease P19544 1LU6 A R393W Disease P19623 2O07 B L149V Neutral P19623 2O07 B V149L *Neutral P19784 3E3B X A188E *Neutral P19784 3E3B X E188A Neutral P19793 1G5Y B A327S Neutral P19793 1G5Y B I336S *Neutral P19793 1G5Y B S327A *Neutral P19793 1G5Y B S336I Neutral P19878 1E96 B G78E Disease P19878 1E96 B R77Q Disease P19878 1E96 B A128V Disease P19878 1E96 B K181R Neutral P19878 1E96 B R181K *Neutral P19971 2WK6 A R44Q Disease P19971 2WK6 A E289A Disease P19971 2WK6 A G145R Disease P19971 2WK6 A G153S Disease P19971 2WK6 A K222R Disease P19971 2WK6 A L471S *Neutral P19971 2WK6 A S471L Neutral P20700 3HN9 A A501V Neutral P20700 3HN9 A V501A *Neutral P20701 1LFA A R189W Neutral P20701 1LFA A W189R *Neutral P20702 1N3Y A A232T Neutral P20702 1N3Y A T232A *Neutral P20718 1LXV A Q84R *Neutral P20718 1LXV A R84Q Neutral P20807 1Y9V A A54V Disease P20807 1Y9V A D57G Disease P20807 1Y9V A D57H Disease P20807 1Y9V A F83S Disease P20807 1Y9V A R50P Disease P20807 1Y9V A S96G Disease P20807 1Y9V A A150E Disease P20807 1Y9V A H126D Disease P20807 1Y9V A R100Q Disease P20807 1Y9V A R121Q Disease P20933 1APY A A78V Disease P20933 1APY A G37D Disease P20933 1APY A G77E Disease P20933 1APY A S49P Disease P20933 1APY A C140S Disease P20933 1APY A F112S Disease P20933 1APY A R138Q Disease P20933 1APY A S126T Neutral P20933 1APY A T126S *Neutral P21266 1GUL A A163T *Neutral P21266 1GUL A T163A Neutral P21266 1K3Y A I19T *Neutral P21266 1K3Y A T19I Neutral P21266 1K3Y A K117Q Neutral P21266 1K3Y A Q117K *Neutral P21266 1XW6 A K172N Neutral P21266 1XW6 A N172K *Neutral P21266 2A2R A A113V Neutral P21266 2A2R A I104V Neutral P21266 2A2R A V104I *Neutral P21266 2A2R A V113A *Neutral P21266 3GTU B I223V *Neutral P21266 3GTU B V223I Neutral P21266 4GTU A A159V Neutral P21266 4GTU A K210R *Neutral P21266 4GTU A R210K Neutral P21266 4GTU A V159A *Neutral P21359 2D4Q A A1764S Disease P21359 2D4Q A I1584V Disease P21359 2D4Q A R1590W Disease P21397 2Z5X A F314V Neutral P21397 2Z5X A K520R Neutral P21397 2Z5X A R520K *Neutral P21397 2Z5X A V314F *Neutral P21399 2B3Y A A395D Neutral P21399 2B3Y A D395A *Neutral P21399 2B3Y A G486R Neutral P21399 2B3Y A R486G *Neutral P21583 1EXZ B A229T *Neutral P21583 1EXZ B T229A Neutral P21675 1EQF A I1383V *Neutral P21675 1EQF A V1383I Neutral P21728 1OZ5 A P37T *Neutral P21728 1OZ5 A R37T *Neutral P21728 1OZ5 A R50S Neutral P21728 1OZ5 A S50R *Neutral P21728 1OZ5 A T37P Neutral P21728 1OZ5 A T37R Neutral P21728 1OZ5 A A199S *Neutral P21728 1OZ5 A S199A Neutral P21731 1LBN A A160T Neutral P21731 1LBN A E176V *Neutral P21731 1LBN A I217V *Neutral P21731 1LBN A T160A *Neutral P21731 1LBN A V176E Neutral P21731 1LBN A V217I Neutral P21802 3CAF A A172F Disease P21802 3CAF A M186T Neutral P21802 3CAF A T186M *Neutral P21953 1X7Y B G228S Disease P21953 1X7Y B H156R Disease P21953 1X7Y B R133P Disease P21964 3BWM A A22S Neutral P21964 3BWM A A52T Neutral P21964 3BWM A A96V Neutral P21964 3BWM A S22A *Neutral P21964 3BWM A T52A *Neutral P21964 3BWM A V96A *Neutral P21964 3BWM A M108V *Neutral P21964 3BWM A V108M Neutral P22004 2H62 A D105G Neutral P22004 2H62 A G105D *Neutral P22303 1PUV A A99P *Neutral P22303 1PUV A P99A Neutral P22303 1PUV A E297V *Neutral P22303 1PUV A H317N Neutral P22303 1PUV A N317H *Neutral P22303 1PUV A V297E Neutral P22607 1RY7 B E322K Disease P22607 1RY7 B M338T *Neutral P22607 1RY7 B P250R Disease P22607 1RY7 B R248C Disease P22607 1RY7 B S249C Disease P22607 1RY7 B T338M Neutral P22681 2JUJ A I54V *Neutral P22681 2JUJ A V54I Neutral P22692 1WQJ B G21V *Neutral P22692 1WQJ B V21G Neutral P22748 1ZNC A R193S Disease P22830 2QD4 A I71K Disease P22830 2QD4 A Q96R *Neutral P22830 2QD4 A R96Q Neutral P22830 2QD4 A C236Y Disease P22830 2QD4 A C406S Disease P22830 2QD4 A C406Y Disease P22830 2QD4 A E178K Disease P22830 2QD4 A F260L Disease P22830 2QD4 A F417S Disease P22830 2QD4 A H386P Disease P22830 2QD4 A I186T Disease P22830 2QD4 A K379N Disease P22830 2QD4 A L182R Disease P22830 2QD4 A M267I Disease P22830 2QD4 A M288K Disease P22830 2QD4 A P192T Disease P22830 2QD4 A P334L Disease P22830 2QD4 A Q139L Disease P22830 2QD4 A S151P Disease P22830 2QD4 A S264L Disease P22830 2QD4 A T283I Disease P22830 2QD4 A V362G Disease P22830 2QD4 A Y191H Disease P22888 1LUT A C131R Disease P22894 1I76 A E134G *Neutral P22894 1I76 A G134E Neutral P23025 1XPA A C108F Disease P23025 1XPA A Q185H Disease P23025 1XPA A R130K Disease P23284 1CYN A L28V *Neutral P23284 1CYN A V28L Neutral P23467 2AHS A A1934G *Neutral P23467 2AHS A G1934A Neutral P23526 1LI4 A A89V Disease P23526 1LI4 A D86G Disease P23526 1LI4 A D86N Neutral P23526 1LI4 A N86D *Neutral P23526 1LI4 A R38W Neutral P23526 1LI4 A R49C Disease P23526 1LI4 A W38R *Neutral P23526 1LI4 A Y143C Disease P23945 1XWD C A189V Disease P23945 1XWD C D224V Disease P23945 1XWD C I160T Disease P23945 1XWD C S128Y Disease P24071 1OW0 C D92N Neutral P24071 1OW0 C N92D *Neutral P24666 5PNT A K6N Neutral P24666 5PNT A N6K *Neutral P24666 5PNT A F136S *Neutral P24666 5PNT A Q105R Neutral P24666 5PNT A R105Q *Neutral P24666 5PNT A S136F Neutral P24752 2IB8 D N93S Disease P24752 2IB8 D A301P Disease P24752 2IB8 D A333P Disease P24752 2IB8 D A380T Disease P24752 2IB8 D G152A Disease P24752 2IB8 D G183R Disease P24752 2IB8 D G379V Disease P24752 2IB8 D I312T Disease P24752 2IB8 D N158D Disease P24752 2IB8 D T297M Disease P24821 1TEN A D850H Neutral P24821 1TEN A H850D *Neutral P24941 1YKR A L18V *Neutral P24941 1YKR A S15Y *Neutral P24941 1YKR A V18L Neutral P24941 1YKR A Y15S Neutral P24941 1YKR A S290T *Neutral P24941 1YKR A T290S Neutral P25105 2B0X A N338S Neutral P25105 2B0X A S338N *Neutral P25774 2H7J A S47T Neutral P25774 2H7J A T47S *Neutral P25774 2HHN A R-1W Neutral P25774 2HHN A W-1R *Neutral P25929 2IIL _ K374T Neutral P25929 2IIL _ T374K *Neutral P25942 1CDF A C26Q Disease P25942 1CDF A C83R Disease P25942 1CDF A S35G Disease P25942 1CDF A S39T Disease P25942 1CDF A L124S *Neutral P25942 1CDF A S124L Neutral P26378 1FXL A D159G Neutral P26378 1FXL A G159D *Neutral P26440 1IVH A D40N Disease P26440 1IVH A L13P Disease P26440 1IVH A R21P Disease P26440 1IVH A A282V Disease P26440 1IVH A C328R Disease P26440 1IVH A G170V Disease P26440 1IVH A R363C Disease P26440 1IVH A R382L Disease P26440 1IVH A V342A Disease P26678 1ZLL A R9C Disease P26718 1MPU A N177S Neutral P26718 1MPU A S177N *Neutral P27169 1XHR A L55M *Neutral P27169 1XHR A M55L Neutral P27169 1XHR A G160R *Neutral P27169 1XHR A I102V Neutral P27169 1XHR A Q192R Neutral P27169 1XHR A R160G Neutral P27169 1XHR A R192Q *Neutral P27169 1XHR A V102I *Neutral P27540 2A24 B E84K Neutral P27540 2A24 B K84E *Neutral P27540 2A24 B Q79R *Neutral P27540 2A24 B R79Q Neutral P27694 1JMC A A351T *Neutral P27694 1JMC A T351A Neutral P27695 1BIX A H51Q *Neutral P27695 1BIX A I64V Neutral P27695 1BIX A Q51H Neutral P27695 1BIX A V64I *Neutral P27695 1BIX A D148E Neutral P27695 1BIX A E148D *Neutral P27815 1LXU A Q39R *Neutral P27815 1LXU A R39Q Neutral P28067 1S9V A C44Y Neutral P28067 1S9V A D47V *Neutral P28067 1S9V A F15S *Neutral P28067 1S9V A I63M Neutral P28067 1S9V A L47V *Neutral P28067 1S9V A M63I *Neutral P28067 1S9V A R61T *Neutral P28067 1S9V A S15F Neutral P28067 1S9V A S23T *Neutral P28067 1S9V A S77Y Neutral P28067 1S9V A T23S Neutral P28067 1S9V A T61R Neutral P28067 1S9V A V47D Neutral P28067 1S9V A V47L Neutral P28067 1S9V A Y44C *Neutral P28067 1S9V A Y77S *Neutral P28067 1S9V A I104T Neutral P28067 1S9V A T104I *Neutral P28068 2BC4 D A10T *Neutral P28068 2BC4 D D31V Neutral P28068 2BC4 D F27S *Neutral P28068 2BC4 D N53S *Neutral P28068 2BC4 D S27F Neutral P28068 2BC4 D S53N Neutral P28068 2BC4 D T10A Neutral P28068 2BC4 D V31D *Neutral P28068 2BC4 D A144E Neutral P28068 2BC4 D A144V Neutral P28068 2BC4 D E144A *Neutral P28068 2BC4 D I179T Neutral P28068 2BC4 D T179I *Neutral P28068 2BC4 D V144A *Neutral P28161 1XW5 A N172S *Neutral P28161 1XW5 A S172N Neutral P28222 2G1X A C124F *Neutral P28222 2G1X A F124C Neutral P28676 1K94 A A80S *Neutral P28676 1K94 A S80A Neutral P28702 1G5Y B A398V Neutral P28702 1G5Y B L261P *Neutral P28702 1G5Y B P261L Neutral P28702 1G5Y B V398A *Neutral P28702 1NAX A D216G Neutral P28702 1NAX A G216D *Neutral P28702 1NAX A I337T *Neutral P28702 1NAX A T337I Neutral P29074 2B49 A D763N Neutral P29074 2B49 A N763D *Neutral P29084 1D8J A I68T Neutral P29084 1D8J A T68I *Neutral P29218 2HHM A I109V Neutral P29218 2HHM A V109I *Neutral P29317 3HEI A K72N Neutral P29317 3HEI A N72K *Neutral P29353 1WCP A M284V Neutral P29353 1WCP A V284M *Neutral P29965 1ALY A A123E Disease P29965 1ALY A A173D Disease P29965 1ALY A A208D Disease P29965 1ALY A A235P Disease P29965 1ALY A G116R Disease P29965 1ALY A G116S Disease P29965 1ALY A G144E Disease P29965 1ALY A G219R Neutral P29965 1ALY A G226A Disease P29965 1ALY A G227V Disease P29965 1ALY A G257D Disease P29965 1ALY A G257S Disease P29965 1ALY A H125R Disease P29965 1ALY A H224Y Disease P29965 1ALY A K143T Disease P29965 1ALY A L155P Disease P29965 1ALY A L195P Disease P29965 1ALY A L231S Disease P29965 1ALY A L258S Disease P29965 1ALY A Q174R Disease P29965 1ALY A R219G *Neutral P29965 1ALY A T147N Disease P29965 1ALY A T176I Disease P29965 1ALY A T211N Disease P29965 1ALY A T254M Disease P29965 1ALY A V126A Disease P29965 1ALY A V126D Disease P29965 1ALY A V237E Disease P29965 1ALY A W140C Disease P29965 1ALY A W140G Disease P29965 1ALY A W140R Disease P29965 1ALY A Y170C Disease P29972 1H6I A A45V Neutral P29972 1H6I A V45A *Neutral P30043 1HDO A Q46R *Neutral P30043 1HDO A R46Q Neutral P30086 1BEH A N9S *Neutral P30086 1BEH A S9N Neutral P30305 1QB0 A E534K Neutral P30305 1QB0 A K534E *Neutral P30443 3BO8 A F9S Neutral P30443 3BO8 A S9F *Neutral P30443 3BO8 A A90D *Neutral P30443 3BO8 A D90A Neutral P30443 3BO8 A I97M Neutral P30443 3BO8 A M97I *Neutral P30443 3BO8 A A158V *Neutral P30443 3BO8 A G107W Neutral P30443 3BO8 A K127N *Neutral P30443 3BO8 A L156R *Neutral P30443 3BO8 A N127K Neutral P30443 3BO8 A R156L Neutral P30443 3BO8 A V158A Neutral P30443 3BO8 A W107G *Neutral P30460 1AGD A D63N *Neutral P30460 1AGD A D74Y Neutral P30460 1AGD A N63D Neutral P30460 1AGD A Y74D *Neutral P30460 1AGD A D116Y *Neutral P30460 1AGD A E152V *Neutral P30460 1AGD A H113Y Neutral P30460 1AGD A R131S Neutral P30460 1AGD A S131R *Neutral P30460 1AGD A V152E Neutral P30460 1AGD A Y113H *Neutral P30460 1AGD A Y116D Neutral P30464 1XR9 A A24S Neutral P30464 1XR9 A E63N Neutral P30464 1XR9 A N63E *Neutral P30464 1XR9 A R97T Neutral P30464 1XR9 A S24A *Neutral P30464 1XR9 A S67Y Neutral P30464 1XR9 A T97R *Neutral P30464 1XR9 A Y67S *Neutral P30464 1XR9 A L156W *Neutral P30464 1XR9 A W156L Neutral P30481 1M6O A D116Y Neutral P30481 1M6O A D156L Neutral P30481 1M6O A L156D *Neutral P30481 1M6O A L163T Neutral P30481 1M6O A T163L *Neutral P30481 1M6O A Y116D *Neutral P30504 1QQD A S9Y Neutral P30504 1QQD A Y9S *Neutral P30504 1QQD A A49E *Neutral P30504 1QQD A E49A Neutral P30504 1QQD A G16S Neutral P30504 1QQD A H21R *Neutral P30504 1QQD A R14W *Neutral P30504 1QQD A R21H Neutral P30504 1QQD A S16G *Neutral P30504 1QQD A W14R Neutral P30504 1QQD A A158V Neutral P30504 1QQD A V158A *Neutral P30530 2C5D C M105T *Neutral P30530 2C5D C T105M Neutral P30533 1LRE A N80S Neutral P30533 1LRE A S80N *Neutral P30533 2FTU A M72V *Neutral P30533 2FTU A V72M Neutral P30556 1ZV0 B L48V Neutral P30556 1ZV0 B V48L *Neutral P30556 1ZV0 B C289W Neutral P30556 1ZV0 B P336T *Neutral P30556 1ZV0 B T282M Disease P30556 1ZV0 B T336P Neutral P30556 1ZV0 B W289C *Neutral P30613 2VGB A G95R Disease P30613 2VGB A I90N Disease P30613 2VGB A L73P Disease P30613 2VGB A R86P Disease P30613 2VGB A S80P Disease P30613 2VGB A A115P Disease P30613 2VGB A A154T Disease P30613 2VGB A A295V Disease P30613 2VGB A A336S Disease P30613 2VGB A A352D Disease P30613 2VGB A A392T Disease P30613 2VGB A A394D Disease P30613 2VGB A A394V Disease P30613 2VGB A A431T Disease P30613 2VGB A A459V Disease P30613 2VGB A A468G Disease P30613 2VGB A A468V Disease P30613 2VGB A A495T Disease P30613 2VGB A A495V Disease P30613 2VGB A D281N Disease P30613 2VGB A D293N Disease P30613 2VGB A D331E Disease P30613 2VGB A D331N Disease P30613 2VGB A D339H Disease P30613 2VGB A D390N Disease P30613 2VGB A E172Q Disease P30613 2VGB A E315K Disease P30613 2VGB A E387G Disease P30613 2VGB A E427A Disease P30613 2VGB A E427D Disease P30613 2VGB A F287V Disease P30613 2VGB A G111R Disease P30613 2VGB A G159V Disease P30613 2VGB A G165V Disease P30613 2VGB A G222A Disease P30613 2VGB A G263R Disease P30613 2VGB A G263W Disease P30613 2VGB A G275R Disease P30613 2VGB A G332S Disease P30613 2VGB A G341A Disease P30613 2VGB A G341D Disease P30613 2VGB A G358E Disease P30613 2VGB A G364D Disease P30613 2VGB A G458D Disease P30613 2VGB A G511R Disease P30613 2VGB A G557A Disease P30613 2VGB A I153T Disease P30613 2VGB A I219T Disease P30613 2VGB A I310N Disease P30613 2VGB A I314T Disease P30613 2VGB A I342F Disease P30613 2VGB A I357T Disease P30613 2VGB A I506V *Neutral P30613 2VGB A K348N Disease P30613 2VGB A L155P Disease P30613 2VGB A L272V Disease P30613 2VGB A L374P Disease P30613 2VGB A M107T Disease P30613 2VGB A N361D Disease P30613 2VGB A N393K Disease P30613 2VGB A N393S Disease P30613 2VGB A N566K Disease P30613 2VGB A Q421K Disease P30613 2VGB A R163C Disease P30613 2VGB A R163L Disease P30613 2VGB A R337P Disease P30613 2VGB A R337Q Disease P30613 2VGB A R359C Disease P30613 2VGB A R359H Disease P30613 2VGB A R385W Disease P30613 2VGB A R426Q Disease P30613 2VGB A R426W Disease P30613 2VGB A R479H Disease P30613 2VGB A R486W Disease P30613 2VGB A R488Q Disease P30613 2VGB A R490W Disease P30613 2VGB A R498C Disease P30613 2VGB A R498H Disease P30613 2VGB A R504L Disease P30613 2VGB A R510Q Disease P30613 2VGB A R531C Disease P30613 2VGB A R532Q Disease P30613 2VGB A R532W Disease P30613 2VGB A R559G Disease P30613 2VGB A R569Q Disease P30613 2VGB A S120F Disease P30613 2VGB A S130Y Disease P30613 2VGB A S376I Disease P30613 2VGB A S485F Disease P30613 2VGB A T384M Disease P30613 2VGB A T408A Disease P30613 2VGB A T408I Disease P30613 2VGB A T477A Disease P30613 2VGB A V134D Disease P30613 2VGB A V288L Disease P30613 2VGB A V320L Disease P30613 2VGB A V335M Disease P30613 2VGB A V368F Disease P30613 2VGB A V460M Disease P30613 2VGB A V506I Neutral P30613 2VGB A V552M Disease P30685 1XH3 A A24S Neutral P30685 1XH3 A E45T *Neutral P30685 1XH3 A E63N *Neutral P30685 1XH3 A N63E Neutral P30685 1XH3 A S24A *Neutral P30685 1XH3 A T45E Neutral P30685 1XH3 A D114N Neutral P30685 1XH3 A F109L *Neutral P30685 1XH3 A F116S *Neutral P30685 1XH3 A L109F Neutral P30685 1XH3 A N114D *Neutral P30685 1XH3 A S116F Neutral P30711 2C3N A D141N Neutral P30711 2C3N A I169V *Neutral P30711 2C3N A N141D *Neutral P30711 2C3N A V169I Neutral P30793 1FB1 A A74V Disease P30793 1FB1 A G83A Disease P30793 1FB1 A G90V Disease P30793 1FB1 A L71Q Disease P30793 1FB1 A L79P Disease P30793 1FB1 A R88P Disease P30793 1FB1 A R88W Disease P30793 1FB1 A C141R Disease P30793 1FB1 A C141W Disease P30793 1FB1 A D115N Disease P30793 1FB1 A D134V Disease P30793 1FB1 A F234S Disease P30793 1FB1 A G108D Disease P30793 1FB1 A G201E Disease P30793 1FB1 A G203R Disease P30793 1FB1 A H144P Disease P30793 1FB1 A H153P Disease P30793 1FB1 A I135K Disease P30793 1FB1 A K224R Disease P30793 1FB1 A L163R Disease P30793 1FB1 A M102K Disease P30793 1FB1 A M102R Disease P30793 1FB1 A M211I Disease P30793 1FB1 A M211V Disease P30793 1FB1 A M213V Disease P30793 1FB1 A M221T Disease P30793 1FB1 A P199L Disease P30793 1FB1 A Q180R Disease P30793 1FB1 A R178S Disease P30793 1FB1 A R184H Disease P30793 1FB1 A R241W Disease P30793 1FB1 A R249S Disease P30793 1FB1 A S176T Disease P30793 1FB1 A T106I Disease P30793 1FB1 A T186K Disease P30793 1FB1 A V191I Disease P30988 3C5T A H44R *Neutral P30988 3C5T A R44H Neutral P30988 3C5T A Q131R *Neutral P30988 3C5T A R131Q Neutral P31371 1IHK A I94V Neutral P31371 1IHK A V94I *Neutral P31749 1UNP A E17K Disease P31785 1ILL G C6G Disease P31785 1ILL G C59F Disease P31785 1ILL G C59R Disease P31785 1ILL G E12G Disease P31785 1ILL G E12K Disease P31785 1ILL G E53K Neutral P31785 1ILL G G58D Disease P31785 1ILL G H67P Disease P31785 1ILL G I97N Disease P31785 1ILL G K53E *Neutral P31785 1ILL G N28K Disease P31785 1ILL G Q88P Disease P31785 1ILL G Y33C Disease P31785 1ILL G Y49C Disease P31785 1ILL G Y69N Disease P31785 1ILL G A100V Disease P31785 1ILL G C126R Disease P31785 1ILL G C175Y Disease P31785 1ILL G F171C Disease P31785 1ILL G G176R Disease P31785 1ILL G L106H Disease P31785 1ILL G L116P Disease P31785 1ILL G L116Q Disease P31785 1ILL G L127S Disease P31785 1ILL G L174P Disease P31785 1ILL G R166C Disease P31785 1ILL G R168W Disease P31785 1ILL G R170C Disease P31785 1ILL G R170H Disease P31785 1ILL G S185I Disease P31785 1ILL G W184C Disease P31939 1PKX B K426R Disease P31939 1PKX B S116T *Neutral P31939 1PKX B T116S Neutral P32929 3COG D I67T *Neutral P32929 3COG D T67I Neutral P32942 1IC1 A C7S *Neutral P32942 1IC1 A S7C Neutral P32942 1IC1 A K29M Neutral P32942 1IC1 A M29K *Neutral P33763 2KAX A D54G Neutral P33763 2KAX A G54D *Neutral P33765 1OEA A K266M *Neutral P33765 1OEA A M266K Neutral P34913 1ZD3 A A21G *Neutral P34913 1ZD3 A G21A Neutral P34913 1ZD3 A K55R Neutral P34913 1ZD3 A Q52R *Neutral P34913 1ZD3 A R52Q Neutral P34913 1ZD3 A R55K *Neutral P34913 1ZD3 A C103R *Neutral P34913 1ZD3 A C154Y Neutral P34913 1ZD3 A E469G Neutral P34913 1ZD3 A G469E *Neutral P34913 1ZD3 A L223P *Neutral P34913 1ZD3 A M367V Neutral P34913 1ZD3 A P223L Neutral P34913 1ZD3 A Q285R *Neutral P34913 1ZD3 A R103C Neutral P34913 1ZD3 A R285Q Neutral P34913 1ZD3 A V367M *Neutral P34913 1ZD3 A Y154C *Neutral P35225 1J9U A Q110R *Neutral P35225 1J9U A R110Q Neutral P35226 2H0D A C18Y Neutral P35226 2H0D A Y18C *Neutral P35228 3E7G C R221W Neutral P35228 3E7G C W221R *Neutral P35232 1LU7 A V88A Disease P35232 1LU7 A R105H Disease P35240 1H4R A F62S Disease P35240 1H4R A M77V Disease P35240 1H4R A E106G Disease P35240 1H4R A G197C Disease P35240 1H4R A I273F Disease P35240 1H4R A L141P Disease P35240 1H4R A L234R Disease P35240 1H4R A N220Y Disease P35247 1PWB A E289K Neutral P35247 1PWB A K289E *Neutral P35247 1PWB A S270T Neutral P35247 1PWB A T270S *Neutral P35354 1V0X A A428P *Neutral P35354 1V0X A A511V *Neutral P35354 1V0X A E488G Neutral P35354 1V0X A G488E *Neutral P35354 1V0X A G587R Neutral P35354 1V0X A H228R *Neutral P35354 1V0X A P428A Neutral P35354 1V0X A R228H Neutral P35354 1V0X A R587G *Neutral P35354 1V0X A V511A Neutral P35475 1Y24 A A75T Disease P35475 1Y24 A A79V Disease P35475 1Y24 A G51D Disease P35475 1Y24 A H82P Disease P35475 1Y24 A R89Q Disease P35475 1Y24 A R89W Disease P35475 1Y24 A A279V *Neutral P35475 1Y24 A A327P Disease P35475 1Y24 A A361T Neutral P35475 1Y24 A D349N Disease P35475 1Y24 A D349Y Disease P35475 1Y24 A E182K Disease P35475 1Y24 A G116R Neutral P35475 1Y24 A G208D Disease P35475 1Y24 A G409R Disease P35475 1Y24 A I454V *Neutral P35475 1Y24 A L218P Disease P35475 1Y24 A L238Q Disease P35475 1Y24 A L346R Disease P35475 1Y24 A L490P Disease P35475 1Y24 A M133I Disease P35475 1Y24 A M504T Disease P35475 1Y24 A N350I Disease P35475 1Y24 A P496L Disease P35475 1Y24 A Q105R *Neutral P35475 1Y24 A Q380R Disease P35475 1Y24 A R105Q Neutral P35475 1Y24 A R116G *Neutral P35475 1Y24 A R363C Disease P35475 1Y24 A R383H Disease P35475 1Y24 A R489P Disease P35475 1Y24 A R492P Disease P35475 1Y24 A S260F Disease P35475 1Y24 A S423R Disease P35475 1Y24 A T361A *Neutral P35475 1Y24 A T366P Disease P35475 1Y24 A T388R Disease P35475 1Y24 A V279A Neutral P35475 1Y24 A V454I Neutral P35555 1EMN A A2160P Disease P35555 1EMN A C2142Y Disease P35555 1EMN A C2151W Disease P35555 1EMN A D2127E Disease P35555 1EMN A N2144S Disease P35555 1EMN A P2154R Disease P35555 1LMJ A C8R Disease P35555 1LMJ A D6G Disease P35555 1LMJ A E7K Disease P35555 1LMJ A C20W Disease P35555 1LMJ A C51G Disease P35555 1LMJ A C51Y Disease P35555 1LMJ A C63Y Disease P35555 1LMJ A C87S Disease P35555 1LMJ A C87Y Disease P35555 1LMJ A D47V Disease P35555 1LMJ A N65Y Disease P35555 1LMJ A R71P Disease P35555 1LMJ A Y35C Disease P35555 1UZJ A C1513R Disease P35555 1UZJ A C1564F Disease P35555 1UZJ A C1564Y Disease P35555 1UZJ A C1589F Disease P35555 1UZJ A C1610G Disease P35555 1UZJ A C1631G Disease P35555 1UZJ A M1576T Disease P35555 1UZJ A R1530C Disease P35556 1EMN A C2170F Neutral P35556 1EMN A F2170C *Neutral P35556 1LMJ A A82P *Neutral P35556 1LMJ A D47G Neutral P35556 1LMJ A G47D *Neutral P35556 1LMJ A P82A Neutral P35557 1GLK A A11T Neutral P35557 1GLK A A53S Disease P35557 1GLK A E70K Disease P35557 1GLK A G80A Disease P35557 1GLK A G80S Disease P35557 1GLK A R36W Disease P35557 1GLK A T11A *Neutral P35557 1GLK A A119D Disease P35557 1GLK A A188T Disease P35557 1GLK A A259T Disease P35557 1GLK A A384T Disease P35557 1GLK A C213R Disease P35557 1GLK A C382Y Disease P35557 1GLK A E221K Disease P35557 1GLK A E256K Disease P35557 1GLK A E279Q Disease P35557 1GLK A E300K Disease P35557 1GLK A E300Q Disease P35557 1GLK A F150S Disease P35557 1GLK A G175R Disease P35557 1GLK A G227C Disease P35557 1GLK A G261E Disease P35557 1GLK A G261R Disease P35557 1GLK A G299R Disease P35557 1GLK A G385V Disease P35557 1GLK A H137R Disease P35557 1GLK A I110T Disease P35557 1GLK A K414E Disease P35557 1GLK A L164P Disease P35557 1GLK A L309P Disease P35557 1GLK A M107T Neutral P35557 1GLK A M210K Disease P35557 1GLK A M210T Disease P35557 1GLK A R392C Disease P35557 1GLK A S131P Disease P35557 1GLK A S336L Disease P35557 1GLK A T107M *Neutral P35557 1GLK A T168P Disease P35557 1GLK A T209M Disease P35557 1GLK A T228M Disease P35557 1GLK A V182M Disease P35557 1GLK A V203A Disease P35557 1GLK A V226M Disease P35557 1GLK A V367M Disease P35557 1GLK A V455M Disease P35557 1GLK A W257R Disease P35557 1GLK A Y108H Disease P35659 2JX3 A A63V *Neutral P35659 2JX3 A V63A Neutral P35754 1JHB A D47Y Neutral P35754 1JHB A Y47D *Neutral P35914 2CW6 A D42E Disease P35914 2CW6 A D42G Disease P35914 2CW6 A D42H Disease P35914 2CW6 A E37K Disease P35914 2CW6 A K48N Disease P35914 2CW6 A R41Q Disease P35914 2CW6 A S75R Disease P35914 2CW6 A V70L Disease P35914 2CW6 A C174Y Disease P35914 2CW6 A D204N Disease P35914 2CW6 A E279K Disease P35914 2CW6 A F192S Disease P35914 2CW6 A G203E Disease P35914 2CW6 A H233R Disease P35914 2CW6 A I200F Disease P35914 2CW6 A L263P Disease P35914 2CW6 A S142F Disease P35914 2CW6 A S201Y Disease P36222 1HJX A I311T Neutral P36222 1HJX A T311I *Neutral P36551 2AEX A C352R *Neutral P36551 2AEX A E201K Disease P36551 2AEX A G189S Disease P36551 2AEX A G197W Disease P36551 2AEX A G279R Disease P36551 2AEX A G280R Disease P36551 2AEX A H272N *Neutral P36551 2AEX A H295D Disease P36551 2AEX A I294V *Neutral P36551 2AEX A K404E Disease P36551 2AEX A L214R Disease P36551 2AEX A N272H Neutral P36551 2AEX A P249R Disease P36551 2AEX A P249S Disease P36551 2AEX A R328C Disease P36551 2AEX A R331W Disease P36551 2AEX A R352C Neutral P36551 2AEX A R447C Disease P36551 2AEX A S208F Disease P36551 2AEX A V135A Disease P36551 2AEX A V294I Neutral P36551 2AEX A W427R Disease P36639 1IRY A M83V *Neutral P36639 1IRY A V83M Neutral P36873 1JK7 A F152S Neutral P36873 1JK7 A S152F *Neutral P36894 2H62 C C59Y Disease P36894 2H62 C Y39D Disease P36894 2H62 C C101R Disease P36894 2H62 C C107R Disease P36897 1PY5 A C291Y *Neutral P36897 1PY5 A D400G Disease P36897 1PY5 A K232E Disease P36897 1PY5 A M318R Disease P36897 1PY5 A R487P Disease P36897 1PY5 A R487Q Disease P36897 1PY5 A R487W Disease P36897 1PY5 A S241L Disease P36897 1PY5 A T200I Disease P36897 1PY5 A Y291C Neutral P36969 2OBI A A93T Disease P37198 2H4D A A233S Neutral P37198 2H4D A G139S Neutral P37198 2H4D A Q391P Disease P37198 2H4D A S139G *Neutral P37198 2H4D A S233A *Neutral P37198 2H4D A S283T Neutral P37198 2H4D A T283S *Neutral P37231 1ZGY A F360L Disease P37231 1ZGY A Q286P Disease P37231 1ZGY A R288H Disease P37231 1ZGY A R397C Disease P37840 1XQ8 A A30P Disease P37840 1XQ8 A A53T Disease P37840 1XQ8 A E46K Disease P38117 1EFV B D128N Disease P38117 1EFV B M154T *Neutral P38117 1EFV B R164Q Disease P38117 1EFV B T154M Neutral P38398 1JM7 A C61G Disease P38398 1JM7 A C64G Disease P38398 1JM7 A C64Y Neutral P38398 1JM7 A E10K Disease P38398 1JM7 A E23K Disease P38398 1JM7 A L22S Disease P38398 1JM7 A R71K Disease P38398 1JM7 A Y64C *Neutral P38398 1T15 A A1708E Disease P38398 1T15 A C1662F *Neutral P38398 1T15 A C1697R Disease P38398 1T15 A D1692N Disease P38398 1T15 A F1662C Neutral P38398 1T15 A G1713V *Neutral P38398 1T15 A I1652M *Neutral P38398 1T15 A L1786P Disease P38398 1T15 A M1652I Neutral P38398 1T15 A M1665V *Neutral P38398 1T15 A M1775R Disease P38398 1T15 A P1749R Disease P38398 1T15 A P1776S Disease P38398 1T15 A P1812S Disease P38398 1T15 A R1699W Disease P38398 1T15 A V1665M Neutral P38398 1T15 A V1713G Neutral P38570 1N3Y A F182L Neutral P38570 1N3Y A L182F *Neutral P38646 2E8A A I95V Neutral P38646 2E8A A V95I *Neutral P39905 2V5E B D73N Disease P39905 2V5E B T77S Disease P39905 2V5E B I134M Disease P40189 1I1R A G126R Neutral P40189 1I1R A R126G *Neutral P40225 1V7M V E95G *Neutral P40225 1V7M V G95E Neutral P40337 1LM8 V E70K Disease P40337 1LM8 V F76I Disease P40337 1LM8 V F76L Disease P40337 1LM8 V F76S Disease P40337 1LM8 V G93C Disease P40337 1LM8 V G93D Disease P40337 1LM8 V G93S Disease P40337 1LM8 V L63P Disease P40337 1LM8 V L89H Disease P40337 1LM8 V L89P Disease P40337 1LM8 V N78H Disease P40337 1LM8 V N78S Disease P40337 1LM8 V N78T Disease P40337 1LM8 V P81S Disease P40337 1LM8 V P86A Disease P40337 1LM8 V P86H Disease P40337 1LM8 V P86L Disease P40337 1LM8 V P86R Disease P40337 1LM8 V P86S Disease P40337 1LM8 V Q96P Disease P40337 1LM8 V R64P Disease P40337 1LM8 V R79P Disease P40337 1LM8 V R82P Disease P40337 1LM8 V S65A Disease P40337 1LM8 V S65L Disease P40337 1LM8 V S65W Disease P40337 1LM8 V S68W Disease P40337 1LM8 V S80I Disease P40337 1LM8 V S80N Disease P40337 1LM8 V S80R Disease P40337 1LM8 V V74G Disease P40337 1LM8 V V84L Disease P40337 1LM8 V W88R Disease P40337 1LM8 V W88S Disease P40337 1LM8 V Y98H Disease P40337 1LM8 V A122I Disease P40337 1LM8 V A149T Disease P40337 1LM8 V C162F Disease P40337 1LM8 V C162R Disease P40337 1LM8 V C162W Disease P40337 1LM8 V C162Y Disease P40337 1LM8 V D121G Disease P40337 1LM8 V D126Y Disease P40337 1LM8 V D143E Disease P40337 1LM8 V E186K Disease P40337 1LM8 V F119L Disease P40337 1LM8 V F119S Disease P40337 1LM8 V F136C Disease P40337 1LM8 V F136S Disease P40337 1LM8 V F136Y Disease P40337 1LM8 V G106D Disease P40337 1LM8 V G114C Disease P40337 1LM8 V G114R Disease P40337 1LM8 V G114S Disease P40337 1LM8 V H110Y Neutral P40337 1LM8 V H115Q Disease P40337 1LM8 V H115R Disease P40337 1LM8 V H115Y Disease P40337 1LM8 V H191D Disease P40337 1LM8 V I147T Disease P40337 1LM8 V I180V Disease P40337 1LM8 V K159E Disease P40337 1LM8 V L101G Disease P40337 1LM8 V L101R Disease P40337 1LM8 V L116V Disease P40337 1LM8 V L118P Disease P40337 1LM8 V L118R Disease P40337 1LM8 V L128F Disease P40337 1LM8 V L158P Disease P40337 1LM8 V L158V Disease P40337 1LM8 V L163P Disease P40337 1LM8 V L178P Disease P40337 1LM8 V L178Q Disease P40337 1LM8 V L184P Disease P40337 1LM8 V L184R Disease P40337 1LM8 V L188P Disease P40337 1LM8 V L188Q Disease P40337 1LM8 V L188V Disease P40337 1LM8 V L198Q Disease P40337 1LM8 V L198R Disease P40337 1LM8 V N131K Disease P40337 1LM8 V N131T Disease P40337 1LM8 V P154L Disease P40337 1LM8 V P192S Disease P40337 1LM8 V Q145H Disease P40337 1LM8 V Q164H Disease P40337 1LM8 V Q164R Disease P40337 1LM8 V R107G Disease P40337 1LM8 V R107P Disease P40337 1LM8 V R161G Disease P40337 1LM8 V R161P Disease P40337 1LM8 V R161Q Disease P40337 1LM8 V R167G Disease P40337 1LM8 V R167Q Disease P40337 1LM8 V R167W Disease P40337 1LM8 V R176W Disease P40337 1LM8 V R200W Disease P40337 1LM8 V S111C Disease P40337 1LM8 V S111N Disease P40337 1LM8 V S111R Disease P40337 1LM8 V T105P Disease P40337 1LM8 V T157I Disease P40337 1LM8 V V130L Disease P40337 1LM8 V V155G Disease P40337 1LM8 V V155M Disease P40337 1LM8 V V166D Disease P40337 1LM8 V V166F Disease P40337 1LM8 V V170D Disease P40337 1LM8 V V170F Disease P40337 1LM8 V V170G Disease P40337 1LM8 V W117C Disease P40337 1LM8 V Y110H *Neutral P40337 1LM8 V Y112H Disease P40337 1LM8 V Y112N Disease P40337 1LM8 V Y156C Disease P40337 1LM8 V Y156D Disease P40337 1LM8 V Y156N Disease P40337 1LM8 V Y175D Disease P40394 1D1S A A79G *Neutral P40394 1D1S A G79A Neutral P40394 1U3U A H47R *Neutral P40394 1U3U A R47H Neutral P40394 1U3U A S59T *Neutral P40394 1U3U A T59S Neutral P40394 1U3U A C369R *Neutral P40394 1U3U A R369C Neutral P40937 1LFS A A13T Neutral P40937 1LFS A T13A *Neutral P41231 1Z8E A L46P Neutral P41231 1Z8E A P46L *Neutral P41240 1CSK A L45P *Neutral P41240 1CSK A P45L Neutral P42330 1S1P A C170R *Neutral P42330 1S1P A I175M *Neutral P42330 1S1P A M175I Neutral P42330 1S1P A P180S Neutral P42330 1S1P A R170C Neutral P42330 1S1P A S180P *Neutral P42575 1PYO C A13P *Neutral P42575 1PYO C P13A Neutral P42768 1CEE B L41P Disease P42771 1A5E A A20P Disease P42771 1A5E A A20S Disease P42771 1A5E A A57V Disease P42771 1A5E A A60T Neutral P42771 1A5E A A60V Disease P42771 1A5E A A68L Disease P42771 1A5E A A68T Disease P42771 1A5E A A68V Neutral P42771 1A5E A A85T Neutral P42771 1A5E A C72G Disease P42771 1A5E A D14E Disease P42771 1A5E A D74N Disease P42771 1A5E A D74V Disease P42771 1A5E A D74Y Disease P42771 1A5E A D84E Disease P42771 1A5E A D84H Disease P42771 1A5E A D84N Disease P42771 1A5E A D84Y Disease P42771 1A5E A E26D Disease P42771 1A5E A E33D Disease P42771 1A5E A E69K Disease P42771 1A5E A E69V Disease P42771 1A5E A E88D Disease P42771 1A5E A G23D Disease P42771 1A5E A G35A Disease P42771 1A5E A G35E Disease P42771 1A5E A G35V Disease P42771 1A5E A G67R Disease P42771 1A5E A G89D Disease P42771 1A5E A G89S Disease P42771 1A5E A H66Y Disease P42771 1A5E A H83N Disease P42771 1A5E A H83Q Neutral P42771 1A5E A H83Y Disease P42771 1A5E A H98P Disease P42771 1A5E A H98Q Disease P42771 1A5E A I49S Disease P42771 1A5E A I49T Neutral P42771 1A5E A I56S *Neutral P42771 1A5E A L16P Disease P42771 1A5E A L32P Disease P42771 1A5E A L62P Disease P42771 1A5E A L94Q Disease P42771 1A5E A L97R Disease P42771 1A5E A M53I Disease P42771 1A5E A N71K Disease P42771 1A5E A N71S Neutral P42771 1A5E A P48L Disease P42771 1A5E A P81L Disease P42771 1A5E A P81T Disease P42771 1A5E A Q50R Disease P42771 1A5E A Q58R *Neutral P42771 1A5E A Q83H *Neutral P42771 1A5E A R24C Disease P42771 1A5E A R24P Disease P42771 1A5E A R58Q Neutral P42771 1A5E A R80L Disease P42771 1A5E A R80P Disease P42771 1A5E A R87P Disease P42771 1A5E A R87W Disease P42771 1A5E A R99P Disease P42771 1A5E A R99Q Disease P42771 1A5E A R99W Neutral P42771 1A5E A S56I Neutral P42771 1A5E A S71N *Neutral P42771 1A5E A T49I *Neutral P42771 1A5E A T60A *Neutral P42771 1A5E A T77P Disease P42771 1A5E A T85A *Neutral P42771 1A5E A T93A Disease P42771 1A5E A V59G Disease P42771 1A5E A V68A *Neutral P42771 1A5E A V95A Disease P42771 1A5E A W99R *Neutral P42771 1A5E A A100L Disease P42771 1A5E A A100P Neutral P42771 1A5E A A102E Disease P42771 1A5E A A102T Neutral P42771 1A5E A A118T Disease P42771 1A5E A A127S Disease P42771 1A5E A A132P Disease P42771 1A5E A A134V Disease P42771 1A5E A A148T Neutral P42771 1A5E A C124R *Neutral P42771 1A5E A D108H Disease P42771 1A5E A D108Y Disease P42771 1A5E A E119Q Disease P42771 1A5E A E120A Disease P42771 1A5E A E120K Disease P42771 1A5E A G101W Disease P42771 1A5E A G122R Disease P42771 1A5E A G122S Disease P42771 1A5E A G150V Disease P42771 1A5E A H107R *Neutral P42771 1A5E A H123Q Disease P42771 1A5E A H142Y Disease P42771 1A5E A L117M Disease P42771 1A5E A P100A *Neutral P42771 1A5E A P114L Disease P42771 1A5E A R107C Disease P42771 1A5E A R107H Neutral P42771 1A5E A R124C Neutral P42771 1A5E A R124H Disease P42771 1A5E A R144C Disease P42771 1A5E A T102A *Neutral P42771 1A5E A T148A *Neutral P42771 1A5E A V126D Disease P42773 1IHB A A72P Disease P42773 1IHB A M126T *Neutral P42773 1IHB A T126M Neutral P43026 3EVS B C19Y Disease P43026 3EVS B H59L Disease P43026 3EVS B L60P Disease P43026 3EVS B P55T Disease P43026 3EVS B R57L Disease P43026 3EVS B S58T Disease P43026 3EVS B S94N Disease P43026 3EVS B E110K Disease P43235 1BY8 A G64E Disease P43235 1TU6 A A277V Disease P43235 1TU6 A G146R Disease P43235 1TU6 A L309P Disease P43320 1YTQ A A64S Neutral P43320 1YTQ A S64A *Neutral P43351 1H2I A R70W Neutral P43351 1H2I A W70R *Neutral P43405 1A81 A H45R *Neutral P43405 1A81 A R45H Neutral P43487 1K5D B A145V Neutral P43487 1K5D B V145A *Neutral P43626 1NKR A P16R Neutral P43626 1NKR A R16P *Neutral P43626 1NKR A D163N Neutral P43626 1NKR A L114P *Neutral P43626 1NKR A N163D *Neutral P43626 1NKR A P114L Neutral P43626 1NKR A P154T Neutral P43626 1NKR A T154P *Neutral P43628 1B6U A H13Q Neutral P43628 1B6U A P16R Neutral P43628 1B6U A Q13H *Neutral P43628 1B6U A R16P *Neutral P43630 1B6U A E35Q *Neutral P43630 1B6U A F45Y Neutral P43630 1B6U A H50R Neutral P43630 1B6U A L11R Neutral P43630 1B6U A Q35E Neutral P43630 1B6U A R11L *Neutral P43630 1B6U A R50H *Neutral P43630 1B6U A Y45F *Neutral P43630 1M4K A F45Y *Neutral P43630 1M4K A Y45F Neutral P43630 1NKR A F45Y Neutral P43630 1NKR A L90V *Neutral P43630 1NKR A V90L Neutral P43630 1NKR A Y45F *Neutral P43630 1NKR A H182R Neutral P43630 1NKR A R182H *Neutral P43630 2DLI A F45Y Neutral P43630 2DLI A P16R *Neutral P43630 2DLI A R16P Neutral P43630 2DLI A Y45F *Neutral P45381 2O4H A A57T Disease P45381 2O4H A D68A Disease P45381 2O4H A E24G Disease P45381 2O4H A G27R Disease P45381 2O4H A H21P Disease P45381 2O4H A I16T Disease P45381 2O4H A A287T Disease P45381 2O4H A A305E Disease P45381 2O4H A C152R Disease P45381 2O4H A C152W Disease P45381 2O4H A C152Y Disease P45381 2O4H A D114E Disease P45381 2O4H A D114Y Disease P45381 2O4H A D249V Disease P45381 2O4H A E285A Disease P45381 2O4H A F295S Disease P45381 2O4H A G123E Disease P45381 2O4H A G274R Disease P45381 2O4H A H244R Disease P45381 2O4H A I143T Disease P45381 2O4H A M195R Disease P45381 2O4H A P181T Disease P45381 2O4H A P183H Disease P45381 2O4H A P280L Disease P45381 2O4H A P280S Disease P45381 2O4H A R168C Disease P45381 2O4H A R168H Disease P45381 2O4H A V186F Disease P45381 2O4H A Y231C Disease P45452 1UC1 A H2L Neutral P45452 1UC1 A L2H *Neutral P45452 1UC1 A F75S Disease P45877 2ESL A K86R Neutral P45877 2ESL A R86K *Neutral P45877 2ESL A N190S Neutral P45877 2ESL A S190N *Neutral P45954 2JIF A E376G Neutral P45954 2JIF A G209S *Neutral P45954 2JIF A G376E *Neutral P45954 2JIF A L255F Disease P45954 2JIF A S209G Neutral P47712 1BCI A G103R Neutral P47712 1BCI A R103G *Neutral P48436 1SX9 A P8L Disease P48436 1SX9 A A19V Disease P48436 1SX9 A A58T Disease P48436 1SX9 A F12L Disease P48436 1SX9 A F12S Disease P48436 1SX9 A F54L Disease P48436 1SX9 A H65Y Disease P48436 1SX9 A P70R Disease P48436 1SX9 A R52P Disease P48436 1SX9 A W43R Disease P48449 1W6J A H310R Neutral P48449 1W6J A L642V Neutral P48449 1W6J A L688P *Neutral P48449 1W6J A P688L Neutral P48449 1W6J A Q175R *Neutral P48449 1W6J A R175Q Neutral P48449 1W6J A R310H *Neutral P48449 1W6J A R614W Neutral P48449 1W6J A V642L *Neutral P48449 1W6J A W614R *Neutral P48637 2HGS A A26D Disease P48637 2HGS A D219A Disease P48637 2HGS A D219G Disease P48637 2HGS A D469E Disease P48637 2HGS A E437K *Neutral P48637 2HGS A G464V Disease P48637 2HGS A K437E Neutral P48637 2HGS A L188P Disease P48637 2HGS A L254R Disease P48637 2HGS A L286Q Disease P48637 2HGS A Q236R *Neutral P48637 2HGS A R236Q Neutral P48637 2HGS A R267W Disease P48637 2HGS A R283C Disease P48637 2HGS A R330C Disease P48637 2HGS A Y270C Disease P48637 2HGS A Y270H Disease P48728 1WSR A G19R Disease P48728 1WSR A H14R Disease P48728 1WSR A D248H Disease P48728 1WSR A E183K Disease P48728 1WSR A G241D Disease P48728 1WSR A N117I Disease P48728 1WSR A R292H Disease P49366 1ROZ A D174E *Neutral P49366 1ROZ A E174D Neutral P49419 1O02 A E320V Neutral P49419 1O02 A E479K Neutral P49419 1O02 A K479E *Neutral P49419 1O02 A V320E *Neutral P49419 2W8N A I406V *Neutral P49419 2W8N A V406I Neutral P49638 1OIZ A R59W Disease P49638 1OIZ A A120T Disease P49638 1OIZ A E141K Disease P49638 1OIZ A G246R Disease P49638 1OIZ A H101Q Disease P49638 1OIZ A R192H Disease P49638 1OIZ A R221W Disease P49638 1OIZ A S172T *Neutral P49638 1OIZ A T172S Neutral P49840 2DFM A E12Q *Neutral P49840 2DFM A Q12E Neutral P49888 1G3M A D22Y Neutral P49888 1G3M A Y22D *Neutral P49917 3II6 Y A857T Neutral P49917 3II6 Y I658V Neutral P49917 3II6 Y T857A *Neutral P49917 3II6 Y V658I *Neutral P50053 2HQQ A A43T Disease P50053 2HQQ A G40R Disease P50053 2HQQ A I49V *Neutral P50053 2HQQ A V49I Neutral P50053 2HQQ A G159R *Neutral P50053 2HQQ A R159G Neutral P50135 1JQD B I105T *Neutral P50135 1JQD B T105I Neutral P50281 1BQQ M I233V Neutral P50281 1BQQ M V233I *Neutral P50281 3C7X A H431R *Neutral P50281 3C7X A R431H Neutral P50391 2IK5 _ A99S Neutral P50391 2IK5 _ S99A *Neutral P50391 2IK5 _ C240R *Neutral P50391 2IK5 _ R240C Neutral P50402 1JEI A S53F Disease P50440 1JDW A H110Q *Neutral P50440 1JDW A Q110H Neutral P50461 2O10 A C58G Disease P50461 2O10 A L44P Disease P50552 1EGX A A104T Neutral P50552 1EGX A T104A *Neutral P50613 1LG3 A A163G *Neutral P50613 1LG3 A G163A Neutral P50613 1LG3 A M285T *Neutral P50613 1LG3 A T285M Neutral P50895 2PET A H46R *Neutral P50895 2PET A R46H Neutral P50895 2PET A I165V *Neutral P50895 2PET A K173M *Neutral P50895 2PET A M173K Neutral P50895 2PET A V165I Neutral P51124 2ZGC A G196R Neutral P51124 2ZGC A R196G *Neutral P51161 1O1U A H32R *Neutral P51161 1O1U A M78T *Neutral P51161 1O1U A R32H Neutral P51161 1O1U A S54Y Neutral P51161 1O1U A T78M Neutral P51161 1O1U A Y54S *Neutral P51511 1BQQ M D273N Neutral P51511 1BQQ M N273D *Neutral P51511 1HFC A I191V Neutral P51511 1HFC A R262S Neutral P51511 1HFC A S262R *Neutral P51511 1HFC A V191I *Neutral P51511 1I76 A D173V Neutral P51511 1I76 A N226Y Neutral P51511 1I76 A V173D *Neutral P51511 1I76 A Y226N *Neutral P51511 1PEX A D385G Neutral P51511 1PEX A G385D *Neutral P51511 3C7X A I355M *Neutral P51511 3C7X A M355I Neutral P51570 1YH7 A G36R Disease P51570 1YH7 A H44Y Disease P51570 1YH7 A P28T Disease P51570 1YH7 A R68C Disease P51570 1YH7 A V32M Disease P51570 1YH7 A A198V Disease P51570 1YH7 A A338V *Neutral P51570 1YH7 A A384P Disease P51570 1YH7 A D274G *Neutral P51570 1YH7 A G274D Neutral P51570 1YH7 A G346S Disease P51570 1YH7 A G349S Disease P51570 1YH7 A I184M Neutral P51570 1YH7 A M184I *Neutral P51570 1YH7 A R239Q Disease P51570 1YH7 A T288M Disease P51570 1YH7 A V338A Neutral P51580 2H11 A A80P Disease P51580 2H11 A L49S Neutral P51580 2H11 A S49L *Neutral P51580 2H11 A A154T Disease P51580 2H11 A F180Y *Neutral P51580 2H11 A H179Q *Neutral P51580 2H11 A H227Q Disease P51580 2H11 A Q179H Neutral P51580 2H11 A R215H Disease P51580 2H11 A Y180F Neutral P51580 2H11 A Y240C Disease P51582 2B6Q A A234S *Neutral P51582 2B6Q A S234A Neutral P51649 2W8N A C93F Disease P51649 2W8N A C223Y Disease P51649 2W8N A G176R Disease P51649 2W8N A G268E Disease P51649 2W8N A G409D Disease P51649 2W8N A G533R Disease P51649 2W8N A H180Y Neutral P51649 2W8N A L182P *Neutral P51649 2W8N A N255S Disease P51649 2W8N A N335K Disease P51649 2W8N A P182L Neutral P51649 2W8N A P382L Disease P51649 2W8N A P382Q Disease P51649 2W8N A T233M Disease P51649 2W8N A V487E Disease P51649 2W8N A Y180H *Neutral P51659 1IKT A I71T *Neutral P51659 1IKT A T71I Neutral P51659 1IKT A M112V Neutral P51659 1IKT A V112M *Neutral P51659 1ZBQ A F90L Neutral P51659 1ZBQ A G16S Disease P51659 1ZBQ A L90F *Neutral P51659 1ZBQ A H106R *Neutral P51659 1ZBQ A K140N Neutral P51659 1ZBQ A N140K *Neutral P51659 1ZBQ A R106H Neutral P51659 1ZBQ A S292T *Neutral P51659 1ZBQ A T292S Neutral P51671 1EOT A K63T Neutral P51671 1EOT A T63K *Neutral P51681 1ND8 A A29S Neutral P51681 1ND8 A A73V Neutral P51681 1ND8 A C20S Neutral P51681 1ND8 A L55Q Neutral P51681 1ND8 A Q55L *Neutral P51681 1ND8 A R60S Neutral P51681 1ND8 A S20C *Neutral P51681 1ND8 A S29A *Neutral P51681 1ND8 A S60R *Neutral P51681 1ND8 A V73A *Neutral P51681 1ND8 A G301V Neutral P51681 1ND8 A V301G *Neutral P51857 1ADS A E89K *Neutral P51857 1ADS A H41L Neutral P51857 1ADS A K89E Neutral P51857 1ADS A L41H *Neutral P51857 1RY0 A H5Q *Neutral P51857 1RY0 A Q5H Neutral P51857 1S1P A Q66R *Neutral P51857 1S1P A R66Q Neutral P51857 3BUV A L106F Disease P51857 3BUV A P133R Disease P51857 3BUV A P198L Disease P51857 3BUV A R261C Disease P51857 3C3U A L172Q *Neutral P51857 3C3U A Q172L Neutral P51946 1KXU A L28R *Neutral P51946 1KXU A M54V Neutral P51946 1KXU A R28L Neutral P51946 1KXU A V54M *Neutral P51946 1KXU A A270V *Neutral P51946 1KXU A K138R Neutral P51946 1KXU A R138K *Neutral P51946 1KXU A V270A Neutral P52597 2HGL A K87R Neutral P52597 2HGL A R87K *Neutral P52790 1HKB A L776M Neutral P52790 1HKB A M776L *Neutral P52895 1XJB B F46Y Neutral P52895 1XJB B Y46F *Neutral P52895 1XJB B L172Q Neutral P52895 1XJB B Q172L *Neutral P53350 2V5Q A D297N *Neutral P53350 2V5Q A F261L *Neutral P53350 2V5Q A L261F Neutral P53350 2V5Q A N297D Neutral P53350 3FVH A H463L *Neutral P53350 3FVH A H518R *Neutral P53350 3FVH A H599R *Neutral P53350 3FVH A L463H Neutral P53350 3FVH A L595S *Neutral P53350 3FVH A R518H Neutral P53350 3FVH A R599H Neutral P53350 3FVH A S595L Neutral P53634 2DJF B C267Y Disease P53634 2DJF B D212Y Disease P53634 2DJF B E295G Disease P53634 2DJF B G276D Disease P53634 2DJF B G276S Disease P53634 2DJF B G277S Disease P53634 2DJF B G277V Disease P53634 2DJF B Q228L Disease P53634 2DJF B Q262R Disease P53634 2DJF B Q288R Disease P53634 2DJF B R248H Disease P53634 2DJF B R248P Disease P53634 2DJF B R315C Disease P53634 2DJF B V225F Disease P53634 2DJF B Y270H Disease P53634 2DJF B Y280N Disease P53634 2DJF B Y316C Disease P53634 2DJF B Y323C Disease P53708 2VDR A I9T *Neutral P53708 2VDR A T9I Neutral P53708 2VDR A A282G *Neutral P53708 2VDR A G282A Neutral P54725 1IFY A M200T *Neutral P54725 1IFY A Q179R *Neutral P54725 1IFY A R179Q Neutral P54725 1IFY A T200M Neutral P54819 2C9Y A A209T Neutral P54819 2C9Y A D165G Disease P54819 2C9Y A R103W Disease P54819 2C9Y A T209A *Neutral P55769 2OZB A N19T *Neutral P55769 2OZB A T19N Neutral P55854 2IO1 D P38S Neutral P55854 2IO1 D S38P *Neutral P56279 1JSG A I56V *Neutral P56279 1JSG A V56I Neutral P56545 2OME A D47E *Neutral P56545 2OME A E47D Neutral P58335 1SHU X L45P Disease P58335 1SHU X C218R Disease P58335 1SHU X G105D Disease P58335 1SHU X I189T Disease P59534 2GFZ A E197K *Neutral P59534 2GFZ A F193S *Neutral P59534 2GFZ A K197E Neutral P59534 2GFZ A S193F Neutral P60174 2JK2 B C41Y Disease P60174 2JK2 B G72A Disease P60174 2JK2 B E104D Disease P60174 2JK2 B F240L Disease P60174 2JK2 B I170V Disease P60174 2JK2 B V154M Disease P60174 2JK2 B V231M Disease P60709 3BYH A L243P *Neutral P60709 3BYH A P243L Neutral P60709 3BYH A R183W Disease P61278 1P2W A A11V Neutral P61278 1P2W A N61T Neutral P61278 1P2W A T61N *Neutral P61278 1P2W A V11A *Neutral P61626 1JSF A D67H Disease P61626 1JSF A I56T Disease P61626 1JSF A N70T *Neutral P61626 1JSF A T70N Neutral P61956 1WM2 A D16N Neutral P61956 1WM2 A N16D *Neutral P62070 2ERY B Q72L Disease P62158 2F3Y A M72T Neutral P62158 2F3Y A T72M *Neutral P62826 3GJ3 A I95R *Neutral P62826 3GJ3 A R95I Neutral P63000 2VRW A A59T Neutral P63000 2VRW A D26N *Neutral P63000 2VRW A D63G Neutral P63000 2VRW A F28L Neutral P63000 2VRW A G63D *Neutral P63000 2VRW A G93V *Neutral P63000 2VRW A I93V *Neutral P63000 2VRW A L28F *Neutral P63000 2VRW A N26D Neutral P63000 2VRW A T59A *Neutral P63000 2VRW A V93G Neutral P63000 2VRW A V93I Neutral P63000 2VRW A E133K *Neutral P63000 2VRW A I108T *Neutral P63000 2VRW A I135T *Neutral P63000 2VRW A K130R Neutral P63000 2VRW A K133E Neutral P63000 2VRW A R130K *Neutral P63000 2VRW A T108I Neutral P63000 2VRW A T135I Neutral P67774 2IE4 C A52V *Neutral P67774 2IE4 C V52A Neutral P68871 1IRD B D211V *Neutral P68871 1IRD B H202L Neutral P68871 1IRD B L202H *Neutral P68871 1IRD B V211D Neutral P69891 1I3D A I75T Neutral P69891 1I3D A T75I *Neutral P69892 1FDH G I75T Neutral P69892 1FDH G T75I *Neutral P69905 1IRD A K60N Neutral P69905 1IRD A K68N *Neutral P69905 1IRD A L44P *Neutral P69905 1IRD A L91P Neutral P69905 1IRD A N60K *Neutral P69905 1IRD A N68K Neutral P69905 1IRD A P44L Neutral P69905 1IRD A P91L *Neutral P69905 1IRD A R102S *Neutral P69905 1IRD A S102R Neutral P78324 2JJT B A27V *Neutral P78324 2JJT B A45G Neutral P78324 2JJT B C77S *Neutral P78324 2JJT B D10E Neutral P78324 2JJT B D65E *Neutral P78324 2JJT B E10D *Neutral P78324 2JJT B E47K Neutral P78324 2JJT B E65D Neutral P78324 2JJT B G45A *Neutral P78324 2JJT B G79S *Neutral P78324 2JJT B H24R Neutral P78324 2JJT B H51N *Neutral P78324 2JJT B I22T Neutral P78324 2JJT B I31N Neutral P78324 2JJT B K47E *Neutral P78324 2JJT B L14S *Neutral P78324 2JJT B L66S *Neutral P78324 2JJT B N31I *Neutral P78324 2JJT B N51H Neutral P78324 2JJT B Q95R *Neutral P78324 2JJT B R24H *Neutral P78324 2JJT B R38W *Neutral P78324 2JJT B R77S *Neutral P78324 2JJT B R95Q Neutral P78324 2JJT B S14L Neutral P78324 2JJT B S20T Neutral P78324 2JJT B S66L Neutral P78324 2JJT B S77C Neutral P78324 2JJT B S77R Neutral P78324 2JJT B S79G Neutral P78324 2JJT B T20S *Neutral P78324 2JJT B T22I *Neutral P78324 2JJT B V27A Neutral P78324 2JJT B W38R Neutral P78324 2JJT B F103L Neutral P78324 2JJT B L103F *Neutral P78380 1YPQ B K167N Neutral P78380 1YPQ B N167K *Neutral P78417 1EEM A A140D Neutral P78417 1EEM A A236V Neutral P78417 1EEM A D140A *Neutral P78417 1EEM A E208K Neutral P78417 1EEM A K208E *Neutral P78417 1EEM A V236A *Neutral P78504 2VJ2 B C187S Disease P78504 2VJ2 B C187Y Disease P78504 2VJ2 B C220F Disease P78504 2VJ2 B C229G Disease P78504 2VJ2 B C229Y Disease P78504 2VJ2 B C271R Disease P78504 2VJ2 B C284F Disease P78504 2VJ2 B G256S Disease P78504 2VJ2 B G274D Disease P78504 2VJ2 B P269L Disease P78504 2VJ2 B R252G Disease P78504 2VJ2 B W224C Disease P78504 2VJ2 B W288C Disease P78540 1PQ3 A G240R Neutral P78540 1PQ3 A R240G *Neutral P78556 1M8A A M21V *Neutral P78556 1M8A A V21M Neutral P79483 2Q6W B A73G *Neutral P79483 2Q6W B G73A Neutral P98161 1B4R A R57L Disease P99999 1J3S A G41S Disease P99999 1J3S A K55R Neutral P99999 1J3S A R55K *Neutral Q00403 1DL6 A P19S Neutral Q00403 1DL6 A S19P *Neutral Q00526 1LFN A H214R *Neutral Q00526 1LFN A I124T Neutral Q00526 1LFN A I226T *Neutral Q00526 1LFN A M264T Neutral Q00526 1LFN A R214H Neutral Q00526 1LFN A T124I *Neutral Q00526 1LFN A T226I Neutral Q00526 1LFN A T264M *Neutral Q00534 1BLX A D110N Neutral Q00534 1BLX A N110D *Neutral Q00535 1LFR A D225E *Neutral Q00535 1LFR A E225D Neutral Q01196 1E50 C R174Q Disease Q01196 1LJM B R2139Q Disease Q02318 1MFX A G112E Disease Q02318 1MFX A M142T *Neutral Q02318 1MFX A R362C Disease Q02318 1MFX A R362S Disease Q02318 1MFX A R372Q Disease Q02318 1MFX A R441Q Disease Q02318 1MFX A R441W Disease Q02318 1MFX A R446C Disease Q02318 1MFX A T142M Neutral Q02846 1AWL A L954P Disease Q03013 4GTU A P1S *Neutral Q03013 4GTU A S1P Neutral Q03013 4GTU A F208Y *Neutral Q03013 4GTU A L207V Neutral Q03013 4GTU A M211V *Neutral Q03013 4GTU A V207L *Neutral Q03013 4GTU A V211M Neutral Q03013 4GTU A Y208F Neutral Q03154 1Q7L A N179S Neutral Q03154 1Q7L A R197W Disease Q03154 1Q7L A S179N *Neutral Q03393 3I2B A D96N Disease Q03393 3I2B A E35G Disease Q03393 3I2B A L26F Disease Q03393 3I2B A N36K Disease Q03393 3I2B A N47D Disease Q03393 3I2B A N52S Disease Q03393 3I2B A P87L Disease Q03393 3I2B A P87S Disease Q03393 3I2B A R16C Disease Q03393 3I2B A R25G Disease Q03393 3I2B A R25Q Disease Q03393 3I2B A T67M Disease Q03393 3I2B A V56M Disease Q03393 3I2B A V70D Disease Q03393 3I2B A V97M Disease Q03393 3I2B A Y99C Disease Q03393 3I2B A D116G Disease Q03393 3I2B A D136G Disease Q03393 3I2B A D136V Disease Q03393 3I2B A F100V Disease Q03393 3I2B A I114V Disease Q03393 3I2B A K129E Disease Q03393 3I2B A T106M Disease Q03393 3I2B A V124L Disease Q03518 1JJ7 A D637G Neutral Q03518 1JJ7 A G637D *Neutral Q03518 1JJ7 A I518V *Neutral Q03518 1JJ7 A Q648R *Neutral Q03518 1JJ7 A Q708R Neutral Q03518 1JJ7 A R648Q Neutral Q03518 1JJ7 A R659Q Disease Q03518 1JJ7 A R708Q *Neutral Q03518 1JJ7 A V518I Neutral Q03692 1GR3 A C591R Disease Q03692 1GR3 A D648G Disease Q03692 1GR3 A G595E Disease Q03692 1GR3 A G595R Disease Q03692 1GR3 A G618V Disease Q03692 1GR3 A L614P Disease Q03692 1GR3 A L644R Disease Q03692 1GR3 A M603V *Neutral Q03692 1GR3 A N617K Disease Q03692 1GR3 A Q653P Disease Q03692 1GR3 A S600P Disease Q03692 1GR3 A S671P Disease Q03692 1GR3 A V603M Neutral Q03692 1GR3 A W651R Disease Q03692 1GR3 A Y582D Disease Q03692 1GR3 A Y597C Disease Q03692 1GR3 A Y597H Disease Q03692 1GR3 A Y598D Disease Q04609 1Z8L A H75Y *Neutral Q04609 1Z8L A Y75H Neutral Q04609 1Z8L A L627V *Neutral Q04609 1Z8L A V627L Neutral Q04756 2R0L A Q241R *Neutral Q04756 2R0L A R241Q Neutral Q04756 2R0L A H111CR *Neutral Q04756 2R0L A R111CH Neutral Q04760 1QIP B C18Y Neutral Q04760 1QIP B Y18C *Neutral Q04760 1QIP B A110E *Neutral Q04760 1QIP B E110A Neutral Q04828 3C3U A H170R *Neutral Q04828 3C3U A R170H Neutral Q04844 2DF9 A L2F Disease Q04844 2DF9 A L50F Disease Q04844 2DF9 A P26L Disease Q04844 2DF9 A R92W Disease Q04844 2DF9 A T45P Disease Q05066 1HRY A M9I Disease Q05066 1HRY A M9R Disease Q05066 1HRY A R7G Disease Q05066 1HRY A V5A Disease Q05066 1HRY A V5L Disease Q05066 1HRY A A58T Disease Q05066 1HRY A F12V Disease Q05066 1HRY A F54S Disease Q05066 1HRY A G40E Disease Q05066 1HRY A G40R Disease Q05066 1HRY A I13T Disease Q05066 1HRY A I35M Disease Q05066 1HRY A K51I Disease Q05066 1HRY A L46H Disease Q05066 1HRY A M23T Disease Q05066 1HRY A N32Y Disease Q05066 1HRY A P53R Disease Q05066 1HRY A P70L Disease Q05066 1HRY A R21S Disease Q05066 1HRY A S36G Disease Q05066 1HRY A Y72C Disease Q05066 1HRY A Y72F Disease Q05315 1G86 A A28V *Neutral Q05315 1G86 A V28A Neutral Q05397 1K04 A D1030E Neutral Q05397 1K04 A E1030D *Neutral Q06187 1K2P A A508D Disease Q06187 1K2P A A523E Disease Q06187 1K2P A A582V Disease Q06187 1K2P A A607D Disease Q06187 1K2P A A622P Disease Q06187 1K2P A C502F Disease Q06187 1K2P A C502W Disease Q06187 1K2P A C506R Disease Q06187 1K2P A C506Y Disease Q06187 1K2P A C633Y Disease Q06187 1K2P A D521G Disease Q06187 1K2P A D521H Disease Q06187 1K2P A D521N Disease Q06187 1K2P A E445D Disease Q06187 1K2P A E567K Disease Q06187 1K2P A E589D Disease Q06187 1K2P A E589G Disease Q06187 1K2P A E589K Disease Q06187 1K2P A F559S Disease Q06187 1K2P A F583S Disease Q06187 1K2P A F644L Disease Q06187 1K2P A F644S Disease Q06187 1K2P A G414R Disease Q06187 1K2P A G462D Disease Q06187 1K2P A G462V Disease Q06187 1K2P A G594E Disease Q06187 1K2P A G594R Disease Q06187 1K2P A G613D Disease Q06187 1K2P A I429N Disease Q06187 1K2P A I630M *Neutral Q06187 1K2P A K430E Disease Q06187 1K2P A K430R Disease Q06187 1K2P A L408P Disease Q06187 1K2P A L512P Disease Q06187 1K2P A L512Q Disease Q06187 1K2P A L518R Disease Q06187 1K2P A L542P Disease Q06187 1K2P A L647P Disease Q06187 1K2P A L652P Disease Q06187 1K2P A M477R Disease Q06187 1K2P A M509I Disease Q06187 1K2P A M509V Disease Q06187 1K2P A M587L Disease Q06187 1K2P A M630I Neutral Q06187 1K2P A M630K Disease Q06187 1K2P A M630T Disease Q06187 1K2P A N526K Disease Q06187 1K2P A P619A Disease Q06187 1K2P A P619S Disease Q06187 1K2P A P619T Disease Q06187 1K2P A R520Q Disease Q06187 1K2P A R525G Disease Q06187 1K2P A R525P Disease Q06187 1K2P A R525Q Disease Q06187 1K2P A R544G Disease Q06187 1K2P A R544K Disease Q06187 1K2P A R562P Disease Q06187 1K2P A R562W Disease Q06187 1K2P A R641C Disease Q06187 1K2P A R641H Disease Q06187 1K2P A S578Y Disease Q06187 1K2P A S592P Disease Q06187 1K2P A V535F Disease Q06187 1K2P A V626G Disease Q06187 1K2P A W563L Disease Q06187 1K2P A W581R Disease Q06187 1K2P A Y418H Disease Q06187 1K2P A Y476D Disease Q06187 1K2P A Y598C Disease Q06187 2GE9 A D39E Disease Q06187 2GE9 A G33E Disease Q06187 2GE9 A G33R Disease Q06187 2GE9 A H93Q Disease Q06187 2GE9 A H95P Disease Q06187 2GE9 A L26P Disease Q06187 2GE9 A L89F Disease Q06187 2GE9 A N96Y Disease Q06187 2GE9 A R19Q Disease Q06187 2GE9 A R19W Disease Q06187 2GE9 A R38G Disease Q06187 2GE9 A R38T Disease Q06187 2GE9 A S97F Disease Q06187 2GE9 A V50A Disease Q06187 2GE9 A Y65S Disease Q06187 2GE9 A Y92C Disease Q06187 2GE9 A I101M Disease Q06187 2GE9 A L100F Disease Q06187 2GE9 A R103G Disease Q06330 2F8X C D320H Neutral Q06330 2F8X C E277K *Neutral Q06330 2F8X C H320D *Neutral Q06330 2F8X C I394V Neutral Q06330 2F8X C K277E Neutral Q06330 2F8X C K282M *Neutral Q06330 2F8X C M282K Neutral Q06330 2F8X C P411S Neutral Q06330 2F8X C Q405R *Neutral Q06330 2F8X C R405Q Neutral Q06330 2F8X C S411P *Neutral Q06330 2F8X C V394I *Neutral Q07812 1F16 A G39R Neutral Q07812 1F16 A G67R Disease Q07812 1F16 A R39G *Neutral Q07812 1F16 A G108V Disease Q07869 2P54 A A227V *Neutral Q07869 2P54 A A268V Neutral Q07869 2P54 A D304N Neutral Q07869 2P54 A G395R Neutral Q07869 2P54 A N304D *Neutral Q07869 2P54 A R395G *Neutral Q07869 2P54 A R409T Neutral Q07869 2P54 A T409R *Neutral Q07869 2P54 A V227A Neutral Q07869 2P54 A V268A *Neutral Q07889 1AWE A C41Y Disease Q07889 1AWE A E33K Disease Q07889 1AWE A G34R Disease Q07889 1AWE A W32R Disease Q07889 1AWE A L150P Disease Q07889 1AWE A S148R Disease Q07960 1OW3 A C172R *Neutral Q07960 1OW3 A R172C Neutral Q08257 1YB5 A P66S Neutral Q08257 1YB5 A S66P *Neutral Q09470 2AFL A L4I Disease Q09470 2AFL A S17I Disease Q09470 2AFL A V79I Disease Q10471 2FFU A M554V *Neutral Q10471 2FFU A V554M Neutral Q12809 1UJL A G3C Disease Q12809 1UJL A G3R Disease Q12809 1UJL A D40N Disease Q12809 1UJL A G15S Disease Q12809 1UJL A G32S Disease Q12809 1UJL A G35S Disease Q12809 1UJL A I24R Disease Q12809 1UJL A I24T Disease Q12809 1UJL A N19D Disease Q12809 1UJL A N19K Disease Q12809 1UJL A R13C Disease Q12809 1UJL A W16C Disease Q12809 1UJL A Y42H Disease Q12888 2G3R A G1488W Neutral Q12888 2G3R A W1488G *Neutral Q12923 1D5G A L59P Neutral Q12923 1D5G A P59L *Neutral Q12923 1WCH A I2458V Neutral Q12923 1WCH A V2458I *Neutral Q13093 3D59 B H92R *Neutral Q13093 3D59 B R92H Neutral Q13093 3D59 B A379V *Neutral Q13093 3D59 B I198T Neutral Q13093 3D59 B K191N Neutral Q13093 3D59 B N191K *Neutral Q13093 3D59 B Q281R Disease Q13093 3D59 B T198I *Neutral Q13093 3D59 B V279F Disease Q13093 3D59 B V379A Neutral Q13231 1WB0 A H171Q *Neutral Q13231 1WB0 A Q171H Neutral Q13263 2RO1 A M794T *Neutral Q13263 2RO1 A T794M Neutral Q13291 2DZF _ F11L Neutral Q13291 2DZF _ L11F *Neutral Q13291 2DZF _ P333T Neutral Q13291 2DZF _ T333P *Neutral Q13303 1ZSX A E74K Neutral Q13303 1ZSX A K74E *Neutral Q13323 2IPE _ E19K Neutral Q13323 2IPE _ I26T *Neutral Q13323 2IPE _ K19E *Neutral Q13323 2IPE _ T26I Neutral Q13323 2IPE _ L148P Neutral Q13323 2IPE _ P148L *Neutral Q13395 2HA8 A I24V Neutral Q13395 2HA8 A V24I *Neutral Q13464 2ETR A N108S *Neutral Q13464 2ETR A S108N Neutral Q13469 1A02 N H446R Neutral Q13469 1A02 N R446H *Neutral Q13520 1H6I A D165G *Neutral Q13520 1H6I A G165D Neutral Q13564 1YOV A F101S *Neutral Q13564 1YOV A S101F Neutral Q13569 1WYW A G199S Neutral Q13569 1WYW A S199G *Neutral Q13619 2HYE C K614R Neutral Q13619 2HYE C R614K *Neutral Q13620 2HYE C K644R Neutral Q13620 2HYE C R644K *Neutral Q13705 2H62 D R22H Disease Q13813 1OWA A D152N Neutral Q13813 1OWA A N152D *Neutral Q13825 1HZD A A240V Disease Q13825 2VX2 A A69T *Neutral Q13825 2VX2 A T69A Neutral Q14114 1LRX B I468V *Neutral Q14114 1LRX B V468I Neutral Q14145 2FLU X D349N Neutral Q14145 2FLU X G364C Disease Q14145 2FLU X G430C Disease Q14145 2FLU X N349D *Neutral Q14203 1TXQ A G59S Disease Q14353 1ZX0 C A54P Disease Q14353 1ZX0 C H51P Disease Q14353 1ZX0 C M50L Disease Q14353 1ZX0 C W20S Disease Q14353 1ZX0 C C169Y Disease Q14353 1ZX0 C L197P Disease Q14353 1ZX0 C M209T *Neutral Q14353 1ZX0 C T209M Neutral Q14376 1EK6 A A25V Disease Q14376 1EK6 A D69E Disease Q14376 1EK6 A G90E Disease Q14376 1EK6 A N34S Disease Q14376 1EK6 A R40C Disease Q14376 1EK6 A V94M Disease Q14376 1EK6 A A180V Neutral Q14376 1EK6 A D103G Disease Q14376 1EK6 A E165K Disease Q14376 1EK6 A G302D Disease Q14376 1EK6 A G319E Disease Q14376 1EK6 A K257R Disease Q14376 1EK6 A L183P Disease Q14376 1EK6 A L313M Disease Q14376 1EK6 A R169W Disease Q14376 1EK6 A R239W Disease Q14376 1EK6 A R335H Disease Q14376 1EK6 A V180A *Neutral Q14653 1QWT A E377K Neutral Q14653 1QWT A K377E *Neutral Q14653 1QWT A S427T Neutral Q14653 1QWT A T427S *Neutral Q14653 2PI0 B Q96R *Neutral Q14653 2PI0 B R96Q Neutral Q14676 2ETX B Q1904R *Neutral Q14676 2ETX B R1904Q Neutral Q14691 2E9X A I97V *Neutral Q14691 2E9X A V97I Neutral Q14790 1QTN A D285H Neutral Q14790 1QTN A H285D *Neutral Q14790 1QTN A R248W Disease Q14896 1GXE A L29H Disease Q14896 1GXE A R14H Disease Q14896 1GXE A R28H Disease Q14896 1GXE A R28P Disease Q14896 1GXE A R93C Disease Q14896 1GXE A D130N Disease Q14896 1GXE A E119D Disease Q14896 1GXE A N115K Disease Q14896 2K1M A G4R Disease Q14896 2K1M A T58A Disease Q15109 1PWI A G82S Neutral Q15109 1PWI A S82G *Neutral Q15109 1PWI A Q100R Neutral Q15109 1PWI A R100Q *Neutral Q15274 2JBM A A160V Neutral Q15274 2JBM A A197T Neutral Q15274 2JBM A T197A *Neutral Q15274 2JBM A V160A *Neutral Q15276 1X79 B E640G Neutral Q15276 1X79 B G640E *Neutral Q15465 3HO5 H D88V Disease Q15465 3HO5 H A110D Disease Q15465 3HO5 H C183F Disease Q15465 3HO5 H E188Q Disease Q15465 3HO5 H H140P Disease Q15465 3HO5 H H140Q Disease Q15465 3HO5 H I111F Disease Q15465 3HO5 H I111N Disease Q15465 3HO5 H N115K Disease Q15465 3HO5 H Q100H Disease Q15465 3HO5 H T150R Disease Q15465 3HO5 H W117G Disease Q15465 3HO5 H W117R Disease Q15544 1BH9 B F155S *Neutral Q15544 1BH9 B S155F Neutral Q15582 2VXP A A546D Disease Q15582 2VXP A A546T Disease Q15582 2VXP A F540S Disease Q15582 2VXP A G623D Disease Q15582 2VXP A H572R Disease Q15582 2VXP A H626P Disease Q15582 2VXP A H626R Disease Q15582 2VXP A L509R Disease Q15582 2VXP A L518P Disease Q15582 2VXP A L518R Disease Q15582 2VXP A L527R Disease Q15582 2VXP A L569R Disease Q15582 2VXP A N622K Disease Q15582 2VXP A P551Q Disease Q15582 2VXP A R555Q Disease Q15582 2VXP A R555W Disease Q15582 2VXP A T538R Disease Q15582 2VXP A V505D Disease Q15750 2J4O A D224E Neutral Q15750 2J4O A E224D *Neutral Q15796 1DEV A D450E Disease Q15796 1DEV A L440R Disease Q15796 1DEV A P445H Disease Q15819 1J7D A D40H Neutral Q15819 1J7D A E36G Neutral Q15819 1J7D A G36E *Neutral Q15819 1J7D A H40D *Neutral Q15819 1J7D A P78Q Neutral Q15819 1J7D A Q78P *Neutral Q16288 1WWB X G309R Neutral Q16288 1WWB X N338Y Neutral Q16288 1WWB X R309G *Neutral Q16288 1WWB X Y338N *Neutral Q16288 2IFG A Q80R Neutral Q16288 2IFG A R80Q *Neutral Q16288 2IFG A G238V *Neutral Q16288 2IFG A V238G Neutral Q16539 1WBS A D343G Neutral Q16539 1WBS A G343D *Neutral Q16555 2VM8 A A118T Neutral Q16555 2VM8 A T118A *Neutral Q16568 1HY9 A L86M Neutral Q16568 1HY9 A M86L *Neutral Q16595 1EKG A C202S *Neutral Q16595 1EKG A D122Y Disease Q16595 1EKG A G130V Disease Q16595 1EKG A I154F Disease Q16595 1EKG A L106S Disease Q16595 1EKG A L182F Disease Q16595 1EKG A L198R Disease Q16595 1EKG A R165C Disease Q16595 1EKG A S202C Neutral Q16595 1EKG A W155R Disease Q16611 2IMT A A28V Neutral Q16611 2IMT A H42R *Neutral Q16611 2IMT A R42H Neutral Q16611 2IMT A R69S *Neutral Q16611 2IMT A S69R Neutral Q16611 2IMT A V28A *Neutral Q16627 2Q8R E E34K *Neutral Q16627 2Q8R E K34E Neutral Q16637 1MHN A G95R Disease Q16637 1MHN A A111G Disease Q16637 1MHN A I116F Disease Q16637 1MHN A Q136E Disease Q16665 1L8C B A119T *Neutral Q16665 1L8C B T119A Neutral Q16678 2FDV A C203R *Neutral Q16678 2FDV A D418N *Neutral Q16678 2FDV A H160L *Neutral Q16678 2FDV A K476R Neutral Q16678 2FDV A L128R *Neutral Q16678 2FDV A L160H Neutral Q16678 2FDV A N418D Neutral Q16678 2FDV A N438Y Neutral Q16678 2FDV A Q128R *Neutral Q16678 2FDV A R128L Neutral Q16678 2FDV A R128Q Neutral Q16678 2FDV A R203C Neutral Q16678 2FDV A R476K *Neutral Q16678 2FDV A Y438N *Neutral Q16678 2GEG C K98R Neutral Q16678 2GEG C R98K *Neutral Q16678 2GEG C K102R Neutral Q16678 2GEG C N493S Neutral Q16678 2GEG C R102K *Neutral Q16678 2GEG C S268T Neutral Q16678 2GEG C S493N *Neutral Q16678 2GEG C T268S *Neutral Q16678 2HI4 A D104N Neutral Q16678 2HI4 A D348N Neutral Q16678 2HI4 A E168Q Neutral Q16678 2HI4 A N104D *Neutral Q16678 2HI4 A N348D *Neutral Q16678 2HI4 A Q168E *Neutral Q16678 2HI4 A R298S *Neutral Q16678 2HI4 A R431W Neutral Q16678 2HI4 A S298R Neutral Q16678 2HI4 A W431R *Neutral Q16678 2NNJ A F269I *Neutral Q16678 2NNJ A I244V Neutral Q16678 2NNJ A I264M Neutral Q16678 2NNJ A I269F Neutral Q16678 2NNJ A K139R *Neutral Q16678 2NNJ A L390S Neutral Q16678 2NNJ A M264I *Neutral Q16678 2NNJ A R139K Neutral Q16678 2NNJ A S390L *Neutral Q16678 2NNJ A V244I *Neutral Q16678 2P85 A C257R *Neutral Q16678 2P85 A D158E Neutral Q16678 2P85 A E158D *Neutral Q16678 2P85 A R257C Neutral Q16696 2P85 A C494R *Neutral Q16696 2P85 A F453Y Neutral Q16696 2P85 A L323V *Neutral Q16696 2P85 A Q101R *Neutral Q16696 2P85 A R101Q Neutral Q16696 2P85 A R494C Neutral Q16696 2P85 A V323L Neutral Q16696 2P85 A Y453F *Neutral Q16769 1MOI A Q71R Neutral Q16769 1MOI A R54W Neutral Q16769 1MOI A R71Q *Neutral Q16769 1MOI A W54R *Neutral Q16769 1MOI A H360P Neutral Q16769 1MOI A P360H *Neutral Q16772 2VCV A D73N *Neutral Q16772 2VCV A I71L Neutral Q16772 2VCV A L71I *Neutral Q16772 2VCV A N73D Neutral Q16836 1F0Y A A28T Disease Q16836 1F0Y A D45E Disease Q16836 1F0Y A L74P *Neutral Q16836 1F0Y A P74L Neutral Q16836 1F0Y A H140Q *Neutral Q16836 1F0Y A P246L Disease Q16836 1F0Y A Q140H Neutral Q16873 2PNO A Q142R *Neutral Q16873 2PNO A R142Q Neutral Q16878 2IC1 A I45T *Neutral Q16878 2IC1 A T45I Neutral Q16881 2CFY A D215G Neutral Q16881 2CFY A G215D *Neutral Q29980 1A6Z A M31V *Neutral Q29980 1A6Z A V31M Neutral Q29980 1A6Z A E255K Neutral Q29980 1A6Z A K255E *Neutral Q29980 1AGD A A41T Neutral Q29980 1AGD A A73T *Neutral Q29980 1AGD A F67S Neutral Q29980 1AGD A K63N *Neutral Q29980 1AGD A L95W Neutral Q29980 1AGD A N63K Neutral Q29980 1AGD A N77S *Neutral Q29980 1AGD A R97S *Neutral Q29980 1AGD A S67F *Neutral Q29980 1AGD A S77N Neutral Q29980 1AGD A S97R Neutral Q29980 1AGD A S97T Neutral Q29980 1AGD A T41A *Neutral Q29980 1AGD A T73A Neutral Q29980 1AGD A T97S *Neutral Q29980 1AGD A W95L *Neutral Q29980 1AGD A D114N *Neutral Q29980 1AGD A D156L Neutral Q29980 1AGD A D156R Neutral Q29980 1AGD A L156D *Neutral Q29980 1AGD A N114D Neutral Q29980 1AGD A R156D *Neutral Q29980 1EFX A K66N Neutral Q29980 1EFX A N66K *Neutral Q29980 1EFX A R97S Neutral Q29980 1EFX A S97R *Neutral Q29980 1EFX A L103V *Neutral Q29980 1EFX A M248V *Neutral Q29980 1EFX A V103L Neutral Q29980 1EFX A V248M Neutral Q29980 1HSB A H70Q *Neutral Q29980 1HSB A M12V *Neutral Q29980 1HSB A M97R Neutral Q29980 1HSB A Q70H Neutral Q29980 1HSB A R97M *Neutral Q29980 1HSB A V12M Neutral Q29980 1HSB A D116V Neutral Q29980 1HSB A D116Y Neutral Q29980 1HSB A F109L Neutral Q29980 1HSB A L109F *Neutral Q29980 1HSB A P105S *Neutral Q29980 1HSB A S105P Neutral Q29980 1HSB A V116D *Neutral Q29980 1HSB A Y116D *Neutral Q29980 1M6O A A41T *Neutral Q29980 1M6O A D61E Neutral Q29980 1M6O A E61D *Neutral Q29980 1M6O A E63N Neutral Q29980 1M6O A N63E *Neutral Q29980 1M6O A N77S Neutral Q29980 1M6O A S77N *Neutral Q29980 1M6O A T41A Neutral Q29980 1M6O A D156R Neutral Q29980 1M6O A R156D *Neutral Q29980 1QQD A A11S *Neutral Q29980 1QQD A A73T Neutral Q29980 1QQD A K66N Neutral Q29980 1QQD A L28V *Neutral Q29980 1QQD A M52V *Neutral Q29980 1QQD A N66K *Neutral Q29980 1QQD A S11A Neutral Q29980 1QQD A T73A *Neutral Q29980 1QQD A V28L Neutral Q29980 1QQD A V52M Neutral Q29980 1QQD A E177K Neutral Q29980 1QQD A K177E *Neutral Q29980 1QQD A L156R *Neutral Q29980 1QQD A M248V *Neutral Q29980 1QQD A R156L Neutral Q29980 1QQD A V248M Neutral Q29980 1X7Q A E19K Neutral Q29980 1X7Q A H70Q *Neutral Q29980 1X7Q A K19E *Neutral Q29980 1X7Q A Q70H Neutral Q29980 1X7Q A H151R Neutral Q29980 1X7Q A R151H *Neutral Q29980 1X7Q A R163T Neutral Q29980 1X7Q A T163R *Neutral Q29980 1XH3 A D74Y *Neutral Q29980 1XH3 A D83G *Neutral Q29980 1XH3 A F67S Neutral Q29980 1XH3 A G16V Neutral Q29980 1XH3 A G83D Neutral Q29980 1XH3 A R97S Neutral Q29980 1XH3 A S67F *Neutral Q29980 1XH3 A S97R *Neutral Q29980 1XH3 A V16G *Neutral Q29980 1XH3 A Y74D Neutral Q29980 1XH3 A L103V Neutral Q29980 1XH3 A L156R Neutral Q29980 1XH3 A R156L *Neutral Q29980 1XH3 A S116Y Neutral Q29980 1XH3 A V103L *Neutral Q29980 1XH3 A Y116S *Neutral Q29980 1XR9 A C67S *Neutral Q29980 1XR9 A L95W Neutral Q29980 1XR9 A S67C Neutral Q29980 1XR9 A W95L *Neutral Q29980 1XR9 A H113Y Neutral Q29980 1XR9 A L250P *Neutral Q29980 1XR9 A P250L Neutral Q29980 1XR9 A Y113H *Neutral Q29980 2A83 A H59Y *Neutral Q29980 2A83 A Y59H Neutral Q29980 2A83 A A211G Neutral Q29980 2A83 A D114H *Neutral Q29980 2A83 A D116H Neutral Q29980 2A83 A E152V *Neutral Q29980 2A83 A G211A *Neutral Q29980 2A83 A H114D Neutral Q29980 2A83 A H116D *Neutral Q29980 2A83 A V152E Neutral Q29980 2RFX A R97V *Neutral Q29980 2RFX A V97R Neutral Q29980 2RFX A D114N Neutral Q29980 2RFX A L103V *Neutral Q29980 2RFX A L156R Neutral Q29980 2RFX A N114D *Neutral Q29980 2RFX A R156L *Neutral Q29980 2RFX A V103L Neutral Q29980 3BO8 A A76E Neutral Q29980 3BO8 A E76A *Neutral Q29980 3BO8 A G56R Neutral Q29980 3BO8 A G65R *Neutral Q29980 3BO8 A M67V Neutral Q29980 3BO8 A R17S Neutral Q29980 3BO8 A R56G *Neutral Q29980 3BO8 A R65G Neutral Q29980 3BO8 A S17R *Neutral Q29980 3BO8 A V67M *Neutral Q29980 3BO8 A F109L Neutral Q29980 3BO8 A H145R *Neutral Q29980 3BO8 A H181R *Neutral Q29980 3BO8 A I142T Neutral Q29980 3BO8 A L109F *Neutral Q29980 3BO8 A R145H Neutral Q29980 3BO8 A R181H Neutral Q29980 3BO8 A T142I *Neutral Q29980 3D25 A F9Y Neutral Q29980 3D25 A Y9F *Neutral Q29980 3D25 A C99Y *Neutral Q29980 3D25 A D30N Neutral Q29980 3D25 A I73T *Neutral Q29980 3D25 A K66N Neutral Q29980 3D25 A N30D *Neutral Q29980 3D25 A N66K *Neutral Q29980 3D25 A Q43R Neutral Q29980 3D25 A R43Q *Neutral Q29980 3D25 A T73I Neutral Q29980 3D25 A Y99C Neutral Q29980 3D25 A E163T *Neutral Q29980 3D25 A G167W *Neutral Q29980 3D25 A L156Q Neutral Q29980 3D25 A L156W Neutral Q29980 3D25 A Q156L *Neutral Q29980 3D25 A T163E Neutral Q29980 3D25 A W156L *Neutral Q29980 3D25 A W167G Neutral Q30154 1FV1 B H33N *Neutral Q30154 1FV1 B K12T Neutral Q30154 1FV1 B N33H Neutral Q30154 1FV1 B T12K *Neutral Q30154 1FV1 B A125G *Neutral Q30154 1FV1 B G125A Neutral Q30201 1A6Z A G21D Disease Q30201 1A6Z A G71R Disease Q30201 1A6Z A H41D Disease Q30201 1A6Z A I83T Disease Q30201 1A6Z A M37V *Neutral Q30201 1A6Z A R44C Disease Q30201 1A6Z A S43C Disease Q30201 1A6Z A V37M Neutral Q30201 1A6Z A A154V Disease Q30201 1A6Z A C260Y Disease Q30201 1A6Z A I195T *Neutral Q30201 1A6Z A Q105H Disease Q30201 1A6Z A Q261P Disease Q30201 1A6Z A R202G Disease Q30201 1A6Z A T195I Neutral Q30201 1A6Z A V273A Disease Q460N3 3BLJ B A499T Neutral Q460N3 3BLJ B G606R Neutral Q460N3 3BLJ B R606G *Neutral Q460N3 3BLJ B T499A *Neutral Q49A26 2UYY A C531Y *Neutral Q49A26 2UYY A H459Q *Neutral Q49A26 2UYY A Q459H Neutral Q49A26 2UYY A Y531C Neutral Q5TFQ8 2JJV B I22T *Neutral Q5TFQ8 2JJV B T22I Neutral Q658P3 2VNS A A184T Neutral Q658P3 2VNS A T184A *Neutral Q6UWM7 2E9L A I172M *Neutral Q6UWM7 2E9L A M172I Neutral Q6UWM7 2E9L A P213R *Neutral Q6UWM7 2E9L A R213P Neutral Q7Z406 1IK2 A A3D *Neutral Q7Z406 1IK2 A D3A Neutral Q7Z406 1IK2 A D107E Neutral Q7Z406 1IK2 A E107D *Neutral Q86SX6 2WEM A A146T Neutral Q86SX6 2WEM A T146A *Neutral Q86WS5 1BIO A I238M Neutral Q86WS5 1BIO A M238I *Neutral Q86WS5 1FQ3 A H245Y *Neutral Q86WS5 1FQ3 A Y245H Neutral Q86WS5 2BDG A D147G *Neutral Q86WS5 2BDG A G147D Neutral Q86WS5 2BDG A H186AQ *Neutral Q86WS5 2BDG A Q186AH Neutral Q86WS5 2Z7F E L85V *Neutral Q86WS5 2Z7F E V85L Neutral Q86WS5 2Z7F E I216V *Neutral Q86WS5 2Z7F E V216I Neutral Q86WS5 2ZCH P I114L *Neutral Q86WS5 2ZCH P L114I Neutral Q8IU85 2A27 B R50W Neutral Q8IU85 2A27 B W50R *Neutral Q8N1Q1 3CZV A N67S Neutral Q8N1Q1 3CZV A S67N *Neutral Q8N335 2PLA A E83K Disease Q8N335 2PLA A A280V Disease Q8N335 2PLA A F178L *Neutral Q8N335 2PLA A I124V Disease Q8N335 2PLA A L178F Neutral Q8N335 2PLA A R273C Disease Q8N3C7 2Z0W A L12R *Neutral Q8N3C7 2Z0W A R12L Neutral Q8N3T1 2FFU A H245R *Neutral Q8N3T1 2FFU A R245H Neutral Q8NBJ7 1Y4J B D51E *Neutral Q8NBJ7 1Y4J B E51D Neutral Q8NI22 2VRG A D129E Disease Q8NI22 2VRG A I136T Disease Q8TCD5 2I7D A L68P *Neutral Q8TCD5 2I7D A P68L Neutral Q8TF76 3F2N A M706V Neutral Q8TF76 3F2N A V706M *Neutral Q8WUM4 3C3R A A309T Neutral Q8WUM4 3C3R A T309A *Neutral Q8WXE9 2JXC B P307S *Neutral Q8WXE9 2JXC B S307P Neutral Q8WZ42 1TKI A I94V *Neutral Q8WZ42 1TKI A V94I Neutral Q8WZ42 1TKI A H127Q *Neutral Q8WZ42 1TKI A H169R *Neutral Q8WZ42 1TKI A Q127H Neutral Q8WZ42 1TKI A R169H Neutral Q8WZ42 1TNM A K80Q Neutral Q8WZ42 1TNM A M48V *Neutral Q8WZ42 1TNM A Q80K *Neutral Q8WZ42 1TNM A V48M Neutral Q8WZ42 2A38 A D60Y Neutral Q8WZ42 2A38 A V54M Disease Q8WZ42 2A38 A Y60D *Neutral Q92466 3EI4 B A293T Neutral Q92466 3EI4 B K244E Disease Q92466 3EI4 B M215T Neutral Q92466 3EI4 B R273H Disease Q92466 3EI4 B T215M *Neutral Q92466 3EI4 B T293A *Neutral Q92529 1N3H A A95V Neutral Q92529 1N3H A V95A *Neutral Q92583 1NR4 E M44V *Neutral Q92583 1NR4 E V44M Neutral Q92600 2FV2 C I127T Neutral Q92600 2FV2 C T127I *Neutral Q92730 2CLS A P44R Neutral Q92730 2CLS A R44P *Neutral Q92793 3DWY A Y1175C Disease Q92820 1L9X A A7T Neutral Q92820 1L9X A T7A *Neutral Q92820 1L9X A I127T *Neutral Q92820 1L9X A T127I Neutral Q92838 1RJ7 E A349T Disease Q92838 1RJ7 E A356D Disease Q92838 1RJ7 E C332Y Disease Q92838 1RJ7 E D298H Disease Q92838 1RJ7 E D298Y Disease Q92838 1RJ7 E F302S Disease Q92838 1RJ7 E G255C Disease Q92838 1RJ7 E G255D Disease Q92838 1RJ7 E G269V Disease Q92838 1RJ7 E G291R Disease Q92838 1RJ7 E G291W Disease Q92838 1RJ7 E G299S Disease Q92838 1RJ7 E H252L Disease Q92838 1RJ7 E H252Y Disease Q92838 1RJ7 E I360N Disease Q92838 1RJ7 E M373I Disease Q92838 1RJ7 E N372D Disease Q92838 1RJ7 E Q306H Disease Q92838 1RJ7 E Q358E Disease Q92838 1RJ7 E R357P Disease Q92838 1RJ7 E S374R Disease Q92838 1RJ7 E T378M Disease Q92838 1RJ7 E T378P Disease Q92838 1RJ7 E V307G Disease Q92838 1RJ7 E W274G Disease Q92838 1RJ7 E Y320C Disease Q92838 1RJ7 E Y343C Disease Q92882 1ZLM A N48S Neutral Q92882 1ZLM A S48N *Neutral Q92889 2A1J A A849D Neutral Q92889 2A1J A D849A *Neutral Q92889 2A1J A E864G Neutral Q92889 2A1J A G864E *Neutral Q92889 2A1J A I862V Neutral Q92889 2A1J A V862I *Neutral Q92913 3HBW A K197Q Neutral Q92913 3HBW A Q197K *Neutral Q92947 1SIQ A A78V Disease Q92947 1SIQ A C71Y Disease Q92947 1SIQ A G57R Disease Q92947 1SIQ A R44C Disease Q92947 1SIQ A R50L Disease Q92947 1SIQ A R84G Disease Q92947 1SIQ A R94G Disease Q92947 1SIQ A S95L Disease Q92947 1SIQ A A151T Disease Q92947 1SIQ A A249T Disease Q92947 1SIQ A A254T Neutral Q92947 1SIQ A A254V Neutral Q92947 1SIQ A A305T Disease Q92947 1SIQ A A338T Disease Q92947 1SIQ A A377T Disease Q92947 1SIQ A A377V Disease Q92947 1SIQ A A389E Disease Q92947 1SIQ A C264S Disease Q92947 1SIQ A C331R Disease Q92947 1SIQ A E321K Disease Q92947 1SIQ A E370K Disease Q92947 1SIQ A F192L Disease Q92947 1SIQ A G134R Disease Q92947 1SIQ A G310R Disease Q92947 1SIQ A G310S Disease Q92947 1SIQ A G346A Disease Q92947 1SIQ A G346R Disease Q92947 1SIQ A H359R Disease Q92947 1SIQ A L135R Disease Q92947 1SIQ A L239P Disease Q92947 1SIQ A L265W Disease Q92947 1SIQ A L363P Disease Q92947 1SIQ A M147T Disease Q92947 1SIQ A M222V Disease Q92947 1SIQ A N348D Disease Q92947 1SIQ A N362K Disease Q92947 1SIQ A P234S Disease Q92947 1SIQ A Q289E Disease Q92947 1SIQ A R117Q Disease Q92947 1SIQ A R183P Disease Q92947 1SIQ A R213Q Disease Q92947 1SIQ A R213W Disease Q92947 1SIQ A R250W Disease Q92947 1SIQ A R269W Disease Q92947 1SIQ A R311C Disease Q92947 1SIQ A R311H Disease Q92947 1SIQ A R339C Disease Q92947 1SIQ A R339H Disease Q92947 1SIQ A R342Q Disease Q92947 1SIQ A R358Q Disease Q92947 1SIQ A R358W Disease Q92947 1SIQ A S261L Disease Q92947 1SIQ A T254A *Neutral Q92947 1SIQ A T372I Disease Q92947 1SIQ A T385M Disease Q92947 1SIQ A V104I Disease Q92947 1SIQ A V254A *Neutral Q92947 1SIQ A V356M Disease Q92947 1SIQ A Y251H Disease Q92947 2JIF A I316V Neutral Q92947 2JIF A V316I *Neutral Q969H0 2OVQ B G2668S *Neutral Q969H0 2OVQ B R2465C Disease Q969H0 2OVQ B R2505L Disease Q969H0 2OVQ B S2668G Neutral Q969S2 1VZP A L257R *Neutral Q969S2 1VZP A P304T Neutral Q969S2 1VZP A R257L Neutral Q969S2 1VZP A T304P *Neutral Q96C23 1SNZ B N190Y Neutral Q96C23 1SNZ B Y190N *Neutral Q96C24 3FDW A I420V *Neutral Q96C24 3FDW A V420I Neutral Q96DC8 2VX2 A A151T *Neutral Q96DC8 2VX2 A D162N Neutral Q96DC8 2VX2 A N162D *Neutral Q96DC8 2VX2 A T151A Neutral Q96FE5 2ID5 B F144S *Neutral Q96FE5 2ID5 B S144F Neutral Q96G91 2B6S A A95T Neutral Q96G91 2B6S A T95A *Neutral Q96HD9 2O4H A C310G Neutral Q96HD9 2O4H A G310C *Neutral Q96KQ7 2O8J B F1165Y *Neutral Q96KQ7 2O8J B Y1165F Neutral Q96PD4 1JPY A E96G Neutral Q96PD4 1JPY A G96E *Neutral Q96PD4 1JPY A I125V *Neutral Q96PD4 1JPY A V125I Neutral Q96RG2 3DLS A C1266F *Neutral Q96RG2 3DLS A F1266C Neutral Q96RG2 3DLS A M1210V *Neutral Q96RG2 3DLS A V1210M Neutral Q96RQ9 2I8H _ A509S Neutral Q96RQ9 2I8H _ S509A *Neutral Q96RS0 3GDH A C754F *Neutral Q96RS0 3GDH A F754C Neutral Q99062 1AZ7 A D196N Neutral Q99062 1AZ7 A M107T Neutral Q99062 1AZ7 A N196D *Neutral Q99062 1AZ7 A T107M *Neutral Q99497 1P5F A E64D Disease Q99497 1P5F A M26I Disease Q99497 1P5F A Q98R *Neutral Q99497 1P5F A R98Q Neutral Q99497 1P5F A A104T Disease Q99497 1P5F A A171S Neutral Q99497 1P5F A D149A Disease Q99497 1P5F A E163K Neutral Q99497 1P5F A G150S Neutral Q99497 1P5F A K163E *Neutral Q99497 1P5F A L166P Disease Q99497 1P5F A S150G *Neutral Q99497 1P5F A S171A *Neutral Q99536 1YB5 A E183K Neutral Q99536 1YB5 A I176V Neutral Q99536 1YB5 A K183E *Neutral Q99536 1YB5 A V176I *Neutral Q99616 2RA4 A N6S Neutral Q99616 2RA4 A S6N *Neutral Q99638 3GGR A C3F Neutral Q99638 3GGR A F3C *Neutral Q99638 3GGR A L71Q Neutral Q99638 3GGR A Q71L *Neutral Q99638 3GGR A A100S *Neutral Q99638 3GGR A H239R Neutral Q99638 3GGR A R239H *Neutral Q99638 3GGR A S100A Neutral Q99714 1F67 A L122V Disease Q99714 1F67 A N247S Disease Q99714 1F67 A R130C Disease Q99728 2NTE A C645R Neutral Q99728 2NTE A C658R *Neutral Q99728 2NTE A F728S *Neutral Q99728 2NTE A R645C *Neutral Q99728 2NTE A R658C Neutral Q99728 2NTE A S728F Neutral Q99728 2NTE A S761N Disease Q99728 2NTE A V695L Disease Q99828 1Y1A A I106T Neutral Q99828 1Y1A A T106I *Neutral Q99836 2Z5V A R49C Disease Q9BPV8 2B6U A M158T Neutral Q9BPV8 2B6U A T158M *Neutral Q9BRG1 3CUQ C I76V Neutral Q9BRG1 3CUQ C V76I *Neutral Q9BRR9 2P0H A A370S *Neutral Q9BRR9 2P0H A S370A Neutral Q9BSD7 2I3B A E105G *Neutral Q9BSD7 2I3B A G105E Neutral Q9BV79 2VCY A F96L *Neutral Q9BV79 2VCY A L96F Neutral Q9BV79 2VCY A K227R *Neutral Q9BV79 2VCY A L258R *Neutral Q9BV79 2VCY A R227K Neutral Q9BV79 2VCY A R258L Neutral Q9BXK5 2IPD _ I46R Neutral Q9BXK5 2IPD _ I46T Neutral Q9BXK5 2IPD _ I55V Neutral Q9BXK5 2IPD _ R46I *Neutral Q9BXK5 2IPD _ T46I *Neutral Q9BXK5 2IPD _ V55I *Neutral Q9BXK5 2IPD _ P360S Neutral Q9BXK5 2IPD _ S360P *Neutral Q9BY32 2CAR B P32T Disease Q9BY49 1YXM A E149K Neutral Q9BY49 1YXM A F297L Neutral Q9BY49 1YXM A K149E *Neutral Q9BY49 1YXM A L297F *Neutral Q9BY84 2VSW A M23T *Neutral Q9BY84 2VSW A T23M Neutral Q9BYF1 1R42 A K26R Neutral Q9BYF1 1R42 A R26K *Neutral Q9BYJ1 2ABT A A460P Neutral Q9BYJ1 2ABT A G101V Neutral Q9BYJ1 2ABT A K102N *Neutral Q9BYJ1 2ABT A M238V *Neutral Q9BYJ1 2ABT A N102K Neutral Q9BYJ1 2ABT A P460A *Neutral Q9BYJ1 2ABT A Q204R *Neutral Q9BYJ1 2ABT A R204Q Neutral Q9BYJ1 2ABT A V101G *Neutral Q9BYJ1 2ABT A V238M Neutral Q9BZP6 1HJX A G145R *Neutral Q9BZP6 1HJX A R145G Neutral Q9BZP6 1WB0 A H40R *Neutral Q9BZP6 1WB0 A R40H Neutral Q9BZP6 1WB0 A G102S Neutral Q9BZP6 1WB0 A S102G *Neutral Q9GIY3 2WBJ F F67I *Neutral Q9GIY3 2WBJ F G86V *Neutral Q9GIY3 2WBJ F I67F Neutral Q9GIY3 2WBJ F V86G Neutral Q9GIY3 2WBJ F A140T Neutral Q9GIY3 2WBJ F T140A *Neutral Q9GZT9 2G19 A P317R Disease Q9GZT9 2G19 A R371H Disease Q9GZV9 2P39 A S71G Disease Q9GZX6 1M4R A G158S *Neutral Q9GZX6 1M4R A S158G Neutral Q9H0F7 2H57 B T31M Disease Q9H0F7 2H57 B T31R Disease Q9H0F7 2H57 B G169A Disease Q9H0F7 2H57 B L170W Disease Q9H0P0 2VKQ A D87V Disease Q9H0P0 2VKQ A G230R Disease Q9H0P0 2VKQ A L131P Disease Q9H0P0 2VKQ A N179S Disease Q9H227 2E9L A C354R Neutral Q9H227 2E9L A D106N Neutral Q9H227 2E9L A N106D *Neutral Q9H227 2E9L A R354C *Neutral Q9H244 1T78 A R256Q Disease Q9H244 1T78 A R265W Disease Q9H2H8 2OK3 A D146E Neutral Q9H2H8 2OK3 A E146D *Neutral Q9H2X3 1XAR A C251Y *Neutral Q9H2X3 1XAR A Y251C Neutral Q9H2X3 1XPH A D291N Neutral Q9H2X3 1XPH A N291D *Neutral Q9H2X3 1Z0Y A C205Y *Neutral Q9H2X3 1Z0Y A Y205C Neutral Q9H3D4 1RG6 A C22G Disease Q9H3D4 1RG6 A D64H Neutral Q9H3D4 1RG6 A H64D *Neutral Q9H3D4 1RG6 A I10T Disease Q9H3D4 1RG6 A L14F Disease Q9H3D4 1RG6 A S21A Disease Q9H3D4 1RG6 A S41P Disease Q9H4Y5 1EEM A C86S *Neutral Q9H4Y5 1EEM A S86C Neutral Q9HBL8 2WM3 A I23T *Neutral Q9HBL8 2WM3 A T23I Neutral Q9HBL8 2WM3 A L252P *Neutral Q9HBL8 2WM3 A P252L Neutral Q9HC16 3E1U A E275Q *Neutral Q9HC16 3E1U A H256R *Neutral Q9HC16 3E1U A Q275E Neutral Q9HC16 3E1U A R256H Neutral Q9NNW7 1ZMD E K69T *Neutral Q9NNW7 1ZMD E T69K Neutral Q9NNW7 3DK9 A H270P *Neutral Q9NNW7 3DK9 A I217V Neutral Q9NNW7 3DK9 A P270H Neutral Q9NNW7 3DK9 A V217I *Neutral Q9NNX6 1SL4 A A382S Neutral Q9NNX6 1SL4 A S382A *Neutral Q9NNX6 1Z0Y A Q164R *Neutral Q9NNX6 1Z0Y A R164Q Neutral Q9NP95 3F1R A A175P *Neutral Q9NP95 3F1R A D206N Neutral Q9NP95 3F1R A G116R Neutral Q9NP95 3F1R A N206D *Neutral Q9NP95 3F1R A P175A Neutral Q9NP95 3F1R A R116G *Neutral Q9NP97 1Z09 A F71I *Neutral Q9NP97 1Z09 A I71F Neutral Q9NP97 1Z09 A R13S *Neutral Q9NP97 1Z09 A S13R Neutral Q9NP99 1SMO A S25T *Neutral Q9NP99 1SMO A T25S Neutral Q9NS18 2HT9 B E55K *Neutral Q9NS18 2HT9 B K55E Neutral Q9NTG7 3GLR A G369S Neutral Q9NTG7 3GLR A I208V *Neutral Q9NTG7 3GLR A S369G *Neutral Q9NTG7 3GLR A V208I Neutral Q9NVS9 1NRG A E50K Neutral Q9NVS9 1NRG A K50E *Neutral Q9NVS9 1NRG A Q116R *Neutral Q9NVS9 1NRG A R116Q Neutral Q9NVS9 1NRG A R229W Disease Q9NWT6 1YCI A A41P *Neutral Q9NWT6 1YCI A P41A Neutral Q9P2T1 2A7R A D242G *Neutral Q9P2T1 2A7R A G242D Neutral Q9UBC3 3FLG A S66P Disease Q9UBQ7 2GCG A Q170R *Neutral Q9UBQ7 2GCG A R170Q Neutral Q9UBR2 1EF7 A A225T Neutral Q9UBR2 1EF7 A T225A *Neutral Q9UBT2 2PX9 A L307R Neutral Q9UBT2 2PX9 A R307L *Neutral Q9UBU3 1P7X A L72M Neutral Q9UBU3 1P7X A L90Q *Neutral Q9UBU3 1P7X A M72L *Neutral Q9UBU3 1P7X A Q90L Neutral Q9UGP5 2BCQ A R438W Neutral Q9UGP5 2BCQ A W438R *Neutral Q9UI42 2BO9 A L71R *Neutral Q9UI42 2BO9 A P46T Neutral Q9UI42 2BO9 A R71L Neutral Q9UI42 2BO9 A T46P *Neutral Q9UI42 2BO9 A C191G *Neutral Q9UI42 2BO9 A G191C Neutral Q9UII6 2GWO C Q62R *Neutral Q9UII6 2GWO C R62Q Neutral Q9UII6 2GWO C C156Y Neutral Q9UII6 2GWO C G190R *Neutral Q9UII6 2GWO C R190G Neutral Q9UII6 2GWO C Y156C *Neutral Q9UIK4 2A27 B R261W Neutral Q9UIK4 2A27 B W261R *Neutral Q9UJ70 2CH6 A A60V Neutral Q9UJ70 2CH6 A R38W *Neutral Q9UJ70 2CH6 A V60A *Neutral Q9UJ70 2CH6 A W38R Neutral Q9UJ71 3BC7 A A278V *Neutral Q9UJ71 3BC7 A A300P Neutral Q9UJ71 3BC7 A D288N *Neutral Q9UJ71 3BC7 A N288D Neutral Q9UJ71 3BC7 A P213S Neutral Q9UJ71 3BC7 A P300A *Neutral Q9UJ71 3BC7 A S213P *Neutral Q9UJ71 3BC7 A V278A Neutral Q9UK53 2QIC A C215S Disease Q9UK53 2QIC A N216S Disease Q9UK55 3F1S A G40S *Neutral Q9UK55 3F1S A S40G Neutral Q9UK55 3F1S A G118R Neutral Q9UK55 3F1S A H175R *Neutral Q9UK55 3F1S A R118G *Neutral Q9UK55 3F1S A R175H Neutral Q9UKK9 2DSC A I123T Neutral Q9UKK9 2DSC A T123I *Neutral Q9UKL6 1LN1 A A10E *Neutral Q9UKL6 1LN1 A E10A Neutral Q9UKU7 1RX0 A A298T Disease Q9UKU7 1RX0 A D112Y Disease Q9UKU7 1RX0 A G115R Disease Q9UKU7 1RX0 A M106I Disease Q9UKU7 1RX0 A M130T Disease Q9UKU7 1RX0 A Q363R Disease Q9UKU7 1RX0 A R280Q Disease Q9UKU7 1RX0 A R312C Disease Q9UKU7 1RX0 A V181I Disease Q9UKY0 1LG4 A F70L Neutral Q9UKY0 1LG4 A L56P *Neutral Q9UKY0 1LG4 A L70F *Neutral Q9UKY0 1LG4 A P56L Neutral Q9UKY0 1LG4 A L149S Neutral Q9UKY0 1LG4 A S149L *Neutral Q9UMQ6 2P0R A D164N Neutral Q9UMQ6 2P0R A H327Q Neutral Q9UMQ6 2P0R A I234T Neutral Q9UMQ6 2P0R A N164D *Neutral Q9UMQ6 2P0R A Q327H *Neutral Q9UMQ6 2P0R A R122S *Neutral Q9UMQ6 2P0R A S122R Neutral Q9UMQ6 2P0R A T234I *Neutral Q9UMR2 3FHT A L149V *Neutral Q9UMR2 3FHT A V149L Neutral Q9UNA4 1T3N A G71R *Neutral Q9UNA4 1T3N A R71G Neutral Q9UNA4 1T3N A E251K Neutral Q9UNA4 1T3N A I236M Neutral Q9UNA4 1T3N A K251E *Neutral Q9UNA4 1T3N A M236I *Neutral Q9UNF0 3HAJ A I295M *Neutral Q9UNF0 3HAJ A M295I Neutral Q9UNF0 3HAJ A N176S Neutral Q9UNF0 3HAJ A S176N *Neutral Q9Y233 1LRB A D207N Neutral Q9Y233 1LRB A K206R *Neutral Q9Y233 1LRB A N207D *Neutral Q9Y233 1LRB A R206K Neutral Q9Y279 2ICC A R89W Neutral Q9Y279 2ICC A W89R *Neutral Q9Y2U5 2NPT D I110V Neutral Q9Y2U5 2NPT D V110I *Neutral Q9Y2Y0 3DOF B E87K Neutral Q9Y2Y0 3DOF B K87E *Neutral Q9Y337 2PSX A D102N Neutral Q9Y337 2PSX A N102D *Neutral Q9Y3C6 1XWN A C36S Neutral Q9Y3C6 1XWN A S36C *Neutral Q9Y3C8 2Z6O A C90Y *Neutral Q9Y3C8 2Z6O A Y90C Neutral Q9Y468 1OZ2 A I479M Neutral Q9Y468 1OZ2 A M479I *Neutral Q9Y5T5 2I50 A H124Q *Neutral Q9Y5T5 2I50 A Q124H Neutral Q9Y5Y6 1EAX A G216R Disease Q9Y6D9 1GO4 G E511K Neutral Q9Y6D9 1GO4 G E516K Disease Q9Y6D9 1GO4 G E569K Disease Q9Y6D9 1GO4 G K511E *Neutral Q9Y6D9 1GO4 G M500T *Neutral Q9Y6D9 1GO4 G R556C Disease Q9Y6D9 1GO4 G R556H Disease Q9Y6D9 1GO4 G R558H Disease Q9Y6D9 1GO4 G R572H Disease Q9Y6D9 1GO4 G T500M Neutral Q9Y6K9 3BRV D E57K Disease Q9Y6K9 3CL3 D L227P Disease Q9Y6K9 3FX0 B A1288G Disease Q9Y6K9 3FX0 B A1323P Disease Q9Y6K9 3FX0 B D1311N Disease Q9Y6K9 3FX0 B E1315A Disease Q9Y6K9 3FX0 B R1319Q Disease Q9Y6Y9 2E56 A G56R Neutral Q9Y6Y9 2E56 A R56G *Neutral Q9Y6Y9 2E56 A P157S Neutral Q9Y6Y9 2E56 A S157P *Neutral * Reverse neutral mutations