Meta-SNP: Meta-predictor of disease causing variants
  Cite: Capriotti et al. BMC Genomics 2013. Suppl 3:S2.
  WEB: http://snps.biofold.org/meta-snp


  Sequence File: SP.seq

  Mutation   PANTHER   PhD-SNP      SIFT      SNAP  Meta-SNP   RI   Profile
     M118I        NA   Neutral        NA   Neutral   Neutral    6   F[M]=71%  F[I]=0%   Nali=6
                   -     0.345         -     0.280     0.189
     Y545S   Disease   Neutral   Neutral   Neutral   Disease    2   F[Y]=13%  F[S]=8%   Nali=3357
               0.759     0.329     0.070     0.420     0.584
     L648Q   Disease   Disease   Disease   Disease   Disease    3   F[L]=46%  F[Q]=1%   Nali=2766
               0.778     0.777     0.000     0.555     0.639


  Mutation: WT+POS+NEW
    WT: Residue in wild-type protein
    POS: Residue position
    NEW: New residue after mutation
  Prediction:
    Neutral: Neutral variants
    Disease: Disease causing variants
  Outputs: Value reported under each prediction
    PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    PhD-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    SIFT: Positive Value (If >0.05 mutation is predicted Neutral)
    SNAP: Output normailzed between 0 and 1 (If >0.5 mutation is predicted Disease)
    Meta-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
  RI: Reliability Index between 0 an 10
  F[X]: Frequency of residue X in the sequence profile
  Nali: Number of aligned sequences in the mutated site