Meta-SNP: Meta-predictor of disease causing variants
  Cite: Capriotti et al. BMC Genomics 2013. Suppl 3:S2.
  WEB: http://snps.biofold.org/meta-snp


  Sequence File: IL23R_HUMAN.seq

  Mutation   PANTHER   PhD-SNP      SIFT      SNAP  Meta-SNP   RI   Profile
      W35C        NA   Disease   Disease   Disease   Disease    3   F[W]=43%  F[C]=0%   Nali=27
                   -     0.599     0.000     0.760     0.670
      S49Y        NA   Disease   Disease   Disease   Disease    3   F[S]=47%  F[Y]=0%   Nali=35
                   -     0.502     0.000     0.645     0.646
      C52F        NA   Disease   Disease   Disease   Disease    5   F[C]=100% F[F]=0%   Nali=35
                   -     0.864     0.000     0.760     0.741
      C59R        NA   Disease   Disease   Disease   Disease    0   F[C]=67%  F[R]=6%   Nali=35
                   -     0.764     0.000     0.755     0.507
      L64P        NA   Disease   Disease   Disease   Disease    3   F[L]=53%  F[P]=0%   Nali=33
                   -     0.701     0.000     0.615     0.673
     P220S   Neutral   Disease        NA   Disease   Disease    3   F[P]=93%  F[S]=0%   Nali=43
               0.360     0.685         -     0.540     0.640
     P220T   Neutral   Disease        NA   Disease   Disease    2   F[P]=93%  F[T]=0%   Nali=43
               0.421     0.632         -     0.530     0.587
     W242C   Disease   Disease        NA   Disease   Disease    4   F[W]=88%  F[C]=0%   Nali=39
               0.727     0.760         -     0.745     0.722
     C253R   Disease   Disease        NA   Disease   Disease    4   F[C]=49%  F[R]=0%   Nali=42
               0.539     0.516         -     0.740     0.711
     L284W   Disease   Disease        NA   Disease   Disease    4   F[L]=100% F[W]=0%   Nali=44
               0.808     0.739         -     0.650     0.688
     C296R   Disease   Disease   Neutral   Disease   Disease    4   F[C]=73%  F[R]=0%   Nali=44
               0.673     0.881     0.200     0.620     0.701
     W307G   Disease   Disease   Neutral   Disease   Disease    4   F[W]=100% F[G]=0%   Nali=43
               0.637     0.770     0.560     0.645     0.682
     W395R   Disease   Disease   Neutral   Disease   Disease    3   F[W]=100% F[R]=0%   Nali=16
               0.663     0.818     0.100     0.565     0.662
     P401S   Neutral   Disease   Neutral   Neutral   Disease    0   F[P]=100% F[S]=0%   Nali=16
               0.495     0.656     0.380     0.430     0.522


  Mutation: WT+POS+NEW
    WT: Residue in wild-type protein
    POS: Residue position
    NEW: New residue after mutation
  Prediction:
    Neutral: Neutral variants
    Disease: Disease causing variants
  Outputs: Value reported under each prediction
    PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    PhD-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    SIFT: Positive Value (If >0.05 mutation is predicted Neutral)
    SNAP: Output normailzed between 0 and 1 (If >0.5 mutation is predicted Disease)
    Meta-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
  RI: Reliability Index between 0 an 10
  F[X]: Frequency of residue X in the sequence profile
  Nali: Number of aligned sequences in the mutated site