Meta-SNP: Meta-predictor of disease causing variants
  Cite: Capriotti et al. BMC Genomics 2013. Suppl 3:S2.
  WEB: http://snps.biofold.org/meta-snp


  Sequence File: WP_000227942.1.seq

  Mutation   PANTHER   PhD-SNP      SIFT      SNAP  Meta-SNP   RI   Profile
     A149T        NA   Neutral        NA        NA   Neutral    7   F[A]=25%  F[T]=4%   Nali=776
                   -     0.256         -         -     0.163
     K235N        NA   Neutral        NA        NA   Neutral    7   F[K]=15%  F[N]=2%   Nali=891
                   -     0.227         -         -     0.156
     V346A        NA   Neutral        NA        NA   Neutral    6   F[V]=4%   F[A]=72%  Nali=998
                   -     0.042         -         -     0.201
     Y370H        NA   Neutral        NA        NA   Neutral    6   F[Y]=10%  F[H]=15%  Nali=975
                   -     0.180         -         -     0.181
     N392T        NA   Disease        NA        NA   Disease    2   F[N]=88%  F[T]=0%   Nali=998
                   -     0.816         -         -     0.591
     S441P        NA   Disease        NA        NA   Disease    0   F[S]=14%  F[P]=1%   Nali=954
                   -     0.705         -         -     0.512
     L480I        NA   Neutral        NA        NA   Neutral    7   F[L]=14%  F[I]=15%  Nali=972
                   -     0.054         -         -     0.152
     Q488K        NA   Neutral        NA        NA   Neutral    7   F[Q]=27%  F[K]=8%   Nali=990
                   -     0.400         -         -     0.172
     P492S        NA   Neutral        NA        NA   Neutral    7   F[P]=34%  F[S]=5%   Nali=990
                   -     0.337         -         -     0.171
     Q497E        NA   Neutral        NA        NA   Neutral    7   F[Q]=18%  F[E]=12%  Nali=988
                   -     0.255         -         -     0.151
     M507I        NA   Neutral        NA        NA   Neutral    7   F[M]=2%   F[I]=4%   Nali=969
                   -     0.240         -         -     0.140
     T511S        NA   Neutral        NA        NA   Neutral    7   F[T]=71%  F[S]=15%  Nali=942
                   -     0.335         -         -     0.159
     A515V        NA   Disease        NA        NA   Neutral    0   F[A]=73%  F[V]=3%   Nali=988
                   -     0.783         -         -     0.489
     G523V        NA   Disease        NA        NA   Disease    3   F[G]=43%  F[V]=1%   Nali=989
                   -     0.855         -         -     0.627
     V565L        NA   Neutral        NA        NA   Neutral    6   F[V]=34%  F[L]=19%  Nali=983
                   -     0.265         -         -     0.179
     A583V        NA   Disease        NA        NA   Neutral    0   F[A]=16%  F[V]=0%   Nali=909
                   -     0.509         -         -     0.487


  Mutation: WT+POS+NEW
    WT: Residue in wild-type protein
    POS: Residue position
    NEW: New residue after mutation
  Prediction:
    Neutral: Neutral variants
    Disease: Disease causing variants
  Outputs: Value reported under each prediction
    PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    PhD-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    SIFT: Positive Value (If >0.05 mutation is predicted Neutral)
    SNAP: Output normailzed between 0 and 1 (If >0.5 mutation is predicted Disease)
    Meta-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
  RI: Reliability Index between 0 an 10
  F[X]: Frequency of residue X in the sequence profile
  Nali: Number of aligned sequences in the mutated site