Meta-SNP: Meta-predictor of disease causing variants Cite: Capriotti et al. BMC Genomics 2013. Suppl 3:S2. WEB: http://snps.biofold.org/meta-snp Sequence File: SP.seq Mutation PANTHER PhD-SNP SIFT SNAP Meta-SNP RI Profile P2L Neutral Neutral Neutral Neutral Neutral 7 F[P]=89% F[L]=0% Nali=54 0.117 0.119 0.170 0.325 0.162 P2R Neutral Neutral Neutral Neutral Neutral 4 F[P]=89% F[R]=0% Nali=54 0.122 0.202 0.230 0.405 0.278 P2S Neutral Neutral Neutral Neutral Neutral 6 F[P]=89% F[S]=0% Nali=54 0.118 0.140 0.720 0.235 0.190 E3D Neutral Neutral Neutral Neutral Neutral 7 F[E]=93% F[D]=0% Nali=55 0.183 0.112 0.450 0.270 0.146 E4G Neutral Neutral Neutral Neutral Neutral 7 F[E]=59% F[G]=0% Nali=65 0.355 0.109 0.120 0.500 0.130 E4K Neutral Neutral Neutral Neutral Neutral 7 F[E]=59% F[K]=6% Nali=65 0.186 0.129 0.530 0.305 0.126 E4Q Neutral Neutral Neutral Neutral Neutral 8 F[E]=59% F[Q]=2% Nali=65 0.238 0.083 0.240 0.420 0.106 T5I Neutral Neutral Neutral Neutral Neutral 8 F[T]=38% F[I]=4% Nali=68 0.135 0.058 0.470 0.385 0.089 T5S Neutral Neutral Neutral Neutral Neutral 8 F[T]=38% F[S]=4% Nali=68 0.143 0.037 0.240 0.390 0.090 Q6E Neutral Neutral Neutral Neutral Neutral 8 F[Q]=35% F[E]=8% Nali=71 0.136 0.061 1.000 0.190 0.084 Q6R Neutral Neutral Neutral Neutral Neutral 8 F[Q]=35% F[R]=3% Nali=71 0.176 0.109 0.450 0.440 0.122 T7A Neutral Neutral Neutral Neutral Neutral 8 F[T]=51% F[A]=5% Nali=74 0.159 0.050 0.730 0.400 0.089 T7I Neutral Neutral Neutral Neutral Neutral 7 F[T]=51% F[I]=0% Nali=74 0.366 0.116 0.190 0.300 0.159 T7N Neutral Neutral Neutral Neutral Neutral 8 F[T]=51% F[N]=4% Nali=74 0.195 0.106 0.490 0.230 0.125 Q8R Neutral Neutral Neutral Disease Neutral 5 F[Q]=40% F[R]=0% Nali=72 0.315 0.190 0.220 0.530 0.261 D9E Neutral Neutral Neutral Neutral Neutral 8 F[D]=51% F[E]=14% Nali=68 0.149 0.083 1.000 0.205 0.092 D9H Neutral Neutral Neutral Disease Neutral 4 F[D]=51% F[H]=0% Nali=68 0.334 0.226 0.090 0.550 0.291 D9N Neutral Neutral Neutral Neutral Neutral 8 F[D]=51% F[N]=10% Nali=68 0.215 0.105 0.350 0.450 0.121 Q10H Neutral Neutral Neutral Neutral Neutral 7 F[Q]=43% F[H]=3% Nali=68 0.251 0.154 0.120 0.480 0.158 Q10P Neutral Neutral Neutral Neutral Neutral 2 F[Q]=43% F[P]=1% Nali=68 0.419 0.434 0.290 0.310 0.387 Q10R Neutral Neutral Neutral Neutral Neutral 4 F[Q]=43% F[R]=0% Nali=68 0.144 0.230 0.510 0.475 0.284 P11A Neutral Neutral Neutral Neutral Neutral 7 F[P]=65% F[A]=8% Nali=74 0.186 0.133 0.650 0.410 0.144 P11L Neutral Neutral Neutral Neutral Neutral 4 F[P]=65% F[L]=3% Nali=74 0.186 0.234 0.280 0.425 0.288 P11Q Neutral Neutral Neutral Neutral Neutral 4 F[P]=65% F[Q]=4% Nali=74 0.147 0.286 0.560 0.300 0.292 P11S Neutral Neutral Neutral Neutral Neutral 4 F[P]=65% F[S]=4% Nali=74 0.152 0.256 0.750 0.190 0.278 M12I Neutral Neutral Neutral Disease Neutral 4 F[M]=66% F[I]=0% Nali=104 0.143 0.354 0.190 0.505 0.315 M12T Neutral Neutral Neutral Neutral Neutral 3 F[M]=66% F[T]=4% Nali=104 0.252 0.461 0.570 0.375 0.338 M12V Neutral Neutral Neutral Neutral Neutral 4 F[M]=66% F[V]=5% Nali=104 0.166 0.272 0.300 0.365 0.289 E13D Neutral Neutral Neutral Neutral Neutral 6 F[E]=46% F[D]=5% Nali=128 0.350 0.182 0.500 0.195 0.195 E14G NA Neutral Disease Disease Neutral 4 F[E]=55% F[G]=2% Nali=174 - 0.328 0.050 0.565 0.281 E15D Neutral Neutral Neutral Neutral Neutral 6 F[E]=36% F[D]=6% Nali=235 0.372 0.165 0.440 0.170 0.209 E15G Neutral Neutral Neutral Neutral Neutral 4 F[E]=36% F[G]=7% Nali=235 0.246 0.194 0.290 0.495 0.290 E15K Neutral Neutral Neutral Neutral Neutral 1 F[E]=36% F[K]=4% Nali=235 0.453 0.332 0.550 0.420 0.437 E16V Neutral Neutral Neutral Neutral Neutral 1 F[E]=35% F[V]=0% Nali=270 0.393 0.330 0.200 0.415 0.443 V17F Disease Disease Disease Neutral Disease 0 F[V]=31% F[F]=1% Nali=341 0.557 0.558 0.020 0.475 0.522 V17I Neutral Neutral Neutral Neutral Neutral 4 F[V]=31% F[I]=5% Nali=341 0.345 0.171 0.120 0.345 0.300 V17L Neutral Neutral Neutral Neutral Neutral 0 F[V]=31% F[L]=1% Nali=341 0.359 0.312 0.130 0.310 0.476 T19I Disease Disease Disease Disease Disease 1 F[T]=68% F[I]=1% Nali=550 0.786 0.617 0.030 0.515 0.567 T19M Disease Neutral Disease Neutral Disease 3 F[T]=68% F[M]=1% Nali=550 0.818 0.462 0.010 0.440 0.644 F20C Disease Disease Disease Neutral Disease 4 F[F]=42% F[C]=1% Nali=566 0.911 0.716 0.040 0.460 0.693 F20L Disease Neutral Neutral Neutral Disease 2 F[F]=42% F[L]=17% Nali=566 0.549 0.335 0.580 0.235 0.603 F20S Disease Disease Neutral Disease Disease 2 F[F]=42% F[S]=0% Nali=566 0.785 0.706 0.060 0.510 0.616 F20Y Neutral Neutral Neutral Neutral Neutral 1 F[F]=42% F[Y]=9% Nali=566 0.456 0.429 0.570 0.220 0.474 A24S Disease Disease Neutral Neutral Disease 1 F[A]=70% F[S]=6% Nali=670 0.681 0.713 0.080 0.205 0.526 A24T Disease Neutral Neutral Neutral Disease 2 F[A]=70% F[T]=21% Nali=670 0.592 0.431 0.360 0.175 0.577 E25V Disease Disease Disease Disease Disease 7 F[E]=91% F[V]=0% Nali=678 0.949 0.887 0.000 0.660 0.846 A27G Disease Disease Neutral Neutral Neutral 0 F[A]=22% F[G]=5% Nali=697 0.528 0.540 0.230 0.235 0.485 A27S Neutral Neutral Neutral Neutral Neutral 1 F[A]=22% F[S]=13% Nali=697 0.217 0.370 0.910 0.080 0.457 A27T Neutral Disease Neutral Neutral Neutral 1 F[A]=22% F[T]=2% Nali=697 0.321 0.509 0.250 0.255 0.465 A27V Disease Disease Neutral Neutral Disease 0 F[A]=22% F[V]=0% Nali=697 0.557 0.631 0.090 0.275 0.501 L32F Disease Disease Disease Disease Disease 5 F[L]=77% F[F]=0% Nali=753 0.827 0.833 0.000 0.610 0.730 I34V Neutral Neutral Neutral Neutral Neutral 2 F[I]=71% F[V]=15% Nali=756 0.403 0.282 0.240 0.255 0.420 N35D Disease Disease Neutral Neutral Disease 4 F[N]=48% F[D]=0% Nali=757 0.721 0.818 0.060 0.335 0.712 N35S Disease Disease Disease Disease Disease 4 F[N]=48% F[S]=0% Nali=757 0.682 0.790 0.010 0.555 0.713 T36I Disease Disease Disease Disease Disease 5 F[T]=28% F[I]=0% Nali=766 0.528 0.842 0.000 0.565 0.771 T36S Neutral Neutral Neutral Neutral Neutral 4 F[T]=28% F[S]=62% Nali=766 0.326 0.086 1.000 0.150 0.301 S39L Disease Disease Disease Disease Disease 5 F[S]=76% F[L]=1% Nali=793 0.842 0.893 0.010 0.575 0.743 E42G Disease Disease Disease Disease Disease 5 F[E]=80% F[G]=0% Nali=795 0.857 0.743 0.000 0.680 0.755 E42Q Disease Disease Disease Disease Disease 3 F[E]=80% F[Q]=0% Nali=795 0.681 0.688 0.000 0.650 0.668 L48P Disease Disease Disease Disease Disease 7 F[L]=97% F[P]=0% Nali=802 0.984 0.823 0.000 0.705 0.852 I49V Neutral Neutral Neutral Neutral Neutral 4 F[I]=77% F[V]=21% Nali=801 0.416 0.177 0.250 0.315 0.281 S50A Disease Disease Disease Disease Disease 2 F[S]=99% F[A]=1% Nali=803 0.829 0.588 0.010 0.530 0.579 S50C Disease Disease Disease Disease Disease 6 F[S]=99% F[C]=0% Nali=803 0.966 0.767 0.000 0.580 0.819 S50F Disease Disease Disease Disease Disease 7 F[S]=99% F[F]=0% Nali=803 0.972 0.867 0.000 0.620 0.840 S50P Disease Disease Disease Disease Disease 6 F[S]=99% F[P]=0% Nali=803 0.941 0.846 0.000 0.655 0.824 S50Y Disease Disease Disease Disease Disease 7 F[S]=99% F[Y]=0% Nali=803 0.971 0.859 0.000 0.615 0.834 S52N Disease Disease Disease Disease Disease 5 F[S]=18% F[N]=0% Nali=803 0.800 0.769 0.000 0.615 0.766 S52R Disease Disease Disease Disease Disease 7 F[S]=18% F[R]=0% Nali=803 0.871 0.874 0.000 0.705 0.830 S53A Disease Neutral Neutral Neutral Disease 1 F[S]=83% F[A]=10% Nali=803 0.626 0.414 0.160 0.410 0.551 D57N Disease Disease Disease Disease Disease 0 F[D]=84% F[N]=1% Nali=808 0.746 0.693 0.010 0.505 0.523 K58R Disease Disease Disease Disease Disease 2 F[K]=98% F[R]=2% Nali=808 0.795 0.534 0.010 0.570 0.619 I59L Neutral Neutral Neutral Neutral Neutral 4 F[I]=41% F[L]=46% Nali=809 0.270 0.088 1.000 0.165 0.293 I59M Disease Neutral Disease Neutral Disease 3 F[I]=41% F[M]=1% Nali=809 0.712 0.328 0.010 0.430 0.647 I59T Disease Neutral Disease Disease Disease 3 F[I]=41% F[T]=0% Nali=809 0.664 0.433 0.010 0.590 0.670 I59V Neutral Neutral Neutral Neutral Neutral 4 F[I]=41% F[V]=3% Nali=809 0.465 0.171 0.130 0.285 0.303 E62Q Neutral Neutral Neutral Neutral Neutral 4 F[E]=39% F[Q]=10% Nali=808 0.350 0.150 0.530 0.195 0.279 S63G Disease Neutral Neutral Disease Disease 3 F[S]=49% F[G]=3% Nali=807 0.635 0.389 0.080 0.570 0.643 S63R Disease Disease Disease Disease Disease 5 F[S]=49% F[R]=1% Nali=807 0.600 0.638 0.000 0.735 0.748 T65I Disease Neutral Disease Disease Disease 3 F[T]=53% F[I]=3% Nali=807 0.616 0.437 0.020 0.560 0.631 D66N Neutral Neutral Neutral Neutral Neutral 1 F[D]=58% F[N]=17% Nali=808 0.408 0.270 0.390 0.335 0.442 D66Y Disease Disease Disease Disease Disease 6 F[D]=58% F[Y]=0% Nali=808 0.934 0.715 0.000 0.670 0.814 P67L Disease Neutral Disease Disease Disease 3 F[P]=42% F[L]=0% Nali=799 0.591 0.430 0.020 0.510 0.635 P67S Neutral Neutral Neutral Neutral Neutral 1 F[P]=42% F[S]=6% Nali=799 0.374 0.294 0.260 0.270 0.461 P67T Neutral Neutral Neutral Neutral Neutral 1 F[P]=42% F[T]=2% Nali=799 0.392 0.253 0.070 0.425 0.461 S68G Neutral Neutral Neutral Neutral Neutral 4 F[S]=36% F[G]=3% Nali=801 0.498 0.256 0.280 0.365 0.312 K69R Disease Neutral Neutral Neutral Neutral 2 F[K]=22% F[R]=2% Nali=798 0.534 0.230 0.470 0.310 0.393 D71A Neutral Neutral Neutral Neutral Neutral 1 F[D]=31% F[A]=6% Nali=806 0.265 0.251 0.140 0.395 0.437 D71E Neutral Neutral Neutral Neutral Neutral 4 F[D]=31% F[E]=30% Nali=806 0.198 0.098 0.460 0.175 0.307 S72A Neutral Neutral Neutral Neutral Neutral 4 F[S]=22% F[A]=8% Nali=806 0.191 0.102 0.780 0.130 0.311 S72C Disease Neutral Disease Neutral Disease 3 F[S]=22% F[C]=0% Nali=806 0.833 0.373 0.030 0.405 0.643 S72F Disease Neutral Neutral Neutral Disease 2 F[S]=22% F[F]=0% Nali=806 0.561 0.388 0.050 0.370 0.602 S72L Neutral Neutral Neutral Neutral Neutral 1 F[S]=22% F[L]=3% Nali=806 0.387 0.342 0.330 0.280 0.466 S72P Disease Disease Neutral Neutral Neutral 0 F[S]=22% F[P]=2% Nali=806 0.633 0.592 0.310 0.150 0.492 S72T Neutral Neutral Neutral Neutral Neutral 4 F[S]=22% F[T]=6% Nali=806 0.332 0.125 0.520 0.145 0.296 G73E Neutral Neutral Neutral Neutral Neutral 1 F[G]=25% F[E]=11% Nali=801 0.335 0.388 1.000 0.250 0.470 E75D Neutral Neutral Neutral Neutral Neutral 4 F[E]=43% F[D]=28% Nali=809 0.302 0.094 0.610 0.200 0.308 H77R Neutral Neutral Neutral Neutral Neutral 5 F[H]=9% F[R]=15% Nali=802 0.236 0.144 1.000 0.230 0.244 H77Y Neutral Neutral Neutral Neutral Neutral 3 F[H]=9% F[Y]=9% Nali=802 0.239 0.189 0.490 0.295 0.348 I78V Neutral Neutral Neutral Neutral Neutral 4 F[I]=84% F[V]=14% Nali=811 0.497 0.294 0.060 0.365 0.322 N79D Neutral Neutral Neutral Neutral Neutral 5 F[N]=5% F[D]=10% Nali=810 0.273 0.143 0.850 0.150 0.254 N79K Neutral Neutral Neutral Neutral Neutral 4 F[N]=5% F[K]=21% Nali=810 0.435 0.116 1.000 0.185 0.281 L80F Disease Disease Disease Neutral Disease 0 F[L]=20% F[F]=0% Nali=805 0.756 0.570 0.030 0.395 0.515 I81T Neutral Neutral Neutral Neutral Neutral 1 F[I]=27% F[T]=10% Nali=799 0.211 0.316 0.620 0.240 0.446 P82L Neutral Neutral Neutral Neutral Neutral 1 F[P]=40% F[L]=6% Nali=803 0.270 0.483 0.640 0.405 0.459 P82S Disease Neutral Neutral Neutral Neutral 1 F[P]=40% F[S]=1% Nali=803 0.526 0.455 0.390 0.405 0.441 N83D Neutral Neutral Neutral Neutral Neutral 5 F[N]=27% F[D]=69% Nali=809 0.385 0.072 1.000 0.330 0.229 N83S Disease Disease Disease Disease Disease 3 F[N]=27% F[S]=1% Nali=809 0.645 0.565 0.000 0.610 0.640 K84R Disease Disease Neutral Neutral Neutral 0 F[K]=67% F[R]=3% Nali=808 0.599 0.552 0.090 0.290 0.493 Q85E Neutral Neutral Neutral Neutral Neutral 5 F[Q]=7% F[E]=39% Nali=810 0.374 0.083 1.000 0.165 0.237 D86E Neutral Neutral Neutral Neutral Neutral 1 F[D]=11% F[E]=11% Nali=812 0.223 0.284 1.000 0.305 0.430 D86G Neutral Neutral Neutral Neutral Neutral 1 F[D]=11% F[G]=2% Nali=812 0.393 0.407 0.360 0.490 0.462 D86N Neutral Neutral Neutral Neutral Neutral 5 F[D]=11% F[N]=23% Nali=812 0.275 0.128 0.660 0.340 0.248 R87L Disease Disease Disease Disease Disease 4 F[R]=33% F[L]=0% Nali=811 0.606 0.756 0.050 0.595 0.713 R87Q Neutral Disease Neutral Disease Disease 1 F[R]=33% F[Q]=1% Nali=811 0.433 0.525 0.110 0.530 0.565 R87W Disease Disease Disease Disease Disease 6 F[R]=33% F[W]=0% Nali=811 0.910 0.761 0.010 0.625 0.799 T88A Disease Disease Disease Disease Disease 2 F[T]=75% F[A]=1% Nali=812 0.593 0.643 0.020 0.575 0.597 T88I Neutral Disease Neutral Neutral Disease 0 F[T]=75% F[I]=6% Nali=812 0.406 0.720 0.080 0.410 0.523 T88N Disease Disease Disease Disease Disease 5 F[T]=75% F[N]=0% Nali=812 0.836 0.826 0.020 0.615 0.747 T88S Disease Disease Disease Disease Disease 1 F[T]=75% F[S]=3% Nali=812 0.700 0.680 0.030 0.565 0.545 L89F Disease Disease Disease Disease Disease 2 F[L]=74% F[F]=3% Nali=812 0.738 0.735 0.010 0.555 0.591 L89V Disease Disease Neutral Neutral Neutral 0 F[L]=74% F[V]=6% Nali=812 0.647 0.650 0.110 0.375 0.495 T90A Disease Disease Disease Disease Disease 2 F[T]=68% F[A]=1% Nali=810 0.570 0.601 0.020 0.615 0.610 T90I Neutral Disease Disease Disease Disease 1 F[T]=68% F[I]=4% Nali=810 0.391 0.728 0.040 0.535 0.533 T90S Neutral Disease Neutral Neutral Neutral 1 F[T]=68% F[S]=9% Nali=810 0.386 0.525 0.170 0.370 0.473 I91V Neutral Neutral Neutral Neutral Neutral 2 F[I]=71% F[V]=15% Nali=812 0.390 0.317 0.280 0.280 0.423 V92M Neutral Neutral Neutral Neutral Neutral 1 F[V]=6% F[M]=2% Nali=812 0.375 0.260 0.110 0.215 0.457 T94A Disease Disease Disease Disease Disease 4 F[T]=40% F[A]=0% Nali=815 0.598 0.581 0.010 0.675 0.717 T94I Disease Disease Disease Disease Disease 6 F[T]=40% F[I]=0% Nali=815 0.826 0.748 0.000 0.710 0.785 T94S Neutral Neutral Neutral Neutral Neutral 1 F[T]=40% F[S]=15% Nali=815 0.353 0.392 0.410 0.350 0.447 G95A Disease Disease Disease Disease Disease 8 F[G]=100% F[A]=0% Nali=815 0.965 0.713 0.000 0.785 0.880 G95S Disease Disease Disease Disease Disease 8 F[G]=100% F[S]=0% Nali=815 0.971 0.841 0.000 0.805 0.876 I96V Neutral Neutral Neutral Neutral Neutral 1 F[I]=86% F[V]=9% Nali=815 0.380 0.488 0.170 0.400 0.439 T99S Disease Disease Neutral Neutral Neutral 1 F[T]=69% F[S]=17% Nali=820 0.578 0.502 0.380 0.230 0.458 K100R Neutral Neutral Neutral Neutral Neutral 1 F[K]=50% F[R]=28% Nali=819 0.427 0.292 0.590 0.120 0.451 D102G Disease Disease Disease Disease Disease 5 F[D]=47% F[G]=1% Nali=820 0.806 0.880 0.020 0.570 0.742 L103V Neutral Neutral Neutral Neutral Neutral 1 F[L]=64% F[V]=24% Nali=820 0.452 0.307 0.360 0.195 0.454 I104N Disease Disease Disease Disease Disease 4 F[I]=45% F[N]=1% Nali=817 0.707 0.892 0.030 0.510 0.679 I104V Neutral Neutral Neutral Neutral Neutral 4 F[I]=45% F[V]=32% Nali=817 0.208 0.170 0.620 0.185 0.282 N105S Neutral Disease Neutral Neutral Neutral 1 F[N]=40% F[S]=5% Nali=819 0.318 0.614 0.310 0.235 0.463 L107V Disease Disease Disease Disease Disease 3 F[L]=83% F[V]=0% Nali=821 0.803 0.722 0.010 0.535 0.640 G108C Disease Disease Disease Disease Disease 7 F[G]=94% F[C]=0% Nali=821 0.954 0.898 0.000 0.680 0.834 G108V Disease Disease Disease Disease Disease 6 F[G]=94% F[V]=0% Nali=821 0.922 0.866 0.000 0.665 0.820 T109I Disease Disease Disease Disease Disease 5 F[T]=90% F[I]=1% Nali=822 0.906 0.871 0.000 0.580 0.755 I110V Disease Disease Neutral Neutral Neutral 0 F[I]=93% F[V]=5% Nali=822 0.578 0.542 0.060 0.405 0.478 A111T Disease Disease Disease Disease Disease 6 F[A]=99% F[T]=0% Nali=822 0.874 0.895 0.000 0.670 0.797 T115A Neutral Disease Disease Disease Neutral 1 F[T]=83% F[A]=6% Nali=821 0.479 0.542 0.020 0.515 0.452 T115I Disease Disease Disease Disease Disease 6 F[T]=83% F[I]=0% Nali=821 0.891 0.883 0.000 0.620 0.799 T115P Disease Disease Disease Disease Disease 7 F[T]=83% F[P]=0% Nali=821 0.884 0.896 0.000 0.745 0.849 T115S Neutral Disease Neutral Neutral Neutral 1 F[T]=83% F[S]=10% Nali=821 0.332 0.597 0.060 0.320 0.437 M119L Neutral Neutral Neutral Neutral Neutral 1 F[M]=41% F[L]=31% Nali=826 0.257 0.361 1.000 0.225 0.455 A121G Disease Disease Neutral Neutral Disease 1 F[A]=46% F[G]=0% Nali=822 0.716 0.748 0.110 0.295 0.568 L122F Disease Disease Disease Disease Disease 3 F[L]=67% F[F]=1% Nali=821 0.624 0.792 0.020 0.590 0.662 L122V Neutral Disease Neutral Neutral Neutral 0 F[L]=67% F[V]=3% Nali=821 0.477 0.678 0.090 0.290 0.492 A124P Disease Disease Neutral Neutral Disease 5 F[A]=39% F[P]=0% Nali=822 0.672 0.912 0.050 0.285 0.742 A124V Disease Disease Neutral Neutral Disease 2 F[A]=39% F[V]=1% Nali=822 0.619 0.759 0.080 0.300 0.602 A126G Neutral Disease Neutral Neutral Neutral 0 F[A]=42% F[G]=9% Nali=820 0.464 0.592 0.340 0.345 0.479 A126S Neutral Disease Neutral Neutral Neutral 1 F[A]=42% F[S]=5% Nali=820 0.365 0.651 0.550 0.195 0.432 A126V Disease Disease Neutral Neutral Disease 3 F[A]=42% F[V]=1% Nali=820 0.741 0.792 0.150 0.405 0.660 D127H Disease Disease Disease Disease Disease 6 F[D]=78% F[H]=0% Nali=829 0.821 0.886 0.010 0.705 0.788 I128M Neutral Neutral Neutral Neutral Neutral 0 F[I]=30% F[M]=3% Nali=821 0.423 0.399 0.120 0.255 0.480 I128V Neutral Neutral Neutral Neutral Neutral 2 F[I]=30% F[V]=11% Nali=821 0.235 0.229 0.370 0.240 0.422 S129C Disease Disease Disease Disease Disease 6 F[S]=41% F[C]=0% Nali=812 0.926 0.837 0.000 0.565 0.818 M130I Neutral Disease Neutral Disease Disease 1 F[M]=35% F[I]=11% Nali=819 0.205 0.750 0.070 0.505 0.536 M130L Neutral Neutral Neutral Neutral Neutral 1 F[M]=35% F[L]=52% Nali=819 0.260 0.343 1.000 0.385 0.439 M130V Neutral Disease Disease Disease Disease 6 F[M]=35% F[V]=1% Nali=819 0.443 0.859 0.000 0.735 0.789 G132D Disease Disease Disease Disease Disease 7 F[G]=100% F[D]=0% Nali=833 0.958 0.925 0.000 0.855 0.872 G132V Disease Disease Disease Disease Disease 8 F[G]=100% F[V]=0% Nali=833 0.958 0.937 0.000 0.800 0.888 F134L Disease Disease Disease Disease Disease 6 F[F]=100% F[L]=0% Nali=839 0.933 0.854 0.030 0.710 0.810 S140C Disease Disease Disease Disease Disease 7 F[S]=94% F[C]=0% Nali=840 0.918 0.875 0.000 0.710 0.827 A141S Disease Disease Neutral Neutral Neutral 1 F[A]=72% F[S]=13% Nali=839 0.568 0.621 0.400 0.260 0.457 A141T Disease Disease Neutral Neutral Disease 1 F[A]=72% F[T]=3% Nali=839 0.657 0.756 0.110 0.360 0.554 Y142N Disease Disease Disease Disease Disease 7 F[Y]=34% F[N]=0% Nali=839 0.916 0.908 0.000 0.680 0.832 L143F Disease Disease Disease Disease Disease 5 F[L]=49% F[F]=0% Nali=839 0.835 0.843 0.000 0.630 0.772 V144F Disease Disease Disease Disease Disease 7 F[V]=95% F[F]=0% Nali=839 0.963 0.941 0.000 0.705 0.836 A145V Disease Disease Disease Disease Disease 6 F[A]=89% F[V]=0% Nali=839 0.919 0.898 0.010 0.660 0.821 E146A Disease Disease Disease Disease Disease 2 F[E]=19% F[A]=0% Nali=842 0.551 0.534 0.000 0.525 0.601 E146D Neutral Neutral Neutral Neutral Neutral 5 F[E]=19% F[D]=68% Nali=842 0.381 0.066 1.000 0.120 0.270 E146G Neutral Disease Disease Disease Disease 4 F[E]=19% F[G]=0% Nali=842 0.474 0.686 0.000 0.590 0.713 K147N Disease Disease Neutral Neutral Disease 1 F[K]=52% F[N]=1% Nali=842 0.630 0.735 0.060 0.370 0.526 T149A Neutral Neutral Neutral Neutral Neutral 1 F[T]=42% F[A]=1% Nali=842 0.360 0.324 0.170 0.385 0.463 T149I Neutral Neutral Neutral Neutral Neutral 1 F[T]=42% F[I]=6% Nali=842 0.212 0.421 0.170 0.240 0.459 T149S Neutral Neutral Neutral Neutral Neutral 0 F[T]=42% F[S]=2% Nali=842 0.373 0.433 0.230 0.225 0.480 V150M Disease Disease Disease Disease Disease 5 F[V]=84% F[M]=0% Nali=841 0.909 0.771 0.000 0.590 0.761 I151M Disease Neutral Neutral Neutral Disease 1 F[I]=23% F[M]=0% Nali=842 0.607 0.287 0.190 0.415 0.555 I151V Neutral Neutral Neutral Neutral Neutral 4 F[I]=23% F[V]=12% Nali=842 0.256 0.121 0.790 0.205 0.296 T152A Disease Disease Disease Disease Disease 4 F[T]=51% F[A]=0% Nali=842 0.716 0.547 0.000 0.655 0.696 K153R Neutral Neutral Neutral Neutral Neutral 5 F[K]=61% F[R]=33% Nali=842 0.365 0.152 0.620 0.255 0.243 H154R Disease Neutral Neutral Neutral Disease 2 F[H]=33% F[R]=17% Nali=840 0.555 0.305 0.350 0.465 0.596 H154Y Disease Disease Neutral Neutral Disease 2 F[H]=33% F[Y]=2% Nali=840 0.802 0.598 1.000 0.320 0.585 N155K Neutral Neutral Neutral Neutral Neutral 1 F[N]=40% F[K]=4% Nali=836 0.311 0.353 0.170 0.360 0.452 D156G Neutral Neutral Neutral Neutral Neutral 1 F[D]=45% F[G]=21% Nali=841 0.397 0.323 0.130 0.470 0.468 D156H Disease Disease Neutral Neutral Disease 1 F[D]=45% F[H]=0% Nali=841 0.831 0.537 0.070 0.420 0.561 D156N Neutral Neutral Neutral Neutral Neutral 0 F[D]=45% F[N]=3% Nali=841 0.396 0.471 0.160 0.305 0.487 D156Y Disease Disease Neutral Disease Disease 5 F[D]=45% F[Y]=0% Nali=841 0.899 0.760 0.080 0.530 0.749 D157V Disease Disease Disease Disease Disease 5 F[D]=61% F[V]=0% Nali=842 0.822 0.762 0.030 0.620 0.731 E158D Neutral Neutral Neutral Neutral Neutral 1 F[E]=51% F[D]=10% Nali=840 0.436 0.255 0.300 0.270 0.459 E158G Disease Neutral Neutral Disease Disease 3 F[E]=51% F[G]=3% Nali=840 0.685 0.438 0.060 0.540 0.640 E158K Neutral Neutral Neutral Neutral Neutral 1 F[E]=51% F[K]=12% Nali=840 0.295 0.366 0.440 0.400 0.445 Q159P Disease Disease Neutral Disease Disease 3 F[Q]=42% F[P]=4% Nali=841 0.821 0.779 0.220 0.505 0.642 Q159R Disease Disease Neutral Disease Disease 2 F[Q]=42% F[R]=0% Nali=841 0.668 0.643 0.380 0.510 0.582 Y160N Disease Disease Disease Disease Disease 4 F[Y]=48% F[N]=0% Nali=840 0.761 0.694 0.030 0.605 0.707 A161T Neutral Neutral Neutral Neutral Neutral 4 F[A]=10% F[T]=5% Nali=840 0.416 0.165 0.390 0.305 0.324 A161V Neutral Neutral Neutral Neutral Neutral 4 F[A]=10% F[V]=17% Nali=840 0.241 0.090 0.520 0.190 0.285 E163V Disease Disease Neutral Neutral Disease 1 F[E]=64% F[V]=4% Nali=840 0.762 0.618 0.060 0.480 0.538 S164C Disease Disease Disease Disease Neutral 0 F[S]=92% F[C]=5% Nali=839 0.684 0.609 0.010 0.620 0.477 S164F Disease Disease Disease Disease Disease 6 F[S]=92% F[F]=0% Nali=839 0.920 0.795 0.000 0.715 0.818 S165A Neutral Neutral Neutral Neutral Neutral 4 F[S]=29% F[A]=12% Nali=840 0.316 0.106 0.700 0.235 0.279 S165L Disease Neutral Neutral Neutral Disease 2 F[S]=29% F[L]=0% Nali=840 0.570 0.393 0.070 0.450 0.612 G167V Disease Neutral Neutral Neutral Disease 3 F[G]=41% F[V]=2% Nali=821 0.666 0.420 0.120 0.450 0.632 S169L Disease Disease Disease Disease Disease 4 F[S]=42% F[L]=0% Nali=835 0.655 0.522 0.040 0.555 0.676 T171A Neutral Neutral Neutral Neutral Neutral 1 F[T]=60% F[A]=3% Nali=835 0.459 0.332 0.090 0.405 0.457 T171I Disease Disease Disease Disease Neutral 0 F[T]=60% F[I]=3% Nali=835 0.627 0.515 0.030 0.510 0.496 T171R Disease Disease Disease Disease Disease 2 F[T]=60% F[R]=1% Nali=835 0.624 0.597 0.030 0.615 0.614 T171S Neutral Neutral Neutral Neutral Neutral 1 F[T]=60% F[S]=11% Nali=835 0.349 0.236 0.250 0.230 0.448 V172L Neutral Neutral Neutral Neutral Neutral 1 F[V]=42% F[L]=9% Nali=833 0.428 0.299 0.220 0.280 0.465 V172M Disease Neutral Disease Disease Disease 4 F[V]=42% F[M]=2% Nali=833 0.835 0.401 0.000 0.630 0.676 R173K Neutral Neutral Neutral Neutral Neutral 4 F[R]=20% F[K]=10% Nali=678 0.276 0.148 0.530 0.165 0.278 T174I Disease Neutral Neutral Neutral Neutral 2 F[T]=15% F[I]=3% Nali=685 0.607 0.189 0.050 0.285 0.422 T174R Neutral Neutral Neutral Neutral Neutral 1 F[T]=15% F[R]=6% Nali=685 0.262 0.241 0.300 0.215 0.436 D175N Disease Neutral Neutral Neutral Disease 2 F[D]=50% F[N]=2% Nali=775 0.699 0.481 0.250 0.350 0.591 T176A Neutral Neutral Neutral Neutral Neutral 3 F[T]=23% F[A]=4% Nali=791 0.228 0.185 0.240 0.380 0.370 E178K Neutral Disease Neutral Neutral Neutral 1 F[E]=55% F[K]=5% Nali=821 0.339 0.635 0.910 0.335 0.468 P179A Neutral Neutral Neutral Neutral Neutral 1 F[P]=30% F[A]=4% Nali=763 0.240 0.255 0.600 0.330 0.427 P179L Neutral Neutral Neutral Neutral Neutral 1 F[P]=30% F[L]=2% Nali=763 0.340 0.412 0.270 0.370 0.463 P179R Neutral Neutral Neutral Neutral Neutral 1 F[P]=30% F[R]=8% Nali=763 0.182 0.448 0.480 0.340 0.447 P179S Neutral Neutral Neutral Neutral Neutral 1 F[P]=30% F[S]=7% Nali=763 0.205 0.324 0.580 0.315 0.450 P179T Neutral Neutral Neutral Neutral Neutral 3 F[P]=30% F[T]=11% Nali=763 0.175 0.208 0.440 0.320 0.366 M180I Neutral Neutral Neutral Neutral Neutral 4 F[M]=6% F[I]=14% Nali=705 0.455 0.131 0.240 0.270 0.301 M180V Neutral Neutral Neutral Neutral Neutral 2 F[M]=6% F[V]=7% Nali=705 0.473 0.244 0.320 0.420 0.425 G181D Neutral Disease Neutral Neutral Disease 1 F[G]=41% F[D]=5% Nali=725 0.436 0.688 0.440 0.380 0.529 R182C Disease Disease Disease Disease Disease 6 F[R]=80% F[C]=0% Nali=807 0.907 0.871 0.020 0.675 0.806 R182G Disease Disease Disease Disease Disease 5 F[R]=80% F[G]=0% Nali=807 0.791 0.805 0.000 0.690 0.747 R182H Disease Disease Neutral Neutral Disease 3 F[R]=80% F[H]=5% Nali=807 0.820 0.730 0.090 0.445 0.630 V186I Neutral Neutral Neutral Neutral Neutral 5 F[V]=22% F[I]=71% Nali=834 0.314 0.040 1.000 0.175 0.247 I187M Disease Neutral Disease Disease Disease 3 F[I]=30% F[M]=1% Nali=832 0.646 0.442 0.020 0.605 0.657 I187S Neutral Disease Neutral Neutral Disease 1 F[I]=30% F[S]=4% Nali=832 0.403 0.686 0.250 0.400 0.531 I187T Neutral Neutral Neutral Neutral Neutral 3 F[I]=30% F[T]=34% Nali=832 0.225 0.190 1.000 0.245 0.345 L188V Disease Disease Disease Disease Disease 2 F[L]=90% F[V]=1% Nali=833 0.741 0.737 0.010 0.580 0.623 H189N Disease Disease Disease Disease Disease 5 F[H]=58% F[N]=0% Nali=833 0.766 0.828 0.010 0.680 0.736 H189Y Neutral Disease Neutral Neutral Neutral 0 F[H]=58% F[Y]=16% Nali=833 0.407 0.630 0.260 0.455 0.484 K191R Neutral Neutral Neutral Neutral Neutral 2 F[K]=72% F[R]=17% Nali=831 0.492 0.314 0.160 0.365 0.381 E192D Neutral Neutral Neutral Neutral Neutral 1 F[E]=65% F[D]=19% Nali=831 0.387 0.275 0.340 0.225 0.449 E192K Disease Disease Disease Disease Disease 1 F[E]=65% F[K]=3% Nali=831 0.534 0.726 0.040 0.585 0.560 D193A Disease Disease Disease Disease Disease 1 F[D]=63% F[A]=2% Nali=833 0.674 0.655 0.040 0.635 0.556 D193E Neutral Neutral Neutral Neutral Neutral 1 F[D]=63% F[E]=21% Nali=833 0.322 0.295 0.440 0.310 0.450 Q194H Disease Neutral Neutral Neutral Disease 3 F[Q]=32% F[H]=1% Nali=826 0.660 0.447 0.110 0.310 0.640 T195A Neutral Neutral Neutral Neutral Neutral 5 F[T]=19% F[A]=6% Nali=825 0.255 0.152 0.510 0.255 0.275 T195I Disease Neutral Neutral Neutral Disease 1 F[T]=19% F[I]=1% Nali=825 0.566 0.277 0.130 0.295 0.534 L198F Disease Disease Disease Neutral Disease 0 F[L]=69% F[F]=0% Nali=833 0.587 0.653 0.010 0.490 0.509 E200A Disease Neutral Neutral Neutral Neutral 3 F[E]=54% F[A]=5% Nali=834 0.520 0.362 0.230 0.330 0.370 R201L Disease Disease Neutral Neutral Disease 0 F[R]=20% F[L]=1% Nali=834 0.506 0.580 0.670 0.250 0.510 R201Q Neutral Neutral Neutral Neutral Neutral 1 F[R]=20% F[Q]=0% Nali=834 0.337 0.370 0.350 0.290 0.475 R202K Neutral Neutral Neutral Neutral Neutral 2 F[R]=55% F[K]=29% Nali=835 0.243 0.223 0.810 0.155 0.409 R202T Neutral Disease Neutral Neutral Neutral 0 F[R]=55% F[T]=9% Nali=835 0.347 0.648 0.210 0.350 0.494 I203T Disease Disease Disease Neutral Disease 2 F[I]=44% F[T]=0% Nali=835 0.859 0.655 0.000 0.495 0.590 I206L Neutral Neutral Neutral Neutral Neutral 1 F[I]=45% F[L]=35% Nali=835 0.323 0.226 1.000 0.105 0.446 I206S Disease Disease Disease Disease Disease 5 F[I]=45% F[S]=0% Nali=835 0.867 0.858 0.000 0.525 0.772 I206T Disease Disease Disease Neutral Disease 1 F[I]=45% F[T]=2% Nali=835 0.659 0.695 0.040 0.405 0.566 I206V Neutral Neutral Neutral Neutral Neutral 1 F[I]=45% F[V]=18% Nali=835 0.216 0.252 0.260 0.200 0.436 V207A Disease Disease Disease Neutral Disease 0 F[V]=54% F[A]=1% Nali=835 0.676 0.636 0.040 0.410 0.503 K208E Disease Disease Disease Neutral Disease 1 F[K]=61% F[E]=5% Nali=834 0.519 0.707 0.050 0.445 0.539 K209R Neutral Disease Neutral Neutral Neutral 1 F[K]=80% F[R]=8% Nali=833 0.486 0.549 0.140 0.300 0.452 H210Q Disease Disease Disease Disease Disease 5 F[H]=36% F[Q]=2% Nali=833 0.908 0.750 0.010 0.580 0.754 H210Y Neutral Neutral Neutral Neutral Neutral 2 F[H]=36% F[Y]=59% Nali=833 0.373 0.277 1.000 0.365 0.416 S211A Disease Disease Disease Disease Disease 2 F[S]=93% F[A]=1% Nali=832 0.764 0.641 0.010 0.590 0.597 S211F Disease Disease Disease Disease Disease 7 F[S]=93% F[F]=0% Nali=832 0.974 0.896 0.000 0.690 0.855 I214V Neutral Neutral Neutral Neutral Neutral 2 F[I]=77% F[V]=16% Nali=831 0.318 0.342 0.270 0.245 0.407 G215V Disease Disease Neutral Neutral Disease 0 F[G]=28% F[V]=1% Nali=805 0.594 0.651 0.120 0.310 0.520 P217H Disease Disease Disease Disease Disease 7 F[P]=94% F[H]=0% Nali=832 0.985 0.875 0.000 0.730 0.841 P217L Disease Disease Disease Disease Disease 7 F[P]=94% F[L]=0% Nali=832 0.981 0.883 0.010 0.605 0.829 I218F Disease Disease Disease Disease Disease 6 F[I]=82% F[F]=0% Nali=829 0.910 0.860 0.000 0.580 0.776 I218L Disease Disease Disease Neutral Disease 0 F[I]=82% F[L]=1% Nali=829 0.505 0.734 0.010 0.375 0.514 I218T Disease Disease Disease Disease Disease 5 F[I]=82% F[T]=1% Nali=829 0.903 0.835 0.000 0.570 0.751 I218V Neutral Neutral Neutral Neutral Neutral 2 F[I]=82% F[V]=16% Nali=829 0.441 0.330 0.150 0.190 0.411 T219S Neutral Neutral Neutral Neutral Neutral 4 F[T]=9% F[S]=7% Nali=769 0.269 0.150 0.740 0.060 0.300 F221L Neutral Neutral Neutral Neutral Neutral 1 F[F]=13% F[L]=12% Nali=616 0.408 0.269 0.650 0.150 0.445 E223K Neutral Disease Neutral Neutral Neutral 0 F[E]=57% F[K]=5% Nali=553 0.419 0.654 0.170 0.310 0.485 E223V Disease Disease Neutral Neutral Disease 2 F[E]=57% F[V]=2% Nali=553 0.667 0.718 0.090 0.445 0.615 K224R Neutral Neutral Neutral Neutral Neutral 1 F[K]=73% F[R]=7% Nali=541 0.381 0.451 0.170 0.220 0.453 R226C Disease Disease Disease Neutral Disease 0 F[R]=36% F[C]=0% Nali=484 0.552 0.568 0.040 0.495 0.519 R226H Neutral Neutral Neutral Neutral Neutral 0 F[R]=36% F[H]=2% Nali=484 0.439 0.321 0.110 0.185 0.483 D227N Neutral Neutral Neutral Neutral Neutral 1 F[D]=26% F[N]=2% Nali=473 0.389 0.275 0.120 0.290 0.467 K228E Neutral Neutral Neutral Neutral Neutral 1 F[K]=61% F[E]=12% Nali=480 0.148 0.375 0.680 0.195 0.437 E229V Disease Disease Neutral Disease Disease 0 F[E]=71% F[V]=1% Nali=463 0.697 0.621 0.060 0.510 0.515 V230G Neutral Disease Neutral Neutral Neutral 0 F[V]=57% F[G]=5% Nali=450 0.410 0.544 0.370 0.400 0.479 V230I Neutral Neutral Neutral Neutral Neutral 4 F[V]=57% F[I]=15% Nali=450 0.185 0.092 0.360 0.205 0.289 S231R Neutral Neutral Neutral Neutral Neutral 3 F[S]=36% F[R]=1% Nali=456 0.374 0.166 0.220 0.410 0.334 D232A Neutral Neutral Neutral Neutral Neutral 2 F[D]=53% F[A]=4% Nali=420 0.140 0.233 0.340 0.410 0.424 D232E Neutral Neutral Neutral Neutral Neutral 4 F[D]=53% F[E]=14% Nali=420 0.193 0.092 0.660 0.200 0.292 D232G Neutral Neutral Neutral Neutral Neutral 1 F[D]=53% F[G]=2% Nali=420 0.448 0.360 0.180 0.425 0.471 D232Y Disease Neutral Disease Disease Disease 3 F[D]=53% F[Y]=1% Nali=420 0.619 0.401 0.010 0.545 0.635 D233E Neutral Neutral Neutral Neutral Neutral 5 F[D]=52% F[E]=20% Nali=423 0.212 0.071 0.730 0.190 0.263 D233N Neutral Neutral Disease Disease Neutral 0 F[D]=52% F[N]=1% Nali=423 0.363 0.255 0.020 0.530 0.486 A235G Neutral Neutral Neutral Neutral Neutral 4 F[A]=36% F[G]=5% Nali=446 0.345 0.124 0.290 0.345 0.321 A235T Neutral Neutral Neutral Neutral Neutral 4 F[A]=36% F[T]=6% Nali=446 0.281 0.093 0.440 0.210 0.319 A235V Neutral Neutral Neutral Neutral Neutral 3 F[A]=36% F[V]=4% Nali=446 0.346 0.095 0.230 0.375 0.337 E236Q Neutral Neutral Neutral Neutral Neutral 4 F[E]=50% F[Q]=2% Nali=438 0.388 0.139 0.080 0.290 0.308 E237G Disease Neutral Disease Disease Neutral 0 F[E]=46% F[G]=1% Nali=447 0.597 0.216 0.030 0.570 0.483 E237K Disease Neutral Neutral Neutral Neutral 3 F[E]=46% F[K]=9% Nali=447 0.607 0.163 0.350 0.295 0.341 E237Q Disease Neutral Disease Neutral Neutral 5 F[E]=46% F[Q]=2% Nali=447 0.519 0.129 0.050 0.480 0.248 K238N NA Neutral Disease Neutral Neutral 5 F[K]=26% F[N]=0% Nali=442 - 0.138 0.040 0.380 0.259 E239K NA Neutral Neutral Neutral Neutral 6 F[E]=41% F[K]=20% Nali=437 - 0.085 1.000 0.230 0.181 D240E Neutral Neutral Neutral Neutral Neutral 6 F[D]=21% F[E]=32% Nali=425 0.229 0.019 1.000 0.145 0.219 D240G Neutral Neutral Neutral Neutral Neutral 3 F[D]=21% F[G]=4% Nali=425 0.189 0.118 0.340 0.405 0.343 D240N Neutral Neutral Neutral Neutral Neutral 4 F[D]=21% F[N]=3% Nali=425 0.196 0.078 0.280 0.225 0.301 K241E Neutral Neutral Neutral Neutral Neutral 6 F[K]=32% F[E]=29% Nali=448 0.188 0.058 1.000 0.210 0.221 K241N Neutral Neutral Neutral Neutral Neutral 3 F[K]=32% F[N]=1% Nali=448 0.320 0.170 0.050 0.415 0.336 K241Q Neutral Neutral Neutral Neutral Neutral 3 F[K]=32% F[Q]=2% Nali=448 0.288 0.116 0.070 0.380 0.347 K241R Neutral Neutral Neutral Neutral Neutral 5 F[K]=32% F[R]=2% Nali=448 0.326 0.065 0.050 0.360 0.275 E242K Neutral Neutral Neutral Neutral Neutral 4 F[E]=38% F[K]=12% Nali=453 0.115 0.115 0.910 0.215 0.279 E242Q Neutral Neutral Neutral Neutral Neutral 4 F[E]=38% F[Q]=2% Nali=453 0.164 0.104 0.590 0.180 0.311 E243D Neutral Neutral Neutral Neutral Neutral 5 F[E]=54% F[D]=12% Nali=464 0.131 0.116 0.570 0.205 0.272 E243K Neutral Neutral Neutral Neutral Neutral 5 F[E]=54% F[K]=12% Nali=464 0.169 0.169 0.810 0.285 0.249 E244A Neutral Neutral Neutral Neutral Neutral 4 F[E]=41% F[A]=6% Nali=467 0.307 0.093 0.220 0.455 0.310 E244K Neutral Neutral Neutral Neutral Neutral 4 F[E]=41% F[K]=11% Nali=467 0.306 0.122 0.420 0.290 0.289 K245E Neutral Neutral Neutral Neutral Neutral 6 F[K]=33% F[E]=29% Nali=459 0.131 0.056 1.000 0.190 0.220 K245R Neutral Neutral Neutral Neutral Neutral 4 F[K]=33% F[R]=0% Nali=459 0.275 0.061 0.180 0.330 0.286 E246D Neutral Neutral Neutral Neutral Neutral 5 F[E]=37% F[D]=17% Nali=453 0.360 0.053 0.520 0.180 0.263 E246G Neutral Neutral Neutral Neutral Neutral 3 F[E]=37% F[G]=4% Nali=453 0.398 0.124 0.250 0.475 0.338 E246K Neutral Neutral Neutral Neutral Neutral 5 F[E]=37% F[K]=17% Nali=453 0.228 0.078 0.690 0.260 0.271 K247E Neutral Neutral Neutral Neutral Neutral 5 F[K]=26% F[E]=27% Nali=461 0.181 0.043 1.000 0.185 0.233 K247R Neutral Neutral Neutral Neutral Neutral 5 F[K]=26% F[R]=2% Nali=461 0.321 0.041 0.390 0.160 0.268 E248G Neutral Neutral Neutral Neutral Neutral 5 F[E]=47% F[G]=3% Nali=450 0.497 0.158 0.270 0.425 0.246 E248K Neutral Neutral Neutral Neutral Neutral 4 F[E]=47% F[K]=14% Nali=450 0.319 0.107 0.510 0.310 0.278 E249K Neutral Neutral Neutral Neutral Neutral 5 F[E]=34% F[K]=16% Nali=451 0.348 0.084 0.700 0.250 0.269 E249Q Neutral Neutral Neutral Neutral Neutral 4 F[E]=34% F[Q]=2% Nali=451 0.391 0.087 0.430 0.210 0.310 K250E Neutral Neutral Neutral Neutral Neutral 5 F[K]=28% F[E]=27% Nali=459 0.062 0.061 1.000 0.140 0.231 K250R Neutral Neutral Neutral Neutral Neutral 4 F[K]=28% F[R]=1% Nali=459 0.117 0.060 0.370 0.245 0.286 S252L Neutral Neutral Neutral Neutral Neutral 5 F[S]=9% F[L]=2% Nali=442 0.171 0.047 0.150 0.300 0.264 S252W Disease Neutral Disease Disease Neutral 3 F[S]=9% F[W]=0% Nali=442 0.582 0.134 0.010 0.505 0.361 E253K Neutral Neutral Neutral Neutral Neutral 5 F[E]=38% F[K]=9% Nali=430 0.103 0.167 0.640 0.280 0.247 D254H Neutral Neutral Disease Disease Neutral 2 F[D]=45% F[H]=0% Nali=416 0.366 0.196 0.030 0.510 0.408 D254N Neutral Neutral Neutral Neutral Neutral 4 F[D]=45% F[N]=4% Nali=416 0.127 0.167 0.170 0.230 0.317 K255I Neutral Neutral Neutral Neutral Neutral 2 F[K]=42% F[I]=2% Nali=424 0.357 0.194 0.160 0.335 0.389 P256H Disease Neutral Neutral Neutral Disease 2 F[P]=60% F[H]=0% Nali=428 0.592 0.309 0.080 0.395 0.583 P256L Neutral Neutral Neutral Neutral Neutral 1 F[P]=60% F[L]=0% Nali=428 0.376 0.304 0.200 0.335 0.455 E259D Neutral Neutral Neutral Neutral Neutral 3 F[E]=70% F[D]=6% Nali=406 0.334 0.202 0.320 0.180 0.368 E259K Neutral Neutral Neutral Neutral Neutral 1 F[E]=70% F[K]=8% Nali=406 0.453 0.275 0.500 0.235 0.444 D260A Neutral Neutral Neutral Neutral Neutral 1 F[D]=47% F[A]=3% Nali=381 0.279 0.253 0.590 0.240 0.447 D260N Neutral Neutral Neutral Neutral Neutral 4 F[D]=47% F[N]=4% Nali=381 0.218 0.183 0.330 0.180 0.322 V261I Neutral Neutral Neutral Neutral Neutral 4 F[V]=55% F[I]=6% Nali=391 0.172 0.093 0.180 0.125 0.289 G262S Neutral Neutral Neutral Neutral Neutral 4 F[G]=36% F[S]=3% Nali=347 0.302 0.161 0.710 0.155 0.280 G262V Neutral Neutral Neutral Neutral Neutral 4 F[G]=36% F[V]=4% Nali=347 0.457 0.162 0.290 0.120 0.303 S263C Neutral Neutral Disease Neutral Neutral 4 F[S]=21% F[C]=0% Nali=372 0.477 0.137 0.040 0.260 0.315 S263P Neutral Neutral Neutral Neutral Neutral 1 F[S]=21% F[P]=2% Nali=372 0.293 0.273 0.330 0.070 0.446 D264A Neutral Neutral Neutral Neutral Neutral 1 F[D]=49% F[A]=2% Nali=374 0.214 0.358 0.120 0.430 0.458 E265D Neutral Neutral Neutral Neutral Neutral 5 F[E]=57% F[D]=14% Nali=398 0.119 0.135 0.640 0.130 0.256 E265V Neutral Neutral Neutral Neutral Neutral 1 F[E]=57% F[V]=4% Nali=398 0.396 0.378 0.390 0.335 0.454 E266D Neutral Neutral Neutral Neutral Neutral 4 F[E]=48% F[D]=18% Nali=404 0.181 0.097 0.200 0.235 0.311 E266G Neutral Neutral Disease Disease Neutral 0 F[E]=48% F[G]=2% Nali=404 0.244 0.276 0.030 0.605 0.478 E267K Neutral Neutral Neutral Neutral Neutral 5 F[E]=38% F[K]=13% Nali=408 0.173 0.174 0.660 0.245 0.258 E267Q Neutral Neutral Neutral Neutral Neutral 4 F[E]=38% F[Q]=1% Nali=408 0.218 0.139 0.410 0.195 0.310 E268A Neutral Neutral Neutral Neutral Neutral 5 F[E]=38% F[A]=4% Nali=414 0.282 0.121 0.660 0.335 0.259 E268D Neutral Neutral Neutral Neutral Neutral 5 F[E]=38% F[D]=21% Nali=414 0.149 0.057 0.720 0.130 0.265 E268G Neutral Neutral Neutral Neutral Neutral 4 F[E]=38% F[G]=3% Nali=414 0.474 0.166 0.380 0.305 0.318 E268K Neutral Neutral Neutral Neutral Neutral 5 F[E]=38% F[K]=17% Nali=414 0.272 0.122 0.890 0.185 0.260 E268Q Neutral Neutral Neutral Neutral Neutral 4 F[E]=38% F[Q]=2% Nali=414 0.367 0.117 0.460 0.270 0.318 K269N Neutral Neutral Neutral Neutral Neutral 3 F[K]=29% F[N]=2% Nali=405 0.235 0.121 0.160 0.220 0.326 K269R Neutral Neutral Neutral Neutral Neutral 4 F[K]=29% F[R]=1% Nali=405 0.233 0.062 0.170 0.270 0.281 K270E Neutral Neutral Neutral Neutral Neutral 5 F[K]=42% F[E]=21% Nali=404 0.130 0.072 0.920 0.185 0.257 K270M Disease Neutral Neutral Neutral Neutral 3 F[K]=42% F[M]=0% Nali=404 0.585 0.134 0.060 0.350 0.373 K270N Neutral Neutral Neutral Neutral Neutral 4 F[K]=42% F[N]=2% Nali=404 0.306 0.171 0.320 0.345 0.316 K270R Neutral Neutral Neutral Neutral Neutral 4 F[K]=42% F[R]=1% Nali=404 0.297 0.088 0.330 0.300 0.306 D271E Neutral Neutral Neutral Neutral Neutral 6 F[D]=33% F[E]=21% Nali=377 0.187 0.039 0.940 0.115 0.210 D271G Neutral Neutral Neutral Neutral Neutral 2 F[D]=33% F[G]=2% Nali=377 0.321 0.194 0.100 0.445 0.385 D271H Neutral Neutral Disease Disease Neutral 4 F[D]=33% F[H]=0% Nali=377 0.466 0.104 0.040 0.535 0.314 D271N Neutral Neutral Neutral Neutral Neutral 4 F[D]=33% F[N]=2% Nali=377 0.309 0.141 0.180 0.210 0.312 D271Y Disease Neutral Disease Disease Disease 1 F[D]=33% F[Y]=1% Nali=377 0.596 0.281 0.010 0.520 0.541 G272A Neutral Neutral Neutral Neutral Neutral 5 F[G]=32% F[A]=5% Nali=369 0.172 0.036 0.240 0.120 0.255 G272C Disease Neutral Disease Neutral Neutral 2 F[G]=32% F[C]=0% Nali=369 0.681 0.125 0.010 0.360 0.386 G272D Neutral Neutral Neutral Neutral Neutral 5 F[G]=32% F[D]=7% Nali=369 0.167 0.144 0.530 0.170 0.266 G272R Neutral Neutral Neutral Neutral Neutral 3 F[G]=32% F[R]=0% Nali=369 0.214 0.135 0.110 0.370 0.336 G272S Neutral Neutral Neutral Neutral Neutral 4 F[G]=32% F[S]=2% Nali=369 0.179 0.084 0.180 0.220 0.299 G272V Neutral Neutral Neutral Neutral Neutral 4 F[G]=32% F[V]=3% Nali=369 0.337 0.085 0.060 0.260 0.280 D273A Neutral Neutral Neutral Neutral Neutral 4 F[D]=29% F[A]=2% Nali=370 0.246 0.089 0.310 0.400 0.301 D273E Neutral Neutral Neutral Neutral Neutral 5 F[D]=29% F[E]=13% Nali=370 0.138 0.043 0.710 0.145 0.247 D273G Neutral Neutral Neutral Neutral Neutral 4 F[D]=29% F[G]=3% Nali=370 0.377 0.157 0.290 0.305 0.303 D273V Neutral Neutral Neutral Neutral Neutral 4 F[D]=29% F[V]=2% Nali=370 0.309 0.137 0.110 0.385 0.313 D273Y Disease Neutral Disease Disease Disease 1 F[D]=29% F[Y]=0% Nali=370 0.558 0.232 0.010 0.525 0.525 K274M Disease Neutral Disease Disease Neutral 4 F[K]=53% F[M]=1% Nali=405 0.749 0.158 0.020 0.565 0.290 K274N Neutral Neutral Neutral Neutral Neutral 3 F[K]=53% F[N]=3% Nali=405 0.358 0.186 0.090 0.490 0.348 K275N Disease Neutral Disease Disease Neutral 1 F[K]=63% F[N]=1% Nali=408 0.511 0.363 0.020 0.570 0.464 K275R Neutral Neutral Disease Disease Neutral 3 F[K]=63% F[R]=2% Nali=408 0.397 0.188 0.020 0.520 0.363 K276M Disease Neutral Disease Disease Disease 3 F[K]=66% F[M]=0% Nali=406 0.894 0.352 0.000 0.580 0.650 K276R Neutral Neutral Neutral Neutral Neutral 2 F[K]=66% F[R]=4% Nali=406 0.435 0.203 0.070 0.290 0.377 K276T Disease Neutral Disease Neutral Disease 2 F[K]=66% F[T]=3% Nali=406 0.770 0.312 0.050 0.490 0.598 K277E Neutral Neutral Neutral Neutral Neutral 3 F[K]=42% F[E]=5% Nali=407 0.250 0.190 0.480 0.330 0.352 K277N Neutral Neutral Neutral Neutral Neutral 1 F[K]=42% F[N]=1% Nali=407 0.347 0.246 0.210 0.435 0.455 K277R Neutral Neutral Neutral Neutral Neutral 4 F[K]=42% F[R]=1% Nali=407 0.331 0.150 0.270 0.380 0.317 K277T Neutral Neutral Neutral Neutral Neutral 6 F[K]=42% F[T]=25% Nali=407 0.194 0.065 0.990 0.195 0.220 K278M Disease Neutral Disease Disease Disease 3 F[K]=68% F[M]=0% Nali=406 0.834 0.347 0.000 0.605 0.640 K278R Neutral Neutral Neutral Neutral Neutral 2 F[K]=68% F[R]=3% Nali=406 0.399 0.223 0.100 0.320 0.415 K279M Disease Neutral Neutral Neutral Disease 1 F[K]=50% F[M]=1% Nali=401 0.812 0.264 0.090 0.310 0.556 K279N Disease Neutral Neutral Neutral Disease 2 F[K]=50% F[N]=1% Nali=401 0.655 0.337 0.050 0.460 0.595 I280M Disease Neutral Disease Disease Neutral 1 F[I]=40% F[M]=1% Nali=402 0.518 0.410 0.020 0.555 0.463 K281E Neutral Neutral Neutral Neutral Neutral 1 F[K]=49% F[E]=9% Nali=408 0.207 0.291 0.260 0.335 0.433 K281M Disease Neutral Disease Neutral Disease 2 F[K]=49% F[M]=0% Nali=408 0.699 0.339 0.030 0.415 0.609 K281N Neutral Neutral Neutral Neutral Neutral 0 F[K]=49% F[N]=1% Nali=408 0.430 0.398 0.110 0.320 0.478 K281R Neutral Neutral Disease Neutral Neutral 1 F[K]=49% F[R]=1% Nali=408 0.418 0.262 0.050 0.470 0.467 E282G Neutral Neutral Disease Disease Disease 0 F[E]=56% F[G]=0% Nali=420 0.425 0.425 0.030 0.560 0.507 E282K Neutral Neutral Neutral Neutral Neutral 1 F[E]=56% F[K]=18% Nali=420 0.189 0.303 0.470 0.280 0.451 E282Q Neutral Neutral Neutral Neutral Neutral 0 F[E]=56% F[Q]=2% Nali=420 0.442 0.330 0.080 0.260 0.484 E282V Disease Neutral Neutral Neutral Disease 1 F[E]=56% F[V]=3% Nali=420 0.542 0.434 0.170 0.340 0.556 K283T Neutral Neutral Neutral Neutral Neutral 5 F[K]=40% F[T]=14% Nali=408 0.152 0.127 0.710 0.210 0.269 Y284D Neutral Disease Neutral Neutral Neutral 0 F[Y]=47% F[D]=1% Nali=441 0.490 0.557 0.220 0.475 0.499 Y284N Neutral Disease Neutral Neutral Disease 1 F[Y]=47% F[N]=0% Nali=441 0.452 0.513 0.280 0.425 0.550 I285F Neutral Neutral Neutral Neutral Neutral 1 F[I]=20% F[F]=2% Nali=464 0.397 0.285 0.700 0.115 0.463 I285M Neutral Neutral Neutral Neutral Neutral 1 F[I]=20% F[M]=1% Nali=464 0.433 0.233 0.230 0.120 0.459 I285N Neutral Disease Neutral Neutral Neutral 1 F[I]=20% F[N]=2% Nali=464 0.307 0.576 0.330 0.265 0.468 I285V Neutral Neutral Neutral Neutral Neutral 5 F[I]=20% F[V]=16% Nali=464 0.274 0.063 0.520 0.220 0.252 D286E Neutral Neutral Neutral Neutral Neutral 5 F[D]=33% F[E]=43% Nali=485 0.183 0.053 1.000 0.215 0.230 D286H Disease Neutral Disease Disease Disease 2 F[D]=33% F[H]=0% Nali=485 0.764 0.282 0.000 0.665 0.617 D286N Neutral Neutral Disease Neutral Neutral 6 F[D]=33% F[N]=5% Nali=485 0.499 0.297 0.030 0.480 0.179 D286V Disease Neutral Disease Disease Disease 4 F[D]=33% F[V]=1% Nali=485 0.796 0.428 0.020 0.645 0.685 D286Y Disease Disease Disease Disease Disease 5 F[D]=33% F[Y]=0% Nali=485 0.862 0.568 0.000 0.655 0.740 Q287E Neutral Neutral Neutral Neutral Neutral 3 F[Q]=9% F[E]=13% Nali=573 0.238 0.124 0.100 0.165 0.330 Q287K Neutral Neutral Neutral Neutral Neutral 1 F[Q]=9% F[K]=1% Nali=573 0.289 0.302 0.060 0.320 0.461 Q287R Neutral Neutral Neutral Neutral Neutral 1 F[Q]=9% F[R]=1% Nali=573 0.384 0.280 0.080 0.355 0.446 E288D Disease Disease Neutral Neutral Neutral 1 F[E]=77% F[D]=3% Nali=667 0.610 0.521 0.070 0.200 0.471 E288K Neutral Disease Disease Disease Disease 1 F[E]=77% F[K]=4% Nali=667 0.418 0.717 0.040 0.565 0.560 E288Q Disease Neutral Neutral Neutral Neutral 0 F[E]=77% F[Q]=6% Nali=667 0.536 0.482 0.070 0.215 0.482 E289D Disease Neutral Neutral Neutral Neutral 3 F[E]=24% F[D]=0% Nali=714 0.508 0.241 0.250 0.300 0.344 E289G Disease Neutral Neutral Neutral Disease 1 F[E]=24% F[G]=0% Nali=714 0.610 0.272 0.360 0.470 0.552 E289K Neutral Neutral Neutral Neutral Neutral 1 F[E]=24% F[K]=6% Nali=714 0.324 0.315 0.360 0.255 0.465 E289Q Neutral Neutral Neutral Neutral Neutral 4 F[E]=24% F[Q]=16% Nali=714 0.315 0.089 0.360 0.165 0.308 L290H Disease Disease Disease Disease Disease 4 F[L]=45% F[H]=0% Nali=806 0.819 0.612 0.000 0.590 0.719 L290P Disease Disease Disease Disease Disease 6 F[L]=45% F[P]=0% Nali=806 0.823 0.825 0.000 0.660 0.775 N291I Disease Disease Disease Disease Disease 7 F[N]=97% F[I]=0% Nali=833 0.988 0.800 0.000 0.730 0.845 N291K Disease Disease Disease Disease Disease 7 F[N]=97% F[K]=0% Nali=833 0.969 0.765 0.000 0.735 0.835 N291S Disease Disease Disease Disease Disease 6 F[N]=97% F[S]=1% Nali=833 0.955 0.704 0.000 0.700 0.802 N291T Disease Disease Disease Disease Disease 6 F[N]=97% F[T]=1% Nali=833 0.968 0.769 0.010 0.650 0.800 N291Y Disease Disease Disease Disease Disease 7 F[N]=97% F[Y]=0% Nali=833 0.985 0.819 0.000 0.755 0.863 K292E Neutral Disease Neutral Neutral Neutral 1 F[K]=42% F[E]=7% Nali=829 0.270 0.508 0.390 0.215 0.444 K292R Neutral Neutral Neutral Neutral Neutral 0 F[K]=42% F[R]=3% Nali=829 0.444 0.330 0.160 0.160 0.483 T293A Neutral Neutral Neutral Neutral Neutral 5 F[T]=26% F[A]=23% Nali=827 0.441 0.072 1.000 0.115 0.269 T293I Neutral Neutral Neutral Neutral Neutral 1 F[T]=26% F[I]=4% Nali=827 0.260 0.276 0.190 0.310 0.447 T293K Neutral Neutral Neutral Neutral Disease 1 F[T]=26% F[K]=1% Nali=827 0.465 0.473 0.890 0.280 0.526 T293P Disease Disease Neutral Neutral Disease 0 F[T]=26% F[P]=2% Nali=827 0.718 0.603 0.260 0.255 0.524 T293R Disease Disease Neutral Neutral Disease 1 F[T]=26% F[R]=1% Nali=827 0.553 0.506 0.540 0.215 0.533 T293S Neutral Neutral Neutral Neutral Neutral 1 F[T]=26% F[S]=2% Nali=827 0.370 0.245 0.710 0.230 0.455 K294M Disease Neutral Disease Disease Disease 4 F[K]=52% F[M]=0% Nali=832 0.871 0.458 0.000 0.605 0.685 K294N Disease Neutral Neutral Neutral Disease 1 F[K]=52% F[N]=5% Nali=832 0.642 0.490 0.060 0.375 0.560 P295A Neutral Neutral Neutral Neutral Neutral 5 F[P]=57% F[A]=41% Nali=835 0.378 0.121 0.820 0.250 0.255 P295H Disease Disease Disease Disease Disease 7 F[P]=57% F[H]=0% Nali=835 0.975 0.647 0.000 0.715 0.853 P295L Disease Disease Disease Disease Disease 6 F[P]=57% F[L]=0% Nali=835 0.949 0.642 0.010 0.600 0.825 P295R Disease Disease Disease Disease Disease 7 F[P]=57% F[R]=0% Nali=835 0.956 0.745 0.000 0.720 0.835 P295S Disease Disease Disease Disease Disease 4 F[P]=57% F[S]=0% Nali=835 0.814 0.630 0.010 0.600 0.689 P295T Disease Disease Disease Disease Disease 4 F[P]=57% F[T]=0% Nali=835 0.859 0.620 0.000 0.610 0.710 I296M Disease Disease Disease Disease Disease 4 F[I]=49% F[M]=0% Nali=841 0.792 0.563 0.000 0.605 0.702 I296N Disease Disease Disease Disease Disease 7 F[I]=49% F[N]=0% Nali=841 0.951 0.861 0.000 0.605 0.844 W297C Disease Disease Disease Disease Disease 7 F[W]=99% F[C]=0% Nali=845 0.991 0.866 0.000 0.755 0.856 W297L Disease Disease Disease Disease Disease 6 F[W]=99% F[L]=0% Nali=845 0.969 0.798 0.000 0.740 0.818 W297R Disease Disease Disease Disease Disease 8 F[W]=99% F[R]=0% Nali=845 0.983 0.871 0.000 0.795 0.892 W297S Disease Disease Disease Disease Disease 7 F[W]=99% F[S]=0% Nali=845 0.981 0.905 0.000 0.745 0.844 T298A Neutral Neutral Neutral Neutral Neutral 1 F[T]=51% F[A]=7% Nali=844 0.379 0.237 0.340 0.150 0.453 T298I Disease Neutral Disease Neutral Disease 2 F[T]=51% F[I]=1% Nali=844 0.593 0.472 0.030 0.435 0.608 T298N Disease Disease Neutral Neutral Neutral 0 F[T]=51% F[N]=1% Nali=844 0.501 0.577 0.090 0.300 0.484 T298S Neutral Neutral Neutral Neutral Neutral 1 F[T]=51% F[S]=2% Nali=844 0.476 0.383 0.150 0.155 0.448 R299K Neutral Neutral Neutral Neutral Neutral 2 F[R]=74% F[K]=17% Nali=848 0.495 0.327 0.130 0.250 0.377 R299T Disease Disease Disease Disease Disease 4 F[R]=74% F[T]=0% Nali=848 0.776 0.789 0.000 0.625 0.710 N300D Neutral Neutral Neutral Neutral Neutral 3 F[N]=34% F[D]=6% Nali=842 0.327 0.214 0.610 0.175 0.365 N300I Disease Neutral Neutral Neutral Disease 3 F[N]=34% F[I]=0% Nali=842 0.655 0.418 0.050 0.335 0.627 N300K Neutral Neutral Neutral Neutral Neutral 3 F[N]=34% F[K]=14% Nali=842 0.251 0.199 0.700 0.190 0.365 N300S Neutral Neutral Neutral Neutral Neutral 5 F[N]=34% F[S]=17% Nali=842 0.279 0.134 0.890 0.150 0.270 P301A Neutral Neutral Neutral Neutral Neutral 1 F[P]=48% F[A]=3% Nali=839 0.451 0.345 0.090 0.370 0.464 P301H Disease Disease Disease Disease Disease 2 F[P]=48% F[H]=0% Nali=839 0.758 0.552 0.010 0.520 0.582 P301L Disease Disease Disease Neutral Disease 0 F[P]=48% F[L]=0% Nali=839 0.697 0.597 0.010 0.440 0.508 P301R Disease Disease Neutral Neutral Neutral 0 F[P]=48% F[R]=6% Nali=839 0.549 0.581 0.230 0.345 0.497 P301S Neutral Disease Neutral Neutral Neutral 1 F[P]=48% F[S]=3% Nali=839 0.408 0.510 0.140 0.220 0.456 P301T Disease Disease Disease Neutral Neutral 0 F[P]=48% F[T]=1% Nali=839 0.615 0.537 0.040 0.470 0.483 D302A Neutral Neutral Neutral Neutral Neutral 1 F[D]=19% F[A]=6% Nali=845 0.358 0.291 0.260 0.250 0.454 D302E Neutral Neutral Neutral Neutral Neutral 4 F[D]=19% F[E]=15% Nali=845 0.263 0.183 0.700 0.120 0.318 D302G Disease Neutral Neutral Neutral Disease 2 F[D]=19% F[G]=1% Nali=845 0.556 0.389 0.100 0.365 0.607 D302H Disease Neutral Disease Neutral Disease 2 F[D]=19% F[H]=0% Nali=845 0.598 0.331 0.020 0.455 0.607 D302N Neutral Neutral Neutral Neutral Neutral 3 F[D]=19% F[N]=11% Nali=845 0.336 0.214 0.420 0.145 0.364 D302V Disease Neutral Disease Neutral Disease 2 F[D]=19% F[V]=0% Nali=845 0.586 0.447 0.050 0.415 0.609 D302Y Disease Disease Disease Neutral Disease 0 F[D]=19% F[Y]=0% Nali=845 0.713 0.540 0.010 0.455 0.507 D303E Neutral Neutral Neutral Neutral Neutral 5 F[D]=43% F[E]=49% Nali=849 0.256 0.135 1.000 0.145 0.267 D303G Disease Disease Disease Neutral Disease 2 F[D]=43% F[G]=0% Nali=849 0.676 0.762 0.000 0.500 0.623 D303H Disease Disease Disease Disease Disease 4 F[D]=43% F[H]=0% Nali=849 0.731 0.710 0.000 0.540 0.688 D303N Disease Disease Neutral Neutral Disease 0 F[D]=43% F[N]=2% Nali=849 0.564 0.705 0.090 0.275 0.507 D303V Disease Disease Disease Neutral Disease 4 F[D]=43% F[V]=0% Nali=849 0.733 0.813 0.030 0.495 0.701 D303Y Disease Disease Disease Disease Disease 5 F[D]=43% F[Y]=0% Nali=849 0.825 0.857 0.000 0.535 0.762 I304F Disease Disease Disease Disease Disease 4 F[I]=48% F[F]=0% Nali=849 0.736 0.739 0.000 0.555 0.693 I304N Disease Disease Disease Disease Disease 5 F[I]=48% F[N]=0% Nali=849 0.860 0.870 0.000 0.540 0.774 I304T Disease Disease Disease Disease Disease 4 F[I]=48% F[T]=0% Nali=849 0.688 0.745 0.000 0.545 0.687 T305I Disease Disease Disease Neutral Disease 0 F[T]=52% F[I]=0% Nali=850 0.778 0.650 0.040 0.435 0.515 T305N Neutral Disease Disease Neutral Disease 1 F[T]=52% F[N]=0% Nali=850 0.485 0.739 0.010 0.445 0.540 T305S Neutral Neutral Neutral Neutral Neutral 4 F[T]=52% F[S]=24% Nali=850 0.244 0.153 0.450 0.145 0.278 N306H Neutral Neutral Disease Neutral Neutral 3 F[N]=8% F[H]=1% Nali=850 0.488 0.125 0.010 0.220 0.338 N306I Disease Neutral Disease Neutral Disease 1 F[N]=8% F[I]=0% Nali=850 0.575 0.237 0.010 0.265 0.537 N306K Neutral Neutral Neutral Neutral Neutral 4 F[N]=8% F[K]=14% Nali=850 0.321 0.087 0.460 0.115 0.283 N306S Neutral Neutral Neutral Neutral Neutral 4 F[N]=8% F[S]=2% Nali=850 0.282 0.131 0.070 0.190 0.310 N306T Neutral Neutral Neutral Neutral Neutral 4 F[N]=8% F[T]=4% Nali=850 0.296 0.141 0.110 0.175 0.314 E307D Neutral Neutral Neutral Neutral Neutral 1 F[E]=75% F[D]=13% Nali=852 0.396 0.346 0.170 0.260 0.448 E307K Disease Disease Disease Neutral Disease 1 F[E]=75% F[K]=3% Nali=852 0.537 0.748 0.040 0.500 0.540 E307Q Disease Disease Disease Neutral Disease 0 F[E]=75% F[Q]=2% Nali=852 0.615 0.585 0.020 0.435 0.511 E308D Neutral Neutral Neutral Neutral Neutral 1 F[E]=72% F[D]=18% Nali=858 0.407 0.265 0.240 0.240 0.440 E308K Disease Disease Disease Disease Disease 3 F[E]=72% F[K]=1% Nali=858 0.501 0.777 0.030 0.545 0.638 E308Q Neutral Neutral Neutral Neutral Neutral 1 F[E]=72% F[Q]=8% Nali=858 0.434 0.458 0.080 0.290 0.455 E308V Disease Disease Disease Disease Disease 4 F[E]=72% F[V]=0% Nali=858 0.778 0.780 0.000 0.610 0.715 Y309F Disease Disease Disease Neutral Disease 2 F[Y]=95% F[F]=0% Nali=859 0.704 0.770 0.000 0.500 0.601 G310A Neutral Neutral Neutral Neutral Neutral 4 F[G]=14% F[A]=20% Nali=859 0.239 0.075 0.850 0.050 0.288 G310E Neutral Neutral Neutral Neutral Neutral 1 F[G]=14% F[E]=4% Nali=859 0.266 0.376 0.820 0.120 0.442 G310R Neutral Neutral Neutral Neutral Neutral 1 F[G]=14% F[R]=2% Nali=859 0.323 0.421 0.420 0.155 0.471 G310V Neutral Neutral Neutral Neutral Neutral 1 F[G]=14% F[V]=2% Nali=859 0.420 0.287 0.240 0.170 0.458 E311K Neutral Disease Neutral Neutral Neutral 0 F[E]=50% F[K]=5% Nali=860 0.343 0.588 0.170 0.350 0.477 E311Q Disease Neutral Neutral Neutral Neutral 2 F[E]=50% F[Q]=3% Nali=860 0.514 0.395 0.140 0.275 0.390 F312I Disease Disease Disease Disease Disease 5 F[F]=97% F[I]=0% Nali=866 0.834 0.784 0.000 0.660 0.749 F312L Disease Disease Disease Disease Disease 1 F[F]=97% F[L]=2% Nali=866 0.665 0.770 0.030 0.580 0.555 F312Y Disease Disease Disease Disease Disease 5 F[F]=97% F[Y]=0% Nali=866 0.796 0.772 0.000 0.620 0.725 Y313C Disease Disease Disease Disease Disease 6 F[Y]=95% F[C]=1% Nali=866 0.978 0.860 0.010 0.620 0.818 Y313D Disease Disease Disease Disease Disease 7 F[Y]=95% F[D]=0% Nali=866 0.976 0.863 0.000 0.730 0.843 Y313F Disease Disease Neutral Neutral Disease 0 F[Y]=95% F[F]=4% Nali=866 0.512 0.717 0.070 0.410 0.505 Y313H Disease Disease Disease Disease Disease 6 F[Y]=95% F[H]=0% Nali=866 0.908 0.787 0.000 0.730 0.802 K314E Disease Disease Disease Neutral Disease 2 F[K]=76% F[E]=1% Nali=868 0.510 0.788 0.010 0.475 0.597 K314M Disease Disease Disease Neutral Disease 2 F[K]=76% F[M]=1% Nali=868 0.842 0.658 0.020 0.415 0.577 K314N Neutral Disease Disease Neutral Disease 2 F[K]=76% F[N]=1% Nali=868 0.497 0.771 0.010 0.425 0.590 S315N Disease Disease Neutral Neutral Neutral 0 F[S]=38% F[N]=2% Nali=866 0.507 0.571 0.270 0.205 0.485 S315R Disease Disease Neutral Neutral Disease 0 F[S]=38% F[R]=0% Nali=866 0.569 0.689 0.220 0.415 0.519 L316F Disease Neutral Neutral Neutral Neutral 4 F[L]=41% F[F]=3% Nali=867 0.503 0.474 0.190 0.220 0.319 L316M Disease Neutral Disease Neutral Disease 3 F[L]=41% F[M]=0% Nali=867 0.712 0.350 0.030 0.345 0.647 T317A Neutral Neutral Neutral Neutral Neutral 1 F[T]=28% F[A]=14% Nali=861 0.257 0.232 0.430 0.165 0.431 T317I Disease Disease Neutral Neutral Disease 0 F[T]=28% F[I]=0% Nali=861 0.552 0.599 0.120 0.335 0.504 T317N Neutral Disease Neutral Neutral Disease 1 F[T]=28% F[N]=1% Nali=861 0.412 0.693 0.090 0.340 0.532 T317S Neutral Neutral Neutral Neutral Neutral 5 F[T]=28% F[S]=37% Nali=861 0.232 0.079 1.000 0.100 0.265 N318I Disease Disease Disease Neutral Disease 1 F[N]=41% F[I]=0% Nali=856 0.739 0.714 0.040 0.400 0.525 N318K Neutral Neutral Neutral Neutral Neutral 1 F[N]=41% F[K]=8% Nali=856 0.206 0.473 0.050 0.360 0.447 N318S Neutral Disease Neutral Neutral Neutral 0 F[N]=41% F[S]=1% Nali=856 0.468 0.521 0.160 0.310 0.499 D319E Neutral Disease Disease Neutral Neutral 1 F[D]=75% F[E]=5% Nali=856 0.292 0.667 0.050 0.445 0.473 D319H Disease Disease Disease Disease Disease 4 F[D]=75% F[H]=0% Nali=856 0.710 0.813 0.040 0.580 0.688 D319N Neutral Disease Neutral Neutral Disease 1 F[D]=75% F[N]=2% Nali=856 0.481 0.773 0.080 0.320 0.532 W320C Disease Disease Disease Disease Disease 5 F[W]=41% F[C]=0% Nali=855 0.802 0.811 0.020 0.680 0.773 W320R Neutral Disease Neutral Disease Disease 5 F[W]=41% F[R]=0% Nali=855 0.486 0.811 0.090 0.590 0.743 E321K Neutral Disease Neutral Neutral Disease 0 F[E]=51% F[K]=5% Nali=859 0.426 0.668 0.060 0.415 0.510 D322E Neutral Neutral Neutral Neutral Neutral 1 F[D]=52% F[E]=28% Nali=858 0.239 0.240 0.420 0.240 0.433 D322H Disease Disease Disease Disease Disease 4 F[D]=52% F[H]=0% Nali=858 0.721 0.715 0.000 0.665 0.701 D322N Disease Disease Neutral Neutral Disease 0 F[D]=52% F[N]=3% Nali=858 0.570 0.624 0.080 0.370 0.512 D322Y Disease Disease Disease Disease Disease 5 F[D]=52% F[Y]=0% Nali=858 0.813 0.865 0.000 0.660 0.771 H323D Disease Disease Neutral Neutral Disease 5 F[H]=32% F[D]=0% Nali=859 0.623 0.824 0.270 0.410 0.736 H323L Disease Disease Neutral Neutral Disease 3 F[H]=32% F[L]=0% Nali=859 0.547 0.798 0.100 0.410 0.672 H323N Disease Disease Neutral Neutral Disease 3 F[H]=32% F[N]=0% Nali=859 0.598 0.799 0.090 0.455 0.664 H323P Neutral Neutral Neutral Neutral Neutral 3 F[H]=32% F[P]=63% Nali=859 0.396 0.196 1.000 0.260 0.354 H323Q Disease Disease Neutral Neutral Neutral 0 F[H]=32% F[Q]=0% Nali=859 0.548 0.710 0.120 0.285 0.489 H323Y Neutral Disease Neutral Neutral Disease 0 F[H]=32% F[Y]=2% Nali=859 0.443 0.757 0.180 0.260 0.506 L324F Disease Disease Neutral Neutral Disease 1 F[L]=80% F[F]=2% Nali=859 0.781 0.680 0.050 0.350 0.543 L324M Disease Neutral Neutral Neutral Disease 1 F[L]=80% F[M]=4% Nali=859 0.555 0.463 0.060 0.320 0.569 A325G Disease Disease Disease Neutral Disease 0 F[A]=50% F[G]=1% Nali=856 0.727 0.503 0.050 0.425 0.510 A325S Neutral Neutral Neutral Neutral Neutral 0 F[A]=50% F[S]=7% Nali=856 0.457 0.423 0.070 0.295 0.484 A325T Neutral Neutral Neutral Neutral Neutral 0 F[A]=50% F[T]=7% Nali=856 0.439 0.435 0.060 0.325 0.478 A325V Disease Disease Neutral Neutral Neutral 0 F[A]=50% F[V]=1% Nali=856 0.587 0.527 0.070 0.365 0.493 V326A Neutral Disease Neutral Neutral Disease 0 F[V]=38% F[A]=0% Nali=855 0.435 0.539 0.930 0.185 0.524 V326E Neutral Disease Neutral Neutral Disease 5 F[V]=38% F[E]=0% Nali=855 0.362 0.843 0.430 0.365 0.771 V326L Neutral Disease Neutral Neutral Disease 1 F[V]=38% F[L]=0% Nali=855 0.471 0.578 0.320 0.330 0.525 K327R Disease Neutral Neutral Neutral Disease 2 F[K]=34% F[R]=0% Nali=853 0.646 0.374 0.350 0.410 0.624 L340F Disease Disease Disease Disease Disease 4 F[L]=64% F[F]=0% Nali=859 0.766 0.757 0.000 0.610 0.684 L340V Neutral Disease Neutral Neutral Neutral 1 F[L]=64% F[V]=8% Nali=859 0.297 0.550 0.100 0.320 0.464 L341V Disease Disease Disease Disease Disease 1 F[L]=89% F[V]=1% Nali=859 0.748 0.709 0.030 0.515 0.548 R345Q Neutral Neutral Neutral Neutral Neutral 1 F[R]=13% F[Q]=4% Nali=854 0.308 0.366 0.230 0.180 0.454 R346C Disease Disease Disease Neutral Disease 5 F[R]=44% F[C]=0% Nali=848 0.874 0.855 0.010 0.475 0.770 R346H Disease Disease Neutral Neutral Neutral 1 F[R]=44% F[H]=6% Nali=848 0.541 0.635 0.220 0.190 0.471 F349C Disease Disease Disease Disease Disease 5 F[F]=65% F[C]=0% Nali=814 0.757 0.894 0.010 0.600 0.742 D350V Disease Disease Disease Disease Disease 5 F[D]=82% F[V]=0% Nali=832 0.640 0.907 0.000 0.635 0.744 F352I Disease Disease Disease Disease Disease 2 F[F]=59% F[I]=2% Nali=828 0.652 0.770 0.010 0.545 0.576 E353G Disease Disease Neutral Neutral Disease 0 F[E]=53% F[G]=3% Nali=660 0.589 0.549 0.070 0.395 0.518 R355K Neutral Neutral Neutral Neutral Neutral 1 F[R]=35% F[K]=23% Nali=803 0.324 0.249 0.840 0.120 0.456 N359K Neutral Disease Neutral Neutral Neutral 1 F[N]=35% F[K]=5% Nali=827 0.287 0.540 0.760 0.180 0.436 K362R Neutral Disease Neutral Neutral Neutral 1 F[K]=73% F[R]=6% Nali=863 0.345 0.547 0.150 0.280 0.451 Y364C Disease Disease Disease Disease Disease 7 F[Y]=93% F[C]=0% Nali=866 0.984 0.890 0.010 0.680 0.842 V365I Disease Disease Disease Neutral Neutral 0 F[V]=79% F[I]=3% Nali=866 0.642 0.596 0.030 0.400 0.481 M371R Neutral Disease Disease Disease Disease 6 F[M]=60% F[R]=0% Nali=871 0.469 0.914 0.010 0.720 0.801 E375D Neutral Neutral Neutral Neutral Neutral 1 F[E]=54% F[D]=14% Nali=854 0.254 0.363 0.410 0.120 0.449 E375K Neutral Disease Neutral Neutral Neutral 0 F[E]=54% F[K]=12% Nali=854 0.397 0.697 0.170 0.225 0.482 E375Q Neutral Disease Neutral Neutral Neutral 0 F[E]=54% F[Q]=2% Nali=854 0.464 0.564 0.060 0.180 0.479 E376D Neutral Neutral Neutral Neutral Neutral 4 F[E]=39% F[D]=31% Nali=840 0.232 0.129 0.780 0.085 0.279 E376G Disease Disease Disease Disease Disease 0 F[E]=39% F[G]=3% Nali=840 0.544 0.566 0.020 0.505 0.504 L377V Disease Disease Disease Neutral Disease 0 F[L]=68% F[V]=5% Nali=861 0.681 0.628 0.010 0.480 0.518 I378N Disease Disease Disease Neutral Disease 7 F[I]=35% F[N]=0% Nali=861 0.944 0.850 0.000 0.450 0.832 P379L Disease Disease Disease Disease Disease 6 F[P]=99% F[L]=0% Nali=861 0.973 0.919 0.000 0.545 0.801 P379R Disease Disease Disease Disease Disease 6 F[P]=99% F[R]=0% Nali=861 0.965 0.928 0.000 0.670 0.790 E380A Disease Disease Neutral Neutral Disease 0 F[E]=44% F[A]=2% Nali=859 0.512 0.551 0.120 0.335 0.507 Y381H Disease Disease Disease Disease Disease 4 F[Y]=70% F[H]=1% Nali=858 0.637 0.846 0.020 0.530 0.678 Y381S Disease Disease Disease Disease Disease 6 F[Y]=70% F[S]=0% Nali=858 0.937 0.904 0.010 0.540 0.817 I385V Neutral Neutral Neutral Neutral Neutral 5 F[I]=26% F[V]=57% Nali=860 0.292 0.071 1.000 0.160 0.268 G387R Disease Disease Disease Disease Disease 6 F[G]=99% F[R]=0% Nali=857 0.967 0.903 0.000 0.725 0.815 V388L Disease Disease Neutral Neutral Neutral 1 F[V]=72% F[L]=10% Nali=857 0.579 0.627 0.120 0.260 0.473 V389I Neutral Neutral Neutral Neutral Neutral 2 F[V]=74% F[I]=22% Nali=858 0.477 0.279 0.260 0.225 0.387 S391A Disease Disease Neutral Neutral Neutral 1 F[S]=82% F[A]=5% Nali=857 0.596 0.611 0.100 0.280 0.471 S391L Disease Disease Disease Disease Disease 4 F[S]=82% F[L]=0% Nali=857 0.814 0.861 0.000 0.555 0.720 D393E Disease Disease Disease Disease Disease 1 F[D]=94% F[E]=2% Nali=858 0.625 0.804 0.040 0.510 0.529 D393G Disease Disease Disease Disease Disease 6 F[D]=94% F[G]=0% Nali=858 0.878 0.880 0.000 0.685 0.801 D393H Disease Disease Disease Disease Disease 7 F[D]=94% F[H]=0% Nali=858 0.927 0.881 0.000 0.710 0.827 D393N Disease Disease Disease Disease Disease 3 F[D]=94% F[N]=1% Nali=858 0.723 0.804 0.030 0.570 0.639 D393Y Disease Disease Disease Disease Disease 7 F[D]=94% F[Y]=0% Nali=858 0.964 0.930 0.000 0.700 0.831 I398V Neutral Neutral Neutral Neutral Neutral 5 F[I]=46% F[V]=50% Nali=858 0.272 0.052 1.000 0.150 0.234 E401D Disease Disease Disease Disease Disease 3 F[E]=93% F[D]=0% Nali=857 0.780 0.680 0.040 0.570 0.657 M402I Neutral Neutral Neutral Neutral Neutral 3 F[M]=29% F[I]=28% Nali=858 0.270 0.198 1.000 0.140 0.363 L403F Disease Disease Disease Disease Disease 4 F[L]=93% F[F]=0% Nali=858 0.748 0.763 0.000 0.580 0.682 Q405H Disease Disease Neutral Neutral Neutral 0 F[Q]=49% F[H]=7% Nali=856 0.637 0.521 0.170 0.190 0.478 K407R NA Neutral Neutral Neutral Neutral 6 F[K]=48% F[R]=24% Nali=856 - 0.208 0.590 0.105 0.203 I408T Neutral Disease Neutral Neutral Neutral 0 F[I]=43% F[T]=2% Nali=855 0.347 0.527 0.180 0.320 0.485 L409V Neutral Neutral Neutral Neutral Neutral 1 F[L]=53% F[V]=19% Nali=857 0.348 0.301 0.320 0.165 0.459 I412M Disease Disease Neutral Neutral Neutral 1 F[I]=81% F[M]=7% Nali=858 0.629 0.651 0.130 0.225 0.446 I412T Disease Disease Disease Disease Disease 4 F[I]=81% F[T]=0% Nali=858 0.684 0.807 0.000 0.545 0.682 K414E Disease Disease Neutral Neutral Neutral 0 F[K]=61% F[E]=4% Nali=850 0.534 0.615 0.050 0.265 0.479 K414R Disease Neutral Neutral Neutral Disease 2 F[K]=61% F[R]=7% Nali=850 0.591 0.320 0.160 0.170 0.606 V417I Neutral Neutral Neutral Neutral Neutral 1 F[V]=53% F[I]=6% Nali=850 0.397 0.380 0.100 0.195 0.471 V417L Disease Disease Disease Neutral Disease 0 F[V]=53% F[L]=0% Nali=850 0.589 0.736 0.040 0.400 0.512 C420R Disease Disease Disease Disease Disease 6 F[C]=25% F[R]=0% Nali=849 0.523 0.867 0.010 0.550 0.785 L421I Neutral Neutral Neutral Neutral Neutral 1 F[L]=66% F[I]=14% Nali=849 0.354 0.335 0.290 0.125 0.449 E422G Disease Neutral Neutral Neutral Disease 2 F[E]=37% F[G]=8% Nali=848 0.629 0.381 0.260 0.215 0.615 E422Q Neutral Neutral Neutral Neutral Neutral 1 F[E]=37% F[Q]=6% Nali=848 0.479 0.347 0.340 0.100 0.430 E422V Disease Disease Disease Neutral Disease 0 F[E]=37% F[V]=0% Nali=848 0.509 0.533 0.030 0.360 0.505 L423F Disease Neutral Neutral Neutral Disease 2 F[L]=38% F[F]=2% Nali=847 0.625 0.476 0.080 0.245 0.579 T425I Disease Neutral Neutral Neutral Neutral 1 F[T]=8% F[I]=1% Nali=844 0.580 0.195 0.090 0.145 0.434 A428V Disease Disease Disease Neutral Disease 1 F[A]=58% F[V]=1% Nali=834 0.687 0.713 0.040 0.385 0.527 E429D Neutral Neutral Neutral Neutral Neutral 1 F[E]=53% F[D]=10% Nali=835 0.427 0.490 0.180 0.150 0.465 E429G Disease Disease Disease Neutral Disease 1 F[E]=53% F[G]=0% Nali=835 0.592 0.751 0.050 0.465 0.561 E429K Neutral Disease Neutral Neutral Neutral 1 F[E]=53% F[K]=20% Nali=835 0.468 0.547 0.190 0.205 0.459 E429Q Neutral Disease Disease Neutral Disease 0 F[E]=53% F[Q]=2% Nali=835 0.429 0.623 0.040 0.280 0.504 D430E Neutral Disease Neutral Neutral Neutral 1 F[D]=57% F[E]=10% Nali=843 0.461 0.541 0.450 0.150 0.445 D430G Disease Disease Neutral Neutral Disease 3 F[D]=57% F[G]=1% Nali=843 0.596 0.834 0.200 0.335 0.671 D430N Neutral Neutral Neutral Neutral Neutral 1 F[D]=57% F[N]=23% Nali=843 0.341 0.453 0.770 0.140 0.455 K431R Neutral Neutral Neutral Neutral Neutral 1 F[K]=39% F[R]=17% Nali=845 0.371 0.229 0.190 0.135 0.450 E432D Neutral Neutral Neutral Neutral Neutral 1 F[E]=66% F[D]=19% Nali=843 0.356 0.417 0.420 0.185 0.449 N433K Neutral Neutral Neutral Neutral Neutral 5 F[N]=17% F[K]=29% Nali=847 0.327 0.094 1.000 0.135 0.253 N433S Neutral Neutral Neutral Neutral Neutral 2 F[N]=17% F[S]=5% Nali=847 0.277 0.197 0.250 0.240 0.381 Y434C Disease Disease Disease Disease Disease 7 F[Y]=80% F[C]=0% Nali=840 0.981 0.858 0.000 0.620 0.852 Y434H Disease Disease Disease Disease Disease 5 F[Y]=80% F[H]=0% Nali=840 0.905 0.753 0.000 0.610 0.763 K435R Neutral Neutral Neutral Neutral Neutral 1 F[K]=31% F[R]=4% Nali=853 0.382 0.262 0.230 0.130 0.458 K436E Neutral Disease Neutral Neutral Neutral 1 F[K]=56% F[E]=6% Nali=852 0.414 0.643 0.200 0.250 0.468 K436M Disease Disease Disease Neutral Disease 1 F[K]=56% F[M]=0% Nali=852 0.825 0.615 0.030 0.350 0.551 K436N Disease Disease Disease Neutral Disease 1 F[K]=56% F[N]=1% Nali=852 0.641 0.722 0.050 0.420 0.527 F437L Disease Disease Disease Neutral Disease 0 F[F]=89% F[L]=2% Nali=850 0.555 0.763 0.040 0.485 0.511 F437Y Disease Disease Disease Neutral Disease 1 F[F]=89% F[Y]=4% Nali=850 0.746 0.755 0.010 0.500 0.540 Y438F Neutral Disease Neutral Neutral Neutral 1 F[Y]=45% F[F]=5% Nali=851 0.384 0.564 0.090 0.240 0.463 Y438H Disease Disease Disease Disease Disease 4 F[Y]=45% F[H]=0% Nali=851 0.855 0.620 0.000 0.565 0.711 Q440P Disease Disease Disease Disease Disease 5 F[Q]=24% F[P]=0% Nali=852 0.564 0.815 0.030 0.580 0.773 S442C Disease Disease Disease Neutral Disease 4 F[S]=31% F[C]=0% Nali=853 0.911 0.745 0.000 0.445 0.704 S442F Disease Disease Disease Neutral Disease 5 F[S]=31% F[F]=0% Nali=853 0.853 0.818 0.000 0.490 0.762 I445L Neutral Neutral Neutral Neutral Neutral 5 F[I]=32% F[L]=58% Nali=852 0.260 0.140 1.000 0.120 0.272 I445M Neutral Neutral Neutral Neutral Neutral 1 F[I]=32% F[M]=3% Nali=852 0.350 0.498 0.080 0.200 0.453 I445V Neutral Neutral Disease Neutral Neutral 1 F[I]=32% F[V]=4% Nali=852 0.316 0.347 0.050 0.360 0.455 K446R Disease Disease Disease Disease Disease 1 F[K]=96% F[R]=1% Nali=853 0.584 0.704 0.020 0.525 0.558 G448A Disease Disease Disease Disease Disease 3 F[G]=98% F[A]=1% Nali=852 0.904 0.671 0.030 0.565 0.665 I449M Disease Neutral Disease Neutral Disease 2 F[I]=42% F[M]=2% Nali=842 0.592 0.409 0.030 0.305 0.619 I449T Disease Disease Disease Neutral Disease 0 F[I]=42% F[T]=0% Nali=842 0.777 0.613 0.040 0.495 0.516 E451K Disease Disease Disease Disease Disease 1 F[E]=72% F[K]=3% Nali=848 0.641 0.720 0.010 0.590 0.573 D452V Disease Disease Neutral Disease Disease 6 F[D]=90% F[V]=0% Nali=849 0.941 0.863 0.120 0.550 0.808 S453F Disease Neutral Neutral Neutral Disease 1 F[S]=30% F[F]=17% Nali=848 0.624 0.284 0.070 0.380 0.562 S453T Neutral Neutral Neutral Neutral Neutral 2 F[S]=30% F[T]=8% Nali=848 0.384 0.218 0.330 0.160 0.418 R456W Disease Disease Disease Disease Disease 7 F[R]=61% F[W]=0% Nali=846 0.949 0.889 0.020 0.520 0.826 K458Q Neutral Disease Neutral Neutral Neutral 1 F[K]=50% F[Q]=4% Nali=844 0.382 0.519 0.060 0.195 0.451 L459H Disease Disease Disease Disease Disease 6 F[L]=57% F[H]=0% Nali=840 0.949 0.702 0.000 0.555 0.820 L459V Neutral Neutral Neutral Neutral Neutral 2 F[L]=57% F[V]=5% Nali=840 0.493 0.381 0.060 0.180 0.420 S460L Neutral Neutral Neutral Neutral Neutral 1 F[S]=11% F[L]=11% Nali=843 0.266 0.322 0.140 0.135 0.452 E461G Disease Neutral Neutral Neutral Disease 1 F[E]=26% F[G]=7% Nali=845 0.589 0.236 0.210 0.275 0.551 E461Q Neutral Neutral Neutral Neutral Neutral 1 F[E]=26% F[Q]=2% Nali=845 0.444 0.221 0.160 0.140 0.426 L462F Disease Disease Neutral Neutral Neutral 1 F[L]=82% F[F]=7% Nali=846 0.566 0.529 0.060 0.280 0.475 L462P Disease Disease Disease Disease Disease 7 F[L]=82% F[P]=0% Nali=846 0.937 0.825 0.000 0.690 0.828 L462V Disease Disease Disease Neutral Disease 0 F[L]=82% F[V]=2% Nali=846 0.719 0.518 0.020 0.400 0.518 L463V Disease Neutral Neutral Neutral Disease 2 F[L]=77% F[V]=4% Nali=846 0.638 0.466 0.070 0.250 0.588 R464K Disease Disease Disease Neutral Disease 0 F[R]=78% F[K]=1% Nali=822 0.650 0.703 0.040 0.430 0.517 Y466C Disease Disease Neutral Neutral Disease 1 F[Y]=19% F[C]=0% Nali=831 0.794 0.669 0.120 0.320 0.554 T467A Disease Disease Disease Disease Disease 3 F[T]=33% F[A]=1% Nali=811 0.620 0.504 0.000 0.645 0.654 T467I Disease Disease Disease Disease Disease 6 F[T]=33% F[I]=0% Nali=811 0.895 0.721 0.000 0.630 0.780 T467K Disease Disease Disease Disease Disease 4 F[T]=33% F[K]=3% Nali=811 0.793 0.714 0.000 0.740 0.702 S468F Disease Disease Disease Disease Disease 5 F[S]=49% F[F]=0% Nali=834 0.780 0.780 0.020 0.640 0.726 A469G Disease Neutral Neutral Neutral Disease 2 F[A]=15% F[G]=1% Nali=831 0.576 0.345 0.060 0.190 0.606 A469V Disease Neutral Disease Neutral Disease 2 F[A]=15% F[V]=2% Nali=831 0.596 0.335 0.030 0.305 0.606 G471R Neutral Disease Disease Disease Disease 4 F[G]=43% F[R]=0% Nali=801 0.458 0.725 0.010 0.600 0.719 D472G Neutral Disease Neutral Neutral Neutral 0 F[D]=42% F[G]=8% Nali=800 0.298 0.571 0.200 0.335 0.477 D472V Disease Disease Neutral Neutral Disease 0 F[D]=42% F[V]=0% Nali=800 0.710 0.715 0.060 0.455 0.518 E473K Neutral Neutral Neutral Neutral Neutral 1 F[E]=44% F[K]=19% Nali=838 0.269 0.299 0.390 0.265 0.450 E473V Disease Disease Neutral Neutral Neutral 0 F[E]=44% F[V]=1% Nali=838 0.686 0.625 0.050 0.460 0.500 M474I Neutral Neutral Neutral Neutral Neutral 1 F[M]=20% F[I]=2% Nali=844 0.262 0.277 0.280 0.410 0.438 S476F Disease Disease Disease Disease Disease 6 F[S]=72% F[F]=0% Nali=849 0.932 0.779 0.010 0.595 0.801 S476Y Disease Disease Disease Disease Disease 6 F[S]=72% F[Y]=0% Nali=849 0.926 0.778 0.000 0.660 0.813 L477F Disease Disease Neutral Neutral Neutral 0 F[L]=87% F[F]=11% Nali=852 0.684 0.503 0.130 0.300 0.484 L477V Disease Disease Disease Neutral Disease 2 F[L]=87% F[V]=0% Nali=852 0.856 0.689 0.010 0.485 0.609 K478Q Neutral Neutral Neutral Neutral Neutral 1 F[K]=33% F[Q]=3% Nali=852 0.484 0.430 0.260 0.195 0.448 Y480C Disease Disease Disease Disease Disease 7 F[Y]=95% F[C]=1% Nali=849 0.985 0.871 0.000 0.725 0.832 C481G Neutral Disease Disease Neutral Disease 0 F[C]=3% F[G]=0% Nali=848 0.405 0.655 0.000 0.425 0.514 T482P Disease Disease Neutral Neutral Neutral 0 F[T]=16% F[P]=0% Nali=848 0.597 0.629 0.110 0.275 0.483 M484K Disease Disease Disease Disease Disease 5 F[M]=85% F[K]=1% Nali=853 0.819 0.878 0.020 0.645 0.728 M484V Disease Disease Disease Disease Disease 3 F[M]=85% F[V]=1% Nali=853 0.536 0.793 0.010 0.615 0.651 K485E Disease Disease Disease Neutral Disease 3 F[K]=69% F[E]=1% Nali=852 0.611 0.817 0.040 0.485 0.631 K485Q Disease Disease Neutral Neutral Neutral 1 F[K]=69% F[Q]=3% Nali=852 0.568 0.682 0.050 0.190 0.473 E486G Disease Disease Disease Neutral Disease 1 F[E]=68% F[G]=0% Nali=853 0.731 0.748 0.000 0.490 0.573 E486K Neutral Disease Neutral Neutral Neutral 0 F[E]=68% F[K]=2% Nali=853 0.477 0.805 0.090 0.240 0.498 Q488E Disease Disease Disease Disease Disease 3 F[Q]=94% F[E]=1% Nali=851 0.662 0.768 0.000 0.655 0.647 H490R Neutral Neutral Neutral Neutral Neutral 1 F[H]=8% F[R]=1% Nali=848 0.263 0.348 0.430 0.305 0.444 H490Y Disease Neutral Neutral Neutral Neutral 0 F[H]=8% F[Y]=4% Nali=848 0.540 0.353 0.120 0.250 0.499 I491M Disease Disease Disease Disease Disease 2 F[I]=92% F[M]=2% Nali=850 0.821 0.778 0.010 0.560 0.611 I491T Disease Disease Disease Disease Disease 5 F[I]=92% F[T]=0% Nali=850 0.805 0.888 0.010 0.595 0.740 Y492C Disease Disease Disease Disease Disease 6 F[Y]=87% F[C]=0% Nali=849 0.913 0.870 0.010 0.630 0.813 Y493C Disease Disease Disease Disease Disease 7 F[Y]=82% F[C]=0% Nali=846 0.968 0.877 0.000 0.650 0.841 Y493H Disease Disease Disease Disease Disease 6 F[Y]=82% F[H]=0% Nali=846 0.896 0.797 0.000 0.745 0.817 Y493N Disease Disease Disease Disease Disease 7 F[Y]=82% F[N]=0% Nali=846 0.939 0.882 0.000 0.670 0.830 I494V Neutral Neutral Neutral Neutral Neutral 1 F[I]=55% F[V]=12% Nali=845 0.473 0.293 0.220 0.245 0.448 T495A Neutral Neutral Neutral Neutral Neutral 2 F[T]=64% F[A]=13% Nali=846 0.223 0.228 0.280 0.330 0.400 E497D Neutral Neutral Neutral Neutral Neutral 4 F[E]=50% F[D]=28% Nali=823 0.379 0.152 0.550 0.150 0.286 E497K Neutral Disease Neutral Neutral Disease 1 F[E]=50% F[K]=2% Nali=823 0.443 0.710 0.100 0.315 0.537 E497Q Disease Disease Disease Neutral Disease 0 F[E]=50% F[Q]=1% Nali=823 0.556 0.515 0.030 0.360 0.501 T498I Disease Disease Disease Neutral Disease 1 F[T]=11% F[I]=0% Nali=819 0.654 0.599 0.010 0.500 0.526 K499E Disease Disease Neutral Neutral Disease 0 F[K]=27% F[E]=3% Nali=825 0.528 0.642 0.280 0.390 0.514 K499N Disease Disease Neutral Neutral Disease 0 F[K]=27% F[N]=1% Nali=825 0.622 0.524 0.300 0.355 0.517 K499Q Disease Neutral Neutral Neutral Disease 2 F[K]=27% F[Q]=1% Nali=825 0.588 0.427 0.290 0.330 0.615 D500E Neutral Neutral Neutral Neutral Neutral 5 F[D]=18% F[E]=23% Nali=843 0.202 0.163 1.000 0.070 0.268 D500H Neutral Neutral Disease Neutral Neutral 1 F[D]=18% F[H]=0% Nali=843 0.360 0.394 0.030 0.445 0.470 D500N Neutral Neutral Neutral Neutral Neutral 1 F[D]=18% F[N]=5% Nali=843 0.335 0.331 0.250 0.135 0.463 Q501R Neutral Neutral Neutral Neutral Neutral 1 F[Q]=19% F[R]=6% Nali=841 0.453 0.483 0.180 0.200 0.468 V502E Disease Disease Disease Disease Disease 5 F[V]=37% F[E]=1% Nali=831 0.759 0.853 0.000 0.575 0.751 N504H Neutral Neutral Neutral Neutral Neutral 0 F[N]=42% F[H]=4% Nali=838 0.405 0.364 0.130 0.250 0.477 S505L Disease Disease Neutral Neutral Disease 0 F[S]=80% F[L]=5% Nali=846 0.630 0.681 0.070 0.490 0.518 R510C Disease Disease Neutral Neutral Disease 2 F[R]=23% F[C]=0% Nali=849 0.876 0.707 0.050 0.315 0.577 R510H Disease Neutral Neutral Neutral Disease 3 F[R]=23% F[H]=1% Nali=849 0.663 0.430 0.130 0.240 0.627 L511V Neutral Neutral Neutral Neutral Neutral 1 F[L]=35% F[V]=16% Nali=848 0.446 0.378 0.360 0.120 0.472 R512Q Neutral Disease Neutral Neutral Neutral 0 F[R]=33% F[Q]=3% Nali=848 0.321 0.682 0.190 0.240 0.484 R512W Disease Disease Neutral Neutral Disease 5 F[R]=33% F[W]=0% Nali=848 0.836 0.893 0.110 0.260 0.743 K513E Neutral Disease Neutral Neutral Neutral 0 F[K]=51% F[E]=8% Nali=844 0.374 0.763 0.150 0.225 0.484 K513I Disease Disease Disease Neutral Disease 5 F[K]=51% F[I]=0% Nali=844 0.802 0.846 0.010 0.405 0.771 H514R Disease Neutral Neutral Neutral Neutral 6 F[H]=4% F[R]=25% Nali=846 0.500 0.426 0.420 0.180 0.179 H514Y Disease Disease Disease Neutral Disease 1 F[H]=4% F[Y]=1% Nali=846 0.542 0.721 0.000 0.485 0.551 L516V Neutral Neutral Neutral Neutral Neutral 1 F[L]=11% F[V]=7% Nali=840 0.277 0.457 0.210 0.075 0.458 E517K Disease Disease Disease Disease Disease 6 F[E]=89% F[K]=0% Nali=847 0.810 0.882 0.000 0.700 0.798 E517Q Disease Disease Disease Disease Disease 4 F[E]=89% F[Q]=0% Nali=847 0.827 0.719 0.000 0.620 0.704 V518E Disease Disease Disease Disease Disease 7 F[V]=91% F[E]=0% Nali=846 0.971 0.899 0.000 0.690 0.846 I519M Disease Disease Disease Neutral Disease 0 F[I]=17% F[M]=0% Nali=843 0.700 0.625 0.000 0.435 0.501 I519S Disease Disease Disease Neutral Disease 5 F[I]=17% F[S]=0% Nali=843 0.909 0.824 0.000 0.475 0.763 Y520C Disease Disease Disease Disease Disease 7 F[Y]=36% F[C]=0% Nali=841 0.947 0.825 0.000 0.550 0.836 M521K Disease Disease Disease Disease Disease 6 F[M]=38% F[K]=0% Nali=845 0.685 0.887 0.000 0.670 0.790 M521T Disease Disease Disease Disease Disease 4 F[M]=38% F[T]=1% Nali=845 0.500 0.801 0.000 0.595 0.714 M521V Neutral Disease Disease Disease Disease 5 F[M]=38% F[V]=0% Nali=845 0.329 0.818 0.020 0.595 0.753 I522T Neutral Neutral Neutral Neutral Neutral 5 F[I]=7% F[T]=39% Nali=846 0.351 0.110 1.000 0.130 0.250 E523D Neutral Neutral Neutral Neutral Neutral 5 F[E]=32% F[D]=61% Nali=847 0.331 0.057 1.000 0.195 0.253 P524S Neutral Disease Neutral Neutral Disease 0 F[P]=56% F[S]=2% Nali=846 0.476 0.694 0.130 0.270 0.503 E527D Disease Disease Disease Neutral Disease 1 F[E]=83% F[D]=3% Nali=847 0.740 0.663 0.040 0.400 0.542 V530G Disease Disease Disease Disease Disease 4 F[V]=37% F[G]=0% Nali=846 0.862 0.725 0.010 0.535 0.715 E537K Neutral Neutral Neutral Neutral Neutral 1 F[E]=30% F[K]=14% Nali=823 0.280 0.407 0.380 0.215 0.454 G538A Disease Neutral Neutral Neutral Disease 1 F[G]=69% F[A]=1% Nali=822 0.551 0.477 0.090 0.310 0.569 K539N Disease Disease Neutral Neutral Neutral 0 F[K]=83% F[N]=0% Nali=822 0.697 0.714 0.110 0.400 0.487 K539R Disease Disease Neutral Neutral Neutral 1 F[K]=83% F[R]=1% Nali=822 0.683 0.571 0.130 0.345 0.471 T540I Disease Neutral Disease Neutral Disease 1 F[T]=8% F[I]=0% Nali=822 0.667 0.236 0.000 0.330 0.552 T540P Disease Neutral Disease Neutral Disease 2 F[T]=8% F[P]=14% Nali=822 0.631 0.372 0.020 0.350 0.620 L541S Disease Disease Disease Disease Disease 6 F[L]=61% F[S]=0% Nali=820 0.953 0.795 0.000 0.550 0.823 L541V Disease Disease Neutral Neutral Neutral 0 F[L]=61% F[V]=1% Nali=820 0.650 0.587 0.070 0.235 0.483 G548D Neutral Neutral Neutral Neutral Neutral 1 F[G]=46% F[D]=28% Nali=780 0.330 0.224 0.740 0.220 0.429 L551F Neutral Neutral Neutral Neutral Neutral 1 F[L]=67% F[F]=10% Nali=802 0.353 0.245 0.070 0.210 0.447 P552L Neutral Neutral Neutral Neutral Neutral 3 F[P]=23% F[L]=3% Nali=757 0.256 0.108 0.160 0.300 0.332 P552T Neutral Neutral Neutral Neutral Neutral 3 F[P]=23% F[T]=1% Nali=757 0.265 0.095 0.360 0.120 0.348 E553A Neutral Neutral Neutral Neutral Neutral 1 F[E]=55% F[A]=4% Nali=786 0.468 0.288 0.080 0.435 0.453 E553Q Neutral Neutral Neutral Neutral Neutral 1 F[E]=55% F[Q]=4% Nali=786 0.476 0.287 0.170 0.215 0.435 D554N Neutral Neutral Neutral Neutral Neutral 1 F[D]=39% F[N]=4% Nali=803 0.295 0.237 0.220 0.205 0.445 E555D Neutral Neutral Neutral Neutral Neutral 3 F[E]=61% F[D]=15% Nali=801 0.439 0.187 0.260 0.195 0.350 E557K Neutral Neutral Neutral Neutral Neutral 0 F[E]=59% F[K]=5% Nali=799 0.335 0.470 0.190 0.270 0.476 K559R Disease Neutral Neutral Neutral Disease 0 F[K]=52% F[R]=1% Nali=788 0.555 0.218 0.080 0.165 0.505 K560E Neutral Neutral Neutral Neutral Neutral 4 F[K]=31% F[E]=14% Nali=793 0.290 0.139 0.380 0.210 0.304 Q561K Neutral Neutral Neutral Neutral Neutral 4 F[Q]=18% F[K]=12% Nali=788 0.221 0.078 0.770 0.110 0.305 E562K Neutral Disease Neutral Neutral Neutral 1 F[E]=68% F[K]=9% Nali=791 0.390 0.520 0.430 0.225 0.432 E563D Neutral Neutral Neutral Neutral Neutral 0 F[E]=58% F[D]=5% Nali=802 0.435 0.337 0.090 0.265 0.476 E563K Neutral Neutral Neutral Neutral Neutral 1 F[E]=58% F[K]=11% Nali=802 0.313 0.464 0.310 0.215 0.457 K564E Neutral Neutral Neutral Neutral Neutral 6 F[K]=10% F[E]=14% Nali=791 0.240 0.061 1.000 0.100 0.218 K564R Neutral Neutral Neutral Neutral Neutral 5 F[K]=10% F[R]=2% Nali=791 0.305 0.042 0.510 0.155 0.235 T566K Neutral Neutral Neutral Neutral Neutral 5 F[T]=9% F[K]=21% Nali=782 0.346 0.108 1.000 0.075 0.252 E569D Neutral Neutral Neutral Neutral Neutral 2 F[E]=52% F[D]=6% Nali=795 0.492 0.372 0.150 0.155 0.422 N570K Neutral Neutral Neutral Neutral Neutral 1 F[N]=13% F[K]=6% Nali=800 0.221 0.258 0.450 0.115 0.427 L571F Disease Disease Neutral Neutral Neutral 1 F[L]=79% F[F]=7% Nali=809 0.658 0.527 0.070 0.265 0.474 I574M Neutral Neutral Neutral Neutral Neutral 4 F[I]=4% F[M]=0% Nali=811 0.447 0.179 0.220 0.155 0.311 I574V Neutral Neutral Neutral Neutral Neutral 5 F[I]=4% F[V]=13% Nali=811 0.226 0.060 0.550 0.160 0.231 M575T Disease Disease Disease Neutral Disease 0 F[M]=33% F[T]=1% Nali=813 0.597 0.543 0.010 0.495 0.510 M575V Neutral Neutral Neutral Neutral Neutral 1 F[M]=33% F[V]=11% Nali=813 0.371 0.332 0.470 0.210 0.467 D577E Neutral Neutral Neutral Neutral Neutral 5 F[D]=28% F[E]=32% Nali=817 0.230 0.104 1.000 0.060 0.263 I578K Neutral Disease Neutral Neutral Neutral 1 F[I]=28% F[K]=3% Nali=815 0.282 0.645 0.430 0.385 0.472 I578M Disease Neutral Neutral Neutral Disease 2 F[I]=28% F[M]=0% Nali=815 0.642 0.316 0.060 0.290 0.618 I578T Neutral Neutral Neutral Neutral Neutral 1 F[I]=28% F[T]=12% Nali=815 0.294 0.268 0.660 0.150 0.439 E580D Neutral Neutral Neutral Neutral Neutral 4 F[E]=8% F[D]=17% Nali=811 0.240 0.098 0.840 0.055 0.289 K581E Neutral Neutral Neutral Neutral Neutral 3 F[K]=14% F[E]=20% Nali=814 0.203 0.210 0.390 0.125 0.372 K581R Neutral Neutral Neutral Neutral Neutral 2 F[K]=14% F[R]=0% Nali=814 0.401 0.206 0.060 0.195 0.414 K582E Neutral Disease Neutral Neutral Neutral 0 F[K]=56% F[E]=6% Nali=817 0.463 0.575 0.130 0.310 0.482 K582Q Neutral Neutral Neutral Neutral Neutral 1 F[K]=56% F[Q]=8% Nali=817 0.476 0.386 0.140 0.235 0.446 V583I Neutral Neutral Neutral Neutral Neutral 2 F[V]=83% F[I]=12% Nali=817 0.343 0.355 0.180 0.220 0.412 V586A Neutral Disease Neutral Neutral Neutral 1 F[V]=92% F[A]=5% Nali=810 0.450 0.550 0.060 0.370 0.456 V586L Disease Disease Disease Disease Disease 1 F[V]=92% F[L]=1% Nali=810 0.517 0.651 0.000 0.550 0.563 V587A Neutral Neutral Neutral Neutral Neutral 1 F[V]=25% F[A]=2% Nali=807 0.407 0.243 0.700 0.230 0.458 V587L Disease Neutral Neutral Neutral Disease 1 F[V]=25% F[L]=2% Nali=807 0.556 0.244 0.290 0.200 0.551 V588L Neutral Neutral Neutral Neutral Neutral 4 F[V]=44% F[L]=19% Nali=811 0.337 0.154 0.530 0.125 0.282 V593A Neutral Neutral Neutral Neutral Neutral 1 F[V]=37% F[A]=6% Nali=808 0.294 0.229 0.230 0.220 0.427 T594K Neutral Neutral Neutral Neutral Neutral 1 F[T]=12% F[K]=1% Nali=814 0.285 0.298 0.110 0.215 0.456 I599V Neutral Neutral Neutral Neutral Neutral 4 F[I]=25% F[V]=15% Nali=813 0.225 0.136 0.290 0.155 0.308 S602T Neutral Neutral Neutral Neutral Neutral 6 F[S]=32% F[T]=2% Nali=808 0.500 0.290 0.290 0.180 0.215 W606C Disease Disease Disease Disease Disease 6 F[W]=45% F[C]=0% Nali=783 0.820 0.893 0.020 0.700 0.802 T607A Neutral Disease Disease Disease Disease 1 F[T]=26% F[A]=1% Nali=794 0.243 0.581 0.020 0.520 0.538 A608E Disease Disease Disease Disease Disease 4 F[A]=47% F[E]=1% Nali=791 0.554 0.859 0.030 0.630 0.724 A608T Disease Disease Neutral Neutral Disease 0 F[A]=47% F[T]=6% Nali=791 0.604 0.620 0.090 0.360 0.509 N609K Neutral Disease Disease Disease Disease 4 F[N]=48% F[K]=0% Nali=790 0.483 0.760 0.020 0.650 0.723 N609Y Disease Disease Neutral Neutral Disease 3 F[N]=48% F[Y]=2% Nali=790 0.827 0.777 0.100 0.380 0.644 M610I Disease Disease Disease Disease Disease 4 F[M]=79% F[I]=0% Nali=791 0.637 0.819 0.010 0.535 0.696 I613M Neutral Neutral Neutral Neutral Neutral 1 F[I]=54% F[M]=14% Nali=787 0.385 0.411 0.220 0.175 0.468 I613T Neutral Disease Disease Neutral Disease 2 F[I]=54% F[T]=1% Nali=787 0.410 0.764 0.020 0.490 0.609 M614V Disease Disease Disease Neutral Disease 2 F[M]=60% F[V]=1% Nali=776 0.655 0.772 0.050 0.470 0.587 K615R Disease Neutral Neutral Neutral Neutral 2 F[K]=62% F[R]=12% Nali=736 0.512 0.413 0.310 0.155 0.383 Q617L Disease Disease Neutral Neutral Disease 5 F[Q]=68% F[L]=0% Nali=642 0.548 0.884 0.100 0.410 0.748 A618T Neutral Disease Neutral Neutral Disease 0 F[A]=60% F[T]=5% Nali=643 0.489 0.775 0.180 0.150 0.509 D621G Disease Disease Neutral Neutral Disease 2 F[D]=63% F[G]=4% Nali=621 0.561 0.849 0.100 0.475 0.602 D621N Neutral Disease Neutral Neutral Disease 1 F[D]=63% F[N]=5% Nali=621 0.425 0.735 0.140 0.365 0.569 N622S Neutral Neutral Neutral Neutral Neutral 1 F[N]=24% F[S]=20% Nali=608 0.283 0.301 1.000 0.190 0.459 N622T Neutral Neutral Neutral Neutral Neutral 1 F[N]=24% F[T]=12% Nali=608 0.305 0.427 0.570 0.195 0.456 M625I Neutral Disease Neutral Neutral Neutral 0 F[M]=29% F[I]=2% Nali=573 0.432 0.573 0.470 0.460 0.491 M625V Neutral Neutral Neutral Neutral Neutral 1 F[M]=29% F[V]=5% Nali=573 0.302 0.483 0.610 0.450 0.468 M628I Neutral Disease Neutral Neutral Disease 1 F[M]=51% F[I]=6% Nali=599 0.427 0.700 0.230 0.465 0.575 A629V Neutral Neutral Neutral Neutral Neutral 1 F[A]=26% F[V]=8% Nali=615 0.358 0.414 0.300 0.135 0.468 A630T Neutral Disease Neutral Neutral Neutral 1 F[A]=29% F[T]=3% Nali=671 0.440 0.585 0.260 0.160 0.470 H633Q Neutral Disease Disease Neutral Neutral 0 F[H]=15% F[Q]=2% Nali=711 0.242 0.561 0.050 0.465 0.476 L634V Disease Disease Disease Disease Disease 3 F[L]=69% F[V]=1% Nali=749 0.637 0.755 0.020 0.565 0.636 I636M Disease Disease Disease Neutral Disease 1 F[I]=65% F[M]=0% Nali=748 0.832 0.644 0.040 0.435 0.536 I636V Disease Neutral Neutral Neutral Disease 1 F[I]=65% F[V]=11% Nali=748 0.547 0.297 0.190 0.280 0.574 P638L Disease Disease Disease Disease Disease 1 F[P]=79% F[L]=2% Nali=749 0.537 0.784 0.020 0.580 0.574 P638S Disease Disease Disease Disease Disease 3 F[P]=79% F[S]=1% Nali=749 0.604 0.752 0.010 0.605 0.641 H640D Disease Disease Disease Disease Disease 6 F[H]=84% F[D]=0% Nali=745 0.767 0.833 0.000 0.725 0.778 S641F Disease Disease Disease Neutral Disease 1 F[S]=12% F[F]=0% Nali=746 0.704 0.572 0.010 0.400 0.533 I642V Disease Neutral Neutral Neutral Neutral 4 F[I]=44% F[V]=10% Nali=745 0.508 0.199 0.310 0.230 0.284 I643F Disease Disease Neutral Neutral Disease 0 F[I]=40% F[F]=9% Nali=743 0.720 0.528 0.190 0.200 0.502 E644A Neutral Neutral Neutral Neutral Neutral 4 F[E]=17% F[A]=6% Nali=689 0.328 0.147 0.340 0.260 0.313 E644D Neutral Neutral Neutral Neutral Neutral 2 F[E]=17% F[D]=4% Nali=689 0.389 0.200 0.240 0.170 0.396 K649R Neutral Neutral Neutral Neutral Neutral 4 F[K]=33% F[R]=23% Nali=666 0.230 0.082 0.360 0.195 0.312 A650T Neutral Neutral Neutral Neutral Neutral 1 F[A]=32% F[T]=2% Nali=664 0.332 0.335 0.380 0.130 0.473 A650V Neutral Neutral Neutral Neutral Neutral 4 F[A]=32% F[V]=20% Nali=664 0.200 0.170 0.290 0.235 0.315 E651A Neutral Neutral Neutral Neutral Neutral 4 F[E]=37% F[A]=10% Nali=667 0.359 0.164 0.780 0.180 0.286 A652G Disease Neutral Neutral Neutral Disease 2 F[A]=42% F[G]=4% Nali=671 0.573 0.382 0.260 0.105 0.609 A652T Neutral Neutral Neutral Neutral Neutral 1 F[A]=42% F[T]=5% Nali=671 0.260 0.311 0.150 0.195 0.462 A652V Disease Neutral Neutral Neutral Neutral 4 F[A]=42% F[V]=3% Nali=671 0.504 0.347 0.070 0.220 0.305 K654E Neutral Neutral Neutral Neutral Neutral 1 F[K]=34% F[E]=12% Nali=677 0.273 0.251 0.600 0.235 0.442 N655K Neutral Neutral Neutral Neutral Neutral 1 F[N]=31% F[K]=3% Nali=659 0.285 0.342 0.910 0.160 0.465 D656N Neutral Disease Neutral Neutral Neutral 1 F[D]=64% F[N]=5% Nali=660 0.476 0.557 0.110 0.235 0.464 K657N Neutral Neutral Neutral Neutral Neutral 6 F[K]=40% F[N]=1% Nali=662 0.499 0.398 0.190 0.260 0.216 K657R Neutral Neutral Neutral Neutral Neutral 1 F[K]=40% F[R]=4% Nali=662 0.415 0.267 0.230 0.215 0.458 S658C Disease Neutral Disease Neutral Disease 2 F[S]=16% F[C]=0% Nali=669 0.761 0.320 0.050 0.350 0.623 S658T Neutral Neutral Neutral Neutral Neutral 5 F[S]=16% F[T]=20% Nali=669 0.235 0.056 0.680 0.090 0.260 V659M Disease Disease Neutral Neutral Disease 0 F[V]=40% F[M]=1% Nali=700 0.683 0.545 0.130 0.150 0.510 D661E Neutral Neutral Neutral Neutral Neutral 1 F[D]=59% F[E]=12% Nali=707 0.289 0.466 0.390 0.170 0.468 V663A Neutral Neutral Neutral Neutral Neutral 5 F[V]=33% F[A]=33% Nali=716 0.207 0.151 1.000 0.120 0.259 I664M Neutral Neutral Neutral Neutral Neutral 4 F[I]=7% F[M]=6% Nali=716 0.455 0.117 0.210 0.080 0.324 L666H Disease Disease Disease Disease Disease 7 F[L]=88% F[H]=0% Nali=728 0.978 0.818 0.000 0.680 0.850 L666V Neutral Disease Disease Neutral Neutral 1 F[L]=88% F[V]=2% Nali=728 0.483 0.610 0.040 0.460 0.475 Y667C Disease Disease Disease Disease Disease 7 F[Y]=34% F[C]=0% Nali=730 0.972 0.834 0.000 0.615 0.868 Y667D Disease Disease Disease Disease Disease 7 F[Y]=34% F[D]=0% Nali=730 0.971 0.871 0.000 0.670 0.864 T669P Disease Disease Disease Disease Disease 6 F[T]=42% F[P]=0% Nali=731 0.786 0.884 0.030 0.620 0.778 A670V Disease Disease Disease Neutral Disease 5 F[A]=86% F[V]=1% Nali=731 0.919 0.761 0.030 0.480 0.741 S677R Neutral Disease Neutral Neutral Disease 0 F[S]=33% F[R]=1% Nali=678 0.403 0.510 0.170 0.370 0.510 E679K Neutral Neutral Neutral Neutral Neutral 1 F[E]=41% F[K]=9% Nali=703 0.311 0.445 0.340 0.255 0.468 A685G Neutral Disease Neutral Neutral Neutral 0 F[A]=47% F[G]=6% Nali=675 0.301 0.598 0.100 0.380 0.483 N686D Neutral Neutral Neutral Neutral Neutral 1 F[N]=18% F[D]=5% Nali=672 0.222 0.318 0.310 0.260 0.447 Y689F Disease Disease Neutral Neutral Neutral 1 F[Y]=22% F[F]=3% Nali=639 0.575 0.559 0.670 0.175 0.473 Y689S Neutral Disease Neutral Neutral Neutral 0 F[Y]=22% F[S]=2% Nali=639 0.399 0.660 0.360 0.370 0.488 K693R Neutral Neutral Neutral Neutral Neutral 1 F[K]=53% F[R]=12% Nali=383 0.238 0.434 0.420 0.125 0.459 G697A Neutral Disease Neutral Neutral Neutral 0 F[G]=50% F[A]=2% Nali=314 0.246 0.563 0.060 0.360 0.482 G697S Neutral Neutral Neutral Neutral Neutral 1 F[G]=50% F[S]=21% Nali=314 0.196 0.343 0.340 0.185 0.435 I698V Neutral Neutral Neutral Neutral Neutral 3 F[I]=71% F[V]=16% Nali=281 0.223 0.226 0.510 0.180 0.367 D699E Neutral Disease Neutral Neutral Neutral 1 F[D]=76% F[E]=6% Nali=254 0.318 0.581 0.260 0.275 0.431 D701A Neutral Disease Neutral Neutral Neutral 0 F[D]=70% F[A]=3% Nali=224 0.411 0.556 0.120 0.410 0.478 D701E Neutral Neutral Neutral Neutral Neutral 2 F[D]=70% F[E]=20% Nali=224 0.236 0.255 0.310 0.260 0.387 D701G Neutral Disease Disease Disease Disease 2 F[D]=70% F[G]=1% Nali=224 0.426 0.699 0.050 0.560 0.622 D701H Disease Disease Disease Disease Disease 3 F[D]=70% F[H]=0% Nali=224 0.618 0.651 0.010 0.575 0.666 D701N Neutral Disease Neutral Neutral Neutral 1 F[D]=70% F[N]=4% Nali=224 0.420 0.559 0.140 0.325 0.472 D701Y Disease Disease Disease Disease Disease 4 F[D]=70% F[Y]=0% Nali=224 0.731 0.776 0.000 0.575 0.696 D702G Neutral Disease Neutral Neutral Disease 0 F[D]=37% F[G]=1% Nali=192 0.369 0.514 0.250 0.425 0.520 D702N Neutral Neutral Neutral Neutral Neutral 1 F[D]=37% F[N]=1% Nali=192 0.267 0.422 0.300 0.350 0.426 P703S Neutral Neutral Neutral Neutral Neutral 5 F[P]=34% F[S]=6% Nali=177 0.188 0.199 0.690 0.220 0.270 P703T Neutral Neutral Neutral Neutral Neutral 7 F[P]=34% F[T]=6% Nali=177 0.144 0.139 0.560 0.110 0.160 T704A Neutral Neutral Neutral Neutral Neutral 7 F[T]=25% F[A]=16% Nali=186 0.144 0.056 0.810 0.100 0.127 T704I Neutral Neutral Neutral Neutral Neutral 6 F[T]=25% F[I]=5% Nali=186 0.232 0.160 0.240 0.130 0.179 T704S Neutral Neutral Neutral Neutral Neutral 7 F[T]=25% F[S]=4% Nali=186 0.213 0.135 0.700 0.100 0.165 A705D Neutral Neutral Neutral Neutral Neutral 2 F[A]=32% F[D]=9% Nali=193 0.142 0.338 0.620 0.180 0.388 D706G Neutral Neutral Neutral Neutral Neutral 2 F[D]=32% F[G]=2% Nali=196 0.274 0.393 0.410 0.330 0.422 D707E Neutral Neutral Neutral Neutral Neutral 7 F[D]=31% F[E]=40% Nali=191 0.202 0.059 1.000 0.115 0.127 D707G Neutral Neutral Neutral Neutral Neutral 1 F[D]=31% F[G]=2% Nali=191 0.385 0.421 0.330 0.385 0.441 D707N Neutral Neutral Neutral Neutral Neutral 2 F[D]=31% F[N]=2% Nali=191 0.281 0.267 0.430 0.200 0.406 T708I Neutral Neutral Neutral Neutral Neutral 7 F[T]=17% F[I]=3% Nali=186 0.106 0.089 0.190 0.290 0.127 A710G Neutral Neutral Neutral Neutral Neutral 2 F[A]=42% F[G]=4% Nali=181 0.366 0.230 0.370 0.250 0.380 A710T Neutral Neutral Neutral Neutral Neutral 5 F[A]=42% F[T]=5% Nali=181 0.185 0.185 0.550 0.125 0.269 A710V Neutral Neutral Neutral Neutral Neutral 4 F[A]=42% F[V]=4% Nali=181 0.257 0.210 0.300 0.170 0.306 A711T Neutral Neutral Neutral Neutral Neutral 5 F[A]=45% F[T]=5% Nali=181 0.246 0.195 0.530 0.125 0.275 A711V Neutral Neutral Neutral Neutral Neutral 4 F[A]=45% F[V]=4% Nali=181 0.216 0.213 0.360 0.155 0.297 V712A Neutral Neutral Neutral Neutral Neutral 7 F[V]=32% F[A]=17% Nali=179 0.141 0.067 0.740 0.090 0.141 V712I Neutral Neutral Neutral Neutral Neutral 7 F[V]=32% F[I]=7% Nali=179 0.285 0.068 0.180 0.220 0.126 E714D Neutral Neutral Neutral Neutral Neutral 8 F[E]=37% F[D]=26% Nali=185 0.149 0.062 0.960 0.100 0.096 E714Q Neutral Neutral Neutral Neutral Neutral 6 F[E]=37% F[Q]=2% Nali=185 0.225 0.167 0.380 0.290 0.200 M716I Neutral Neutral Neutral Neutral Neutral 6 F[M]=35% F[I]=13% Nali=201 0.128 0.118 0.220 0.180 0.203 M716L Neutral Neutral Neutral Neutral Neutral 6 F[M]=35% F[L]=15% Nali=201 0.127 0.131 0.310 0.290 0.188 P717L Neutral Neutral Neutral Neutral Neutral 1 F[P]=80% F[L]=0% Nali=200 0.321 0.483 0.250 0.295 0.463 P717S Neutral Neutral Neutral Neutral Neutral 2 F[P]=80% F[S]=2% Nali=200 0.173 0.472 0.640 0.120 0.399 P718A Neutral Neutral Neutral Neutral Neutral 6 F[P]=64% F[A]=9% Nali=195 0.162 0.180 0.760 0.100 0.206 P718L Neutral Neutral Neutral Neutral Neutral 2 F[P]=64% F[L]=3% Nali=195 0.292 0.381 0.320 0.140 0.418 P718S Neutral Neutral Neutral Neutral Neutral 2 F[P]=64% F[S]=2% Nali=195 0.233 0.405 0.730 0.175 0.409 D723H Neutral Neutral Disease Disease Neutral 2 F[D]=35% F[H]=1% Nali=171 0.342 0.322 0.020 0.535 0.405 D724H Disease Neutral Neutral Disease Disease 0 F[D]=67% F[H]=0% Nali=173 0.520 0.487 0.110 0.520 0.507 D724N Neutral Neutral Neutral Neutral Neutral 2 F[D]=67% F[N]=2% Nali=173 0.343 0.372 0.460 0.290 0.407 T725K Neutral Neutral Neutral Neutral Neutral 2 F[T]=18% F[K]=1% Nali=170 0.134 0.313 0.290 0.395 0.381 T725P Neutral Neutral Neutral Neutral Neutral 2 F[T]=18% F[P]=2% Nali=170 0.304 0.392 0.100 0.470 0.403 R727C Disease Neutral Neutral Neutral Neutral 1 F[R]=48% F[C]=2% Nali=175 0.696 0.339 0.080 0.450 0.459 R727G Neutral Neutral Neutral Neutral Neutral 2 F[R]=48% F[G]=1% Nali=175 0.332 0.263 0.230 0.495 0.379 R727H Neutral Neutral Neutral Neutral Neutral 6 F[R]=48% F[H]=5% Nali=175 0.219 0.168 0.260 0.310 0.178 R727L Neutral Neutral Neutral Disease Neutral 2 F[R]=48% F[L]=1% Nali=175 0.254 0.361 0.320 0.530 0.390 M728I Neutral Neutral Disease Disease Neutral 2 F[M]=93% F[I]=2% Nali=181 0.457 0.297 0.020 0.660 0.386 M728V Neutral Neutral Disease Disease Neutral 3 F[M]=93% F[V]=2% Nali=181 0.298 0.314 0.030 0.665 0.368 E730V Neutral Neutral Neutral Neutral Neutral 2 F[E]=92% F[V]=0% Nali=180 0.397 0.328 0.130 0.275 0.406 D732Y Disease Neutral Disease Disease Disease 1 F[D]=97% F[Y]=0% Nali=174 0.780 0.349 0.000 0.635 0.546 Mutation: WT+POS+NEW WT: Residue in wild-type protein POS: Residue position NEW: New residue after mutation Prediction: Neutral: Neutral variants Disease: Disease causing variants Outputs: Value reported under each prediction PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease) PhD-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease) SIFT: Positive Value (If >0.05 mutation is predicted Neutral) SNAP: Output normailzed between 0 and 1 (If >0.5 mutation is predicted Disease) Meta-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease) RI: Reliability Index between 0 an 10 F[X]: Frequency of residue X in the sequence profile Nali: Number of aligned sequences in the mutated site