Meta-SNP: Meta-predictor of disease causing variants
  Cite: Capriotti et al. BMC Genomics 2013. Suppl 3:S2.
  WEB: http://snps.biofold.org/meta-snp


  Sequence File: sp.seq

  Mutation   PANTHER   PhD-SNP      SIFT      SNAP  Meta-SNP   RI   Profile
    W1258R        NA   Neutral   Neutral   Disease   Neutral    5   F[W]=11%  F[R]=9%   Nali=255
                   -     0.272     0.090     0.655     0.262
    R1276L        NA   Disease   Neutral   Disease   Disease    5   F[R]=99%  F[L]=0%   Nali=288
                   -     0.887     0.670     0.690     0.760
    R1276Q        NA   Disease   Neutral   Disease   Disease    5   F[R]=99%  F[Q]=0%   Nali=288
                   -     0.821     0.320     0.775     0.763
    N1278I        NA   Disease   Disease   Disease   Disease    6   F[N]=88%  F[I]=0%   Nali=287
                   -     0.879     0.030     0.715     0.787
    N1278K        NA   Disease   Neutral   Disease   Disease    6   F[N]=88%  F[K]=0%   Nali=287
                   -     0.853     0.220     0.725     0.775
    S1282R        NA   Disease   Disease   Disease   Disease    6   F[S]=38%  F[R]=0%   Nali=287
                   -     0.894     0.020     0.720     0.809
    I1284R        NA   Disease   Neutral   Disease   Disease    5   F[I]=12%  F[R]=0%   Nali=286
                   -     0.700     0.110     0.580     0.739
    K1290N        NA   Disease   Disease   Disease   Disease    4   F[K]=67%  F[N]=1%   Nali=287
                   -     0.871     0.010     0.630     0.711
    R1325K        NA   Neutral   Neutral   Neutral   Neutral    6   F[R]=35%  F[K]=62%  Nali=277
                   -     0.054     0.670     0.315     0.181
    R1325M        NA   Neutral   Disease   Disease   Neutral    4   F[R]=35%  F[M]=0%   Nali=277
                   -     0.372     0.030     0.655     0.320
    R1325T        NA   Neutral   Neutral   Neutral   Neutral    5   F[R]=35%  F[T]=0%   Nali=277
                   -     0.445     0.560     0.425     0.266
    L1339R        NA   Disease   Disease   Disease   Disease    6   F[L]=89%  F[R]=0%   Nali=283
                   -     0.858     0.010     0.765     0.792
    Q1370P        NA   Disease   Neutral   Disease   Disease    4   F[Q]=30%  F[P]=0%   Nali=191
                   -     0.732     0.170     0.550     0.707
    L1411R        NA   Disease   Neutral   Disease   Disease    6   F[L]=99%  F[R]=0%   Nali=287
                   -     0.960     0.070     0.685     0.821


  Mutation: WT+POS+NEW
    WT: Residue in wild-type protein
    POS: Residue position
    NEW: New residue after mutation
  Prediction:
    Neutral: Neutral variants
    Disease: Disease causing variants
  Outputs: Value reported under each prediction
    PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    PhD-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    SIFT: Positive Value (If >0.05 mutation is predicted Neutral)
    SNAP: Output normailzed between 0 and 1 (If >0.5 mutation is predicted Disease)
    Meta-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
  RI: Reliability Index between 0 an 10
  F[X]: Frequency of residue X in the sequence profile
  Nali: Number of aligned sequences in the mutated site