Meta-SNP: Meta-predictor of disease causing variants
  Cite: Capriotti et al. BMC Genomics 2013. Suppl 3:S2.
  WEB: http://snps.biofold.org/meta-snp


  Sequence File: SP.seq

  Mutation   PANTHER   PhD-SNP      SIFT      SNAP  Meta-SNP   RI   Profile
      P34S   Disease   Neutral   Disease   Disease   Disease    3   F[P]=95%  F[S]=1%   Nali=702
               0.788     0.406     0.010     0.765     0.646
     L142S   Neutral   Disease   Disease   Disease   Disease    4   F[L]=18%  F[S]=0%   Nali=945
               0.499     0.711     0.000     0.555     0.692
     L254P   Disease   Disease   Neutral   Neutral   Disease    0   F[L]=13%  F[P]=0%   Nali=935
               0.719     0.729     0.250     0.380     0.501
     L271P   Disease   Disease   Disease   Disease   Disease    6   F[L]=21%  F[P]=0%   Nali=979
               0.800     0.787     0.000     0.625     0.783
     L314P   Disease   Disease   Disease   Disease   Disease    6   F[L]=79%  F[P]=0%   Nali=992
               0.894     0.832     0.000     0.735     0.787
     P412L   Disease   Disease   Disease   Disease   Disease    5   F[P]=96%  F[L]=0%   Nali=979
               0.867     0.835     0.000     0.635     0.773
     K429E   Disease   Disease   Disease   Disease   Disease    2   F[K]=65%  F[E]=1%   Nali=980
               0.658     0.735     0.050     0.585     0.612
     R441C   Disease   Disease   Disease   Disease   Disease    7   F[R]=99%  F[C]=0%   Nali=966
               0.890     0.857     0.000     0.815     0.847


  Mutation: WT+POS+NEW
    WT: Residue in wild-type protein
    POS: Residue position
    NEW: New residue after mutation
  Prediction:
    Neutral: Neutral variants
    Disease: Disease causing variants
  Outputs: Value reported under each prediction
    PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    PhD-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    SIFT: Positive Value (If >0.05 mutation is predicted Neutral)
    SNAP: Output normailzed between 0 and 1 (If >0.5 mutation is predicted Disease)
    Meta-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
  RI: Reliability Index between 0 an 10
  F[X]: Frequency of residue X in the sequence profile
  Nali: Number of aligned sequences in the mutated site