Meta-SNP: Meta-predictor of disease causing variants
  Cite: Capriotti et al. BMC Genomics 2013. Suppl 3:S2.
  WEB: http://snps.biofold.org/meta-snp


  Sequence File: sp.seq

  Mutation   PANTHER   PhD-SNP      SIFT      SNAP  Meta-SNP   RI   Profile
      G36A   Neutral   Neutral   Neutral   Neutral   Neutral    8   F[G]=31%  F[A]=33%  Nali=48
               0.148     0.094     0.180     0.260     0.085
      G36D   Neutral   Neutral   Disease   Disease   Neutral    1   F[G]=31%  F[D]=4%   Nali=48
               0.417     0.497     0.010     0.635     0.452
      Q75H   Disease   Neutral   Disease   Disease   Neutral    6   F[Q]=42%  F[H]=4%   Nali=56
               0.577     0.166     0.000     0.615     0.208
     R125M   Disease   Disease   Neutral   Disease   Disease    5   F[R]=95%  F[M]=0%   Nali=109
               0.931     0.724     0.090     0.610     0.755
     R127Q   Neutral   Neutral   Neutral   Disease   Neutral    2   F[R]=33%  F[Q]=0%   Nali=110
               0.429     0.446     0.070     0.545     0.388


  Mutation: WT+POS+NEW
    WT: Residue in wild-type protein
    POS: Residue position
    NEW: New residue after mutation
  Prediction:
    Neutral: Neutral variants
    Disease: Disease causing variants
  Outputs: Value reported under each prediction
    PANTHER: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    PhD-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
    SIFT: Positive Value (If >0.05 mutation is predicted Neutral)
    SNAP: Output normailzed between 0 and 1 (If >0.5 mutation is predicted Disease)
    Meta-SNP: Between 0 and 1. (If >0.5 mutation is predicted Disease)
  RI: Reliability Index between 0 an 10
  F[X]: Frequency of residue X in the sequence profile
  Nali: Number of aligned sequences in the mutated site