Protein Mutation Annotation PANTHER PhD-SNP SIFT SNAP Meta-SNP A0AV02 K541R Polymorphism 0.122 0.052 0.48 -19 0.012 A0AVF1 D310N Polymorphism 0.300 0.615 0.00 12 0.508 A0AVI2 I337T Polymorphism 0.184 0.219 0.11 25 0.292 A0AVI2 T682A Polymorphism 0.211 0.310 0.43 -38 0.145 A0AVI4 L83I Polymorphism NA 0.196 0.00 17 0.270 A0AVT1 A224T Polymorphism 0.173 0.163 0.43 0 0.200 A0FGR8 C210S Polymorphism 0.115 0.429 0.56 -7 0.172 A0FGR8 S638G Polymorphism 0.391 0.181 0.12 -22 0.264 A0FGR9 G416R Polymorphism 0.949 0.965 0.02 45 0.924 A0FGR9 P246Q Polymorphism 0.660 0.965 0.00 50 0.904 A0PG75 R110S Polymorphism 0.860 0.930 0.00 64 0.912 A0PJK1 A522V Polymorphism NA 0.367 0.55 -41 0.228 A0PJW6 T28A Polymorphism 0.083 0.216 0.66 18 0.132 A0PJW8 A66T Polymorphism NA 0.029 0.58 -19 0.022 A0PJW8 L60P Polymorphism NA 0.397 0.05 -24 0.216 A0PJX8 R284H Polymorphism NA 0.429 0.00 51 0.658 A0PK11 A153T Polymorphism NA 0.191 0.17 -41 0.074 A0PK11 L113V Polymorphism NA 0.176 0.27 -38 0.139 A1A4F0 V4L Polymorphism NA 0.335 0.00 26 0.305 A1A4S6 M684V Polymorphism 0.208 0.091 0.41 34 0.112 A1A4S6 P488S Polymorphism 0.222 0.426 0.73 12 0.312 A1A4T8 P38L Polymorphism NA 0.206 NA 41 0.056 A1A4Y4 E17D Polymorphism NA 0.174 0.51 -41 0.131 A1A4Y4 T94K Polymorphism NA 0.705 0.12 36 0.782 A1A519 P173S Polymorphism NA 0.205 0.66 0 0.168 A1A5B4 F93L Polymorphism NA 0.057 NA -58 0.031 A1A5B4 C399R Polymorphism 0.438 0.753 0.36 9 0.458 A1A5B4 I391V Polymorphism 0.294 0.367 0.23 -38 0.193 A1IGU5 P489L Polymorphism 0.088 0.129 0.40 24 0.203 A1IGU5 P586T Polymorphism 0.111 0.052 0.79 -24 0.051 A1IGU5 S518R Polymorphism 0.148 0.402 0.09 50 0.540 A1KZ92 R583Q Polymorphism NA 0.204 0.31 51 0.368 A1KZ92 D1452E Polymorphism 0.048 0.101 0.00 -10 0.131 A1KZ92 V1327D Polymorphism 0.077 0.193 0.53 2 0.037 A1L157 V190A Polymorphism 0.120 0.331 1.00 3 0.163 A1L190 L88P Polymorphism NA 0.355 NA 8 0.082 A1L390 R1036W Polymorphism 0.199 0.206 NA 42 0.336 A1L453 M204V Polymorphism 0.101 0.135 1.00 -38 0.083 A1L4K1 E720K Polymorphism 0.289 0.509 0.25 34 0.678 A1L4L8 C11S Polymorphism NA 0.124 NA 26 0.024 A1Z1Q3 T58I Polymorphism 0.113 0.111 0.08 26 0.168 A2A368 L38F Polymorphism NA 0.074 0.63 -1 0.102 A2A368 C128Y Polymorphism 0.858 0.507 1.00 -15 0.138 A2A368 H161R Polymorphism 0.334 0.388 0.39 -7 0.234 A2A368 M248K Polymorphism 0.760 0.455 1.00 -37 0.026 A2A368 M248V Polymorphism 0.117 0.817 0.01 -6 0.592 A2A3L6 N550S Polymorphism 0.186 0.054 0.82 31 0.042 A2A3L6 P532A Polymorphism 0.240 0.102 0.00 26 0.155 A2CJ06 Y241C Polymorphism 0.936 0.970 0.00 64 0.962 A2PYH4 I939V Polymorphism 0.037 0.099 0.18 -67 0.120 A2PYH4 S115P Polymorphism NA 0.348 NA 14 0.114 A2RRH5 L133P Polymorphism 0.526 0.110 0.28 -27 0.055 A2RRH5 P470L Polymorphism NA 0.303 0.01 21 0.483 A2RRH5 R437H Polymorphism NA 0.036 0.13 -3 0.037 A2RRH5 V393L Polymorphism NA 0.041 0.04 -21 0.069 A2RRP1 I243V Polymorphism NA 0.204 NA -23 0.154 A2RRP1 R1004Q Polymorphism NA 0.278 NA 34 0.295 A2RRP1 S1178N Polymorphism NA 0.152 NA 23 0.294 A2RTY3 S480F Polymorphism NA 0.046 NA -32 0.008 A2RU48 C49R Polymorphism NA 0.767 NA 61 0.811 A2RU48 K75R Polymorphism NA 0.068 NA 11 0.056 A2RUB6 Q383R Polymorphism NA 0.082 0.00 -12 0.075 A2RUB6 R460Q Polymorphism NA 0.225 0.07 25 0.343 A2RUC4 S50G Polymorphism NA 0.376 0.38 2 0.393 A2RUQ5 R155K Polymorphism NA 0.268 NA 7 0.070 A2RUS2 S143N Polymorphism 0.094 0.307 0.14 -10 0.223 A2RUU4 F15S Polymorphism 0.163 0.554 0.09 10 0.311 A2VDJ0 M645T Polymorphism 0.238 0.116 0.11 -3 0.198 A2VEC9 Q146R Polymorphism NA 0.068 0.45 -5 0.044 A2VEC9 V298M Polymorphism NA 0.487 0.16 -24 0.289 A2VEC9 V539M Polymorphism NA 0.106 0.15 -11 0.213 A2VEC9 C3892W Polymorphism NA 0.757 0.00 73 0.894 A2VEC9 H4164R Polymorphism NA 0.089 0.74 19 0.120 A2VEC9 L1273P Polymorphism NA 0.756 0.01 42 0.616 A2VEC9 L2891V Polymorphism NA 0.161 0.45 -26 0.127 A2VEC9 N3512S Polymorphism 0.167 0.068 0.73 -12 0.075 A2VEC9 P1448Q Polymorphism NA 0.249 0.99 12 0.327 A2VEC9 R3909C Polymorphism NA 0.920 0.20 62 0.821 A2VEC9 R4330C Polymorphism NA 0.951 0.00 70 0.939 A2VEC9 S1272P Polymorphism NA 0.240 1.00 -25 0.186 A2VEC9 S1424G Polymorphism NA 0.328 0.35 -3 0.254 A2VEC9 S4028I Polymorphism NA 0.107 0.01 49 0.203 A2VEC9 T2017M Polymorphism NA 0.050 0.12 6 0.038 A3KMH1 M383T Polymorphism 0.085 0.038 0.00 -6 0.040 A3KMH1 R165H Polymorphism NA 0.809 0.00 36 0.777 A3KMH1 E1300K Polymorphism 0.074 0.273 NA 15 0.134 A4D0S4 M44T Polymorphism 0.208 0.449 1.00 15 0.047 A4D0S4 H234Y Polymorphism 0.229 0.769 0.22 3 0.412 A4D0S4 R1612S Polymorphism 0.243 0.478 0.29 -5 0.274 A4D0V7 I326T Polymorphism NA 0.087 NA -6 0.050 A4D0V7 K949T Polymorphism NA 0.069 NA 10 0.062 A4D161 Y20H Polymorphism NA 0.786 0.06 58 0.872 A4D161 S240G Polymorphism NA 0.071 0.07 28 0.047 A4D1B5 G305E Polymorphism 0.416 0.155 NA 5 0.027 A4D1B5 W653L Polymorphism NA 0.678 NA 46 0.401 A4D1E1 C248Y Polymorphism 0.667 0.118 0.05 36 0.129 A4D1E1 F634I Polymorphism 0.216 0.101 NA 16 0.024 A4D1E1 V1195I Polymorphism NA 0.068 0.24 15 0.075 A4D1E9 C88W Polymorphism 0.331 0.828 0.01 39 0.677 A4D1E9 L164F Polymorphism 0.729 0.470 0.09 20 0.579 A4D1E9 M368I Polymorphism NA 0.081 1.00 -15 0.022 A4D1E9 N110S Polymorphism 0.296 0.245 0.76 -29 0.176 A4D1S0 G339A Polymorphism 0.081 0.062 0.81 15 0.035 A4D256 I296L Polymorphism 0.683 0.837 0.14 5 0.744 A4D256 P238S Polymorphism NA 0.642 0.30 23 0.460 A4D2B0 H114N Polymorphism 0.312 0.874 0.00 79 0.915 A4D2G3 A209P Polymorphism 0.941 0.549 1.00 -18 0.348 A4FU01 M159V Polymorphism 0.189 0.148 0.53 -2 0.190 A4FU69 L237V Polymorphism NA 0.022 NA -43 0.019 A4FU69 R1274T Polymorphism NA 0.109 NA 43 0.117 A4FU69 V1252A Polymorphism NA 0.057 NA -13 0.069 A4QMS7 E87K Polymorphism NA 0.181 NA 16 0.146 A4QPB2 T61M Polymorphism 0.634 0.235 0.00 12 0.442 A4QPH2 E223Q Polymorphism 0.556 0.564 0.04 15 0.565 A4UGR9 P450A Polymorphism 0.423 0.244 0.14 45 0.296 A4UGR9 Y457H Polymorphism 0.465 0.140 0.50 -1 0.069 A4UGR9 A2910T Polymorphism NA 0.166 0.45 31 0.049 A4UGR9 G2728D Polymorphism NA 0.183 1.00 -7 0.054 A4UGR9 G3202E Polymorphism NA 0.603 0.00 10 0.402 A4UGR9 H2595Y Polymorphism NA 0.024 1.00 23 0.033 A4UGR9 L2423R Polymorphism NA 0.406 0.06 36 0.308 A4UGR9 N1833S Polymorphism NA 0.039 0.93 1 0.027 A4UGR9 R1626H Polymorphism 0.639 0.354 0.02 30 0.509 A4UGR9 S2553N Polymorphism NA 0.109 0.03 26 0.047 A4UGR9 Y2975C Polymorphism NA 0.055 0.28 -12 0.004 A5D8V6 S261A Polymorphism 0.218 0.207 0.67 -15 0.216 A5D8V6 V182D Polymorphism 0.289 0.250 0.03 27 0.361 A5D8W1 S22R Polymorphism NA 0.144 NA 30 0.105 A5D8W1 P459L Polymorphism NA 0.181 NA 12 0.160 A5D8W1 R306C Polymorphism NA 0.776 NA 51 0.688 A5PLK6 E5D Polymorphism NA 0.085 NA 5 0.068 A5PLL7 W7G Polymorphism NA 0.129 0.77 1 0.025 A5PLN7 K437E Polymorphism NA 0.463 0.03 42 0.333 A5PLN7 L748V Polymorphism NA 0.179 NA 16 0.171 A5PLN7 P532L Polymorphism NA 0.244 0.13 37 0.283 A5YKK6 D603A Polymorphism 0.169 0.433 0.00 4 0.379 A5YM72 P14T Polymorphism NA 0.190 NA 10 0.186 A6BM72 L474P Polymorphism 0.643 0.682 0.29 -2 0.369 A6BM72 L861F Polymorphism 0.139 0.524 0.09 33 0.252 A6H8M9 R5K Polymorphism NA 0.195 0.97 -50 0.188 A6H8Y1 N26S Polymorphism NA 0.088 NA 0 0.106 A6H8Y1 A125V Polymorphism 0.262 0.066 0.01 7 0.086 A6H8Y1 F1244I Polymorphism 0.097 0.049 0.16 3 0.025 A6H8Y1 G1180S Polymorphism 0.415 0.042 0.39 -1 0.024 A6H8Y1 K1469E Polymorphism NA 0.097 NA 6 0.091 A6H8Y1 N2555S Polymorphism NA 0.050 NA 12 0.061 A6H8Y1 Q1676E Polymorphism NA 0.095 NA -17 0.085 A6NC51 L199F Polymorphism 0.301 0.049 1.00 -22 0.021 A6NC98 D886A Polymorphism 0.162 0.133 0.69 -11 0.051 A6NCF5 E345G Polymorphism 0.927 0.404 0.36 48 0.660 A6NCF5 R176Q Polymorphism 0.642 0.192 0.65 25 0.366 A6NCI4 T464I Polymorphism NA 0.303 0.00 26 0.480 A6NCI4 Q1165P Polymorphism NA 0.561 0.01 53 0.729 A6NCV1 R2G Polymorphism 0.376 0.576 0.24 -38 0.467 A6ND48 V36A Polymorphism 0.217 0.243 0.13 -53 0.082 A6ND48 S170N Polymorphism 0.203 0.123 1.00 -11 0.108 A6NDA9 T510P Polymorphism NA 0.061 0.17 -33 0.015 A6NDA9 V496A Polymorphism NA 0.079 0.14 -3 0.065 A6NDB9 A440T Polymorphism NA 0.053 0.23 13 0.042 A6NDH6 S148T Polymorphism 0.205 0.445 0.26 -6 0.299 A6NDH6 T167S Polymorphism 0.228 0.121 0.98 -16 0.120 A6NDH6 V108I Polymorphism 0.235 0.267 0.79 -16 0.265 A6NDI0 L398M Polymorphism 0.070 0.311 0.23 12 0.253 A6NDN3 R200W Polymorphism NA 0.093 0.01 25 0.186 A6NE01 H2166Y Polymorphism NA 0.135 1.00 4 0.055 A6NE01 H2228Q Polymorphism NA 0.036 0.77 -39 0.056 A6NE01 M2193I Polymorphism NA 0.146 0.13 19 0.135 A6NE01 Q2316E Polymorphism NA 0.345 0.00 33 0.435 A6NE01 R1204G Polymorphism NA 0.109 0.34 36 0.073 A6NE52 H427Q Polymorphism NA 0.146 0.01 46 0.169 A6NE52 R149G Polymorphism NA 0.163 0.00 32 0.042 A6NEL2 P377T Polymorphism NA 0.123 0.68 37 0.097 A6NEN9 R156H Polymorphism NA 0.194 NA 37 0.222 A6NER3 R13S Polymorphism NA 0.341 0.07 28 0.200 A6NES4 K519N Polymorphism NA 0.036 1.00 15 0.033 A6NES4 A1594T Polymorphism 0.455 0.049 0.61 27 0.168 A6NES4 F1578L Polymorphism 0.614 0.316 0.38 19 0.457 A6NES4 V1214M Polymorphism NA 0.077 0.14 16 0.125 A6NES4 V1402M Polymorphism 0.558 0.223 0.07 16 0.459 A6NES4 V1601I Polymorphism 0.638 0.037 0.22 7 0.096 A6NET4 G44D Polymorphism 0.502 0.927 0.00 53 0.907 A6NF34 P547R Polymorphism NA 0.255 NA 25 0.162 A6NF89 T190I Polymorphism 0.943 0.831 0.01 33 0.842 A6NFD8 L147V Polymorphism 0.726 0.140 0.07 30 0.292 A6NFK2 L181F Polymorphism NA 0.040 1.00 -13 0.043 A6NFN9 I306M Polymorphism NA 0.238 NA 41 0.142 A6NFR6 L56P Polymorphism NA 0.449 0.16 12 0.130 A6NFU8 E169Q Polymorphism 0.198 0.186 0.28 6 0.211 A6NFY7 G57R Disease NA 0.512 0.00 55 0.724 A6NFY7 R55P Disease NA 0.847 0.00 56 0.865 A6NGD5 Q259K Polymorphism 0.071 0.094 0.29 -5 0.080 A6NGE4 R549W Polymorphism 0.096 0.165 0.97 -28 0.071 A6NGE7 Q57P Polymorphism NA 0.378 0.27 8 0.231 A6NGG8 S13C Polymorphism NA 0.169 NA 26 0.145 A6NGG8 L792V Polymorphism NA 0.050 0.10 20 0.060 A6NGG8 P1254L Polymorphism 0.680 0.140 0.07 0 0.070 A6NGQ2 A18T Polymorphism NA 0.037 0.40 14 0.038 A6NGR9 H97Q Polymorphism NA 0.039 NA 9 0.040 A6NGR9 V132A Polymorphism NA 0.126 0.93 -4 0.064 A6NGY1 C12R Polymorphism NA 0.204 NA 24 0.174 A6NGY1 L210M Polymorphism NA 0.042 NA -6 0.049 A6NGY5 T20A Polymorphism 0.111 0.494 0.55 5 0.150 A6NGY5 D301Y Polymorphism 0.971 0.096 1.00 18 0.165 A6NGY5 H232R Polymorphism 0.161 0.408 0.73 -15 0.234 A6NGY5 S233F Polymorphism 0.727 0.820 0.01 45 0.899 A6NH00 G39S Polymorphism 0.285 0.781 0.21 19 0.481 A6NH00 A221S Polymorphism 0.212 0.128 0.41 -45 0.170 A6NH00 M197R Polymorphism 0.645 0.812 0.01 65 0.905 A6NH00 T179A Polymorphism 0.163 0.111 0.21 16 0.200 A6NHG9 Y189C Polymorphism 0.967 0.204 1.00 -21 0.143 A6NHL2 Q135H Polymorphism NA 0.438 0.03 -7 0.414 A6NHL2 R250W Polymorphism 0.996 0.961 0.00 65 0.956 A6NHR9 I960V Polymorphism NA 0.077 0.00 -31 0.081 A6NHR9 V708I Polymorphism NA 0.058 0.00 5 0.092 A6NI79 R197K Polymorphism NA 0.030 1.00 -51 0.017 A6NIM6 E508K Polymorphism 0.306 0.623 0.06 45 0.722 A6NIM6 H141Q Polymorphism NA 0.427 0.54 41 0.337 A6NIV6 K159E Polymorphism 0.318 0.264 1.00 -9 0.195 A6NJ78 N31K Polymorphism NA 0.094 1.00 -7 0.034 A6NJ78 I267F Polymorphism NA 0.522 0.47 -17 0.452 A6NJL1 P187S Polymorphism 0.458 0.311 0.17 5 0.280 A6NJL1 V208I Polymorphism 0.161 0.075 0.20 7 0.060 A6NJZ3 L13Q Polymorphism 0.700 0.876 0.00 38 0.730 A6NJZ3 T222A Polymorphism 0.711 0.285 0.46 4 0.488 A6NK53 S247P Polymorphism 0.596 0.491 0.08 41 0.715 A6NK97 A139V Polymorphism NA 0.225 0.20 0 0.319 A6NKB5 R117K Polymorphism NA 0.050 0.53 -38 0.070 A6NKC4 H175R Polymorphism 0.575 0.241 0.55 0 0.419 A6NKC4 P105L Polymorphism 0.981 0.067 1.00 -54 0.029 A6NKC9 M137T Polymorphism NA 0.171 0.44 -20 0.096 A6NKF1 L186P Polymorphism 0.714 0.978 0.01 65 0.941 A6NKF2 C335G Polymorphism NA 0.240 0.40 0 0.058 A6NKG5 E849Q Polymorphism 0.791 0.185 0.06 31 0.482 A6NKK0 I153L Polymorphism 0.072 0.344 1.00 -36 0.138 A6NKK0 S148T Polymorphism 0.205 0.459 0.28 -9 0.301 A6NKK0 S230T Polymorphism 0.780 0.762 0.08 36 0.656 A6NKK0 V150I Polymorphism 0.093 0.097 1.00 -34 0.136 A6NKQ9 P185S Polymorphism NA 0.052 0.05 0 0.043 A6NKW6 S5R Polymorphism NA 0.376 0.00 42 0.388 A6NKW6 A111P Polymorphism NA 0.149 0.09 41 0.044 A6NL05 R72K Polymorphism NA 0.046 1.00 -20 0.050 A6NLF2 P375L Polymorphism 0.942 0.081 1.00 -2 0.029 A6NLJ0 D346E Polymorphism NA 0.139 1.00 -36 0.039 A6NLJ0 F276V Polymorphism NA 0.369 0.35 7 0.453 A6NLP5 I78M Polymorphism 0.412 0.323 0.03 17 0.459 A6NM43 C217S Polymorphism 0.188 0.292 0.83 22 0.179 A6NM43 S395G Polymorphism 0.407 0.144 0.90 -7 0.114 A6NMB9 T366P Polymorphism NA 0.310 0.30 -3 0.263 A6NMN3 R69L Polymorphism NA 0.056 NA -21 0.029 A6NMS3 I206V Polymorphism 0.089 0.136 0.79 -23 0.115 A6NMU1 C277R Polymorphism NA 0.355 0.54 46 0.294 A6NMU1 Y180S Polymorphism 0.610 0.079 0.42 3 0.114 A6NMX2 D227Y Polymorphism 0.945 0.975 0.00 65 0.952 A6NMZ7 E461A Polymorphism 0.344 0.230 0.19 19 0.268 A6NMZ7 R1739Q Polymorphism NA 0.354 0.15 42 0.429 A6NNM8 A126T Polymorphism 0.186 0.144 0.28 43 0.265 A6NNM8 T262I Polymorphism 0.485 0.641 0.29 -44 0.301 A6NNN8 S220T Polymorphism 0.714 0.388 0.75 19 0.588 A6NNP5 K120R Polymorphism NA 0.023 NA -49 0.027 A6PVS8 A255T Polymorphism NA 0.062 1.00 -36 0.020 A6PVS8 E434K Polymorphism NA 0.249 0.00 17 0.151 A6PVS8 H156Y Polymorphism NA 0.166 0.05 7 0.136 A6PVS8 L483F Polymorphism NA 0.201 0.00 33 0.225 A6PVY3 I3S Polymorphism NA 0.188 NA -32 0.158 A6PVY3 Q143R Polymorphism NA 0.128 NA 33 0.029 A6PW82 H606R Polymorphism NA 0.046 NA -5 0.044 A6QL63 G448S Polymorphism NA 0.141 0.31 -2 0.102 A6QL63 A1002D Polymorphism 0.755 0.881 0.00 36 0.854 A6QL63 G1076S Polymorphism 0.398 0.084 0.19 -2 0.094 A7E2Y1 P738S Polymorphism 0.305 0.802 0.01 -14 0.510 A7E2Y1 V1875E Polymorphism NA 0.825 0.00 11 0.812 A7MBM2 C56S Polymorphism NA 0.352 0.02 19 0.259 A7MBM2 G1145S Polymorphism NA 0.117 0.40 -27 0.089 A7MBM2 R1247W Polymorphism NA 0.048 0.08 10 0.025 A7MD48 R406Q Polymorphism NA 0.079 0.41 20 0.042 A7MD48 R547S Polymorphism NA 0.235 0.58 39 0.081 A8K0R7 V693M Polymorphism NA 0.231 NA 36 0.147 A8K2U0 C970Y Polymorphism 0.887 0.965 0.03 69 0.944 A8K2U0 G207R Polymorphism NA 0.296 0.05 19 0.241 A8K2U0 T1131M Polymorphism 0.284 0.086 0.10 20 0.272 A8K2U0 T1412A Polymorphism 0.287 0.130 0.42 2 0.248 A8K7I4 K426R Polymorphism 0.421 0.156 0.59 9 0.150 A8K7I4 R152K Polymorphism 0.254 0.402 0.12 -13 0.271 A8K855 R375K Polymorphism NA 0.218 0.00 7 0.206 A8K855 T248I Polymorphism NA 0.339 0.01 34 0.282 A8K8P3 R549Q Polymorphism NA 0.066 0.56 11 0.095 A8MPS7 A263T Polymorphism NA 0.134 0.63 -6 0.200 A8MPX8 F123L Polymorphism NA 0.164 0.01 9 0.085 A8MT70 A473G Polymorphism NA 0.256 NA 9 0.153 A8MT70 A636G Polymorphism NA 0.127 NA 9 0.110 A8MT70 E555K Polymorphism NA 0.153 NA 2 0.074 A8MT70 I511T Polymorphism NA 0.304 NA 24 0.171 A8MTY7 S130N Polymorphism 0.717 0.203 0.11 32 0.225 A8MTZ7 I140V Polymorphism NA 0.065 0.73 -21 0.022 A8MV23 D143N Polymorphism NA 0.718 0.22 18 0.484 A8MV24 P61L Polymorphism NA 0.114 NA -8 0.110 A8MVA2 Y86C Polymorphism 0.992 0.184 1.00 6 0.127 A8MVW5 K86T Polymorphism 0.196 0.043 0.54 15 0.037 A8MWL7 R108C Polymorphism 0.572 0.201 0.08 47 0.390 A8MWS1 E258D Polymorphism 0.661 0.314 0.24 10 0.505 A8MWS1 K160T Polymorphism 0.497 0.218 0.57 -13 0.187 A8MWY0 L729V Polymorphism 0.052 0.036 1.00 -43 0.016 A8MWY0 N539Y Polymorphism 0.554 0.368 0.05 45 0.585 A8MXQ7 T509R Polymorphism NA 0.089 NA 23 0.031 A8MXY4 A150G Polymorphism 0.432 0.145 0.71 0 0.129 A8MYU2 D175N Polymorphism 0.474 0.704 0.03 45 0.650 A8MYU2 W768R Polymorphism 0.812 0.269 0.51 21 0.371 A8TX70 E455K Polymorphism 0.052 0.432 0.50 5 0.109 A8TX70 H805R Polymorphism NA 0.457 0.59 42 0.359 A8TX70 T1280P Polymorphism NA 0.447 0.28 36 0.550 A9YTQ3 D627H Polymorphism 0.079 0.056 0.06 3 0.036 A9YTQ3 L114P Polymorphism 0.456 0.583 0.06 29 0.502 A9Z1Z3 V1318I Polymorphism 0.401 0.282 0.19 12 0.343 B0I1T2 V49M Polymorphism 0.604 0.650 0.20 -3 0.514 B0I1T2 R798Q Polymorphism 0.302 0.443 0.44 -7 0.430 B0YJ81 E64K Polymorphism 0.136 0.056 0.67 -23 0.019 B0YJ81 E64Q Polymorphism 0.107 0.091 0.42 -21 0.046 B0YJ81 V70F Polymorphism 0.203 0.218 0.71 -39 0.212 B1AH88 H53R Polymorphism NA 0.208 NA 21 0.036 B1AK53 D744N Disease 0.646 0.197 0.00 44 0.436 B1AK53 R322H Polymorphism NA 0.339 0.03 -44 0.357 B1AK53 R774Q Disease 0.333 0.222 0.15 34 0.378 B1AK53 S719R Disease 0.534 0.245 0.04 42 0.554 B1AK53 Y323C Polymorphism NA 0.712 0.02 -16 0.308 B1AKI9 P193R Polymorphism NA 0.166 0.02 25 0.217 B1ANS9 R952W Polymorphism NA 0.395 NA 59 0.662 B1ANY3 W162R Polymorphism NA 0.092 0.86 6 0.036 B1APH4 P61R Polymorphism 0.119 0.713 0.00 37 0.286 B2RTY4 R85Q Polymorphism NA 0.458 0.02 46 0.605 B2RTY4 A825V Polymorphism NA 0.140 0.58 -37 0.123 B2RTY4 L211P Polymorphism 0.560 0.932 0.00 19 0.869 B2RTY4 R946Q Polymorphism 0.254 0.852 0.02 38 0.597 B2RTY4 T161I Polymorphism 0.244 0.229 0.02 1 0.291 B2RTY4 H1795Y Polymorphism 0.269 0.116 0.00 29 0.171 B2RTY4 R1834C Polymorphism 0.725 0.616 0.00 53 0.871 B2RTY4 S1362P Polymorphism NA 0.084 0.10 -11 0.051 B2RU33 A13T Polymorphism NA 0.075 0.03 29 0.069 B2RU33 C72Y Polymorphism NA 0.631 0.00 49 0.476 B2RU33 H30P Polymorphism NA 0.301 0.02 35 0.227 B2RU33 M166I Polymorphism 0.093 0.214 0.63 -57 0.034 B3GLJ2 T30K Polymorphism NA 0.369 0.40 31 0.218 O00115 H204R Polymorphism 0.189 0.183 0.67 -15 0.236 O00115 R314L Polymorphism 0.931 0.957 0.00 60 0.954 O00116 L469P Disease 0.660 0.770 0.34 63 0.890 O00116 R419H Disease 0.892 0.737 0.01 55 0.919 O00116 T309I Disease 0.451 0.643 0.11 56 0.738 O00141 A342V Polymorphism 0.233 0.509 0.07 13 0.395 O00141 V219I Polymorphism 0.097 0.053 1.00 -35 0.060 O00142 I53M Disease NA 0.368 0.01 39 0.605 O00142 T64M Disease 0.783 0.500 0.00 60 0.893 O00142 H121N Disease 0.739 0.371 0.30 54 0.603 O00142 I212N Disease 0.755 0.378 0.01 48 0.661 O00142 R183W Disease 0.816 0.935 0.01 33 0.874 O00142 R192K Disease 0.787 0.872 0.00 38 0.844 O00142 T108M Disease 0.662 0.575 0.08 27 0.756 O00151 N175S Polymorphism 0.198 0.056 0.84 -19 0.068 O00160 P960L Polymorphism 0.197 0.257 0.02 21 0.244 O00167 T238A Polymorphism NA 0.160 0.17 14 0.141 O00170 Q228K Polymorphism 0.151 0.102 0.97 -38 0.082 O00175 S31F Polymorphism 0.727 0.264 0.58 37 0.395 O00175 A102T Polymorphism 0.433 0.200 0.67 17 0.174 O00175 Q110E Polymorphism 0.413 0.283 0.41 7 0.162 O00178 G91R Polymorphism NA 0.928 0.00 41 0.870 O00182 G5S Polymorphism NA 0.108 0.98 -14 0.119 O00186 C546G Polymorphism 0.352 0.842 0.42 26 0.745 O00192 R909Q Polymorphism 0.237 0.165 0.29 12 0.141 O00192 R912W Polymorphism 0.508 0.138 0.04 39 0.170 O00192 V175A Polymorphism NA 0.043 0.64 5 0.035 O00194 A92T Polymorphism 0.655 0.695 0.11 10 0.670 O00203 L580R Disease 0.949 0.964 0.00 53 0.941 O00203 V585E Polymorphism 0.620 0.355 1.00 -34 0.447 O00204 V240I Polymorphism 0.100 0.482 1.00 -36 0.112 O00206 C246S Polymorphism NA 0.309 0.50 29 0.243 O00206 E474K Polymorphism 0.138 0.528 0.96 -21 0.128 O00206 K694R Polymorphism 0.314 0.126 0.54 24 0.260 O00206 S400N Polymorphism 0.150 0.174 0.84 -36 0.113 O00206 T175A Polymorphism 0.211 0.220 0.78 22 0.272 O00206 V310G Polymorphism NA 0.236 0.09 50 0.447 O00212 C134R Polymorphism 0.927 0.383 1.00 -26 0.003 O00217 P79L Disease 0.670 0.514 0.01 17 0.753 O00217 R102H Disease 0.683 0.710 0.00 -6 0.800 O00219 R173H Polymorphism 0.290 0.183 0.59 13 0.160 O00220 G11V Polymorphism NA 0.279 NA 31 0.057 O00220 H141R Polymorphism 0.040 0.120 0.32 46 0.176 O00220 N297H Polymorphism 0.156 0.253 0.16 41 0.323 O00220 P105R Polymorphism NA 0.160 0.17 61 0.184 O00221 H95Q Polymorphism NA 0.113 NA -26 0.068 O00221 V194A Polymorphism NA 0.093 0.45 37 0.027 O00222 F21C Polymorphism NA 0.756 0.01 11 0.507 O00222 F362Y Polymorphism 0.183 0.464 0.22 -2 0.258 O00222 L430F Polymorphism 0.572 0.663 0.05 7 0.524 O00222 R343Q Polymorphism 0.097 0.227 0.40 -17 0.146 O00222 S902I Polymorphism 0.063 0.476 0.01 43 0.554 O00232 V358A Polymorphism 0.572 0.731 0.01 37 0.665 O00233 T74I Polymorphism 0.301 0.500 0.26 -17 0.429 O00233 E197G Polymorphism 0.397 0.269 0.20 19 0.329 O00233 R134W Polymorphism 0.772 0.131 0.02 37 0.403 O00238 I200K Disease 0.329 0.718 0.00 36 0.623 O00238 R149W Polymorphism NA 0.906 0.23 29 0.755 O00238 R224H Polymorphism 0.363 0.453 0.19 -3 0.313 O00238 R371Q Polymorphism 0.275 0.215 0.18 4 0.292 O00238 R486Q Disease 0.813 0.353 0.09 15 0.615 O00238 R486W Disease 0.973 0.524 0.01 37 0.827 O00241 R23G Polymorphism 0.228 0.122 0.34 -27 0.044 O00241 R53H Polymorphism 0.167 0.245 0.18 5 0.221 O00254 L15S Polymorphism NA 0.143 0.58 -64 0.010 O00254 M177V Polymorphism 0.895 0.411 0.00 19 0.651 O00254 N250D Polymorphism 0.131 0.112 0.85 7 0.126 O00255 E26K Disease NA 0.366 NA 21 0.501 O00255 E45G Disease NA 0.813 NA 60 0.888 O00255 E45K Disease NA 0.942 NA 72 0.936 O00255 G42D Disease NA 0.933 NA 60 0.927 O00255 L22R Disease NA 0.920 NA 44 0.786 O00255 L39W Disease NA 0.525 NA 34 0.712 O00255 P12L Disease NA 0.830 NA 36 0.763 O00255 R98L Disease NA 0.282 NA 22 0.179 O00255 A165P Disease 0.732 0.813 NA 58 0.903 O00255 A165T Disease 0.548 0.482 NA 7 0.466 O00255 A169D Disease 0.621 0.664 NA 40 0.731 O00255 A181P Disease 0.732 0.881 NA 44 0.848 O00255 A247V Disease 0.609 0.484 NA 37 0.670 O00255 A289E Disease 0.592 0.242 NA 39 0.524 O00255 A314P Disease 0.732 0.754 NA 51 0.867 O00255 A330P Disease 0.631 0.768 NA 51 0.866 O00255 A342D Disease 0.737 0.837 NA 40 0.844 O00255 A342P Disease 0.732 0.815 NA 46 0.839 O00255 A347P Disease 0.732 0.841 NA 53 0.890 O00255 A373D Disease 0.737 0.786 NA 43 0.819 O00255 A390V Disease 0.222 0.030 NA 3 0.039 O00255 A416P Disease 0.712 0.730 NA 53 0.868 O00255 C170R Disease 0.847 0.943 NA 62 0.943 O00255 C246F Disease 0.764 0.279 NA 27 0.536 O00255 C246R Disease 0.756 0.392 NA 42 0.592 O00255 C246Y Disease 0.805 0.493 NA 29 0.695 O00255 C426Y Disease 0.868 0.934 NA 51 0.913 O00255 D158V Disease 0.544 0.836 NA 58 0.887 O00255 D177Y Disease 0.876 0.815 NA 56 0.920 O00255 D362H Disease 0.811 0.483 NA 42 0.712 O00255 D423H Disease 0.794 0.681 NA 68 0.910 O00255 D423N Disease 0.583 0.823 NA 61 0.893 O00255 E184D Disease 0.473 0.745 NA 50 0.825 O00255 E184K Disease 0.599 0.877 NA 65 0.906 O00255 E184Q Disease 0.650 0.775 NA 58 0.708 O00255 E260K Disease 0.599 0.571 NA 46 0.526 O00255 E364K Disease 0.599 0.584 NA 42 0.756 O00255 F144V Disease 0.392 0.500 NA 30 0.704 O00255 F452S Disease 0.743 0.908 NA 49 0.892 O00255 G110E Disease NA 0.243 NA 9 0.373 O00255 G161D Disease 0.795 0.810 NA 71 0.923 O00255 G230R Disease 0.845 0.736 NA 62 0.917 O00255 G286R Disease 0.845 0.546 NA 53 0.853 O00255 G310D Disease 0.418 0.332 NA 27 0.477 O00255 H139D Disease 0.712 0.855 NA 60 0.910 O00255 H139P Disease 0.828 0.852 NA 63 0.934 O00255 H139R Disease 0.695 0.845 NA 57 0.906 O00255 H139Y Disease 0.688 0.725 NA 50 0.873 O00255 H186R Disease 0.691 0.859 NA 48 0.859 O00255 H322R Disease 0.691 0.830 NA 66 0.908 O00255 H322Y Disease 0.684 0.790 NA 60 0.897 O00255 I353N Disease 0.631 0.881 NA 36 0.833 O00255 I377M Disease 0.617 0.378 NA 14 0.441 O00255 K135I Disease 0.797 0.713 NA 48 0.838 O00255 L173P Disease 0.861 0.962 NA 48 0.879 O00255 L228P Disease 0.793 0.881 NA 40 0.859 O00255 L264R Disease 0.813 0.806 NA 60 0.918 O00255 L269P Disease 0.861 0.745 NA 49 0.866 O00255 L272P Disease 0.861 0.842 NA 45 0.863 O00255 L291P Disease 0.861 0.759 NA 57 0.910 O00255 L419P Disease 0.849 0.894 NA 51 0.905 O00255 L449P Disease 0.765 0.690 NA 49 0.835 O00255 P282H Disease 0.903 0.716 NA 55 0.909 O00255 P325L Disease 0.821 0.899 NA 34 0.867 O00255 P325R Disease 0.831 0.839 NA 49 0.892 O00255 P378S Disease 0.724 0.660 NA 34 0.788 O00255 P545S Disease 0.216 0.093 NA -29 0.031 O00255 P549S Disease 0.594 0.159 NA -32 0.102 O00255 Q265P Disease 0.777 0.615 NA 54 0.854 O00255 R176Q Polymorphism 0.249 0.086 NA 28 0.095 O00255 R234L Disease 0.402 0.349 NA 1 0.234 O00255 R319P Disease 0.274 0.779 NA 46 0.744 O00255 R360W Disease 0.930 0.730 NA 48 0.860 O00255 R420P Disease 0.795 0.929 NA 61 0.931 O00255 R532C Disease 0.613 0.193 NA 16 0.287 O00255 S159I Disease 0.650 0.447 NA 29 0.599 O00255 S160F Disease 0.724 0.160 NA -1 0.100 O00255 S258P Disease 0.610 0.280 NA 49 0.539 O00255 S432R Disease 0.691 0.745 NA 43 0.797 O00255 S560N Disease 0.538 0.304 NA 36 0.427 O00255 S560R Disease 0.593 0.353 NA 31 0.431 O00255 T316P Disease 0.394 0.560 NA 44 0.709 O00255 T349R Disease 0.415 0.432 NA 29 0.514 O00255 V167F Disease 0.694 0.811 NA 52 0.884 O00255 V189E Disease 0.775 0.864 NA 58 0.605 O00255 V220M Disease 0.383 0.218 NA 33 0.391 O00255 V245F Disease 0.586 0.532 NA 49 0.746 O00255 W188R Disease 0.843 0.940 NA 63 0.943 O00255 W188S Disease 0.839 0.944 NA 52 0.751 O00255 W346R Disease 0.843 0.898 NA 57 0.931 O00255 W428S Disease 0.821 0.944 NA 54 0.925 O00255 W441C Disease 0.911 0.940 NA 58 0.939 O00255 W441R Disease 0.826 0.952 NA 64 0.942 O00255 Y358D Disease 0.831 0.904 NA 54 0.915 O00258 V110I Polymorphism NA 0.074 0.71 -31 0.056 O00270 H91R Polymorphism 0.078 0.144 0.97 33 0.094 O00292 P286L Polymorphism 0.618 0.456 0.16 22 0.520 O00294 T67R Polymorphism NA 0.098 0.85 -20 0.008 O00294 A245V Disease NA 0.126 0.23 7 0.107 O00294 A496T Disease 0.207 0.321 0.43 -33 0.269 O00294 F382S Disease 0.559 0.873 0.01 40 0.872 O00294 F491L Disease 0.870 0.906 0.00 50 0.926 O00294 I459K Disease 0.572 0.615 0.11 22 0.565 O00294 K261T Disease NA 0.064 0.14 -7 0.064 O00294 K489R Disease 0.822 0.790 0.00 38 0.859 O00294 R378H Disease 0.391 0.425 0.01 -15 0.446 O00294 R420P Disease 0.499 0.961 0.01 35 0.847 O00294 T454M Disease 0.389 0.185 0.11 -13 0.361 O00295 D251N Polymorphism NA 0.034 0.61 2 0.061 O00295 E245K Polymorphism NA 0.055 0.91 12 0.055 O00295 G122S Polymorphism NA 0.109 0.12 -26 0.035 O00303 W172L Polymorphism 0.976 0.953 0.06 48 0.938 O00305 C104F Disease 0.485 0.751 0.06 13 0.745 O00311 Q23P Polymorphism NA 0.065 0.27 -3 0.069 O00311 E209D Polymorphism 0.259 0.281 0.62 17 0.255 O00311 F162L Polymorphism 0.219 0.236 1.00 -32 0.226 O00311 K441R Polymorphism 0.298 0.110 0.72 34 0.136 O00311 S498A Polymorphism NA 0.103 0.74 5 0.109 O00322 S33A Polymorphism NA 0.063 1.00 -30 0.010 O00322 M257T Polymorphism 0.459 0.063 0.60 29 0.023 O00330 D370V Polymorphism 0.868 0.685 0.03 34 0.824 O00337 D521N Polymorphism 0.061 0.341 0.34 -7 0.217 O00337 Q237K Polymorphism 0.648 0.391 0.41 0 0.455 O00337 V189I Polymorphism 0.059 0.206 1.00 -56 0.121 O00339 G14A Polymorphism NA 0.373 NA -30 0.265 O00339 A599T Polymorphism NA 0.167 0.60 -1 0.150 O00358 A65V Disease 0.947 0.879 0.07 28 0.885 O00358 S57N Disease NA 0.777 0.04 37 0.820 O00391 A294S Polymorphism NA 0.158 0.18 -7 0.206 O00391 R605P Polymorphism 0.060 0.175 0.32 24 0.131 O00400 D171G Polymorphism 0.285 0.724 0.38 8 0.370 O00400 S113R Disease 0.921 0.940 0.01 55 0.946 O00409 Y337H Polymorphism NA 0.281 0.01 30 0.370 O00410 E549K Polymorphism 0.265 0.900 0.04 53 0.824 O00410 Y905C Polymorphism 0.658 0.342 0.17 41 0.597 O00411 E555A Polymorphism 0.212 0.128 0.59 -15 0.066 O00418 H23R Polymorphism 0.047 0.122 1.00 -16 0.081 O00418 P75A Polymorphism 0.531 0.147 0.00 -5 0.240 O00418 D609H Polymorphism 0.702 0.348 0.00 30 0.614 O00418 Q361R Polymorphism 0.330 0.021 0.84 -28 0.016 O00418 R433W Polymorphism 0.812 0.180 0.03 58 0.308 O00423 S556P Polymorphism 0.388 0.426 0.35 -12 0.183 O00429 S71T Polymorphism 0.232 0.261 0.81 -28 0.232 O00443 T1415A Polymorphism NA 0.333 0.02 29 0.426 O00444 A226T Polymorphism 0.216 0.363 0.02 20 0.355 O00444 N449D Polymorphism 0.063 0.065 0.00 38 0.109 O00444 R146H Polymorphism 0.349 0.125 0.04 7 0.217 O00445 E4D Polymorphism 0.141 0.108 0.56 -36 0.039 O00445 R111Q Polymorphism 0.388 0.294 0.15 -10 0.320 O00451 L462Q Polymorphism NA 0.239 0.01 1 0.178 O00462 T701M Polymorphism 0.194 0.328 0.18 8 0.290 O00462 V253I Polymorphism NA 0.128 0.62 -52 0.135 O00462 V253L Polymorphism NA 0.464 0.29 -29 0.335 O00463 L358V Polymorphism NA 0.081 0.28 -11 0.143 O00463 N186H Polymorphism 0.629 0.183 0.11 29 0.306 O00469 G601V Disease 0.902 0.913 0.00 29 0.903 O00469 R598H Disease 0.868 0.846 0.00 49 0.912 O00469 T608I Disease 0.800 0.875 0.00 38 0.874 O00476 A100T Polymorphism 0.158 0.764 0.12 35 0.355 O00481 P456T Polymorphism 0.346 0.197 0.03 26 0.351 O00481 S224N Polymorphism 0.295 0.122 1.00 27 0.100 O00488 R6Q Polymorphism 0.674 0.175 0.54 25 0.165 O00499 K35N Disease 0.907 0.760 0.15 34 0.891 O00499 D151N Disease 0.880 0.932 0.07 50 0.943 O00505 P291S Polymorphism 0.297 0.470 0.27 -5 0.239 O00506 Q64H Polymorphism 0.720 0.373 0.57 26 0.637 O00507 P1035S Polymorphism NA 0.196 0.07 -16 0.230 O00512 R782K Polymorphism 0.216 0.081 0.92 25 0.051 O00515 L243P Polymorphism 0.147 0.058 0.29 -30 0.019 O00515 P279Q Polymorphism 0.253 0.071 0.28 13 0.041 O00519 P129T Polymorphism 0.254 0.108 0.51 -23 0.224 O00522 F97S Disease 0.502 0.720 0.00 35 0.724 O00522 K569E Disease 0.335 0.130 0.03 53 0.127 O00526 A47S Polymorphism 0.280 0.086 0.00 -62 0.232 O00533 T287A Polymorphism 0.159 0.208 0.80 28 0.168 O00534 E205K Polymorphism 0.227 0.500 0.91 4 0.332 O00534 H759R Polymorphism 0.093 0.148 0.00 -2 0.149 O00534 R757C Polymorphism 0.675 0.100 0.02 28 0.240 O00541 T264S Polymorphism 0.139 0.095 1.00 -25 0.097 O00555 A21V Polymorphism NA 0.195 0.34 -8 0.315 O00555 C256R Disease NA 0.920 0.00 66 0.859 O00555 C287Y Disease 0.992 0.838 0.00 48 0.959 O00555 D715E Disease 0.942 0.757 0.02 26 0.814 O00555 E918D Polymorphism NA 0.152 0.55 -13 0.096 O00555 G293R Disease 0.988 0.753 0.01 25 0.873 O00555 H253Y Disease NA 0.321 0.07 31 0.383 O00555 R192Q Disease 0.813 0.470 0.02 45 0.653 O00555 R195K Disease 0.643 0.839 0.00 52 0.887 O00555 R583Q Disease 0.991 0.855 0.00 53 0.979 O00555 S218L Disease NA 0.576 0.00 33 0.535 O00555 T666M Disease 0.996 0.744 0.00 65 0.968 O00555 V714A Disease 0.976 0.819 0.00 14 0.893 O00555 E1756K Disease 0.975 0.864 0.00 62 0.972 O00555 F1490S Disease 0.469 0.694 0.00 30 0.800 O00555 G1105S Polymorphism NA 0.130 0.56 -24 0.102 O00555 G1482R Disease 0.854 0.670 0.04 47 0.853 O00555 H1736L Disease 0.896 0.615 0.01 63 0.905 O00555 I1810L Disease 0.875 0.915 0.00 12 0.782 O00555 K1335E Disease 0.712 0.258 0.07 25 0.520 O00555 P1173L Polymorphism NA 0.148 0.34 5 0.204 O00555 P2394S Polymorphism 0.065 0.111 0.70 20 0.057 O00555 R1346Q Disease 0.991 0.670 0.00 42 0.926 O00555 R1661H Disease 0.812 0.900 0.00 47 0.926 O00555 R1667W Disease 0.998 0.907 0.00 32 0.943 O00555 R2135C Disease 0.721 0.426 0.18 57 0.637 O00555 V1456L Disease 0.593 0.731 0.01 19 0.594 O00555 V1493I Disease 0.393 0.630 0.77 16 0.346 O00555 W1683R Disease 0.990 0.508 0.00 62 0.949 O00555 Y1384C Disease 0.954 0.320 0.08 23 0.539 O00560 P26T Polymorphism NA 0.412 0.00 16 0.278 O00566 D140N Polymorphism NA 0.122 0.74 -4 0.115 O00566 E634K Polymorphism 0.219 0.090 0.52 -7 0.127 O00567 I121V Polymorphism 0.505 0.437 0.07 -18 0.573 O00574 E3K Polymorphism NA 0.453 0.17 -6 0.436 O00587 R302C Polymorphism 0.763 0.474 0.00 47 0.735 O00590 A248V Polymorphism 0.460 0.606 0.23 12 0.466 O00591 F391L Polymorphism 0.224 0.342 0.68 18 0.339 O00592 T60R Polymorphism 0.422 0.463 0.31 55 0.313 O00592 P298A Polymorphism 0.381 0.056 1.00 5 0.063 O00592 V358I Polymorphism 0.147 0.030 1.00 -23 0.055 O00602 Y126H Polymorphism 0.145 0.588 0.56 3 0.150 O00622 R334W Polymorphism 0.802 0.327 0.00 42 0.575 O00623 R34S Disease 0.353 0.373 0.28 21 0.330 O00623 L245I Polymorphism 0.291 0.156 0.83 -44 0.129 O00625 V228A Polymorphism 0.322 0.518 0.16 23 0.493 O00628 T14P Disease 0.665 0.640 0.07 44 0.780 O00628 A218V Disease 0.524 0.527 0.20 40 0.716 O00628 G217R Disease 0.838 0.744 0.01 71 0.958 O00634 P425S Polymorphism 0.342 0.334 0.05 16 0.365 O00716 G344R Polymorphism 0.980 0.928 0.00 53 0.943 O00748 R34W Polymorphism 0.947 0.644 0.01 -14 0.813 O00748 R206H Polymorphism 0.708 0.718 0.46 -19 0.486 O00754 H72L Disease 0.997 0.939 0.00 75 0.958 O00754 A481S Polymorphism 0.262 0.179 0.71 -65 0.145 O00754 E402K Disease 0.511 0.759 0.36 33 0.581 O00754 G801D Disease 0.899 0.883 0.18 57 0.924 O00754 H200L Disease 0.955 0.959 0.26 59 0.986 O00754 L809P Disease 0.937 0.918 0.01 23 0.891 O00754 N413S Polymorphism 0.387 0.236 0.23 15 0.385 O00754 P356R Disease 0.928 0.862 0.07 65 0.931 O00754 R337Q Polymorphism 0.222 0.351 0.58 -28 0.176 O00754 R750W Disease 0.965 0.948 0.13 55 0.943 O00754 S453Y Disease 0.676 0.718 0.03 49 0.880 O00754 T312I Polymorphism 0.317 0.246 0.28 -51 0.147 O00754 T355P Disease 0.987 0.985 0.00 60 0.952 O00754 W714R Disease 0.882 0.711 0.24 57 0.896 O00755 A109T Disease 0.932 0.880 0.00 21 0.895 O00755 R292C Disease 0.997 0.940 0.00 60 0.948 O00763 I552V Polymorphism 0.143 0.016 1.00 -50 0.026 O14490 R816Q Polymorphism 0.177 0.318 0.05 -24 0.211 O14513 V1403A Polymorphism NA 0.076 0.06 2 0.054 O14521 D92Y Disease 0.978 0.872 0.00 63 0.974 O14521 G12S Polymorphism 0.151 0.175 0.83 -22 0.099 O14521 H50R Polymorphism 0.270 0.232 0.43 35 0.309 O14521 P81L Disease 0.454 0.887 0.07 -4 0.697 O14521 H102L Disease 0.812 0.944 0.00 61 0.945 O14521 L139P Disease 0.945 0.986 0.00 41 0.924 O14521 Y114C Disease 0.979 0.932 0.00 79 0.892 O14522 A29P Polymorphism NA 0.429 0.02 -5 0.434 O14522 M76V Polymorphism NA 0.310 0.51 18 0.258 O14523 R413W Polymorphism NA 0.172 NA 24 0.127 O14525 G1270R Polymorphism NA 0.595 0.00 38 0.721 O14530 Q38R Polymorphism 0.293 0.054 0.17 -38 0.091 O14543 H125Y Polymorphism 0.379 0.332 0.01 31 0.436 O14576 N582T Polymorphism 0.422 0.431 0.62 33 0.382 O14578 G7E Polymorphism NA 0.321 0.00 42 0.334 O14578 R9Q Polymorphism NA 0.193 0.00 22 0.104 O14579 S13C Polymorphism 0.391 0.179 0.03 26 0.254 O14579 T117I Polymorphism 0.176 0.264 0.17 9 0.206 O14581 A69S Polymorphism 0.227 0.396 0.24 -38 0.295 O14581 I46T Polymorphism 0.568 0.854 0.00 32 0.760 O14581 V37A Polymorphism 0.259 0.523 0.21 12 0.442 O14593 L195P Disease 0.757 0.161 0.07 25 0.301 O14593 Q251E Polymorphism NA 0.527 1.00 16 0.460 O14594 A70T Polymorphism 0.136 0.201 0.69 -26 0.169 O14594 A1254V Polymorphism 0.134 0.578 0.20 48 0.635 O14613 I191F Polymorphism 0.526 0.250 0.05 -18 0.542 O14617 I1072V Polymorphism 0.096 0.157 0.48 9 0.129 O14626 I283V Polymorphism 0.078 0.200 0.53 29 0.226 O14633 I51S Polymorphism NA 0.327 NA 10 0.076 O14638 N744H Polymorphism 0.908 0.747 0.09 2 0.851 O14638 S786N Polymorphism 0.815 0.557 0.03 17 0.723 O14639 P434T Polymorphism NA 0.325 0.37 3 0.455 O14654 L34F Polymorphism NA 0.089 0.00 25 0.091 O14656 D264H Polymorphism 0.918 0.929 0.02 57 0.948 O14657 A54T Polymorphism 0.227 0.080 0.49 -22 0.089 O14669 P22S Polymorphism NA 0.077 0.75 31 0.106 O14669 G116C Polymorphism 0.134 0.299 0.11 27 0.139 O14678 A304T Polymorphism 0.152 0.111 0.24 14 0.161 O14682 I256S Polymorphism 0.536 0.500 0.01 19 0.748 O14686 A476T Polymorphism NA 0.073 0.60 -2 0.064 O14730 R441Q Polymorphism 0.340 0.608 0.07 47 0.732 O14730 S447L Polymorphism 0.085 0.328 0.68 -14 0.186 O14732 A88T Polymorphism 0.367 0.253 0.49 -22 0.250 O14733 A195T Polymorphism 0.249 0.472 0.03 35 0.461 O14733 L259F Polymorphism 0.495 0.801 0.01 38 0.817 O14733 N118S Polymorphism 0.173 0.274 0.26 -13 0.153 O14735 R199C Polymorphism 0.408 0.259 0.04 3 0.359 O14745 E225K Disease 0.310 0.310 0.68 19 0.333 O14745 L110V Disease NA 0.265 0.28 -14 0.261 O14745 R153Q Disease 0.763 0.652 0.23 39 0.775 O14746 A279T Polymorphism NA 0.157 0.00 -11 0.088 O14746 H412Y Polymorphism 0.606 0.265 0.18 30 0.436 O14746 K902N Disease 0.897 0.892 0.00 59 0.941 O14746 S948R Polymorphism 0.139 0.163 0.64 48 0.136 O14757 E223V Polymorphism 0.634 0.082 0.28 9 0.148 O14763 P32L Polymorphism NA 0.092 1.00 -64 0.041 O14764 E177A Disease 0.362 0.079 0.29 2 0.148 O14764 R220C Polymorphism 0.767 0.833 0.04 28 0.793 O14773 G77R Disease 0.281 0.860 0.01 43 0.608 O14773 S62L Polymorphism 0.317 0.305 0.24 -29 0.320 O14773 A454E Disease 0.733 0.931 0.01 67 0.942 O14773 C365R Disease 0.119 0.888 0.18 42 0.622 O14773 C365Y Disease 0.399 0.847 0.12 53 0.872 O14773 E343K Disease 0.260 0.538 0.25 38 0.662 O14773 F481C Disease 0.788 0.715 0.00 35 0.831 O14773 G284V Disease 0.323 0.612 0.06 14 0.513 O14773 G389E Disease 0.923 0.851 0.02 70 0.935 O14773 G473R Disease 0.941 0.854 0.00 84 0.939 O14773 G482R Disease 0.679 0.690 0.04 47 0.839 O14773 I287N Disease 0.316 0.443 0.03 6 0.497 O14773 K428N Disease 0.289 0.262 0.49 6 0.203 O14773 N286S Disease 0.198 0.242 0.29 14 0.295 O14773 Q278P Disease 0.271 0.936 0.01 19 0.747 O14773 Q422H Disease 0.675 0.841 0.00 64 0.919 O14773 R127Q Disease 0.400 0.143 0.60 -48 0.206 O14773 R206C Disease 0.715 0.881 0.15 18 0.862 O14773 R206H Disease 0.457 0.649 0.35 38 0.586 O14773 R447H Disease 0.369 0.843 0.03 70 0.905 O14773 S153P Disease 0.433 0.814 0.15 -20 0.655 O14773 S475L Disease 0.876 0.909 0.00 69 0.942 O14773 T353P Disease 0.722 0.785 0.01 45 0.871 O14773 V277M Disease 0.516 0.395 0.08 -33 0.588 O14773 V385D Disease 0.939 0.847 0.00 63 0.938 O14777 S66A Polymorphism 0.156 0.249 0.36 -25 0.181 O14777 A605P Polymorphism 0.400 0.098 0.27 28 0.097 O14786 F561L Polymorphism 0.261 0.711 0.15 28 0.502 O14786 V733I Polymorphism 0.118 0.116 0.94 -8 0.099 O14788 M199K Disease 0.499 0.694 0.00 67 0.876 O14791 R255K Polymorphism 0.097 0.028 1.00 -54 0.025 O14792 K295R Polymorphism 0.313 0.640 0.40 -18 0.424 O14793 I348T Polymorphism 0.607 0.722 0.00 30 0.607 O14793 K153R Polymorphism 0.231 0.081 0.65 -25 0.116 O14793 R371G Polymorphism NA 0.615 0.30 23 0.365 O14796 I36T Polymorphism 0.349 0.459 0.61 -11 0.490 O14796 N122K Polymorphism NA 0.244 0.03 19 0.182 O14802 K713N Polymorphism 0.689 0.858 0.03 14 0.840 O14802 R582L Polymorphism 0.394 0.258 0.28 24 0.238 O14804 R330C Polymorphism 0.667 0.798 0.02 54 0.769 O14813 A72V Disease 0.342 0.243 0.37 -1 0.337 O14815 A102V Polymorphism 0.862 0.941 0.11 32 0.891 O14815 A239T Polymorphism 0.240 0.533 0.66 -11 0.304 O14815 K322Q Polymorphism 0.115 0.403 0.65 -32 0.156 O14815 M611I Polymorphism 0.254 0.226 0.49 0 0.312 O14815 R277W Polymorphism 0.893 0.906 0.00 42 0.900 O14815 R458W Polymorphism 0.893 0.913 0.00 64 0.939 O14827 L713W Polymorphism NA 0.202 0.05 31 0.285 O14830 S120R Polymorphism NA 0.336 0.07 36 0.494 O14830 S575C Polymorphism 0.528 0.127 0.03 2 0.326 O14832 N83Y Disease 0.442 0.113 0.04 20 0.273 O14832 P29S Disease 0.154 0.304 0.79 -7 0.186 O14832 D177G Disease 0.698 0.943 0.02 75 0.939 O14832 E197Q Disease 0.469 0.664 0.11 41 0.674 O14832 F257S Disease 0.630 0.985 0.01 44 0.870 O14832 G204S Disease 0.724 0.972 0.00 62 0.932 O14832 H175R Disease 0.726 0.969 0.02 76 0.938 O14832 H220Y Disease 0.676 0.890 0.26 59 0.872 O14832 I199F Disease 0.566 0.719 0.05 50 0.843 O14832 N269H Disease 0.825 0.918 0.00 66 0.953 O14832 P173S Disease 0.452 0.680 0.72 39 0.548 O14832 Q176K Disease 0.544 0.902 0.06 64 0.905 O14832 R245Q Disease 0.411 0.273 0.16 32 0.341 O14832 R275Q Disease 0.680 0.891 0.00 73 0.908 O14832 R275W Disease 0.938 0.943 0.00 77 0.957 O14832 W193R Disease 0.863 0.981 0.14 77 0.949 O14836 A181G Disease NA 0.433 NA -34 0.493 O14836 C104R Disease NA 0.702 NA 72 0.875 O14836 P251L Polymorphism NA 0.091 NA 5 0.064 O14836 R202H Disease NA 0.064 NA 27 0.080 O14841 S284R Polymorphism 0.224 0.342 0.82 -27 0.135 O14880 G15C Polymorphism 0.615 0.491 0.04 -39 0.670 O14896 A2V Disease NA 0.084 0.00 0 0.153 O14896 R6C Disease 0.949 0.460 0.00 44 0.676 O14896 A16V Disease 0.336 0.355 0.22 33 0.490 O14896 A61G Disease 0.715 0.905 0.00 42 0.866 O14896 D98H Disease 0.899 0.855 0.00 61 0.938 O14896 G70R Disease 0.922 0.872 0.01 58 0.940 O14896 K66T Disease 0.817 0.898 0.03 56 0.930 O14896 K89E Disease 0.962 0.611 0.03 64 0.923 O14896 L22P Disease 0.472 0.809 0.13 21 0.808 O14896 N88H Disease 0.994 0.862 0.02 66 0.974 O14896 P39A Disease 0.994 0.825 0.00 59 0.950 O14896 P76S Disease 0.854 0.842 0.08 48 0.892 O14896 Q82K Disease 0.318 0.435 1.00 31 0.495 O14896 R45Q Disease 0.798 0.816 0.04 67 0.907 O14896 R84C Disease 0.997 0.907 0.00 71 0.959 O14896 R84G Disease 0.992 0.855 0.00 63 0.958 O14896 R84H Disease 0.996 0.771 0.00 66 0.953 O14896 S90G Disease 0.927 0.708 0.02 49 0.912 O14896 T64I Disease 0.825 0.515 0.04 44 0.799 O14896 V18A Disease 0.632 0.542 0.01 52 0.866 O14896 V18M Disease 0.758 0.704 0.01 59 0.902 O14896 W60G Disease 0.993 0.811 0.00 60 0.956 O14896 C347F Disease 0.706 0.406 0.05 13 0.600 O14896 C374W Disease 0.830 0.954 0.00 59 0.943 O14896 D430N Disease 0.721 0.480 0.63 25 0.550 O14896 E349V Disease 0.597 0.169 0.19 12 0.406 O14896 F369S Disease 0.262 0.706 0.30 4 0.404 O14896 G325E Disease 0.881 0.721 0.11 60 0.875 O14896 K320E Disease 0.719 0.648 0.05 38 0.802 O14896 K388E Disease 0.706 0.790 0.01 18 0.851 O14896 L251P Disease 0.913 0.966 0.00 54 0.940 O14896 L294P Disease 0.981 0.954 0.00 49 0.975 O14896 L345P Disease 0.751 0.944 0.01 19 0.861 O14896 P396S Disease 0.823 0.818 0.06 28 0.833 O14896 Q273R Disease 0.703 0.345 0.41 29 0.468 O14896 R250Q Disease 0.767 0.878 0.09 63 0.701 O14896 R339I Disease 0.898 0.677 0.00 22 0.826 O14896 R400W Disease 0.956 0.879 0.00 48 0.931 O14896 T100A Disease 0.290 0.343 0.18 42 0.400 O14896 V274I Polymorphism 0.400 0.473 0.00 6 0.434 O14896 V297I Disease 0.187 0.095 0.49 34 0.225 O14896 V321M Disease 0.777 0.847 0.01 45 0.873 O14901 Q62R Polymorphism NA 0.096 0.01 15 0.122 O14901 A347S Disease 0.095 0.301 0.12 -12 0.196 O14901 T220M Disease NA 0.172 0.04 34 0.180 O14920 Q369R Polymorphism 0.222 0.423 0.00 50 0.330 O14920 R554W Polymorphism 0.949 0.421 0.00 31 0.665 O14924 N1124S Polymorphism 0.116 0.078 NA 17 0.088 O14936 R28L Disease 0.362 0.362 0.32 -5 0.328 O14948 Q6H Polymorphism NA 0.130 0.04 26 0.148 O14948 G100S Polymorphism NA 0.537 0.75 -12 0.382 O14949 S45F Disease 0.367 0.500 0.07 31 0.684 O14950 E141G Polymorphism 0.484 0.842 0.12 30 0.693 O14958 R33Q Disease 0.702 0.846 0.23 31 0.854 O14958 D307H Disease 0.832 0.890 0.00 70 0.942 O14958 L167H Disease 0.702 0.670 0.00 46 0.816 O14965 F31I Polymorphism NA 0.081 0.42 20 0.061 O14965 G11R Polymorphism NA 0.056 0.34 32 0.047 O14965 P50L Polymorphism NA 0.197 0.16 37 0.236 O14965 V57I Polymorphism NA 0.081 0.18 17 0.072 O14967 A160S Polymorphism 0.313 0.189 1.00 -67 0.143 O14967 R352W Polymorphism 0.695 0.618 0.01 -33 0.726 O14967 V290I Polymorphism 0.555 0.168 0.14 -12 0.439 O14974 C116W Polymorphism 0.891 0.283 0.06 57 0.684 O14974 K734N Polymorphism 0.204 0.251 0.18 29 0.346 O14976 D787Y Polymorphism NA 0.145 0.04 0 0.157 O14976 S144L Polymorphism 0.425 0.347 0.02 -3 0.327 O14976 V580M Polymorphism 0.472 0.635 0.06 51 0.607 O14976 D1297N Polymorphism NA 0.345 0.00 21 0.275 O14976 S1168N Polymorphism 0.370 0.071 0.30 -7 0.082 O14978 C310S Polymorphism 0.105 0.438 0.46 11 0.245 O14983 P789L Disease 0.872 0.801 0.00 29 0.845 O15013 T357I Disease 0.286 0.296 0.00 18 0.283 O15013 V700I Polymorphism 0.163 0.070 0.26 -1 0.113 O15013 V725I Polymorphism 0.209 0.068 0.20 6 0.101 O15015 A98V Polymorphism NA 0.641 0.06 43 0.577 O15015 G921A Polymorphism NA 0.428 0.90 43 0.346 O15015 I774M Polymorphism NA 0.356 0.16 46 0.485 O15015 G1477D Polymorphism NA 0.603 0.02 48 0.664 O15015 R1249W Polymorphism 0.769 0.230 0.02 -1 0.520 O15018 A1649V Polymorphism NA 0.189 0.01 28 0.208 O15018 D1343E Polymorphism NA 0.130 0.73 10 0.114 O15018 Q1258K Polymorphism NA 0.079 0.04 32 0.088 O15018 R2247Q Polymorphism 0.154 0.090 0.07 23 0.052 O15020 L253P Disease 0.965 0.929 0.00 27 0.930 O15020 V1034A Polymorphism 0.400 0.220 0.57 -18 0.170 O15021 A77P Polymorphism NA 0.142 NA 28 0.016 O15021 P2201L Polymorphism NA 0.183 NA 29 0.171 O15027 R861C Polymorphism NA 0.086 0.00 40 0.125 O15034 P593R Polymorphism 0.446 0.500 0.06 5 0.501 O15040 A386T Polymorphism 0.279 0.052 0.00 12 0.100 O15040 I683V Polymorphism 0.119 0.025 NA -22 0.019 O15040 P439S Polymorphism 0.533 0.077 NA 21 0.091 O15040 V320I Polymorphism 0.066 0.048 0.07 8 0.083 O15047 D639N Polymorphism NA 0.228 0.34 19 0.145 O15050 P703L Polymorphism NA 0.070 NA -19 0.058 O15050 E1090G Polymorphism NA 0.177 NA 37 0.120 O15055 F949Y Polymorphism 0.306 0.143 1.00 37 0.136 O15055 S662G Disease 0.861 0.701 0.09 12 0.835 O15055 V729I Polymorphism 0.662 0.718 0.08 13 0.703 O15055 V903I Polymorphism 0.256 0.125 0.37 18 0.134 O15060 P689A Polymorphism NA 0.146 0.03 33 0.306 O15061 A272V Polymorphism 0.184 0.199 0.02 -14 0.222 O15061 G462S Polymorphism 0.104 0.056 0.00 7 0.100 O15061 P567L Polymorphism NA 0.097 0.00 -14 0.070 O15061 P761L Polymorphism NA 0.065 NA -26 0.081 O15061 Q976R Polymorphism NA 0.117 NA 22 0.122 O15061 R338W Polymorphism 0.740 0.312 0.00 42 0.598 O15061 R355W Polymorphism 0.081 0.192 0.00 43 0.294 O15061 R946W Polymorphism NA 0.132 NA 32 0.132 O15061 G1130S Polymorphism NA 0.129 NA 34 0.152 O15061 G1345A Polymorphism NA 0.025 NA -14 0.019 O15061 P1059L Polymorphism NA 0.161 NA 14 0.162 O15061 S1077L Polymorphism NA 0.168 NA 25 0.168 O15062 D300G Polymorphism NA 0.072 0.06 43 0.068 O15067 L621P Polymorphism 0.207 0.425 0.28 -38 0.324 O15069 D438E Polymorphism NA 0.080 NA -5 0.036 O15069 K591E Polymorphism NA 0.027 0.03 14 0.029 O15078 W7C Disease NA 0.657 0.00 41 0.742 O15078 K838E Polymorphism 0.137 0.100 0.37 -17 0.054 O15078 L906W Polymorphism 0.567 0.144 0.01 41 0.239 O15078 R1237H Polymorphism NA 0.182 0.06 -11 0.165 O15085 H1427R Polymorphism NA 0.296 0.03 57 0.114 O15111 S126C Polymorphism 0.623 0.202 0.06 -26 0.419 O15117 P51L Polymorphism 0.680 0.124 0.04 30 0.222 O15117 K332R Polymorphism 0.290 0.095 0.16 23 0.085 O15118 C63R Disease 0.645 0.963 0.00 49 0.901 O15118 C74Y Disease 0.979 0.972 0.00 65 0.959 O15118 Q92R Disease 0.313 0.179 0.60 22 0.265 O15118 A388P Disease 0.844 0.923 0.06 64 0.837 O15118 A521S Disease 0.393 0.241 0.04 -25 0.240 O15118 A605V Disease 0.667 0.621 0.09 56 0.792 O15118 A745E Disease 0.890 0.932 0.04 59 0.942 O15118 A767V Disease 0.884 0.910 0.02 31 0.832 O15118 A926T Disease 0.633 0.540 0.19 43 0.602 O15118 A927V Disease 0.335 0.377 0.53 23 0.348 O15118 C113R Disease 0.974 0.938 0.00 74 0.959 O15118 C177G Disease 0.227 0.742 0.75 13 0.373 O15118 C177Y Disease 0.965 0.882 0.07 61 0.944 O15118 C247Y Disease 0.866 0.781 0.09 55 0.917 O15118 C479Y Disease 0.949 0.976 0.00 76 0.944 O15118 C670W Disease 0.953 0.887 0.00 55 0.936 O15118 C956Y Disease 0.953 0.906 0.00 60 0.963 O15118 C976R Disease 0.945 0.903 0.21 57 0.935 O15118 D242H Disease 0.739 0.725 0.01 55 0.893 O15118 D242N Disease 0.615 0.787 0.02 46 0.794 O15118 D700N Disease 0.484 0.979 0.86 73 0.831 O15118 D874V Disease 0.571 0.571 0.22 38 0.782 O15118 D917Y Disease 0.711 0.678 0.42 14 0.755 O15118 D944N Disease 0.926 0.889 0.00 39 0.899 O15118 D945N Disease 0.525 0.862 0.42 37 0.774 O15118 D948H Disease 0.688 0.441 0.06 18 0.648 O15118 D948N Disease 0.534 0.514 0.15 23 0.513 O15118 D948Y Disease 0.778 0.641 0.03 9 0.760 O15118 E451K Disease 0.289 0.540 0.96 -6 0.275 O15118 E612D Disease 0.673 0.793 0.00 51 0.864 O15118 E742K Disease 0.641 0.898 0.62 67 0.879 O15118 F537L Disease 0.223 0.664 0.06 22 0.481 O15118 F703S Disease 0.896 0.931 0.00 56 0.945 O15118 F763L Disease 0.631 0.860 0.50 31 0.781 O15118 G248V Disease 0.542 0.134 0.50 -13 0.297 O15118 G333D Polymorphism 0.209 0.548 0.78 15 0.270 O15118 G640R Disease 0.651 0.946 0.00 58 0.807 O15118 G660S Disease 0.384 0.867 0.35 47 0.720 O15118 G673V Disease 0.977 0.949 0.00 58 0.954 O15118 G910S Disease 0.255 0.616 0.91 -29 0.352 O15118 G986S Disease 0.216 0.568 0.62 -17 0.328 O15118 G992A Disease 0.251 0.352 0.81 5 0.278 O15118 G992R Disease 0.437 0.642 0.55 31 0.758 O15118 G992W Disease 0.846 0.549 0.04 42 0.767 O15118 H510P Disease 0.389 0.859 0.16 43 0.767 O15118 H512R Disease 0.348 0.846 0.00 31 0.638 O15118 I858V Polymorphism 0.187 0.085 1.00 12 0.124 O15118 I943M Disease 0.712 0.442 0.04 9 0.614 O15118 K576R Disease 0.186 0.279 0.93 7 0.251 O15118 L380F Disease 0.795 0.814 0.11 64 0.889 O15118 L472P Polymorphism 0.804 0.941 0.02 -33 0.868 O15118 L684F Disease 0.761 0.814 0.15 38 0.849 O15118 L695V Disease 0.716 0.864 0.24 36 0.768 O15118 L724P Disease 0.898 0.883 0.00 48 0.922 O15118 L929P Disease 0.624 0.859 0.22 9 0.738 O15118 M272R Disease 0.491 0.728 0.35 41 0.793 O15118 M631R Disease 0.928 0.985 0.02 68 0.943 O15118 M642I Polymorphism 0.530 0.314 0.30 -46 0.291 O15118 M754K Disease 0.950 0.948 0.01 79 0.944 O15118 M996R Disease 0.235 0.545 0.37 34 0.340 O15118 N222S Disease 0.271 0.044 0.79 -51 0.103 O15118 N961S Disease 0.299 0.104 0.76 -6 0.150 O15118 N968S Disease 0.165 0.133 0.68 1 0.116 O15118 P166S Disease 0.379 0.535 0.43 14 0.410 O15118 P237S Disease 0.171 0.159 0.58 -27 0.180 O15118 P401T Disease 0.795 0.898 0.10 53 0.878 O15118 P433L Disease 0.489 0.378 0.91 -10 0.413 O15118 P434L Disease 0.143 0.123 0.89 6 0.100 O15118 P474L Disease 0.545 0.764 0.03 22 0.682 O15118 P543L Disease 0.836 0.767 0.02 34 0.777 O15118 P691L Disease 0.852 0.906 0.95 45 0.876 O15118 P888S Disease 0.948 0.869 0.00 52 0.937 O15118 Q775P Disease 0.886 0.973 0.16 57 0.944 O15118 Q862L Disease 0.953 0.419 0.00 48 0.727 O15118 Q928P Disease 0.586 0.901 0.21 -16 0.600 O15118 R372W Disease NA 0.625 0.07 45 0.753 O15118 R389C Disease 0.914 0.892 0.03 43 0.915 O15118 R404P Disease 0.968 0.983 0.00 60 0.951 O15118 R404Q Disease 0.939 0.940 0.00 67 0.949 O15118 R404W Disease 0.989 0.964 0.00 66 0.953 O15118 R518Q Disease 0.372 0.442 0.51 -4 0.233 O15118 R518W Disease 0.885 0.764 0.02 39 0.799 O15118 R615C Disease 0.898 0.595 0.04 45 0.847 O15118 R615L Disease 0.657 0.440 0.17 37 0.640 O15118 R789C Disease 0.959 0.940 0.00 71 0.980 O15118 R789G Disease 0.902 0.910 0.00 69 0.941 O15118 R934Q Disease 0.394 0.639 0.40 8 0.527 O15118 R958L Disease 0.527 0.691 0.02 -2 0.566 O15118 R958Q Disease 0.601 0.605 0.06 23 0.580 O15118 R978C Disease 0.861 0.491 0.05 20 0.690 O15118 S151G Polymorphism 0.600 0.342 0.34 14 0.491 O15118 S473P Disease 0.610 0.712 0.09 -44 0.503 O15118 S652W Disease 0.974 0.954 0.02 61 0.959 O15118 S666N Disease 0.535 0.721 0.45 1 0.721 O15118 S734I Disease 0.509 0.910 0.26 59 0.870 O15118 S849I Disease 0.868 0.854 0.03 43 0.882 O15118 S865L Disease 0.749 0.195 0.01 -16 0.467 O15118 S940L Disease 0.703 0.753 0.37 54 0.877 O15118 S954L Disease 0.739 0.366 0.03 -4 0.610 O15118 T137M Disease 0.394 0.137 0.10 27 0.298 O15118 T574K Disease 0.172 0.593 0.33 -10 0.219 O15118 V231G Disease 0.514 0.145 0.44 10 0.246 O15118 V378A Disease 0.523 0.412 0.02 16 0.586 O15118 V664M Disease 0.910 0.813 0.11 45 0.869 O15118 V727F Disease 0.727 0.683 0.03 41 0.802 O15118 V889M Disease 0.772 0.677 0.02 16 0.757 O15118 V950M Disease 0.271 0.128 0.32 -12 0.189 O15118 V959E Disease 0.617 0.233 0.01 2 0.558 O15118 V971G Polymorphism 0.461 0.500 0.19 28 0.458 O15118 W942C Disease 0.988 0.951 0.00 72 0.959 O15118 Y509S Disease 0.325 0.688 0.13 25 0.562 O15118 Y825C Disease 0.893 0.932 0.06 69 0.947 O15118 Y871C Disease 0.971 0.823 0.00 62 0.937 O15118 Y890C Disease 0.968 0.904 0.01 58 0.944 O15118 Y899D Disease 0.882 0.879 0.02 35 0.890 O15118 A1035V Disease 0.870 0.807 0.02 57 0.846 O15118 A1049V Polymorphism 0.337 0.275 0.31 14 0.292 O15118 A1054T Disease 0.769 0.754 0.00 23 0.768 O15118 A1062V Disease 0.828 0.666 0.03 0 0.771 O15118 A1174V Disease 0.779 0.817 0.15 38 0.832 O15118 A1216V Disease 0.864 0.857 0.00 27 0.793 O15118 C1168Y Disease 0.723 0.887 0.62 58 0.868 O15118 D1097N Disease 0.512 0.656 0.47 2 0.380 O15118 E1089K Disease 0.670 0.957 0.19 60 0.930 O15118 E1189G Disease 0.598 0.666 0.30 20 0.576 O15118 F1087L Disease 0.844 0.927 0.04 54 0.848 O15118 F1167L Disease 0.889 0.921 0.00 46 0.881 O15118 F1224L Disease 0.807 0.920 0.05 49 0.887 O15118 G1012D Disease 0.732 0.631 0.11 33 0.783 O15118 G1015V Disease 0.978 0.892 0.00 56 0.973 O15118 G1034R Disease 0.350 0.884 0.60 24 0.563 O15118 G1140V Disease 0.836 0.950 0.11 40 0.891 O15118 G1236E Disease 0.931 0.972 0.15 56 0.946 O15118 G1240R Disease 0.940 0.971 0.01 51 0.944 O15118 H1016R Disease 0.212 0.500 0.67 17 0.345 O15118 I1061T Disease 0.802 0.809 0.04 38 0.829 O15118 I1094T Disease 0.833 0.908 0.02 37 0.887 O15118 I1220T Polymorphism 0.851 0.881 0.02 51 0.904 O15118 L1213F Disease 0.892 0.924 0.00 48 0.920 O15118 L1213V Disease 0.862 0.894 0.00 47 0.892 O15118 M1142T Disease 0.895 0.959 0.00 52 0.940 O15118 N1137I Disease 0.839 0.569 0.02 22 0.771 O15118 N1150K Disease 0.949 0.883 0.00 54 0.940 O15118 N1156I Disease 0.956 0.738 0.00 4 0.808 O15118 N1156S Disease 0.830 0.716 0.00 25 0.800 O15118 P1007A Disease 0.689 0.688 0.00 48 0.743 O15118 R1059Q Disease 0.411 0.930 0.22 24 0.611 O15118 R1186H Disease 0.899 0.891 0.00 48 0.923 O15118 R1266Q Polymorphism 0.160 0.402 0.00 20 0.240 O15118 S1004L Disease 0.557 0.398 0.19 4 0.575 O15118 S1249G Disease 0.776 0.939 0.15 45 0.864 O15118 T1036K Disease 0.754 0.793 0.03 53 0.857 O15118 T1036M Disease 0.852 0.521 0.01 37 0.782 O15118 T1066N Disease 0.364 0.529 0.27 -5 0.464 O15118 T1205K Disease 0.932 0.938 0.02 57 0.948 O15118 T1205R Disease 0.936 0.945 0.01 60 0.949 O15118 V1023G Disease 0.890 0.739 0.01 52 0.886 O15118 V1165M Disease 0.881 0.923 0.01 58 0.940 O15118 V1212L Disease 0.610 0.795 0.32 13 0.569 O15118 Y1088C Disease 0.973 0.887 0.00 59 0.942 O15119 L143P Disease 0.913 0.940 0.00 19 0.907 O15119 Y149S Disease 0.997 0.876 0.00 64 0.950 O15120 A239V Disease 0.667 0.734 0.03 16 0.821 O15120 G136R Disease 0.590 0.751 0.08 25 0.625 O15120 L228P Disease 0.923 0.922 0.00 55 0.940 O15143 K37N Polymorphism 0.601 0.506 0.31 29 0.511 O15146 A27G Polymorphism NA 0.292 0.03 -12 0.408 O15146 L629F Polymorphism 0.497 0.720 0.00 24 0.652 O15146 M413I Polymorphism NA 0.163 0.36 52 0.143 O15146 N664S Polymorphism 0.403 0.135 0.49 0 0.269 O15146 P696L Polymorphism 0.392 0.522 0.23 -23 0.481 O15146 S159G Polymorphism 0.128 0.112 0.10 5 0.112 O15146 V644A Polymorphism 0.431 0.485 0.13 48 0.458 O15146 V829L Polymorphism 0.081 0.100 0.40 -31 0.075 O15151 I175T Polymorphism 0.266 0.166 0.64 -11 0.172 O15164 N796S Polymorphism 0.127 0.096 0.78 12 0.097 O15164 S762N Polymorphism 0.446 0.176 0.07 29 0.153 O15164 R1009S Polymorphism 0.138 0.301 0.14 21 0.225 O15169 G425S Disease 0.172 0.040 0.85 18 0.069 O15169 G650S Disease 0.156 0.086 0.31 9 0.096 O15169 L106R Disease 0.925 0.989 0.00 61 0.948 O15169 P345L Disease 0.934 0.574 0.00 35 0.800 O15178 E402K Polymorphism 0.074 0.166 0.32 39 0.153 O15178 G356S Polymorphism 0.087 0.124 0.98 -18 0.059 O15178 N369S Polymorphism 0.095 0.193 0.73 -8 0.131 O15182 V10L Polymorphism NA 0.140 0.14 -31 0.154 O15194 S121P Polymorphism NA 0.828 0.01 42 0.851 O15195 L740F Polymorphism 0.053 0.140 0.35 -15 0.055 O15204 M121T Polymorphism 0.232 0.281 0.67 -26 0.172 O15204 N444S Polymorphism 0.871 0.638 0.06 28 0.841 O15205 I68T Polymorphism 0.199 0.983 0.00 45 0.787 O15205 L51S Polymorphism 0.292 0.698 0.00 32 0.630 O15205 E120K Polymorphism 0.192 0.516 0.02 17 0.439 O15211 G705E Polymorphism 0.541 0.138 1.00 -15 0.069 O15213 S124Y Polymorphism 0.567 0.182 0.12 -30 0.304 O15213 V341A Polymorphism 0.600 0.912 0.07 43 0.867 O15217 L100P Polymorphism 0.352 0.500 0.27 41 0.671 O15218 C349R Polymorphism 0.168 0.164 0.52 37 0.139 O15228 D519G Disease 0.390 0.500 0.12 8 0.660 O15228 R211C Disease 0.970 0.948 0.00 73 0.959 O15228 R211H Disease 0.923 0.891 0.00 69 0.939 O15228 V495I Polymorphism 0.447 0.310 0.87 -26 0.253 O15228 Y586H Polymorphism 0.120 0.214 0.11 30 0.243 O15229 R452C Polymorphism 0.058 0.110 0.16 36 0.097 O15230 V889M Polymorphism NA 0.462 0.03 39 0.581 O15230 A1908T Polymorphism 0.271 0.148 0.46 43 0.241 O15230 H1717Y Polymorphism 0.296 0.242 0.22 59 0.353 O15230 M1258T Polymorphism NA 0.070 0.70 30 0.051 O15230 R1667W Polymorphism 0.570 0.398 0.03 56 0.584 O15230 R2053H Polymorphism 0.901 0.545 0.00 50 0.845 O15230 R2226H Polymorphism 0.568 0.066 0.57 50 0.198 O15232 P11S Polymorphism NA 0.153 0.37 1 0.117 O15232 R70H Disease 0.107 0.129 0.13 20 0.163 O15232 A128P Disease 0.725 0.650 0.12 10 0.811 O15232 A219D Disease 0.923 0.877 0.00 23 0.903 O15232 C304S Disease 0.883 0.865 0.04 65 0.975 O15232 E134K Disease 0.589 0.836 0.04 40 0.862 O15232 E252K Polymorphism 0.635 0.270 0.10 35 0.618 O15232 F105S Disease 0.941 0.746 0.00 32 0.903 O15232 I192N Disease 0.825 0.653 0.00 52 0.895 O15232 R121W Disease 0.981 0.830 0.00 47 0.944 O15232 T120M Disease 0.956 0.500 0.00 32 0.850 O15232 T195K Disease 0.915 0.879 0.00 45 0.909 O15232 V194D Disease 0.950 0.578 0.00 35 0.851 O15232 Y218N Disease 0.791 0.766 0.00 5 0.861 O15235 H8R Polymorphism NA 0.087 1.00 -4 0.025 O15239 G32R Polymorphism 0.709 0.718 0.00 42 0.665 O15244 P54S Polymorphism NA 0.515 0.02 -9 0.538 O15244 A297G Polymorphism 0.348 0.285 0.12 -24 0.372 O15244 K432Q Polymorphism 0.193 0.329 0.59 3 0.168 O15244 R463K Polymorphism 0.995 0.944 0.06 81 0.939 O15244 T201M Polymorphism 0.157 0.337 0.23 4 0.229 O15245 L85F Polymorphism 0.360 0.157 0.08 18 0.247 O15245 R61C Polymorphism NA 0.379 0.03 46 0.595 O15245 G401S Polymorphism 0.845 0.838 0.05 40 0.754 O15245 G465R Polymorphism 0.646 0.878 0.00 71 0.918 O15245 R342H Polymorphism 0.237 0.371 0.15 -3 0.228 O15245 R488M Polymorphism NA 0.529 0.29 4 0.284 O15245 V461I Polymorphism 0.124 0.161 0.92 -2 0.130 O15254 E34A Polymorphism NA 0.340 0.55 18 0.279 O15255 S152W Polymorphism NA 0.209 NA 26 0.043 O15259 G342R Disease 0.551 0.574 0.02 42 0.732 O15264 S41L Polymorphism 0.358 0.894 0.00 7 0.609 O15264 A282V Polymorphism NA 0.173 0.55 -45 0.096 O15264 A300T Polymorphism NA 0.387 0.26 -31 0.223 O15265 V862M Polymorphism 0.324 0.046 0.41 -12 0.055 O15266 L132V Disease 0.317 0.742 0.00 50 0.798 O15266 R153L Disease 0.550 0.921 0.10 44 0.870 O15266 R168W Disease 0.867 0.927 0.00 75 0.926 O15266 R173C Disease 0.822 0.940 0.00 66 0.933 O15269 C133W Disease 0.972 0.803 0.01 76 0.923 O15269 C133Y Disease 0.943 0.857 0.03 70 0.887 O15269 R151L Polymorphism 0.515 0.408 0.36 -4 0.509 O15269 V144D Disease 0.654 0.546 0.00 61 0.880 O15273 P90L Disease 0.572 0.483 NA 8 0.612 O15273 R70W Disease 0.828 0.296 NA 58 0.444 O15273 R87Q Disease 0.390 0.128 NA 40 0.130 O15273 E132Q Disease 0.167 0.063 NA 41 0.048 O15273 R106C Polymorphism 0.772 0.113 NA 47 0.244 O15273 R153H Disease 0.563 0.044 NA 38 0.046 O15273 T137I Disease 0.393 0.336 NA 32 0.176 O15287 L71P Disease NA 0.849 NA 46 0.829 O15287 G294E Polymorphism NA 0.571 NA 50 0.543 O15287 K430E Polymorphism NA 0.116 NA 26 0.055 O15287 P330S Polymorphism NA 0.097 NA 5 0.045 O15287 R513Q Polymorphism NA 0.052 NA 11 0.036 O15296 I676V Polymorphism 0.867 0.721 0.00 26 0.804 O15303 Q59P Polymorphism NA 0.170 0.35 19 0.209 O15303 E227V Polymorphism 0.323 0.610 0.00 34 0.592 O15303 E781K Disease 0.945 0.940 0.00 67 0.940 O15303 G150S Disease NA 0.894 0.00 10 0.817 O15303 M712V Polymorphism 0.348 0.359 1.00 -32 0.019 O15305 C9Y Disease 0.448 0.711 0.01 37 0.784 O15305 D65Y Disease 0.925 0.983 0.00 46 0.916 O15305 E93A Disease 0.621 0.852 0.02 26 0.854 O15305 F11C Disease 0.813 0.934 0.00 59 0.945 O15305 G15E Disease 0.855 0.888 0.01 46 0.787 O15305 L32R Disease 0.694 0.893 0.00 43 0.869 O15305 P20S Disease 0.215 0.371 0.04 -14 0.272 O15305 P69S Disease 0.133 0.114 1.00 -16 0.096 O15305 Q37H Disease 0.366 0.129 0.07 1 0.184 O15305 Q37L Polymorphism 0.314 0.270 0.17 -25 0.336 O15305 V44A Disease 0.620 0.810 0.00 54 0.893 O15305 V44L Disease 0.480 0.911 0.00 61 0.913 O15305 V67M Disease 0.418 0.551 0.04 39 0.758 O15305 Y64C Disease 0.756 0.569 0.00 33 0.743 O15305 Y76C Disease 0.873 0.813 0.02 59 0.923 O15305 A108V Disease 0.662 0.695 0.01 1 0.773 O15305 A233T Disease 0.133 0.271 0.33 -42 0.080 O15305 C103F Disease 0.490 0.694 0.02 29 0.784 O15305 C192G Disease 0.812 0.984 0.02 35 0.832 O15305 C241S Disease 0.466 0.600 0.03 20 0.582 O15305 D148N Disease 0.400 0.668 0.00 41 0.630 O15305 D185G Disease 0.186 0.555 0.36 -8 0.391 O15305 D188G Disease 0.777 0.983 0.02 44 0.873 O15305 D217E Disease 0.623 0.912 0.00 58 0.916 O15305 D223E Disease 0.353 0.873 0.09 32 0.738 O15305 D223N Disease 0.479 0.862 0.25 42 0.824 O15305 E139K Disease 0.297 0.686 0.06 8 0.445 O15305 E151G Disease 0.418 0.281 0.02 21 0.413 O15305 E197A Disease 0.219 0.866 0.20 -4 0.437 O15305 F119L Disease 0.638 0.945 0.00 43 0.867 O15305 F144L Disease 0.638 0.868 0.01 52 0.889 O15305 F157S Disease 0.708 0.849 0.01 26 0.864 O15305 F172V Disease 0.765 0.841 0.01 22 0.820 O15305 F183S Disease 0.854 0.979 0.00 45 0.895 O15305 F206S Disease 0.854 0.983 0.00 45 0.899 O15305 G117R Disease 0.917 0.939 0.00 56 0.946 O15305 G175R Disease 0.914 0.976 0.00 57 0.949 O15305 G176V Disease 0.727 0.971 0.00 54 0.917 O15305 G208A Disease 0.774 0.904 0.00 60 0.921 O15305 G214S Disease 0.805 0.920 0.00 53 0.920 O15305 G228C Disease 0.819 0.922 0.01 54 0.928 O15305 G228R Disease 0.791 0.939 0.00 68 0.944 O15305 H195R Disease 0.354 0.836 0.02 4 0.590 O15305 H218L Disease 0.316 0.624 0.08 16 0.630 O15305 I120T Disease 0.661 0.796 0.00 39 0.851 O15305 I132F Disease 0.733 0.913 0.01 55 0.917 O15305 I132N Disease 0.897 0.902 0.00 49 0.924 O15305 I132T Disease 0.706 0.890 0.04 44 0.869 O15305 I153T Disease 0.652 0.747 0.00 31 0.766 O15305 L104V Disease 0.626 0.810 0.00 41 0.847 O15305 M212V Polymorphism 0.164 0.308 0.43 -5 0.325 O15305 N101K Disease 0.394 0.922 0.19 0 0.540 O15305 N216I Disease 0.897 0.955 0.00 61 0.950 O15305 N216S Disease 0.722 0.919 0.00 58 0.921 O15305 P113L Disease 0.907 0.911 0.00 42 0.908 O15305 P131A Disease 0.819 0.878 0.00 42 0.844 O15305 Q177H Disease 0.664 0.868 0.00 51 0.890 O15305 R123Q Disease 0.784 0.955 0.00 46 0.891 O15305 R141C Disease 0.948 0.958 0.00 61 0.957 O15305 R141H Disease 0.877 0.925 0.00 54 0.907 O15305 R162W Disease 0.866 0.356 0.00 -5 0.627 O15305 R238G Disease 0.356 0.374 0.25 0 0.468 O15305 R238P Disease 0.435 0.653 0.24 21 0.735 O15305 T226S Disease 0.502 0.887 0.03 39 0.844 O15305 T237M Disease 0.895 0.943 0.03 40 0.899 O15305 T237R Disease 0.825 0.983 0.01 48 0.896 O15305 V129M Disease 0.630 0.657 0.01 51 0.811 O15305 V231M Disease 0.778 0.898 0.00 63 0.921 O15305 Y106C Disease 0.943 0.884 0.00 55 0.942 O15305 Y229S Disease 0.580 0.635 0.03 41 0.773 O15315 V9M Polymorphism NA 0.130 0.26 -33 0.182 O15315 P365R Polymorphism NA 0.177 0.03 6 0.146 O15315 S250A Polymorphism 0.160 0.424 0.82 1 0.314 O15315 V207L Polymorphism 0.135 0.395 0.99 -19 0.233 O15315 Y180C Polymorphism 0.097 0.677 0.18 60 0.237 O15320 E360Q Polymorphism 0.082 0.252 0.58 -4 0.181 O15320 G738R Polymorphism 0.122 0.101 0.69 0 0.039 O15320 I699V Polymorphism 0.069 0.082 0.75 -56 0.067 O15320 N375S Polymorphism 0.087 0.073 0.81 -11 0.112 O15327 Y311F Polymorphism 0.093 0.774 0.00 47 0.554 O15335 T350I Polymorphism 0.283 0.345 0.13 0 0.392 O15344 C266R Disease 0.650 0.710 0.28 59 0.894 O15344 I536T Disease 0.456 0.500 0.00 52 0.708 O15344 L295P Disease 0.742 0.920 0.01 54 0.919 O15344 L626P Disease 0.902 0.971 0.14 45 0.900 O15347 T51A Polymorphism 0.519 0.597 0.49 9 0.434 O15353 R69C Polymorphism NA 0.102 0.06 52 0.064 O15353 A283V Polymorphism 0.947 0.938 0.02 43 0.893 O15353 A599P Polymorphism NA 0.081 1.00 3 0.020 O15353 R411W Polymorphism 0.981 0.173 0.01 40 0.544 O15357 V721M Polymorphism 0.767 0.900 0.00 12 0.860 O15357 A1083G Polymorphism NA 0.103 0.57 -24 0.026 O15360 N8K Disease NA 0.059 NA 13 0.036 O15360 A181V Disease NA 0.214 NA -5 0.145 O15360 A277G Polymorphism NA 0.114 NA 5 0.081 O15360 A412V Polymorphism NA 0.071 NA 9 0.079 O15360 D252G Disease NA 0.179 NA 20 0.057 O15360 D598N Disease NA 0.381 NA 45 0.565 O15360 G501S Polymorphism NA 0.035 NA -29 0.019 O15360 H492R Disease NA 0.423 NA 68 0.691 O15360 L210R Disease NA 0.600 NA 50 0.676 O15360 L244F Disease NA 0.058 NA 18 0.089 O15360 L660P Disease NA 0.379 NA 43 0.542 O15360 L817P Disease NA 0.327 NA 41 0.463 O15360 L845P Disease NA 0.500 NA 53 0.683 O15360 P643A Polymorphism NA 0.044 NA 0 0.067 O15360 P739L Polymorphism NA 0.388 NA 26 0.532 O15360 Q869P Disease NA 0.489 NA 34 0.322 O15360 R435C Disease NA 0.637 NA 60 0.713 O15360 R951Q Polymorphism NA 0.341 NA 52 0.601 O15360 R951W Polymorphism NA 0.516 NA 56 0.690 O15360 S176F Polymorphism NA 0.202 NA 13 0.130 O15360 S858R Disease NA 0.057 NA 16 0.077 O15360 V761E Polymorphism NA 0.276 NA 41 0.380 O15360 Y843D Disease NA 0.604 NA 61 0.756 O15360 A1346T Disease NA 0.048 NA -34 0.056 O15360 D1359Y Disease NA 0.299 NA 39 0.420 O15360 F1262L Disease NA 0.295 NA 23 0.157 O15360 H1110P Disease NA 0.585 NA 63 0.802 O15360 H1417D Disease NA 0.091 NA 11 0.040 O15360 L1082P Disease NA 0.547 NA 54 0.680 O15360 L1249P Disease NA 0.362 NA 20 0.479 O15360 M1360I Disease NA 0.417 NA 35 0.478 O15360 P1324L Disease NA 0.222 NA 18 0.350 O15360 Q1128E Disease NA 0.202 NA 37 0.165 O15360 R1055L Disease NA 0.616 NA 55 0.667 O15360 R1055W Disease NA 0.671 NA 57 0.732 O15360 R1117G Disease NA 0.521 NA 33 0.691 O15360 R1400H Disease NA 0.273 NA 45 0.259 O15360 S1088F Disease NA 0.163 NA 43 0.170 O15360 T1131A Disease NA 0.476 NA 1 0.471 O15360 W1302R Disease NA 0.747 NA 54 0.833 O15374 A185T Polymorphism 0.133 0.114 0.37 31 0.154 O15379 N411S Polymorphism 0.172 0.401 0.61 -4 0.216 O15381 C359G Polymorphism 0.568 0.790 0.01 54 0.665 O15389 F322S Polymorphism 0.654 0.111 1.00 -16 0.071 O15392 E129K Polymorphism 0.156 0.021 1.00 -28 0.052 O15393 S254C Polymorphism 0.728 0.801 0.03 39 0.785 O15393 V160M Polymorphism 0.226 0.739 0.01 32 0.705 O15394 D347N Polymorphism NA 0.240 0.49 32 0.369 O15394 L350P Polymorphism 0.132 0.266 0.23 14 0.266 O15397 I6F Polymorphism NA 0.414 0.07 30 0.518 O15397 I640V Polymorphism 0.221 0.127 0.76 -16 0.127 O15403 E217D Polymorphism 0.187 0.410 0.13 -5 0.269 O15403 F204I Polymorphism 0.144 0.341 0.68 -46 0.153 O15403 I121T Polymorphism 0.469 0.811 0.25 -14 0.497 O15405 V128M Polymorphism NA 0.069 0.09 10 0.082 O15409 R553H Disease NA 0.931 0.00 79 0.934 O15417 A1193G Polymorphism 0.410 0.157 0.45 21 0.150 O15431 P25A Polymorphism NA 0.109 1.00 21 0.096 O15438 G11D Polymorphism NA 0.275 0.29 34 0.415 O15438 Q1365R Polymorphism 0.217 0.162 1.00 -29 0.080 O15439 L18I Polymorphism 0.223 0.194 0.38 -43 0.217 O15439 E757K Polymorphism 0.181 0.567 0.92 11 0.246 O15439 G187W Polymorphism 0.973 0.826 0.02 41 0.828 O15439 K304N Polymorphism 0.412 0.233 0.49 -20 0.272 O15439 M184T Polymorphism 0.298 0.245 0.57 -38 0.021 O15439 M744V Polymorphism NA 0.255 0.31 28 0.224 O15439 P403L Polymorphism 0.230 0.575 0.33 9 0.223 O15439 R820I Polymorphism 0.909 0.809 0.17 58 0.872 O15439 T356M Polymorphism 0.659 0.422 0.14 -9 0.538 O15439 V860M Polymorphism 0.714 0.514 0.16 -29 0.586 O15444 T23A Polymorphism 0.068 0.066 0.91 -49 0.032 O15444 T104M Polymorphism 0.111 0.081 0.17 35 0.025 O15446 Q504K Polymorphism NA 0.017 1.00 -29 0.020 O15446 T282A Polymorphism NA 0.048 0.26 7 0.033 O15453 Q102E Polymorphism NA 0.304 NA 35 0.098 O15455 P554S Disease NA 0.788 0.43 38 0.615 O15455 Y307D Polymorphism 0.580 0.406 0.07 23 0.545 O15457 A60V Polymorphism NA 0.097 0.01 32 0.131 O15457 A90T Polymorphism NA 0.090 0.13 14 0.092 O15457 S914N Polymorphism 0.283 0.161 0.19 -52 0.200 O15479 G318R Polymorphism NA 0.336 NA 24 0.479 O15480 R107H Polymorphism 0.101 0.273 0.55 -18 0.204 O15488 H7Y Polymorphism NA 0.270 NA -19 0.080 O15488 A270V Polymorphism NA 0.121 0.30 1 0.188 O15488 H313R Polymorphism 0.097 0.085 0.12 -3 0.087 O15503 A27T Polymorphism 0.064 0.101 0.55 -5 0.048 O15504 D391N Polymorphism 0.216 0.122 1.00 -10 0.063 O15504 K392N Polymorphism 0.141 0.135 0.16 31 0.115 O15516 E380K Polymorphism 0.485 0.936 0.05 33 0.797 O15520 C106F Disease 0.509 0.641 0.03 37 0.755 O15520 I156R Disease 0.794 0.506 0.00 61 0.893 O15522 D16A Polymorphism 0.128 0.121 0.09 26 0.200 O15527 A288V Polymorphism 0.396 0.376 0.99 10 0.400 O15527 D322N Polymorphism 0.382 0.410 0.10 23 0.384 O15527 R229Q Polymorphism 0.506 0.690 0.50 22 0.535 O15527 S320T Polymorphism 0.337 0.078 0.10 -36 0.118 O15527 S326C Polymorphism 0.242 0.135 0.20 27 0.288 O15528 V166L Polymorphism 0.276 0.246 0.19 -21 0.292 O15529 C45R Polymorphism 0.135 0.710 0.32 16 0.156 O15529 V227L Polymorphism 0.050 0.364 0.29 -24 0.217 O15529 V256A Polymorphism 0.055 0.173 0.72 -10 0.081 O15534 R968H Polymorphism 0.317 0.146 0.30 25 0.289 O15537 A98E Disease 0.284 0.829 0.06 54 0.868 O15537 C59S Disease 0.496 0.446 0.10 -41 0.431 O15537 E72D Disease 0.316 0.581 0.04 -2 0.451 O15537 E72K Disease 0.413 0.729 0.15 14 0.517 O15537 G70A Disease 0.476 0.750 0.02 30 0.789 O15537 G70S Disease 0.518 0.761 0.05 3 0.787 O15537 G74V Disease 0.689 0.825 0.03 35 0.852 O15537 L12H Disease NA 0.202 0.00 37 0.195 O15537 L13P Disease 0.090 0.242 0.00 35 0.200 O15537 W96R Disease 0.904 0.877 0.00 46 0.889 O15537 Y65C Disease NA 0.374 1.00 31 0.295 O15537 Y89C Disease 0.817 0.749 0.09 33 0.827 O15537 C110Y Disease 0.771 0.729 0.10 44 0.809 O15537 C142W Disease 0.892 0.436 0.05 34 0.319 O15537 C219G Disease 0.788 0.906 0.00 75 0.927 O15537 C219R Disease 0.897 0.937 0.00 83 0.931 O15537 C223R Disease NA 0.500 0.00 52 0.726 O15537 D143V Disease 0.684 0.280 0.13 29 0.577 O15537 D158N Polymorphism 0.150 0.400 0.05 19 0.266 O15537 E146D Disease 0.596 0.339 0.65 -1 0.478 O15537 E146K Disease 0.725 0.370 0.55 39 0.548 O15537 E215K Disease 0.705 0.576 0.00 63 0.884 O15537 E215Q Disease 0.745 0.525 0.00 55 0.866 O15537 F108C Disease 0.800 0.471 0.07 -5 0.615 O15537 G109E Disease 0.639 0.715 0.45 49 0.820 O15537 G109R Disease 0.717 0.769 0.44 51 0.731 O15537 G109W Disease 0.915 0.738 0.19 0 0.779 O15537 G135V Disease 0.895 0.421 0.01 41 0.680 O15537 G140E Disease 0.874 0.500 0.00 53 0.863 O15537 G140R Disease 0.904 0.493 0.00 55 0.865 O15537 G178D Disease 0.645 0.518 0.00 68 0.893 O15537 H207Q Disease 0.570 0.426 0.19 34 0.579 O15537 I136T Disease 0.485 0.430 0.00 9 0.393 O15537 I199T Disease 0.425 0.440 0.00 26 0.424 O15537 L103R Disease 0.880 0.556 0.00 35 0.831 O15537 L113F Disease 0.451 0.294 0.36 -16 0.348 O15537 L127P Disease 0.765 0.519 0.01 40 0.785 O15537 L216P Disease 0.901 0.472 0.00 35 0.714 O15537 P192R Disease 0.688 0.431 0.06 20 0.620 O15537 P192S Disease 0.546 0.307 0.08 1 0.603 O15537 P193L Disease 0.669 0.528 0.00 29 0.767 O15537 P193S Disease 0.546 0.421 0.00 29 0.498 O15537 P203L Disease 0.894 0.500 0.00 51 0.859 O15537 R102Q Disease 0.756 0.577 0.00 8 0.762 O15537 R102W Disease 0.956 0.615 0.00 44 0.852 O15537 R141C Disease 0.827 0.420 0.08 52 0.714 O15537 R141G Disease 0.582 0.459 0.43 44 0.591 O15537 R141H Disease 0.645 0.375 0.03 44 0.652 O15537 R182C Disease 0.827 0.358 0.19 44 0.654 O15537 R197C Disease 0.827 0.511 0.00 65 0.902 O15537 R197H Disease 0.645 0.493 0.00 60 0.868 O15537 R200C Disease 0.941 0.529 0.00 69 0.892 O15537 R200H Disease 0.862 0.513 0.00 70 0.898 O15537 R209H Disease 0.645 0.330 0.15 -4 0.563 O15537 R213W Disease 0.952 0.616 0.00 66 0.891 O15537 T138A Disease 0.186 0.500 0.00 58 0.628 O15537 W112C Disease 0.951 0.517 0.00 39 0.848 O15537 W163C Disease 0.847 0.491 0.00 69 0.908 O15537 Y155C Disease 0.935 0.465 0.01 67 0.825 O15540 T61M Polymorphism 0.724 0.343 0.05 8 0.630 O15550 T581A Polymorphism 0.198 0.140 0.00 0 0.278 O15550 T726K Polymorphism 0.090 0.081 0.00 20 0.187 O15553 R42W Disease NA 0.118 0.03 51 0.174 O15553 V33L Polymorphism NA 0.066 1.00 -4 0.041 O15553 A744S Disease 0.188 0.162 1.00 -16 0.040 O15553 D661N Disease 0.148 0.331 0.40 -31 0.233 O15553 E148Q Disease NA 0.111 0.00 23 0.203 O15553 E148V Disease NA 0.171 0.00 43 0.285 O15553 E163A Disease NA 0.044 0.01 28 0.074 O15553 E167D Disease NA 0.100 0.04 20 0.113 O15553 E230K Disease NA 0.266 0.08 0 0.160 O15553 E319K Disease 0.217 0.162 0.35 52 0.285 O15553 E474K Disease 0.217 0.408 0.21 4 0.318 O15553 E656A Disease 0.955 0.864 0.00 50 0.918 O15553 F479L Disease 0.145 0.249 0.32 -31 0.145 O15553 F743L Disease 0.681 0.859 0.00 58 0.686 O15553 G632S Disease 0.205 0.204 0.80 -29 0.121 O15553 G678E Disease 0.739 0.927 0.29 43 0.594 O15553 H478Y Disease 0.288 0.321 0.05 12 0.218 O15553 I591T Disease NA 0.353 0.74 44 0.269 O15553 I640M Disease 0.383 0.100 0.22 -8 0.228 O15553 I641F Disease 0.404 0.243 0.71 -23 0.183 O15553 I720M Disease 0.761 0.310 0.00 33 0.637 O15553 K695M Disease 0.645 0.427 0.10 33 0.635 O15553 K695R Disease 0.219 0.318 0.32 1 0.245 O15553 L110P Disease NA 0.126 0.24 14 0.103 O15553 L649P Disease 0.680 0.785 0.12 22 0.851 O15553 M680I Disease 0.199 0.104 0.50 -2 0.104 O15553 M680L Disease 0.122 0.319 0.75 24 0.142 O15553 M694I Disease NA 0.319 0.39 27 0.394 O15553 M694L Disease NA 0.331 0.66 21 0.185 O15553 M694V Disease NA 0.316 0.50 29 0.403 O15553 P369S Disease 0.302 0.386 0.09 -1 0.335 O15553 P646L Disease 0.559 0.273 0.17 10 0.493 O15553 P705S Disease 0.657 0.280 0.32 2 0.557 O15553 P758S Disease 0.437 0.611 0.05 28 0.572 O15553 P780T Disease NA 0.122 0.02 6 0.098 O15553 R408Q Disease 0.270 0.279 0.31 3 0.290 O15553 R653H Disease 0.201 0.074 1.00 -53 0.028 O15553 R761H Disease 0.201 0.122 0.38 -22 0.153 O15553 S108R Disease NA 0.056 0.00 32 0.102 O15553 S675N Disease 0.401 0.150 0.66 -24 0.121 O15553 T177I Disease NA 0.074 0.11 18 0.064 O15553 T267I Disease NA 0.095 0.02 30 0.114 O15553 T681I Disease 0.382 0.300 0.19 39 0.402 O15553 V704I Disease 0.092 0.063 0.39 11 0.079 O15553 V726A Disease 0.154 0.094 1.00 -33 0.037 O15553 Y688C Disease 0.752 0.794 0.03 39 0.683 O42043 C97Y Polymorphism 0.249 0.068 0.91 -11 0.010 O42043 V272I Polymorphism 0.099 0.343 0.07 50 0.142 O43147 R238K Polymorphism NA 0.181 0.00 11 0.242 O43149 V30A Polymorphism NA 0.130 NA 5 0.105 O43149 A2421T Polymorphism NA 0.163 NA 31 0.054 O43149 E2369Q Polymorphism NA 0.142 NA 11 0.123 O43149 I2014V Polymorphism NA 0.031 NA -25 0.005 O43149 L2303P Polymorphism NA 0.521 NA 53 0.702 O43149 S1437A Polymorphism NA 0.099 NA 34 0.072 O43156 A671V Polymorphism 0.389 0.699 0.05 46 0.777 O43156 A979T Polymorphism 0.215 0.231 0.00 39 0.272 O43156 R450H Polymorphism 0.184 0.163 0.12 44 0.201 O43157 R389W Polymorphism 0.606 0.746 0.04 53 0.858 O43167 A518T Polymorphism NA 0.155 0.05 1 0.207 O43175 A373T Disease 0.511 0.447 0.16 -3 0.517 O43175 G377S Disease 0.827 0.908 0.04 38 0.838 O43175 R135W Disease 0.723 0.905 0.00 59 0.908 O43175 V261M Disease 0.923 0.874 0.00 64 0.913 O43175 V425M Disease 0.444 0.401 0.07 -39 0.427 O43175 V490M Disease NA 0.654 0.01 18 0.729 O43181 T174P Polymorphism 0.592 0.273 0.00 21 0.542 O43182 D791E Polymorphism 0.181 0.183 0.03 -10 0.153 O43186 E80A Disease 0.299 0.869 0.00 45 0.746 O43186 R41Q Disease 0.847 0.778 0.00 57 0.848 O43186 R41W Disease 0.973 0.811 0.00 62 0.931 O43186 R90W Disease 0.973 0.867 0.00 78 0.931 O43186 A158T Polymorphism 0.294 0.172 0.73 -6 0.204 O43186 G122D Disease NA 0.126 0.34 9 0.193 O43186 V242M Disease 0.425 0.089 0.90 -43 0.093 O43187 I99V Polymorphism 0.080 0.118 1.00 -1 0.086 O43187 R43Q Polymorphism NA 0.485 0.00 60 0.456 O43187 S47Y Polymorphism NA 0.227 0.06 43 0.379 O43187 D431E Polymorphism NA 0.207 1.00 -32 0.147 O43187 D469N Polymorphism 0.057 0.414 0.47 -22 0.154 O43187 L392V Polymorphism 0.304 0.575 0.04 0 0.133 O43187 R147T Polymorphism NA 0.099 0.21 2 0.144 O43187 R214G Polymorphism 0.256 0.299 0.34 23 0.405 O43187 R566W Polymorphism 0.539 0.177 0.05 46 0.224 O43189 T42S Polymorphism 0.294 0.147 0.59 3 0.133 O43196 L85F Polymorphism NA 0.121 0.62 -5 0.127 O43196 L377F Polymorphism NA 0.930 0.00 -5 0.545 O43196 P786S Polymorphism 0.087 0.320 0.46 18 0.224 O43196 R351G Polymorphism NA 0.374 0.43 8 0.277 O43196 V206F Polymorphism NA 0.617 0.08 34 0.507 O43196 Y202C Polymorphism NA 0.703 0.05 23 0.667 O43246 T28I Polymorphism 0.366 0.079 0.19 11 0.180 O43248 P130S Polymorphism 0.109 0.168 0.91 -14 0.090 O43252 L270F Polymorphism 0.624 0.679 0.01 25 0.762 O43252 S587L Polymorphism NA 0.918 0.00 54 0.910 O43264 I77M Polymorphism 0.532 0.176 0.07 -12 0.202 O43278 P337L Polymorphism 0.425 0.142 0.24 -3 0.257 O43278 T142R Polymorphism NA 0.232 0.00 40 0.228 O43280 A558P Polymorphism NA 0.319 0.20 -63 0.208 O43280 R486W Polymorphism 0.842 0.475 0.13 16 0.614 O43280 T389A Polymorphism 0.237 0.140 0.76 -56 0.095 O43280 Y449H Polymorphism 0.559 0.377 0.03 48 0.597 O43283 E44K Polymorphism NA 0.174 0.02 1 0.037 O43283 R517G Polymorphism 0.129 0.347 0.04 28 0.377 O43286 D368N Polymorphism 0.375 0.444 0.86 11 0.294 O43290 G485A Polymorphism 0.177 0.122 0.20 -59 0.099 O43290 R245C Polymorphism 0.821 0.333 0.00 30 0.599 O43291 V200L Polymorphism 0.149 0.124 0.28 -23 0.177 O43291 Y163C Disease 0.782 0.691 0.00 72 0.924 O43295 I628V Polymorphism 0.097 0.072 0.26 -26 0.113 O43296 R183H Polymorphism 0.536 0.348 0.57 -7 0.534 O43303 R69S Polymorphism NA 0.258 NA 35 0.198 O43303 F347I Polymorphism NA 0.306 NA 37 0.139 O43307 G55A Disease 0.125 0.588 0.50 22 0.247 O43312 N305I Polymorphism 0.539 0.340 0.15 22 0.537 O43312 T725A Polymorphism 0.063 0.071 0.13 -2 0.086 O43313 K305E Polymorphism NA 0.320 0.00 41 0.213 O43313 S240P Polymorphism NA 0.281 0.00 47 0.254 O43314 P1206Q Polymorphism 0.051 0.126 0.10 14 0.097 O43316 R39Q Polymorphism 0.924 0.942 0.00 49 0.936 O43316 R172W Disease 0.859 0.888 0.00 30 0.890 O43316 R191C Polymorphism 0.342 0.935 0.00 26 0.747 O43316 R200H Polymorphism 0.966 0.923 0.01 49 0.952 O43316 R200S Polymorphism 0.953 0.938 0.07 24 0.923 O43323 L162P Disease 0.928 0.989 0.00 64 0.952 O43345 D907G Polymorphism NA 0.303 1.00 47 0.263 O43345 E282K Polymorphism 0.575 0.423 0.08 41 0.608 O43345 L1165H Polymorphism NA 0.666 0.00 -1 0.423 O43353 I259T Polymorphism 0.119 0.636 0.60 2 0.094 O43374 M352V Polymorphism 0.350 0.443 0.04 21 0.415 O43374 Y731C Polymorphism 0.858 0.607 0.00 39 0.792 O43379 K289R Polymorphism NA 0.517 0.07 53 0.608 O43379 G1370S Polymorphism NA 0.037 0.40 -53 0.028 O43379 Q1305L Polymorphism NA 0.077 0.11 -36 0.037 O43379 Q1311E Polymorphism NA 0.077 0.06 -24 0.044 O43395 P493S Disease 0.912 0.922 0.00 39 0.921 O43395 T494M Disease 0.917 0.878 0.00 35 0.898 O43405 G88E Disease NA 0.400 0.05 67 0.619 O43405 P51S Disease NA 0.345 0.00 57 0.660 O43405 V66G Disease NA 0.330 0.00 51 0.643 O43405 A119T Disease NA 0.168 0.26 39 0.264 O43405 D281N Polymorphism 0.095 0.374 0.41 7 0.221 O43405 G135R Polymorphism NA 0.255 0.32 49 0.244 O43405 I109N Disease NA 0.395 0.26 46 0.541 O43405 T352S Polymorphism 0.139 0.495 1.00 -49 0.112 O43405 W117R Disease NA 0.500 0.14 57 0.733 O43423 R71K Polymorphism 0.296 0.745 0.36 15 0.595 O43423 E204G Polymorphism 0.522 0.137 0.00 33 0.206 O43423 Y140H Polymorphism 0.759 0.910 0.05 -9 0.831 O43424 T68M Polymorphism 0.391 0.230 0.03 40 0.401 O43424 F398S Polymorphism 0.712 0.307 0.00 46 0.721 O43424 V490I Polymorphism 0.226 0.157 0.70 10 0.133 O43426 K295R Polymorphism 0.223 0.457 0.35 -32 0.300 O43426 P1547L Polymorphism NA 0.104 0.00 22 0.146 O43426 V1366A Polymorphism NA 0.122 0.66 23 0.063 O43427 M351V Polymorphism 0.123 0.433 NA 38 0.339 O43427 R152W Polymorphism 0.760 0.215 NA 8 0.373 O43432 D1185E Polymorphism 0.238 0.101 0.12 12 0.116 O43435 F148Y Disease 0.344 0.572 0.11 -13 0.400 O43435 G310S Disease 0.412 0.285 0.72 -47 0.205 O43435 H194Q Disease 0.424 0.618 0.01 47 0.766 O43435 T350M Polymorphism 0.168 0.088 0.12 38 0.076 O43451 Q404H Polymorphism 0.470 0.178 0.12 -14 0.237 O43451 L1638I Polymorphism NA 0.440 0.37 22 0.457 O43464 L72P Polymorphism 0.306 0.285 0.08 13 0.162 O43464 G399S Disease 0.526 0.777 0.17 42 0.721 O43474 L321F Polymorphism 0.158 0.066 0.30 24 0.047 O43488 C214Y Polymorphism 0.214 0.548 0.16 5 0.267 O43488 Q157H Polymorphism 0.069 0.135 0.24 -40 0.087 O43488 S255N Polymorphism NA 0.210 0.55 -41 0.194 O43490 A31G Polymorphism 0.561 0.148 0.44 -38 0.058 O43490 R373C Disease 0.776 0.311 0.15 9 0.487 O43491 Q17H Polymorphism NA 0.315 0.00 6 0.428 O43493 A86G Polymorphism 0.175 0.067 0.26 30 0.045 O43493 E322G Polymorphism 0.269 0.070 0.03 32 0.064 O43493 Q105P Polymorphism 0.113 0.075 0.28 15 0.029 O43502 I144T Polymorphism 0.600 0.757 0.00 29 0.668 O43505 T253S Polymorphism 0.121 0.116 0.41 -12 0.111 O43506 F19L Polymorphism NA 0.526 1.00 -56 0.360 O43511 E29Q Disease 0.299 0.589 0.58 -5 0.343 O43511 S28R Disease 0.562 0.648 0.17 33 0.579 O43511 S90L Disease 0.744 0.846 0.02 22 0.867 O43511 Y78C Disease 0.998 0.899 0.00 65 0.948 O43511 A106D Disease 0.726 0.943 0.00 49 0.911 O43511 A372V Disease 0.546 0.826 0.01 41 0.851 O43511 A411P Disease 0.743 0.873 0.22 29 0.638 O43511 C565Y Disease 0.387 0.476 0.10 28 0.440 O43511 D271H Disease 0.887 0.817 0.03 29 0.848 O43511 D724N Disease 0.453 0.941 0.02 27 0.751 O43511 E384G Disease 0.982 0.859 0.00 57 0.932 O43511 F335L Disease 0.588 0.184 0.87 -2 0.272 O43511 F667C Disease 0.980 0.949 0.14 61 0.952 O43511 G102R Disease 0.986 0.927 0.01 54 0.944 O43511 G139A Disease 0.987 0.816 0.00 48 0.892 O43511 G209V Disease 0.979 0.905 0.00 35 0.934 O43511 G497S Disease 0.988 0.840 0.00 38 0.916 O43511 G672E Disease 0.360 0.876 0.01 51 0.867 O43511 H723R Disease 0.952 0.947 0.03 52 0.968 O43511 I455F Disease 0.589 0.885 0.01 -17 0.530 O43511 I490L Disease 0.264 0.230 0.60 -19 0.242 O43511 K369E Disease 0.415 0.706 0.41 24 0.503 O43511 L117F Disease 0.614 0.889 0.00 44 0.778 O43511 L236P Disease 0.880 0.928 0.02 47 0.894 O43511 L445W Disease 0.995 0.803 0.00 56 0.931 O43511 L676Q Disease 0.850 0.925 0.00 39 0.891 O43511 M147V Disease 0.865 0.692 0.04 42 0.784 O43511 M775T Disease 0.029 0.215 0.00 18 0.210 O43511 N324Y Polymorphism 0.679 0.520 0.06 24 0.763 O43511 N392Y Disease 0.977 0.815 0.00 50 0.925 O43511 N457K Disease 0.948 0.831 0.15 36 0.874 O43511 P123S Disease 0.965 0.643 0.10 27 0.881 O43511 P301L Polymorphism 0.994 0.739 1.00 -1 0.794 O43511 Q446R Disease 0.493 0.837 0.08 47 0.878 O43511 Q514R Disease 0.934 0.700 0.23 43 0.866 O43511 R409H Disease 0.959 0.885 0.03 75 0.930 O43511 R409P Disease 0.961 0.928 0.02 79 0.929 O43511 S133T Disease 0.859 0.618 0.08 64 0.759 O43511 S137P Disease 0.929 0.773 0.10 30 0.890 O43511 S252P Disease 0.756 0.918 0.21 45 0.728 O43511 S391N Disease 0.693 0.454 0.14 24 0.646 O43511 S552I Disease 0.823 0.511 0.01 47 0.838 O43511 S666F Disease 0.565 0.509 0.07 35 0.765 O43511 S694P Disease 0.303 0.864 0.29 40 0.593 O43511 T132I Disease 0.946 0.760 0.01 53 0.921 O43511 T193I Disease 0.720 0.780 0.01 15 0.802 O43511 T410M Disease 0.787 0.885 0.00 62 0.914 O43511 T416P Disease 0.903 0.939 0.04 52 0.933 O43511 T508N Disease 0.798 0.500 0.37 33 0.678 O43511 T721M Disease 0.792 0.883 0.01 45 0.886 O43511 V138F Disease 0.797 0.843 0.02 50 0.832 O43511 V239D Disease 0.857 0.822 0.00 45 0.881 O43511 V402M Disease 0.453 0.476 0.09 16 0.562 O43511 V480D Disease 0.821 0.718 0.02 60 0.914 O43511 V609G Polymorphism 0.172 0.428 0.50 11 0.221 O43511 V653A Disease 0.541 0.289 0.84 14 0.478 O43511 Y105C Disease 0.843 0.940 0.00 54 0.930 O43511 Y530H Disease 0.945 0.796 0.00 52 0.929 O43511 Y530S Disease 0.964 0.827 0.00 52 0.936 O43511 Y556C Disease 0.895 0.889 0.00 66 0.937 O43511 Y556H Disease 0.629 0.811 0.00 66 0.912 O43520 D70N Disease 0.099 0.749 0.73 0 0.260 O43520 N45T Disease 0.108 0.070 0.00 17 0.150 O43520 D454G Disease 0.999 0.940 0.00 67 0.938 O43520 D554N Disease 0.992 0.849 0.00 58 0.935 O43520 D688G Disease NA 0.339 0.07 26 0.411 O43520 E429A Polymorphism NA 0.305 0.25 17 0.378 O43520 F305I Polymorphism 0.100 0.547 0.03 42 0.420 O43520 F853S Disease 0.706 0.874 0.00 60 0.909 O43520 G308D Disease 0.992 0.933 0.00 62 0.936 O43520 G308V Disease 0.994 0.928 0.00 53 0.933 O43520 G733R Disease 0.997 0.853 0.00 73 0.936 O43520 G892R Disease 0.854 0.909 0.00 77 0.923 O43520 H535L Disease 0.787 0.896 0.00 63 0.918 O43520 I344F Disease 0.703 0.902 0.04 22 0.813 O43520 I661T Disease 0.393 0.446 0.02 47 0.602 O43520 I694T Disease 0.526 0.787 0.01 41 0.839 O43520 K203E Disease 0.116 0.444 1.00 -10 0.145 O43520 L127P Disease 0.876 0.893 0.08 31 0.874 O43520 L288S Disease 0.826 0.903 0.00 50 0.910 O43520 R412P Disease 0.733 0.963 0.02 72 0.936 O43520 R600Q Disease 0.700 0.908 0.01 63 0.915 O43520 R600W Disease 0.943 0.939 0.00 62 0.924 O43520 R628W Disease 0.906 0.827 0.00 60 0.917 O43520 R867C Disease 0.993 0.906 0.00 70 0.934 O43520 R952Q Polymorphism 0.503 0.500 0.30 -34 0.365 O43520 S403Y Disease 0.879 0.889 0.00 42 0.885 O43520 S453Y Disease 0.984 0.865 0.00 54 0.931 O43520 S580N Polymorphism NA 0.188 0.47 -23 0.170 O43520 T456M Disease 0.997 0.882 0.00 61 0.937 O43520 Y500H Disease NA 0.484 0.54 -34 0.303 O43520 A1152T Polymorphism NA 0.085 0.29 -56 0.154 O43520 G1040R Disease NA 0.887 0.00 61 0.906 O43525 D305G Disease 0.421 0.881 0.02 60 0.849 O43525 G310V Disease 0.976 0.901 0.03 54 0.939 O43525 W309R Disease 0.977 0.945 0.00 68 0.947 O43526 A306T Disease 0.878 0.939 0.02 11 0.888 O43526 H228Q Disease 0.970 0.490 0.07 39 0.764 O43526 K554N Disease 0.564 0.927 0.05 47 0.723 O43526 L243F Disease 0.885 0.735 0.03 19 0.849 O43526 M208V Disease 0.888 0.334 0.19 3 0.595 O43526 R207W Disease 0.988 0.916 0.01 32 0.940 O43526 R214W Disease 0.901 0.886 0.01 18 0.911 O43526 R333Q Disease 0.598 0.895 0.10 48 0.749 O43526 S247W Disease 0.989 0.888 0.00 31 0.940 O43526 Y284C Disease 0.781 0.787 0.16 8 0.778 O43529 V20L Polymorphism 0.144 0.214 0.53 -7 0.119 O43542 R94H Polymorphism NA 0.350 0.28 -9 0.187 O43543 I221T Polymorphism 0.146 0.095 0.24 28 0.080 O43543 R188H Polymorphism 0.158 0.104 0.06 -16 0.083 O43548 P67S Polymorphism NA 0.898 0.05 22 0.644 O43548 A352G Polymorphism 0.058 0.186 1.00 -34 0.115 O43548 G113C Disease 0.966 0.899 0.00 56 0.945 O43548 T109M Polymorphism NA 0.121 0.03 10 0.238 O43548 V504M Polymorphism NA 0.086 0.06 0 0.163 O43555 A16V Polymorphism NA 0.120 0.00 -63 0.068 O43556 L196R Disease 0.812 0.957 0.00 54 0.938 O43556 P399H Polymorphism 0.209 0.711 0.00 28 0.686 O43557 S32L Polymorphism 0.037 0.074 0.02 4 0.083 O43559 P221L Polymorphism 0.203 0.162 0.16 15 0.132 O43572 R249H Polymorphism 0.120 0.030 0.68 -7 0.040 O43581 I332N Polymorphism 0.385 0.845 0.02 20 0.769 O43586 A151S Polymorphism 0.172 0.124 0.71 -25 0.222 O43586 A230T Disease 0.415 0.203 0.45 12 0.348 O43586 E106K Polymorphism 0.306 0.289 0.30 33 0.377 O43586 E250Q Disease 0.745 0.803 0.11 29 0.702 O43586 Q146H Polymorphism 0.303 0.262 0.53 1 0.336 O43592 A526V Polymorphism 0.309 0.412 0.61 -1 0.274 O43592 E716D Polymorphism 0.441 0.244 0.80 5 0.142 O43593 G337D Polymorphism 0.423 0.163 1.00 27 0.068 O43593 P924L Polymorphism 0.607 0.189 0.39 -4 0.291 O43593 R620Q Polymorphism 0.384 0.192 0.41 51 0.388 O43593 D1012N Disease 0.257 0.939 0.00 51 0.876 O43593 T1022A Disease 0.089 0.087 0.74 32 0.097 O43593 V1136D Disease 0.704 0.938 0.00 60 0.929 O43602 A152S Disease NA 0.667 0.07 15 0.552 O43602 A332S Disease 0.228 0.861 0.05 40 0.705 O43602 A332V Disease 0.304 0.841 0.02 45 0.649 O43602 D143N Disease NA 0.911 0.00 44 0.837 O43602 D167H Disease NA 0.564 0.06 24 0.558 O43602 F324L Disease 0.196 0.591 0.98 25 0.358 O43602 G148E Disease NA 0.940 0.00 62 0.918 O43602 G181A Disease NA 0.887 0.14 9 0.591 O43602 G304E Disease NA 0.850 0.00 65 0.865 O43602 G304V Disease NA 0.892 0.00 52 0.881 O43602 G334D Disease 0.497 0.907 0.00 67 0.915 O43602 I185T Disease NA 0.917 0.01 21 0.807 O43602 I295T Disease NA 0.668 0.06 35 0.775 O43602 I331N Disease 0.586 0.678 0.00 49 0.818 O43602 I331T Disease 0.365 0.601 0.01 36 0.697 O43602 K131N Disease NA 0.193 0.20 12 0.314 O43602 L124S Disease NA 0.652 0.61 -2 0.434 O43602 L178R Disease NA 0.988 0.01 53 0.889 O43602 N141D Disease NA 0.873 0.16 61 0.835 O43602 N281I Disease NA 0.877 0.02 42 0.823 O43602 N281K Disease NA 0.876 0.08 30 0.811 O43602 P272L Disease NA 0.752 0.31 -2 0.524 O43602 P272R Disease NA 0.843 0.03 -3 0.742 O43602 R140H Disease NA 0.577 0.01 35 0.774 O43602 R140L Disease NA 0.776 0.01 43 0.796 O43602 R159L Disease NA 0.593 0.07 32 0.515 O43602 R170G Disease NA 0.706 0.03 20 0.551 O43602 R183S Disease NA 0.955 0.00 47 0.870 O43602 R259C Disease NA 0.438 0.05 32 0.532 O43602 R259L Disease NA 0.367 0.27 15 0.410 O43602 R267C Disease NA 0.855 0.00 46 0.805 O43602 R273W Disease NA 0.700 0.00 22 0.769 O43602 R277H Disease NA 0.710 0.08 43 0.662 O43602 S128R Disease NA 0.487 0.01 37 0.475 O43602 T123I Disease NA 0.532 0.10 -11 0.469 O43602 T284A Disease NA 0.434 0.40 41 0.365 O43602 T284R Disease NA 0.765 0.03 48 0.737 O43602 T303I Disease NA 0.358 0.01 30 0.453 O43602 V317I Disease 0.138 0.333 0.05 39 0.255 O43602 Y206D Disease NA 0.935 0.00 64 0.934 O43602 Y206H Disease NA 0.866 0.00 67 0.910 O43612 L16R Disease 0.697 0.591 0.00 49 0.812 O43613 G167S Polymorphism 0.188 0.570 0.01 -20 0.336 O43613 R279Q Polymorphism 0.170 0.648 0.56 8 0.265 O43613 R281H Polymorphism 0.297 0.646 0.13 4 0.454 O43638 P292A Polymorphism NA 0.064 1.00 37 0.067 O43657 A108T Polymorphism 0.254 0.653 0.09 -12 0.430 O43663 Y511C Polymorphism 0.319 0.172 0.18 0 0.150 O43665 A94V Polymorphism 0.617 0.860 0.01 44 0.675 O43681 N332S Polymorphism 0.313 0.152 0.69 -47 0.120 O43683 G20D Polymorphism 0.868 0.877 0.00 47 0.895 O43683 N534D Polymorphism 0.644 0.037 0.03 11 0.100 O43699 L57V Polymorphism 0.422 0.372 0.51 12 0.313 O43699 L262F Polymorphism 0.715 0.806 0.04 49 0.788 O43707 K255E Disease 0.457 0.928 0.04 43 0.853 O43707 S262P Disease 0.718 0.918 0.09 67 0.927 O43707 T259I Disease 0.622 0.887 0.00 42 0.866 O43708 K32E Polymorphism 0.866 0.321 1.00 -61 0.019 O43708 N133H Polymorphism 0.560 0.244 1.00 -66 0.296 O43716 S3L Polymorphism 0.148 0.116 0.00 4 0.135 O43719 D678G Polymorphism NA 0.073 0.00 33 0.065 O43719 G478A Polymorphism NA 0.079 0.14 -4 0.053 O43736 A72V Polymorphism 0.453 0.506 0.66 -9 0.396 O43736 R230T Polymorphism 0.577 0.686 0.01 53 0.855 O43745 R127P Polymorphism 0.516 0.832 0.14 31 0.850 O43747 P685H Polymorphism 0.316 0.288 0.13 24 0.340 O43747 V195G Polymorphism 0.882 0.661 0.01 24 0.817 O43772 D231H Disease 0.977 0.893 0.00 59 0.917 O43772 Q238R Disease 0.969 0.857 0.07 60 0.889 O43772 R133W Disease 0.904 0.837 0.02 37 0.906 O43790 E402K Disease 0.876 0.941 0.00 50 0.887 O43790 E402Q Disease 0.926 0.862 0.00 41 0.875 O43790 E413D Disease 0.799 0.494 0.00 31 0.818 O43790 E413K Disease 0.895 0.769 0.00 48 0.856 O43790 N114D Disease 0.793 0.841 0.00 38 0.856 O43790 N114H Disease 0.961 0.820 0.00 47 0.910 O43808 H98R Polymorphism 0.152 0.406 0.57 -1 0.151 O43819 R20P Polymorphism NA 0.139 0.30 29 0.017 O43819 A259V Polymorphism 0.513 0.203 0.28 -7 0.444 O43819 E140K Disease 0.566 0.695 0.41 46 0.845 O43819 R171W Disease 0.976 0.931 0.00 56 0.938 O43819 S225F Disease 0.941 0.779 0.00 57 0.920 O43820 H113Y Polymorphism 0.089 0.164 0.18 -9 0.142 O43822 G153S Polymorphism 0.205 0.161 0.35 -22 0.120 O43826 G20D Disease 0.944 0.964 0.07 70 0.946 O43826 G50R Disease 0.711 0.875 0.03 71 0.914 O43826 G68R Disease 0.711 0.910 0.08 72 0.925 O43826 G88D Disease 0.638 0.816 0.16 58 0.904 O43826 L85P Disease 0.558 0.887 0.00 45 0.863 O43826 N27K Disease 0.423 0.567 0.51 35 0.780 O43826 R28C Disease 0.995 0.945 0.08 72 0.952 O43826 R28H Disease 0.992 0.891 0.18 73 0.946 O43826 S54R Disease 0.541 0.902 0.04 55 0.902 O43826 S55R Disease 0.541 0.636 0.43 44 0.792 O43826 Y24H Disease 0.569 0.721 0.42 64 0.882 O43826 A367T Disease 0.385 0.679 0.15 51 0.714 O43826 A373D Disease 0.571 0.929 0.18 56 0.918 O43826 C176R Disease 0.679 0.577 0.01 50 0.861 O43826 C183R Disease 0.715 0.616 0.13 39 0.784 O43826 G149E Disease 0.637 0.859 0.17 52 0.728 O43826 G150R Disease 0.226 0.782 0.05 31 0.710 O43826 G339C Disease 0.971 0.969 0.03 59 0.954 O43826 G339D Disease 0.950 0.977 0.02 72 0.948 O43826 G376S Disease 0.989 0.936 0.02 47 0.953 O43826 H301P Disease 0.686 0.685 0.37 28 0.650 O43826 I278N Disease 0.691 0.872 0.00 35 0.868 O43826 L229P Disease 0.750 0.924 0.01 57 0.933 O43826 P153L Disease 0.666 0.713 0.21 17 0.818 O43826 P191L Disease 0.994 0.819 0.01 43 0.913 O43826 Q133P Disease 0.621 0.927 0.05 56 0.926 O43826 R300H Disease 0.937 0.885 0.37 29 0.901 O43826 W118R Disease 0.702 0.817 0.32 74 0.907 O43827 E51D Polymorphism 0.090 0.236 0.22 -17 0.193 O43827 R140H Polymorphism 0.462 0.399 0.12 31 0.435 O43837 L132P Disease 0.957 0.926 0.00 60 0.945 O43852 R4Q Polymorphism NA 0.070 0.41 -63 0.066 O43861 S39G Polymorphism 0.024 0.072 NA 41 0.058 O43861 M732L Polymorphism 0.149 0.217 1.00 -4 0.150 O43866 D117E Polymorphism 0.059 0.352 0.80 -34 0.128 O43868 L12P Polymorphism 0.210 0.355 0.03 23 0.448 O43868 P22L Polymorphism 0.495 0.112 0.39 -5 0.099 O43868 F355S Polymorphism 0.850 0.692 0.01 27 0.858 O43868 G509E Polymorphism 0.752 0.610 0.01 29 0.705 O43868 L163W Polymorphism 0.935 0.704 0.00 27 0.868 O43868 L462F Polymorphism 0.249 0.599 0.02 -7 0.432 O43868 M612T Polymorphism 0.077 0.132 0.75 0 0.029 O43868 S245T Polymorphism 0.269 0.422 0.19 -40 0.282 O43869 H25R Polymorphism NA 0.124 NA 21 0.075 O43914 Y111H Polymorphism 0.603 0.308 0.17 30 0.370 O43918 A21V Disease NA 0.333 0.00 41 0.577 O43918 F77S Disease NA 0.647 0.16 39 0.716 O43918 K83E Disease NA 0.394 0.37 40 0.459 O43918 L28P Disease NA 0.519 0.01 35 0.712 O43918 L29P Disease NA 0.544 0.00 65 0.796 O43918 L93R Disease NA 0.582 0.00 64 0.789 O43918 R15C Disease NA 0.278 0.00 54 0.303 O43918 R15L Disease NA 0.500 0.05 45 0.694 O43918 T16M Disease NA 0.535 0.13 52 0.709 O43918 V80L Disease NA 0.116 0.27 -22 0.091 O43918 W78R Disease NA 0.545 0.10 50 0.708 O43918 Y85C Disease NA 0.418 0.03 49 0.652 O43918 Y90C Disease NA 0.457 0.01 54 0.704 O43918 C311Y Disease 0.486 0.908 0.00 76 0.924 O43918 G228W Disease NA 0.494 0.02 48 0.705 O43918 P252L Disease NA 0.056 0.74 -1 0.071 O43918 P326L Disease 0.213 0.530 0.02 28 0.624 O43918 P326Q Disease 0.259 0.644 0.01 40 0.669 O43918 P539L Disease NA 0.174 0.00 27 0.352 O43918 S278R Polymorphism NA 0.139 0.55 -16 0.050 O43918 V301M Disease 0.203 0.823 0.01 35 0.683 O43929 L56V Polymorphism NA 0.090 0.29 -50 0.117 O43933 G593R Disease NA 0.204 0.55 14 0.256 O43933 G843D Disease 0.387 0.935 0.00 75 0.921 O43933 L590R Disease NA 0.479 0.05 11 0.515 O43933 L664P Disease 0.726 0.778 0.00 64 0.900 O43933 R798G Disease 0.240 0.529 0.02 45 0.625 O43933 R948Q Polymorphism 0.225 0.424 0.18 8 0.322 O43933 A1237E Disease NA 0.306 NA 44 0.488 O60216 G481R Polymorphism 0.201 0.150 0.48 36 0.158 O60218 P87S Polymorphism 0.564 0.102 0.38 -48 0.168 O60220 C66W Disease 0.977 0.973 0.00 70 0.971 O60225 E19Q Polymorphism 0.174 0.513 0.00 -15 0.446 O60229 S196L Polymorphism 0.345 0.216 0.24 4 0.215 O60229 R1929M Polymorphism 0.655 0.796 0.01 50 0.840 O60231 D566G Polymorphism 0.601 0.401 0.45 -3 0.548 O60231 K352E Polymorphism NA 0.257 1.00 -3 0.197 O60232 T21M Polymorphism NA 0.030 NA -54 0.052 O60234 E122K Polymorphism 0.388 0.633 0.01 44 0.610 O60237 V182I Polymorphism NA 0.450 0.09 -31 0.242 O60240 K210E Polymorphism 0.338 0.078 0.85 34 0.086 O60240 P194A Polymorphism 0.072 0.074 0.14 -12 0.105 O60260 A46P Disease NA 0.866 0.02 58 0.894 O60260 A82E Disease NA 0.254 0.00 30 0.285 O60260 A92V Disease NA 0.070 0.03 16 0.091 O60260 P37L Disease NA 0.347 0.00 41 0.530 O60260 R33Q Disease NA 0.044 0.23 29 0.107 O60260 R42P Disease NA 0.796 0.01 57 0.883 O60260 V15M Disease NA 0.463 0.02 44 0.576 O60260 A339S Polymorphism 0.271 0.256 0.41 4 0.315 O60260 C212Y Disease 0.843 0.912 1.00 24 0.859 O60260 C253Y Disease 0.836 0.955 0.01 73 0.946 O60260 C289G Disease 0.510 0.944 0.01 43 0.829 O60260 C431F Disease 0.767 0.919 0.00 46 0.872 O60260 C441R Disease 0.998 0.930 0.00 77 0.969 O60260 D280N Disease 0.286 0.375 0.53 -23 0.270 O60260 D394N Polymorphism NA 0.325 0.44 -6 0.256 O60260 G284R Disease 0.791 0.938 0.24 49 0.909 O60260 G328E Disease 0.733 0.464 0.82 56 0.468 O60260 G430D Disease 0.691 0.881 0.00 77 0.912 O60260 K161N Disease NA 0.405 0.00 36 0.556 O60260 K211N Disease 0.590 0.751 0.01 20 0.799 O60260 K211R Disease 0.360 0.669 0.06 6 0.642 O60260 M192L Polymorphism NA 0.165 0.67 -17 0.191 O60260 M192V Disease NA 0.194 0.02 -16 0.246 O60260 P437L Disease 0.341 0.117 0.08 21 0.261 O60260 Q100H Polymorphism NA 0.073 0.01 22 0.116 O60260 R256C Disease 0.721 0.579 0.05 66 0.901 O60260 R275W Disease 0.906 0.712 0.02 48 0.888 O60260 R334C Disease 0.678 0.334 0.19 24 0.512 O60260 S167N Polymorphism NA 0.068 0.67 27 0.095 O60260 T240M Disease 0.495 0.142 0.03 42 0.284 O60260 T240R Disease 0.383 0.378 0.01 46 0.577 O60260 T351P Disease 0.426 0.612 0.08 30 0.739 O60260 T415N Disease 0.576 0.786 0.03 41 0.739 O60260 V380L Polymorphism 0.089 0.083 0.67 -22 0.078 O60266 S107P Polymorphism 0.312 0.556 0.20 34 0.420 O60269 R40H Polymorphism NA 0.260 NA 36 0.141 O60269 W91R Polymorphism NA 0.097 NA 2 0.016 O60279 L52F Polymorphism NA 0.110 NA 26 0.172 O60279 E378D Polymorphism NA 0.029 NA -46 0.006 O60279 R216K Polymorphism NA 0.181 NA -3 0.163 O60279 R228K Polymorphism NA 0.074 NA -4 0.057 O60287 P2071R Polymorphism NA 0.329 NA 25 0.236 O60290 I178T Polymorphism NA 0.169 NA 43 0.172 O60292 G1371S Polymorphism 0.383 0.031 0.59 0 0.065 O60293 K1807R Polymorphism 0.237 0.409 NA -6 0.156 O60294 V67L Polymorphism 0.284 0.550 0.06 -32 0.420 O60294 C149Y Polymorphism 0.504 0.223 0.36 33 0.499 O60296 I863N Polymorphism 0.315 0.163 0.01 -31 0.147 O60296 T528I Polymorphism 0.653 0.329 0.09 -13 0.512 O60303 A535S Polymorphism 0.228 0.199 NA -24 0.283 O60303 R885Q Polymorphism 0.391 0.177 NA 2 0.184 O60303 T522M Polymorphism 0.264 0.109 NA 26 0.093 O60303 R1368Q Polymorphism 0.179 0.016 NA -11 0.013 O60307 G883S Polymorphism NA 0.104 0.88 12 0.100 O60307 R203Q Polymorphism NA 0.276 0.01 36 0.373 O60312 A1397V Polymorphism NA 0.072 0.35 21 0.050 O60312 I1188V Polymorphism NA 0.324 0.98 -44 0.253 O60312 R1298S Polymorphism NA 0.292 0.51 -3 0.174 O60312 V1198M Polymorphism NA 0.275 0.31 -17 0.342 O60312 W1172C Polymorphism NA 0.861 0.03 30 0.724 O60313 A192V Polymorphism 0.476 0.124 0.02 -11 0.156 O60313 G300E Disease 0.997 0.921 0.00 68 0.958 O60313 L396R Disease 0.781 0.942 0.00 61 0.929 O60313 L939P Disease 0.807 0.326 0.00 47 0.611 O60313 R290Q Disease 0.612 0.557 0.32 -21 0.355 O60313 R445H Disease 0.751 0.696 0.02 35 0.862 O60313 R571H Disease 0.526 0.219 0.50 51 0.424 O60313 S158N Polymorphism 0.089 0.089 0.06 -5 0.081 O60313 S545R Disease 0.620 0.211 0.24 46 0.296 O60313 T503K Disease 0.633 0.797 0.26 52 0.705 O60315 R953G Disease NA 0.600 0.03 62 0.738 O60315 Q1119R Disease NA 0.096 0.08 46 0.096 O60318 M288V Polymorphism NA 0.094 0.11 18 0.063 O60318 P413L Polymorphism NA 0.087 0.01 -2 0.154 O60318 R333L Polymorphism NA 0.323 NA 42 0.219 O60318 S102L Polymorphism NA 0.109 0.02 43 0.180 O60318 R1314W Polymorphism 0.334 0.043 0.02 8 0.070 O60318 V1576I Polymorphism 0.470 0.031 NA 9 0.107 O60320 G314D Polymorphism NA 0.054 1.00 3 0.022 O60331 D253N Disease 0.692 0.917 0.00 34 0.868 O60333 Q98L Disease 0.972 0.932 0.00 54 0.941 O60336 L313V Polymorphism NA 0.182 0.10 -19 0.226 O60336 Y204S Polymorphism NA 0.203 0.39 36 0.276 O60337 P622L Polymorphism 0.431 0.283 1.00 28 0.299 O60343 V819I Polymorphism 0.086 0.081 0.05 -28 0.016 O60343 T1147M Polymorphism NA 0.101 0.12 45 0.270 O60344 H101Y Polymorphism NA 0.156 0.70 0 0.015 O60344 R571Q Polymorphism 0.415 0.215 0.49 -54 0.163 O60346 S1118T Polymorphism 0.122 0.119 0.34 -5 0.152 O60353 M345L Polymorphism 0.062 0.753 0.54 -23 0.204 O60391 A845T Polymorphism NA 0.487 0.08 11 0.591 O60391 T577M Polymorphism 0.069 0.529 0.49 -37 0.037 O60393 D452N Polymorphism NA 0.067 0.64 -22 0.013 O60393 R355H Disease 0.853 0.463 0.01 61 0.801 O60404 R7S Polymorphism 0.516 0.271 0.43 -1 0.014 O60404 S293N Polymorphism 0.865 0.869 0.01 34 0.893 O60404 V224M Polymorphism 0.824 0.770 0.05 22 0.801 O60412 R122H Polymorphism 0.782 0.874 0.08 62 0.834 O60423 G45R Polymorphism NA 0.097 0.10 32 0.078 O60427 P272S Polymorphism 0.450 0.729 0.06 23 0.584 O60431 I292T Polymorphism 0.340 0.601 0.00 18 0.501 O60437 H631Y Polymorphism 0.119 0.050 1.00 0 0.033 O60437 A1007V Polymorphism 0.146 0.058 0.26 11 0.097 O60437 E1199Q Polymorphism 0.389 0.056 0.43 29 0.099 O60437 Q1573E Polymorphism 0.189 0.079 0.72 -9 0.097 O60443 M174T Polymorphism 0.154 0.080 0.42 -1 0.029 O60443 V207M Polymorphism 0.665 0.213 0.04 36 0.458 O60447 Q612H Polymorphism 0.363 0.158 0.02 2 0.278 O60449 W20R Polymorphism NA 0.121 0.42 7 0.035 O60449 D692N Polymorphism 0.323 0.151 0.01 -12 0.276 O60449 D807E Polymorphism 0.223 0.194 0.76 -22 0.183 O60449 D884A Polymorphism 0.364 0.500 0.48 22 0.540 O60449 V666A Polymorphism 0.386 0.190 0.46 25 0.238 O60449 T1202S Polymorphism 0.337 0.151 0.77 6 0.130 O60449 T1393I Polymorphism 0.347 0.370 0.97 20 0.358 O60449 Y1391H Polymorphism 0.375 0.200 0.58 -13 0.242 O60462 R123K Polymorphism 0.215 0.389 1.00 -8 0.250 O60477 R358H Polymorphism NA 0.076 0.01 -25 0.081 O60481 C253S Disease 0.785 0.935 0.02 66 0.942 O60481 H286R Disease 0.996 0.559 0.04 65 0.975 O60481 K405E Disease 0.722 0.295 0.31 47 0.600 O60481 T323M Disease 0.897 0.393 0.00 55 0.698 O60481 W255G Disease 0.871 0.969 0.34 73 0.942 O60488 R570S Disease 0.993 0.875 0.00 65 0.941 O60494 F124I Polymorphism NA 0.600 0.82 7 0.450 O60494 P389T Polymorphism NA 0.569 0.42 40 0.485 O60494 C2162Y Polymorphism NA 0.629 1.00 15 0.175 O60494 E2968Q Polymorphism NA 0.714 0.16 42 0.576 O60494 G1840S Polymorphism 0.515 0.400 0.60 6 0.549 O60494 I2984V Polymorphism NA 0.058 0.45 21 0.172 O60494 L2153F Polymorphism NA 0.404 0.04 38 0.442 O60494 N1545Y Polymorphism 0.090 0.273 0.62 1 0.225 O60494 N3552K Polymorphism NA 0.488 0.48 33 0.296 O60494 P1297L Disease 0.665 0.875 0.00 32 0.808 O60494 P1971T Polymorphism NA 0.445 0.43 -15 0.282 O60494 S2717W Polymorphism NA 0.216 1.00 29 0.058 O60494 Y1032H Polymorphism 0.123 0.269 0.53 21 0.175 O60500 E117K Polymorphism NA 0.395 0.64 33 0.372 O60500 L392P Polymorphism 0.709 0.817 0.25 -9 0.630 O60500 T233A Polymorphism 0.236 0.210 0.19 1 0.263 O60500 V991L Polymorphism 0.110 0.237 0.62 12 0.242 O60500 N1077S Polymorphism 0.329 0.469 0.00 23 0.357 O60502 E602K Polymorphism 0.085 0.107 0.00 4 0.146 O60504 T573A Polymorphism NA 0.234 0.84 -21 0.224 O60513 Q116E Polymorphism 0.150 0.110 1.00 -38 0.083 O60522 R192Q Polymorphism NA 0.025 0.17 -1 0.045 O60522 Q1014E Polymorphism 0.308 0.123 0.94 -2 0.105 O60543 V115F Polymorphism 0.160 0.240 0.24 21 0.321 O60563 H362R Polymorphism 0.124 0.158 0.08 30 0.161 O60566 R36Q Disease NA 0.848 0.02 69 0.906 O60566 T40M Polymorphism NA 0.069 0.00 -7 0.158 O60566 E390D Polymorphism 0.522 0.042 0.28 15 0.083 O60566 I909T Disease 0.869 0.166 0.01 32 0.426 O60566 L844F Disease 0.925 0.241 0.01 56 0.597 O60566 P378S Polymorphism 0.726 0.177 NA 26 0.200 O60566 Q921H Disease 0.848 0.130 0.55 45 0.334 O60566 R349Q Polymorphism 0.676 0.025 NA -23 0.014 O60566 R550Q Disease 0.274 0.024 0.09 3 0.035 O60566 R814H Disease 0.992 0.775 0.02 58 0.960 O60566 L1012P Disease 0.982 0.667 0.00 64 0.949 O60568 A151V Polymorphism 0.559 0.452 1.00 19 0.579 O60568 N223S Disease 0.357 0.462 0.05 38 0.499 O60575 V7I Polymorphism 0.124 0.110 0.53 -70 0.050 O60602 F822L Polymorphism 0.354 0.323 0.65 -15 0.100 O60602 N592S Polymorphism 0.087 0.279 0.10 6 0.174 O60603 R753Q Polymorphism 0.425 0.737 0.04 55 0.664 O60603 T411I Polymorphism NA 0.144 0.19 28 0.308 O60635 V87M Polymorphism NA 0.237 0.12 -7 0.189 O60662 A271T Polymorphism NA 0.152 0.45 19 0.229 O60662 M481V Polymorphism 0.447 0.860 0.39 56 0.774 O60663 C36R Disease 0.997 0.929 0.00 80 0.949 O60663 C36S Disease 0.994 0.892 0.00 68 0.954 O60663 C57R Disease 0.997 0.884 0.00 74 0.950 O60663 C60F Disease 0.838 0.857 0.00 73 0.934 O60663 C60G Disease 0.687 0.793 0.00 70 0.913 O60663 C60W Disease 0.938 0.855 0.00 78 0.941 O60663 C60Y Disease 0.868 0.867 0.00 75 0.939 O60663 C63R Disease 0.997 0.875 0.00 85 0.932 O60663 C80W Disease 0.998 0.882 0.00 77 0.951 O60663 C95F Disease 0.838 0.894 0.00 72 0.933 O60663 C95Y Disease 0.868 0.907 0.00 72 0.939 O60663 D83G Disease 0.330 0.794 0.04 61 0.885 O60663 H54N Disease 0.997 0.749 0.00 70 0.950 O60663 H54Q Disease 0.997 0.775 0.00 70 0.949 O60663 H54Y Disease 0.995 0.774 0.00 73 0.948 O60663 L58W Disease 0.740 0.684 0.00 52 0.881 O60663 A213P Disease 0.584 0.772 0.18 19 0.838 O60663 A230V Disease 0.568 0.435 0.00 29 0.526 O60663 C117Y Disease 0.998 0.819 0.01 70 0.943 O60663 C120S Disease 0.995 0.752 0.00 68 0.944 O60663 C123F Disease 0.998 0.837 0.00 72 0.945 O60663 C123Y Disease 0.998 0.853 0.00 73 0.946 O60663 C142W Disease 0.998 0.867 0.01 64 0.947 O60663 H114Y Disease 0.995 0.653 0.00 71 0.945 O60663 L229P Disease 0.842 0.928 0.00 35 0.890 O60663 N246K Disease 0.993 0.627 0.00 42 0.891 O60663 R200Q Disease 0.614 0.698 0.00 38 0.841 O60663 R226P Disease 0.791 0.891 0.00 57 0.915 O60663 S218P Disease 0.690 0.655 0.01 8 0.775 O60663 W243C Disease 0.997 0.808 0.00 56 0.950 O60664 I56V Polymorphism 0.075 0.068 1.00 -5 0.025 O60671 H39Q Polymorphism 0.186 0.315 0.30 4 0.227 O60671 E281G Polymorphism 0.267 0.056 NA 6 0.054 O60673 S389T Polymorphism NA 0.261 0.01 32 0.186 O60673 S633G Polymorphism NA 0.154 0.00 38 0.168 O60673 D1713N Polymorphism NA 0.190 0.00 -16 0.212 O60673 G1923R Polymorphism NA 0.243 0.00 -15 0.261 O60673 K1540E Polymorphism NA 0.426 0.00 17 0.268 O60673 P1339T Polymorphism NA 0.213 0.15 -20 0.133 O60673 P1791S Polymorphism NA 0.129 0.00 -33 0.034 O60673 R2762Q Polymorphism 0.460 0.776 0.06 10 0.525 O60673 S1724T Polymorphism NA 0.257 0.03 21 0.175 O60673 S2607T Polymorphism 0.280 0.474 0.09 -31 0.240 O60673 T1224I Polymorphism NA 0.101 0.13 -36 0.017 O60673 V3064I Polymorphism 0.190 0.163 0.05 21 0.182 O60674 A377E Polymorphism 0.343 0.735 0.01 37 0.582 O60674 D584E Polymorphism 0.554 0.384 0.26 30 0.574 O60674 G127D Polymorphism 0.580 0.649 0.13 40 0.653 O60674 K346R Polymorphism 0.109 0.112 0.84 -20 0.113 O60674 K607N Disease 0.456 0.808 0.10 23 0.710 O60674 L393V Polymorphism 0.526 0.119 1.00 -19 0.127 O60674 V617F Disease 0.516 0.877 0.07 58 0.904 O60674 R1063H Polymorphism NA 0.312 0.02 -24 0.432 O60676 A142P Polymorphism 0.730 0.311 0.04 30 0.590 O60678 S470C Polymorphism 0.693 0.886 0.00 53 0.906 O60683 H290Q Disease 0.848 0.941 0.00 80 0.951 O60687 Y72S Disease 0.641 0.133 0.37 26 0.073 O60687 N327S Disease 0.311 0.044 0.80 5 0.110 O60706 A1513T Disease 0.398 0.222 0.18 -3 0.318 O60711 P148T Polymorphism 0.533 0.587 0.10 14 0.541 O60721 V311L Polymorphism NA 0.199 0.00 33 0.367 O60729 I302T Polymorphism 0.804 0.567 0.35 15 0.726 O60732 F276S Polymorphism NA 0.138 NA 15 0.025 O60732 H327Q Polymorphism NA 0.071 NA 12 0.037 O60732 T151I Polymorphism NA 0.154 NA 19 0.099 O60733 R63G Polymorphism NA 0.178 0.19 52 0.278 O60733 R70Q Polymorphism NA 0.221 0.07 46 0.292 O60733 V58I Polymorphism NA 0.239 0.46 22 0.257 O60733 D183N Polymorphism 0.259 0.695 0.23 21 0.374 O60733 K545T Disease 0.498 0.578 0.19 41 0.744 O60733 R632W Disease 0.765 0.318 0.00 38 0.593 O60733 V310E Disease 0.650 0.257 0.01 49 0.623 O60755 R342G Polymorphism 0.497 0.175 0.41 34 0.276 O60759 Q83E Polymorphism 0.329 0.175 1.00 0 0.127 O60762 R92G Disease 0.784 0.737 0.20 43 0.769 O60762 S248P Disease 0.736 0.652 0.06 25 0.774 O60774 V127I Polymorphism 0.562 0.477 0.11 -25 0.507 O60779 D93H Disease 0.963 0.949 0.01 78 0.965 O60779 G172D Disease 0.444 0.720 0.04 47 0.824 O60779 S143F Disease 0.642 0.926 0.01 32 0.862 O60784 R84H Polymorphism 0.732 0.412 0.11 -6 0.598 O60784 M264V Polymorphism 0.281 0.832 0.16 42 0.606 O60806 S128F Disease 0.862 0.840 0.00 62 0.923 O60809 K99I Polymorphism 0.911 0.864 0.01 43 0.900 O60809 G402R Polymorphism 0.526 0.433 0.03 23 0.593 O60811 S68W Polymorphism 0.912 0.476 0.01 30 0.708 O60811 V67G Polymorphism 0.796 0.137 1.00 -43 0.040 O60811 A128T Polymorphism 0.292 0.089 0.29 -36 0.197 O60811 C375R Polymorphism 0.669 0.260 1.00 16 0.423 O60811 F316Y Polymorphism 0.384 0.208 1.00 1 0.132 O60811 L310M Polymorphism 0.503 0.534 0.22 21 0.462 O60811 N304Y Polymorphism 0.245 0.095 1.00 -12 0.101 O60811 T141M Polymorphism 0.290 0.051 0.48 0 0.081 O60811 T233N Polymorphism 0.734 0.072 1.00 -47 0.094 O60811 Y225C Polymorphism 0.519 0.188 0.07 19 0.160 O60812 Q208H Polymorphism 0.105 0.229 0.01 43 0.224 O60812 V258D Polymorphism 0.064 0.104 0.34 -21 0.024 O60832 A2V Disease NA 0.166 0.00 -23 0.347 O60832 E41K Disease 0.251 0.596 0.00 35 0.483 O60832 F36V Disease 0.725 0.646 0.00 31 0.785 O60832 I38T Disease 0.680 0.893 0.00 45 0.877 O60832 K39E Disease 0.285 0.823 0.00 20 0.523 O60832 L72Y Disease 0.534 0.793 0.38 7 0.662 O60832 P40R Disease 0.719 0.931 0.00 59 0.926 O60832 R65T Disease 0.662 0.943 0.00 57 0.923 O60832 T49M Disease 0.819 0.741 0.00 49 0.909 O60832 T66A Disease 0.374 0.736 0.02 33 0.688 O60832 A353V Disease 0.202 0.308 0.60 -3 0.235 O60832 G402E Disease 0.871 0.915 0.00 38 0.880 O60832 G402R Disease 0.902 0.910 0.00 41 0.908 O60832 L321V Disease 0.405 0.638 0.20 -2 0.453 O60832 M350I Disease 0.632 0.871 0.07 48 0.688 O60832 M350T Disease 0.812 0.784 0.01 54 0.927 O60832 S121G Disease 0.598 0.223 0.30 0 0.526 O60840 C74R Disease NA 0.707 0.01 67 0.834 O60840 A928D Disease 0.490 0.657 0.01 60 0.759 O60840 F753C Disease 0.991 0.905 0.00 57 0.979 O60840 G150R Disease NA 0.938 0.00 68 0.750 O60840 G261R Disease NA 0.967 0.00 61 0.928 O60840 G369D Disease 0.985 0.861 0.00 49 0.943 O60840 G674D Disease 0.995 0.942 0.00 46 0.956 O60840 I756T Disease 0.986 0.884 0.00 37 0.949 O60840 L860P Disease 0.701 0.824 0.00 57 0.748 O60840 R519Q Disease 0.972 0.584 0.22 27 0.881 O60840 S229P Disease NA 0.694 0.11 60 0.908 O60840 V635I Disease 0.169 0.468 0.62 -7 0.171 O60840 A1259T Polymorphism 0.318 0.181 0.04 -13 0.304 O60840 A1270T Polymorphism 0.318 0.306 0.05 -19 0.201 O60840 C1499R Disease 0.989 0.858 0.00 33 0.930 O60840 G1018R Disease 0.945 0.946 0.00 15 0.914 O60840 L1079P Disease 0.996 0.801 0.00 55 0.980 O60840 L1375H Disease NA 0.540 0.00 43 0.794 O60840 L1508P Disease 0.987 0.896 0.00 63 0.946 O60840 P1500R Disease 0.995 0.740 0.00 31 0.912 O60840 R1060W Disease 0.994 0.777 0.00 58 0.945 O60840 R1930H Polymorphism 0.066 0.097 0.12 -58 0.080 O60841 R360G Polymorphism 0.701 0.266 0.00 40 0.520 O60844 S32G Polymorphism NA 0.085 1.00 -9 0.064 O60844 T162S Polymorphism NA 0.033 0.58 -21 0.010 O60858 S355T Polymorphism NA 0.096 NA 28 0.046 O60879 L426V Polymorphism 0.299 0.607 0.07 45 0.512 O60880 H8D Disease NA 0.951 0.02 68 0.938 O60880 Y7C Disease NA 0.940 0.01 82 0.919 O60880 C42W Disease 0.947 0.918 0.00 54 0.947 O60880 D33Y Disease 0.882 0.883 0.06 49 0.916 O60880 F87S Disease 0.690 0.692 0.01 41 0.775 O60880 G16D Disease NA 0.573 0.00 26 0.709 O60880 G27S Disease NA 0.834 0.01 63 0.899 O60880 G49V Disease 0.366 0.700 0.24 44 0.693 O60880 I84T Disease 0.549 0.749 0.00 33 0.770 O60880 L31P Disease 0.835 0.883 0.00 24 0.870 O60880 Q99P Disease 0.452 0.556 0.30 0 0.443 O60880 R32T Disease 0.737 0.910 0.00 69 0.933 O60880 R55L Disease 0.740 0.982 0.22 53 0.914 O60880 S28R Disease NA 0.819 0.01 25 0.664 O60880 T53I Disease 0.606 0.940 0.04 21 0.814 O60880 T68I Disease 0.589 0.738 0.26 -3 0.753 O60880 Y54C Disease 0.903 0.984 0.11 59 0.946 O60880 P101L Disease 0.829 0.707 0.00 37 0.800 O60880 V102G Disease 0.786 0.844 0.03 49 0.883 O60882 D139N Polymorphism 0.369 0.828 0.01 9 0.567 O60882 I169L Polymorphism 0.304 0.857 0.11 7 0.473 O60882 V275A Polymorphism NA 0.160 0.78 -6 0.135 O60885 P37S Polymorphism NA 0.185 0.05 -17 0.226 O60885 R669H Polymorphism 0.760 0.687 0.01 31 0.759 O60885 S563N Polymorphism 0.170 0.127 0.48 12 0.213 O60885 T598S Polymorphism 0.097 0.148 0.81 -66 0.122 O60890 A45T Polymorphism 0.349 0.294 1.00 -32 0.247 O60890 M693I Polymorphism 0.074 0.132 0.42 22 0.089 O60890 T301M Polymorphism 0.083 0.230 0.21 -2 0.240 O60896 M33L Polymorphism 0.083 0.101 0.12 13 0.109 O60906 R265S Polymorphism 0.186 0.205 0.66 -8 0.053 O60909 G338R Polymorphism 0.989 0.944 0.00 56 0.959 O60909 Q122H Polymorphism 0.197 0.232 0.14 -20 0.232 O60921 D221E Polymorphism 0.153 0.133 0.41 -28 0.088 O60921 S126G Polymorphism 0.564 0.313 0.63 3 0.466 O60925 M67R Polymorphism 0.475 0.920 0.00 57 0.906 O60928 R162W Disease 0.818 0.840 0.00 42 0.877 O60928 T175I Polymorphism 0.095 0.299 0.29 -7 0.269 O60931 D205N Disease 0.851 0.902 0.00 61 0.937 O60931 D305G Disease 0.874 0.973 0.00 51 0.938 O60931 D305Y Disease 0.964 0.973 0.00 58 0.968 O60931 D346N Disease 0.425 0.843 0.25 47 0.661 O60931 G110V Disease 0.196 0.226 0.74 2 0.186 O60931 G169D Disease 0.772 0.963 0.06 61 0.924 O60931 G197R Disease 0.570 0.811 0.11 50 0.823 O60931 G308R Disease 0.955 0.980 0.00 70 0.961 O60931 G339R Disease 0.875 0.939 0.02 65 0.942 O60931 I133F Disease 0.731 0.753 0.02 0 0.685 O60931 K280R Disease 0.714 0.930 0.00 39 0.859 O60931 L158P Disease 0.907 0.993 0.01 55 0.937 O60931 L338P Disease 0.952 0.978 0.00 63 0.954 O60931 N177T Disease 0.711 0.937 0.04 7 0.732 O60931 N288K Disease 0.882 0.951 0.00 57 0.945 O60931 N323K Disease 0.222 0.386 0.94 24 0.384 O60931 P200L Disease 0.720 0.796 0.02 46 0.834 O60931 Q222R Disease 0.681 0.945 0.00 46 0.883 O60931 S139F Disease 0.918 0.977 0.00 40 0.905 O60931 S298N Disease 0.790 0.905 0.07 30 0.712 O60931 W182R Disease 0.721 0.823 0.00 45 0.869 O60934 E185Q Polymorphism 0.152 0.031 0.74 -63 0.025 O60934 K105N Polymorphism 0.425 0.546 0.00 38 0.626 O60934 K408E Polymorphism 0.126 0.145 0.96 30 0.097 O60934 L150F Disease 0.641 0.679 0.00 20 0.721 O60934 L574I Polymorphism 0.269 0.027 0.48 -4 0.057 O60934 N142S Polymorphism 0.162 0.169 1.00 -33 0.096 O60934 P266L Polymorphism 0.655 0.437 0.02 17 0.630 O60934 Q216K Polymorphism 0.146 0.102 1.00 -6 0.080 O60934 R215W Polymorphism 0.849 0.403 0.01 43 0.646 O60934 T497A Polymorphism 0.135 0.055 1.00 -26 0.075 O60934 V210F Polymorphism 0.587 0.245 0.03 -2 0.538 O60938 N247S Disease 0.919 0.905 0.00 73 0.865 O60938 T215K Disease 0.481 0.684 0.01 58 0.690 O60938 V235G Polymorphism 0.380 0.353 0.41 -30 0.122 O60939 R28W Polymorphism 0.713 0.129 0.10 29 0.159 O60942 R594H Polymorphism 0.291 0.202 0.03 -13 0.256 O75015 S65N Polymorphism 0.549 0.166 0.37 -15 0.228 O75015 I106V Polymorphism 0.103 0.075 0.32 3 0.120 O75019 L220P Polymorphism 0.118 0.249 0.22 -31 0.143 O75022 L69W Polymorphism 0.175 0.355 0.28 -47 0.219 O75022 Y400F Polymorphism 0.117 0.354 0.96 13 0.237 O75022 Y400H Polymorphism 0.188 0.460 0.51 2 0.235 O75027 E433K Disease 0.590 0.756 0.35 42 0.706 O75027 F346I Polymorphism 0.780 0.769 0.00 62 0.915 O75027 I400M Disease 0.667 0.706 0.05 29 0.868 O75027 V411L Disease 0.424 0.873 0.21 17 0.655 O75030 N317K Disease 0.930 0.946 0.01 38 0.880 O75030 N385D Disease 0.780 0.876 0.03 56 0.911 O75030 R310K Disease 0.831 0.885 0.15 16 0.881 O75030 S357P Disease 0.920 0.984 0.03 30 0.903 O75030 S405P Disease 0.490 0.397 1.00 -79 0.238 O75051 A267T Polymorphism 0.182 0.116 0.83 -38 0.120 O75051 A805G Polymorphism 0.163 0.236 0.58 3 0.187 O75051 E369G Polymorphism 0.253 0.636 0.14 24 0.489 O75051 A1443T Polymorphism 0.143 0.151 0.86 -26 0.108 O75054 S51P Polymorphism 0.628 0.740 0.04 20 0.822 O75054 Q1073R Polymorphism NA 0.109 0.40 26 0.188 O75056 D303N Polymorphism 0.211 0.253 0.48 -12 0.223 O75056 T329I Polymorphism 0.232 0.091 0.26 12 0.068 O75056 V208I Polymorphism NA 0.035 0.24 7 0.029 O75071 L337P Polymorphism 0.559 0.404 NA 48 0.391 O75072 C250G Disease NA 0.906 0.00 49 0.868 O75072 G125S Polymorphism NA 0.211 0.00 2 0.159 O75072 N446D Polymorphism NA 0.399 0.00 44 0.626 O75072 Q358P Disease NA 0.454 0.20 26 0.529 O75072 R179T Disease NA 0.842 0.00 53 0.880 O75072 R307Q Disease NA 0.932 0.03 69 0.943 O75083 I185V Polymorphism 0.198 0.257 0.31 9 0.172 O75084 G24S Polymorphism NA 0.219 0.41 -45 0.196 O75093 P824L Polymorphism 0.662 0.609 0.06 47 0.824 O75094 G618S Polymorphism NA 0.183 1.00 -20 0.106 O75094 P1064A Polymorphism 0.260 0.212 0.48 34 0.339 O75095 L688P Polymorphism NA 0.522 0.30 -45 0.232 O75095 M115T Polymorphism NA 0.248 0.49 -2 0.199 O75095 S131G Polymorphism NA 0.423 0.38 -9 0.260 O75096 A1203V Polymorphism NA 0.419 0.83 -15 0.027 O75106 R273Q Polymorphism 0.086 0.246 0.57 -20 0.133 O75112 V55I Polymorphism 0.197 0.077 0.23 1 0.148 O75112 D673N Disease 0.268 0.465 0.16 46 0.290 O75112 I345M Disease NA 0.257 0.14 28 0.333 O75112 S189L Disease 0.206 0.119 0.66 22 0.185 O75112 T206I Disease 0.343 0.319 0.03 34 0.459 O75112 V635I Polymorphism 0.117 0.352 0.42 18 0.260 O75116 D601V Polymorphism 0.428 0.294 0.04 -9 0.448 O75116 K1083M Polymorphism 0.654 0.421 0.01 43 0.635 O75127 P356L Polymorphism NA 0.216 0.09 40 0.260 O75127 V620G Polymorphism 0.685 0.440 0.00 12 0.627 O75128 D927N Polymorphism 0.103 0.096 NA -4 0.081 O75128 H919Q Polymorphism 0.198 0.058 NA 17 0.089 O75128 P526L Polymorphism 0.099 0.081 0.12 -23 0.066 O75128 V607I Polymorphism 0.069 0.042 0.74 -31 0.031 O75128 A1015P Polymorphism 0.236 0.139 NA -10 0.102 O75129 V70I Polymorphism NA 0.196 0.00 29 0.288 O75129 V1149I Polymorphism NA 0.058 0.34 -6 0.048 O75131 E252D Polymorphism 0.282 0.377 0.07 -4 0.362 O75131 T412M Polymorphism 0.524 0.452 0.14 -19 0.471 O75140 A641V Polymorphism 0.370 0.172 0.50 25 0.138 O75140 S491T Polymorphism 0.259 0.069 0.93 1 0.079 O75140 S712F Polymorphism 0.616 0.190 0.72 38 0.193 O75146 K404Q Polymorphism 0.147 0.045 0.92 -39 0.052 O75146 K516Q Polymorphism 0.099 0.162 0.57 -30 0.120 O75146 N943S Polymorphism 0.466 0.285 0.61 -14 0.249 O75150 R463H Polymorphism 0.715 0.655 0.02 22 0.697 O75151 T56P Polymorphism 0.475 0.658 0.09 54 0.736 O75152 T640N Polymorphism 0.333 0.252 0.22 37 0.226 O75155 H655R Polymorphism 0.245 0.151 0.67 -7 0.145 O75155 L845F Polymorphism 0.554 0.632 0.20 29 0.523 O75155 P476L Polymorphism 0.278 0.354 0.01 -3 0.405 O75155 Q408R Polymorphism 0.320 0.045 1.00 -13 0.019 O75155 V990I Polymorphism 0.251 0.506 0.39 -22 0.384 O75157 A419T Polymorphism NA 0.060 0.58 -24 0.045 O75161 D3Y Disease NA 0.536 NA 27 0.655 O75161 F91L Disease NA 0.483 NA 42 0.462 O75161 T29M Polymorphism NA 0.099 NA 40 0.086 O75161 A654G Disease NA 0.121 NA 8 0.123 O75161 F991S Disease NA 0.794 NA 35 0.747 O75161 G754R Disease NA 0.445 NA 53 0.645 O75161 H782Q Disease NA 0.172 NA 40 0.185 O75161 L939Q Polymorphism NA 0.295 NA 40 0.385 O75161 P776R Disease NA 0.059 NA 19 0.088 O75161 Q766R Disease NA 0.097 NA 36 0.141 O75161 R342C Disease NA 0.213 NA 49 0.349 O75161 R469W Disease NA 0.114 NA 35 0.115 O75161 R735W Disease NA 0.253 NA 35 0.398 O75161 R848W Polymorphism NA 0.137 NA 41 0.153 O75161 R959Q Polymorphism NA 0.328 NA 44 0.551 O75161 R961H Disease NA 0.163 NA 15 0.193 O75161 T627M Disease NA 0.039 NA 25 0.080 O75161 T946A Disease NA 0.040 NA -29 0.056 O75161 V765I Polymorphism NA 0.079 NA -45 0.114 O75161 A1098T Disease NA 0.097 NA 0 0.081 O75161 Q1287E Disease NA 0.452 NA 12 0.504 O75161 R1192W Disease NA 0.262 NA 35 0.399 O75161 R1284C Disease NA 0.175 NA 36 0.259 O75161 T1225M Disease NA 0.164 NA 34 0.232 O75165 F1487C Polymorphism NA 0.857 NA 21 0.772 O75170 R732K Polymorphism 0.309 0.079 1.00 -50 0.114 O75173 A77T Polymorphism NA 0.230 0.79 -30 0.220 O75173 P552T Polymorphism 0.142 0.786 0.00 55 0.528 O75173 R836K Polymorphism NA 0.279 0.00 -5 0.166 O75173 T564A Polymorphism 0.112 0.371 0.82 -9 0.118 O75185 M165L Polymorphism 0.354 0.307 1.00 0 0.295 O75185 M466L Polymorphism 0.260 0.537 0.03 -9 0.272 O75191 D85E Polymorphism 0.287 0.507 0.42 10 0.440 O75191 D133N Polymorphism 0.264 0.364 0.81 2 0.235 O75191 D139E Polymorphism 0.752 0.821 0.00 65 0.925 O75191 N348D Polymorphism 0.188 0.256 0.87 -19 0.254 O75197 A214T Disease NA 0.482 0.01 25 0.487 O75197 A214V Disease NA 0.705 0.01 39 0.696 O75197 A242T Disease 0.343 0.361 0.01 42 0.519 O75197 D111Y Disease 0.733 0.804 0.01 47 0.810 O75197 G171R Disease 0.811 0.846 0.02 55 0.926 O75197 G171V Disease 0.791 0.755 0.01 45 0.864 O75197 R494Q Disease 0.926 0.746 0.33 35 0.878 O75197 R570Q Disease 0.653 0.414 0.19 25 0.592 O75197 R570W Disease 0.932 0.797 0.02 34 0.826 O75197 T253I Disease 0.616 0.510 0.00 46 0.555 O75197 V667M Polymorphism 0.523 0.138 0.07 -3 0.339 O75197 A1330V Polymorphism NA 0.243 1.00 -3 0.239 O75197 A1525V Polymorphism NA 0.162 0.50 6 0.134 O75197 C1361G Disease NA 0.722 0.00 62 0.962 O75197 E1367K Disease NA 0.663 0.00 64 0.943 O75251 V122M Disease 0.826 0.925 0.00 50 0.913 O75298 R425Q Polymorphism NA 0.073 0.55 -29 0.107 O75306 P20T Polymorphism NA 0.144 0.00 -23 0.176 O75306 P229Q Disease 0.875 0.765 0.03 56 0.912 O75306 P352A Polymorphism 0.752 0.828 0.02 6 0.686 O75306 R228Q Disease 0.728 0.919 0.01 66 0.920 O75306 S413P Disease 0.890 0.914 0.05 41 0.886 O75309 H257Y Polymorphism 0.259 0.179 0.76 48 0.373 O75324 G88S Polymorphism NA 0.178 NA -19 0.061 O75324 V17I Polymorphism NA 0.262 NA 41 0.215 O75325 P7L Polymorphism NA 0.194 0.06 5 0.213 O75325 A19T Polymorphism NA 0.227 0.22 -13 0.259 O75325 L518V Polymorphism 0.082 0.096 0.68 8 0.099 O75325 P692S Polymorphism NA 0.123 0.45 23 0.048 O75326 R207Q Polymorphism 0.381 0.467 0.50 23 0.262 O75326 R460H Polymorphism 0.064 0.491 0.02 35 0.121 O75326 R461C Polymorphism 0.765 0.523 0.05 45 0.709 O75326 S115T Polymorphism NA 0.176 0.49 -21 0.135 O75330 D557H Polymorphism 0.335 0.045 0.04 12 0.060 O75330 N305K Polymorphism 0.154 0.099 0.93 -15 0.054 O75330 R332H Polymorphism 0.176 0.046 0.57 8 0.051 O75333 Q160H Polymorphism 0.275 0.566 0.88 -30 0.323 O75339 A895V Polymorphism 0.373 0.179 0.04 -5 0.226 O75339 I395T Polymorphism 0.097 0.365 0.07 -9 0.193 O75339 D1101N Polymorphism 0.474 0.455 0.00 37 0.603 O75339 V1168A Polymorphism 0.100 0.066 1.00 4 0.016 O75342 H578Q Disease 0.954 0.926 0.00 73 0.953 O75342 L426P Disease 0.928 0.939 0.00 65 0.950 O75343 M128I Polymorphism 0.086 0.081 0.38 -2 0.036 O75343 N316H Polymorphism 0.125 0.209 1.00 -26 0.122 O75352 G73E Disease 0.984 0.938 0.00 68 0.963 O75352 L74S Disease 0.950 0.565 0.01 37 0.781 O75352 A229T Polymorphism 0.290 0.232 0.06 -37 0.287 O75352 G225S Polymorphism 0.293 0.174 0.71 -17 0.135 O75352 L119P Disease 0.851 0.983 0.19 53 0.930 O75354 L138V Polymorphism 0.102 0.395 1.00 -29 0.218 O75354 R157Q Polymorphism 0.112 0.280 0.54 -25 0.167 O75354 S323N Polymorphism 0.631 0.533 0.80 35 0.497 O75355 E440D Polymorphism 0.298 0.520 0.76 -10 0.298 O75360 R73C Disease 0.999 0.925 0.00 76 0.945 O75360 R73H Disease 0.999 0.865 0.00 72 0.943 O75360 A142T Polymorphism 0.125 0.211 0.72 -23 0.140 O75360 F117I Disease 0.418 0.886 0.00 66 0.733 O75360 R120C Disease 0.809 0.936 0.00 77 0.822 O75360 R125W Disease 0.857 0.940 0.00 69 0.923 O75362 V739I Polymorphism 0.064 0.146 NA -17 0.072 O75363 Q472H Polymorphism 0.368 0.102 0.00 30 0.176 O75363 S583P Polymorphism 0.451 0.634 0.00 38 0.732 O75363 V163A Polymorphism NA 0.139 0.37 -4 0.078 O75364 S13N Disease NA 0.092 0.57 3 0.078 O75369 A173V Disease 0.753 0.908 0.00 41 0.872 O75369 E227K Disease 0.779 0.891 0.01 29 0.750 O75369 F161C Disease 0.864 0.866 0.00 58 0.935 O75369 G168S Disease 0.818 0.921 0.00 52 0.923 O75369 G361S Disease 0.420 0.816 0.00 26 0.643 O75369 G363E Disease 0.464 0.731 0.00 46 0.694 O75369 G751R Disease 0.235 0.823 0.03 69 0.808 O75369 L171R Disease 0.856 0.924 0.00 53 0.930 O75369 L234V Disease 0.650 0.396 0.56 19 0.552 O75369 M202V Disease 0.519 0.740 0.02 28 0.805 O75369 S188P Disease 0.608 0.508 0.04 40 0.774 O75369 S235P Disease 0.787 0.755 0.02 72 0.904 O75369 G1586R Disease 0.923 0.935 0.00 65 0.946 O75369 G1691S Disease 0.550 0.682 0.55 24 0.525 O75369 G1834R Disease 0.859 0.767 0.01 66 0.847 O75369 L1431R Disease 0.563 0.916 0.00 51 0.834 O75369 P1603L Disease 0.914 0.783 0.01 50 0.919 O75369 V1592D Disease 0.700 0.694 0.00 1 0.813 O75381 A117S Polymorphism 0.341 0.353 0.00 -2 0.271 O75382 L298R Polymorphism 0.618 0.752 0.02 20 0.599 O75385 P478L Polymorphism 0.298 0.090 0.11 17 0.107 O75385 P714L Polymorphism NA 0.051 0.33 11 0.071 O75387 G238V Polymorphism NA 0.523 0.26 18 0.462 O75387 H443Y Polymorphism NA 0.218 0.34 -7 0.108 O75388 F327L Polymorphism 0.188 0.522 1.00 1 0.359 O75396 R108Q Polymorphism 0.560 0.828 0.03 45 0.859 O75396 W214C Polymorphism 0.731 0.633 0.00 39 0.759 O75409 V68I Polymorphism NA 0.181 0.00 -4 0.367 O75410 E255G Polymorphism 0.248 0.403 0.01 15 0.518 O75410 I243T Polymorphism 0.141 0.245 0.22 -23 0.163 O75410 P187L Polymorphism NA 0.069 0.02 -7 0.093 O75419 V81I Polymorphism 0.154 0.078 1.00 -35 0.092 O75427 V642M Polymorphism NA 0.160 0.01 29 0.292 O75437 A386T Polymorphism 0.557 0.303 0.29 0 0.469 O75437 K537N Polymorphism 0.643 0.197 0.05 30 0.612 O75437 V594I Polymorphism 0.386 0.268 0.11 -42 0.053 O75439 E396D Polymorphism 0.298 0.628 0.08 12 0.448 O75443 Q19R Polymorphism NA 0.073 1.00 -54 0.058 O75443 R371G Polymorphism 0.418 0.154 1.00 12 0.140 O75443 C1057S Disease 0.446 0.889 0.16 39 0.550 O75443 C1619S Disease 0.884 0.882 0.52 56 0.778 O75443 G1824D Disease NA 0.907 0.18 60 0.752 O75443 L1820F Disease NA 0.861 0.12 57 0.747 O75443 S1584T Polymorphism 0.196 0.407 0.61 50 0.288 O75443 Y1870C Disease NA 0.975 0.02 67 0.912 O75444 K297R Disease 0.838 0.730 0.00 34 0.872 O75444 R288P Disease 0.934 0.964 0.01 56 0.954 O75445 C163Y Disease NA 0.317 0.00 38 0.378 O75445 C319Y Disease 0.592 0.972 0.00 60 0.924 O75445 C419F Disease 0.522 0.827 0.00 62 0.905 O75445 C536R Disease 0.515 0.764 0.01 77 0.840 O75445 C575S Disease 0.300 0.808 0.35 63 0.938 O75445 C759F Disease 0.522 0.826 0.00 71 0.908 O75445 D644V Polymorphism 0.322 0.263 0.01 48 0.424 O75445 E284K Disease 0.248 0.374 0.02 55 0.569 O75445 E478D Disease 0.187 0.295 0.12 25 0.286 O75445 F479S Polymorphism 0.115 0.738 0.00 45 0.720 O75445 F595S Polymorphism NA 0.236 0.08 37 0.236 O75445 F739L Disease NA 0.306 0.66 48 0.300 O75445 G268R Disease NA 0.464 0.00 65 0.689 O75445 G516V Disease 0.485 0.833 0.00 61 0.887 O75445 G713R Disease 0.520 0.820 0.00 69 0.883 O75445 H610P Disease 0.497 0.508 0.16 46 0.495 O75445 L280F Disease 0.311 0.353 0.01 49 0.608 O75445 L365F Polymorphism 0.311 0.383 0.12 35 0.236 O75445 L555V Disease 0.194 0.254 0.20 47 0.273 O75445 N346H Disease 0.468 0.172 0.04 52 0.240 O75445 N357T Disease 0.145 0.243 0.14 34 0.279 O75445 P761R Disease 0.475 0.363 0.07 54 0.419 O75445 R303C Disease 0.697 0.218 0.00 51 0.505 O75445 R303S Disease 0.331 0.240 0.04 38 0.374 O75445 R334Q Disease 0.305 0.285 0.03 43 0.357 O75445 R334W Disease 0.767 0.707 0.01 49 0.876 O75445 R464C Disease 0.691 0.727 0.00 59 0.900 O75445 R517T Disease 0.360 0.711 0.03 54 0.680 O75445 S307I Disease 0.415 0.132 0.01 27 0.282 O75445 S391I Disease 0.409 0.760 0.00 48 0.807 O75445 T352I Disease 0.299 0.654 0.01 43 0.701 O75445 T911N Disease 0.200 0.210 0.22 49 0.206 O75445 V218E Disease NA 0.538 0.00 61 0.777 O75445 V230M Disease NA 0.131 0.02 14 0.140 O75445 A2249D Disease NA 0.474 0.06 54 0.703 O75445 A2795S Disease NA 0.781 0.01 28 0.620 O75445 C3251R Disease NA 0.508 NA 66 0.827 O75445 C3267R Disease NA 0.402 NA 63 0.680 O75445 C3282R Disease NA 0.554 NA 67 0.820 O75445 D3144N Polymorphism NA 0.284 0.22 36 0.241 O75445 E3411A Polymorphism NA 0.068 NA -3 0.021 O75445 F4624V Polymorphism NA 0.173 1.00 -9 0.119 O75445 G3895E Disease NA 0.906 0.00 51 0.891 O75445 I1665T Polymorphism NA 0.337 0.30 49 0.198 O75445 I3335M Polymorphism NA 0.101 NA 3 0.085 O75445 L1470R Disease 0.277 0.427 0.02 51 0.613 O75445 L1572F Polymorphism NA 0.839 0.04 44 0.855 O75445 L4795R Disease NA 0.932 0.00 66 0.934 O75445 M3868V Polymorphism NA 0.195 0.12 -7 0.160 O75445 N3199D Polymorphism NA 0.091 NA -54 0.059 O75445 P1059L Disease 0.450 0.231 0.07 46 0.392 O75445 P1212L Disease 0.450 0.911 0.00 48 0.876 O75445 P3504T Disease NA 0.636 0.01 -23 0.540 O75445 P3590L Polymorphism NA 0.732 0.08 37 0.800 O75445 P3893T Polymorphism NA 0.434 0.70 32 0.381 O75445 P4232R Disease NA 0.860 0.01 50 0.716 O75445 P4818L Disease NA 0.449 0.10 35 0.478 O75445 Q4592H Disease NA 0.163 0.07 58 0.308 O75445 R1486K Polymorphism 0.029 0.270 0.79 39 0.169 O75445 R2292H Polymorphism NA 0.321 0.09 -25 0.208 O75445 R2354H Disease NA 0.170 0.10 -34 0.180 O75445 R2875Q Polymorphism NA 0.226 0.51 51 0.397 O75445 R3124G Disease NA 0.601 0.02 43 0.558 O75445 R4115C Disease NA 0.805 0.04 55 0.881 O75445 R4674G Disease NA 0.532 0.24 48 0.710 O75445 S4054I Disease NA 0.706 0.04 55 0.829 O75445 T1515M Disease 0.269 0.069 0.06 -12 0.112 O75445 T2086N Polymorphism NA 0.401 0.25 54 0.601 O75445 T3115A Polymorphism NA 0.090 0.45 -34 0.167 O75445 T3571M Disease NA 0.281 0.03 34 0.421 O75445 T3976M Disease NA 0.299 0.03 51 0.554 O75445 T4337M Disease NA 0.494 0.00 53 0.764 O75445 T4425M Disease NA 0.750 0.02 52 0.859 O75445 T4439I Disease NA 0.677 0.04 44 0.614 O75445 V1833E Disease NA 0.523 0.01 66 0.687 O75445 V2562A Polymorphism NA 0.249 0.50 5 0.213 O75445 W3521R Disease NA 0.972 0.00 65 0.937 O75445 Y1757C Polymorphism NA 0.475 0.18 66 0.726 O75445 Y4487C Disease NA 0.573 0.07 61 0.793 O75448 A204T Polymorphism 0.264 0.095 0.29 -9 0.079 O75459 L75P Polymorphism NA 0.374 0.31 4 0.250 O75460 V418M Polymorphism NA 0.052 0.05 -1 0.077 O75462 R81H Disease NA 0.172 0.38 33 0.287 O75462 W76G Disease NA 0.860 0.00 48 0.844 O75462 L374R Disease NA 0.328 0.73 54 0.547 O75462 R176K Polymorphism 0.234 0.274 0.58 11 0.270 O75469 A12T Polymorphism NA 0.089 0.69 -23 0.078 O75469 E18K Polymorphism NA 0.261 0.51 17 0.344 O75469 P27S Polymorphism NA 0.417 0.44 -30 0.267 O75469 R98C Polymorphism 0.999 0.918 0.00 75 0.952 O75469 R122Q Polymorphism 0.325 0.486 0.25 51 0.511 O75473 H383R Polymorphism 0.245 0.290 0.61 26 0.346 O75473 V666A Polymorphism 0.401 0.410 0.21 12 0.321 O75478 M115V Polymorphism 0.289 0.097 0.58 9 0.151 O75486 D324A Polymorphism 0.223 0.544 0.37 12 0.425 O75487 A442V Polymorphism NA 0.208 0.23 10 0.347 O75487 E391D Polymorphism 0.230 0.187 0.50 -38 0.226 O75496 N15H Polymorphism 0.300 0.063 0.00 3 0.174 O75496 R54W Polymorphism 0.229 0.045 0.05 -25 0.036 O75496 S60P Polymorphism 0.720 0.174 0.00 41 0.150 O75496 T203M Polymorphism 0.378 0.086 0.00 32 0.167 O75503 R63H Disease 0.462 0.532 0.00 54 0.723 O75503 R63P Disease 0.466 0.720 0.00 51 0.827 O75503 D230N Disease 0.478 0.541 0.31 38 0.709 O75503 E219A Polymorphism 0.063 0.052 0.72 13 0.035 O75503 K319R Polymorphism 0.081 0.067 0.79 -32 0.039 O75503 W330C Disease 0.642 0.827 0.01 53 0.883 O75503 Y209D Disease 0.488 0.707 0.00 60 0.846 O75521 M47I Polymorphism NA 0.150 0.04 -16 0.184 O75526 L15F Polymorphism 0.321 0.857 0.03 55 0.900 O75526 Y308C Polymorphism 0.735 0.242 0.04 48 0.475 O75558 E31Q Polymorphism 0.112 0.165 0.31 -26 0.100 O75558 R49Q Polymorphism 0.092 0.055 0.54 -22 0.066 O75563 A202S Polymorphism 0.104 0.095 0.79 -52 0.092 O75563 S253T Polymorphism 0.256 0.127 0.43 16 0.143 O75569 P222L Disease 0.363 0.053 0.33 17 0.072 O75570 N2S Polymorphism 0.112 0.238 1.00 -18 0.106 O75570 L324V Polymorphism 0.234 0.563 0.11 -12 0.284 O75578 R381Q Polymorphism 0.306 0.593 0.21 27 0.433 O75578 R691H Polymorphism 0.471 0.456 0.30 14 0.427 O75578 R725Q Polymorphism 0.306 0.736 0.17 24 0.514 O75581 R611C Disease 0.702 0.523 0.02 37 0.759 O75581 R1401H Polymorphism NA 0.215 0.05 -9 0.235 O75582 D554N Polymorphism NA 0.325 0.37 23 0.397 O75582 P574L Polymorphism NA 0.095 0.41 -7 0.155 O75582 Y599C Polymorphism NA 0.841 0.01 68 0.724 O75592 A1881S Polymorphism 0.206 0.190 0.21 19 0.182 O75596 Q197K Polymorphism NA 0.123 0.00 2 0.199 O75600 R39C Polymorphism 0.786 0.847 0.00 46 0.876 O75602 Q216R Polymorphism 0.114 0.301 0.55 3 0.281 O75603 G63S Disease 0.326 0.784 0.75 37 0.517 O75603 R47L Disease 0.839 0.935 0.03 60 0.948 O75603 A117V Polymorphism 0.486 0.104 0.29 10 0.168 O75604 N383S Polymorphism 0.105 0.085 0.70 -8 0.103 O75610 D322A Polymorphism 0.064 0.042 0.49 2 0.037 O75631 Q91L Polymorphism NA 0.177 0.19 33 0.179 O75631 A154P Polymorphism 0.074 0.129 0.32 39 0.111 O75631 G202D Disease 0.192 0.721 0.00 38 0.688 O75631 P273L Disease 0.097 0.239 0.00 25 0.128 O75635 R266Q Polymorphism 0.154 0.219 0.64 -12 0.152 O75638 P99A Polymorphism NA 0.201 0.04 -8 0.267 O75648 E148K Polymorphism NA 0.735 0.71 5 0.493 O75648 R398C Polymorphism 0.281 0.208 0.08 37 0.313 O75665 A79T Disease NA 0.399 NA 7 0.499 O75665 S74F Disease NA 0.244 NA 23 0.387 O75665 G138S Disease NA 0.305 0.17 -4 0.198 O75665 S435R Disease NA 0.185 0.46 7 0.243 O75676 S758A Polymorphism NA 0.061 1.00 6 0.033 O75677 W94R Polymorphism 0.203 0.708 0.36 40 0.442 O75679 M83T Polymorphism 0.115 0.187 0.57 -3 0.172 O75683 N201H Polymorphism 0.551 0.194 0.05 25 0.358 O75683 R163W Polymorphism NA 0.171 0.01 31 0.195 O75683 T311M Polymorphism 0.532 0.108 0.10 -26 0.156 O75691 S502C Polymorphism 0.774 0.314 NA 14 0.475 O75691 E2612Q Polymorphism NA 0.148 0.17 27 0.128 O75695 C67Y Disease 0.849 0.604 0.01 66 0.920 O75695 C86Y Disease 0.849 0.839 0.00 61 0.926 O75695 P95L Disease 0.774 0.851 0.01 41 0.864 O75695 C108G Disease 0.517 0.857 0.00 51 0.874 O75695 D338Y Polymorphism 0.508 0.488 0.00 51 0.631 O75695 E138G Disease 0.602 0.829 0.11 53 0.874 O75695 K144R Polymorphism 0.212 0.094 0.18 -13 0.109 O75695 L188P Disease 0.791 0.874 0.00 21 0.684 O75695 L253R Disease 0.763 0.500 0.01 15 0.663 O75695 R118C Disease 0.882 0.942 0.01 70 0.956 O75695 R118H Disease 0.739 0.891 0.02 66 0.916 O75695 R118L Disease 0.673 0.958 0.03 65 0.941 O75712 C86S Disease 0.691 0.510 0.28 -6 0.641 O75712 G12D Disease 0.913 0.886 0.16 3 0.872 O75712 G12R Disease 0.935 0.919 0.03 15 0.877 O75712 R42P Disease 0.487 0.732 0.22 0 0.436 O75712 E183K Disease 0.997 0.971 0.00 53 0.953 O75712 F137L Disease 0.444 0.713 0.04 -32 0.474 O75712 I141V Disease 0.151 0.215 0.28 -47 0.153 O75712 V200I Polymorphism 0.066 0.251 0.39 -20 0.195 O75716 R266W Polymorphism 0.435 0.846 0.00 24 0.849 O75718 E137D Polymorphism 0.092 0.162 0.62 -13 0.124 O75718 L261V Polymorphism 0.246 0.184 0.15 -11 0.260 O75747 A261E Polymorphism NA 0.167 0.06 -4 0.262 O75751 T44M Polymorphism NA 0.095 0.05 -22 0.153 O75752 D126N Polymorphism 0.361 0.220 0.56 -7 0.254 O75762 R58T Polymorphism NA 0.335 0.59 -4 0.260 O75762 E179K Polymorphism 0.153 0.244 0.07 36 0.273 O75771 R24S Polymorphism NA 0.206 0.66 14 0.354 O75771 A225T Polymorphism 0.359 0.250 0.42 3 0.276 O75771 E233G Polymorphism 0.404 0.111 0.41 13 0.260 O75771 R165Q Polymorphism 0.150 0.049 0.62 -11 0.061 O75781 T107A Polymorphism 0.316 0.276 0.92 -35 0.216 O75791 L319F Polymorphism NA 0.689 0.38 15 0.686 O75792 G37S Disease NA 0.878 0.00 54 0.901 O75792 A258G Polymorphism 0.378 0.086 0.25 -21 0.156 O75792 L202S Polymorphism 0.514 0.465 0.73 10 0.500 O75807 A32T Polymorphism 0.081 0.165 0.11 44 0.140 O75807 R31H Polymorphism 0.768 0.215 0.02 59 0.493 O75807 A381V Polymorphism 0.327 0.046 0.18 -37 0.036 O75807 R476S Polymorphism 0.075 0.086 0.97 23 0.051 O75807 T597A Polymorphism 0.062 0.027 0.98 -2 0.060 O75807 V199A Polymorphism 0.294 0.171 0.25 15 0.049 O75815 E464G Polymorphism 0.100 0.050 1.00 7 0.020 O75822 A141T Polymorphism 0.173 0.087 1.00 -55 0.038 O75828 V93I Polymorphism 0.138 0.245 0.89 -39 0.235 O75828 M235L Polymorphism 0.277 0.838 0.68 3 0.471 O75829 F116L Polymorphism 0.723 0.797 0.02 50 0.910 O75829 V175I Polymorphism 0.294 0.083 0.33 19 0.076 O75843 S377F Polymorphism 0.622 0.597 0.02 23 0.763 O75844 W340R Disease 0.971 0.896 0.01 59 0.940 O75845 R29Q Disease 0.566 0.852 0.03 60 0.854 O75845 Y46S Disease 0.743 0.925 0.00 44 0.867 O75845 G211D Disease 0.678 0.894 0.10 63 0.915 O75871 H29D Polymorphism 0.181 0.360 0.14 55 0.213 O75874 V178I Polymorphism 0.277 0.583 0.70 12 0.384 O75880 P58S Polymorphism NA 0.240 0.40 -21 0.331 O75880 P174L Disease 0.952 0.875 0.57 46 0.886 O75881 G57R Disease 0.987 0.937 0.00 79 0.956 O75881 F216S Disease 0.209 0.407 0.29 51 0.429 O75881 R417H Disease 0.983 0.917 0.00 54 0.930 O75881 S363F Disease 0.410 0.166 0.05 -21 0.196 O75882 D303A Polymorphism 0.128 0.141 0.12 45 0.205 O75882 I426T Polymorphism 0.480 0.331 0.10 -6 0.285 O75888 N96S Polymorphism NA 0.087 0.85 -43 0.067 O75891 A436T Polymorphism NA 0.691 0.03 8 0.511 O75891 A436V Polymorphism NA 0.637 0.02 9 0.607 O75891 E803K Polymorphism 0.836 0.956 0.02 56 0.935 O75891 I812V Polymorphism 0.205 0.032 0.49 -15 0.121 O75891 L254P Polymorphism NA 0.259 0.18 -6 0.190 O75891 S448N Polymorphism NA 0.404 0.08 -34 0.413 O75891 S481G Polymorphism 0.538 0.364 0.07 19 0.607 O75897 D5E Polymorphism 0.031 0.139 1.00 -16 0.033 O75899 T869A Polymorphism 0.179 0.092 0.00 -49 0.042 O75900 F91L Polymorphism 0.046 0.319 0.66 0 0.300 O75914 R67C Disease NA 0.654 0.01 50 0.703 O75914 A380E Disease 0.846 0.789 0.10 41 0.854 O75916 W299R Disease 0.999 0.941 0.00 70 0.950 O75923 A84V Polymorphism NA 0.328 1.00 42 0.243 O75923 V67D Disease NA 0.441 0.00 55 0.650 O75923 W52R Disease NA 0.438 0.00 62 0.669 O75923 A170E Disease NA 0.147 0.72 14 0.121 O75923 C456W Disease 0.966 0.915 0.01 59 0.954 O75923 D390N Polymorphism 0.427 0.647 0.25 54 0.624 O75923 D625Y Disease 0.808 0.979 0.00 52 0.846 O75923 E389Q Disease 0.458 0.885 0.03 47 0.811 O75923 G155R Disease NA 0.192 0.10 46 0.328 O75923 G234E Disease 0.877 0.867 0.00 52 0.922 O75923 G299E Disease 0.950 0.946 0.00 64 0.951 O75923 G299R Disease 0.961 0.932 0.00 57 0.957 O75923 G299W Disease 0.987 0.961 0.00 62 0.957 O75923 G426R Disease 0.927 0.879 0.01 55 0.931 O75923 G426V Disease 0.920 0.877 0.00 52 0.926 O75923 G519R Disease 0.910 0.958 0.00 60 0.943 O75923 G618R Disease 0.759 0.937 0.00 64 0.942 O75923 G621R Disease 0.759 0.942 0.00 56 0.839 O75923 I284T Disease 0.396 0.585 0.17 25 0.480 O75923 I834V Polymorphism 0.120 0.108 0.09 2 0.131 O75923 L189V Polymorphism 0.092 0.173 0.17 22 0.091 O75923 P731R Disease 0.398 0.351 0.22 30 0.436 O75923 P791R Disease 0.908 0.911 0.00 65 0.941 O75923 R555W Disease 0.891 0.975 0.00 58 0.944 O75923 R959W Disease 0.894 0.908 0.00 62 0.945 O75923 V374L Disease 0.156 0.588 0.18 39 0.261 O75923 W930C Disease 0.952 0.741 0.00 59 0.937 O75923 W999C Disease 0.806 0.786 0.00 59 0.928 O75923 A1072P Polymorphism 0.571 0.659 0.20 15 0.737 O75923 C1361R Disease 0.761 0.889 0.01 47 0.881 O75923 C1942G Disease 0.834 0.939 0.00 49 0.923 O75923 D1837N Disease 0.855 0.944 0.00 58 0.943 O75923 E1335K Disease 0.466 0.954 0.01 48 0.838 O75923 E1734G Disease 0.542 0.873 0.04 27 0.667 O75923 G1543D Disease 0.904 0.926 0.00 20 0.908 O75923 G1679E Disease 0.944 0.958 0.00 52 0.940 O75923 G1842D Disease 0.666 0.888 0.00 53 0.898 O75923 H1857R Disease 0.950 0.951 0.00 57 0.952 O75923 I1208M Disease 0.399 0.433 0.02 49 0.535 O75923 I1298V Disease 0.127 0.044 0.31 -19 0.090 O75923 I1325V Polymorphism 0.113 0.571 0.02 29 0.345 O75923 K1526T Disease 0.561 0.427 0.04 -1 0.544 O75923 L1228P Disease 0.803 0.953 0.00 38 0.875 O75923 L1341P Disease 0.798 0.978 0.00 13 0.870 O75923 L1922P Disease 0.953 0.951 0.00 42 0.912 O75923 P1029L Disease 0.314 0.200 0.01 -11 0.318 O75923 P1970S Disease 0.883 0.836 0.00 29 0.891 O75923 P2068L Disease 0.951 0.880 0.00 52 0.930 O75923 R1022Q Disease 0.152 0.148 0.18 -7 0.193 O75923 R1038Q Disease 0.555 0.744 0.01 43 0.822 O75923 R1041C Disease 0.868 0.765 0.13 57 0.811 O75923 R1046H Disease 0.714 0.724 0.01 3 0.813 O75923 R1693Q Disease 0.490 0.954 0.00 50 0.883 O75923 R1693W Disease 0.878 0.966 0.00 51 0.931 O75923 R1768W Disease 0.984 0.958 0.00 63 0.954 O75923 R2000Q Disease 0.451 0.566 0.07 6 0.483 O75923 R2042C Disease 0.813 0.778 0.01 38 0.851 O75923 T1662R Disease 0.948 0.940 0.00 55 0.950 O75923 Y1505C Disease 0.961 0.879 0.00 59 0.945 O75952 T74M Polymorphism NA 0.076 0.04 10 0.130 O75952 I186V Polymorphism NA 0.050 1.00 -17 0.028 O75962 S291T Polymorphism 0.260 0.129 0.62 21 0.141 O75962 A1613T Polymorphism NA 0.124 0.68 -20 0.128 O75962 H1690R Polymorphism NA 0.109 0.17 -22 0.188 O75969 I500T Polymorphism 0.129 0.105 0.26 18 0.029 O75969 S700F Polymorphism 0.528 0.069 0.05 18 0.077 O75969 S700P Polymorphism 0.435 0.130 0.13 12 0.128 O75970 E702K Polymorphism 0.643 0.799 0.18 20 0.694 O75970 E702V Polymorphism 0.811 0.743 0.00 44 0.737 O75970 L351F Polymorphism 0.560 0.431 0.48 30 0.590 O75976 K36E Polymorphism NA 0.129 0.46 25 0.097 O75976 T899I Polymorphism 0.209 0.114 0.20 -14 0.215 O76001 R226Q Polymorphism 0.255 0.370 0.49 0 0.248 O76001 V228I Polymorphism 0.512 0.067 0.58 -18 0.178 O76002 A111T Polymorphism 0.514 0.112 1.00 -32 0.114 O76002 A146V Polymorphism 0.275 0.605 0.11 -32 0.414 O76003 P123S Polymorphism 0.111 0.236 0.12 -21 0.214 O76013 A119V Polymorphism 0.748 0.260 0.05 -12 0.618 O76013 R179Q Polymorphism 0.876 0.703 0.01 24 0.844 O76014 G13C Polymorphism NA 0.399 0.09 30 0.261 O76014 S73C Polymorphism 0.268 0.389 0.35 -31 0.284 O76014 A217V Polymorphism 0.250 0.632 0.01 0 0.452 O76014 P434S Polymorphism 0.162 0.237 0.78 -28 0.208 O76024 A58V Disease 0.239 0.078 NA 31 0.055 O76024 A126T Disease 0.420 0.403 NA 20 0.483 O76024 A133T Disease 0.299 0.639 NA 45 0.497 O76024 A326V Polymorphism 0.409 0.299 NA 23 0.384 O76024 A602V Polymorphism 0.104 0.056 NA -35 0.066 O76024 A716T Disease 0.328 0.194 NA 25 0.285 O76024 C690R Disease 0.391 0.951 NA 70 0.937 O76024 E169K Disease 0.466 0.208 NA 41 0.376 O76024 G437R Disease 0.244 0.221 NA 32 0.310 O76024 G674R Polymorphism 0.609 0.378 NA 59 0.697 O76024 G695V Disease 0.115 0.909 NA 56 0.864 O76024 G736S Disease 0.313 0.790 NA 51 0.836 O76024 G780R Disease 0.521 0.374 NA 46 0.467 O76024 G831D Disease 0.555 0.684 NA 63 0.713 O76024 I296S Disease 0.402 0.523 NA 25 0.693 O76024 K193Q Polymorphism 0.304 0.269 NA 25 0.335 O76024 K634T Disease 0.477 0.198 NA 40 0.330 O76024 L829P Disease 0.501 0.849 NA 69 0.902 O76024 P292S Disease 0.255 0.581 NA 46 0.700 O76024 P504L Disease 0.709 0.756 NA 38 0.836 O76024 P724L Disease 0.546 0.766 NA 23 0.810 O76024 P885L Disease 0.546 0.567 NA 33 0.758 O76024 R456H Polymorphism 0.677 0.348 NA 48 0.592 O76024 R457S Disease 0.562 0.445 NA 49 0.493 O76024 R611H Polymorphism 0.506 0.473 NA 39 0.498 O76024 R629W Disease 0.877 0.305 NA 45 0.482 O76024 R818C Disease 0.680 0.165 NA 47 0.248 O76024 S443I Disease 0.258 0.382 NA 30 0.436 O76024 T699M Disease 0.568 0.565 NA 41 0.745 O76024 V779M Disease 0.659 0.288 NA -2 0.402 O76024 W700C Disease 0.602 0.949 NA 56 0.911 O76024 Y110N Disease 0.484 0.486 NA 50 0.693 O76024 Y669C Disease 0.672 0.901 NA 65 0.910 O76027 A119T Polymorphism 0.418 0.745 0.01 46 0.830 O76027 R225Q Polymorphism 0.505 0.900 0.00 60 0.812 O76027 T114A Polymorphism 0.071 0.454 0.25 -27 0.127 O76038 A216V Polymorphism 0.429 0.451 0.50 -13 0.417 O76039 A40V Disease 0.993 0.903 0.00 37 0.936 O76039 I72N Disease 0.622 0.896 0.00 43 0.875 O76039 I72T Disease 0.397 0.703 0.00 40 0.742 O76039 C152F Disease 0.623 0.848 0.00 45 0.828 O76039 C291Y Disease NA 0.652 0.00 37 0.775 O76039 H127R Disease 0.998 0.887 0.00 51 0.922 O76039 L220P Disease 0.920 0.891 0.00 47 0.896 O76039 N399T Disease NA 0.195 0.04 12 0.200 O76039 P180L Disease 0.914 0.876 0.00 32 0.831 O76039 Q791P Polymorphism NA 0.249 NA 17 0.231 O76039 R175S Disease 0.836 0.506 0.00 51 0.877 O76039 R178P Disease 0.898 0.932 0.00 48 0.865 O76039 R923C Polymorphism NA 0.226 NA 42 0.077 O76039 T288I Disease NA 0.232 0.02 25 0.263 O76039 T734A Polymorphism NA 0.090 NA 10 0.080 O76039 V718M Disease NA 0.143 NA 31 0.151 O76039 V793A Disease NA 0.140 NA 41 0.160 O76039 E1023G Polymorphism NA 0.276 NA 39 0.078 O76041 A219D Polymorphism 0.451 0.211 0.00 49 0.468 O76041 D378H Polymorphism 0.524 0.265 0.00 26 0.607 O76041 M351V Polymorphism 0.105 0.218 0.01 40 0.274 O76041 N654K Polymorphism 0.225 0.266 0.04 21 0.226 O76041 Q187H Polymorphism 0.483 0.218 0.00 3 0.341 O76041 T728A Polymorphism 0.116 0.242 0.31 -16 0.157 O76054 R11K Polymorphism NA 0.203 1.00 -24 0.150 O76062 T299I Polymorphism 0.288 0.323 0.61 -27 0.193 O76070 E110V Polymorphism 0.147 0.022 0.08 16 0.053 O76074 S181A Polymorphism NA 0.667 0.71 -34 0.412 O76075 K277R Polymorphism 0.107 0.092 0.68 -14 0.063 O76082 E452K Disease 0.996 0.864 0.00 84 0.907 O76082 F508L Polymorphism 0.375 0.500 1.00 -13 0.411 O76082 M179L Disease 0.159 0.400 1.00 -20 0.145 O76082 P478L Disease 0.992 0.939 0.68 38 0.911 O76082 P549S Polymorphism NA 0.350 0.90 -22 0.402 O76082 R169Q Disease 0.981 0.939 0.00 77 0.944 O76082 S467C Disease 0.945 0.834 0.09 35 0.889 O76082 V446F Disease 0.531 0.820 0.06 16 0.519 O76082 V481F Polymorphism 0.459 0.667 0.09 -21 0.486 O76082 V481I Polymorphism 0.159 0.092 0.19 -30 0.151 O76082 W283C Disease 0.918 0.891 0.00 73 0.906 O76082 W283R Disease 0.839 0.881 0.00 75 0.906 O76082 Y211C Disease 0.896 0.912 0.18 33 0.795 O76090 I3T Disease NA 0.505 0.01 5 0.486 O76090 T6P Disease NA 0.903 0.21 33 0.834 O76090 T6R Disease NA 0.806 0.37 44 0.814 O76090 V9A Disease 0.926 0.748 0.01 53 0.929 O76090 V9M Disease 0.700 0.914 0.01 61 0.918 O76090 A10T Disease 0.539 0.859 0.08 41 0.824 O76090 A10V Disease 0.814 0.765 0.05 41 0.854 O76090 F17C Disease 0.854 0.941 0.06 59 0.924 O76090 F80L Disease 0.910 0.910 0.02 30 0.874 O76090 G26R Disease 0.985 0.941 0.00 49 0.934 O76090 I73N Disease 0.269 0.239 0.35 -40 0.289 O76090 K30R Disease 0.724 0.872 0.15 7 0.654 O76090 L21V Disease 0.883 0.852 0.02 26 0.850 O76090 L41P Disease 0.821 0.695 0.15 17 0.788 O76090 L82V Disease 0.958 0.885 0.00 44 0.910 O76090 N11I Disease 0.468 0.760 0.07 17 0.767 O76090 N99K Disease 0.842 0.736 0.35 32 0.848 O76090 Q58L Disease 0.779 0.687 0.33 17 0.696 O76090 Q96H Disease 0.907 0.927 0.10 35 0.891 O76090 R13H Disease 0.570 0.508 0.19 20 0.492 O76090 R25Q Disease 0.873 0.821 0.03 53 0.900 O76090 R25W Disease 0.988 0.872 0.00 53 0.949 O76090 R47H Disease 0.694 0.245 0.54 -5 0.466 O76090 R92C Disease 0.992 0.971 0.00 67 0.956 O76090 R92H Disease 0.967 0.944 0.00 67 0.956 O76090 R92S Disease 0.964 0.964 0.01 57 0.956 O76090 S16F Disease 0.791 0.524 0.07 34 0.754 O76090 S27R Disease 0.978 0.979 0.00 58 0.956 O76090 T91I Disease 0.696 0.527 0.19 -26 0.692 O76090 V86M Disease 0.956 0.960 0.01 46 0.911 O76090 V89A Disease 0.933 0.780 0.01 30 0.833 O76090 W24C Disease 0.886 0.933 0.06 62 0.943 O76090 W93C Disease 0.993 0.936 0.00 60 0.957 O76090 Y29H Disease 0.916 0.846 0.00 43 0.882 O76090 Y85H Disease 0.931 0.914 0.00 62 0.944 O76090 A146K Disease 0.290 0.569 1.00 -19 0.349 O76090 A195V Disease 0.798 0.908 0.06 -2 0.715 O76090 A243T Disease 0.922 0.723 0.00 33 0.873 O76090 A243V Disease 0.696 0.728 0.00 34 0.692 O76090 C221W Disease 0.949 0.950 0.02 62 0.941 O76090 D104E Disease 0.417 0.784 0.52 4 0.471 O76090 D104H Disease 0.964 0.944 0.00 54 0.949 O76090 D301E Disease 0.972 0.853 0.00 29 0.928 O76090 D301N Disease 0.982 0.907 0.00 38 0.944 O76090 D302G Disease 0.945 0.978 0.01 40 0.893 O76090 D302H Disease 0.970 0.953 0.00 44 0.930 O76090 D302V Disease 0.981 0.955 0.00 41 0.932 O76090 D303E Disease 0.733 0.859 0.08 5 0.688 O76090 D312N Disease 0.931 0.939 0.00 39 0.888 O76090 E300D Disease 0.805 0.791 0.06 -24 0.695 O76090 E300K Disease 0.907 0.871 0.03 32 0.877 O76090 E306D Disease 0.807 0.872 0.06 -2 0.690 O76090 E306G Disease 0.957 0.950 0.00 36 0.908 O76090 E578V Polymorphism 0.117 0.289 0.05 14 0.204 O76090 F113L Disease 0.324 0.129 0.45 -26 0.123 O76090 F276L Disease 0.453 0.629 0.87 -10 0.424 O76090 F298S Disease 0.972 0.962 0.00 30 0.938 O76090 F305S Disease 0.875 0.970 0.00 35 0.875 O76090 G135S Disease 0.565 0.166 1.00 -63 0.077 O76090 G299A Disease 0.986 0.697 0.00 29 0.902 O76090 G299E Disease 0.993 0.802 0.00 38 0.915 O76090 I201T Disease 0.891 0.860 0.04 44 0.878 O76090 I295T Disease 0.956 0.839 0.01 21 0.883 O76090 I310T Disease 0.882 0.428 0.01 22 0.658 O76090 L100R Disease 0.975 0.912 0.00 57 0.938 O76090 L140R Disease 0.932 0.941 0.04 46 0.898 O76090 L207I Disease 0.596 0.653 0.14 -20 0.595 O76090 L224M Disease 0.913 0.906 0.02 25 0.878 O76090 L224P Disease 0.988 0.990 0.00 61 0.938 O76090 L294V Disease 0.900 0.837 0.01 16 0.799 O76090 L567F Polymorphism 0.489 0.124 0.04 19 0.178 O76090 M325T Disease 0.663 0.743 0.58 12 0.706 O76090 N133K Disease 0.630 0.805 0.92 23 0.811 O76090 N296H Disease 0.966 0.897 0.01 47 0.911 O76090 N296S Disease 0.911 0.866 0.02 23 0.846 O76090 N308S Disease 0.880 0.918 0.05 33 0.830 O76090 P101T Disease 0.828 0.829 0.27 44 0.872 O76090 P152A Disease 0.820 0.764 0.12 39 0.858 O76090 P297A Disease 0.989 0.766 0.00 43 0.917 O76090 P297S Disease 0.991 0.858 0.00 34 0.932 O76090 Q293K Disease 0.598 0.702 0.93 -21 0.741 O76090 R141H Disease 0.952 0.864 0.00 58 0.941 O76090 R218C Disease 0.988 0.953 0.00 64 0.949 O76090 R218H Disease 0.867 0.905 0.01 52 0.906 O76090 R218Q Disease 0.763 0.931 0.10 58 0.911 O76090 R218S Disease 0.923 0.934 0.01 56 0.941 O76090 S209N Disease 0.517 0.300 0.51 -12 0.482 O76090 S231R Disease 0.820 0.963 0.04 48 0.879 O76090 T237R Disease 0.970 0.946 0.09 48 0.919 O76090 T241N Disease 0.744 0.806 0.26 -14 0.714 O76090 T307A Disease 0.686 0.445 0.46 -10 0.542 O76090 T307I Disease 0.652 0.494 0.49 -40 0.513 O76090 V235L Disease 0.807 0.915 0.07 27 0.853 O76090 V235M Disease 0.627 0.909 0.16 -2 0.597 O76090 V239M Disease 0.945 0.877 0.01 34 0.880 O76090 V242M Disease 0.469 0.268 0.10 0 0.366 O76090 V311G Disease 0.936 0.839 0.00 23 0.890 O76090 V317M Disease 0.489 0.905 0.22 41 0.655 O76090 W102R Disease 0.970 0.898 0.05 66 0.947 O76090 Y227C Disease 0.876 0.950 0.06 64 0.925 O76090 Y227N Disease 0.957 0.946 0.02 61 0.947 O76090 Y236C Disease 0.995 0.925 0.00 65 0.951 O76099 E171K Polymorphism 0.098 0.442 0.23 18 0.146 O76100 Q183E Polymorphism 0.240 0.686 0.25 7 0.416 O77932 D63E Polymorphism NA 0.736 0.06 38 0.697 O77932 S28T Polymorphism NA 0.203 0.73 -40 0.153 O77932 H261Q Polymorphism 0.235 0.153 0.50 16 0.134 O94759 V166I Polymorphism 0.445 0.111 0.42 -26 0.237 O94759 R1199W Polymorphism 0.888 0.715 0.01 38 0.830 O94759 T1347M Polymorphism 0.429 0.315 NA 42 0.459 O94761 E71G Polymorphism NA 0.096 NA 31 0.104 O94761 P92S Polymorphism NA 0.089 NA -15 0.082 O94761 Q54R Polymorphism NA 0.150 NA 32 0.143 O94761 A273T Polymorphism NA 0.135 0.00 29 0.145 O94761 E267D Polymorphism NA 0.073 0.01 29 0.121 O94761 E301K Polymorphism NA 0.180 0.00 38 0.178 O94761 P591L Polymorphism 0.296 0.521 0.01 7 0.331 O94761 P964T Polymorphism 0.377 0.395 NA 40 0.576 O94761 R522C Polymorphism NA 0.337 0.00 48 0.625 O94761 R522H Polymorphism NA 0.160 0.04 8 0.215 O94761 S523T Polymorphism NA 0.110 0.07 -18 0.192 O94761 G1105S Polymorphism 0.132 0.077 NA -27 0.020 O94761 L1043P Polymorphism 0.808 0.872 NA 30 0.850 O94761 R1004W Polymorphism 0.837 0.269 NA 30 0.566 O94761 R1021W Disease 0.830 0.175 NA -7 0.269 O94762 D480G Polymorphism 0.086 0.327 0.00 -1 0.062 O94762 S628N Polymorphism 0.274 0.074 NA 8 0.106 O94768 S320F Polymorphism 0.288 0.146 0.03 34 0.263 O94769 Q56P Polymorphism NA 0.124 0.00 15 0.052 O94777 T76S Polymorphism NA 0.055 1.00 -9 0.011 O94778 A260P Polymorphism NA 0.206 0.11 -19 0.300 O94779 N81S Polymorphism NA 0.163 0.57 -1 0.134 O94779 S23A Polymorphism NA 0.060 1.00 21 0.030 O94779 I530V Polymorphism 0.114 0.696 0.64 3 0.132 O94779 M1094V Polymorphism NA 0.088 1.00 -53 0.064 O94779 S1079T Polymorphism NA 0.130 0.78 -70 0.149 O94788 E50G Polymorphism NA 0.174 0.34 -4 0.255 O94788 A110V Polymorphism 0.819 0.717 0.01 26 0.771 O94788 E436K Polymorphism 0.170 0.647 1.00 -45 0.188 O94804 C947Y Polymorphism NA 0.619 0.00 29 0.516 O94804 K277E Disease 0.356 0.838 0.04 34 0.730 O94804 M710T Polymorphism NA 0.385 0.07 34 0.543 O94804 N467S Polymorphism NA 0.110 0.29 -2 0.181 O94804 P480L Polymorphism NA 0.057 0.10 23 0.112 O94804 P520L Polymorphism NA 0.160 0.10 22 0.283 O94804 R268C Polymorphism 0.660 0.323 0.01 19 0.607 O94804 R322W Polymorphism 0.675 0.664 0.02 44 0.789 O94804 S853L Polymorphism NA 0.162 0.01 -1 0.268 O94804 S905T Polymorphism NA 0.090 0.03 7 0.168 O94804 S942N Polymorphism NA 0.187 0.01 -1 0.239 O94804 T336I Polymorphism 0.227 0.135 0.20 10 0.205 O94806 N42D Polymorphism NA 0.116 0.07 39 0.077 O94806 P225S Polymorphism 0.205 0.103 0.49 -18 0.076 O94806 Q546R Polymorphism 0.033 0.098 1.00 18 0.123 O94808 I471V Polymorphism 0.356 0.354 0.13 13 0.370 O94827 F703S Disease 0.523 0.966 0.03 39 0.825 O94830 T186M Polymorphism 0.330 0.153 0.03 -36 0.255 O94832 P765S Polymorphism 0.432 0.479 0.10 -5 0.404 O94832 R771H Polymorphism 0.479 0.290 0.09 3 0.377 O94851 F145L Polymorphism 0.488 0.822 0.00 15 0.599 O94851 I220V Polymorphism NA 0.631 0.00 -6 0.483 O94851 R1089Q Polymorphism 0.246 0.111 0.51 25 0.093 O94854 I824V Polymorphism NA 0.044 0.13 20 0.019 O94854 T969A Polymorphism NA 0.094 0.10 -12 0.075 O94854 E1058K Polymorphism NA 0.254 0.12 4 0.223 O94855 M42T Polymorphism NA 0.060 0.39 0 0.071 O94856 T159M Polymorphism 0.509 0.223 0.12 36 0.570 O94875 A1048V Polymorphism 0.135 0.941 0.05 55 0.398 O94885 P298Q Polymorphism NA 0.444 NA 14 0.282 O94885 Q884R Polymorphism NA 0.025 NA 31 0.024 O94901 H118Y Polymorphism NA 0.129 NA 15 0.217 O94903 V24M Polymorphism 0.540 0.244 0.01 -19 0.498 O94910 E595Q Polymorphism NA 0.324 0.53 -9 0.266 O94911 A416V Polymorphism 0.090 0.697 0.29 9 0.111 O94911 C680G Polymorphism 0.861 0.602 0.00 45 0.823 O94911 G331S Polymorphism 0.149 0.576 0.08 -28 0.217 O94911 T256A Polymorphism 0.064 0.158 0.57 -13 0.130 O94911 Y489F Polymorphism 0.602 0.425 0.32 9 0.517 O94915 I1878V Polymorphism 0.069 0.027 0.88 -36 0.060 O94921 S463R Polymorphism NA 0.167 0.10 47 0.187 O94927 A277D Polymorphism NA 0.137 NA 28 0.147 O94929 G125D Polymorphism 0.757 0.806 0.45 55 0.600 O94933 I605V Polymorphism 0.211 0.094 0.63 -2 0.146 O94941 L479P Polymorphism 0.287 0.148 NA -44 0.059 O94952 N180T Polymorphism NA 0.047 0.00 -8 0.084 O94953 N29T Polymorphism 0.239 0.704 0.39 34 0.398 O94953 K710E Polymorphism 0.115 0.195 0.30 -5 0.123 O94955 P21R Polymorphism NA 0.131 0.01 19 0.161 O94966 D36H Polymorphism NA 0.143 0.00 28 0.201 O94972 L76P Disease 0.742 0.725 0.00 37 0.820 O94972 C109S Disease 0.334 0.904 0.08 53 0.855 O94972 G322V Disease NA 0.943 0.00 39 0.802 O94972 T108A Polymorphism 0.267 0.449 0.03 47 0.564 O94972 V838I Polymorphism NA 0.160 NA 22 0.043 O94979 I263V Polymorphism 0.144 0.113 1.00 -19 0.108 O94979 N456K Polymorphism 0.328 0.274 0.36 -6 0.260 O94979 P1055T Polymorphism 0.412 0.299 0.54 -13 0.272 O94983 A267P Polymorphism 0.159 0.105 0.12 -45 0.009 O94985 F870S Polymorphism 0.474 0.862 0.00 30 0.811 O94985 P857H Polymorphism 0.262 0.759 0.00 51 0.515 O94985 V474A Polymorphism 0.360 0.360 0.31 39 0.313 O94986 S793I Polymorphism NA 0.128 0.02 29 0.131 O94989 P73S Polymorphism NA 0.194 0.54 34 0.221 O94989 G155V Polymorphism NA 0.249 0.02 35 0.307 O94989 L277P Polymorphism NA 0.115 0.13 -22 0.008 O94989 S831P Polymorphism 0.244 0.071 0.01 17 0.053 O95006 A98V Polymorphism 0.174 0.723 1.00 4 0.357 O95006 T170A Polymorphism 0.144 0.379 0.12 -8 0.131 O95006 Y278H Polymorphism 0.895 0.876 0.16 64 0.885 O95007 R143C Polymorphism 0.289 0.684 0.09 -4 0.371 O95045 R10S Polymorphism NA 0.085 NA -3 0.026 O95050 D28N Polymorphism 0.183 0.048 0.63 -20 0.085 O95050 E219G Polymorphism 0.555 0.306 0.04 24 0.512 O95050 F254C Polymorphism 0.062 0.658 0.04 38 0.268 O95050 M205V Polymorphism 0.079 0.241 0.18 27 0.232 O95050 N246S Polymorphism 0.181 0.121 0.36 6 0.200 O95050 R258H Polymorphism 0.698 0.339 0.02 34 0.604 O95067 M100T Polymorphism NA 0.287 0.19 17 0.339 O95072 R31C Polymorphism 0.845 0.737 0.06 53 0.932 O95072 P294L Polymorphism 0.119 0.142 0.25 -9 0.118 O95072 V411F Polymorphism 0.524 0.138 0.12 27 0.185 O95076 P234A Polymorphism 0.419 0.739 0.08 26 0.677 O95125 G533A Polymorphism 0.593 0.422 0.03 43 0.677 O95140 L76P Disease NA 0.643 0.06 17 0.687 O95140 R94Q Disease NA 0.855 0.12 33 0.790 O95140 R94W Disease NA 0.957 0.01 43 0.818 O95140 V69F Disease NA 0.404 0.25 27 0.289 O95140 H361Y Disease 0.662 0.778 0.09 50 0.849 O95140 K357N Disease 0.576 0.798 0.04 17 0.791 O95140 P251A Disease 0.434 0.592 0.05 30 0.722 O95140 Q276R Disease 0.603 0.670 0.03 28 0.746 O95140 R280H Disease 0.755 0.797 0.01 48 0.850 O95140 R364W Disease 0.874 0.798 0.04 24 0.847 O95140 T206I Disease 0.690 0.540 0.04 40 0.695 O95140 W740S Disease 0.115 0.414 0.45 21 0.352 O95150 F110L Polymorphism 0.077 0.055 0.66 -19 0.015 O95153 A586T Polymorphism 0.299 0.117 0.62 45 0.162 O95153 Q817R Polymorphism 0.092 0.100 0.88 -20 0.087 O95153 W851R Polymorphism 0.119 0.156 0.53 1 0.087 O95153 A1140P Polymorphism 0.267 0.077 0.30 -31 0.037 O95153 G1830E Polymorphism 0.599 0.307 0.03 27 0.543 O95154 T323A Polymorphism NA 0.142 1.00 -40 0.095 O95154 V138M Polymorphism 0.462 0.637 0.29 -13 0.446 O95163 E312K Polymorphism 0.035 0.096 0.22 8 0.108 O95163 G765E Polymorphism 0.279 0.078 1.00 -39 0.022 O95163 I830M Polymorphism 0.435 0.105 0.16 -12 0.225 O95163 K952I Polymorphism 0.491 0.355 0.08 5 0.496 O95163 R525Q Polymorphism 0.142 0.050 0.46 -30 0.098 O95163 R696P Disease 0.615 0.919 0.12 27 0.856 O95163 C1072S Polymorphism 0.146 0.344 0.26 -4 0.209 O95163 G1013S Polymorphism 0.661 0.539 0.06 4 0.708 O95163 P1158L Polymorphism 0.275 0.074 0.26 -34 0.129 O95171 K480R Polymorphism 0.140 0.134 0.30 -3 0.111 O95171 R386K Polymorphism 0.145 0.201 0.00 12 0.150 O95171 V336L Polymorphism 0.177 0.140 0.00 4 0.159 O95180 A748V Disease NA 0.124 0.28 7 0.187 O95180 C456S Disease NA 0.947 0.14 -2 0.776 O95180 E282K Disease NA 0.366 0.42 30 0.366 O95180 F161L Disease NA 0.866 0.84 26 0.492 O95180 G499S Disease 0.323 0.145 1.00 10 0.111 O95180 G773D Disease NA 0.645 0.21 0 0.492 O95180 G784S Disease 0.035 0.757 0.89 -27 0.132 O95180 G848S Disease 0.706 0.722 0.08 16 0.633 O95180 M313V Polymorphism NA 0.169 0.52 48 0.157 O95180 P648L Disease NA 0.288 0.11 2 0.237 O95180 P684S Polymorphism NA 0.103 0.88 -22 0.112 O95180 R744Q Disease NA 0.083 0.59 -40 0.103 O95180 R788C Polymorphism 0.689 0.594 0.18 20 0.789 O95180 V812M Polymorphism 0.394 0.423 1.00 -6 0.259 O95180 V831M Disease 0.394 0.614 0.00 0 0.543 O95180 D1463N Disease 0.354 0.586 0.45 25 0.415 O95185 G37V Polymorphism NA 0.276 0.22 -37 0.408 O95185 M721T Polymorphism 0.090 0.163 0.06 15 0.188 O95190 P70L Polymorphism 0.351 0.478 0.48 12 0.570 O95197 D501H Polymorphism 0.577 0.150 0.05 35 0.312 O95199 A263T Polymorphism 0.256 0.882 0.09 40 0.446 O95199 C515S Polymorphism 0.181 0.819 0.06 14 0.471 O95201 T43A Polymorphism NA 0.034 1.00 -1 0.032 O95201 A255D Polymorphism 0.296 0.744 0.10 -2 0.264 O95206 W7R Polymorphism 0.106 0.708 0.01 -12 0.328 O95206 T367A Polymorphism NA 0.317 NA 12 0.298 O95206 V743A Polymorphism 0.109 0.075 0.80 -1 0.182 O95221 Y278H Polymorphism 0.966 0.896 0.00 71 0.941 O95222 A22V Polymorphism 0.150 0.532 0.50 3 0.251 O95229 A4S Polymorphism NA 0.221 0.00 11 0.215 O95231 M79V Polymorphism NA 0.099 0.53 16 0.133 O95231 G191R Polymorphism NA 0.131 0.39 47 0.129 O95236 A135V Polymorphism 0.397 0.051 1.00 -31 0.056 O95237 S175R Disease 0.621 0.762 0.01 75 0.907 O95239 L1193S Polymorphism NA 0.066 0.20 -4 0.015 O95243 C61R Polymorphism NA 0.125 NA 32 0.092 O95243 E346K Polymorphism 0.183 0.024 NA 18 0.041 O95243 S342P Polymorphism 0.374 0.074 NA 1 0.063 O95255 G61D Polymorphism NA 0.709 0.51 35 0.676 O95255 A455P Disease 0.514 0.841 0.26 37 0.820 O95255 F568S Disease 0.520 0.780 0.15 55 0.784 O95255 H632Q Polymorphism 0.463 0.174 0.36 -14 0.158 O95255 I319V Polymorphism 0.066 0.172 0.87 -36 0.071 O95255 K281E Polymorphism NA 0.294 0.90 -20 0.242 O95255 L673P Disease 0.699 0.806 0.05 50 0.839 O95255 L953H Polymorphism 0.726 0.580 0.33 8 0.769 O95255 N411K Disease 0.964 0.913 0.49 65 0.777 O95255 N497K Polymorphism 0.112 0.468 0.03 55 0.557 O95255 R518Q Disease 0.387 0.931 0.34 61 0.648 O95255 R765Q Disease 0.997 0.892 0.00 66 0.942 O95255 T364R Disease 0.446 0.558 0.21 38 0.492 O95255 V665A Polymorphism 0.865 0.465 0.21 63 0.901 O95255 A1303P Disease 0.556 0.907 0.01 49 0.821 O95255 D1361N Disease 0.996 0.845 0.50 45 0.876 O95255 G1203D Disease 0.996 0.927 0.23 49 0.870 O95255 G1302R Disease 0.979 0.902 0.00 80 0.872 O95255 G1321S Disease 0.997 0.910 0.01 61 0.942 O95255 G1354R Disease 0.676 0.838 0.04 75 0.847 O95255 I1424T Disease 0.447 0.258 0.01 33 0.469 O95255 Q1347H Disease 0.999 0.621 0.00 68 0.927 O95255 R1114P Disease 0.990 0.886 0.03 72 0.923 O95255 R1138P Disease 0.979 0.939 0.01 71 0.928 O95255 R1138Q Disease 0.963 0.859 0.30 57 0.891 O95255 R1138W Disease 0.993 0.939 0.00 60 0.934 O95255 R1268Q Polymorphism 0.431 0.216 0.42 -24 0.193 O95255 R1314Q Disease 0.986 0.841 0.01 70 0.915 O95255 R1314W Disease 0.996 0.946 0.00 72 0.943 O95255 R1339C Disease 0.998 0.850 0.00 72 0.913 O95255 S1121W Disease 0.996 0.817 0.00 62 0.933 O95255 T1301I Disease 0.996 0.865 0.00 70 0.947 O95255 V1298F Disease 0.507 0.885 0.00 60 0.834 O95255 W1241C Polymorphism 0.384 0.291 0.02 -10 0.356 O95257 G112S Polymorphism 0.134 0.141 0.67 5 0.118 O95258 E55A Polymorphism 0.540 0.183 0.75 15 0.249 O95264 V183I Polymorphism 0.062 0.062 1.00 -5 0.045 O95264 Y129S Polymorphism 0.084 0.339 0.96 6 0.168 O95278 E28K Disease NA 0.467 0.00 50 0.466 O95278 F84L Disease NA 0.229 0.00 16 0.117 O95278 F88L Disease NA 0.492 0.00 21 0.495 O95278 R91P Disease NA 0.737 0.00 31 0.355 O95278 S25P Disease NA 0.451 0.00 60 0.460 O95278 W32G Disease NA 0.608 0.00 49 0.618 O95278 E210K Disease NA 0.186 0.15 36 0.337 O95278 G240S Disease NA 0.206 0.20 -3 0.166 O95278 G279S Disease NA 0.756 0.08 -10 0.595 O95278 K140N Disease NA 0.531 0.00 20 0.633 O95278 L310W Disease NA 0.506 0.10 37 0.646 O95278 N148Y Disease NA 0.329 0.00 2 0.245 O95278 P301L Disease NA 0.773 0.02 31 0.711 O95278 Q293L Disease NA 0.534 0.64 23 0.647 O95278 R108C Disease NA 0.694 0.00 63 0.873 O95278 R171H Disease NA 0.766 0.10 23 0.696 O95278 T187A Disease NA 0.397 0.03 39 0.597 O95278 T194I Disease NA 0.552 0.07 33 0.654 O95278 Y294N Disease NA 0.739 0.55 -14 0.546 O95279 P465T Polymorphism NA 0.145 NA -19 0.039 O95292 P56S Disease 0.900 0.914 0.00 58 0.944 O95294 T58M Polymorphism 0.584 0.234 0.22 39 0.551 O95294 V11L Polymorphism 0.204 0.448 0.03 1 0.338 O95299 A2G Polymorphism NA 0.222 0.00 20 0.231 O95319 D438H Polymorphism 0.627 0.832 0.00 26 0.857 O95340 E10K Polymorphism 0.079 0.177 NA -1 0.180 O95342 S56L Polymorphism 0.533 0.352 0.54 -15 0.542 O95342 A570T Disease 0.933 0.871 0.00 32 0.900 O95342 A865V Polymorphism 0.705 0.451 1.00 9 0.581 O95342 A926P Disease 0.832 0.722 0.20 31 0.822 O95342 C336S Disease 0.511 0.581 0.80 -33 0.202 O95342 D482G Disease 0.890 0.755 0.15 59 0.850 O95342 E186G Disease 0.868 0.603 0.39 38 0.822 O95342 E297G Disease 0.855 0.639 0.01 55 0.825 O95342 G238V Disease 0.529 0.867 0.16 30 0.532 O95342 G982R Disease 0.945 0.879 0.04 51 0.954 O95342 I206V Polymorphism 0.273 0.651 1.00 -28 0.194 O95342 K461E Disease 0.999 0.924 0.00 75 0.983 O95342 R432T Disease 0.991 0.910 0.06 57 0.976 O95342 R698H Polymorphism 0.299 0.451 0.55 2 0.329 O95342 R958Q Polymorphism 0.341 0.771 0.49 -5 0.173 O95342 T923P Disease 0.742 0.779 0.35 15 0.786 O95342 V284L Disease 0.640 0.568 0.50 20 0.742 O95342 V444D Polymorphism 0.291 0.740 0.56 -28 0.185 O95342 V444G Polymorphism 0.597 0.633 0.34 -3 0.484 O95342 E1186K Polymorphism 0.603 0.726 0.38 15 0.487 O95342 G1004D Disease 0.835 0.771 0.24 62 0.835 O95342 R1050C Disease 0.864 0.846 0.00 38 0.814 O95342 R1128H Disease 0.975 0.941 0.01 72 0.971 O95342 R1153C Disease 0.994 0.919 0.00 73 0.983 O95342 R1268Q Disease 0.853 0.945 0.07 63 0.929 O95343 G69D Disease NA 0.228 0.05 0 0.370 O95343 V92G Disease 0.964 0.896 0.00 42 0.946 O95343 H173P Disease 0.935 0.961 0.01 50 0.939 O95343 I105V Disease 0.254 0.416 0.56 -2 0.254 O95343 L226V Disease 0.341 0.634 0.19 22 0.529 O95343 P231R Disease 0.990 0.921 0.00 60 0.961 O95343 R257P Disease 0.961 0.967 0.01 74 0.956 O95343 R257W Disease 0.984 0.930 0.00 68 0.958 O95343 T202I Disease 0.971 0.946 0.03 34 0.944 O95343 V250A Disease 0.942 0.855 0.00 52 0.935 O95352 V471A Polymorphism 0.557 0.453 0.01 25 0.652 O95359 L830F Polymorphism NA 0.029 NA 30 0.038 O95359 V170I Polymorphism NA 0.029 NA 4 0.035 O95359 A1425T Polymorphism NA 0.102 NA -47 0.021 O95359 A2210V Polymorphism NA 0.044 0.01 -3 0.102 O95359 E1916K Polymorphism NA 0.227 NA 38 0.219 O95359 E2271D Polymorphism 0.228 0.311 0.10 11 0.268 O95359 I2078T Polymorphism NA 0.109 0.04 -28 0.078 O95359 L2261H Polymorphism NA 0.164 0.06 30 0.268 O95359 N2102S Polymorphism NA 0.040 0.13 -1 0.083 O95359 Q2900K Polymorphism 0.120 0.090 0.15 -4 0.130 O95359 V2718I Polymorphism NA 0.111 0.03 23 0.122 O95359 W1103R Polymorphism NA 0.030 NA -14 0.011 O95361 E121D Polymorphism 0.161 0.319 0.52 -46 0.246 O95363 N280S Polymorphism 0.288 0.298 0.77 -23 0.161 O95371 G16S Polymorphism 0.732 0.923 0.04 56 0.822 O95371 R229H Polymorphism 0.486 0.658 0.16 -1 0.444 O95373 T111N Polymorphism 0.594 0.269 0.16 -25 0.440 O95376 E24K Polymorphism NA 0.173 0.68 3 0.266 O95379 S151C Polymorphism 0.855 0.912 0.00 59 0.953 O95382 N622K Polymorphism NA 0.299 0.09 24 0.328 O95382 R544W Polymorphism NA 0.361 0.00 45 0.619 O95382 R668G Polymorphism 0.490 0.463 0.18 28 0.464 O95382 A1061T Polymorphism 0.108 0.110 0.07 -52 0.072 O95382 G1233A Polymorphism NA 0.089 0.04 -14 0.093 O95389 C78R Disease 0.981 0.940 0.00 65 0.971 O95393 N250K Polymorphism 0.109 0.339 0.89 -51 0.138 O95393 T200S Polymorphism 0.096 0.354 0.53 -61 0.161 O95394 D466N Polymorphism 0.296 0.500 0.53 9 0.333 O95396 S429A Polymorphism NA 0.153 0.54 -23 0.183 O95399 I12T Polymorphism 0.587 0.221 0.21 35 0.422 O95400 G231D Polymorphism 0.245 0.196 0.80 -24 0.156 O95405 Q414P Polymorphism NA 0.221 0.11 24 0.254 O95405 Y287C Polymorphism NA 0.109 NA -13 0.026 O95409 D37N Disease NA 0.159 0.75 3 0.098 O95409 Q36P Disease NA 0.321 0.41 6 0.117 O95409 C335F Disease 0.998 0.791 0.00 73 0.984 O95409 D128N Disease NA 0.182 0.00 17 0.250 O95409 D152F Disease NA 0.374 0.00 26 0.535 O95409 F314C Disease 0.950 0.741 0.00 74 0.974 O95409 H286L Disease 0.996 0.558 0.00 76 0.966 O95409 H286Q Disease 0.997 0.598 0.00 76 0.970 O95409 H286Y Disease 0.995 0.607 0.00 79 0.969 O95409 H291Y Disease 0.995 0.556 0.03 69 0.982 O95409 H327Y Disease 0.995 0.740 0.00 74 0.993 O95409 H404R Disease 0.816 0.450 0.33 25 0.491 O95409 H415Q Disease 0.852 0.691 0.00 71 0.953 O95409 R325L Disease 0.880 0.746 0.01 55 0.887 O95409 R325S Disease 0.864 0.689 0.01 53 0.887 O95409 R373P Disease 0.777 0.462 0.07 57 0.697 O95409 R409W Disease 0.959 0.570 0.18 48 0.880 O95409 S272N Disease 0.492 0.249 0.05 -6 0.365 O95409 T403K Disease 0.996 0.437 0.06 59 0.849 O95409 W304R Disease 0.997 0.603 0.23 55 0.940 O95409 Y402N Disease 0.874 0.580 0.00 56 0.878 O95415 T123A Polymorphism 0.074 0.128 NA 24 0.102 O95425 I2005V Polymorphism 0.127 0.073 0.19 16 0.173 O95425 S1688P Polymorphism 0.085 0.517 0.01 -27 0.104 O95425 V1041L Polymorphism NA 0.053 NA -10 0.080 O95427 F904C Polymorphism 0.752 0.910 0.00 -23 0.847 O95427 F904L Polymorphism 0.166 0.872 0.00 -55 0.416 O95427 H229D Polymorphism 0.401 0.264 0.87 -1 0.184 O95427 I470L Polymorphism 0.354 0.087 1.00 -17 0.083 O95427 K162E Polymorphism 0.248 0.196 1.00 -33 0.134 O95428 A191T Polymorphism 0.078 0.107 0.52 41 0.145 O95428 G896R Polymorphism NA 0.120 0.14 14 0.102 O95428 Q723H Polymorphism 0.039 0.202 0.12 38 0.281 O95428 V443I Polymorphism 0.083 0.338 0.33 23 0.218 O95436 G106R Disease 0.507 0.868 0.12 52 0.884 O95447 G17S Polymorphism 0.399 0.030 0.81 1 0.085 O95447 G547S Polymorphism 0.399 0.363 0.32 6 0.183 O95450 V74M Polymorphism NA 0.144 0.11 -4 0.254 O95450 E331K Polymorphism 0.487 0.484 0.80 41 0.513 O95450 G665R Polymorphism 0.788 0.213 0.33 26 0.427 O95450 R241H Polymorphism 0.555 0.414 0.11 -66 0.586 O95450 R827Q Polymorphism 0.545 0.534 0.21 37 0.517 O95450 V245I Polymorphism NA 0.070 0.66 -57 0.111 O95452 T5M Disease 0.574 0.563 0.14 11 0.699 O95452 A88V Disease 0.621 0.740 0.02 5 0.779 O95452 G11R Disease 0.411 0.837 0.05 -6 0.773 O95452 V37E Disease 0.794 0.836 0.12 22 0.847 O95452 S139G Polymorphism 0.562 0.906 0.02 30 0.859 O95455 G15S Polymorphism NA 0.124 1.00 -14 0.059 O95456 I166V Polymorphism NA 0.092 0.91 -42 0.070 O95460 L13F Polymorphism 0.281 0.349 NA -14 0.277 O95461 R68G Polymorphism NA 0.435 0.01 42 0.361 O95461 E509K Disease 0.396 0.466 0.01 38 0.393 O95471 A133T Polymorphism 0.142 0.689 0.82 -49 0.129 O95475 H141N Polymorphism 0.584 0.236 0.50 33 0.402 O95475 T165A Disease 0.929 0.908 0.10 -4 0.903 O95477 P85L Disease NA 0.369 0.63 0 0.387 O95477 A255T Disease NA 0.137 0.54 -37 0.071 O95477 A937V Disease 0.973 0.920 0.00 50 0.962 O95477 N935H Disease 0.996 0.872 0.00 76 0.903 O95477 N935S Disease 0.989 0.870 0.00 58 0.953 O95477 Q597R Disease 0.984 0.894 0.00 43 0.938 O95477 R230C Disease NA 0.353 0.14 44 0.539 O95477 R587W Disease 0.954 0.575 0.10 18 0.737 O95477 T774P Polymorphism NA 0.522 0.27 -7 0.410 O95477 T929I Disease 0.784 0.685 0.04 21 0.751 O95477 W590S Disease 0.899 0.475 0.33 20 0.687 O95477 A1046D Disease 0.989 0.854 0.00 52 0.959 O95477 C1477R Disease NA 0.895 0.00 59 0.903 O95477 D1099Y Disease 0.956 0.597 0.00 58 0.925 O95477 D1289N Disease NA 0.338 0.72 -40 0.263 O95477 E1172D Polymorphism NA 0.150 0.62 0 0.207 O95477 F2009S Disease 0.432 0.811 0.02 9 0.745 O95477 I1517R Disease NA 0.686 0.01 29 0.576 O95477 M1091T Disease 0.636 0.764 0.01 61 0.882 O95477 N1800H Disease 0.773 0.467 0.16 3 0.620 O95477 P2150L Disease 0.469 0.500 0.28 6 0.230 O95477 R1680W Disease 0.953 0.830 0.00 50 0.924 O95477 R2081W Disease 0.993 0.861 0.00 47 0.935 O95477 S1506L Disease NA 0.751 0.03 30 0.578 O95479 N484D Polymorphism 0.223 0.394 0.62 -4 0.132 O95479 P554L Polymorphism NA 0.134 0.00 28 0.162 O95479 R218Q Polymorphism 0.858 0.935 0.00 61 0.938 O95486 S261G Polymorphism NA 0.097 0.46 -18 0.066 O95486 T302I Polymorphism NA 0.097 0.28 -14 0.116 O95487 A456G Polymorphism NA 0.089 0.44 -18 0.100 O95497 T26I Polymorphism 0.383 0.102 1.00 -39 0.099 O95497 A325E Polymorphism 0.271 0.302 1.00 -24 0.214 O95498 T17N Polymorphism 0.298 0.099 0.16 -18 0.220 O95498 V30A Polymorphism 0.627 0.861 0.00 44 0.865 O95498 V241I Polymorphism 0.220 0.173 0.31 12 0.254 O95500 V85D Disease 0.868 0.815 0.00 43 0.860 O95521 A372G Polymorphism 0.485 0.750 0.16 32 0.614 O95521 R375C Polymorphism 0.669 0.644 0.15 21 0.747 O95522 T53K Polymorphism 0.382 0.155 1.00 -36 0.093 O95522 M157T Polymorphism 0.582 0.087 0.57 -9 0.087 O95528 S81R Disease 0.647 0.798 0.09 55 0.894 O95528 A206T Polymorphism 0.081 0.387 0.53 -20 0.237 O95528 E437K Disease NA 0.798 0.01 69 0.905 O95528 G142V Disease 0.284 0.438 0.53 -11 0.368 O95528 G246E Disease 0.840 0.931 0.00 68 0.921 O95528 G426W Disease NA 0.773 0.00 68 0.889 O95528 G445E Disease NA 0.941 0.09 26 0.771 O95528 R132W Disease 0.999 0.941 0.00 80 0.871 O95528 R231Q Disease 0.706 0.469 0.47 63 0.787 O95528 T518A Polymorphism NA 0.125 0.43 -25 0.197 O95544 N262K Polymorphism 0.198 0.716 0.08 12 0.406 O95551 S166G Polymorphism NA 0.215 0.42 10 0.200 O95561 M97V Polymorphism NA 0.023 NA 40 0.064 O95568 A325V Polymorphism 0.426 0.195 0.50 23 0.166 O95568 F309L Polymorphism 0.233 0.179 0.72 14 0.135 O95568 K360M Polymorphism 0.698 0.225 0.00 31 0.551 O95568 R318H Polymorphism 0.189 0.213 0.03 10 0.272 O95571 Y38C Disease NA 0.893 0.00 65 0.906 O95571 L185R Disease 0.936 0.887 0.00 61 0.914 O95571 R163W Disease 0.976 0.924 0.00 67 0.922 O95571 T136A Disease 0.709 0.694 0.00 52 0.756 O95602 I815V Polymorphism 0.321 0.064 0.35 6 0.164 O95602 K364E Polymorphism NA 0.277 0.28 -13 0.274 O95602 P150A Polymorphism 0.207 0.104 0.86 5 0.120 O95602 Q349E Polymorphism NA 0.280 0.90 9 0.315 O95602 I1608M Polymorphism 0.222 0.590 0.35 -30 0.408 O95613 T539I Polymorphism 0.386 0.183 0.01 -21 0.150 O95613 T879A Polymorphism 0.163 0.107 0.75 25 0.086 O95613 A2903T Polymorphism NA 0.060 0.28 12 0.087 O95613 I1639V Polymorphism 0.202 0.024 0.31 -51 0.017 O95613 L2975P Polymorphism NA 0.671 0.03 53 0.639 O95613 N1841S Polymorphism NA 0.046 0.33 -20 0.044 O95613 P2274L Polymorphism NA 0.044 NA 2 0.073 O95613 P2329R Polymorphism NA 0.033 NA 46 0.091 O95613 Q2361R Polymorphism NA 0.093 NA 33 0.096 O95613 Q2659H Polymorphism NA 0.068 0.10 37 0.141 O95613 R1953H Polymorphism NA 0.114 0.01 24 0.036 O95613 R2625Q Polymorphism NA 0.045 0.23 10 0.046 O95613 R2753H Polymorphism NA 0.174 0.02 44 0.260 O95613 S2191P Polymorphism NA 0.079 NA 43 0.107 O95613 S3091G Polymorphism NA 0.176 0.03 34 0.305 O95613 W2239R Polymorphism NA 0.151 NA 41 0.082 O95620 R230Q Polymorphism 0.102 0.275 0.69 -18 0.143 O95620 T178A Polymorphism 0.164 0.065 1.00 -33 0.041 O95628 A7G Polymorphism NA 0.076 0.00 -18 0.099 O95644 P68T Polymorphism NA 0.186 0.02 22 0.223 O95672 H328Y Polymorphism NA 0.214 0.14 0 0.210 O95678 R39C Polymorphism 0.632 0.803 0.18 45 0.814 O95678 R91G Polymorphism 0.626 0.448 1.00 25 0.503 O95678 E242G Polymorphism 0.958 0.852 0.00 47 0.906 O95678 E337K Disease 0.898 0.762 0.00 48 0.883 O95678 M427T Polymorphism 0.841 0.735 0.00 26 0.839 O95678 S485R Polymorphism 0.348 0.312 0.53 44 0.439 O95696 A321S Polymorphism 0.654 0.483 0.61 -31 0.614 O95704 G165R Polymorphism 0.641 0.947 0.00 36 0.860 O95711 M160V Polymorphism 0.079 0.058 0.63 13 0.033 O95711 Y121C Polymorphism 0.850 0.455 0.10 47 0.512 O95716 V64I Polymorphism 0.104 0.100 0.93 -30 0.109 O95718 A110V Disease 0.979 0.794 0.00 61 0.933 O95718 L320P Disease 0.874 0.891 0.00 48 0.896 O95718 L347P Disease 0.840 0.955 0.00 59 0.939 O95718 P386S Polymorphism 0.225 0.403 0.91 -8 0.262 O95718 T389M Disease 0.231 0.106 0.11 -19 0.118 O95718 V342L Disease 0.206 0.327 0.19 -40 0.256 O95727 E16A Polymorphism 0.128 0.068 0.36 -6 0.061 O95727 D173G Polymorphism 0.506 0.615 0.14 33 0.536 O95755 P50L Polymorphism NA 0.156 0.00 35 0.238 O95755 E320K Polymorphism NA 0.196 0.48 -8 0.215 O95760 I263M Polymorphism 0.276 0.140 0.06 46 0.203 O95780 T209I Polymorphism 0.529 0.256 0.07 7 0.561 O95786 R7C Polymorphism NA 0.159 0.06 27 0.176 O95789 K660R Polymorphism 0.153 0.108 0.19 15 0.183 O95789 E1233K Polymorphism 0.284 0.534 0.44 42 0.531 O95800 A116T Polymorphism NA 0.067 NA 39 0.059 O95800 C160G Polymorphism NA 0.355 NA 51 0.124 O95807 A58V Polymorphism 0.116 0.136 1.00 -19 0.053 O95807 F141L Polymorphism 0.135 0.544 0.66 13 0.290 O95813 R19W Polymorphism NA 0.093 NA 40 0.030 O95817 P407L Polymorphism 0.102 0.112 0.36 26 0.088 O95834 M33V Polymorphism 0.549 0.181 0.36 36 0.287 O95834 L187F Polymorphism 0.891 0.585 0.03 13 0.795 O95834 R357H Polymorphism 0.843 0.271 0.08 12 0.615 O95835 R96W Polymorphism NA 0.183 NA 35 0.158 O95835 P237Q Polymorphism NA 0.288 0.02 26 0.201 O95835 R370W Polymorphism NA 0.214 0.00 43 0.244 O95835 S204G Polymorphism NA 0.046 0.75 22 0.069 O95835 G1000S Polymorphism 0.106 0.844 0.09 33 0.232 O95838 H22L Polymorphism NA 0.132 NA 38 0.118 O95838 D470N Polymorphism 0.082 0.133 0.62 -32 0.096 O95838 R523H Polymorphism 0.027 0.116 0.11 26 0.080 O95843 A119V Polymorphism 0.698 0.582 0.00 23 0.772 O95847 I197T Polymorphism 0.211 0.300 0.01 -20 0.323 O95867 L63M Polymorphism NA 0.111 NA 50 0.125 O95868 S34T Polymorphism NA 0.123 NA 40 0.083 O95872 A112V Polymorphism 0.371 0.251 0.04 40 0.250 O95872 A235V Polymorphism 0.100 0.039 1.00 12 0.051 O95873 K92N Polymorphism NA 0.203 NA 19 0.170 O95897 R106Q Polymorphism NA 0.444 0.08 5 0.325 O95900 V93L Polymorphism 0.315 0.476 0.00 2 0.430 O95905 N501S Polymorphism 0.225 0.073 0.32 -35 0.064 O95905 R281G Polymorphism 0.648 0.661 0.07 31 0.708 O95918 A48V Polymorphism 0.190 0.194 0.50 6 0.097 O95918 T220A Polymorphism 0.530 0.173 0.49 -18 0.163 O95925 H92R Polymorphism 0.804 0.144 1.00 24 0.114 O95932 M58V Polymorphism NA 0.083 1.00 -3 0.062 O95944 M75V Polymorphism 0.195 0.041 0.30 18 0.021 O95944 I218K Polymorphism 0.531 0.408 0.00 49 0.452 O95947 S178F Polymorphism 0.948 0.880 0.00 58 0.942 O95954 A438E Polymorphism 0.127 0.330 0.06 -34 0.210 O95954 R135C Disease 0.654 0.862 0.00 60 0.907 O95954 R299P Disease 0.520 0.470 0.04 31 0.649 O95965 A154S Polymorphism 0.149 0.252 0.39 -47 0.170 O95967 E57K Disease 0.702 0.338 0.01 54 0.672 O95969 P53L Polymorphism 0.169 0.174 0.85 -7 0.107 O95969 V80A Polymorphism 0.135 0.056 0.72 -11 0.040 O95970 C42G Disease 0.679 0.825 0.00 54 0.901 O95970 C42R Disease 0.824 0.834 0.01 69 0.929 O95970 C46R Disease 0.723 0.895 0.00 76 0.921 O95970 L26R Disease NA 0.532 0.09 4 0.542 O95970 A110D Disease 0.727 0.910 0.01 59 0.802 O95970 C200R Disease 0.921 0.936 0.00 68 0.928 O95970 E123K Disease 0.559 0.697 0.18 38 0.646 O95970 E383A Disease NA 0.434 0.00 32 0.592 O95970 F318C Disease NA 0.756 0.00 67 0.873 O95970 I122K Disease 0.760 0.803 0.00 50 0.868 O95970 I298T Disease NA 0.280 0.03 46 0.423 O95970 L154P Disease 0.873 0.922 0.00 47 0.887 O95970 L232P Disease NA 0.816 0.15 52 0.671 O95970 R136W Disease 0.927 0.870 0.03 23 0.848 O95970 S145R Disease 0.725 0.732 0.28 48 0.641 O95970 S473L Disease 0.763 0.622 0.00 43 0.810 O95970 V432E Disease 0.606 0.694 0.01 54 0.856 O95971 I91V Polymorphism NA 0.083 NA 0 0.024 O95972 R61Q Disease 0.085 0.151 0.58 -56 0.084 O95972 R61W Disease 0.394 0.385 0.02 -52 0.547 O95972 R68W Disease 0.915 0.693 0.18 21 0.837 O95972 R76C Disease 0.886 0.535 0.06 34 0.723 O95972 R76H Disease 0.747 0.354 0.14 3 0.556 O95972 A180T Disease 0.326 0.150 0.57 -23 0.121 O95972 I243V Disease 0.096 0.091 0.58 -74 0.105 O95972 L148P Disease 0.618 0.366 0.23 19 0.511 O95972 N103S Polymorphism 0.086 0.131 0.43 -61 0.075 O95972 N196K Disease 0.344 0.266 0.99 -9 0.240 O95972 R138H Disease 0.588 0.328 0.22 16 0.441 O95972 R206H Disease 0.607 0.401 0.08 -2 0.529 O95972 W221R Disease 0.414 0.254 0.54 -11 0.247 O95972 Y235C Disease 0.667 0.678 0.09 6 0.778 O95976 Q74R Polymorphism NA 0.165 NA 1 0.025 O95976 N186K Polymorphism NA 0.018 NA -14 0.029 O95980 V275I Polymorphism 0.079 0.067 NA 28 0.053 O95988 G93R Polymorphism NA 0.080 0.51 6 0.029 O95990 A89S Polymorphism 0.226 0.130 NA -2 0.137 O95990 E141Q Polymorphism 0.162 0.105 NA -11 0.080 O95995 E199K Polymorphism NA 0.308 0.60 17 0.285 O95998 R91H Polymorphism NA 0.376 NA 9 0.173 O95998 R121Q Polymorphism NA 0.240 NA 35 0.157 O96007 T50A Polymorphism NA 0.293 0.15 13 0.387 O96007 T77A Polymorphism NA 0.595 0.56 23 0.548 O96007 E168K Disease 0.684 0.830 0.01 53 0.900 O96007 H123Y Polymorphism 0.885 0.911 0.00 67 0.938 O96013 A139T Polymorphism NA 0.096 0.30 -34 0.069 O96013 R135Q Polymorphism NA 0.092 0.55 1 0.082 O96017 E64K Disease NA 0.197 NA 42 0.362 O96017 D347N Polymorphism 0.697 0.825 0.01 71 0.913 O96017 E239K Disease NA 0.476 0.49 14 0.398 O96017 E501K Polymorphism NA 0.373 0.91 -12 0.231 O96017 F447I Polymorphism 0.176 0.882 0.04 52 0.710 O96017 G167R Disease NA 0.940 0.00 61 0.931 O96017 I157T Polymorphism NA 0.402 0.03 -25 0.427 O96017 I251F Disease NA 0.668 0.05 14 0.512 O96017 I448S Polymorphism 0.208 0.300 0.76 0 0.161 O96017 L436M Polymorphism 0.293 0.514 0.28 -17 0.357 O96017 L512V Polymorphism 0.092 0.081 0.65 -2 0.076 O96017 N446K Polymorphism 0.127 0.272 0.87 -17 0.162 O96017 R145P Disease NA 0.695 0.05 43 0.798 O96017 R145W Disease NA 0.787 0.01 44 0.813 O96017 R180C Disease NA 0.811 0.05 32 0.678 O96017 R180H Disease NA 0.428 0.11 40 0.356 O96017 R181C Disease NA 0.811 0.10 26 0.598 O96017 R181H Disease NA 0.401 0.30 3 0.289 O96017 R318H Disease 0.333 0.124 0.52 -22 0.137 O96017 R406H Polymorphism 0.351 0.700 0.09 -20 0.538 O96017 S500C Polymorphism NA 0.406 0.07 -2 0.424 O96017 T323P Disease 0.387 0.712 0.26 20 0.643 O96017 T476K Disease 0.459 0.745 0.05 39 0.608 O96017 Y327C Disease 0.676 0.388 0.11 44 0.579 O96018 K276T Polymorphism NA 0.551 0.14 31 0.747 O96020 N387S Polymorphism 0.041 0.086 0.55 -22 0.087 O96033 V7F Disease NA 0.342 0.29 -11 0.203 O97980 H16Y Polymorphism NA 0.369 NA 19 0.078 P00156 I7T Polymorphism 0.170 0.085 1.00 -55 0.089 P00156 N8S Polymorphism 0.339 0.700 0.00 29 0.593 P00156 A39T Polymorphism 0.340 0.366 0.01 -22 0.218 P00156 A39V Polymorphism 0.139 0.292 0.78 -36 0.139 P00156 A87P Polymorphism 0.912 0.851 0.00 62 0.846 P00156 F18L Polymorphism 0.148 0.271 0.17 -22 0.237 P00156 I78T Polymorphism 0.634 0.399 0.01 10 0.618 P00156 I78V Polymorphism 0.208 0.166 0.12 -19 0.219 P00156 A122T Polymorphism 0.157 0.407 0.47 -40 0.147 P00156 A191T Polymorphism 0.466 0.577 0.01 8 0.552 P00156 A229T Polymorphism 0.377 0.192 0.05 -47 0.219 P00156 A329T Polymorphism 0.248 0.222 0.03 -41 0.160 P00156 A330T Polymorphism 0.306 0.634 0.00 -37 0.469 P00156 D171N Disease 0.342 0.843 0.00 19 0.601 P00156 G251D Disease 0.474 0.849 0.00 57 0.896 P00156 I153T Polymorphism 0.539 0.613 0.00 17 0.543 P00156 I164V Polymorphism 0.302 0.244 0.02 9 0.345 P00156 I306T Polymorphism 0.329 0.124 0.04 -17 0.267 P00156 I334V Polymorphism 0.303 0.209 0.07 -24 0.268 P00156 L236I Polymorphism 0.356 0.241 1.00 -47 0.256 P00156 M316T Polymorphism 0.224 0.152 0.10 1 0.242 P00156 N260D Polymorphism 0.316 0.841 0.00 47 0.723 P00156 T123A Polymorphism 0.409 0.450 0.00 -5 0.559 P00156 T194A Polymorphism 0.293 0.070 0.30 -46 0.143 P00156 T360A Polymorphism NA 0.148 0.27 -41 0.211 P00156 T368I Polymorphism NA 0.305 1.00 -46 0.183 P00156 V353M Polymorphism NA 0.260 0.05 -20 0.283 P00156 V356M Disease NA 0.305 0.04 -12 0.318 P00325 N57K Polymorphism 0.141 0.272 1.00 -23 0.127 P00326 R48H Polymorphism 0.221 0.148 1.00 -1 0.079 P00326 I350V Polymorphism NA 0.107 0.39 -50 0.164 P00326 P166S Polymorphism 0.384 0.805 0.01 32 0.583 P00326 P352T Polymorphism NA 0.425 0.13 -16 0.290 P00367 E349A Disease 0.322 0.175 0.82 -25 0.214 P00367 G499D Disease 0.403 0.829 0.06 58 0.711 P00367 G499S Disease 0.271 0.804 0.30 30 0.483 P00367 H507Y Disease 0.566 0.485 0.02 10 0.530 P00367 R274C Disease 0.892 0.917 0.07 57 0.929 P00367 R318K Disease 0.202 0.449 1.00 -48 0.223 P00367 R318T Disease 0.486 0.596 0.02 14 0.585 P00367 R322C Disease 0.884 0.701 0.00 5 0.824 P00367 R322H Disease 0.565 0.519 0.01 -46 0.592 P00367 S270C Disease 0.877 0.705 0.04 19 0.830 P00367 S498L Disease 0.331 0.131 0.06 -8 0.265 P00367 S501P Disease 0.621 0.713 0.11 50 0.870 P00367 Y319C Disease 0.764 0.761 0.13 3 0.768 P00387 L73P Disease 0.933 0.915 0.00 46 0.915 P00387 R58Q Disease 0.583 0.655 0.12 12 0.563 P00387 S66P Polymorphism 0.782 0.573 0.03 -4 0.668 P00387 A179V Disease NA 0.908 0.00 58 0.854 P00387 C204R Disease NA 0.655 0.02 60 0.756 P00387 C204Y Disease NA 0.705 0.02 46 0.834 P00387 G292D Disease NA 0.876 0.02 37 0.779 P00387 L149P Disease 0.938 0.904 0.01 43 0.886 P00387 S128P Disease 0.814 0.881 0.00 77 0.931 P00387 T117S Polymorphism 0.198 0.181 0.15 -8 0.203 P00387 V106M Disease 0.867 0.585 0.05 -9 0.826 P00390 E297D Polymorphism 0.357 0.238 0.30 -22 0.391 P00390 G232R Polymorphism 0.140 0.866 0.27 -35 0.187 P00390 G232S Polymorphism 0.234 0.679 0.21 -32 0.352 P00390 R153C Polymorphism 0.943 0.842 0.00 40 0.895 P00395 F235S Polymorphism 0.926 0.870 0.00 49 0.917 P00395 F305L Polymorphism 0.567 0.872 0.00 41 0.886 P00395 G224A Polymorphism 0.284 0.799 0.13 27 0.612 P00395 L196I Disease 0.372 0.759 0.09 -52 0.482 P00395 S142F Disease 0.810 0.959 0.00 60 0.933 P00403 D11A Polymorphism NA 0.879 0.00 51 0.894 P00403 I30V Polymorphism NA 0.158 0.20 -18 0.248 P00403 M29K Disease NA 0.738 0.00 43 0.821 P00403 A148T Polymorphism 0.293 0.094 1.00 -32 0.094 P00403 L123P Polymorphism 0.345 0.758 0.00 27 0.627 P00403 T187M Polymorphism 0.772 0.414 0.27 3 0.545 P00414 F35S Polymorphism 0.096 0.755 0.04 33 0.620 P00414 G78S Disease 0.179 0.876 0.08 46 0.238 P00414 A200T Disease 0.203 0.848 0.07 -12 0.343 P00414 Q177R Polymorphism 0.316 0.814 0.00 58 0.765 P00439 A47V Disease 0.521 0.146 0.05 44 0.349 P00439 D84Y Disease 0.795 0.817 0.00 55 0.910 P00439 E56D Disease 0.444 0.480 0.21 27 0.410 P00439 E76A Disease 0.423 0.319 0.35 42 0.447 P00439 F39L Disease 0.407 0.806 0.06 29 0.595 P00439 F55L Disease 0.377 0.877 0.20 36 0.629 P00439 G46S Disease 0.332 0.715 0.57 41 0.547 P00439 I65N Disease 0.944 0.850 0.00 39 0.884 P00439 I65T Disease 0.808 0.662 0.01 37 0.815 P00439 K42I Disease 0.750 0.562 0.02 18 0.745 P00439 L41F Disease 0.715 0.704 0.05 39 0.847 P00439 L41P Disease 0.685 0.950 0.10 39 0.718 P00439 L48S Disease 0.853 0.952 0.00 56 0.940 P00439 L98S Disease 0.943 0.833 0.59 38 0.855 P00439 Q20L Disease NA 0.090 0.28 -39 0.066 P00439 R53H Disease 0.542 0.348 0.01 12 0.571 P00439 R68S Disease 0.690 0.980 0.00 50 0.705 P00439 S16P Disease NA 0.201 0.29 12 0.330 P00439 S40L Disease 0.417 0.723 0.01 21 0.740 P00439 S67P Disease 0.760 0.935 0.01 53 0.921 P00439 S87R Disease 0.283 0.412 0.70 40 0.317 P00439 T92I Disease 0.194 0.150 0.43 -36 0.102 P00439 A104D Disease 0.322 0.511 0.04 31 0.482 P00439 A246D Disease 0.940 0.822 0.03 49 0.915 P00439 A259T Disease 0.883 0.873 0.00 21 0.876 P00439 A259V Disease 0.924 0.860 0.00 22 0.877 P00439 A300S Disease 0.771 0.885 0.00 21 0.848 P00439 A300V Disease 0.882 0.821 0.00 30 0.846 P00439 A309D Disease 0.882 0.918 0.01 55 0.933 P00439 A309V Disease 0.560 0.727 0.07 28 0.678 P00439 A322G Disease 0.742 0.871 0.03 21 0.766 P00439 A322T Disease 0.681 0.766 0.01 23 0.771 P00439 A342T Disease 0.723 0.618 0.09 28 0.778 P00439 A345S Disease 0.761 0.876 0.01 35 0.777 P00439 A345T Disease 0.807 0.848 0.00 43 0.869 P00439 A395G Disease 0.845 0.874 0.04 6 0.846 P00439 A395P Disease 0.920 0.958 0.04 37 0.889 P00439 A403V Disease 0.356 0.420 0.09 12 0.330 P00439 A447D Disease 0.924 0.961 0.00 46 0.901 P00439 C217G Disease 0.507 0.907 0.12 31 0.633 P00439 C265G Disease 0.705 0.887 0.02 38 0.874 P00439 C334S Disease 0.755 0.912 0.00 32 0.876 P00439 C357G Disease 0.476 0.463 0.11 35 0.573 P00439 D129Y Disease 0.957 0.987 0.00 44 0.912 P00439 D143G Disease 0.829 0.947 0.02 34 0.869 P00439 D145V Disease 0.885 0.937 0.00 39 0.889 P00439 D151H Disease 0.971 0.961 0.00 51 0.951 P00439 D222V Disease 0.897 0.784 0.00 34 0.865 P00439 D282N Disease 0.762 0.909 0.01 49 0.912 P00439 D338Y Disease 0.904 0.666 0.00 33 0.830 P00439 D394A Disease 0.685 0.607 0.21 15 0.761 P00439 D394H Disease 0.812 0.716 0.02 23 0.768 P00439 D415N Disease 0.265 0.416 1.00 31 0.308 P00439 E178G Disease 0.687 0.765 0.02 24 0.844 P00439 E183Q Disease 0.837 0.784 0.01 33 0.809 P00439 E205A Disease 0.573 0.812 0.08 28 0.588 P00439 E221G Disease 0.687 0.706 0.13 21 0.777 P00439 E280K Disease 0.797 0.939 0.00 27 0.870 P00439 E330D Disease 0.695 0.930 0.00 54 0.920 P00439 E390G Disease 0.742 0.801 0.01 42 0.853 P00439 F161S Disease 0.891 0.926 0.01 23 0.886 P00439 F233L Disease 0.408 0.680 0.06 16 0.607 P00439 F240S Disease 0.880 0.862 0.00 15 0.876 P00439 F263L Disease 0.840 0.952 0.00 33 0.817 P00439 F299C Disease 0.949 0.913 0.00 42 0.898 P00439 F331L Disease 0.792 0.955 0.01 31 0.871 P00439 F410S Disease 0.885 0.968 0.03 32 0.881 P00439 G148S Disease 0.951 0.949 0.00 20 0.897 P00439 G171A Disease 0.790 0.887 0.05 17 0.695 P00439 G171R Disease 0.957 0.965 0.01 35 0.897 P00439 G218V Disease 0.366 0.869 0.14 29 0.628 P00439 G239S Disease 0.870 0.876 0.00 33 0.872 P00439 G247V Disease 0.976 0.895 0.00 51 0.942 P00439 G257C Disease 0.879 0.599 0.04 19 0.776 P00439 G337V Disease 0.489 0.638 0.14 23 0.748 P00439 G344R Disease 0.926 0.941 0.00 70 0.950 P00439 G344V Disease 0.920 0.931 0.00 60 0.949 P00439 H146Y Disease 0.790 0.983 0.00 41 0.871 P00439 H170D Disease 0.830 0.948 0.02 39 0.878 P00439 H170R Disease 0.786 0.867 0.04 25 0.838 P00439 H201R Disease 0.901 0.473 0.50 28 0.654 P00439 H201Y Disease 0.541 0.824 0.02 33 0.619 P00439 H264L Disease 0.568 0.834 0.18 30 0.841 P00439 H271Y Disease 0.886 0.925 0.01 36 0.886 P00439 I164T Disease 0.680 0.775 0.02 23 0.818 P00439 I174T Disease 0.802 0.863 0.01 21 0.861 P00439 I174V Disease 0.483 0.549 0.18 11 0.467 P00439 I224M Disease 0.692 0.860 0.00 24 0.862 P00439 I269L Disease 0.268 0.890 0.33 20 0.521 P00439 I283F Disease 0.434 0.723 0.66 21 0.498 P00439 I283N Disease 0.614 0.765 0.24 33 0.823 P00439 I306V Disease 0.559 0.409 0.10 22 0.610 P00439 I318T Disease 0.793 0.737 0.01 18 0.817 P00439 K274E Polymorphism 0.232 0.473 1.00 18 0.225 P00439 K341R Disease 0.335 0.398 0.82 27 0.329 P00439 K341T Disease 0.870 0.730 0.01 42 0.855 P00439 L194P Disease 0.935 0.853 0.01 47 0.892 P00439 L212P Disease 0.780 0.899 0.03 40 0.869 P00439 L213P Disease 0.974 0.962 0.00 47 0.928 P00439 L242F Disease 0.783 0.357 0.02 20 0.630 P00439 L248P Disease 0.868 0.923 0.00 36 0.882 P00439 L249F Disease 0.888 0.470 0.01 22 0.694 P00439 L255S Disease 0.444 0.651 0.00 23 0.750 P00439 L255V Disease 0.761 0.449 0.02 18 0.669 P00439 L311P Disease 0.944 0.937 0.00 27 0.896 P00439 L333F Disease 0.765 0.799 0.01 35 0.848 P00439 L347F Disease 0.800 0.524 0.01 30 0.769 P00439 L348V Disease 0.857 0.552 0.09 50 0.816 P00439 L430P Disease 0.836 0.896 0.01 44 0.886 P00439 M276I Disease 0.340 0.442 0.39 0 0.513 P00439 M276V Disease 0.183 0.614 0.50 1 0.499 P00439 N167I Disease 0.708 0.512 0.16 23 0.727 P00439 N167S Disease 0.207 0.352 0.75 14 0.256 P00439 N207D Disease 0.439 0.486 0.02 25 0.539 P00439 N207S Disease 0.346 0.307 0.05 13 0.440 P00439 P173T Disease 0.390 0.903 0.02 31 0.797 P00439 P175A Disease 0.381 0.856 0.07 34 0.768 P00439 P211T Disease 0.420 0.528 0.22 10 0.477 P00439 P225R Disease 0.933 0.915 0.00 44 0.903 P00439 P225T Disease 0.814 0.889 0.00 36 0.880 P00439 P244L Disease 0.934 0.779 0.01 33 0.864 P00439 P281L Disease 0.858 0.923 0.00 26 0.881 P00439 P314H Disease 0.831 0.236 0.01 22 0.572 P00439 P362T Disease 0.574 0.378 0.03 20 0.621 P00439 P366H Disease 0.592 0.275 0.05 32 0.598 P00439 P407S Disease 0.265 0.372 0.74 7 0.274 P00439 Q160P Disease 0.496 0.823 0.17 33 0.810 P00439 Q304R Disease 0.927 0.803 0.01 21 0.855 P00439 R155P Disease 0.925 0.988 0.03 41 0.891 P00439 R157N Disease 0.912 0.967 0.01 34 0.885 P00439 R158Q Disease 0.840 0.977 0.00 39 0.881 P00439 R158W Disease 0.979 0.972 0.00 47 0.926 P00439 R169H Disease 0.718 0.721 0.01 28 0.821 P00439 R176L Disease 0.419 0.816 0.63 27 0.597 P00439 R176P Disease 0.701 0.941 0.19 24 0.862 P00439 R241C Disease 0.797 0.525 0.05 30 0.735 P00439 R241H Disease 0.507 0.206 0.13 12 0.419 P00439 R241L Disease 0.463 0.424 0.30 22 0.535 P00439 R243Q Disease 0.791 0.705 0.04 44 0.784 P00439 R252G Disease 0.897 0.835 0.02 30 0.830 P00439 R252Q Disease 0.804 0.800 0.08 31 0.772 P00439 R252W Disease 0.971 0.868 0.00 38 0.923 P00439 R261P Disease 0.914 0.978 0.00 62 0.943 P00439 R261Q Disease 0.834 0.923 0.05 41 0.872 P00439 R270K Disease 0.691 0.909 0.00 60 0.915 P00439 R270S Disease 0.803 0.938 0.00 57 0.946 P00439 R297C Disease 0.217 0.625 0.01 36 0.668 P00439 R297H Disease 0.515 0.358 0.09 22 0.575 P00439 R408Q Disease 0.682 0.958 0.01 36 0.863 P00439 R408W Disease 0.960 0.960 0.00 42 0.889 P00439 R413P Disease 0.797 0.968 0.17 45 0.883 P00439 R413S Disease 0.607 0.920 0.27 37 0.635 P00439 S110C Disease 0.537 0.199 0.06 40 0.428 P00439 S231F Disease 0.951 0.776 0.00 30 0.868 P00439 S231P Disease 0.897 0.932 0.02 49 0.928 P00439 S273F Disease 0.889 0.780 0.01 22 0.848 P00439 S303P Disease 0.879 0.912 0.02 47 0.896 P00439 S310F Disease 0.910 0.770 0.00 31 0.833 P00439 S349L Disease 0.804 0.940 0.00 45 0.888 P00439 S349P Disease 0.904 0.963 0.00 57 0.946 P00439 S350T Disease 0.798 0.814 0.01 54 0.923 P00439 T124I Disease 0.449 0.286 0.02 17 0.408 P00439 T238P Disease 0.904 0.975 0.00 40 0.893 P00439 T278A Disease 0.622 0.536 0.11 21 0.735 P00439 T278N Disease 0.857 0.629 0.07 26 0.808 P00439 T372S Disease 0.554 0.444 0.03 20 0.637 P00439 T380M Disease 0.903 0.470 0.05 44 0.720 P00439 T418P Disease 0.859 0.983 0.00 39 0.882 P00439 V177L Disease 0.582 0.714 0.04 27 0.594 P00439 V190A Disease 0.770 0.422 0.00 22 0.655 P00439 V230I Disease 0.388 0.108 0.40 -1 0.182 P00439 V245A Disease 0.459 0.769 0.11 33 0.570 P00439 V245E Disease 0.804 0.913 0.00 65 0.939 P00439 V245L Disease 0.636 0.892 0.02 33 0.863 P00439 V388L Disease 0.458 0.831 0.06 33 0.628 P00439 V388M Disease 0.648 0.830 0.00 40 0.820 P00439 Y154N Disease 0.899 0.940 0.00 37 0.892 P00439 Y204C Disease 0.599 0.269 0.09 37 0.520 P00439 Y206D Disease 0.958 0.886 0.01 44 0.905 P00439 Y277C Disease 0.959 0.844 0.01 44 0.895 P00439 Y277D Disease 0.910 0.920 0.07 39 0.891 P00439 Y325C Disease 0.950 0.884 0.00 51 0.936 P00439 Y343C Disease 0.940 0.883 0.00 64 0.941 P00439 Y377C Disease 0.254 0.739 0.17 51 0.477 P00439 Y386C Disease 0.951 0.912 0.00 59 0.946 P00439 Y387H Disease 0.703 0.554 0.00 45 0.804 P00439 Y414C Disease 0.961 0.854 0.00 60 0.943 P00441 A5S Disease NA 0.918 0.00 27 0.784 P00441 A5T Disease NA 0.909 0.00 42 0.864 P00441 A5V Disease NA 0.923 0.00 32 0.858 P00441 C7F Disease NA 0.732 0.00 34 0.802 P00441 L9Q Disease NA 0.859 0.00 43 0.811 P00441 L9V Disease NA 0.781 0.14 4 0.517 P00441 V8E Disease NA 0.877 0.00 53 0.752 P00441 A90T Disease 0.401 0.681 0.25 4 0.435 P00441 A90V Disease 0.429 0.762 0.34 7 0.434 P00441 D77Y Disease 0.807 0.862 0.00 48 0.890 P00441 D91A Disease 0.335 0.565 0.18 23 0.498 P00441 D91V Disease 0.540 0.606 0.05 28 0.565 P00441 E22G Disease NA 0.474 0.13 22 0.500 P00441 E22K Disease NA 0.552 0.41 16 0.431 P00441 E50K Disease 0.264 0.777 0.12 46 0.627 P00441 F21C Disease NA 0.911 0.00 52 0.892 P00441 F46C Disease 0.949 0.820 0.00 47 0.905 P00441 G13R Disease NA 0.558 0.06 39 0.787 P00441 G17S Disease NA 0.888 0.00 52 0.889 P00441 G38R Disease 0.955 0.918 0.00 55 0.943 P00441 G42D Disease 0.800 0.830 0.00 63 0.922 P00441 G42S Disease 0.578 0.829 0.10 52 0.693 P00441 G73S Disease 0.901 0.861 0.01 40 0.864 P00441 G86R Disease 0.956 0.897 0.02 50 0.936 P00441 G94A Disease 0.488 0.766 0.03 53 0.688 P00441 G94C Disease 0.678 0.872 0.04 50 0.853 P00441 G94D Disease 0.855 0.843 0.00 67 0.925 P00441 G94R Disease 0.847 0.902 0.00 68 0.902 P00441 G94V Disease 0.739 0.829 0.00 57 0.912 P00441 H44R Disease 0.372 0.853 0.28 56 0.666 P00441 H47R Disease 0.972 0.892 0.00 71 0.946 P00441 H49Q Disease 0.939 0.848 0.00 69 0.937 P00441 H49R Disease 0.915 0.896 0.00 73 0.935 P00441 H81A Disease 0.915 0.824 0.00 71 0.928 P00441 L39R Disease 0.746 0.917 0.01 76 0.935 P00441 L39V Disease 0.559 0.849 0.01 60 0.858 P00441 L68R Disease 0.218 0.468 0.36 -7 0.288 P00441 L85F Disease 0.660 0.745 0.08 40 0.757 P00441 L85V Disease 0.572 0.814 0.00 51 0.883 P00441 N66S Disease 0.851 0.842 0.00 56 0.882 P00441 N87S Disease 0.853 0.872 0.00 45 0.847 P00441 Q23L Disease NA 0.812 0.03 42 0.693 P00441 T55R Disease 0.801 0.838 0.02 44 0.852 P00441 V15G Disease NA 0.851 0.00 47 0.870 P00441 V15M Disease NA 0.911 0.00 53 0.893 P00441 V88A Disease 0.602 0.665 0.00 41 0.788 P00441 V98M Disease 0.443 0.559 0.21 32 0.490 P00441 A146T Disease 0.627 0.834 0.00 40 0.771 P00441 C147R Disease 0.984 0.950 0.00 70 0.953 P00441 D102G Disease 0.717 0.744 0.10 53 0.785 P00441 D102N Disease 0.638 0.665 0.01 43 0.700 P00441 D125G Disease 0.944 0.869 0.00 67 0.935 P00441 D125V Disease 0.981 0.863 0.00 69 0.945 P00441 D126H Disease 0.979 0.863 0.00 68 0.948 P00441 E101G Disease 0.368 0.317 0.26 20 0.455 P00441 E101K Disease 0.158 0.399 0.79 -11 0.158 P00441 G109V Disease 0.924 0.765 0.00 53 0.912 P00441 G115A Disease 0.882 0.807 0.00 58 0.922 P00441 G148R Disease 0.970 0.945 0.00 68 0.949 P00441 I105F Disease 0.716 0.818 0.00 39 0.836 P00441 I113M Disease 0.709 0.854 0.00 49 0.897 P00441 I113T Disease 0.708 0.795 0.00 49 0.891 P00441 I114T Disease 0.711 0.687 0.00 46 0.805 P00441 I150T Disease 0.737 0.920 0.00 55 0.921 P00441 I152T Disease 0.338 0.733 0.14 34 0.593 P00441 L107V Disease 0.654 0.794 0.06 34 0.749 P00441 L127S Disease 0.936 0.916 0.00 33 0.903 P00441 L145F Disease 0.459 0.601 0.03 34 0.781 P00441 L145S Disease 0.443 0.815 0.01 24 0.707 P00441 N140K Disease 0.687 0.868 0.00 49 0.897 P00441 R116G Disease 0.908 0.842 0.00 60 0.926 P00441 S106L Disease 0.481 0.603 0.06 26 0.763 P00441 S135N Disease 0.876 0.730 0.00 54 0.916 P00441 V119L Disease 0.581 0.870 0.00 43 0.865 P00441 V149G Disease 0.837 0.798 0.00 48 0.872 P00441 V149I Disease 0.201 0.354 0.44 10 0.280 P00450 D544E Polymorphism 0.495 0.435 0.01 54 0.654 P00450 P477L Polymorphism 0.969 0.493 0.00 42 0.928 P00450 R367C Polymorphism 0.568 0.633 0.00 32 0.642 P00450 T841R Polymorphism 0.629 0.359 0.02 24 0.585 P00451 A97P Disease 0.235 0.918 0.00 -4 0.673 P00451 D75E Disease 0.033 0.827 0.21 30 0.272 P00451 D75V Polymorphism 0.090 0.830 0.00 48 0.736 P00451 D75Y Disease 0.157 0.933 0.00 52 0.859 P00451 E30V Disease NA 0.748 0.01 52 0.748 P00451 E72K Disease 0.104 0.689 0.00 40 0.254 P00451 E98K Disease 0.111 0.806 0.00 31 0.371 P00451 G41C Disease NA 0.522 0.04 28 0.751 P00451 G89D Disease 0.930 0.894 0.00 29 0.893 P00451 G89V Disease 0.944 0.744 0.00 36 0.889 P00451 G92A Disease 0.861 0.788 0.00 46 0.891 P00451 G92V Disease 0.944 0.805 0.00 53 0.935 P00451 K67E Disease 0.450 0.836 0.00 45 0.861 P00451 K67N Disease 0.536 0.796 0.00 45 0.867 P00451 L26P Disease NA 0.804 0.00 34 0.841 P00451 L26R Disease NA 0.611 0.00 53 0.745 P00451 L69P Disease 0.136 0.590 0.00 21 0.496 P00451 R22T Disease NA 0.915 0.00 59 0.857 P00451 R48C Disease NA 0.628 0.00 45 0.763 P00451 R48K Disease NA 0.225 0.14 20 0.319 P00451 S19R Disease NA 0.428 0.01 13 0.336 P00451 V99D Disease 0.301 0.832 0.00 42 0.709 P00451 W33G Disease NA 0.913 0.00 55 0.901 P00451 Y24C Disease NA 0.954 0.00 56 0.911 P00451 Y25C Disease NA 0.936 0.00 53 0.893 P00451 Y35C Disease NA 0.905 0.00 55 0.897 P00451 Y35H Disease NA 0.772 0.00 46 0.847 P00451 A111T Disease 0.774 0.728 0.01 -13 0.796 P00451 A111V Disease 0.834 0.732 0.02 32 0.837 P00451 A219D Disease NA 0.413 0.00 60 0.678 P00451 A219T Disease NA 0.134 0.02 48 0.211 P00451 A303E Disease 0.168 0.530 0.12 49 0.599 P00451 A303P Disease 0.235 0.703 0.17 42 0.621 P00451 A315V Disease 0.120 0.322 0.08 9 0.230 P00451 A488G Disease 0.708 0.955 0.12 7 0.801 P00451 A663V Disease 0.345 0.194 0.05 8 0.316 P00451 A723T Disease 0.287 0.218 0.08 -36 0.304 P00451 C172W Disease 0.942 0.891 0.00 57 0.943 P00451 C198G Disease NA 0.901 0.00 41 0.865 P00451 C267Y Disease 0.315 0.823 0.00 48 0.717 P00451 C329F Disease 0.560 0.749 0.00 39 0.845 P00451 C348R Disease 0.553 0.952 0.00 32 0.792 P00451 C348S Disease 0.331 0.941 0.00 9 0.722 P00451 C348Y Disease 0.621 0.970 0.00 19 0.846 P00451 D101G Disease 0.171 0.926 0.00 30 0.728 P00451 D101H Disease 0.283 0.862 0.00 43 0.683 P00451 D101V Disease 0.248 0.828 0.00 35 0.709 P00451 D135G Disease 0.856 0.809 0.01 48 0.846 P00451 D135Y Disease 0.958 0.815 0.00 53 0.943 P00451 D145H Disease 0.149 0.500 0.00 13 0.556 P00451 D186G Disease 0.171 0.894 0.00 51 0.843 P00451 D186Y Disease 0.369 0.899 0.00 24 0.772 P00451 D222V Disease NA 0.824 0.00 53 0.879 P00451 D478N Disease 0.895 0.820 0.00 28 0.896 P00451 D544N Disease 0.893 0.766 0.00 43 0.875 P00451 D561G Disease 0.905 0.932 0.00 49 0.935 P00451 D561H Disease 0.957 0.883 0.00 48 0.915 P00451 D561Y Disease 0.974 0.935 0.00 54 0.961 P00451 D579A Disease 0.518 0.307 0.03 32 0.617 P00451 D579H Disease 0.700 0.350 0.07 40 0.632 P00451 D588G Disease 0.917 0.897 0.00 45 0.912 P00451 D588Y Disease 0.978 0.896 0.00 52 0.952 P00451 E129V Disease 0.930 0.648 0.00 44 0.834 P00451 E132D Disease 0.089 0.083 0.42 25 0.119 P00451 E141K Disease 0.592 0.242 0.02 52 0.645 P00451 E223K Disease NA 0.899 0.00 60 0.843 P00451 E284K Disease 0.508 0.363 0.01 47 0.654 P00451 E291G Disease 0.166 0.385 0.08 44 0.318 P00451 E291K Disease 0.111 0.255 0.14 49 0.241 P00451 E340K Disease 0.269 0.184 0.01 3 0.246 P00451 E409G Disease 0.729 0.916 0.00 24 0.856 P00451 E475K Disease 0.130 0.631 0.00 7 0.298 P00451 E739K Disease 0.308 0.341 0.15 38 0.541 P00451 F214V Disease NA 0.685 0.04 24 0.534 P00451 F295L Disease 0.069 0.295 0.90 -5 0.209 P00451 F312S Disease 0.203 0.500 0.50 25 0.406 P00451 F455C Disease 0.679 0.958 0.00 0 0.830 P00451 F484C Disease 0.700 0.961 0.00 25 0.858 P00451 F677L Disease 0.671 0.464 0.05 3 0.634 P00451 F698L Disease 0.245 0.096 0.49 26 0.163 P00451 G121S Disease 0.882 0.668 0.00 42 0.857 P00451 G130R Disease 0.948 0.767 0.00 62 0.924 P00451 G164D Disease NA 0.792 0.00 50 0.860 P00451 G164V Disease NA 0.508 0.00 41 0.801 P00451 G193R Disease NA 0.843 0.00 60 0.897 P00451 G224W Disease NA 0.360 0.00 56 0.663 P00451 G255V Disease 0.242 0.798 0.00 2 0.661 P00451 G263S Disease 0.148 0.398 0.03 44 0.364 P00451 G266E Disease 0.070 0.280 0.47 46 0.186 P00451 G278R Disease 0.268 0.561 0.05 64 0.830 P00451 G323E Disease 0.940 0.886 0.00 58 0.944 P00451 G439D Disease 0.888 0.918 0.00 54 0.902 P00451 G439S Disease 0.819 0.781 0.00 36 0.811 P00451 G439V Disease 0.909 0.764 0.00 52 0.920 P00451 G466E Disease 0.392 0.842 0.00 24 0.667 P00451 G474E Disease 0.661 0.404 0.00 43 0.655 P00451 G474R Disease 0.736 0.351 0.00 19 0.612 P00451 G477V Disease 0.709 0.466 0.02 13 0.693 P00451 G498R Disease 0.970 0.846 0.00 28 0.923 P00451 G513S Disease 0.136 0.324 0.12 11 0.235 P00451 G705V Disease 0.971 0.784 0.00 50 0.921 P00451 G710W Disease 0.922 0.232 0.01 42 0.602 P00451 G720D Disease 0.665 0.907 0.01 59 0.915 P00451 G720S Disease 0.541 0.794 0.01 22 0.734 P00451 H113R Disease 0.123 0.121 0.57 4 0.109 P00451 H113Y Disease 0.147 0.352 0.05 40 0.157 P00451 H275L Disease 0.144 0.588 0.00 40 0.625 P00451 I307S Disease 0.198 0.500 0.00 6 0.551 P00451 I331V Disease 0.109 0.074 0.38 8 0.120 P00451 I405F Disease 0.354 0.801 0.02 15 0.719 P00451 I405S Disease 0.419 0.826 0.00 14 0.776 P00451 I438F Disease 0.300 0.816 0.00 3 0.599 P00451 I494T Disease 0.767 0.766 0.00 26 0.859 P00451 I522Y Disease 0.663 0.568 0.00 11 0.763 P00451 I567T Disease 0.435 0.693 0.00 29 0.805 P00451 I585R Disease 0.383 0.198 0.86 11 0.196 P00451 I585T Disease 0.218 0.218 0.13 16 0.197 P00451 K108T Disease 0.160 0.692 0.00 33 0.625 P00451 K185T Disease 0.160 0.381 0.00 44 0.366 P00451 K427I Disease 0.485 0.136 0.00 -3 0.247 P00451 K444R Disease 0.729 0.891 0.00 -7 0.830 P00451 K529E Disease 0.259 0.289 0.04 49 0.270 P00451 L117F Disease 0.166 0.192 0.26 -2 0.194 P00451 L117R Disease 0.262 0.417 0.00 37 0.534 P00451 L217H Disease NA 0.650 0.00 10 0.583 P00451 L326P Disease 0.643 0.767 0.06 28 0.795 P00451 L327P Disease 0.643 0.720 0.00 37 0.847 P00451 L327V Disease 0.213 0.237 0.01 13 0.324 P00451 L431F Disease 0.259 0.382 0.33 1 0.338 P00451 L431S Disease 0.122 0.509 0.00 15 0.296 P00451 L594Q Disease 0.657 0.813 0.00 43 0.829 P00451 L644V Disease 0.257 0.421 0.16 0 0.379 P00451 L650F Disease 0.399 0.138 0.31 -15 0.186 P00451 L659P Disease 0.610 0.818 0.00 30 0.860 P00451 L725Q Disease 0.552 0.419 0.00 21 0.599 P00451 M110V Disease 0.062 0.118 0.07 33 0.125 P00451 M339T Disease 0.316 0.825 0.00 51 0.853 P00451 M586V Disease 0.239 0.079 0.14 6 0.114 P00451 M633I Disease 0.102 0.698 0.00 38 0.240 P00451 M681I Disease 0.214 0.125 0.10 30 0.209 P00451 M699T Disease 0.497 0.809 0.00 26 0.723 P00451 M699V Disease 0.298 0.645 0.31 -19 0.443 P00451 M701I Disease 0.235 0.174 0.14 44 0.292 P00451 M721I Disease 0.288 0.764 0.01 54 0.721 P00451 M721L Disease 0.180 0.746 0.32 48 0.395 P00451 N163K Disease NA 0.202 0.08 34 0.373 P00451 N254I Disease NA 0.860 0.00 58 0.898 P00451 N299I Disease 0.109 0.233 0.00 33 0.247 P00451 N583S Disease 0.254 0.095 0.12 15 0.203 P00451 N601D Disease 0.880 0.811 0.00 2 0.885 P00451 N601K Disease 0.925 0.856 0.00 15 0.860 P00451 N609I Disease 0.604 0.866 0.00 43 0.869 P00451 N631K Disease 0.214 0.891 0.00 32 0.728 P00451 N631S Disease 0.258 0.748 0.00 37 0.577 P00451 N637D Disease 0.888 0.908 0.00 51 0.931 P00451 N637S Disease 0.906 0.873 0.00 33 0.905 P00451 N713I Disease 0.606 0.171 0.00 33 0.380 P00451 P165S Disease NA 0.797 0.00 0 0.698 P00451 P262L Disease 0.206 0.526 0.00 12 0.624 P00451 P470L Disease 0.967 0.690 0.00 -35 0.740 P00451 P470R Disease 0.968 0.759 0.00 15 0.918 P00451 P470T Disease 0.956 0.780 0.00 -1 0.906 P00451 P540T Disease 0.955 0.789 0.00 29 0.901 P00451 P947R Disease NA 0.093 0.22 14 0.067 P00451 Q584H Disease 0.431 0.319 0.00 42 0.450 P00451 Q584K Disease 0.186 0.412 0.00 37 0.293 P00451 Q584R Disease 0.227 0.235 0.00 40 0.359 P00451 Q664P Disease 0.184 0.557 0.00 -16 0.324 P00451 R301C Disease 0.457 0.950 0.00 54 0.908 P00451 R301H Disease 0.254 0.692 0.16 45 0.502 P00451 R301L Disease 0.171 0.797 0.00 40 0.668 P00451 R391C Disease 0.718 0.950 0.00 53 0.904 P00451 R391H Disease 0.494 0.707 0.08 8 0.536 P00451 R391P Disease 0.538 0.917 0.04 9 0.840 P00451 R437P Disease 0.366 0.918 0.00 2 0.722 P00451 R437W Disease 0.619 0.902 0.00 44 0.784 P00451 R490G Disease 0.842 0.962 0.01 34 0.884 P00451 R503H Disease 0.234 0.283 0.08 -8 0.227 P00451 R546W Disease 0.807 0.420 0.01 48 0.633 P00451 R550C Disease 0.769 0.818 0.00 51 0.902 P00451 R550G Disease 0.465 0.788 0.01 39 0.739 P00451 R550H Disease 0.451 0.373 0.01 50 0.504 P00451 R560T Disease 0.364 0.615 0.00 58 0.657 P00451 R602G Disease 0.310 0.676 0.01 29 0.606 P00451 R612C Disease 0.738 0.782 0.00 50 0.877 P00451 R717L Disease 0.436 0.237 0.01 39 0.392 P00451 R717W Disease 0.817 0.623 0.00 46 0.785 P00451 R795G Polymorphism 0.063 0.140 0.27 30 0.116 P00451 S138R Disease 0.174 0.355 0.04 54 0.372 P00451 S176P Disease 0.216 0.535 0.06 31 0.390 P00451 S179P Disease 0.216 0.930 0.00 37 0.724 P00451 S189L Disease 0.166 0.731 0.00 22 0.407 P00451 S202N Disease NA 0.257 0.01 -10 0.364 P00451 S202R Disease NA 0.378 0.00 26 0.588 P00451 S308L Disease 0.166 0.284 0.31 19 0.146 P00451 S392L Disease NA 0.349 0.04 -44 0.530 P00451 S392P Disease NA 0.601 0.09 -18 0.475 P00451 S553P Disease 0.405 0.737 0.02 41 0.782 P00451 S554C Disease 0.943 0.974 0.00 41 0.911 P00451 S554G Disease 0.843 0.955 0.00 39 0.890 P00451 S577F Disease 0.659 0.580 0.00 33 0.779 P00451 S596P Disease 0.498 0.668 0.01 42 0.798 P00451 S603I Disease 0.956 0.912 0.00 35 0.926 P00451 S603R Disease 0.943 0.921 0.00 44 0.913 P00451 S635N Disease 0.414 0.359 0.00 -8 0.563 P00451 T137A Disease 0.439 0.248 0.01 38 0.411 P00451 T137I Disease 0.666 0.354 0.00 35 0.643 P00451 T252I Disease NA 0.268 0.00 24 0.405 P00451 T294I Disease 0.131 0.518 0.03 20 0.236 P00451 T314A Disease 0.075 0.558 0.02 13 0.153 P00451 T314I Disease 0.131 0.654 0.00 13 0.299 P00451 T454I Disease 0.323 0.637 0.00 8 0.639 P00451 T479R Disease 0.233 0.436 0.00 33 0.388 P00451 T541S Disease 0.205 0.362 0.00 18 0.328 P00451 T686R Disease 0.430 0.360 0.00 60 0.491 P00451 V104D Disease 0.301 0.412 0.02 39 0.584 P00451 V147D Disease 0.336 0.848 0.00 52 0.864 P00451 V159A Disease 0.116 0.157 0.24 24 0.169 P00451 V181E Disease 0.243 0.641 0.15 65 0.520 P00451 V181M Disease 0.198 0.370 0.01 49 0.488 P00451 V220G Disease NA 0.769 0.00 44 0.841 P00451 V253F Disease NA 0.355 0.00 -6 0.556 P00451 V285G Disease 0.228 0.397 0.00 28 0.483 P00451 V297A Disease 0.116 0.075 0.19 21 0.107 P00451 V345A Disease 0.261 0.590 0.00 59 0.564 P00451 V345L Disease 0.170 0.620 0.01 32 0.385 P00451 V556D Disease 0.728 0.809 0.00 59 0.908 P00451 V578A Disease 0.384 0.197 0.01 15 0.222 P00451 V653A Disease 0.400 0.101 0.07 -27 0.212 P00451 V653M Disease 0.547 0.123 0.01 -41 0.379 P00451 V682F Disease 0.439 0.161 0.06 7 0.250 P00451 V727F Disease 0.565 0.709 0.05 58 0.867 P00451 W274C Disease 0.449 0.912 0.00 41 0.864 P00451 W401G Disease 0.853 0.579 0.01 44 0.799 P00451 W412G Disease 0.853 0.924 0.00 45 0.898 P00451 W412R Disease 0.888 0.881 0.00 40 0.908 P00451 W532G Disease 0.950 0.905 0.00 50 0.943 P00451 W604C Disease 0.962 0.940 0.00 57 0.961 P00451 Y133C Disease 0.962 0.910 0.00 52 0.956 P00451 Y155H Disease 0.221 0.808 0.00 53 0.850 P00451 Y365C Disease 0.287 0.389 0.00 -39 0.553 P00451 Y442C Disease 0.705 0.959 0.00 40 0.869 P00451 Y450D Disease 0.543 0.891 0.00 19 0.852 P00451 Y450N Disease 0.503 0.837 0.00 18 0.801 P00451 Y492C Disease 0.796 0.921 0.00 41 0.884 P00451 Y492H Disease 0.476 0.742 0.00 15 0.627 P00451 Y605H Disease 0.834 0.811 0.00 34 0.828 P00451 Y605S Disease 0.876 0.867 0.00 6 0.889 P00451 Y639C Disease 0.653 0.714 0.00 27 0.838 P00451 Y683C Disease 0.829 0.500 0.01 40 0.785 P00451 Y683N Disease 0.679 0.267 0.10 32 0.584 P00451 Y742C Disease 0.524 0.563 0.01 31 0.728 P00451 A1610S Disease NA 0.096 1.00 -34 0.027 P00451 A1798P Disease 0.937 0.906 0.00 40 0.912 P00451 A1853T Disease 0.178 0.157 0.32 36 0.167 P00451 A1853V Disease 0.382 0.298 0.01 32 0.268 P00451 A1939T Disease 0.444 0.535 0.00 52 0.538 P00451 A1939V Disease 0.494 0.604 0.00 55 0.670 P00451 A2058P Disease 0.645 0.920 0.00 55 0.913 P00451 A2070V Disease 0.494 0.887 0.00 52 0.821 P00451 A2211P Disease 0.869 0.893 0.00 53 0.892 P00451 A2220P Disease 0.444 0.837 0.02 49 0.757 P00451 C1877R Disease 0.974 0.827 0.00 64 0.953 P00451 C2040Y Disease 0.952 0.944 0.01 71 0.943 P00451 C2193G Disease 0.866 0.846 0.01 62 0.898 P00451 C2345S Disease NA 0.948 0.00 61 0.924 P00451 C2345Y Disease NA 0.944 0.00 70 0.934 P00451 D1727V Disease NA 0.755 0.00 51 0.853 P00451 D1788H Disease 0.731 0.899 0.00 52 0.903 P00451 D1865N Disease 0.911 0.881 0.00 54 0.913 P00451 D1865Y Disease 0.979 0.922 0.00 64 0.961 P00451 D2093G Disease 0.822 0.935 0.02 64 0.940 P00451 D2093Y Disease 0.945 0.906 0.00 69 0.930 P00451 D2307A Disease 0.568 0.773 0.02 59 0.811 P00451 E1057K Disease NA 0.202 0.00 36 0.211 P00451 E1701K Disease NA 0.160 0.22 47 0.280 P00451 E1723K Disease NA 0.897 0.00 59 0.819 P00451 E1848G Disease 0.554 0.566 0.52 33 0.476 P00451 E1894G Disease 0.554 0.859 0.00 47 0.878 P00451 E1904D Disease 0.861 0.745 0.00 32 0.877 P00451 E1904K Disease 0.929 0.870 0.00 49 0.901 P00451 E2018G Disease 0.554 0.313 0.78 62 0.770 P00451 E2200D Disease 0.201 0.764 0.03 35 0.353 P00451 F1804S Disease 0.670 0.370 0.00 29 0.614 P00451 F1982I Disease 0.256 0.560 0.01 56 0.532 P00451 F2120C Disease 0.835 0.870 0.00 57 0.934 P00451 F2120L Disease 0.355 0.830 0.02 49 0.804 P00451 F2145C Disease 0.776 0.935 0.00 68 0.942 P00451 F2279C Disease 0.841 0.733 0.00 55 0.889 P00451 F2279I Disease 0.528 0.681 0.00 50 0.801 P00451 G1769R Disease 0.768 0.191 0.22 41 0.540 P00451 G1779E Disease 0.971 0.881 0.00 60 0.959 P00451 G1779R Disease 0.976 0.867 0.00 63 0.957 P00451 G1869D Disease 0.968 0.879 0.00 72 0.956 P00451 G1869V Disease 0.975 0.787 0.00 63 0.954 P00451 G1872E Disease 0.969 0.879 0.00 67 0.959 P00451 G1942A Disease 0.932 0.830 0.00 55 0.941 P00451 G1967D Disease 0.968 0.906 0.00 73 0.950 P00451 G1979V Disease 0.482 0.756 0.00 57 0.860 P00451 G2000A Disease 0.539 0.320 0.07 55 0.653 P00451 G2022D Disease 0.703 0.442 0.01 65 0.851 P00451 G2028R Disease 0.975 0.868 0.01 71 0.954 P00451 G2045E Disease 0.912 0.944 0.00 64 0.952 P00451 G2045V Disease 0.927 0.871 0.02 50 0.898 P00451 G2107S Disease 0.372 0.888 0.00 61 0.898 P00451 G2198V Disease 0.935 0.860 0.00 48 0.909 P00451 G2304V Disease 0.512 0.841 0.00 60 0.817 P00451 G2344C Disease NA 0.921 0.00 57 0.748 P00451 G2344S Disease NA 0.874 0.01 57 0.737 P00451 H1066Y Disease NA 0.259 0.00 11 0.134 P00451 H1867P Disease 0.516 0.429 0.02 71 0.789 P00451 H1867R Disease 0.298 0.226 0.03 63 0.425 P00451 H1973L Disease 0.361 0.472 0.58 67 0.491 P00451 H1980P Disease 0.440 0.589 0.01 56 0.671 P00451 H1980Y Disease 0.331 0.444 0.32 56 0.542 P00451 H2174D Disease NA 0.420 0.50 70 0.286 P00451 I1698T Disease NA 0.167 0.19 -1 0.219 P00451 I1782R Disease 0.914 0.783 0.00 50 0.922 P00451 I1901F Disease 0.456 0.492 0.00 47 0.751 P00451 I2051S Disease 0.626 0.905 0.00 53 0.900 P00451 I2056N Disease 0.757 0.909 0.00 54 0.919 P00451 I2117F Disease 0.483 0.805 0.01 51 0.879 P00451 I2117S Disease 0.578 0.692 0.01 42 0.834 P00451 I2204T Disease 0.814 0.821 0.01 50 0.776 P00451 I2209N Disease 0.678 0.810 0.00 54 0.855 P00451 I2281T Disease 0.411 0.409 0.00 49 0.664 P00451 K1289Q Polymorphism NA 0.238 0.15 26 0.143 P00451 K1751Q Disease NA 0.832 0.00 48 0.864 P00451 K1864E Disease 0.319 0.521 0.00 49 0.562 P00451 L1771P Disease 0.803 0.322 0.08 36 0.552 P00451 L1775F Disease 0.879 0.603 0.02 51 0.889 P00451 L1775V Disease 0.845 0.635 0.02 50 0.884 P00451 L1777P Disease 0.774 0.690 0.00 29 0.747 P00451 L1808F Disease 0.472 0.295 0.22 45 0.508 P00451 L1875P Disease 0.752 0.712 0.00 32 0.848 P00451 L1882P Disease 0.803 0.874 0.00 29 0.868 P00451 L1951F Disease 0.872 0.767 0.00 51 0.841 P00451 L1963P Disease 0.937 0.925 0.00 46 0.913 P00451 L1994P Disease 0.500 0.602 0.00 40 0.788 P00451 L2185S Disease NA 0.787 0.00 48 0.849 P00451 L2185W Disease NA 0.807 0.00 56 0.886 P00451 L2229F Disease 0.508 0.839 0.00 49 0.737 P00451 M1791T Disease 0.106 0.374 0.43 28 0.143 P00451 M1842I Disease 0.251 0.115 0.07 46 0.253 P00451 M1945V Disease 0.120 0.224 0.06 58 0.201 P00451 M1966I Disease 0.165 0.457 0.20 57 0.257 P00451 M1966V Disease 0.115 0.399 0.38 58 0.237 P00451 M2007I Disease 0.322 0.728 0.01 50 0.625 P00451 M2183R Disease NA 0.876 0.00 59 0.902 P00451 M2183V Disease NA 0.620 0.12 45 0.526 P00451 M2257V Disease 0.067 0.396 0.12 25 0.112 P00451 N1460K Disease NA 0.390 0.01 12 0.216 P00451 N1941D Disease 0.900 0.918 0.00 66 0.945 P00451 N1941S Disease 0.915 0.878 0.00 56 0.916 P00451 N1971T Disease 0.272 0.259 0.00 53 0.310 P00451 N2038S Disease 0.072 0.235 0.58 31 0.180 P00451 N2148S Disease 0.382 0.892 0.02 58 0.840 P00451 N2157D Disease NA 0.711 0.00 56 0.737 P00451 P1780L Disease 0.997 0.778 0.00 1 0.893 P00451 P1801A Disease 0.860 0.589 0.00 40 0.799 P00451 P1844S Disease 0.882 0.842 0.01 39 0.871 P00451 P1873R Disease 0.933 0.600 0.00 55 0.914 P00451 P2067L Disease 0.728 0.915 0.00 46 0.880 P00451 P2162L Disease NA 0.897 0.00 49 0.820 P00451 P2172Q Disease NA 0.774 0.00 57 0.865 P00451 P2172R Disease NA 0.872 0.00 65 0.917 P00451 P2196R Disease 0.937 0.863 0.01 67 0.760 P00451 P2224L Disease 0.934 0.907 0.00 51 0.932 P00451 P2319L Disease 0.934 0.756 0.00 50 0.877 P00451 P2319S Disease 0.888 0.597 0.03 55 0.854 P00451 Q1336K Disease NA 0.224 0.02 7 0.146 P00451 Q1705H Disease NA 0.197 0.06 9 0.247 P00451 Q2106E Disease 0.294 0.921 0.00 64 0.926 P00451 Q2106R Disease 0.322 0.935 0.00 67 0.902 P00451 Q2119R Disease 0.285 0.781 0.04 52 0.601 P00451 Q2265R Disease 0.794 0.827 0.01 67 0.778 P00451 Q2330P Disease 0.362 0.767 0.03 47 0.671 P00451 R1708C Disease NA 0.918 0.01 64 0.873 P00451 R1708H Disease NA 0.594 0.00 58 0.573 P00451 R1715G Disease NA 0.974 0.02 43 0.863 P00451 R1740G Disease NA 0.551 0.06 48 0.504 P00451 R1768H Disease 0.487 0.487 0.00 50 0.554 P00451 R1800C Disease 0.983 0.941 0.00 47 0.932 P00451 R1800G Disease 0.944 0.945 0.00 37 0.916 P00451 R1800H Disease 0.963 0.800 0.00 34 0.878 P00451 R1888I Disease 0.495 0.479 0.01 51 0.625 P00451 R1960L Disease 0.622 0.358 0.04 52 0.648 P00451 R1960Q Disease 0.535 0.299 0.09 51 0.607 P00451 R1985Q Disease 0.311 0.425 0.27 61 0.419 P00451 R2016P Disease 0.522 0.686 0.08 63 0.733 P00451 R2016W Disease 0.773 0.592 0.02 66 0.878 P00451 R2109C Disease 0.816 0.792 0.01 62 0.809 P00451 R2135P Disease 0.571 0.823 0.02 52 0.803 P00451 R2169C Disease NA 0.927 0.00 69 0.928 P00451 R2169H Disease NA 0.883 0.00 71 0.917 P00451 R2178C Disease NA 0.762 0.00 68 0.895 P00451 R2178H Disease NA 0.566 0.04 68 0.568 P00451 R2178L Disease NA 0.791 0.01 62 0.836 P00451 R2182C Disease NA 0.940 0.00 68 0.940 P00451 R2182H Disease NA 0.934 0.00 69 0.940 P00451 R2182P Disease NA 0.953 0.00 63 0.941 P00451 R2228G Disease 0.878 0.896 0.00 59 0.819 P00451 R2228L Disease 0.888 0.902 0.01 58 0.887 P00451 R2228P Disease 0.920 0.937 0.01 61 0.894 P00451 R2228Q Disease 0.838 0.895 0.02 59 0.801 P00451 R2323C Disease 0.963 0.812 0.00 71 0.894 P00451 R2323G Disease 0.883 0.811 0.01 64 0.888 P00451 R2323H Disease 0.914 0.820 0.00 71 0.889 P00451 R2323L Disease 0.893 0.838 0.00 66 0.855 P00451 R2326G Disease 0.883 0.856 0.00 67 0.889 P00451 R2326L Disease 0.893 0.856 0.00 66 0.836 P00451 R2326P Disease 0.923 0.907 0.00 70 0.889 P00451 R2326Q Disease 0.844 0.882 0.00 68 0.748 P00451 R2339T Disease 0.891 0.940 0.00 67 0.895 P00451 S1799H Disease 0.926 0.791 0.00 33 0.886 P00451 S1803Y Disease 0.927 0.876 0.00 33 0.898 P00451 S1858C Disease 0.954 0.928 0.00 47 0.919 P00451 S1907C Disease 0.953 0.903 0.00 32 0.920 P00451 S1907R Disease 0.949 0.815 0.00 27 0.901 P00451 S1965I Disease 0.541 0.445 0.00 62 0.825 P00451 S1968R Disease 0.348 0.434 0.08 52 0.659 P00451 S2030N Disease 0.362 0.218 0.07 45 0.379 P00451 S2082N Disease 0.392 0.562 0.10 53 0.587 P00451 S2088F Disease NA 0.807 0.03 38 0.845 P00451 S2138Y Disease 0.738 0.627 0.00 52 0.741 P00451 S2192I Disease NA 0.381 0.03 52 0.466 P00451 T1714S Disease NA 0.301 0.44 27 0.363 P00451 T1845P Disease 0.517 0.635 0.33 33 0.785 P00451 T2004R Disease 0.605 0.705 0.00 72 0.777 P00451 T2105N Disease 0.464 0.877 0.00 56 0.895 P00451 T2141N Disease 0.418 0.429 0.64 50 0.313 P00451 T2173A Disease NA 0.393 0.04 55 0.470 P00451 T2173I Disease NA 0.530 0.05 52 0.514 P00451 T2264A Disease 0.685 0.665 0.01 55 0.854 P00451 V1012L Disease NA 0.288 0.42 -54 0.131 P00451 V1876L Disease 0.138 0.152 0.01 22 0.177 P00451 V2035A Disease 0.434 0.369 0.00 48 0.479 P00451 V2242M Polymorphism 0.342 0.268 0.06 49 0.390 P00451 V2251A Disease 0.443 0.573 0.03 46 0.652 P00451 V2251E Disease 0.718 0.779 0.00 66 0.865 P00451 W1908L Disease 0.956 0.760 0.00 55 0.921 P00451 W2015C Disease 0.878 0.917 0.00 68 0.942 P00451 W2065R Disease 0.933 0.909 0.00 69 0.931 P00451 W2248C Disease 0.996 0.857 0.00 66 0.958 P00451 W2248S Disease 0.994 0.795 0.00 58 0.952 P00451 W2290L Disease 0.896 0.873 0.00 69 0.888 P00451 W2332R Disease 0.943 0.906 0.01 76 0.885 P00451 Y1699C Disease NA 0.268 0.12 37 0.353 P00451 Y1699F Disease NA 0.191 0.12 9 0.201 P00451 Y1728C Disease NA 0.951 0.00 62 0.928 P00451 Y1802C Disease 0.828 0.851 0.00 51 0.893 P00451 Y1909C Disease 0.850 0.884 0.00 60 0.935 P00451 Y1998C Disease 0.820 0.584 0.00 68 0.909 P00451 Y2036C Disease 0.850 0.299 0.03 69 0.809 P00451 Y2124C Disease NA 0.940 0.00 64 0.832 P00480 E87K Disease NA 0.857 0.04 50 0.888 P00480 G39C Disease NA 0.915 0.07 46 0.879 P00480 G50R Disease NA 0.625 0.50 -12 0.325 P00480 G79E Disease NA 0.940 0.01 49 0.896 P00480 G83D Disease NA 0.816 0.01 54 0.898 P00480 G83R Disease NA 0.843 0.01 56 0.906 P00480 K88N Disease NA 0.841 0.02 30 0.837 P00480 L43F Polymorphism NA 0.923 0.00 56 0.920 P00480 L45P Disease NA 0.925 0.00 40 0.865 P00480 L45V Disease NA 0.618 0.14 0 0.479 P00480 L63P Disease NA 0.951 0.05 50 0.897 P00480 M56T Disease NA 0.730 0.00 25 0.793 P00480 N47I Disease NA 0.461 0.00 24 0.404 P00480 R26Q Disease NA 0.156 0.30 25 0.121 P00480 R40C Disease NA 0.891 0.00 62 0.924 P00480 R40H Disease NA 0.714 0.00 53 0.842 P00480 R92Q Disease NA 0.884 0.00 67 0.926 P00480 R94T Disease NA 0.912 0.00 65 0.930 P00480 S60L Disease NA 0.748 0.00 8 0.622 P00480 S90R Disease NA 0.853 0.00 67 0.923 P00480 T44I Disease NA 0.361 0.01 37 0.521 P00480 T93A Disease NA 0.815 0.00 56 0.906 P00480 Y55D Disease NA 0.716 0.62 -12 0.416 P00480 A102E Disease NA 0.472 0.27 -8 0.388 P00480 A140P Disease NA 0.873 0.04 16 0.775 P00480 A174P Disease 0.887 0.811 0.01 57 0.896 P00480 A208T Disease 0.369 0.650 0.06 31 0.558 P00480 A209V Disease 0.452 0.793 0.04 0 0.092 P00480 A336S Disease 0.394 0.885 0.01 7 0.563 P00480 C303R Disease 0.948 0.926 0.00 69 0.907 P00480 C303Y Disease 0.966 0.956 0.00 60 0.912 P00480 D126G Disease NA 0.923 0.00 70 0.877 P00480 D175V Disease 0.970 0.825 0.00 57 0.910 P00480 D196V Disease 0.548 0.881 0.00 66 0.684 P00480 D196Y Disease 0.823 0.876 0.00 70 0.757 P00480 D263G Disease 0.825 0.928 0.00 61 0.757 P00480 D263N Disease 0.749 0.915 0.00 59 0.712 P00480 E181G Disease 0.857 0.775 0.00 44 0.846 P00480 E326K Disease 0.643 0.836 0.01 53 0.852 P00480 F354C Disease 0.481 0.294 0.00 41 0.331 P00480 G100D Disease NA 0.858 0.00 49 0.865 P00480 G162R Disease NA 0.883 0.00 67 0.854 P00480 G188R Disease 0.528 0.902 0.00 39 0.761 P00480 G188V Disease 0.679 0.840 0.00 36 0.864 P00480 G195R Disease 0.949 0.861 0.00 73 0.771 P00480 G197E Disease 0.385 0.902 0.00 55 0.654 P00480 G197R Disease 0.297 0.883 0.00 59 0.646 P00480 G269E Disease 0.463 0.939 0.00 54 0.853 P00480 H117L Disease NA 0.591 0.01 42 0.799 P00480 H117R Disease NA 0.560 0.02 34 0.788 P00480 H168Q Disease NA 0.784 0.00 68 0.841 P00480 H168R Disease NA 0.774 0.00 72 0.841 P00480 H182L Disease 0.509 0.539 0.63 14 0.507 P00480 H202Y Disease 0.653 0.669 0.02 50 0.702 P00480 H214Y Disease 0.627 0.514 0.02 28 0.753 P00480 H255P Disease 0.230 0.775 0.06 26 0.437 P00480 H302L Disease 0.953 0.888 0.00 66 0.898 P00480 H302Q Disease 0.960 0.893 0.00 67 0.905 P00480 H302Y Disease 0.932 0.922 0.00 69 0.902 P00480 I159T Disease NA 0.389 0.00 31 0.500 P00480 I160S Disease NA 0.662 0.00 43 0.798 P00480 I172F Disease 0.528 0.235 0.08 26 0.606 P00480 I172M Disease 0.423 0.061 0.11 -26 0.146 P00480 L139S Disease NA 0.327 0.00 21 0.475 P00480 L148F Disease NA 0.524 0.01 35 0.786 P00480 L191F Disease 0.384 0.177 0.21 -11 0.209 P00480 L201P Disease 0.320 0.860 0.14 34 0.510 P00480 L244Q Disease 0.770 0.539 0.00 15 0.763 P00480 L301F Disease 0.702 0.597 0.01 46 0.831 P00480 L304F Disease 0.786 0.740 0.01 60 0.868 P00480 L341P Disease 0.836 0.891 0.00 59 0.933 P00480 M206I Disease 0.186 0.262 0.82 -42 0.154 P00480 M206R Disease 0.398 0.760 0.13 27 0.494 P00480 M213K Disease 0.650 0.930 0.01 45 0.792 P00480 M268T Disease 0.864 0.930 0.00 57 0.749 P00480 N161S Disease NA 0.876 0.00 55 0.752 P00480 N198K Disease 0.586 0.854 0.00 57 0.677 P00480 P220A Disease 0.930 0.857 0.00 61 0.766 P00480 P225L Disease 0.231 0.775 0.37 23 0.444 P00480 P225R Disease 0.620 0.909 0.03 45 0.873 P00480 P225T Disease 0.490 0.777 0.25 37 0.630 P00480 P305H Disease 0.982 0.831 0.00 65 0.909 P00480 Q180H Disease 0.309 0.108 0.52 -26 0.214 P00480 Q216E Disease 0.217 0.455 1.00 12 0.236 P00480 R129H Disease NA 0.868 0.09 19 0.521 P00480 R141P Disease NA 0.927 0.00 79 0.868 P00480 R141Q Disease NA 0.880 0.00 79 0.860 P00480 R277Q Disease 0.649 0.916 0.03 49 0.897 P00480 R277W Disease 0.946 0.933 0.00 49 0.921 P00480 R320L Disease 0.509 0.569 0.07 31 0.777 P00480 R330G Disease 0.924 0.904 0.00 57 0.911 P00480 S192R Disease 0.588 0.640 0.00 40 0.785 P00480 S203C Disease 0.926 0.885 0.00 49 0.816 P00480 S207R Disease 0.463 0.745 0.03 29 0.760 P00480 S267R Disease 0.803 0.913 0.00 57 0.761 P00480 S340P Disease 0.474 0.611 0.21 16 0.702 P00480 T125M Disease NA 0.302 0.09 -9 0.318 P00480 T178M Disease 0.921 0.782 0.00 51 0.889 P00480 T242I Disease 0.661 0.233 0.01 22 0.568 P00480 T247K Disease 0.595 0.811 0.07 60 0.911 P00480 T262K Disease 0.862 0.951 0.00 66 0.760 P00480 T264A Disease 0.458 0.650 0.07 48 0.774 P00480 T264I Disease 0.588 0.727 0.14 42 0.539 P00480 T333A Polymorphism 0.162 0.251 1.00 -26 0.212 P00480 T343K Disease 0.172 0.342 0.43 -30 0.164 P00480 V337L Disease 0.238 0.325 0.52 -37 0.262 P00480 V339L Disease 0.182 0.214 0.36 -46 0.193 P00480 W265L Disease 0.804 0.927 0.01 65 0.730 P00480 Y176C Disease 0.616 0.313 0.04 25 0.599 P00480 Y183C Disease 0.597 0.343 0.18 -5 0.497 P00480 Y183D Disease 0.593 0.472 0.20 -1 0.547 P00480 Y345C Disease 0.457 0.423 0.13 46 0.570 P00480 Y345D Disease 0.141 0.405 0.21 41 0.476 P00488 V35L Polymorphism NA 0.047 0.63 -43 0.053 P00488 V40I Polymorphism NA 0.074 0.25 -10 0.068 P00488 R682H Disease 0.578 0.138 0.20 -22 0.359 P00488 T551I Polymorphism 0.110 0.377 0.10 5 0.316 P00491 E89K Disease 0.778 0.943 0.08 66 0.938 P00491 G51S Polymorphism 0.392 0.312 0.73 -54 0.223 P00491 A174P Disease 0.788 0.899 0.06 48 0.880 P00491 D128G Disease 0.736 0.754 0.05 35 0.782 P00491 R234P Disease 0.778 0.796 0.14 0 0.791 P00491 Y192C Disease 0.950 0.925 0.01 62 0.936 P00492 G7D Disease 0.266 0.195 0.15 21 0.299 P00492 V8G Disease 0.619 0.228 0.00 32 0.512 P00492 A50P Disease 0.685 0.902 0.02 50 0.898 P00492 A50V Disease 0.544 0.857 0.01 25 0.734 P00492 D20V Disease 0.564 0.238 0.00 34 0.564 P00492 D80V Disease 0.618 0.459 0.04 10 0.622 P00492 F74L Disease 0.404 0.886 0.00 46 0.756 P00492 G16D Disease 0.668 0.484 0.06 47 0.715 P00492 G16S Disease 0.543 0.447 0.11 19 0.424 P00492 G58R Disease 0.805 0.908 0.46 0 0.692 P00492 G70E Disease 0.950 0.925 0.00 63 0.921 P00492 G71R Disease 0.599 0.918 0.04 64 0.917 P00492 I42F Disease 0.533 0.937 0.00 46 0.890 P00492 I42T Disease 0.489 0.810 0.00 37 0.822 P00492 L41P Disease 0.744 0.762 0.06 21 0.838 P00492 L78V Disease 0.758 0.869 0.01 29 0.601 P00492 M54L Disease 0.152 0.747 0.21 -15 0.209 P00492 M57T Disease 0.377 0.793 0.03 29 0.661 P00492 R45K Disease 0.411 0.790 0.45 11 0.431 P00492 R48H Disease 0.738 0.812 0.04 23 0.851 P00492 R51G Disease 0.505 0.811 0.31 6 0.468 P00492 R51P Disease 0.577 0.826 0.23 34 0.825 P00492 V53A Disease 0.359 0.652 0.00 23 0.652 P00492 V53M Disease 0.415 0.711 0.01 26 0.756 P00492 A161S Disease 0.316 0.779 0.02 30 0.533 P00492 C206Y Disease 0.783 0.812 0.03 1 0.781 P00492 D135G Disease 0.439 0.882 0.00 64 0.903 P00492 D177V Disease 0.653 0.899 0.00 59 0.903 P00492 D177Y Disease 0.752 0.922 0.00 63 0.920 P00492 D194E Disease 0.741 0.910 0.00 51 0.776 P00492 D194N Disease 0.827 0.904 0.00 56 0.757 P00492 D201G Disease 0.440 0.849 0.04 34 0.745 P00492 D201N Disease 0.326 0.604 0.69 -36 0.366 P00492 D201Y Disease 0.723 0.895 0.01 39 0.814 P00492 F199V Disease 0.472 0.810 0.01 43 0.832 P00492 H204D Disease 0.540 0.658 0.01 29 0.541 P00492 H204R Disease 0.515 0.772 0.01 41 0.830 P00492 I132M Disease 0.485 0.759 0.00 28 0.799 P00492 I132T Disease 0.494 0.811 0.00 25 0.811 P00492 I183T Disease 0.439 0.879 0.00 42 0.859 P00492 L131S Disease 0.717 0.865 0.00 40 0.855 P00492 M143K Disease 0.593 0.885 0.00 49 0.884 P00492 P176L Disease 0.495 0.786 0.04 21 0.545 P00492 S104R Disease 0.624 0.928 0.00 54 0.915 P00492 S110L Disease 0.536 0.881 0.01 36 0.860 P00492 S162R Disease 0.358 0.858 0.01 43 0.765 P00492 T168I Disease 0.252 0.475 0.02 -22 0.334 P00492 V130D Disease 0.793 0.865 0.00 57 0.908 P00492 Y195C Disease 0.836 0.920 0.00 57 0.843 P00505 A2S Polymorphism 0.053 0.178 0.00 -63 0.077 P00505 V428A Polymorphism 0.201 0.811 0.14 1 0.466 P00519 K247R Polymorphism 0.261 0.338 0.12 -8 0.297 P00519 P900S Polymorphism NA 0.212 0.19 33 0.249 P00519 S972L Polymorphism NA 0.096 0.08 23 0.048 P00533 R98Q Polymorphism 0.196 0.305 0.35 34 0.203 P00533 H988P Polymorphism 0.447 0.340 0.39 -3 0.268 P00533 P266R Polymorphism 0.662 0.652 0.01 33 0.700 P00533 R521K Polymorphism 0.074 0.082 0.32 26 0.105 P00533 R962G Polymorphism 0.614 0.334 0.17 46 0.506 P00533 V674I Polymorphism 0.122 0.078 0.24 24 0.098 P00533 A1210V Polymorphism NA 0.209 0.00 10 0.179 P00533 L1034R Polymorphism NA 0.293 0.00 38 0.350 P00558 C316R Disease 0.491 0.889 0.00 44 0.878 P00558 D164V Disease 0.926 0.938 0.00 61 0.935 P00558 D285V Disease 0.967 0.934 0.00 58 0.939 P00558 E252A Disease 0.401 0.283 0.35 -5 0.284 P00558 G158V Disease 0.384 0.812 0.00 28 0.659 P00558 R206P Disease 0.884 0.946 0.00 26 0.813 P00709 I46V Polymorphism 0.086 0.106 1.00 -6 0.092 P00734 P386T Polymorphism 0.726 0.109 0.40 -5 0.191 P00736 S152L Polymorphism NA 0.143 0.25 38 0.248 P00736 Y131H Polymorphism NA 0.388 0.22 40 0.325 P00739 N42H Polymorphism 0.166 0.562 0.19 21 0.311 P00739 R203K Polymorphism 0.106 0.132 0.73 -7 0.112 P00740 I7F Polymorphism NA 0.184 0.03 20 0.210 P00740 C28R Disease NA 0.651 0.49 58 0.762 P00740 C28Y Disease NA 0.657 0.40 47 0.548 P00740 C97S Disease 0.969 0.974 0.00 54 0.954 P00740 D93G Disease 0.849 0.923 0.00 51 0.792 P00740 E53A Disease 0.837 0.958 0.00 58 0.944 P00740 E54G Disease 0.971 0.969 0.00 44 0.940 P00740 E66V Disease 0.991 0.919 0.00 39 0.955 P00740 E67K Disease 0.978 0.828 0.00 38 0.852 P00740 E73K Disease 0.981 0.832 0.00 36 0.938 P00740 E73V Disease 0.992 0.869 0.00 48 0.927 P00740 E79D Disease 0.725 0.579 0.02 19 0.755 P00740 F55C Disease 0.714 0.703 0.01 50 0.879 P00740 F71S Disease 0.541 0.682 0.07 50 0.830 P00740 G58A Disease 0.420 0.850 0.03 38 0.699 P00740 G58R Disease 0.605 0.864 0.00 56 0.895 P00740 I17N Disease NA 0.388 0.02 24 0.427 P00740 K45N Disease 0.300 0.595 0.01 31 0.671 P00740 L52S Disease 0.681 0.887 0.00 57 0.907 P00740 N48I Disease 0.559 0.943 0.00 53 0.886 P00740 Q96P Disease 0.743 0.926 0.00 22 0.709 P00740 R43L Disease 0.163 0.952 0.00 32 0.725 P00740 R43Q Disease 0.174 0.940 0.00 46 0.784 P00740 R43W Disease 0.102 0.989 0.00 45 0.761 P00740 R46S Disease 0.472 0.986 0.00 -2 0.758 P00740 R46T Disease 0.511 0.969 0.00 21 0.803 P00740 R75Q Disease 0.851 0.708 0.13 49 0.790 P00740 S49P Disease 0.544 0.967 0.01 51 0.890 P00740 T84R Disease 0.934 0.938 0.00 61 0.946 P00740 V30I Disease NA 0.859 0.00 11 0.631 P00740 Y91C Disease 0.984 0.966 0.00 60 0.956 P00740 A265T Disease 0.895 0.742 0.00 26 0.721 P00740 A279T Disease 0.334 0.484 0.26 -4 0.261 P00740 A366D Disease 0.717 0.616 0.02 43 0.731 P00740 A397P Disease 0.975 0.861 0.00 57 0.906 P00740 A436V Disease 0.798 0.820 0.01 50 0.892 P00740 C102R Disease 0.986 0.947 0.00 65 0.955 P00740 C108S Disease 0.969 0.958 0.00 57 0.955 P00740 C119F Disease 0.989 0.970 0.00 62 0.956 P00740 C119R Disease 0.986 0.977 0.00 72 0.954 P00740 C134Y Disease 0.961 0.985 0.01 65 0.952 P00740 C155F Disease 0.988 0.977 0.00 66 0.955 P00740 C170F Disease 0.952 0.974 0.00 20 0.917 P00740 C178R Disease 0.984 0.881 0.02 37 0.951 P00740 C178W Disease 0.993 0.911 0.00 48 0.939 P00740 C252S Disease 0.992 0.887 0.00 70 0.945 P00740 C252Y Disease 0.997 0.948 0.00 77 0.945 P00740 C268W Disease 0.998 0.835 0.00 57 0.943 P00740 C382Y Disease 0.975 0.913 0.00 75 0.910 P00740 C396F Disease 0.970 0.919 0.00 71 0.893 P00740 C396S Disease 0.916 0.843 0.00 66 0.899 P00740 C407R Disease 0.991 0.873 0.00 78 0.925 P00740 C407S Disease 0.981 0.835 0.00 64 0.916 P00740 C435Y Disease 0.994 0.938 0.00 76 0.946 P00740 D110N Disease 0.821 0.716 0.00 23 0.711 P00740 D410H Disease 0.926 0.901 0.00 74 0.898 P00740 E124K Disease 0.187 0.500 0.05 40 0.434 P00740 E291V Disease 0.985 0.463 0.01 31 0.638 P00740 E433A Disease 0.823 0.352 0.01 42 0.607 P00740 E433K Disease 0.806 0.603 0.01 46 0.678 P00740 F395I Disease 0.850 0.296 0.03 27 0.587 P00740 F395L Disease 0.729 0.236 0.24 28 0.559 P00740 F424V Disease 0.618 0.536 0.01 42 0.580 P00740 G106D Disease 0.579 0.923 0.00 66 0.917 P00740 G106S Disease 0.333 0.878 0.02 44 0.775 P00740 G125E Disease 0.595 0.939 0.00 63 0.788 P00740 G125R Disease 0.623 0.928 0.00 70 0.934 P00740 G125V Disease 0.568 0.897 0.00 60 0.896 P00740 G139D Disease 0.982 0.946 0.02 58 0.968 P00740 G139S Disease 0.969 0.912 0.02 46 0.930 P00740 G160E Disease 0.375 0.940 0.03 53 0.867 P00740 G253E Disease 0.988 0.924 0.00 49 0.920 P00740 G253R Disease 0.989 0.899 0.00 35 0.947 P00740 G351D Disease 0.541 0.886 0.04 64 0.910 P00740 G357E Disease 0.989 0.889 0.00 70 0.922 P00740 G357R Disease 0.990 0.849 0.00 71 0.921 P00740 G363W Disease 0.951 0.844 0.00 53 0.920 P00740 G412E Disease 0.995 0.907 0.00 73 0.944 P00740 G413R Disease 0.944 0.887 0.00 68 0.893 P00740 G432S Disease 0.979 0.880 0.00 60 0.889 P00740 G432V Disease 0.990 0.882 0.00 69 0.892 P00740 G442E Disease 0.915 0.883 0.00 70 0.897 P00740 G442R Disease 0.935 0.838 0.00 71 0.894 P00740 H302R Disease 0.539 0.805 0.15 72 0.770 P00740 I112S Disease 0.595 0.522 0.00 33 0.522 P00740 I136T Disease 0.218 0.341 0.49 45 0.248 P00740 I316F Disease 0.621 0.754 0.00 38 0.822 P00740 I344L Disease NA 0.476 0.37 -33 0.266 P00740 I390F Disease 0.568 0.471 0.00 53 0.501 P00740 I443T Disease 0.544 0.401 0.01 32 0.632 P00740 I454T Disease 0.567 0.656 0.00 43 0.802 P00740 K362E Disease 0.190 0.320 0.03 6 0.151 P00740 K387E Disease 0.197 0.095 0.52 18 0.174 P00740 L318R Disease 0.797 0.771 0.00 60 0.890 P00740 L321Q Disease 0.984 0.712 0.00 59 0.913 P00740 L383F Disease 0.492 0.246 0.11 3 0.382 P00740 L383I Disease 0.337 0.084 0.20 -4 0.171 P00740 M394K Disease 0.987 0.938 0.00 67 0.922 P00740 N113K Disease 0.297 0.199 0.36 39 0.316 P00740 N283D Disease 0.107 0.248 0.98 7 0.191 P00740 N306S Disease 0.394 0.301 0.78 9 0.307 P00740 P101R Disease 0.979 0.905 0.00 56 0.948 P00740 P333H Disease 0.997 0.645 0.00 70 0.931 P00740 P333T Disease 0.995 0.500 0.00 50 0.875 P00740 P414T Disease 0.988 0.852 0.00 50 0.921 P00740 Q167H Disease 0.363 0.083 0.30 43 0.145 P00740 Q241H Disease 0.848 0.805 0.00 53 0.892 P00740 Q241K Disease 0.620 0.939 0.00 39 0.852 P00740 R191C Disease 0.618 0.535 0.04 64 0.671 P00740 R191H Disease 0.386 0.193 0.09 41 0.279 P00740 R226G Disease 0.890 0.846 0.00 -12 0.882 P00740 R226Q Disease 0.855 0.863 0.01 -29 0.829 P00740 R226W Disease 0.975 0.935 0.00 4 0.904 P00740 R294G Disease 0.442 0.219 0.13 50 0.447 P00740 R294Q Disease 0.288 0.246 0.22 46 0.343 P00740 R379G Disease 0.884 0.162 0.04 46 0.456 P00740 R379Q Disease 0.847 0.097 0.06 11 0.234 P00740 R404T Disease 0.312 0.479 0.01 27 0.278 P00740 R449Q Disease 0.310 0.090 0.40 2 0.185 P00740 R449W Disease 0.843 0.374 0.04 34 0.647 P00740 S169C Disease 0.679 0.708 0.00 -30 0.782 P00740 S411G Disease 0.757 0.792 0.00 53 0.877 P00740 S411I Disease 0.909 0.870 0.00 63 0.895 P00740 S430T Disease 0.722 0.765 0.00 65 0.876 P00740 T194A Polymorphism 0.058 0.239 0.76 -26 0.177 P00740 T342K Disease NA 0.740 0.04 15 0.597 P00740 T342M Disease NA 0.694 0.01 12 0.749 P00740 T426P Disease 0.881 0.721 0.01 30 0.838 P00740 V227D Disease 0.792 0.917 0.00 18 0.863 P00740 V227F Disease 0.540 0.878 0.00 43 0.849 P00740 V228F Disease 0.611 0.926 0.00 30 0.681 P00740 V228L Disease 0.282 0.787 0.00 16 0.453 P00740 V419E Disease 0.542 0.448 0.08 22 0.426 P00740 W356C Disease 0.912 0.874 0.00 76 0.897 P00740 W431G Disease 0.975 0.873 0.00 67 0.907 P00740 W431R Disease 0.986 0.929 0.00 71 0.922 P00740 W453R Disease 0.994 0.831 0.00 73 0.935 P00740 Y115C Disease 0.960 0.906 0.00 58 0.943 P00740 Y450C Disease 0.889 0.462 0.00 56 0.750 P00742 Q30H Polymorphism NA 0.157 0.09 -41 0.187 P00746 C214R Disease 0.623 0.896 0.00 72 0.879 P00746 V213G Disease 0.770 0.755 0.00 53 0.880 P00747 I46R Polymorphism NA 0.235 0.02 47 0.350 P00747 A620T Disease 0.461 0.849 0.00 25 0.533 P00747 K453I Polymorphism 0.295 0.163 0.07 12 0.301 P00747 R235H Disease NA 0.880 0.00 62 0.915 P00747 R408W Polymorphism 0.776 0.317 0.07 9 0.579 P00747 R523W Polymorphism 0.165 0.426 0.24 27 0.357 P00747 S591P Disease 0.640 0.780 0.03 34 0.798 P00747 V374F Disease NA 0.437 0.04 -27 0.316 P00748 Y53C Disease NA 0.444 0.00 62 0.687 P00748 A340G Polymorphism NA 0.415 0.16 -4 0.225 P00748 A411T Disease 0.825 0.720 0.09 52 0.725 P00748 C590S Disease 0.985 0.892 0.00 75 0.942 P00748 D461N Disease 0.905 0.865 0.00 -32 0.877 P00748 G589R Disease 0.861 0.919 0.02 70 0.857 P00748 L414M Disease 0.449 0.201 0.07 24 0.365 P00748 Q440K Disease 0.845 0.508 0.02 38 0.723 P00748 R142P Disease NA 0.597 0.18 47 0.636 P00748 R372P Disease 0.829 0.965 0.01 68 0.911 P00748 R417Q Disease NA 0.258 0.40 42 0.401 P00748 T328K Disease NA 0.183 0.25 -18 0.216 P00748 T328R Disease NA 0.224 0.29 1 0.362 P00748 W505C Disease 0.232 0.875 0.00 79 0.858 P00748 Y605H Polymorphism 0.735 0.551 0.00 61 0.695 P00749 I214M Polymorphism 0.293 0.464 0.00 57 0.700 P00749 P141L Polymorphism 0.086 0.090 1.00 -24 0.062 P00750 A146T Polymorphism NA 0.126 0.61 -6 0.226 P00750 R164W Polymorphism NA 0.657 0.08 50 0.691 P00751 L9H Polymorphism 0.437 0.356 0.00 33 0.251 P00751 R32Q Polymorphism 0.118 0.117 0.40 -5 0.077 P00751 W28Q Polymorphism 0.201 0.415 0.04 40 0.417 P00751 G252S Polymorphism 0.087 0.193 0.37 -37 0.114 P00797 D104N Disease 0.975 0.903 0.00 74 0.937 P00797 G217R Polymorphism 0.154 0.927 0.13 27 0.293 P00797 Q160K Polymorphism 0.242 0.858 0.74 -12 0.367 P00797 R230K Disease 0.420 0.475 0.22 14 0.411 P00813 D8N Polymorphism NA 0.117 1.00 -41 0.095 P00813 A83D Disease NA 0.825 0.00 52 0.891 P00813 G20R Disease NA 0.933 0.00 74 0.937 P00813 G74C Disease NA 0.533 0.10 33 0.483 P00813 H15D Disease NA 0.893 0.00 77 0.919 P00813 K80R Polymorphism NA 0.491 0.83 -39 0.285 P00813 R76W Disease NA 0.611 0.02 24 0.770 P00813 A179D Disease 0.910 0.804 0.01 56 0.921 P00813 A215T Disease 0.677 0.874 0.00 51 0.796 P00813 A329V Disease 0.905 0.596 0.01 42 0.812 P00813 G140E Disease 0.464 0.794 0.00 54 0.781 P00813 G216R Disease 0.861 0.956 0.00 67 0.936 P00813 L107P Disease NA 0.472 0.00 16 0.603 P00813 L304R Disease 0.921 0.767 0.00 72 0.917 P00813 P274L Disease 0.397 0.452 0.05 13 0.411 P00813 P297Q Disease 0.642 0.554 0.36 48 0.819 P00813 Q199P Disease 0.423 0.609 0.03 22 0.416 P00813 R101L Disease NA 0.825 0.00 57 0.896 P00813 R101Q Disease NA 0.691 0.00 63 0.806 P00813 R101W Disease NA 0.882 0.00 63 0.909 P00813 R149Q Disease 0.307 0.601 0.11 54 0.591 P00813 R149W Disease 0.578 0.846 0.01 62 0.896 P00813 R156C Disease 0.936 0.868 0.00 63 0.927 P00813 R156H Disease 0.829 0.797 0.00 50 0.916 P00813 R211C Disease 0.754 0.639 0.03 17 0.616 P00813 R211H Disease 0.766 0.442 0.02 23 0.641 P00813 S291L Disease 0.454 0.579 0.01 39 0.619 P00813 V129M Disease 0.609 0.789 0.00 32 0.622 P00813 V177M Disease 0.756 0.739 0.00 36 0.864 P00846 A7T Polymorphism 0.412 0.792 0.44 -48 0.426 P00846 A80T Polymorphism 0.409 0.120 0.12 -52 0.246 P00846 G16S Polymorphism 0.524 0.910 0.47 -14 0.498 P00846 H61Y Polymorphism 0.451 0.407 1.00 28 0.486 P00846 I14V Polymorphism 0.406 0.420 0.60 -22 0.402 P00846 L37P Polymorphism 0.875 0.929 0.13 48 0.902 P00846 T33S Polymorphism 0.278 0.189 0.83 -9 0.217 P00846 T53I Polymorphism 0.287 0.257 1.00 -14 0.168 P00846 A155T Polymorphism 0.472 0.708 0.57 -12 0.510 P00846 A177T Polymorphism 0.500 0.797 0.59 -16 0.463 P00846 I192T Disease 0.317 0.054 0.55 -51 0.095 P00846 I192V Polymorphism 0.348 0.127 0.53 -18 0.242 P00846 I204T Polymorphism NA 0.234 0.10 -29 0.357 P00846 L156P Disease 0.931 0.879 0.00 66 0.912 P00846 L156R Disease 0.880 0.887 0.00 67 0.914 P00846 L217P Disease NA 0.873 0.00 69 0.906 P00846 S182L Polymorphism 0.385 0.500 0.98 -47 0.295 P00846 T133A Polymorphism 0.611 0.408 0.25 53 0.626 P00915 A143V Polymorphism 0.841 0.926 0.07 4 0.700 P00918 H94Y Disease 0.883 0.940 0.00 66 0.871 P00918 Q92P Disease 0.922 0.957 0.00 58 0.920 P00918 G144R Disease 0.950 0.970 0.00 51 0.907 P00918 H107Y Disease 0.913 0.923 0.00 58 0.921 P00918 N252D Polymorphism 0.232 0.362 0.33 -14 0.224 P00966 C19R Disease 0.678 0.932 0.00 42 0.882 P00966 G14S Disease 0.915 0.937 0.00 58 0.932 P00966 P96H Disease 0.889 0.920 0.00 57 0.926 P00966 P96S Disease 0.623 0.894 0.00 39 0.859 P00966 Q40L Disease 0.813 0.889 0.00 37 0.868 P00966 R86C Disease 0.746 0.823 0.04 27 0.770 P00966 R86H Disease 0.543 0.795 0.14 13 0.712 P00966 R95S Disease 0.920 0.913 0.00 54 0.926 P00966 S18L Disease 0.920 0.934 0.00 44 0.889 P00966 S65I Polymorphism 0.427 0.742 0.00 -1 0.472 P00966 S79P Disease 0.480 0.910 0.00 20 0.850 P00966 V69A Disease 0.317 0.601 0.12 -25 0.456 P00966 A118T Disease 0.568 0.871 0.00 41 0.863 P00966 A192V Disease 0.694 0.777 0.00 26 0.855 P00966 A202E Disease 0.460 0.798 0.01 26 0.825 P00966 D124N Disease 0.871 0.910 0.00 60 0.928 P00966 D296G Disease 0.548 0.785 0.24 0 0.491 P00966 E191K Disease 0.788 0.939 0.00 63 0.936 P00966 E191Q Disease 0.833 0.815 0.00 57 0.925 P00966 E270Q Disease 0.809 0.795 0.00 60 0.923 P00966 E283K Disease 0.789 0.938 0.00 69 0.935 P00966 G117D Disease 0.950 0.932 0.00 65 0.932 P00966 G117S Disease 0.914 0.899 0.00 56 0.924 P00966 G280R Disease 0.702 0.947 0.00 56 0.917 P00966 G324S Disease 0.458 0.914 0.00 55 0.902 P00966 G324V Disease 0.853 0.919 0.00 64 0.926 P00966 G347R Disease 0.963 0.887 0.00 61 0.934 P00966 G362V Disease 0.775 0.915 0.00 48 0.884 P00966 G390R Disease 0.803 0.960 0.00 64 0.934 P00966 K277T Disease 0.911 0.866 0.00 57 0.927 P00966 K310Q Disease 0.550 0.805 0.00 51 0.888 P00966 K310R Disease 0.240 0.744 0.28 3 0.382 P00966 L160P Disease 0.680 0.901 0.00 20 0.863 P00966 L206P Disease 0.675 0.798 0.00 0 0.833 P00966 M302V Disease 0.352 0.887 0.00 20 0.599 P00966 R108L Disease 0.385 0.743 0.23 -22 0.416 P00966 R127Q Disease 0.895 0.920 0.00 64 0.930 P00966 R127W Disease 0.981 0.932 0.00 64 0.941 P00966 R157C Disease 0.975 0.917 0.00 58 0.956 P00966 R157H Disease 0.944 0.914 0.00 51 0.943 P00966 R265C Disease 0.945 0.901 0.01 52 0.926 P00966 R265H Disease 0.851 0.854 0.00 58 0.924 P00966 R272C Disease 0.941 0.889 0.00 65 0.930 P00966 R279Q Disease 0.898 0.909 0.00 64 0.927 P00966 R304W Disease 0.941 0.923 0.00 39 0.888 P00966 R307C Disease 0.612 0.801 0.18 -4 0.790 P00966 R363G Disease 0.764 0.905 0.00 53 0.908 P00966 R363L Disease 0.692 0.913 0.01 50 0.830 P00966 R363Q Disease 0.686 0.878 0.00 57 0.904 P00966 R363W Disease 0.945 0.913 0.00 58 0.931 P00966 S180N Disease 0.893 0.881 0.00 58 0.927 P00966 S341F Disease 0.532 0.853 0.03 36 0.779 P00966 T119I Disease 0.920 0.898 0.00 48 0.900 P00966 T284I Disease 0.515 0.878 0.00 33 0.866 P00966 T389I Disease 0.333 0.609 0.10 -11 0.475 P00966 V263M Disease 0.481 0.797 0.00 41 0.826 P00966 V269M Disease 0.821 0.822 0.01 37 0.749 P00966 V345G Disease 0.818 0.862 0.00 48 0.885 P00966 W179R Disease 0.890 0.844 0.00 50 0.925 P00966 Y190D Disease 0.672 0.794 0.01 37 0.846 P00966 Y291S Disease 0.376 0.790 0.13 -8 0.657 P00966 Y359D Disease 0.570 0.696 0.18 20 0.655 P00995 L12F Disease 0.458 0.143 0.12 -60 0.129 P00995 L14P Disease 0.771 0.488 0.01 -4 0.469 P00995 N34S Disease 0.108 0.058 0.83 -8 0.012 P00995 R67H Polymorphism 0.497 0.253 0.15 0 0.207 P01008 C32R Disease NA 0.422 0.00 49 0.659 P01008 F90L Disease NA 0.863 0.03 47 0.714 P01008 I39N Disease NA 0.299 0.00 44 0.484 P01008 L23P Disease NA 0.668 0.00 40 0.722 P01008 L98P Disease NA 0.934 0.00 52 0.902 P01008 P73L Disease NA 0.387 0.00 25 0.449 P01008 R56C Disease NA 0.333 0.00 26 0.295 P01008 R79C Disease NA 0.827 0.00 43 0.823 P01008 R79H Disease NA 0.357 0.00 3 0.337 P01008 R79S Disease NA 0.613 0.00 17 0.516 P01008 R89C Disease NA 0.731 0.04 18 0.764 P01008 V30E Polymorphism NA 0.688 0.02 54 0.824 P01008 Y17S Disease NA 0.141 0.13 -13 0.106 P01008 Y95C Disease NA 0.904 0.00 46 0.881 P01008 Y95S Disease NA 0.715 0.09 28 0.566 P01008 A414T Disease 0.364 0.933 0.03 42 0.743 P01008 A416P Disease 0.656 0.936 0.01 57 0.924 P01008 A416S Disease 0.387 0.821 0.01 21 0.561 P01008 A419V Disease 0.228 0.668 0.25 -3 0.345 P01008 A436T Disease 0.449 0.732 0.01 41 0.807 P01008 A459D Disease 0.538 0.736 0.18 8 0.747 P01008 C127R Disease NA 0.538 0.83 -42 0.303 P01008 C160Y Disease 0.830 0.534 0.15 4 0.731 P01008 C462F Disease NA 0.466 0.00 10 0.602 P01008 D398H Disease 0.569 0.408 0.05 9 0.577 P01008 E269K Disease 0.151 0.312 0.60 -12 0.218 P01008 E334K Disease 0.099 0.394 0.05 -10 0.243 P01008 F179L Disease 0.376 0.760 0.01 45 0.648 P01008 F261L Disease 0.997 0.889 0.00 57 0.906 P01008 F434C Disease 0.839 0.905 0.00 61 0.934 P01008 F434L Disease 0.361 0.781 0.10 29 0.572 P01008 F434S Disease 0.675 0.829 0.00 56 0.903 P01008 G424D Disease 0.714 0.621 0.33 32 0.663 P01008 G456R Disease 0.583 0.889 0.00 69 0.911 P01008 H152Y Disease 0.595 0.846 0.01 31 0.612 P01008 I251T Disease 0.545 0.458 0.03 44 0.670 P01008 I316N Disease 0.746 0.613 0.00 50 0.857 P01008 I453T Disease 0.468 0.595 0.00 28 0.765 P01008 K146E Disease 0.341 0.619 0.89 -6 0.365 P01008 L131F Disease NA 0.570 0.09 -3 0.485 P01008 L131V Disease NA 0.425 0.32 -6 0.419 P01008 L158P Disease 0.815 0.943 0.00 52 0.928 P01008 L178H Disease 0.841 0.734 0.00 58 0.912 P01008 L302P Disease 0.807 0.938 0.00 50 0.923 P01008 L441P Disease 0.806 0.877 0.00 32 0.866 P01008 M121K Disease NA 0.931 0.00 58 0.922 P01008 M283I Disease 0.114 0.802 0.00 53 0.698 P01008 M283V Disease 0.139 0.849 0.00 54 0.838 P01008 N167T Polymorphism 0.319 0.339 0.22 -29 0.303 P01008 N219D Disease 0.977 0.927 0.00 63 0.944 P01008 N219K Disease 0.987 0.928 0.00 64 0.946 P01008 N437K Disease 0.333 0.704 0.01 61 0.860 P01008 P112T Disease NA 0.819 0.01 61 0.897 P01008 P439L Disease 0.993 0.850 0.00 45 0.914 P01008 P439T Disease 0.992 0.822 0.00 49 0.930 P01008 P461L Disease 0.999 0.928 0.00 51 0.951 P01008 Q133K Disease NA 0.937 0.01 40 0.800 P01008 Q150P Disease 0.703 0.825 0.10 29 0.796 P01008 R161Q Disease 0.556 0.335 0.27 -27 0.472 P01008 R425C Disease 0.865 0.844 0.12 32 0.787 P01008 R425H Disease 0.708 0.795 0.07 31 0.794 P01008 R425P Disease 0.744 0.944 0.14 42 0.838 P01008 R438G Disease 0.500 0.716 0.03 55 0.860 P01008 R438M Disease 0.340 0.708 0.01 57 0.845 P01008 R457T Disease 0.625 0.883 0.00 44 0.883 P01008 S148P Disease 0.511 0.677 0.05 22 0.502 P01008 S214F Disease 0.707 0.815 0.01 36 0.849 P01008 S214Y Disease 0.735 0.655 0.01 37 0.807 P01008 S223P Disease 0.449 0.790 0.18 25 0.807 P01008 S323P Disease 0.112 0.750 0.13 4 0.092 P01008 S381P Disease 0.445 0.879 0.01 10 0.837 P01008 S397P Disease 0.622 0.879 0.02 51 0.894 P01008 S412R Disease 0.622 0.835 0.12 57 0.899 P01008 S426L Disease 0.608 0.820 0.30 39 0.758 P01008 T243I Disease 0.559 0.748 0.00 61 0.818 P01008 W257R Disease 0.767 0.910 0.03 82 0.909 P01008 Y198C Disease 0.853 0.864 0.00 67 0.928 P01008 Y198H Disease 0.631 0.631 0.00 74 0.852 P01009 T37A Polymorphism NA 0.101 0.88 -22 0.122 P01009 A360T Polymorphism 0.766 0.705 0.00 -7 0.659 P01009 R125H Polymorphism 0.173 0.224 0.44 -54 0.165 P01009 V237A Polymorphism 0.122 0.275 0.62 -18 0.122 P01011 A9T Polymorphism NA 0.263 0.16 -60 0.223 P01011 A167G Polymorphism 0.231 0.247 0.04 -18 0.298 P01011 D407G Polymorphism 0.123 0.533 0.62 11 0.124 P01011 K267R Polymorphism 0.312 0.468 0.07 6 0.281 P01019 E98K Polymorphism NA 0.167 0.09 33 0.171 P01019 G114C Polymorphism NA 0.289 0.01 33 0.417 P01019 L392M Polymorphism 0.228 0.615 0.01 35 0.500 P01019 M268I Polymorphism 0.192 0.153 0.08 12 0.173 P01019 R375Q Disease 0.317 0.625 0.02 41 0.552 P01019 T207M Polymorphism 0.546 0.260 0.15 44 0.492 P01023 C972Y Polymorphism 0.887 0.939 0.03 67 0.945 P01024 D549N Disease NA 0.683 0.28 44 0.614 P01024 P314L Polymorphism NA 0.082 0.21 33 0.196 P01024 R102G Polymorphism NA 0.151 0.13 18 0.220 P01024 R863K Polymorphism 0.126 0.241 0.76 3 0.246 P01024 G1224D Polymorphism 0.105 0.548 0.57 21 0.135 P01024 Q1521R Polymorphism 0.194 0.376 0.70 1 0.248 P01024 R1320Q Disease 0.429 0.318 0.29 1 0.318 P01031 F518S Polymorphism NA 0.161 0.34 22 0.157 P01031 R449G Polymorphism NA 0.171 0.40 19 0.234 P01031 V145I Polymorphism NA 0.161 0.61 -6 0.154 P01031 V802I Polymorphism 0.168 0.207 0.23 11 0.220 P01031 D1037N Polymorphism NA 0.444 0.30 -25 0.280 P01031 E1437D Polymorphism 0.319 0.212 0.65 -9 0.235 P01031 I1033T Polymorphism NA 0.177 0.61 17 0.144 P01031 S1310N Polymorphism 0.059 0.180 0.95 -16 0.070 P01034 L94Q Disease 0.859 0.579 0.02 36 0.777 P01036 D36N Polymorphism 0.267 0.500 0.24 23 0.414 P01037 P31L Polymorphism 0.451 0.297 0.50 -5 0.231 P01037 N129D Polymorphism 0.283 0.313 0.59 10 0.299 P01042 I197M Polymorphism 0.424 0.653 0.03 41 0.727 P01042 L212P Polymorphism 0.188 0.277 0.59 -1 0.161 P01042 M178T Polymorphism 0.130 0.037 0.65 17 0.018 P01106 N11S Polymorphism 0.568 0.490 0.00 42 0.656 P01106 A322V Polymorphism 0.126 0.147 0.63 -2 0.114 P01112 E63K Disease 0.174 0.655 0.04 56 0.576 P01112 G12A Disease 0.275 0.759 0.15 44 0.485 P01112 G12C Disease 0.643 0.929 0.01 49 0.742 P01112 G12E Disease 0.517 0.965 0.03 51 0.874 P01112 G12S Disease 0.319 0.630 1.00 8 0.390 P01112 G12V Disease 0.476 0.890 0.03 56 0.892 P01112 G13C Disease 0.863 0.961 0.00 43 0.873 P01112 G13D Disease 0.741 0.952 0.02 59 0.938 P01112 Q22K Disease 0.427 0.962 0.02 37 0.811 P01112 T58I Disease 0.765 0.865 0.00 57 0.913 P01112 A146T Disease NA 0.930 0.01 50 0.894 P01112 A146V Disease NA 0.893 0.00 45 0.834 P01112 K117R Disease NA 0.805 0.00 45 0.838 P01116 A59T Disease 0.446 0.889 0.01 55 0.642 P01116 G12D Disease 0.551 0.930 0.02 0 0.826 P01116 G12S Disease 0.319 0.623 1.00 -35 0.391 P01116 G12V Disease 0.476 0.892 0.03 34 0.852 P01116 G13D Disease 0.741 0.952 0.02 60 0.914 P01116 G60R Disease 0.910 0.899 0.00 62 0.927 P01116 P34R Disease 0.920 0.780 0.00 61 0.921 P01116 T58I Disease 0.765 0.865 0.00 56 0.912 P01116 V14I Disease 0.253 0.863 0.00 62 0.893 P01130 G2R Polymorphism NA 0.150 0.16 -54 0.151 P01130 A50S Disease 0.436 0.096 0.70 -7 0.200 P01130 C46S Disease 0.974 0.814 0.00 72 0.990 P01130 C89Y Disease 0.996 0.856 0.00 54 0.996 P01130 C95G Disease 0.993 0.762 0.00 53 0.991 P01130 D90N Disease 0.710 0.679 0.00 53 0.623 P01130 Q92E Disease 0.548 0.327 1.00 -17 0.434 P01130 R78C Disease 0.945 0.402 0.03 43 0.687 P01130 S56P Disease 0.968 0.354 0.01 41 0.748 P01130 A391T Polymorphism 0.714 0.061 1.00 -18 0.020 P01130 A399D Disease 0.651 0.729 0.01 43 0.732 P01130 C116R Disease 0.997 0.891 0.00 77 0.996 P01130 C160Y Disease 0.934 0.874 0.00 75 0.984 P01130 C173W Disease 0.988 0.771 0.00 73 0.993 P01130 C184Y Disease 0.846 0.829 0.00 56 0.970 P01130 C197R Disease 0.985 0.820 0.00 33 0.931 P01130 C231G Disease 0.802 0.795 0.00 48 0.852 P01130 C248Y Disease 0.987 0.846 0.00 71 0.992 P01130 C261F Disease 0.961 0.763 0.00 74 0.987 P01130 C276Y Disease 0.622 0.749 0.01 59 0.849 P01130 C302W Disease 0.996 0.782 0.00 58 0.993 P01130 C302Y Disease 0.985 0.826 0.00 51 0.993 P01130 C313Y Disease 0.994 0.842 0.01 66 0.989 P01130 C329Y Disease NA 0.950 0.00 57 0.866 P01130 C338S Disease 0.987 0.913 0.00 49 0.919 P01130 C368R Disease 0.996 0.868 0.00 75 0.991 P01130 C379Y Disease 0.999 0.913 0.00 44 0.948 P01130 D168N Disease 0.900 0.653 0.00 43 0.733 P01130 D168Y Disease 0.986 0.774 0.00 70 0.991 P01130 D175Y Disease 0.882 0.721 0.00 54 0.889 P01130 D221N Disease 0.880 0.646 0.00 61 0.782 P01130 D221Y Disease 0.992 0.743 0.00 68 0.993 P01130 D224V Disease 0.822 0.711 0.00 57 0.961 P01130 D301A Disease 0.964 0.629 0.00 43 0.862 P01130 D342N Disease 0.669 0.282 0.48 3 0.503 P01130 D356Y Disease 0.968 0.446 0.01 36 0.761 P01130 D482H Disease 0.993 0.861 0.00 72 0.953 P01130 D700E Disease 0.594 0.267 0.11 -13 0.543 P01130 E277K Disease 0.518 0.325 0.91 24 0.491 P01130 E288K Disease 0.446 0.262 0.42 21 0.286 P01130 E714K Disease 0.625 0.527 0.26 28 0.456 P01130 F403L Disease 0.535 0.875 0.00 13 0.564 P01130 H327Y Disease 0.814 0.780 0.00 35 0.708 P01130 I423T Disease 0.677 0.662 0.01 -11 0.675 P01130 L401V Disease 0.716 0.817 0.02 24 0.680 P01130 L414R Disease 0.940 0.841 0.01 26 0.905 P01130 L432V Disease 0.643 0.702 0.00 -14 0.585 P01130 L568V Disease 0.499 0.777 0.46 5 0.300 P01130 N564H Disease 0.952 0.838 0.00 62 0.948 P01130 P608S Disease 0.944 0.816 0.00 59 0.955 P01130 P649L Disease 0.948 0.750 0.00 46 0.893 P01130 Q366R Disease 0.958 0.640 0.00 41 0.861 P01130 R350P Disease 0.844 0.771 0.03 29 0.815 P01130 R416Q Disease 0.725 0.382 0.09 26 0.560 P01130 R416W Disease 0.968 0.693 0.01 14 0.753 P01130 R633C Disease 0.979 0.846 0.00 25 0.931 P01130 V797M Disease 0.552 0.377 0.07 -18 0.580 P01130 W483R Disease 0.996 0.883 0.00 74 0.943 P01133 D981E Polymorphism 0.477 0.435 0.72 41 0.391 P01133 E920V Polymorphism 0.274 0.282 0.54 32 0.225 P01133 G723R Polymorphism 0.637 0.559 0.31 64 0.508 P01133 L292H Polymorphism 0.535 0.254 0.11 47 0.597 P01133 R431K Polymorphism 0.088 0.155 1.00 -5 0.125 P01133 A1084G Polymorphism 0.160 0.086 0.19 0 0.049 P01133 L1043F Polymorphism 0.587 0.270 0.13 -29 0.413 P01133 P1070L Disease 0.469 0.222 0.03 0 0.209 P01135 V109M Polymorphism 0.351 0.283 0.05 24 0.228 P01137 L10P Polymorphism 0.072 0.343 1.00 13 0.175 P01137 R25P Polymorphism 0.477 0.226 0.25 -19 0.357 P01137 Y81H Disease 0.873 0.791 0.00 62 0.791 P01137 C225R Disease 0.950 0.876 0.41 3 0.850 P01137 H222D Disease 0.893 0.694 0.39 30 0.797 P01137 R218C Disease 0.748 0.582 0.02 12 0.767 P01137 R218H Disease 0.405 0.237 0.06 -40 0.376 P01138 R221W Disease 0.989 0.934 0.00 61 0.964 P01148 W16S Polymorphism 0.079 0.214 0.57 4 0.146 P01185 A19T Disease 0.618 0.852 0.01 51 0.883 P01185 A19V Disease 0.683 0.788 0.01 50 0.874 P01185 A99P Disease 0.788 0.926 0.01 30 0.858 P01185 C52R Disease 0.900 0.940 0.00 78 0.945 P01185 C58F Disease 0.907 0.966 0.00 73 0.944 P01185 C59R Disease 0.900 0.979 0.00 79 0.944 P01185 C59Y Disease 0.925 0.975 0.00 73 0.948 P01185 C92S Disease 0.753 0.875 0.00 63 0.917 P01185 C92Y Disease 0.916 0.924 0.00 71 0.941 P01185 C98G Disease 0.775 0.942 0.00 60 0.936 P01185 C98S Disease 0.753 0.931 0.00 59 0.934 P01185 E78G Disease 0.743 0.824 0.00 51 0.896 P01185 G45R Disease 0.899 0.940 0.00 68 0.945 P01185 G48V Disease 0.666 0.541 0.01 23 0.664 P01185 G54R Disease 0.899 0.953 0.00 66 0.945 P01185 G54V Disease 0.888 0.960 0.00 60 0.942 P01185 G88R Disease 0.754 0.837 0.01 30 0.728 P01185 G88S Disease 0.293 0.720 0.03 18 0.493 P01185 G93W Disease 0.967 0.865 0.00 55 0.958 P01185 G96C Disease 0.920 0.876 0.00 55 0.933 P01185 G96D Disease 0.850 0.883 0.01 60 0.929 P01185 G96V Disease 0.876 0.898 0.00 58 0.930 P01185 L81P Disease 0.897 0.932 0.02 29 0.895 P01185 P26L Disease 0.876 0.864 0.00 45 0.893 P01185 P55L Disease 0.885 0.834 0.00 46 0.889 P01185 P82L Polymorphism 0.192 0.475 0.10 13 0.310 P01185 R51C Disease 0.935 0.770 0.00 48 0.892 P01185 R97C Disease 0.871 0.756 0.03 51 0.902 P01185 R97P Disease 0.761 0.921 0.11 41 0.842 P01185 S17F Disease 0.629 0.761 0.01 0 0.789 P01185 S87F Disease 0.540 0.600 0.03 27 0.726 P01185 V67A Disease 0.494 0.355 0.03 35 0.519 P01185 Y21H Disease 0.777 0.860 0.00 76 0.916 P01185 C104F Disease 0.897 0.958 0.00 64 0.945 P01185 C104G Disease 0.775 0.966 0.00 55 0.923 P01185 C105R Disease 0.889 0.972 0.00 70 0.941 P01185 C105Y Disease 0.916 0.976 0.00 68 0.945 P01185 C116G Disease 0.775 0.945 0.00 64 0.914 P01185 C116R Disease 0.889 0.957 0.00 76 0.942 P01185 C116W Disease 0.960 0.967 0.00 72 0.965 P01185 G119V Polymorphism 0.616 0.348 0.03 4 0.581 P01189 S7T Polymorphism 0.322 0.088 0.00 -36 0.173 P01189 S9L Polymorphism 0.477 0.267 0.00 -45 0.202 P01189 E214G Polymorphism 0.362 0.196 0.07 15 0.325 P01189 P132A Polymorphism 0.251 0.058 0.55 6 0.139 P01189 R236G Polymorphism 0.810 0.901 0.00 55 0.943 P01210 G247D Polymorphism 0.180 0.331 0.22 23 0.377 P01225 C69G Disease 0.913 0.968 0.00 69 0.949 P01225 S20I Polymorphism 0.698 0.191 0.18 25 0.251 P01229 A18T Polymorphism 0.113 0.129 0.32 -28 0.097 P01229 Q74R Disease 0.938 0.934 0.00 51 0.950 P01233 F4L Polymorphism 0.140 0.106 1.00 -79 0.109 P01233 K22R Polymorphism 0.145 0.060 1.00 -75 0.101 P01233 R28W Polymorphism 0.067 0.224 0.19 -10 0.095 P01233 T18A Polymorphism 0.113 0.149 1.00 -78 0.098 P01241 T3A Disease 0.101 0.033 1.00 -84 0.043 P01241 D37N Disease 0.252 0.557 1.00 -15 0.365 P01241 K67R Disease 0.090 0.115 1.00 -10 0.102 P01241 L16P Disease 0.669 0.823 0.00 58 0.906 P01241 N73D Disease 0.155 0.207 0.77 25 0.181 P01241 R42C Disease 0.835 0.711 0.00 57 0.907 P01241 S97F Disease 0.827 0.850 0.00 46 0.879 P01241 T53I Disease 0.192 0.234 0.41 1 0.205 P01241 D138G Disease 0.182 0.577 0.01 -4 0.455 P01241 E100K Disease 0.233 0.238 0.71 7 0.270 P01241 Q117L Disease 0.235 0.474 0.00 0 0.320 P01241 R103C Disease 0.833 0.510 0.00 12 0.749 P01241 R209H Disease 0.863 0.953 0.00 61 0.929 P01241 S134C Disease 0.767 0.457 0.03 25 0.659 P01241 S134R Disease 0.349 0.707 0.08 16 0.535 P01241 T201A Disease 0.399 0.687 0.00 28 0.592 P01242 R90W Polymorphism 0.787 0.424 0.00 44 0.661 P01258 G2R Polymorphism 0.527 0.638 0.14 0 0.615 P01258 S76R Polymorphism 0.685 0.142 0.11 0 0.159 P01258 Q138P Polymorphism NA 0.309 0.32 5 0.199 P01258 S123T Polymorphism 0.120 0.036 0.26 -2 0.021 P01266 G653D Polymorphism NA 0.259 0.02 45 0.422 P01266 G815R Polymorphism NA 0.140 0.61 17 0.106 P01266 Q135H Polymorphism NA 0.105 0.02 42 0.157 P01266 Q830E Polymorphism NA 0.210 0.00 35 0.274 P01266 R988P Polymorphism NA 0.293 0.02 51 0.263 P01266 S734A Polymorphism NA 0.054 1.00 -26 0.033 P01266 C1264R Disease NA 0.336 0.00 72 0.658 P01266 C1996S Disease NA 0.714 0.00 33 0.759 P01266 D1312G Polymorphism NA 0.075 1.00 -12 0.017 P01266 D2091E Polymorphism NA 0.144 0.00 28 0.177 P01266 F2526L Polymorphism 0.178 0.340 0.04 22 0.288 P01266 I1059T Polymorphism NA 0.126 0.00 45 0.169 P01266 L1063M Polymorphism NA 0.176 0.01 38 0.393 P01266 L2469P Polymorphism 0.744 0.939 0.03 48 0.764 P01266 M1028V Polymorphism NA 0.066 0.15 19 0.066 P01266 N2616S Polymorphism 0.118 0.200 1.00 -16 0.145 P01266 Q2170R Polymorphism NA 0.163 0.02 34 0.192 P01266 R1999W Polymorphism NA 0.208 0.01 -10 0.239 P01266 R2455H Polymorphism 0.617 0.873 0.00 26 0.753 P01266 W1437R Polymorphism NA 0.254 0.24 36 0.086 P01266 W2501R Polymorphism 0.093 0.657 0.35 17 0.064 P01270 C18R Disease 0.350 0.578 0.02 52 0.652 P01270 S23P Disease 0.414 0.096 0.03 -1 0.133 P01298 E78G Polymorphism 0.289 0.083 0.10 9 0.061 P01303 L22M Polymorphism 0.649 0.181 0.02 17 0.354 P01308 H34D Disease 0.714 0.966 0.11 17 0.724 P01308 R89H Disease 0.602 0.678 0.00 59 0.816 P01308 R89L Disease 0.515 0.875 0.00 57 0.895 P01374 H51P Polymorphism 0.144 0.615 0.28 15 0.318 P01375 A94T Polymorphism 0.344 0.510 0.04 36 0.680 P01375 P84L Polymorphism 0.236 0.123 0.13 0 0.200 P01562 A137V Polymorphism 0.181 0.134 0.17 -8 0.202 P01566 G42A Polymorphism 0.202 0.155 0.79 -22 0.115 P01568 K179E Polymorphism 0.151 0.081 0.14 3 0.084 P01568 L119M Polymorphism 0.860 0.855 0.00 45 0.868 P01571 I184R Polymorphism 0.694 0.058 1.00 -30 0.018 P01579 K29Q Polymorphism 0.461 0.192 0.17 13 0.318 P01579 R160Q Polymorphism 0.178 0.079 0.16 41 0.083 P01583 R85Q Polymorphism 0.561 0.339 0.37 33 0.370 P01583 D138N Polymorphism 0.520 0.756 0.00 62 0.880 P01583 D176H Polymorphism 0.541 0.119 0.12 35 0.158 P01730 F227S Polymorphism 0.821 0.804 0.00 46 0.881 P01730 K191E Polymorphism 0.492 0.380 0.53 33 0.253 P01730 R265W Polymorphism 0.824 0.096 0.01 44 0.275 P01732 G111S Disease 0.913 0.777 0.02 48 0.908 P01833 G365S Polymorphism 0.183 0.861 0.23 53 0.411 P01871 G191S Polymorphism NA 0.048 1.00 -15 0.016 P01877 D296E Polymorphism 0.337 0.109 1.00 25 0.154 P01877 F279Y Polymorphism 0.120 0.469 1.00 12 0.242 P01877 P102R Polymorphism 0.448 0.531 0.20 54 0.615 P01877 V335A Polymorphism NA 0.071 0.76 32 0.082 P01889 V9L Polymorphism 0.206 0.258 1.00 -81 0.169 P01889 A65T Polymorphism 0.254 0.320 0.08 -11 0.354 P01889 D98Y Polymorphism 0.197 0.522 0.93 4 0.343 P01889 L17V Polymorphism 0.352 0.811 0.35 -52 0.621 P01889 N87D Polymorphism 0.328 0.410 0.20 30 0.571 P01889 N87K Polymorphism 0.266 0.680 0.19 36 0.696 P01889 S35A Polymorphism 0.507 0.131 1.00 -23 0.143 P01889 T97A Polymorphism 0.412 0.226 0.19 -1 0.342 P01889 A329T Polymorphism 0.280 0.291 0.65 -53 0.330 P01889 D138N Polymorphism 0.304 0.462 0.64 -5 0.253 P01889 E187A Polymorphism 0.367 0.346 0.76 26 0.386 P01889 E187G Polymorphism 0.577 0.349 0.40 34 0.620 P01889 E187L Polymorphism 0.399 0.412 0.50 24 0.387 P01889 R155S Polymorphism 0.255 0.763 0.56 -3 0.502 P01889 R180D Polymorphism 0.278 0.548 0.35 14 0.297 P01889 S101N Polymorphism 0.295 0.144 1.00 -29 0.141 P01889 S121R Polymorphism 0.359 0.547 0.51 6 0.357 P01891 D98H Polymorphism 0.474 0.826 0.50 14 0.630 P01891 R89G Polymorphism 0.477 0.804 0.06 10 0.591 P01891 T97I Polymorphism 0.292 0.264 0.40 -23 0.254 P01891 D101N Polymorphism 0.347 0.242 1.00 -38 0.235 P01891 D140H Polymorphism 0.271 0.318 0.32 13 0.323 P01891 H175L Polymorphism 0.293 0.580 0.14 0 0.321 P01891 R138E Polymorphism 0.247 0.391 0.91 6 0.232 P01891 R138H Polymorphism 0.382 0.625 0.61 -21 0.301 P01891 W180L Polymorphism 0.240 0.351 0.74 19 0.241 P01891 W180Q Polymorphism 0.193 0.274 0.47 16 0.179 P01892 A65G Polymorphism 0.377 0.356 0.03 -25 0.412 P01892 H94Q Polymorphism 0.229 0.159 0.64 -8 0.140 P01892 H98D Polymorphism 0.474 0.439 0.59 22 0.188 P01892 A173T Polymorphism 0.428 0.808 0.06 -8 0.577 P01892 A260E Polymorphism 0.530 0.561 0.64 26 0.759 P01892 E190D Polymorphism 0.444 0.750 0.10 -13 0.537 P01892 M162K Polymorphism 0.197 0.813 0.91 5 0.472 P01892 R121M Polymorphism 0.488 0.762 0.26 25 0.640 P01892 V119L Polymorphism 0.407 0.414 1.00 -31 0.226 P01892 V176E Polymorphism 0.244 0.487 0.38 10 0.419 P01892 W131G Polymorphism 0.626 0.228 1.00 10 0.210 P01892 Y123F Polymorphism 0.424 0.830 0.46 27 0.645 P01903 V16L Polymorphism NA 0.194 0.11 -49 0.202 P01903 V242L Polymorphism 0.196 0.127 0.98 -28 0.084 P01906 G247D Polymorphism NA 0.691 0.14 36 0.577 P01906 V227A Polymorphism 0.645 0.414 0.25 5 0.595 P01909 M8L Polymorphism NA 0.200 0.30 -78 0.152 P01909 A11T Polymorphism NA 0.211 0.21 -66 0.200 P01909 L91V Polymorphism 0.235 0.192 0.33 -13 0.175 P01909 Q57E Polymorphism 0.150 0.236 0.33 3 0.170 P01909 R64K Polymorphism 0.297 0.186 0.87 -32 0.155 P01909 R78S Polymorphism 0.363 0.328 1.00 -16 0.182 P01909 V17M Polymorphism NA 0.152 0.21 -52 0.134 P01909 Y48F Polymorphism 0.137 0.751 0.52 1 0.269 P01909 H151Q Polymorphism 0.163 0.325 0.61 -12 0.191 P01909 R240Q Polymorphism 0.138 0.796 0.39 31 0.254 P01911 K5R Polymorphism 0.057 0.224 0.87 -81 0.107 P01911 I96F Polymorphism 0.276 0.432 0.32 -9 0.318 P01911 A169T Polymorphism 0.268 0.545 0.51 -32 0.380 P01911 V115G Polymorphism 0.232 0.138 0.36 23 0.180 P01911 V236M Polymorphism 0.774 0.515 0.04 36 0.793 P01912 N106T Polymorphism 0.602 0.081 0.93 -34 0.057 P01912 T169A Polymorphism 0.268 0.068 0.56 -2 0.102 P01912 V236M Polymorphism 0.774 0.500 0.04 29 0.779 P01920 A6S Polymorphism NA 0.536 0.16 -70 0.456 P01920 E194D Polymorphism 0.683 0.929 0.53 48 0.886 P01920 P197L Polymorphism 0.489 0.931 0.18 24 0.654 P01920 V148I Polymorphism 0.459 0.651 0.38 15 0.479 P02144 E55K Polymorphism 0.241 0.264 0.02 50 0.405 P02144 K134N Polymorphism 0.414 0.583 0.00 22 0.472 P02144 R140Q Polymorphism 0.310 0.156 0.00 19 0.309 P02452 G224C Disease 0.998 0.722 0.00 59 0.976 P02452 G263R Disease 0.976 0.838 0.00 66 0.986 P02452 G272C Disease 0.925 0.813 0.00 63 0.968 P02452 G275D Disease 0.955 0.799 0.00 77 0.976 P02452 G332R Disease NA 0.857 0.00 65 0.989 P02452 G350R Disease NA 0.848 0.00 73 0.989 P02452 G353C Disease NA 0.708 0.00 62 0.943 P02452 G356C Disease NA 0.746 0.00 52 0.889 P02452 G383C Disease NA 0.601 0.00 61 0.896 P02452 G389R Disease NA 0.577 0.00 71 0.927 P02452 G398A Disease NA 0.525 0.00 52 0.778 P02452 G398D Disease NA 0.560 0.00 62 0.898 P02452 G401C Disease NA 0.628 0.00 63 0.916 P02452 G422C Disease NA 0.543 0.00 51 0.779 P02452 G425S Disease NA 0.500 0.00 63 0.923 P02452 G434V Disease NA 0.546 0.00 56 0.784 P02452 G476R Disease NA 0.511 0.00 74 0.926 P02452 G527C Disease NA 0.547 0.00 48 0.790 P02452 G533D Disease NA 0.577 0.00 73 0.929 P02452 G560C Disease NA 0.512 0.00 36 0.780 P02452 G560R Disease NA 0.500 0.00 66 0.924 P02452 G560S Disease NA 0.578 0.00 54 0.784 P02452 G569R Disease NA 0.530 0.00 41 0.792 P02452 G656S Disease 0.994 0.565 0.00 63 0.974 P02452 G701C Disease 0.995 0.481 0.00 60 0.885 P02452 G704C Disease 0.991 0.510 0.00 61 0.971 P02452 G719D Disease 0.998 0.523 0.00 67 0.985 P02452 G719S Disease 0.997 0.567 0.00 57 0.964 P02452 G728R Disease 0.994 0.514 0.00 75 0.990 P02452 G737D Disease 0.995 0.610 0.00 80 0.989 P02452 G743S Disease 0.970 0.562 0.00 58 0.958 P02452 G743V Disease 0.986 0.500 0.00 54 0.956 P02452 G764V Disease 0.903 0.586 0.00 66 0.964 P02452 G767S Disease 0.998 0.569 0.00 60 0.918 P02452 G776S Disease 0.976 0.563 0.00 58 0.925 P02452 G809S Disease 0.990 0.585 0.00 54 0.962 P02452 G815V Disease 0.995 0.626 0.00 66 0.979 P02452 G821S Disease 0.975 0.581 0.00 66 0.979 P02452 G839S Disease 0.987 0.552 0.00 63 0.973 P02452 G842R Disease 0.984 0.559 0.00 78 0.989 P02452 G845R Disease 0.999 0.579 0.00 76 0.984 P02452 G851D Disease 0.996 0.531 0.00 79 0.991 P02452 G866S Disease 0.993 0.540 0.00 63 0.933 P02452 G869C Disease 0.999 0.637 0.00 50 0.941 P02452 G896C Disease 0.986 0.556 0.00 57 0.964 P02452 G926C Disease 0.995 0.663 0.00 64 0.982 P02452 G980V Disease NA 0.851 0.00 58 0.973 P02452 R312C Disease NA 0.815 0.01 45 0.853 P02452 R564H Polymorphism NA 0.432 0.12 50 0.528 P02452 D1277H Disease NA 0.659 0.01 -8 0.639 P02452 G1010S Disease 0.985 0.826 0.00 54 0.986 P02452 G1022S Disease 0.984 0.802 0.00 55 0.923 P02452 G1022V Disease 0.993 0.771 0.00 63 0.979 P02452 G1025R Disease 0.981 0.829 0.00 74 0.988 P02452 G1043S Disease 0.967 0.778 0.00 64 0.941 P02452 G1049S Disease 0.998 0.669 0.00 60 0.930 P02452 G1058S Disease 0.802 0.706 0.00 62 0.950 P02452 G1061D Disease 0.985 0.767 0.00 74 0.989 P02452 G1061S Disease 0.975 0.740 0.00 68 0.979 P02452 G1076S Disease 0.986 0.597 0.00 62 0.939 P02452 G1082C Disease 0.997 0.615 0.00 72 0.988 P02452 G1088A Disease 0.997 0.627 0.00 59 0.930 P02452 G1091S Disease 0.998 0.640 0.00 60 0.921 P02452 G1106A Disease 0.962 0.768 0.00 52 0.918 P02452 G1124C Disease NA 0.607 0.00 60 0.830 P02452 G1142S Disease 0.998 0.682 0.00 63 0.972 P02452 G1151S Disease 0.994 0.767 0.00 66 0.981 P02452 G1151V Disease 0.997 0.651 0.00 65 0.977 P02452 G1154R Disease 0.996 0.841 0.00 74 0.991 P02452 G1166C Disease 0.997 0.747 0.00 64 0.971 P02452 G1172D Disease 0.998 0.665 0.00 74 0.969 P02452 G1181S Disease 0.998 0.531 0.00 53 0.885 P02452 G1184V Disease 0.996 0.412 0.00 54 0.825 P02452 G1187V Disease 0.996 0.439 0.00 65 0.943 P02452 G1195C Disease 0.171 0.384 0.08 30 0.322 P02452 L1388R Disease NA 0.795 0.02 -59 0.609 P02452 L1464P Disease NA 0.958 0.00 -7 0.807 P02452 R1014C Disease 0.922 0.571 0.05 32 0.790 P02452 R1141Q Polymorphism 0.305 0.449 0.10 56 0.426 P02452 V1177I Polymorphism 0.109 0.473 0.18 9 0.107 P02452 W1312C Disease NA 0.826 0.01 15 0.818 P02458 G267D Disease 0.993 0.840 0.00 41 0.921 P02458 G303D Disease 0.965 0.850 0.00 65 0.984 P02458 G318R Disease 0.906 0.888 0.00 73 0.975 P02458 G375R Disease NA 0.599 0.00 72 0.927 P02458 G447S Disease NA 0.567 0.04 63 0.918 P02458 G453D Disease NA 0.601 0.00 67 0.929 P02458 G453V Disease NA 0.579 0.00 64 0.927 P02458 G492V Disease NA 0.539 0.00 29 0.769 P02458 G510D Disease NA 0.594 0.00 73 0.927 P02458 G513S Disease NA 0.624 0.00 61 0.882 P02458 G717S Disease 0.994 0.596 0.00 57 0.964 P02458 G717V Disease 0.997 0.607 0.00 68 0.975 P02458 G771A Disease 0.988 0.464 0.00 64 0.931 P02458 G771D Disease 0.994 0.591 0.00 73 0.987 P02458 G774S Disease 0.990 0.536 0.00 69 0.983 P02458 G780R Disease 0.994 0.558 0.00 75 0.990 P02458 G795R Disease 0.996 0.532 0.00 72 0.991 P02458 G855S Disease 0.998 0.523 0.00 49 0.903 P02458 G891R Disease 0.998 0.583 0.00 68 0.977 P02458 G894E Disease 0.993 0.602 0.00 71 0.982 P02458 G897V Disease 0.935 0.672 0.00 61 0.960 P02458 G909C Disease 0.999 0.621 0.00 50 0.949 P02458 G948D Disease 0.993 0.874 0.00 76 0.992 P02458 G969S Disease 0.998 0.885 0.00 70 0.986 P02458 G981S Disease 0.948 0.824 0.00 64 0.924 P02458 L667F Disease 0.559 0.365 0.15 19 0.513 P02458 R565C Disease NA 0.695 0.20 20 0.758 P02458 R719C Disease 0.890 0.711 0.00 46 0.866 P02458 R904C Disease 0.894 0.792 0.01 53 0.938 P02458 R989C Disease NA 0.816 0.02 46 0.870 P02458 R992G Disease 0.773 0.755 0.06 29 0.743 P02458 T638I Polymorphism 0.425 0.430 0.24 0 0.345 P02458 A1051T Polymorphism 0.333 0.500 0.55 -10 0.384 P02458 C1485G Disease NA 0.972 0.00 18 0.828 P02458 D1469H Disease NA 0.806 0.00 50 0.721 P02458 G1017V Disease NA 0.772 0.00 48 0.863 P02458 G1065V Disease 0.985 0.802 0.00 65 0.957 P02458 G1110C Disease 0.999 0.604 0.00 61 0.965 P02458 G1119R Disease 0.299 0.804 0.00 73 0.897 P02458 G1143S Disease NA 0.781 0.00 59 0.907 P02458 G1170S Disease 0.958 0.741 0.00 64 0.936 P02458 G1173R Disease 0.996 0.795 0.00 74 0.983 P02458 G1176S Disease 0.994 0.761 0.00 66 0.979 P02458 G1188R Disease 0.994 0.781 0.00 71 0.978 P02458 G1197S Disease 0.998 0.767 0.00 56 0.906 P02458 G1405S Polymorphism NA 0.490 0.03 5 0.454 P02458 T1390N Disease NA 0.561 0.12 39 0.567 P02458 T1439M Disease NA 0.102 0.02 -7 0.245 P02458 T1448P Disease NA 0.825 0.00 33 0.839 P02458 Y1391C Disease NA 0.860 0.00 43 0.829 P02461 A679T Polymorphism NA 0.325 0.72 -12 0.260 P02461 G183C Disease 0.996 0.480 0.01 63 0.831 P02461 G183D Disease 0.995 0.559 0.02 71 0.977 P02461 G183S Disease 0.992 0.519 0.07 62 0.970 P02461 G192V Disease 0.993 0.626 0.01 62 0.964 P02461 G201R Disease 0.983 0.780 0.00 59 0.977 P02461 G204D Disease 0.992 0.806 0.00 64 0.985 P02461 G204S Disease 0.988 0.779 0.00 51 0.973 P02461 G210D Disease 0.984 0.706 0.00 64 0.980 P02461 G219C Disease 0.998 0.682 0.00 52 0.956 P02461 G225V Disease 0.995 0.781 0.00 45 0.923 P02461 G228E Disease 0.998 0.745 0.00 59 0.973 P02461 G240R Disease 0.994 0.799 0.00 74 0.986 P02461 G243V Disease 0.995 0.742 0.00 46 0.914 P02461 G249D Disease 0.487 0.812 0.01 72 0.985 P02461 G249V Disease 0.533 0.758 0.01 68 0.958 P02461 G252D Disease 0.984 0.804 0.00 78 0.984 P02461 G252R Disease 0.987 0.812 0.00 78 0.990 P02461 G252V Disease 0.988 0.758 0.00 70 0.985 P02461 G255V Disease NA 0.745 0.00 74 0.963 P02461 G264R Disease 0.973 0.865 0.00 67 0.983 P02461 G267V Disease 0.533 0.789 0.00 52 0.911 P02461 G297R Disease 0.995 0.889 0.00 71 0.992 P02461 G321V Disease 0.953 0.784 0.00 64 0.972 P02461 G327D Disease 0.941 0.741 0.00 73 0.981 P02461 G345R Disease 0.567 0.551 0.00 70 0.931 P02461 G417R Disease 0.999 0.513 0.00 72 0.984 P02461 G444R Disease 0.986 0.511 0.00 71 0.981 P02461 G489E Disease 0.997 0.470 0.00 75 0.945 P02461 G501R Disease 0.999 0.541 0.00 71 0.975 P02461 G519V Disease 0.995 0.493 0.00 62 0.966 P02461 G534E Polymorphism 0.999 0.580 0.00 76 0.985 P02461 G540R Disease 0.984 0.525 0.00 69 0.983 P02461 G549E Disease 0.996 0.424 0.00 70 0.933 P02461 G552E Disease 0.996 0.429 0.00 60 0.921 P02461 G567E Disease 0.998 0.438 0.00 68 0.942 P02461 G582S Disease 0.998 0.596 0.00 59 0.946 P02461 G588D Disease 0.977 0.547 0.00 74 0.986 P02461 G636R Disease 0.990 0.543 0.00 69 0.982 P02461 G657E Disease 0.971 0.436 0.00 70 0.942 P02461 G660D Disease 0.981 0.553 0.00 60 0.941 P02461 G666D Disease 0.972 0.538 0.00 63 0.953 P02461 G699R Disease NA 0.550 0.00 80 0.926 P02461 G726R Disease 0.988 0.555 0.00 67 0.984 P02461 G738S Disease 0.958 0.556 0.00 59 0.911 P02461 G738V Disease 0.981 0.529 0.00 62 0.970 P02461 G744V Disease 0.952 0.536 0.00 63 0.962 P02461 G756E Disease 0.982 0.619 0.00 73 0.987 P02461 G762C Disease 0.999 0.567 0.00 51 0.950 P02461 G786R Disease 0.988 0.616 0.00 68 0.983 P02461 G804S Disease 0.998 0.579 0.00 64 0.981 P02461 G828R Disease NA 0.519 0.00 72 0.928 P02461 G828W Disease NA 0.488 0.00 69 0.782 P02461 G852C Disease NA 0.583 0.00 68 0.930 P02461 G879V Disease NA 0.626 0.00 63 0.916 P02461 G882D Disease NA 0.527 0.00 73 0.927 P02461 G900D Disease NA 0.511 0.00 73 0.928 P02461 G903E Disease NA 0.741 0.00 62 0.941 P02461 G909D Disease NA 0.752 0.00 77 0.963 P02461 G909V Disease NA 0.756 0.00 63 0.961 P02461 G918E Disease NA 0.877 0.00 76 0.988 P02461 G924C Disease NA 0.891 0.00 57 0.973 P02461 G936R Disease NA 0.887 0.00 71 0.989 P02461 G936S Disease NA 0.857 0.00 52 0.816 P02461 G939D Disease NA 0.880 0.00 71 0.989 P02461 G942E Disease NA 0.885 0.00 73 0.989 P02461 G957S Disease NA 0.831 0.00 67 0.925 P02461 G960V Disease NA 0.864 0.00 65 0.989 P02461 G966V Disease NA 0.847 0.00 62 0.982 P02461 G972A Disease NA 0.855 0.00 58 0.852 P02461 G984T Disease NA 0.883 0.00 67 0.986 P02461 G996E Disease NA 0.840 0.00 72 0.988 P02461 G999R Disease NA 0.840 0.00 70 0.987 P02461 L169F Disease NA 0.384 0.21 1 0.341 P02461 P635L Polymorphism 0.500 0.319 0.29 17 0.424 P02461 G1011E Disease NA 0.770 0.00 42 0.837 P02461 G1014E Disease NA 0.770 0.00 59 0.921 P02461 G1032V Disease NA 0.828 0.00 64 0.981 P02461 G1035C Disease NA 0.804 0.00 53 0.912 P02461 G1044D Disease NA 0.793 0.00 71 0.964 P02461 G1050D Disease NA 0.718 0.00 66 0.956 P02461 G1050V Disease NA 0.677 0.00 54 0.821 P02461 G1071V Disease NA 0.573 0.00 64 0.923 P02461 G1077V Disease NA 0.513 0.00 62 0.892 P02461 G1089D Disease NA 0.708 0.00 65 0.952 P02461 G1098D Disease NA 0.735 0.00 58 0.901 P02461 G1098V Disease NA 0.764 0.00 56 0.902 P02461 G1101E Disease NA 0.698 0.00 48 0.853 P02461 G1104A Disease NA 0.781 0.00 37 0.652 P02461 G1161V Disease 0.999 0.607 0.00 29 0.838 P02461 G1164E Disease 0.993 0.763 0.00 60 0.960 P02461 G1164R Disease 0.994 0.774 0.00 60 0.963 P02461 G1167V Disease 0.997 0.669 0.00 52 0.952 P02461 G1170D Disease 0.996 0.687 0.00 57 0.960 P02461 G1170V Disease 0.997 0.628 0.00 33 0.841 P02461 G1173E Disease 0.999 0.701 0.00 50 0.959 P02461 G1173R Disease 0.998 0.722 0.00 61 0.973 P02461 G1176V Disease 0.997 0.603 0.00 56 0.960 P02461 G1179R Disease 0.998 0.605 0.05 61 0.955 P02461 G1182E Disease 0.998 0.518 0.27 68 0.968 P02461 G1185D Disease 0.995 0.517 0.36 49 0.907 P02461 G1185V Disease 0.996 0.477 0.17 31 0.775 P02461 G1188E Disease 0.996 0.536 0.08 56 0.951 P02461 G1188R Disease 0.996 0.528 0.06 53 0.946 P02461 H1353Q Polymorphism NA 0.253 1.00 -38 0.259 P02461 I1205V Polymorphism NA 0.256 0.29 -32 0.307 P02462 G498V Disease NA 0.872 0.00 36 0.880 P02462 G519R Disease NA 0.840 0.00 56 0.970 P02462 G528E Disease NA 0.859 0.05 41 0.866 P02462 G562E Disease NA 0.890 0.00 67 0.989 P02462 G749S Disease NA 0.839 0.00 56 0.970 P02462 G1130D Disease 0.790 0.856 0.00 72 0.979 P02462 G1236R Disease 0.999 0.828 0.00 64 0.990 P02462 G1423R Disease 0.998 0.664 0.00 72 0.969 P02489 R116C Disease 0.958 0.964 0.00 59 0.954 P02511 S41Y Polymorphism 0.259 0.479 1.00 12 0.434 P02511 R120G Disease 0.867 0.917 0.00 52 0.932 P02533 A94T Polymorphism 0.218 0.205 0.62 -22 0.205 P02533 A247D Disease 0.887 0.593 0.02 -36 0.804 P02533 A274D Disease 0.937 0.891 0.00 5 0.831 P02533 A413T Disease 0.558 0.779 0.21 -4 0.548 P02533 D273G Disease 0.894 0.907 0.02 34 0.886 P02533 E144A Disease 0.984 0.730 0.00 22 0.843 P02533 E215K Polymorphism 0.927 0.940 0.00 45 0.880 P02533 E422K Disease 0.758 0.734 0.01 43 0.837 P02533 I377N Disease 0.984 0.841 0.00 33 0.902 P02533 K116N Disease 0.950 0.944 0.00 43 0.895 P02533 L122F Disease 0.958 0.920 0.00 43 0.904 P02533 L130P Disease 0.986 0.940 0.00 49 0.933 P02533 L143P Disease 0.987 0.888 0.00 63 0.940 P02533 L384P Disease 0.987 0.873 0.00 48 0.915 P02533 L408M Disease 0.946 0.809 0.00 45 0.906 P02533 L419Q Disease 0.983 0.890 0.00 39 0.914 P02533 M119T Disease 0.981 0.923 0.00 39 0.913 P02533 M119V Disease 0.966 0.850 0.00 32 0.883 P02533 M272R Disease 0.961 0.933 0.00 37 0.910 P02533 M272T Disease 0.884 0.882 0.00 31 0.885 P02533 N123K Disease 0.985 0.829 0.00 37 0.894 P02533 N123S Disease 0.977 0.901 0.00 27 0.911 P02533 Q120R Disease 0.859 0.901 0.01 17 0.807 P02533 R125C Disease 0.990 0.939 0.00 37 0.915 P02533 R125G Disease 0.967 0.863 0.00 37 0.883 P02533 R125H Disease 0.927 0.898 0.00 27 0.877 P02533 R125S Disease 0.959 0.813 0.00 32 0.876 P02533 R134P Disease 0.956 0.939 0.00 52 0.939 P02533 R148C Disease 0.962 0.765 0.00 24 0.859 P02533 R211P Disease 0.865 0.956 0.00 64 0.931 P02533 R388C Disease 0.989 0.713 0.00 40 0.892 P02533 R388H Disease 0.926 0.640 0.00 20 0.813 P02533 R416P Disease 0.959 0.941 0.08 62 0.941 P02533 R417P Disease 0.824 0.929 0.14 49 0.910 P02533 V133A Polymorphism 0.996 0.747 0.00 41 0.916 P02533 V133L Disease 0.995 0.825 0.00 33 0.918 P02533 V270M Disease 0.914 0.900 0.00 19 0.871 P02533 Y129D Disease 0.991 0.834 0.00 56 0.938 P02533 Y415C Disease 0.999 0.761 0.00 53 0.938 P02533 Y415H Disease 0.999 0.489 0.00 56 0.887 P02538 N21S Polymorphism NA 0.110 0.78 -26 0.082 P02538 E472K Disease 0.895 0.856 0.00 44 0.850 P02538 F174V Disease 0.994 0.883 0.00 40 0.918 P02538 G111D Polymorphism 0.706 0.364 0.20 45 0.657 P02538 L469R Disease 0.980 0.909 0.00 55 0.939 P02545 A43T Disease 0.795 0.821 0.01 19 0.859 P02545 A57P Disease 0.571 0.594 0.19 20 0.762 P02545 K97E Disease 0.520 0.273 0.08 2 0.567 P02545 L35V Disease 0.754 0.562 0.01 39 0.808 P02545 L85R Disease 0.943 0.814 0.02 52 0.920 P02545 R25G Disease 0.906 0.695 0.01 44 0.853 P02545 R25P Disease 0.939 0.655 0.01 59 0.908 P02545 R28W Disease 0.979 0.890 0.00 60 0.949 P02545 R50S Disease 0.903 0.905 0.00 39 0.903 P02545 R60G Disease 0.363 0.376 0.43 4 0.410 P02545 R62G Disease 0.474 0.366 0.14 36 0.506 P02545 R89L Disease 0.918 0.879 0.01 40 0.898 P02545 A529V Disease 0.139 0.130 0.79 -23 0.087 P02545 D192G Disease 0.732 0.654 0.03 30 0.794 P02545 D230N Disease 0.867 0.750 0.05 29 0.814 P02545 D446V Disease 0.920 0.815 0.01 33 0.880 P02545 E145K Disease NA 0.725 0.06 23 0.553 P02545 E161K Disease NA 0.575 0.02 5 0.528 P02545 E203G Disease 0.727 0.828 0.01 46 0.869 P02545 E203K Disease 0.658 0.942 0.02 40 0.798 P02545 E317K Disease 0.362 0.711 0.47 46 0.616 P02545 G465D Disease 0.611 0.807 0.04 43 0.654 P02545 G608S Disease NA 0.086 0.62 18 0.032 P02545 K486N Disease 0.378 0.345 0.64 6 0.286 P02545 K542N Disease 0.291 0.127 0.35 13 0.257 P02545 L140R Disease NA 0.751 0.74 -17 0.480 P02545 L215P Disease 0.787 0.855 0.01 47 0.873 P02545 L248P Disease 0.942 0.868 0.00 50 0.927 P02545 L530P Disease 0.970 0.984 0.00 37 0.952 P02545 N195K Disease 0.894 0.219 0.00 14 0.551 P02545 N456I Disease 0.975 0.928 0.00 49 0.952 P02545 R133L Disease NA 0.933 0.03 16 0.625 P02545 R133P Disease NA 0.970 0.02 55 0.923 P02545 R190Q Disease 0.675 0.775 0.01 43 0.819 P02545 R190W Disease 0.960 0.905 0.00 43 0.926 P02545 R298C Disease 0.953 0.440 0.00 43 0.727 P02545 R349L Disease 0.950 0.747 0.00 33 0.836 P02545 R377H Disease 0.824 0.797 0.02 33 0.787 P02545 R377L Disease 0.821 0.931 0.02 42 0.875 P02545 R399C Disease 0.561 0.139 0.05 25 0.404 P02545 R435C Disease 0.734 0.613 0.04 27 0.765 P02545 R453W Disease 0.941 0.759 0.01 28 0.848 P02545 R471C Disease 0.958 0.945 0.01 53 0.960 P02545 R482L Disease 0.577 0.423 0.03 32 0.597 P02545 R482Q Disease 0.368 0.349 0.22 11 0.417 P02545 R482W Disease 0.890 0.714 0.00 38 0.866 P02545 R527C Disease 0.895 0.749 0.01 41 0.798 P02545 R527H Disease 0.682 0.277 0.05 17 0.490 P02545 R527P Disease 0.744 0.773 0.05 23 0.804 P02545 R541H Disease 0.701 0.509 0.51 36 0.687 P02545 R541S Disease 0.555 0.671 0.26 34 0.550 P02545 R582H Disease 0.299 0.240 0.00 46 0.314 P02545 R624H Disease NA 0.126 0.00 65 0.306 P02545 S143F Disease NA 0.653 0.03 13 0.705 P02545 S143P Disease NA 0.870 0.19 15 0.798 P02545 S573L Disease NA 0.098 0.02 -14 0.136 P02545 T528R Disease 0.658 0.802 0.01 57 0.894 P02545 Y267C Disease 0.948 0.836 0.00 55 0.923 P02545 Y481H Disease 0.785 0.750 0.00 69 0.843 P02549 G46V Disease 0.033 0.134 0.12 4 0.172 P02549 I24S Disease 0.276 0.664 0.00 12 0.589 P02549 K48R Disease 0.117 0.100 0.92 -26 0.092 P02549 L49F Disease 0.223 0.404 0.00 9 0.385 P02549 R28C Disease NA 0.339 0.09 31 0.318 P02549 R28H Disease NA 0.227 0.22 30 0.364 P02549 R28L Disease NA 0.228 1.00 14 0.274 P02549 R28S Disease NA 0.258 0.40 11 0.346 P02549 R34W Disease 0.657 0.677 0.00 36 0.786 P02549 R41W Disease 0.088 0.371 0.04 33 0.371 P02549 R45S Disease 0.218 0.560 0.06 29 0.446 P02549 R45T Disease 0.247 0.506 0.07 34 0.544 P02549 V31A Disease NA 0.423 0.01 -28 0.330 P02549 A970D Polymorphism 0.506 0.587 0.18 21 0.480 P02549 D791E Disease 0.219 0.193 1.00 -28 0.185 P02549 G151D Disease NA 0.196 0.12 23 0.342 P02549 H469P Disease 0.340 0.248 0.05 44 0.349 P02549 I809V Polymorphism 0.281 0.213 0.55 16 0.295 P02549 L207P Disease NA 0.215 0.01 49 0.453 P02549 L260P Disease NA 0.255 0.00 60 0.533 P02549 Q471P Disease 0.615 0.227 0.09 17 0.552 P02549 R701H Polymorphism 0.411 0.180 0.15 -17 0.196 P02549 S109F Polymorphism 0.042 0.159 0.05 8 0.172 P02549 S261P Disease NA 0.217 0.33 29 0.393 P02549 T853R Polymorphism 0.479 0.198 0.37 15 0.225 P02549 C1568R Polymorphism 0.326 0.203 0.96 32 0.171 P02549 I2265T Polymorphism NA 0.104 0.88 -13 0.079 P02549 K1693Q Polymorphism 0.172 0.186 0.51 6 0.166 P02549 N1836S Polymorphism 0.335 0.174 0.92 -2 0.119 P02549 R1330I Polymorphism 0.857 0.178 0.01 49 0.561 P02647 L84R Disease 0.883 0.933 0.01 56 0.948 P02647 P27R Polymorphism 0.958 0.448 0.08 31 0.716 P02647 T92I Polymorphism 0.474 0.514 0.35 17 0.470 P02647 D113E Polymorphism 0.248 0.167 0.55 -8 0.133 P02647 D126H Polymorphism 0.612 0.174 0.07 30 0.400 P02647 E163G Polymorphism 0.224 0.039 0.34 3 0.145 P02647 E171V Polymorphism 0.868 0.585 0.02 36 0.764 P02647 K131M Polymorphism 0.679 0.199 0.09 28 0.304 P02647 R184P Polymorphism 0.780 0.938 0.02 56 0.928 P02649 E21K Polymorphism 0.272 0.122 0.31 35 0.102 P02649 E31K Disease NA 0.077 0.11 -2 0.104 P02649 L46P Polymorphism 0.333 0.698 0.14 12 0.627 P02649 R43C Disease 0.791 0.194 0.04 30 0.406 P02649 T60A Polymorphism 0.259 0.219 0.03 20 0.284 P02649 A124V Polymorphism 0.384 0.082 0.10 16 0.143 P02649 A170P Polymorphism 0.682 0.471 0.03 46 0.699 P02649 C130R Disease 0.474 0.091 1.00 3 0.032 P02649 K164E Disease 0.745 0.178 0.17 6 0.281 P02649 K164Q Disease 0.734 0.129 0.11 26 0.245 P02649 P102R Polymorphism 0.912 0.611 0.00 34 0.898 P02649 R152Q Polymorphism 0.285 0.120 0.67 37 0.165 P02649 R154C Disease 0.850 0.383 0.00 41 0.631 P02649 R154S Disease 0.636 0.507 0.01 33 0.707 P02649 R160C Disease 0.901 0.099 0.03 36 0.305 P02649 R163C Disease 0.864 0.096 0.00 34 0.331 P02649 R163P Disease 0.382 0.500 0.06 40 0.619 P02649 R176C Disease 0.716 0.096 0.00 41 0.286 P02649 R246C Polymorphism 0.572 0.104 0.02 39 0.194 P02654 I16M Polymorphism 0.081 0.055 1.00 -72 0.023 P02654 T71S Polymorphism 0.160 0.124 0.13 12 0.104 P02655 E60K Polymorphism 0.086 0.060 1.00 -4 0.042 P02655 K41T Polymorphism 0.240 0.058 0.06 26 0.049 P02655 K77Q Polymorphism 0.451 0.320 0.00 48 0.563 P02655 W48R Disease 0.744 0.549 0.00 60 0.882 P02656 K78E Disease 0.255 0.213 0.43 39 0.199 P02671 R35H Polymorphism NA 0.409 0.00 24 0.588 P02671 S66T Polymorphism 0.631 0.397 0.44 0 0.584 P02671 E545V Disease NA 0.158 0.06 31 0.163 P02671 R573L Disease NA 0.105 0.73 29 0.077 P02671 T331A Polymorphism NA 0.093 0.59 3 0.036 P02671 T456A Polymorphism 0.117 0.226 0.00 22 0.321 P02675 K2E Polymorphism NA 0.168 NA 4 0.026 P02675 G430D Disease 0.690 0.909 0.03 66 0.641 P02675 L383R Disease 0.717 0.925 0.00 62 0.933 P02675 N170H Polymorphism 0.289 0.309 0.23 8 0.361 P02675 P100S Polymorphism 0.071 0.195 0.68 -42 0.221 P02675 P265L Polymorphism 0.716 0.752 0.43 37 0.803 P02675 R196C Disease 0.809 0.779 0.01 3 0.806 P02679 M410V Polymorphism 0.383 0.900 0.00 48 0.812 P02708 C463W Disease 0.895 0.808 0.00 50 0.913 P02708 D383V Polymorphism 0.213 0.109 0.35 14 0.246 P02708 F278V Disease 0.992 0.879 0.00 50 0.929 P02708 F301L Disease 0.978 0.664 0.00 20 0.835 P02708 G198S Disease 0.549 0.857 0.18 -10 0.486 P02708 N262K Disease 0.461 0.731 0.04 55 0.711 P02708 R254L Disease 0.997 0.891 0.00 65 0.899 P02708 S314I Disease 0.612 0.402 0.35 -25 0.457 P02708 T299I Disease 0.215 0.553 0.00 19 0.498 P02708 V177L Disease 0.281 0.602 0.02 40 0.600 P02708 V201M Disease 0.456 0.436 0.01 29 0.424 P02708 V294F Disease 0.552 0.791 0.00 35 0.827 P02708 V330I Disease 0.199 0.547 0.01 -13 0.440 P02724 G24D Polymorphism 0.158 0.255 0.63 11 0.250 P02730 E40K Polymorphism 0.070 0.219 0.81 -10 0.282 P02730 E90K Disease 0.125 0.858 0.14 13 0.188 P02730 L73M Polymorphism 0.234 0.094 0.29 -41 0.179 P02730 A285D Disease 0.575 0.695 0.01 29 0.824 P02730 A858D Disease 0.511 0.641 0.01 23 0.761 P02730 D705Y Disease 0.995 0.914 0.00 39 0.941 P02730 E508K Polymorphism 0.869 0.804 0.03 31 0.867 P02730 G130R Disease 0.243 0.643 0.08 13 0.632 P02730 G455E Disease 0.448 0.863 0.01 47 0.879 P02730 G455R Disease 0.527 0.833 0.01 47 0.878 P02730 G609R Disease 0.953 0.892 0.01 44 0.919 P02730 G701D Disease 0.987 0.888 0.00 32 0.945 P02730 G714R Disease 0.905 0.880 0.08 17 0.869 P02730 G771D Disease 0.987 0.912 0.00 44 0.940 P02730 H734R Disease 0.984 0.921 0.01 65 0.956 P02730 H834P Disease 0.633 0.959 0.01 67 0.941 P02730 I783N Disease 0.757 0.931 0.00 57 0.934 P02730 L687P Disease 0.950 0.880 0.01 49 0.926 P02730 L707P Disease 0.909 0.937 0.00 34 0.890 P02730 M663K Disease 0.816 0.747 0.03 14 0.780 P02730 P147S Disease 0.721 0.339 0.03 -20 0.603 P02730 P327R Disease 0.363 0.211 0.37 37 0.372 P02730 R490C Disease 0.993 0.917 0.00 54 0.949 P02730 R490H Disease 0.988 0.852 0.01 55 0.939 P02730 R518C Disease 0.904 0.945 0.00 61 0.941 P02730 R589C Disease 0.881 0.839 0.00 41 0.877 P02730 R589H Disease 0.709 0.716 0.04 30 0.818 P02730 R589S Disease 0.606 0.764 0.03 11 0.599 P02730 R602P Disease 0.990 0.973 0.00 74 0.950 P02730 R760Q Disease 0.985 0.914 0.06 43 0.916 P02730 R760W Disease 0.996 0.957 0.00 47 0.920 P02730 R808C Disease 0.904 0.918 0.00 53 0.926 P02730 R808H Disease 0.783 0.896 0.00 45 0.884 P02730 R832H Polymorphism 0.852 0.775 0.01 33 0.847 P02730 R870W Disease 0.929 0.927 0.00 59 0.944 P02730 S613F Disease 0.751 0.752 0.00 16 0.846 P02730 S690G Polymorphism 0.657 0.536 0.03 16 0.774 P02730 S731P Disease 0.580 0.917 0.00 51 0.897 P02730 S773P Disease 0.971 0.906 0.00 40 0.934 P02730 T837A Disease 0.278 0.914 0.02 52 0.886 P02730 T837M Disease 0.645 0.935 0.00 58 0.934 P02730 T837R Disease 0.447 0.967 0.01 66 0.941 P02730 V488M Disease 0.673 0.479 0.05 10 0.633 P02735 F86L Polymorphism 0.306 0.123 1.00 -2 0.099 P02735 H89R Polymorphism 0.186 0.099 1.00 9 0.107 P02735 E102K Polymorphism 0.233 0.383 0.28 -29 0.247 P02745 E23K Polymorphism 0.218 0.101 0.62 25 0.212 P02747 G34R Disease 0.710 0.949 0.02 79 0.936 P02748 C119G Disease 0.916 0.973 0.00 70 0.951 P02749 V5A Polymorphism 0.116 0.141 0.74 -50 0.102 P02749 C325G Polymorphism 0.429 0.721 0.00 53 0.846 P02749 R154H Polymorphism 0.117 0.469 0.11 5 0.164 P02749 S107N Polymorphism 0.202 0.397 0.33 8 0.227 P02750 G64S Polymorphism 0.089 0.169 0.82 -6 0.102 P02750 P133S Polymorphism 0.503 0.566 0.55 50 0.435 P02751 Q15L Polymorphism 0.160 0.101 1.00 -24 0.032 P02751 Y973C Disease NA 0.664 0.00 62 0.897 P02751 L1883R Disease 0.755 0.300 0.00 62 0.862 P02751 W1834R Disease 0.750 0.453 0.00 77 0.844 P02763 R167C Polymorphism 0.124 0.184 0.13 27 0.108 P02765 R317C Polymorphism 0.754 0.812 0.03 38 0.857 P02765 T248M Polymorphism 0.564 0.150 0.08 27 0.310 P02765 T256S Polymorphism 0.246 0.059 0.85 -16 0.070 P02765 V142L Polymorphism 0.345 0.230 0.12 -14 0.242 P02766 A56P Disease 0.663 0.611 0.29 -22 0.650 P02766 A65D Disease 0.214 0.472 0.21 28 0.384 P02766 A65S Disease 0.228 0.207 0.39 -11 0.181 P02766 A65T Disease 0.246 0.211 0.37 -3 0.192 P02766 C30R Disease 0.317 0.776 0.00 34 0.691 P02766 D38E Disease 0.254 0.764 0.01 36 0.678 P02766 D38G Disease 0.468 0.883 0.01 49 0.885 P02766 D58A Disease 0.187 0.335 0.11 27 0.340 P02766 D58V Disease 0.410 0.473 0.04 35 0.596 P02766 E62D Disease 0.333 0.128 0.35 -42 0.191 P02766 E62G Disease 0.220 0.139 0.17 -14 0.210 P02766 E74G Disease 0.427 0.190 0.02 34 0.337 P02766 E74K Disease 0.228 0.177 0.08 -2 0.228 P02766 E81G Disease 0.361 0.118 0.20 4 0.187 P02766 E81K Disease 0.280 0.102 0.21 -1 0.098 P02766 F53I Disease 0.339 0.540 0.03 8 0.604 P02766 F53L Disease 0.260 0.473 0.13 3 0.374 P02766 F53V Disease 0.179 0.604 0.04 10 0.586 P02766 F64S Disease 0.307 0.507 0.01 28 0.619 P02766 F84L Disease 0.254 0.788 0.73 -14 0.397 P02766 G26S Polymorphism 0.166 0.045 0.65 -40 0.061 P02766 G67A Disease 0.212 0.366 0.58 -5 0.313 P02766 G67E Disease 0.188 0.458 0.41 26 0.384 P02766 G67R Disease 0.232 0.528 0.18 46 0.658 P02766 G67V Disease 0.170 0.539 0.28 42 0.599 P02766 G73E Disease 0.561 0.574 0.00 77 0.814 P02766 I88L Disease 0.377 0.179 0.47 -32 0.078 P02766 I93V Disease 0.212 0.214 0.01 19 0.293 P02766 K55N Disease 0.192 0.510 0.21 3 0.462 P02766 K90N Disease 0.712 0.649 0.02 27 0.735 P02766 L32P Disease 0.543 0.930 0.00 47 0.864 P02766 L75P Disease 0.368 0.394 0.02 30 0.515 P02766 L75Q Disease 0.299 0.240 0.01 31 0.386 P02766 L78H Disease 0.716 0.534 0.01 61 0.906 P02766 L78R Disease 0.640 0.712 0.01 65 0.907 P02766 M33I Polymorphism 0.481 0.259 0.07 34 0.410 P02766 P44S Disease 0.390 0.852 0.00 48 0.794 P02766 R54T Disease 0.307 0.315 0.04 33 0.434 P02766 S43N Disease 0.252 0.310 0.49 -12 0.297 P02766 S70I Disease 0.539 0.236 0.01 27 0.523 P02766 S70R Disease 0.194 0.249 0.02 35 0.330 P02766 S72P Disease 0.557 0.291 0.07 5 0.495 P02766 S97Y Disease 0.611 0.334 0.03 4 0.536 P02766 T69A Disease 0.421 0.532 0.00 59 0.725 P02766 T69I Disease 0.418 0.719 0.00 57 0.852 P02766 T79K Disease 0.319 0.217 0.26 19 0.375 P02766 T80A Disease 0.487 0.380 0.45 -3 0.254 P02766 V40I Disease 0.450 0.294 0.24 7 0.409 P02766 V48M Disease 0.591 0.305 0.12 1 0.387 P02766 V50A Disease 0.256 0.384 0.00 29 0.426 P02766 V50G Disease 0.556 0.710 0.00 34 0.798 P02766 V50L Disease 0.233 0.204 0.07 -5 0.178 P02766 V50M Disease 0.467 0.300 0.00 24 0.446 P02766 V91A Disease 0.418 0.234 0.01 23 0.405 P02766 W61L Disease 0.220 0.794 0.11 53 0.848 P02766 Y89H Disease 0.697 0.715 0.00 66 0.917 P02766 Y98F Disease 0.620 0.644 0.09 46 0.584 P02766 A111S Disease 0.382 0.341 0.01 27 0.487 P02766 A117G Disease 0.610 0.516 0.01 10 0.697 P02766 A117S Disease 0.685 0.526 0.05 1 0.699 P02766 A140S Disease 0.303 0.423 0.00 44 0.626 P02766 E109K Disease 0.211 0.485 0.12 14 0.462 P02766 E109Q Disease 0.305 0.319 0.16 -40 0.236 P02766 I104N Disease 0.458 0.500 0.08 8 0.472 P02766 I104S Disease 0.305 0.505 0.11 4 0.414 P02766 I104T Disease 0.271 0.319 0.20 -17 0.232 P02766 I127M Disease 0.278 0.383 0.01 46 0.528 P02766 I127V Disease 0.271 0.193 1.00 -15 0.176 P02766 L131M Disease 0.543 0.327 0.05 50 0.438 P02766 N144S Disease 0.228 0.068 0.32 -23 0.062 P02766 P122R Polymorphism 0.286 0.174 0.54 1 0.142 P02766 R124C Polymorphism 0.697 0.256 0.00 39 0.535 P02766 R124H Polymorphism 0.353 0.043 1.00 -20 0.028 P02766 T126N Disease 0.482 0.519 0.34 33 0.713 P02766 V142A Disease 0.240 0.349 0.00 49 0.664 P02766 V142I Disease 0.413 0.277 0.00 37 0.456 P02766 Y134C Disease 0.815 0.793 0.00 65 0.925 P02766 Y134H Disease 0.383 0.539 0.00 66 0.800 P02766 Y136S Disease 0.690 0.837 0.00 60 0.918 P02768 F73Y Polymorphism 0.410 0.326 0.13 -13 0.265 P02768 L90P Disease 0.824 0.828 0.14 47 0.780 P02768 A215T Polymorphism 0.146 0.084 0.49 -29 0.119 P02768 K490E Polymorphism 0.418 0.326 0.89 15 0.279 P02768 R242H Disease 0.641 0.259 0.02 19 0.562 P02768 R242P Disease 0.735 0.810 0.02 44 0.795 P02771 A570G Polymorphism 0.420 0.116 0.36 4 0.235 P02771 K187Q Polymorphism 0.340 0.125 0.27 -3 0.244 P02774 D432E Polymorphism 0.152 0.232 0.36 -14 0.099 P02774 K436T Polymorphism 0.106 0.077 0.20 -17 0.064 P02774 R445H Polymorphism 0.091 0.082 0.15 32 0.126 P02786 G142S Polymorphism 0.194 0.090 0.82 -17 0.100 P02786 L212V Polymorphism 0.135 0.544 0.46 19 0.245 P02786 R677H Polymorphism 0.865 0.817 0.01 41 0.880 P02787 A76V Polymorphism 0.717 0.797 0.00 37 0.790 P02787 D77N Disease 0.873 0.843 0.00 54 0.933 P02787 S55R Polymorphism 0.110 0.396 0.70 -13 0.167 P02787 A477P Disease 0.806 0.961 0.00 61 0.900 P02787 D296G Polymorphism 0.144 0.254 0.40 -4 0.198 P02787 G142S Polymorphism 0.624 0.787 0.09 26 0.709 P02787 G671E Polymorphism 0.911 0.938 0.00 41 0.913 P02787 H319R Polymorphism 0.116 0.106 0.34 -29 0.118 P02787 W377C Polymorphism 0.966 0.581 0.00 51 0.916 P02788 E579D Polymorphism 0.169 0.408 0.49 -12 0.223 P02788 G422C Polymorphism 0.977 0.895 0.01 55 0.954 P02788 I148T Polymorphism 0.617 0.821 0.00 42 0.791 P02790 D52N Polymorphism 0.263 0.169 0.30 -10 0.251 P02792 A96T Disease 0.812 0.860 0.00 20 0.771 P02795 A42V Polymorphism 0.376 0.427 0.01 29 0.320 P02810 D66N Polymorphism 0.155 0.106 0.49 0 0.060 P02810 I42L Polymorphism 0.145 0.082 0.35 -18 0.035 P02810 R119C Polymorphism 0.432 0.226 0.05 45 0.115 P02812 S274P Polymorphism NA 0.162 0.37 -32 0.037 P02818 R94Q Polymorphism 0.325 0.309 0.26 -26 0.151 P03372 G77S Polymorphism NA 0.225 0.71 0 0.166 P03372 G160C Polymorphism NA 0.609 0.05 -9 0.432 P03886 A52T Disease 0.262 0.592 0.02 27 0.624 P03886 M31T Disease NA 0.903 0.05 31 0.728 P03886 M31V Disease NA 0.837 0.25 25 0.694 P03886 Y30H Disease NA 0.677 0.12 49 0.631 P03886 L285P Disease 0.717 0.860 0.00 60 0.905 P03886 L288P Polymorphism 0.833 0.857 0.00 53 0.923 P03886 S205P Polymorphism 0.548 0.904 0.00 56 0.739 P03886 Y277C Polymorphism 0.637 0.775 0.01 48 0.871 P03886 Y304H Disease 0.111 0.274 0.67 -36 0.133 P03891 I69V Polymorphism 0.514 0.121 0.01 -28 0.365 P03891 P42L Polymorphism 0.634 0.865 0.00 40 0.816 P03891 V43I Polymorphism 0.289 0.111 1.00 -26 0.093 P03891 A331S Disease 0.417 0.219 0.26 -29 0.187 P03891 A331T Polymorphism 0.369 0.185 0.40 -39 0.169 P03891 G259S Disease 0.541 0.909 0.00 54 0.712 P03891 I159T Polymorphism 0.681 0.341 0.09 -11 0.606 P03891 L237M Polymorphism 0.636 0.128 0.26 -22 0.208 P03891 N150D Disease 0.662 0.563 0.13 -3 0.576 P03891 N150S Polymorphism 0.516 0.564 0.06 -11 0.115 P03897 A47T Disease 0.309 0.797 0.00 49 0.623 P03897 M53V Polymorphism 0.236 0.467 0.19 32 0.363 P03901 I61T Polymorphism 0.467 0.596 0.00 -14 0.487 P03901 M36I Polymorphism 0.202 0.782 0.00 11 0.541 P03901 N57S Polymorphism 0.164 0.147 1.00 -20 0.095 P03901 V65A Disease 0.186 0.365 0.19 -28 0.254 P03905 A79P Polymorphism NA 0.902 0.00 61 0.923 P03905 I132T Polymorphism NA 0.687 0.00 42 0.789 P03905 R340H Disease 0.630 0.933 0.00 61 0.724 P03905 T109A Disease NA 0.312 0.46 -36 0.262 P03905 V313I Disease 0.333 0.039 0.57 -47 0.054 P03915 P17S Polymorphism NA 0.190 0.38 -14 0.192 P03915 S99P Polymorphism 0.870 0.882 0.00 54 0.820 P03915 A171V Disease 0.758 0.916 0.00 33 0.775 P03915 A458T Disease 0.627 0.783 0.38 -5 0.400 P03915 D393N Disease 0.823 0.891 0.00 52 0.893 P03915 D503G Polymorphism 0.295 0.801 0.09 43 0.555 P03915 E145G Disease 0.896 0.823 0.06 51 0.711 P03915 F124L Disease 0.637 0.661 0.00 33 0.819 P03915 G146D Polymorphism 0.677 0.879 0.00 42 0.773 P03915 G465E Disease 0.960 0.929 0.00 69 0.929 P03915 M314V Polymorphism 0.567 0.830 0.25 28 0.603 P03915 N165S Polymorphism 0.448 0.708 0.10 23 0.547 P03915 T211P Polymorphism 0.538 0.790 0.03 -5 0.685 P03915 T331A Polymorphism 0.518 0.464 0.01 28 0.671 P03923 A72V Disease 0.614 0.919 0.00 57 0.918 P03923 A74V Disease 0.608 0.925 0.00 11 0.575 P03923 G36S Disease 0.225 0.704 0.11 -25 0.352 P03923 I26M Disease 0.472 0.653 0.02 14 0.704 P03923 L60S Disease 0.815 0.813 0.00 50 0.907 P03923 M64I Disease 0.190 0.795 0.01 22 0.677 P03923 M64V Disease 0.233 0.865 0.01 23 0.710 P03923 V31A Polymorphism 0.201 0.669 0.46 -8 0.261 P03923 Y59C Disease 0.919 0.848 0.00 67 0.929 P03923 Y165C Polymorphism 0.377 0.778 0.00 10 0.761 P03950 C63W Disease 0.990 0.991 0.00 76 0.923 P03950 F12S Disease 0.643 0.578 0.00 33 0.596 P03950 K41E Disease 0.259 0.170 0.90 -27 0.106 P03950 K41I Disease 0.572 0.150 0.10 0 0.373 P03950 K64I Disease 0.968 0.925 0.00 52 0.969 P03950 K84E Polymorphism 0.262 0.652 0.94 -21 0.383 P03950 P20S Disease 0.581 0.109 0.64 -41 0.216 P03950 Q36L Disease 0.468 0.926 0.00 -2 0.729 P03950 R55K Disease 0.100 0.107 1.00 -75 0.099 P03950 S52N Disease 0.212 0.200 0.31 -35 0.217 P03950 H138R Disease 0.986 0.977 0.00 67 0.970 P03950 P136L Disease 0.991 0.962 0.00 37 0.954 P03950 V137I Disease 0.157 0.809 0.03 -5 0.407 P03951 C46F Disease NA 0.786 0.00 54 0.843 P03951 C56R Disease NA 0.842 0.00 62 0.894 P03951 D34H Disease NA 0.270 0.00 60 0.442 P03951 P66L Polymorphism NA 0.091 0.08 15 0.089 P03951 A430V Disease 0.527 0.851 0.00 56 0.851 P03951 C255Y Disease 0.498 0.842 0.00 62 0.892 P03951 E341K Disease 0.104 0.456 0.25 3 0.197 P03951 E565K Disease 0.105 0.681 0.06 18 0.127 P03951 F301L Disease 0.245 0.405 0.00 43 0.577 P03951 F460V Disease 0.320 0.292 0.32 -32 0.203 P03951 G263E Disease NA 0.531 0.00 47 0.596 P03951 G418V Disease 0.770 0.767 0.00 60 0.880 P03951 I308F Polymorphism 0.429 0.224 0.00 42 0.379 P03951 I618S Disease 0.519 0.858 0.00 44 0.863 P03951 K101R Disease NA 0.320 0.00 44 0.599 P03951 K270I Disease NA 0.133 0.31 13 0.228 P03951 L320P Disease 0.301 0.518 0.06 29 0.634 P03951 P538L Disease 0.078 0.590 0.01 47 0.600 P03951 Q244R Disease 0.070 0.146 0.00 41 0.123 P03951 R326C Disease 0.778 0.690 0.00 59 0.898 P03951 S266N Disease NA 0.188 0.00 45 0.313 P03951 S594R Disease 0.591 0.917 0.00 75 0.882 P03951 T322I Disease 0.402 0.477 0.00 35 0.656 P03951 T404N Disease 0.433 0.368 0.01 4 0.252 P03951 T493I Disease 0.467 0.134 0.00 42 0.350 P03951 W246C Disease 0.633 0.467 0.00 58 0.733 P03951 W587S Disease 0.437 0.779 0.02 59 0.829 P03951 Y151C Disease NA 0.527 0.00 61 0.790 P03951 Y511H Disease 0.135 0.271 0.50 0 0.217 P03952 A178T Polymorphism NA 0.084 0.64 22 0.048 P03952 C548Y Disease 0.999 0.933 0.00 71 0.934 P03952 G123R Disease NA 0.500 0.00 68 0.811 P03952 H202Q Polymorphism NA 0.075 0.34 18 0.080 P03952 H208P Polymorphism NA 0.136 0.00 43 0.184 P03952 N143S Disease NA 0.202 0.00 22 0.280 P03952 R560Q Polymorphism 0.099 0.280 0.59 22 0.204 P03952 S381A Polymorphism 0.044 0.119 0.45 -15 0.109 P03952 T358A Polymorphism 0.175 0.219 0.06 38 0.296 P03956 D252G Polymorphism 0.989 0.904 0.00 70 0.953 P03956 R405Q Polymorphism 0.121 0.685 1.00 0 0.127 P03956 S406T Polymorphism 0.379 0.381 0.78 -17 0.276 P03971 L70P Disease NA 0.577 0.00 15 0.664 P03971 V12G Disease NA 0.304 0.00 -43 0.207 P03971 C525Y Disease NA 0.900 0.00 65 0.904 P03971 G101V Disease NA 0.666 0.00 63 0.815 P03971 H506Q Disease NA 0.713 0.00 71 0.880 P03971 Q185E Polymorphism NA 0.351 0.00 59 0.695 P03971 Q325R Polymorphism NA 0.128 0.00 24 0.163 P03971 R123W Disease NA 0.172 0.01 -6 0.167 P03971 R194C Disease NA 0.205 0.05 26 0.347 P03971 V477A Disease NA 0.187 0.00 40 0.316 P03971 Y167C Disease NA 0.473 0.00 41 0.626 P03989 A65T Polymorphism 0.254 0.356 0.08 -19 0.365 P03989 A329T Polymorphism 0.280 0.163 0.69 -33 0.226 P03989 D101N Polymorphism 0.347 0.121 1.00 -29 0.127 P03989 D101S Polymorphism 0.216 0.075 0.52 -6 0.147 P03989 D140Y Polymorphism 0.371 0.399 1.00 5 0.303 P03989 N121S Polymorphism 0.326 0.342 0.72 -5 0.042 P03989 S155R Polymorphism 0.255 0.413 0.80 -12 0.208 P03989 T104N Polymorphism 0.311 0.453 0.33 -16 0.367 P03999 G79R Disease 0.504 0.915 0.00 45 0.880 P03999 P264S Disease 0.996 0.849 0.00 61 0.947 P03999 S214P Disease 0.505 0.341 0.15 19 0.573 P04000 A174V Polymorphism 0.069 0.500 0.82 -22 0.068 P04000 A298P Polymorphism 0.273 0.799 0.27 9 0.435 P04000 C203R Disease 0.997 0.892 0.00 76 0.940 P04000 I111V Polymorphism 0.117 0.093 0.79 -36 0.114 P04000 I230T Polymorphism 0.158 0.199 0.08 5 0.224 P04000 I274V Polymorphism 0.073 0.046 1.00 -10 0.040 P04000 L153M Polymorphism 0.136 0.381 0.32 -1 0.243 P04000 P307L Disease 0.734 0.871 0.00 37 0.850 P04000 S116Y Polymorphism 0.126 0.500 0.40 -21 0.072 P04000 S180A Polymorphism 0.121 0.166 1.00 -8 0.119 P04000 Y309F Polymorphism 0.158 0.530 1.00 -22 0.158 P04001 C203R Disease 0.997 0.890 0.00 82 0.850 P04003 A60V Polymorphism 0.088 0.801 0.47 -13 0.143 P04003 I300T Polymorphism NA 0.364 0.47 33 0.245 P04003 Y357H Polymorphism 0.193 0.421 0.54 8 0.113 P04004 A122S Polymorphism 0.069 0.078 0.49 -10 0.069 P04004 R268Q Polymorphism 0.402 0.269 0.26 26 0.384 P04004 T400M Polymorphism 0.146 0.065 0.03 24 0.102 P04035 I638V Polymorphism 0.214 0.617 0.40 -13 0.392 P04049 D486G Disease 0.876 0.943 0.00 63 0.927 P04049 D486N Disease 0.854 0.926 0.00 70 0.924 P04049 L613V Disease 0.384 0.258 0.13 28 0.379 P04049 P261A Disease NA 0.520 0.05 51 0.686 P04049 P261L Disease NA 0.582 0.00 46 0.661 P04049 P261S Disease NA 0.602 0.03 27 0.520 P04049 P308L Polymorphism NA 0.159 0.22 16 0.289 P04049 R256S Disease NA 0.660 0.23 43 0.562 P04049 S257L Disease NA 0.510 0.09 37 0.569 P04049 S259F Disease NA 0.684 0.05 35 0.730 P04049 S612T Disease 0.274 0.638 0.35 -65 0.331 P04049 T260R Disease NA 0.218 0.10 47 0.420 P04049 T491I Disease 0.746 0.557 0.10 34 0.754 P04049 T491R Disease 0.779 0.192 0.83 21 0.271 P04049 V263A Disease NA 0.434 0.12 45 0.350 P04054 D16A Polymorphism 0.053 0.164 0.71 -66 0.069 P04054 N89K Polymorphism 0.443 0.636 0.25 21 0.574 P04054 N89T Polymorphism 0.492 0.425 0.33 20 0.435 P04062 C55S Disease 0.621 0.852 0.00 44 0.852 P04062 D63N Disease 0.843 0.605 0.00 50 0.865 P04062 E80K Disease 0.232 0.149 0.20 36 0.252 P04062 F76V Disease 0.156 0.366 0.18 -23 0.190 P04062 G85E Disease 0.885 0.624 0.00 54 0.877 P04062 M92T Polymorphism 0.217 0.109 0.68 -32 0.100 P04062 R87Q Disease 0.899 0.749 0.06 57 0.883 P04062 R87W Disease 0.982 0.772 0.00 58 0.950 P04062 T82I Disease 0.770 0.328 0.02 31 0.607 P04062 V54L Disease 0.340 0.354 0.00 33 0.463 P04062 A129T Disease 0.316 0.484 0.10 -4 0.451 P04062 A175E Disease 0.300 0.454 0.47 31 0.430 P04062 A215D Disease 0.880 0.756 0.02 42 0.868 P04062 A229E Disease 0.216 0.276 0.44 -8 0.179 P04062 A229T Disease 0.382 0.147 0.39 -42 0.173 P04062 A348V Disease 0.781 0.671 0.02 10 0.774 P04062 A357D Disease 0.224 0.434 0.02 14 0.329 P04062 A380T Disease 0.354 0.194 0.22 43 0.336 P04062 A485P Disease 0.551 0.346 0.14 -32 0.555 P04062 A495P Disease 0.343 0.292 0.22 -5 0.396 P04062 C381G Disease 0.639 0.798 0.19 30 0.727 P04062 D166V Disease 0.964 0.901 0.00 51 0.940 P04062 D179H Disease 0.280 0.432 0.13 20 0.388 P04062 D354H Disease 0.802 0.605 0.05 45 0.833 P04062 D419A Disease 0.347 0.796 1.00 31 0.636 P04062 D419H Disease 0.729 0.848 0.11 45 0.877 P04062 D419N Disease 0.543 0.738 0.29 23 0.556 P04062 D438N Disease 0.594 0.476 0.97 -15 0.539 P04062 D438Y Disease 0.884 0.871 0.35 21 0.842 P04062 D448H Disease 0.295 0.371 0.17 -18 0.394 P04062 D448V Disease 0.379 0.333 0.05 -3 0.460 P04062 D513Y Disease 0.933 0.802 0.00 -6 0.837 P04062 E365K Disease 0.276 0.151 0.31 -3 0.185 P04062 E388K Disease 0.122 0.190 0.41 0 0.177 P04062 F252I Disease 0.395 0.723 0.06 -27 0.510 P04062 F255Y Disease 0.265 0.468 0.48 -43 0.299 P04062 F290L Disease 0.399 0.460 0.12 -35 0.424 P04062 F298L Disease 0.375 0.845 0.62 -9 0.472 P04062 F436S Disease 0.470 0.622 0.30 -8 0.453 P04062 F450I Disease 0.245 0.331 0.29 -8 0.282 P04062 F456V Disease 0.876 0.572 0.02 -32 0.653 P04062 G152E Disease 0.956 0.909 0.00 55 0.944 P04062 G228V Disease 0.595 0.557 0.39 -17 0.664 P04062 G232E Disease 0.896 0.824 0.00 71 0.921 P04062 G234E Disease 0.851 0.860 0.05 32 0.854 P04062 G234W Disease 0.978 0.902 0.01 34 0.930 P04062 G241E Disease 0.158 0.392 0.29 8 0.202 P04062 G241R Disease 0.181 0.500 0.14 11 0.266 P04062 G304D Disease 0.952 0.901 0.02 -10 0.903 P04062 G364R Disease 0.207 0.291 0.09 6 0.253 P04062 G416S Disease 0.912 0.710 0.18 43 0.884 P04062 G428E Disease 0.522 0.855 0.12 23 0.838 P04062 G429R Disease 0.960 0.898 0.00 49 0.926 P04062 G460D Disease 0.850 0.825 0.02 59 0.920 P04062 G517S Disease 0.493 0.291 0.00 -47 0.300 P04062 H201P Disease 0.571 0.577 0.08 0 0.674 P04062 H294Q Disease 0.156 0.119 0.15 -37 0.124 P04062 H490R Disease 0.307 0.207 0.85 27 0.107 P04062 I158S Disease 0.585 0.318 0.02 18 0.593 P04062 I158T Disease 0.530 0.208 0.04 19 0.418 P04062 I200N Disease 0.943 0.542 0.02 -38 0.628 P04062 I200S Disease 0.895 0.521 0.04 -41 0.625 P04062 I441F Disease 0.760 0.584 0.03 -43 0.588 P04062 I441T Disease 0.685 0.514 0.25 -41 0.575 P04062 K118N Disease 0.362 0.147 0.10 19 0.306 P04062 K196Q Disease 0.613 0.376 0.40 -17 0.568 P04062 K237E Disease 0.475 0.641 0.09 -28 0.500 P04062 K342I Disease 0.652 0.500 0.13 -14 0.657 P04062 K452Q Disease 0.652 0.500 0.16 22 0.680 P04062 K464E Disease 0.548 0.803 0.00 30 0.825 P04062 L213F Disease 0.484 0.370 0.04 0 0.323 P04062 L224F Disease 0.638 0.583 0.05 13 0.741 P04062 L303I Disease 0.331 0.879 0.70 -16 0.483 P04062 L363P Disease 0.949 0.905 0.00 38 0.901 P04062 L410V Disease 0.586 0.493 0.15 7 0.544 P04062 L483P Disease 0.607 0.894 0.01 -50 0.799 P04062 L483R Disease 0.814 0.837 0.01 16 0.858 P04062 L500P Disease 0.708 0.828 0.04 -38 0.722 P04062 M162V Disease 0.261 0.517 0.58 34 0.418 P04062 M400I Disease 0.267 0.299 0.44 27 0.315 P04062 M455V Disease 0.379 0.240 0.40 38 0.401 P04062 N156D Disease 0.439 0.611 0.56 35 0.489 P04062 N227K Disease 0.348 0.852 0.04 -22 0.552 P04062 N227S Disease 0.344 0.576 0.12 -27 0.452 P04062 N409S Disease 0.424 0.416 0.23 6 0.367 P04062 N421K Disease 0.767 0.974 0.37 10 0.832 P04062 N431I Disease 0.735 0.811 0.01 -31 0.793 P04062 N435T Disease 0.649 0.864 0.15 46 0.756 P04062 N501K Disease 0.778 0.956 0.00 44 0.877 P04062 P161L Disease 0.816 0.432 0.04 35 0.669 P04062 P161S Disease 0.217 0.386 0.20 41 0.341 P04062 P198L Disease 0.770 0.602 1.00 -27 0.633 P04062 P198T Disease 0.659 0.663 0.28 -4 0.782 P04062 P217S Disease 0.664 0.650 0.00 4 0.768 P04062 P221L Disease 0.964 0.831 0.00 51 0.938 P04062 P221T Disease 0.952 0.833 0.00 30 0.905 P04062 P305R Disease 0.963 0.901 0.00 -14 0.893 P04062 P328L Disease 0.887 0.413 0.00 2 0.626 P04062 P426L Disease 0.177 0.151 0.05 -12 0.187 P04062 P430L Disease 0.957 0.834 0.00 -18 0.890 P04062 P440L Disease 0.299 0.410 1.00 15 0.335 P04062 P454R Disease 0.870 0.685 0.14 35 0.807 P04062 R159Q Disease 0.820 0.961 0.05 65 0.947 P04062 R159W Disease 0.755 0.970 0.00 65 0.915 P04062 R170C Disease 0.822 0.308 0.02 42 0.632 P04062 R170L Disease 0.505 0.351 0.05 34 0.592 P04062 R209C Disease 0.778 0.425 0.05 12 0.642 P04062 R209P Disease 0.150 0.335 0.25 -1 0.175 P04062 R296Q Disease 0.690 0.474 0.39 -44 0.507 P04062 R324C Disease 0.921 0.722 0.01 39 0.856 P04062 R324H Disease 0.790 0.528 0.07 41 0.789 P04062 R368H Polymorphism 0.414 0.121 0.20 -24 0.240 P04062 R392G Disease 0.414 0.224 0.01 12 0.317 P04062 R392W Disease 0.817 0.174 0.00 -21 0.439 P04062 R398Q Disease 0.619 0.511 0.43 -37 0.445 P04062 R502C Disease 0.810 0.323 0.01 34 0.628 P04062 R502P Disease 0.571 0.446 0.04 7 0.551 P04062 R535C Disease 0.711 0.127 0.00 15 0.352 P04062 R535H Disease 0.389 0.145 0.00 30 0.168 P04062 S146L Disease 0.558 0.327 0.03 -3 0.571 P04062 S235P Disease 0.288 0.712 0.10 8 0.478 P04062 S276P Disease 0.673 0.586 0.11 28 0.760 P04062 S310N Disease 0.384 0.295 0.03 14 0.377 P04062 S403T Disease 0.165 0.318 0.50 -52 0.211 P04062 S405G Disease 0.371 0.416 0.82 -20 0.235 P04062 S405N Disease 0.287 0.206 1.00 -12 0.204 P04062 T173I Disease 0.812 0.433 0.01 29 0.669 P04062 T173P Disease 0.760 0.809 0.02 32 0.850 P04062 T270R Disease 0.848 0.764 0.01 37 0.863 P04062 T362I Disease NA 0.097 0.41 -25 0.184 P04062 T408M Disease 0.550 0.140 0.10 1 0.361 P04062 T530I Disease 0.885 0.905 0.00 -3 0.900 P04062 V230E Disease 0.548 0.298 0.17 37 0.521 P04062 V230G Disease 0.347 0.451 0.14 -42 0.398 P04062 V391L Disease 0.559 0.172 0.39 -24 0.209 P04062 V414L Disease 0.325 0.520 0.32 -23 0.441 P04062 V433L Disease 0.460 0.425 0.46 20 0.376 P04062 V437L Disease 0.385 0.349 0.29 -54 0.310 P04062 W223R Disease 0.640 0.906 0.20 5 0.777 P04062 W351C Disease 0.400 0.531 0.34 9 0.411 P04062 W417G Disease 0.861 0.873 0.31 44 0.858 P04062 W432R Disease 0.307 0.586 0.01 18 0.536 P04062 Y244C Disease 0.947 0.880 0.00 16 0.896 P04062 Y251H Disease 0.911 0.920 0.25 20 0.889 P04062 Y343C Disease 0.963 0.808 0.05 32 0.894 P04062 Y352H Disease 0.900 0.933 0.00 42 0.897 P04062 Y402C Disease 0.852 0.788 0.02 48 0.871 P04062 Y451H Disease 0.804 0.525 0.23 -31 0.625 P04062 Y457C Disease 0.965 0.863 0.00 28 0.911 P04066 R2W Polymorphism NA 0.122 NA -12 0.034 P04066 G65D Disease 0.539 0.952 0.00 74 0.929 P04066 P10R Polymorphism 0.137 0.214 NA -21 0.198 P04066 S68L Disease 0.763 0.945 0.01 51 0.923 P04066 C269S Polymorphism 0.184 0.801 0.80 13 0.397 P04066 L410R Disease NA 0.739 0.00 39 0.803 P04066 P146L Polymorphism 0.731 0.711 0.07 22 0.842 P04070 A43T Polymorphism 0.382 0.804 0.01 46 0.799 P04070 E62A Disease 0.978 0.868 0.00 40 0.934 P04070 R32C Disease NA 0.438 0.04 16 0.507 P04070 R42S Disease 0.508 0.983 0.00 57 0.912 P04070 R57W Disease 0.995 0.955 0.00 53 0.943 P04070 V76M Disease 0.407 0.113 0.11 20 0.268 P04070 A178P Disease 0.268 0.573 0.36 10 0.406 P04070 C426Y Disease 0.994 0.918 0.00 62 0.942 P04070 D401N Disease 0.547 0.916 0.02 64 0.850 P04070 G114R Disease 0.708 0.346 0.20 48 0.539 P04070 G145R Disease 0.985 0.925 0.13 53 0.949 P04070 G324R Disease 0.661 0.655 0.33 7 0.720 P04070 G334S Disease 0.631 0.850 0.40 26 0.547 P04070 G392R Disease 0.804 0.735 0.16 0 0.521 P04070 G418D Disease 0.994 0.824 0.00 71 0.942 P04070 G423S Disease 0.979 0.796 0.00 66 0.911 P04070 I243T Disease 0.477 0.585 0.01 54 0.771 P04070 P210L Disease 0.658 0.365 0.21 20 0.602 P04070 P289L Disease 0.772 0.500 0.24 48 0.823 P04070 P321L Disease 0.772 0.876 0.01 52 0.878 P04070 P369L Disease 0.467 0.182 0.30 14 0.290 P04070 R211W Disease 0.866 0.891 0.00 56 0.828 P04070 R220Q Disease 0.059 0.208 0.60 8 0.126 P04070 R220W Disease 0.103 0.738 0.05 19 0.171 P04070 R272C Disease 0.868 0.149 0.00 45 0.493 P04070 R328C Disease NA 0.595 0.05 34 0.792 P04070 R328H Disease NA 0.160 0.12 -15 0.218 P04070 T340M Disease 0.770 0.669 0.01 53 0.860 P04070 T436N Disease 0.600 0.599 0.01 54 0.851 P04070 V367A Disease 0.407 0.163 0.40 19 0.280 P04070 W444C Disease 0.996 0.864 0.00 69 0.934 P04070 Y441H Disease 0.626 0.320 0.00 61 0.926 P04075 E82Q Polymorphism 0.873 0.949 0.22 46 0.907 P04075 C339Y Disease 0.363 0.735 0.02 9 0.683 P04075 D129G Disease 0.866 0.930 0.00 29 0.877 P04075 E207K Disease 0.619 0.939 0.00 0 0.661 P04075 G142V Polymorphism 0.947 0.922 0.00 48 0.934 P04075 G347S Disease 0.263 0.809 0.14 -27 0.472 P04080 G4R Disease 0.952 0.902 0.00 70 0.943 P04090 M28K Polymorphism 0.119 0.202 0.67 10 0.083 P04090 P68Q Polymorphism 0.106 0.193 0.41 -22 0.082 P04090 V12F Polymorphism 0.130 0.450 0.25 -58 0.233 P04114 T98I Polymorphism NA 0.239 0.01 -4 0.351 P04114 I408T Polymorphism NA 0.079 0.15 19 0.123 P04114 P145S Polymorphism NA 0.513 0.13 38 0.507 P04114 P877L Polymorphism NA 0.341 0.01 49 0.361 P04114 R490W Disease NA 0.658 0.00 45 0.747 P04114 V730I Polymorphism NA 0.092 0.12 27 0.157 P04114 Y103H Polymorphism NA 0.110 0.10 55 0.269 P04114 A3121T Polymorphism 0.433 0.812 NA 42 0.790 P04114 A4481T Polymorphism 0.126 0.185 0.01 13 0.202 P04114 D2299H Polymorphism NA 0.301 NA 22 0.167 P04114 E2566K Polymorphism NA 0.322 NA 3 0.170 P04114 F1437L Polymorphism NA 0.088 NA 11 0.098 P04114 H1923R Polymorphism NA 0.328 NA 53 0.610 P04114 H3182N Polymorphism 0.176 0.418 NA -10 0.198 P04114 N1914S Polymorphism NA 0.140 NA 14 0.162 P04114 N2785H Polymorphism NA 0.108 0.00 38 0.130 P04114 R1128H Polymorphism NA 0.130 NA 6 0.121 P04114 R1388H Polymorphism NA 0.088 NA 6 0.094 P04114 R3527Q Disease 0.633 0.599 NA 55 0.824 P04114 R3558C Disease 0.719 0.448 NA 60 0.753 P04114 S3279G Polymorphism 0.472 0.649 NA 27 0.626 P04114 S3294P Polymorphism 0.690 0.960 NA 43 0.847 P04114 V4128M Polymorphism 0.410 0.048 NA 18 0.035 P04114 V4394A Polymorphism 0.490 0.194 0.01 28 0.369 P04118 L8P Polymorphism 0.843 0.771 0.01 -12 0.833 P04141 I117T Polymorphism 0.083 0.130 0.61 5 0.024 P04141 T115I Polymorphism 0.191 0.316 0.16 36 0.125 P04150 F29L Polymorphism NA 0.173 0.23 19 0.042 P04150 F65V Polymorphism NA 0.202 0.08 22 0.100 P04150 D233N Polymorphism NA 0.306 0.17 16 0.414 P04150 D641V Disease 0.525 0.404 0.01 47 0.612 P04150 G679S Disease 0.850 0.820 0.11 36 0.825 P04150 I559N Disease 0.681 0.636 0.00 43 0.734 P04150 I747M Disease 0.231 0.567 0.00 46 0.677 P04150 L112F Polymorphism NA 0.123 0.06 9 0.037 P04150 N363S Polymorphism NA 0.056 0.94 -2 0.059 P04150 R477H Disease 0.782 0.906 0.00 71 0.932 P04150 V729I Disease 0.158 0.293 0.02 28 0.333 P04155 T22I Polymorphism 0.296 0.092 0.12 -14 0.092 P04156 D178N Disease 0.474 0.774 0.00 44 0.792 P04156 D202N Disease 0.187 0.485 0.00 19 0.422 P04156 E196K Disease 0.144 0.198 0.01 6 0.220 P04156 E200K Disease 0.304 0.288 0.00 30 0.359 P04156 E211Q Disease 0.216 0.343 0.01 28 0.270 P04156 F198S Disease 0.288 0.648 0.01 26 0.667 P04156 G131V Disease 0.730 0.894 0.00 28 0.856 P04156 H187R Disease 0.168 0.361 0.00 43 0.488 P04156 M129V Polymorphism 0.137 0.447 0.01 5 0.254 P04156 M232R Disease 0.111 0.382 0.01 25 0.398 P04156 N171S Polymorphism 0.089 0.275 0.14 -9 0.179 P04156 P102L Disease 0.420 0.336 0.00 27 0.530 P04156 P105L Disease 0.475 0.278 0.00 41 0.427 P04156 P238S Polymorphism 0.147 0.392 0.00 -5 0.194 P04156 Q212P Disease 0.404 0.540 0.00 48 0.523 P04156 Q217R Disease 0.242 0.615 0.00 31 0.670 P04156 R208H Disease 0.400 0.500 0.00 26 0.698 P04156 V180I Disease 0.176 0.212 0.02 32 0.304 P04156 V203I Disease 0.084 0.045 0.80 -5 0.065 P04156 V210I Disease 0.077 0.079 0.19 11 0.082 P04179 E66V Polymorphism 0.222 0.480 0.40 -18 0.285 P04179 G76R Polymorphism 0.412 0.867 0.07 33 0.707 P04179 I82T Polymorphism 0.535 0.318 0.01 6 0.579 P04179 S10I Polymorphism 0.243 0.342 0.29 25 0.326 P04180 G54S Disease NA 0.909 0.00 63 0.917 P04180 G57R Disease NA 0.843 0.01 76 0.875 P04180 N29I Disease NA 0.287 0.00 28 0.242 P04180 P34L Disease NA 0.192 0.00 18 0.226 P04180 P34Q Disease NA 0.201 0.00 30 0.338 P04180 T37M Disease NA 0.134 0.00 17 0.177 P04180 V70E Disease NA 0.534 0.28 45 0.566 P04180 A117T Disease NA 0.500 0.06 -22 0.457 P04180 A165T Polymorphism 0.404 0.730 0.02 0 0.578 P04180 F406V Disease 0.453 0.357 0.19 -1 0.388 P04180 K242N Disease 0.747 0.655 0.00 41 0.797 P04180 L233P Disease 0.953 0.942 0.02 43 0.906 P04180 M276K Disease 0.541 0.690 0.01 62 0.764 P04180 M317I Disease 0.535 0.638 0.04 14 0.501 P04180 N252K Disease 0.726 0.860 0.32 34 0.810 P04180 P331S Disease 0.873 0.819 0.00 26 0.881 P04180 R123C Disease NA 0.907 0.00 55 0.897 P04180 R159Q Disease 0.739 0.629 0.26 20 0.705 P04180 R159W Disease 0.952 0.795 0.02 47 0.900 P04180 R164C Disease 0.935 0.868 0.01 48 0.912 P04180 R164H Disease 0.849 0.741 0.04 21 0.747 P04180 R171W Disease 0.986 0.956 0.00 56 0.949 P04180 R268H Disease 0.868 0.839 0.01 38 0.872 P04180 S115P Polymorphism NA 0.894 0.13 12 0.785 P04180 S205N Disease 0.777 0.918 0.03 68 0.933 P04180 S232T Polymorphism 0.397 0.651 0.20 5 0.442 P04180 T147I Disease NA 0.462 0.03 0 0.339 P04180 T298A Disease 0.717 0.655 0.17 45 0.774 P04180 T298I Disease 0.892 0.719 0.11 43 0.874 P04180 T345M Disease 0.922 0.941 0.00 59 0.941 P04180 T371M Disease 0.945 0.857 0.00 49 0.911 P04180 V333M Disease 0.821 0.889 0.34 31 0.874 P04180 Y180N Disease 0.856 0.764 0.00 24 0.823 P04181 C93F Disease 0.805 0.880 0.02 51 0.913 P04181 N54K Disease 0.700 0.647 0.01 59 0.848 P04181 N89K Disease 0.503 0.437 0.00 63 0.852 P04181 Q90E Disease 0.463 0.700 0.02 54 0.859 P04181 Y55H Disease 0.765 0.684 0.00 77 0.909 P04181 A226V Disease 0.677 0.881 0.00 45 0.682 P04181 A270P Disease 0.680 0.943 0.01 46 0.887 P04181 C394R Disease 0.512 0.754 0.00 45 0.749 P04181 G353D Disease 0.900 0.925 0.00 60 0.928 P04181 G375A Disease 0.991 0.878 0.00 61 0.938 P04181 H319Y Disease 0.962 0.938 0.00 69 0.916 P04181 L402P Disease 0.875 0.913 0.00 32 0.873 P04181 P241L Disease 0.919 0.823 0.05 51 0.856 P04181 P417L Disease 0.918 0.854 0.00 57 0.921 P04181 R154L Disease 0.734 0.926 0.00 47 0.876 P04181 R180T Disease 0.706 0.890 0.00 73 0.864 P04181 R250P Disease 0.571 0.948 0.03 59 0.861 P04181 R271K Disease 0.993 0.917 0.00 72 0.927 P04181 T267I Disease 0.788 0.787 0.01 48 0.847 P04181 V332M Disease 0.667 0.762 0.01 27 0.839 P04181 Y245C Disease 0.937 0.806 0.00 51 0.844 P04196 S79L Polymorphism 0.116 0.307 0.15 16 0.275 P04196 D118G Polymorphism 0.588 0.330 0.36 31 0.498 P04196 H340R Polymorphism 0.192 0.072 0.12 37 0.082 P04196 I180T Polymorphism 0.164 0.424 0.08 40 0.431 P04196 P204S Polymorphism 0.259 0.142 0.70 -25 0.084 P04196 R448C Polymorphism 0.118 0.108 0.00 40 0.068 P04198 R393H Disease 0.971 0.864 0.00 59 0.967 P04198 R393S Disease 0.960 0.923 0.00 57 0.951 P04198 R394H Disease 0.972 0.887 0.00 54 0.965 P04217 H395R Polymorphism 0.254 0.193 0.36 2 0.141 P04222 A73E Polymorphism 0.554 0.588 0.07 17 0.615 P04222 V76M Polymorphism 0.313 0.162 0.50 -38 0.168 P04222 D138V Polymorphism 0.512 0.231 0.68 18 0.545 P04222 G115R Polymorphism 0.837 0.848 0.00 68 0.890 P04222 I118T Polymorphism 0.491 0.084 1.00 -22 0.084 P04222 I119L Polymorphism 0.335 0.345 1.00 -28 0.332 P04222 N104K Polymorphism 0.238 0.760 0.18 7 0.509 P04222 S101N Polymorphism 0.295 0.060 1.00 -30 0.047 P04222 Y140S Polymorphism 0.439 0.767 0.17 46 0.713 P04229 K5R Polymorphism 0.057 0.219 0.87 -80 0.107 P04229 G74R Polymorphism 0.901 0.874 0.66 45 0.882 P04229 L96I Polymorphism 0.193 0.129 0.61 -42 0.113 P04229 Q39E Polymorphism 0.566 0.730 0.02 66 0.882 P04229 Q99E Polymorphism 0.285 0.470 0.41 -3 0.333 P04229 Q99H Polymorphism 0.666 0.408 0.09 27 0.648 P04229 R33K Polymorphism 0.226 0.418 0.30 20 0.376 P04229 T13A Polymorphism 0.318 0.129 1.00 -76 0.076 P04229 Y76F Polymorphism 0.204 0.167 0.73 0 0.161 P04229 A103E Polymorphism 0.209 0.233 0.32 0 0.238 P04229 G115V Polymorphism 0.232 0.451 0.53 5 0.331 P04229 R100A Polymorphism 0.247 0.249 1.00 11 0.334 P04229 R100E Polymorphism 0.210 0.474 0.95 16 0.329 P04229 T210I Polymorphism 0.579 0.355 0.05 30 0.652 P04229 V114A Polymorphism 0.408 0.493 0.94 18 0.449 P04229 Y107H Polymorphism 0.729 0.646 0.52 66 0.892 P04234 Q147R Polymorphism 0.746 0.515 0.53 35 0.748 P04259 N21S Polymorphism NA 0.113 0.68 -23 0.088 P04259 E472K Disease 0.895 0.858 0.00 43 0.849 P04259 I365V Polymorphism 0.345 0.033 1.00 -67 0.042 P04259 N227S Polymorphism 0.346 0.060 0.86 -60 0.070 P04264 K74I Disease NA 0.603 0.01 9 0.659 P04264 A454S Polymorphism 0.732 0.242 0.08 -18 0.597 P04264 D340V Disease 0.923 0.877 0.00 37 0.870 P04264 E490Q Disease 0.972 0.429 0.00 39 0.780 P04264 I330T Polymorphism 0.840 0.557 0.02 35 0.792 P04264 I479F Disease 0.992 0.881 0.00 42 0.915 P04264 I479T Disease 0.992 0.897 0.00 37 0.918 P04264 K633R Polymorphism 0.066 0.098 1.00 12 0.042 P04264 L161P Disease 0.910 0.973 0.00 57 0.941 P04264 L214P Disease 0.978 0.758 0.00 40 0.889 P04264 L486P Disease 0.983 0.905 0.00 57 0.940 P04264 N188K Disease 0.927 0.857 0.00 41 0.888 P04264 N188S Disease 0.905 0.891 0.00 34 0.899 P04264 N188T Disease 0.936 0.902 0.00 43 0.903 P04264 S186P Disease 0.678 0.871 0.02 14 0.856 P04264 S193P Disease 0.927 0.950 0.00 41 0.886 P04264 V155D Disease 0.981 0.945 0.02 63 0.949 P04264 V155G Disease 0.969 0.924 0.00 50 0.943 P04264 Y358N Polymorphism 0.922 0.849 0.00 35 0.874 P04264 Y482C Disease 0.999 0.801 0.00 51 0.935 P04275 C788Y Disease 0.725 0.943 0.03 51 0.901 P04275 F885S Polymorphism 0.974 0.752 0.00 29 0.916 P04275 G550R Disease 0.666 0.900 0.09 22 0.854 P04275 H484R Polymorphism 0.437 0.176 1.00 23 0.161 P04275 N528S Disease 0.952 0.744 0.03 27 0.862 P04275 R273W Disease 0.801 0.784 0.00 56 0.916 P04275 T789A Polymorphism 0.084 0.102 0.79 7 0.080 P04275 W377C Disease 0.991 0.788 0.01 64 0.971 P04275 A1461V Disease 0.207 0.315 0.00 13 0.323 P04275 C1060R Disease 0.986 0.900 0.00 62 0.985 P04275 C1272R Disease 0.589 0.941 0.17 77 0.903 P04275 C2362F Disease NA 0.952 0.04 55 0.856 P04275 C2739Y Disease NA 0.977 0.00 63 0.935 P04275 C2773R Disease NA 0.974 0.00 63 0.937 P04275 E1638K Disease NA 0.636 0.00 31 0.783 P04275 F1514C Disease NA 0.913 0.00 -5 0.838 P04275 G1324S Disease 0.388 0.624 0.00 19 0.528 P04275 G1609R Disease NA 0.650 0.00 34 0.789 P04275 G2705R Polymorphism NA 0.524 0.02 46 0.661 P04275 H1268D Disease 0.384 0.727 0.02 24 0.603 P04275 I1628T Disease NA 0.518 0.00 25 0.766 P04275 L1460V Disease 0.155 0.210 0.00 40 0.267 P04275 L1540P Disease NA 0.728 0.00 33 0.801 P04275 N2546Y Disease NA 0.339 0.01 59 0.592 P04275 P1266L Disease 0.527 0.906 0.00 -17 0.600 P04275 P1648S Disease NA 0.351 0.00 43 0.502 P04275 P2063S Disease NA 0.219 0.92 39 0.381 P04275 R1306W Disease 0.612 0.821 0.01 -21 0.829 P04275 R1308C Disease 0.474 0.654 0.02 7 0.683 P04275 R1341Q Disease 0.355 0.570 0.00 24 0.524 P04275 R1374C Disease 0.744 0.975 0.00 43 0.876 P04275 R1374H Disease 0.526 0.947 0.00 25 0.862 P04275 R1597G Disease NA 0.866 0.00 37 0.795 P04275 R1597Q Disease NA 0.846 0.00 42 0.858 P04275 R1597W Disease NA 0.884 0.00 45 0.879 P04275 S1613P Disease NA 0.607 0.00 12 0.522 P04275 V1314L Disease 0.093 0.323 0.08 -2 0.365 P04275 V1316M Disease 0.419 0.628 0.00 17 0.716 P04275 V1318L Disease 0.186 0.433 0.00 -45 0.265 P04275 V1565L Polymorphism NA 0.305 0.00 -22 0.338 P04275 V1607D Disease NA 0.706 0.00 51 0.846 P04275 V1665E Disease NA 0.431 0.00 39 0.566 P04275 W1313C Disease 0.245 0.615 0.10 7 0.376 P04275 Y1584C Polymorphism NA 0.923 0.00 -9 0.828 P04278 P185L Polymorphism NA 0.834 0.00 45 0.823 P04279 H108R Polymorphism 0.175 0.146 0.01 23 0.147 P04279 R372L Polymorphism NA 0.160 0.03 15 0.183 P04350 A365V Polymorphism 0.189 0.527 1.00 -7 0.321 P04350 I155M Polymorphism 0.349 0.500 0.06 -51 0.496 P04406 A22G Polymorphism 0.502 0.863 0.16 10 0.510 P04406 K251N Polymorphism 0.696 0.820 0.01 20 0.671 P04424 D31N Disease 0.775 0.886 0.00 63 0.919 P04424 R95C Disease 0.836 0.838 0.02 28 0.840 P04424 M382R Disease 0.891 0.770 0.00 52 0.921 P04424 Q286R Disease 0.725 0.889 0.00 26 0.842 P04424 R111W Disease 0.981 0.922 0.00 66 0.928 P04424 R113Q Disease 0.795 0.942 0.00 62 0.905 P04424 R186Q Disease 0.760 0.938 0.00 57 0.895 P04424 R193Q Disease 0.653 0.903 0.00 48 0.850 P04424 R236W Disease 0.961 0.932 0.00 71 0.924 P04424 R379C Disease 0.902 0.878 0.00 33 0.865 P04424 R385C Disease 0.949 0.967 0.00 59 0.926 P04424 R456W Disease 0.845 0.884 0.00 38 0.877 P04424 V178M Disease 0.531 0.339 0.24 -21 0.400 P04424 V335L Disease 0.331 0.332 0.01 0 0.476 P04439 R89G Polymorphism 0.477 0.778 0.06 16 0.627 P04439 E176V Polymorphism 0.244 0.235 0.50 -20 0.315 P04439 F133L Polymorphism 0.259 0.228 0.84 -26 0.296 P04439 G199R Polymorphism 0.656 0.712 0.08 53 0.791 P04439 I121M Polymorphism 0.221 0.332 0.26 -31 0.192 P04439 R169H Polymorphism 0.507 0.869 0.13 -8 0.600 P04439 R205H Polymorphism 0.767 0.850 0.04 41 0.810 P04439 S129P Polymorphism 0.261 0.575 0.93 -43 0.404 P04440 A84V Polymorphism 0.237 0.263 0.44 -3 0.177 P04440 A85E Polymorphism 0.709 0.866 0.24 56 0.853 P04440 E86D Polymorphism 0.401 0.794 0.37 -8 0.483 P04440 F38Y Polymorphism 0.253 0.355 1.00 -29 0.225 P04440 G40V Polymorphism 0.231 0.258 0.50 0 0.190 P04440 I94F Polymorphism 0.276 0.373 0.57 -18 0.290 P04440 I94L Polymorphism 0.193 0.151 1.00 -37 0.111 P04440 L37V Polymorphism 0.191 0.297 1.00 -19 0.229 P04440 M105V Polymorphism 0.535 0.166 0.70 -10 0.085 P04440 P115A Polymorphism 0.264 0.171 0.22 30 0.273 P04440 V234M Polymorphism 0.774 0.545 0.02 44 0.816 P04626 I654V Polymorphism 0.115 0.489 0.30 -9 0.210 P04626 I655V Polymorphism 0.090 0.230 0.66 -12 0.174 P04626 L768S Polymorphism 0.712 0.879 0.09 36 0.864 P04626 W452C Polymorphism NA 0.375 0.01 59 0.560 P04626 A1216D Polymorphism NA 0.345 0.02 27 0.396 P04626 P1170A Polymorphism NA 0.100 0.02 10 0.143 P04629 G18E Polymorphism NA 0.173 0.01 48 0.210 P04629 L93P Disease 0.724 0.775 0.00 67 0.901 P04629 R85S Polymorphism 0.050 0.125 0.26 1 0.047 P04629 D674Y Disease 0.893 0.772 0.08 42 0.864 P04629 G522R Disease 0.867 0.917 0.00 76 0.936 P04629 G577R Disease 0.867 0.878 0.00 73 0.926 P04629 G613V Polymorphism 0.163 0.277 0.32 10 0.310 P04629 G714S Disease 0.726 0.874 0.00 61 0.921 P04629 H604Y Polymorphism 0.719 0.711 0.06 28 0.820 P04629 L213P Disease 0.732 0.563 0.00 48 0.764 P04629 M587V Disease 0.496 0.244 0.81 7 0.344 P04629 P695L Disease 0.846 0.408 0.02 12 0.658 P04629 R260G Polymorphism 0.181 0.374 0.55 10 0.212 P04629 R444Q Polymorphism 0.386 0.598 0.23 20 0.489 P04629 R452C Polymorphism NA 0.819 0.17 44 0.825 P04629 R649W Disease 0.939 0.918 0.00 64 0.933 P04629 R654C Disease 0.918 0.936 0.00 59 0.935 P04629 R780P Disease 0.466 0.691 0.34 36 0.793 P04629 R780Q Polymorphism 0.326 0.235 0.66 -16 0.261 P04629 T237M Polymorphism 0.386 0.196 0.14 47 0.298 P04629 V790I Polymorphism 0.103 0.200 0.29 -12 0.180 P04637 P47S Polymorphism NA 0.073 0.53 -20 0.071 P04637 P82L Disease NA 0.148 0.16 30 0.122 P04637 A138P Disease 0.914 0.955 0.00 52 0.941 P04637 A138S Disease 0.780 0.715 0.00 24 0.842 P04637 C141Y Disease 0.976 0.943 0.00 60 0.958 P04637 C238G Disease 0.932 0.939 0.00 68 0.951 P04637 C238S Disease 0.935 0.927 0.00 64 0.958 P04637 C275Y Disease 0.981 0.962 0.00 70 0.966 P04637 D281N Disease 0.903 0.819 0.00 71 0.941 P04637 E180K Disease 0.639 0.624 0.01 -1 0.627 P04637 E258K Disease 0.937 0.956 0.00 73 0.953 P04637 E285Q Disease 0.668 0.473 0.01 15 0.659 P04637 E286A Disease 0.901 0.768 0.00 55 0.936 P04637 G105C Disease NA 0.948 0.00 57 0.915 P04637 G244D Disease 0.953 0.910 0.00 70 0.951 P04637 G244V Disease 0.963 0.910 0.00 61 0.956 P04637 G245C Disease 0.973 0.927 0.00 65 0.958 P04637 G245D Disease 0.953 0.938 0.00 75 0.955 P04637 G245S Disease 0.920 0.909 0.00 56 0.864 P04637 G245V Disease 0.963 0.941 0.00 68 0.959 P04637 G325V Disease 0.445 0.338 0.08 2 0.443 P04637 G360A Polymorphism 0.179 0.106 0.56 -5 0.089 P04637 H179Y Disease 0.921 0.929 0.00 74 0.935 P04637 H193R Disease 0.729 0.951 0.00 71 0.937 P04637 H233D Disease 0.529 0.612 0.02 56 0.688 P04637 I251M Disease 0.870 0.905 0.00 49 0.891 P04637 K132E Disease 0.879 0.812 0.00 63 0.938 P04637 K292I Disease 0.605 0.189 0.04 26 0.450 P04637 L252P Disease 0.873 0.963 0.00 24 0.887 P04637 L257Q Disease 0.958 0.968 0.00 59 0.957 P04637 L265P Disease 0.960 0.991 0.00 55 0.952 P04637 L344P Disease 0.819 0.861 0.00 44 0.879 P04637 M133R Disease 0.409 0.506 0.00 44 0.722 P04637 M133T Disease 0.242 0.293 0.00 31 0.392 P04637 M237I Disease 0.812 0.817 0.00 68 0.867 P04637 M246V Disease 0.332 0.757 0.00 50 0.802 P04637 N235S Disease 0.393 0.485 0.30 9 0.407 P04637 P151S Disease 0.934 0.743 0.00 55 0.912 P04637 P151T Disease 0.948 0.761 0.00 53 0.906 P04637 P152L Disease 0.962 0.855 0.00 48 0.890 P04637 P278L Disease 0.968 0.767 0.00 56 0.946 P04637 P278S Disease 0.944 0.801 0.00 58 0.918 P04637 P278T Disease 0.956 0.744 0.00 51 0.912 P04637 P309S Disease 0.102 0.072 0.29 -35 0.105 P04637 Q144L Disease 0.185 0.333 0.16 12 0.236 P04637 Q167K Disease 0.195 0.309 0.01 37 0.390 P04637 R156H Disease 0.392 0.282 0.03 -4 0.382 P04637 R158G Disease 0.922 0.837 0.00 72 0.941 P04637 R158H Disease 0.946 0.881 0.00 71 0.927 P04637 R174G Disease 0.665 0.500 0.00 37 0.768 P04637 R175G Disease 0.940 0.912 0.00 65 0.950 P04637 R175H Disease 0.960 0.906 0.00 62 0.944 P04637 R175L Disease 0.951 0.908 0.00 62 0.951 P04637 R181C Disease 0.917 0.589 0.00 29 0.849 P04637 R181H Disease 0.810 0.478 0.00 6 0.677 P04637 R196P Disease 0.960 0.991 0.00 69 0.949 P04637 R213P Disease 0.951 0.987 0.01 70 0.953 P04637 R213Q Disease 0.903 0.928 0.01 70 0.947 P04637 R248Q Disease 0.923 0.941 0.00 64 0.946 P04637 R248W Disease 0.986 0.960 0.00 69 0.959 P04637 R267Q Disease 0.901 0.937 0.00 61 0.927 P04637 R273C Disease 0.976 0.972 0.00 68 0.958 P04637 R273G Disease 0.922 0.956 0.00 61 0.949 P04637 R273H Disease 0.946 0.938 0.00 59 0.956 P04637 R273L Disease 0.933 0.948 0.00 62 0.952 P04637 R282G Disease 0.922 0.922 0.00 42 0.896 P04637 R282W Disease 0.983 0.945 0.00 46 0.939 P04637 R283C Disease 0.870 0.558 0.00 20 0.756 P04637 R290H Disease 0.247 0.552 0.09 -9 0.402 P04637 R290L Disease 0.299 0.561 0.06 0 0.439 P04637 R306P Disease 0.662 0.833 0.01 10 0.817 P04637 R337C Disease 0.725 0.469 0.00 44 0.573 P04637 R337H Disease 0.542 0.353 0.01 14 0.511 P04637 S227T Disease 0.198 0.371 0.28 -32 0.234 P04637 S241F Disease 0.960 0.917 0.00 71 0.958 P04637 S241T Disease 0.844 0.849 0.00 69 0.899 P04637 T155N Disease 0.426 0.280 0.02 15 0.372 P04637 V172F Disease 0.724 0.758 0.00 52 0.875 P04637 V173M Disease 0.897 0.804 0.00 52 0.893 P04637 V197M Disease 0.897 0.734 0.06 43 0.834 P04637 V217M Polymorphism 0.468 0.353 0.02 -4 0.305 P04637 V272L Disease 0.410 0.630 0.01 47 0.586 P04637 Y163C Disease 0.974 0.830 0.00 58 0.956 P04637 Y220C Disease 0.974 0.813 0.00 55 0.945 P04637 Y234C Disease 0.855 0.780 0.00 55 0.933 P04637 Y236C Disease 0.882 0.572 0.00 56 0.919 P04792 P182L Disease 0.761 0.859 0.00 -1 0.843 P04792 R127W Disease 0.829 0.852 0.00 44 0.882 P04792 R136W Disease 0.994 0.953 0.00 67 0.953 P04792 S135F Disease 0.788 0.885 0.03 33 0.784 P04792 T151I Disease 0.441 0.111 0.16 -23 0.249 P04798 G45D Polymorphism 0.673 0.726 0.07 25 0.838 P04798 R93W Polymorphism 0.885 0.932 0.00 37 0.916 P04798 I462V Polymorphism 0.222 0.190 0.16 -13 0.183 P04798 P492R Polymorphism NA 0.766 0.09 19 0.662 P04798 R279W Polymorphism 0.906 0.948 0.00 58 0.940 P04798 T461N Polymorphism 0.119 0.566 0.43 -11 0.069 P04798 V482M Polymorphism NA 0.347 0.09 -28 0.396 P04839 A55D Disease 0.895 0.938 0.01 57 0.946 P04839 A57E Disease 0.891 0.960 0.01 56 0.943 P04839 C59R Disease 0.882 0.909 0.04 55 0.937 P04839 C59W Disease 0.957 0.856 0.01 48 0.903 P04839 G20R Disease 0.479 0.931 0.53 25 0.807 P04839 R54M Disease 0.959 0.822 0.01 67 0.953 P04839 R54S Disease 0.890 0.856 0.02 63 0.936 P04839 W18C Disease 0.969 0.906 0.00 51 0.951 P04839 Y41D Disease 0.932 0.900 0.03 73 0.912 P04839 A156T Disease NA 0.401 0.14 12 0.337 P04839 A224G Disease NA 0.650 0.33 -6 0.311 P04839 C244R Disease NA 0.874 0.31 50 0.878 P04839 C244S Disease NA 0.863 0.64 41 0.743 P04839 C244Y Disease NA 0.871 0.12 54 0.789 P04839 C537R Disease 0.994 0.985 0.00 79 0.919 P04839 D500G Disease 0.709 0.881 0.02 58 0.855 P04839 D517E Polymorphism 0.137 0.689 0.47 -10 0.141 P04839 E225V Disease NA 0.679 0.51 11 0.622 P04839 E309K Disease 0.839 0.746 0.62 0 0.813 P04839 F205I Disease 0.995 0.905 0.00 50 0.956 P04839 G179R Disease 0.841 0.952 0.00 70 0.944 P04839 G223L Disease 0.884 0.945 0.04 50 0.924 P04839 G322E Disease 0.995 0.832 0.00 70 0.953 P04839 G364R Polymorphism 0.472 0.760 0.59 0 0.522 P04839 G389A Disease 0.994 0.882 0.00 62 0.960 P04839 G389E Disease 0.997 0.937 0.00 75 0.958 P04839 G408E Disease 0.642 0.960 0.00 67 0.941 P04839 G408R Disease 0.719 0.968 0.00 68 0.939 P04839 G472S Polymorphism 0.090 0.801 0.50 -21 0.176 P04839 H101R Disease 0.994 0.959 0.00 54 0.961 P04839 H101Y Disease 0.992 0.973 0.00 38 0.936 P04839 H119R Disease 0.918 0.957 0.00 36 0.910 P04839 H209Q Disease 0.997 0.898 0.00 60 0.961 P04839 H209R Disease 0.996 0.927 0.00 66 0.962 P04839 H209Y Disease 0.995 0.936 0.00 61 0.962 P04839 H222N Disease 0.997 0.939 0.00 74 0.958 P04839 H222R Disease 0.996 0.938 0.00 78 0.939 P04839 H222Y Disease 0.995 0.945 0.00 70 0.958 P04839 H303N Disease 0.916 0.705 0.16 35 0.861 P04839 H338Y Disease 0.995 0.917 0.00 78 0.944 P04839 I325F Disease 0.463 0.790 0.03 43 0.781 P04839 L342Q Disease 0.936 0.717 0.01 27 0.864 P04839 L420P Disease 0.943 0.978 0.01 52 0.919 P04839 L505R Disease 0.931 0.906 0.04 66 0.944 P04839 L546P Disease 0.932 0.955 0.00 51 0.941 P04839 M405R Disease 0.564 0.880 0.01 57 0.898 P04839 P304R Disease 0.943 0.895 0.01 26 0.910 P04839 P339H Disease 0.618 0.893 0.00 75 0.919 P04839 P415H Disease 0.998 0.945 0.00 63 0.961 P04839 P415L Disease 0.997 0.934 0.01 46 0.910 P04839 R356P Disease 0.853 0.939 0.00 52 0.933 P04839 S193F Disease 0.811 0.854 0.00 59 0.926 P04839 S333P Disease 0.890 0.948 0.01 43 0.908 P04839 S344F Disease 0.856 0.906 0.00 58 0.937 P04839 S422P Disease 0.766 0.944 0.04 47 0.882 P04839 T307P Disease NA 0.761 0.01 37 0.842 P04839 V534D Disease 0.993 0.984 0.00 67 0.956 P04839 W453R Disease 0.995 0.933 0.00 69 0.958 P04839 W516C Disease 0.970 0.959 0.00 67 0.959 P04839 W516R Disease 0.943 0.964 0.00 72 0.948 P04844 L597F Polymorphism 0.369 0.505 NA 22 0.515 P04920 L1204F Polymorphism 0.523 0.766 0.06 -1 0.597 P05000 R95S Polymorphism 0.403 0.151 0.90 -3 0.206 P05014 A74T Polymorphism 0.562 0.344 0.15 -29 0.513 P05014 H49P Polymorphism 0.515 0.264 1.00 0 0.005 P05014 E137V Polymorphism 0.588 0.786 0.20 35 0.645 P05019 A115T Polymorphism 0.110 0.367 0.13 -16 0.224 P05019 A187D Polymorphism 0.139 0.222 NA -1 0.034 P05023 S47I Polymorphism 0.370 0.282 0.01 0 0.438 P05060 S93T Polymorphism 0.488 0.046 0.39 9 0.046 P05060 A353G Polymorphism 0.387 0.093 0.31 -26 0.050 P05060 N200H Polymorphism 0.767 0.079 0.07 25 0.099 P05060 R178Q Polymorphism 0.443 0.085 0.59 24 0.048 P05060 R232Q Polymorphism 0.586 0.178 0.35 26 0.137 P05060 R417H Polymorphism 0.577 0.156 0.26 18 0.043 P05062 I74T Disease 0.772 0.935 0.00 46 0.897 P05062 A150P Disease 0.678 0.945 0.06 11 0.861 P05062 A175D Disease 0.883 0.951 0.00 51 0.932 P05062 A338V Disease 0.740 0.962 0.00 52 0.919 P05062 C135R Disease 0.691 0.939 0.01 44 0.879 P05062 C178R Disease 0.858 0.981 0.00 59 0.943 P05062 I268N Polymorphism 0.914 0.972 0.00 42 0.910 P05062 L229P Disease 0.944 0.974 0.00 44 0.914 P05062 L257P Disease 0.943 0.962 0.02 55 0.945 P05062 L284P Disease 0.946 0.976 0.00 55 0.950 P05062 N335K Disease 0.764 0.944 0.00 65 0.943 P05062 P185R Disease 0.945 0.900 0.00 58 0.940 P05062 R304Q Disease 0.789 0.973 0.00 58 0.938 P05062 R304W Disease 0.969 0.973 0.00 61 0.956 P05062 V222F Disease 0.829 0.958 0.00 41 0.890 P05067 A692G Disease 0.488 0.222 0.40 43 0.237 P05067 A713T Disease 0.728 0.751 0.05 37 0.823 P05067 A713V Polymorphism 0.792 0.757 0.05 34 0.720 P05067 D678N Disease 0.173 0.105 0.50 8 0.166 P05067 D694N Disease 0.325 0.524 0.80 50 0.724 P05067 E693G Disease 0.425 0.554 0.08 45 0.612 P05067 E693K Disease 0.356 0.537 0.17 41 0.537 P05067 E693Q Disease 0.376 0.596 0.14 43 0.664 P05067 I716V Disease 0.417 0.630 0.16 6 0.470 P05067 L705V Disease 0.710 0.703 0.12 44 0.854 P05067 L723P Disease 0.932 0.966 0.01 29 0.908 P05067 T714A Disease 0.282 0.727 0.15 17 0.457 P05067 T714I Disease 0.537 0.778 0.09 21 0.597 P05067 V715M Disease 0.494 0.719 0.04 -18 0.570 P05067 V717F Disease 0.859 0.836 0.01 23 0.870 P05067 V717G Disease 0.877 0.873 0.00 38 0.883 P05067 V717I Disease 0.501 0.540 0.12 14 0.464 P05067 V717L Disease 0.628 0.815 0.17 -3 0.811 P05089 I11T Disease NA 0.594 0.00 51 0.640 P05089 G138V Disease 0.904 0.806 0.00 67 0.899 P05089 G235R Disease 0.821 0.829 0.01 30 0.844 P05089 T290S Polymorphism 0.161 0.444 0.63 -33 0.234 P05090 T178K Polymorphism NA 0.206 0.03 -29 0.194 P05091 E504K Polymorphism 0.327 0.622 0.18 10 0.484 P05093 C22W Polymorphism 0.575 0.320 0.19 11 0.555 P05093 F93C Disease 0.981 0.951 0.00 43 0.932 P05093 P35L Disease 0.976 0.728 0.00 23 0.879 P05093 R96W Disease 0.988 0.956 0.00 61 0.947 P05093 Y64S Disease 0.786 0.500 0.00 40 0.740 P05093 D116V Disease 0.705 0.739 0.00 49 0.853 P05093 F114V Disease 0.711 0.825 0.01 43 0.694 P05093 F417C Disease 0.981 0.901 0.00 53 0.762 P05093 H373L Disease 0.965 0.915 0.00 58 0.708 P05093 N177D Disease 0.906 0.773 0.02 61 0.835 P05093 P342T Disease 0.824 0.681 0.02 20 0.781 P05093 P428L Disease 0.863 0.537 0.01 3 0.688 P05093 R347C Disease 0.926 0.681 0.00 53 0.760 P05093 R347H Disease 0.829 0.646 0.00 41 0.816 P05093 R358Q Disease 0.464 0.202 0.26 -28 0.178 P05093 R362C Disease 0.926 0.871 0.00 70 0.710 P05093 R440H Disease 0.964 0.887 0.00 70 0.831 P05093 R496C Disease NA 0.972 0.00 73 0.941 P05093 R496H Disease NA 0.909 0.00 68 0.919 P05093 S106P Disease 0.651 0.902 0.01 14 0.820 P05093 W406R Disease 0.977 0.884 0.00 62 0.731 P05093 Y329D Disease 0.201 0.792 0.14 9 0.414 P05106 L59P Polymorphism NA 0.426 0.31 -40 0.211 P05106 L66R Polymorphism NA 0.534 0.16 33 0.501 P05106 C400Y Disease 0.989 0.969 0.00 38 0.941 P05106 C532Y Disease 0.974 0.940 0.00 71 0.956 P05106 C568R Disease 0.962 0.919 0.00 71 0.954 P05106 C586F Disease 0.968 0.936 0.00 45 0.922 P05106 C586R Disease 0.962 0.942 0.00 47 0.928 P05106 C601R Disease 0.961 0.946 0.00 83 0.947 P05106 D145N Disease 0.926 0.950 0.00 61 0.946 P05106 D145Y Disease 0.983 0.972 0.00 64 0.955 P05106 D243V Disease 0.980 0.957 0.00 58 0.958 P05106 G598S Disease 0.804 0.777 0.04 28 0.783 P05106 G605S Disease 0.910 0.864 0.00 62 0.935 P05106 H306P Disease 0.320 0.685 0.21 -19 0.419 P05106 I330N Disease 0.841 0.925 0.00 22 0.886 P05106 L143W Disease 0.969 0.922 0.00 51 0.944 P05106 L222P Disease 0.977 0.986 0.00 47 0.929 P05106 L288P Disease 0.912 0.988 0.00 42 0.903 P05106 M150V Disease 0.902 0.909 0.00 63 0.913 P05106 M321L Disease 0.127 0.151 1.00 -37 0.063 P05106 R119W Disease NA 0.968 0.00 48 0.880 P05106 R169Q Polymorphism 0.385 0.242 0.30 -33 0.289 P05106 R240Q Disease 0.670 0.500 0.03 25 0.738 P05106 R240W Disease 0.936 0.689 0.00 12 0.807 P05106 R242Q Disease 0.670 0.434 0.01 -2 0.608 P05106 R515Q Polymorphism 0.085 0.254 0.48 12 0.152 P05106 S188L Disease 0.815 0.483 1.00 2 0.654 P05106 S778P Disease 0.807 0.916 0.01 4 0.869 P05106 Y141C Disease 0.970 0.932 0.00 52 0.950 P05107 D128N Disease 0.866 0.980 0.00 55 0.914 P05107 G169R Disease 0.942 0.960 0.00 73 0.933 P05107 G273R Disease 0.941 0.966 0.01 62 0.945 P05107 G284S Disease 0.870 0.899 0.00 34 0.890 P05107 K196T Disease NA 0.259 0.47 -19 0.195 P05107 L149P Disease 0.974 0.932 0.00 58 0.952 P05107 N351S Disease 0.870 0.941 0.00 23 0.884 P05107 P178L Disease 0.561 0.901 0.00 36 0.856 P05107 Q354H Polymorphism 0.096 0.493 0.00 5 0.371 P05107 R586W Disease 0.748 0.583 0.01 40 0.755 P05107 R593C Disease 0.851 0.907 0.00 42 0.881 P05107 S138P Disease 0.943 0.943 0.00 65 0.944 P05108 A189V Disease NA 0.203 0.03 12 0.357 P05108 E314K Polymorphism 0.115 0.660 0.35 0 0.093 P05108 R353W Disease 0.974 0.947 0.00 22 0.916 P05111 G227R Polymorphism NA 0.167 0.04 24 0.130 P05120 R229H Polymorphism 0.296 0.413 0.08 -20 0.381 P05120 S413C Polymorphism 0.584 0.695 0.26 -28 0.482 P05121 H25P Polymorphism NA 0.400 0.27 7 0.319 P05121 V17I Polymorphism NA 0.207 0.11 -25 0.209 P05129 A523D Polymorphism 0.923 0.889 0.00 63 0.800 P05129 G128D Disease 0.923 0.932 0.01 65 0.947 P05129 H101Y Disease NA 0.944 0.00 66 0.933 P05129 R141C Polymorphism 0.916 0.801 0.00 55 0.924 P05129 S119P Disease 0.682 0.941 0.14 68 0.933 P05154 S44G Polymorphism NA 0.589 0.32 -21 0.449 P05154 K105E Polymorphism 0.082 0.552 0.25 -36 0.022 P05154 L115P Polymorphism 0.782 0.869 0.00 39 0.874 P05154 P121A Polymorphism 0.533 0.156 0.02 5 0.306 P05155 A456E Disease 0.551 0.908 0.03 35 0.736 P05155 A458T Disease 0.395 0.873 0.01 40 0.643 P05155 A458V Disease 0.438 0.890 0.03 27 0.615 P05155 A465V Disease 0.278 0.351 0.34 0 0.290 P05155 C130Y Disease NA 0.594 0.06 54 0.606 P05155 D408V Disease 0.685 0.734 0.05 34 0.840 P05155 F477S Disease 0.946 0.758 0.00 50 0.919 P05155 G345R Disease 0.718 0.815 0.02 34 0.852 P05155 G429R Disease 0.721 0.826 0.08 45 0.655 P05155 G493E Disease 0.960 0.904 0.00 71 0.931 P05155 L481P Disease 0.672 0.877 0.00 34 0.880 P05155 L481R Disease 0.378 0.809 0.00 52 0.877 P05155 P489R Disease 0.692 0.702 0.03 49 0.893 P05155 P498R Disease 0.999 0.894 0.00 58 0.958 P05155 P498S Disease 0.999 0.911 0.00 55 0.959 P05155 Q474E Polymorphism 0.197 0.566 0.22 35 0.269 P05155 R466C Disease 0.677 0.837 0.06 23 0.825 P05155 R466H Disease 0.469 0.715 0.15 27 0.634 P05155 R466L Disease 0.388 0.707 0.34 35 0.537 P05155 R466S Disease 0.272 0.397 0.76 35 0.348 P05155 T394P Disease NA 0.329 0.06 -3 0.435 P05155 T467P Disease 0.252 0.788 0.28 11 0.344 P05155 V454E Disease 0.661 0.728 0.01 16 0.761 P05155 V473E Disease 0.661 0.656 0.00 61 0.869 P05155 V473M Disease 0.533 0.417 0.04 52 0.654 P05155 V480M Polymorphism 0.226 0.254 0.23 -2 0.172 P05156 G243D Disease 0.442 0.868 0.12 49 0.828 P05156 H418L Disease 0.605 0.887 0.00 70 0.873 P05160 D569E Polymorphism 0.264 0.320 0.63 13 0.314 P05160 E388V Polymorphism 0.540 0.437 0.20 48 0.553 P05160 L529P Polymorphism 0.531 0.330 0.33 -28 0.456 P05160 R115H Polymorphism 0.117 0.398 0.12 27 0.179 P05160 Y543S Polymorphism 0.525 0.408 0.00 59 0.790 P05164 V53F Polymorphism NA 0.123 0.33 -38 0.191 P05164 E683Q Polymorphism 0.114 0.661 0.42 -30 0.079 P05164 I717V Polymorphism 0.085 0.166 1.00 -47 0.082 P05164 M251T Disease 0.457 0.736 0.01 36 0.647 P05164 R569W Disease 0.955 0.896 0.03 23 0.921 P05164 Y173C Disease 0.979 0.952 0.00 55 0.953 P05166 L17M Disease NA 0.374 0.14 33 0.202 P05166 R44P Disease NA 0.608 0.16 39 0.789 P05166 R67S Disease 0.707 0.869 0.03 40 0.698 P05166 A153P Disease 0.703 0.939 0.33 10 0.861 P05166 A468T Disease 0.582 0.938 0.00 42 0.774 P05166 A497V Disease 0.506 0.846 0.06 14 0.523 P05166 E168K Disease 0.493 0.912 0.28 49 0.886 P05166 G112D Disease 0.783 0.877 0.00 65 0.921 P05166 G131R Disease 0.994 0.909 0.00 79 0.947 P05166 G188R Disease 0.925 0.939 0.05 48 0.860 P05166 G198D Disease 0.959 0.923 0.00 68 0.949 P05166 G246V Disease NA 0.897 0.00 54 0.903 P05166 I430L Disease 0.420 0.512 0.11 30 0.570 P05166 L519P Disease 0.907 0.933 0.01 50 0.933 P05166 M442T Disease 0.719 0.914 0.00 54 0.916 P05166 N536D Disease 0.418 0.904 0.06 40 0.847 P05166 P228L Disease 0.965 0.915 0.00 49 0.938 P05166 R165Q Disease 0.610 0.841 0.13 59 0.895 P05166 R165W Disease 0.887 0.946 0.01 59 0.935 P05166 R410W Disease 0.916 0.949 0.00 24 0.905 P05166 R512C Disease 0.979 0.896 0.00 63 0.946 P05166 S106R Disease 0.691 0.849 0.01 31 0.906 P05166 T428I Disease 0.757 0.858 0.00 26 0.877 P05166 V107M Disease 0.670 0.845 0.01 33 0.803 P05166 V205D Disease 0.808 0.943 0.02 66 0.937 P05166 Y435C Disease 0.928 0.915 0.00 63 0.934 P05166 Y439C Disease 0.894 0.912 0.06 54 0.925 P05177 F21L Polymorphism 0.230 0.658 0.43 -9 0.354 P05177 G73R Polymorphism 0.976 0.803 0.00 71 0.938 P05177 P42R Polymorphism 0.664 0.835 0.06 64 0.913 P05177 T83M Polymorphism 0.531 0.331 0.23 -8 0.495 P05177 C406Y Polymorphism 0.782 0.651 0.01 1 0.700 P05177 F186L Polymorphism 0.282 0.730 0.23 25 0.462 P05177 F205V Polymorphism 0.942 0.911 0.00 62 0.934 P05177 G299S Polymorphism 0.148 0.413 0.56 -36 0.174 P05177 I314V Polymorphism 0.209 0.232 0.02 3 0.226 P05177 I386F Polymorphism 0.672 0.331 0.00 43 0.666 P05177 L111F Polymorphism 0.673 0.338 0.18 -8 0.576 P05177 R281W Polymorphism 0.906 0.948 0.00 67 0.941 P05177 R377Q Polymorphism 0.609 0.728 0.00 69 0.909 P05177 R456H Polymorphism 0.964 0.939 0.00 72 0.947 P05177 R457W Polymorphism 0.900 0.908 0.01 38 0.871 P05177 S212C Polymorphism 0.619 0.297 0.02 17 0.585 P05177 T438I Polymorphism 0.460 0.330 0.01 -9 0.403 P05181 R76H Polymorphism 0.692 0.842 0.03 7 0.847 P05181 H457L Polymorphism 0.616 0.626 0.01 28 0.762 P05181 S366C Polymorphism 0.714 0.269 0.05 7 0.551 P05186 A33V Disease NA 0.540 0.30 38 0.533 P05186 A40V Disease NA 0.217 0.02 17 0.342 P05186 A51S Disease NA 0.795 0.01 34 0.747 P05186 A51V Disease NA 0.857 0.15 23 0.663 P05186 G63R Disease NA 0.969 0.00 64 0.940 P05186 G63V Disease NA 0.930 0.01 52 0.894 P05186 G75S Disease NA 0.902 0.02 25 0.732 P05186 M62L Disease NA 0.939 0.08 34 0.715 P05186 M62V Disease NA 0.952 0.01 58 0.920 P05186 Q76R Disease NA 0.663 0.11 29 0.523 P05186 R71C Disease NA 0.934 0.00 63 0.939 P05186 R71H Disease NA 0.895 0.00 57 0.897 P05186 R71P Disease NA 0.932 0.00 75 0.940 P05186 R71S Disease NA 0.909 0.00 55 0.803 P05186 S17F Disease NA 0.281 0.03 2 0.395 P05186 T68M Disease NA 0.589 0.01 31 0.790 P05186 Y28C Disease NA 0.640 0.00 53 0.720 P05186 A111T Disease NA 0.899 0.01 45 0.870 P05186 A114G Disease NA 0.862 0.18 -7 0.569 P05186 A116T Disease NA 0.922 0.00 46 0.875 P05186 A132V Disease 0.748 0.780 0.18 1 0.802 P05186 A176T Disease 0.404 0.849 0.02 38 0.729 P05186 A177T Disease 0.305 0.752 1.00 -51 0.435 P05186 A179T Disease 0.404 0.869 0.01 52 0.790 P05186 A348T Disease 0.701 0.856 0.04 3 0.803 P05186 A399S Disease 0.594 0.353 0.24 -30 0.554 P05186 A468T Disease 0.668 0.396 0.06 36 0.656 P05186 C201Y Disease 0.940 0.832 0.03 33 0.865 P05186 C489S Disease 0.814 0.581 0.00 17 0.730 P05186 D189E Disease 0.644 0.817 0.26 13 0.753 P05186 D294A Disease 0.538 0.648 0.10 26 0.541 P05186 D294Y Disease 0.803 0.792 0.13 37 0.862 P05186 D306V Disease 0.907 0.819 0.17 18 0.868 P05186 D378V Disease 0.991 0.915 0.00 69 0.954 P05186 D406G Disease 0.770 0.809 0.03 20 0.811 P05186 E191G Disease 0.354 0.424 0.02 8 0.427 P05186 E191K Disease 0.229 0.564 0.24 -2 0.385 P05186 E235G Disease 0.785 0.608 0.02 9 0.779 P05186 E291K Disease 0.348 0.838 0.24 50 0.799 P05186 E298K Disease 0.314 0.851 0.22 21 0.615 P05186 E311K Disease 0.455 0.919 0.03 44 0.809 P05186 E354D Disease 0.202 0.746 0.53 -34 0.415 P05186 E452K Disease 0.774 0.821 0.03 61 0.866 P05186 E476K Disease 0.763 0.734 0.03 55 0.904 P05186 F327G Disease 0.896 0.893 0.00 45 0.909 P05186 F327L Disease 0.679 0.891 0.00 38 0.873 P05186 G120R Disease NA 0.952 0.00 72 0.941 P05186 G129R Disease NA 0.950 0.00 68 0.938 P05186 G162S Disease 0.982 0.913 0.00 49 0.945 P05186 G162V Disease 0.992 0.915 0.00 48 0.921 P05186 G220A Disease 0.978 0.863 0.00 43 0.912 P05186 G220V Disease 0.992 0.890 0.00 60 0.954 P05186 G249V Disease 0.723 0.900 0.00 41 0.874 P05186 G326R Disease 0.977 0.957 0.00 61 0.955 P05186 G334D Disease 0.897 0.871 0.01 65 0.927 P05186 G339R Disease 0.910 0.909 0.23 55 0.937 P05186 G426C Disease 0.819 0.747 0.01 3 0.829 P05186 G426D Disease 0.665 0.553 0.27 20 0.766 P05186 G456R Disease 0.923 0.856 0.00 61 0.937 P05186 G473S Disease 0.941 0.771 0.00 51 0.897 P05186 G491R Disease 0.736 0.678 0.12 66 0.912 P05186 H171R Disease 0.519 0.906 0.03 61 0.906 P05186 H171Y Disease 0.529 0.853 0.02 56 0.892 P05186 H381R Disease 0.522 0.851 0.00 61 0.899 P05186 I212F Disease 0.492 0.628 0.31 -14 0.375 P05186 I490F Disease 0.479 0.371 0.05 -27 0.358 P05186 K224E Disease 0.347 0.566 0.12 23 0.474 P05186 L275P Disease 0.970 0.935 0.00 46 0.941 P05186 L289F Disease 0.290 0.913 0.00 55 0.887 P05186 L299P Disease 0.620 0.845 0.04 23 0.743 P05186 L414M Disease 0.673 0.326 0.09 -25 0.565 P05186 M295T Disease 0.446 0.892 0.19 58 0.838 P05186 N170D Disease 0.276 0.732 0.33 27 0.402 P05186 N211D Disease 0.703 0.394 0.27 -36 0.555 P05186 N417S Disease 0.756 0.631 0.02 42 0.784 P05186 N478I Disease 0.684 0.223 0.01 30 0.604 P05186 P108L Disease NA 0.860 0.02 46 0.866 P05186 P292T Disease 0.878 0.595 0.12 -23 0.751 P05186 Q207P Disease 0.965 0.906 0.02 57 0.955 P05186 R136H Disease 0.661 0.554 0.59 -7 0.743 P05186 R152H Disease 0.430 0.792 0.29 -56 0.550 P05186 R184W Disease 0.877 0.878 0.00 67 0.926 P05186 R223Q Disease 0.639 0.800 0.19 46 0.783 P05186 R223W Disease 0.943 0.876 0.01 35 0.851 P05186 R246S Disease 0.940 0.903 0.01 49 0.917 P05186 R272H Disease 0.482 0.741 0.02 38 0.669 P05186 R272L Disease 0.456 0.763 0.09 26 0.640 P05186 R391C Disease 0.951 0.925 0.01 60 0.949 P05186 R391H Disease 0.884 0.814 0.14 55 0.901 P05186 R450C Disease 0.725 0.569 0.05 43 0.775 P05186 R450H Disease 0.497 0.210 0.12 -4 0.317 P05186 S181L Disease 0.404 0.808 0.17 4 0.753 P05186 S445P Disease 0.500 0.650 0.05 45 0.791 P05186 T134H Disease 0.503 0.519 0.02 5 0.502 P05186 T134N Disease 0.338 0.574 0.05 -5 0.451 P05186 T148I Disease 0.435 0.468 0.64 -10 0.329 P05186 T411A Disease 0.577 0.469 0.15 -14 0.586 P05186 V128M Disease NA 0.738 0.03 16 0.522 P05186 V382I Disease 0.393 0.150 0.17 32 0.275 P05186 V423A Disease 0.351 0.088 0.02 -30 0.180 P05186 V459M Disease 0.919 0.751 0.01 45 0.890 P05186 V522A Polymorphism 0.023 0.100 NA -70 0.040 P05186 Y263H Polymorphism 0.170 0.398 0.72 -14 0.241 P05186 Y297D Disease 0.737 0.885 0.04 49 0.853 P05186 Y436H Disease 0.464 0.242 0.54 2 0.363 P05187 P25L Polymorphism NA 0.601 0.02 15 0.671 P05187 E451G Polymorphism 0.087 0.355 0.12 29 0.247 P05187 R231P Polymorphism 0.350 0.630 0.76 -42 0.361 P05187 R263H Polymorphism 0.229 0.702 0.61 -36 0.315 P05230 G21E Polymorphism 0.325 0.449 0.01 26 0.355 P05231 P32S Polymorphism 0.095 0.180 0.23 -8 0.048 P05231 D162V Polymorphism 0.481 0.173 0.39 8 0.124 P05305 K198N Polymorphism 0.128 0.122 0.02 6 0.138 P05305 V186I Polymorphism 0.093 0.027 1.00 -67 0.010 P05362 K155N Polymorphism 0.251 0.218 0.01 32 0.317 P05362 K469E Polymorphism 0.158 0.128 1.00 -16 0.026 P05362 V315M Polymorphism 0.320 0.084 0.09 30 0.154 P05412 T297M Polymorphism 0.674 0.486 0.08 3 0.605 P05452 A55S Polymorphism 0.096 0.029 0.87 -15 0.099 P05534 E86G Polymorphism 0.358 0.388 0.12 10 0.382 P05534 G89R Polymorphism 0.477 0.300 0.38 -20 0.227 P05534 G131W Polymorphism 0.626 0.870 0.07 46 0.719 P05534 L119V Polymorphism 0.407 0.647 0.18 -9 0.444 P05534 M121R Polymorphism 0.488 0.725 0.39 22 0.288 P05534 Q180L Polymorphism 0.221 0.374 0.78 -5 0.199 P05534 R205H Polymorphism 0.767 0.850 0.03 29 0.808 P05534 T206A Polymorphism 0.237 0.078 1.00 -20 0.123 P05543 S43T Disease NA 0.586 0.42 -23 0.423 P05543 A133P Disease 0.500 0.878 0.01 51 0.889 P05543 H351Y Disease 0.983 0.950 0.00 61 0.946 P05543 I116N Disease 0.679 0.543 0.00 -47 0.371 P05543 L247P Disease 0.601 0.801 0.07 8 0.782 P05543 L303F Polymorphism 0.449 0.690 0.01 13 0.725 P05543 P383L Disease 0.419 0.669 0.75 -10 0.447 P05546 E447K Disease 0.998 0.883 0.01 54 0.938 P05546 K237R Polymorphism 0.100 0.132 0.82 -44 0.107 P05546 L129V Polymorphism NA 0.491 1.00 -1 0.307 P05546 P462L Disease 0.709 0.309 0.75 -35 0.510 P05546 R208H Disease 0.713 0.466 0.08 -4 0.642 P05549 G262E Disease 0.812 0.791 0.00 57 0.923 P05549 L249P Disease 0.935 0.974 0.00 55 0.951 P05549 R254G Disease 0.871 0.846 0.00 38 0.877 P05549 R255G Disease 0.861 0.837 0.00 61 0.932 P05783 G340R Disease 0.386 0.728 0.45 -16 0.435 P05783 H128L Disease 0.510 0.243 0.48 -14 0.457 P05783 R261Q Disease 0.376 0.160 0.39 -43 0.132 P05783 T103A Disease 0.263 0.137 0.34 -53 0.161 P05787 G53V Disease 0.552 0.211 0.11 2 0.486 P05787 G62C Disease 0.514 0.738 0.19 7 0.531 P05787 Y54C Disease 0.494 0.217 0.18 5 0.351 P05787 R401W Polymorphism 0.993 0.827 0.01 46 0.904 P05997 G963R Disease 0.990 0.808 NA 74 0.985 P05997 P460S Polymorphism 0.105 0.329 NA 6 0.240 P05997 R956P Polymorphism 0.646 0.787 NA 0 0.628 P05997 T1230S Polymorphism NA 0.264 NA -16 0.297 P06028 T84S Polymorphism 0.077 0.051 1.00 0 0.035 P06132 A80G Disease 0.263 0.800 0.00 0 0.490 P06132 A80S Disease 0.380 0.848 0.00 36 0.734 P06132 F46L Disease 0.416 0.873 0.00 32 0.830 P06132 G25E Disease NA 0.925 0.10 26 0.835 P06132 P62L Disease 0.496 0.856 0.00 38 0.859 P06132 E167K Disease 0.273 0.925 0.00 54 0.753 P06132 E218K Disease 0.429 0.888 0.00 69 0.908 P06132 F229L Disease 0.574 0.900 0.00 40 0.875 P06132 F232L Disease 0.307 0.927 0.00 44 0.625 P06132 G156D Disease 0.751 0.951 0.00 75 0.835 P06132 G281E Disease 0.407 0.942 0.00 59 0.913 P06132 G281V Disease 0.555 0.931 0.00 40 0.871 P06132 G303S Disease 0.692 0.939 0.00 59 0.932 P06132 G318R Disease 0.162 0.777 1.00 -38 0.170 P06132 H220P Disease 0.285 0.847 0.00 46 0.671 P06132 I260T Disease 0.162 0.737 0.05 11 0.250 P06132 I334T Disease 0.651 0.895 0.00 53 0.895 P06132 L161Q Disease 0.874 0.893 0.00 42 0.832 P06132 L195F Disease 0.234 0.884 0.03 14 0.449 P06132 L216Q Disease 0.761 0.867 0.00 33 0.864 P06132 L253Q Disease NA 0.459 0.04 -24 0.442 P06132 L282R Disease 0.604 0.949 0.00 61 0.927 P06132 M165R Disease 0.487 0.927 0.00 62 0.858 P06132 M324T Disease 0.189 0.790 0.19 0 0.344 P06132 N304K Disease 0.502 0.938 0.00 67 0.950 P06132 P235S Disease 0.382 0.797 0.32 -18 0.614 P06132 R142Q Disease 0.306 0.914 0.00 23 0.555 P06132 R144P Disease 0.319 0.841 0.03 39 0.523 P06132 R193P Disease 0.226 0.792 0.02 31 0.520 P06132 R292G Disease 0.443 0.897 0.00 34 0.753 P06132 R332H Disease 0.250 0.762 0.07 2 0.402 P06132 S219F Disease 0.850 0.905 0.00 60 0.929 P06132 V134Q Disease 0.400 0.926 0.00 45 0.719 P06132 Y311C Disease 0.729 0.841 0.00 40 0.871 P06133 F396L Polymorphism 0.903 0.849 0.03 14 0.808 P06213 D86G Disease NA 0.743 0.01 30 0.547 P06213 G58R Disease NA 0.957 0.00 64 0.946 P06213 L89P Disease NA 0.980 0.00 50 0.889 P06213 N42K Disease NA 0.882 0.02 43 0.822 P06213 V55A Disease NA 0.799 0.00 40 0.795 P06213 A119V Disease NA 0.854 0.00 49 0.865 P06213 C280Y Disease 0.826 0.984 0.00 54 0.950 P06213 C301Y Disease 0.246 0.469 0.26 23 0.286 P06213 F409V Disease NA 0.644 0.06 37 0.756 P06213 G386S Disease NA 0.710 0.18 -19 0.495 P06213 G393R Disease NA 0.897 0.05 55 0.895 P06213 G811S Polymorphism 0.408 0.354 0.34 -17 0.298 P06213 H236R Disease 0.631 0.660 0.03 48 0.793 P06213 I146M Disease 0.325 0.910 0.01 51 0.849 P06213 I925T Disease 0.314 0.453 0.01 27 0.538 P06213 K487E Disease 0.336 0.233 1.00 31 0.258 P06213 L120Q Disease NA 0.968 0.00 58 0.930 P06213 L260P Disease 0.326 0.680 0.11 14 0.623 P06213 N458D Disease NA 0.919 0.00 63 0.926 P06213 N489S Disease 0.334 0.827 0.00 20 0.584 P06213 P997T Disease 0.703 0.724 0.21 36 0.820 P06213 Q492K Polymorphism 0.082 0.272 0.24 11 0.190 P06213 R113P Disease NA 0.860 0.19 48 0.849 P06213 R279C Disease 0.708 0.941 0.00 52 0.921 P06213 R279H Disease 0.482 0.814 0.00 57 0.896 P06213 R762S Disease NA 0.643 0.05 32 0.534 P06213 R926W Disease 0.817 0.877 0.01 43 0.876 P06213 S350L Disease NA 0.595 0.01 35 0.755 P06213 T858A Disease 0.217 0.168 0.62 13 0.137 P06213 T937M Disease 0.833 0.346 0.00 2 0.607 P06213 V167L Disease 0.164 0.282 0.16 20 0.275 P06213 W439S Disease NA 0.908 0.07 38 0.839 P06213 A1055V Disease 0.644 0.883 0.00 40 0.868 P06213 A1075D Disease 0.766 0.940 0.00 47 0.887 P06213 A1161T Disease 0.918 0.901 0.01 43 0.897 P06213 A1162E Disease 0.745 0.870 0.01 55 0.920 P06213 E1206D Disease 0.994 0.872 0.00 64 0.951 P06213 E1206K Disease 0.997 0.939 0.00 70 0.953 P06213 G1035V Disease 0.998 0.882 0.01 70 0.956 P06213 I1023F Polymorphism 0.672 0.635 0.01 43 0.813 P06213 I1143T Disease 0.669 0.710 0.03 38 0.849 P06213 P1205L Disease 0.845 0.918 0.01 33 0.806 P06213 R1020Q Disease 0.680 0.730 0.03 43 0.853 P06213 R1119W Disease 0.938 0.810 0.00 56 0.930 P06213 R1158Q Disease 0.675 0.935 0.00 67 0.943 P06213 R1158W Disease 0.937 0.941 0.00 66 0.937 P06213 R1191Q Disease 0.681 0.640 0.02 28 0.794 P06213 R1201Q Disease 0.681 0.795 0.04 51 0.902 P06213 R1201W Disease 0.939 0.922 0.00 55 0.933 P06213 R1378Q Disease NA 0.136 0.39 33 0.145 P06213 T1282A Polymorphism 0.236 0.282 0.03 15 0.301 P06213 W1220L Disease 0.750 0.901 0.03 59 0.922 P06213 W1227S Disease 0.860 0.941 0.00 52 0.926 P06213 Y1361C Polymorphism NA 0.760 0.01 12 0.553 P06239 G201S Polymorphism 0.060 0.287 0.86 -36 0.109 P06241 D506E Polymorphism 0.258 0.123 0.40 -17 0.179 P06241 I445F Polymorphism 0.559 0.559 0.09 36 0.782 P06276 D98G Disease NA 0.598 0.09 8 0.451 P06276 D98H Disease NA 0.610 0.02 -4 0.459 P06276 F56I Disease 0.877 0.745 0.00 66 0.915 P06276 P65S Disease 0.702 0.820 0.00 54 0.898 P06276 T52M Disease 0.562 0.575 0.07 -23 0.533 P06276 Y61C Disease 0.944 0.891 0.00 59 0.929 P06276 A227V Disease 0.951 0.855 0.00 38 0.912 P06276 A229T Disease 0.699 0.555 0.01 40 0.792 P06276 A356D Disease 0.527 0.717 0.00 29 0.781 P06276 A567T Disease NA 0.191 0.24 18 0.234 P06276 D198E Disease 0.998 0.898 0.00 54 0.941 P06276 E283D Polymorphism 0.271 0.170 0.95 -42 0.128 P06276 E488K Disease 0.884 0.709 0.00 49 0.899 P06276 E525V Disease 0.575 0.159 0.22 4 0.381 P06276 F446S Disease 0.335 0.444 0.31 25 0.380 P06276 F502L Disease 0.998 0.873 0.00 50 0.947 P06276 G143D Disease 0.996 0.913 0.00 73 0.817 P06276 G393R Disease 0.383 0.791 0.24 0 0.629 P06276 G418V Disease 0.424 0.194 0.01 -23 0.246 P06276 K295R Disease 0.220 0.274 0.78 -28 0.230 P06276 L153F Disease 0.840 0.648 0.00 7 0.800 P06276 L335P Disease 0.875 0.846 0.00 51 0.900 P06276 L358I Disease 0.373 0.392 0.12 -37 0.275 P06276 N124Y Disease 0.984 0.859 0.00 57 0.934 P06276 P128S Disease 0.651 0.791 0.01 35 0.748 P06276 Q546L Disease 0.393 0.182 0.37 -12 0.261 P06276 R414C Disease 0.850 0.789 0.01 53 0.897 P06276 R543C Disease 0.866 0.721 0.00 42 0.853 P06276 S226G Disease 0.916 0.700 0.00 13 0.793 P06276 T271M Disease 0.811 0.290 0.00 -1 0.576 P06276 T278P Disease 0.476 0.738 0.02 23 0.761 P06276 V170M Disease 0.856 0.829 0.01 50 0.836 P06276 W499R Disease 0.881 0.930 0.00 71 0.929 P06276 Y156C Disease 0.988 0.907 0.00 61 0.941 P06280 A20P Disease NA 0.427 0.03 3 0.436 P06280 A31V Disease 0.218 0.647 0.37 11 0.379 P06280 A97V Disease 0.263 0.364 0.07 -4 0.317 P06280 C52R Disease 0.599 0.964 0.00 74 0.832 P06280 C52S Disease 0.624 0.927 0.00 45 0.686 P06280 C56F Disease 0.843 0.958 0.00 63 0.911 P06280 C56G Disease 0.705 0.938 0.00 53 0.853 P06280 C56Y Disease 0.554 0.955 0.00 65 0.790 P06280 C94S Disease 0.760 0.863 0.00 49 0.853 P06280 C94Y Disease 0.840 0.903 0.00 59 0.935 P06280 D92H Disease 0.982 0.925 0.00 78 0.949 P06280 D92Y Disease 0.989 0.939 0.00 72 0.952 P06280 D93G Disease 0.919 0.952 0.00 55 0.936 P06280 E59K Disease 0.208 0.201 0.05 30 0.290 P06280 E66Q Disease 0.562 0.905 0.00 45 0.712 P06280 G35R Disease 0.670 0.987 0.00 55 0.882 P06280 G85D Disease 0.981 0.907 0.00 68 0.952 P06280 H46R Disease 0.285 0.592 0.10 51 0.695 P06280 H46Y Disease 0.539 0.768 0.07 44 0.840 P06280 I91T Disease 0.877 0.874 0.01 47 0.874 P06280 L32P Disease 0.791 0.978 0.04 68 0.895 P06280 L89P Disease 0.886 0.848 0.00 31 0.892 P06280 L89R Disease 0.876 0.676 0.00 49 0.884 P06280 M42V Disease 0.890 0.946 0.00 63 0.943 P06280 M72V Disease 0.389 0.649 0.04 5 0.511 P06280 N34S Disease 0.529 0.905 0.04 53 0.748 P06280 P40L Disease 0.982 0.934 0.00 54 0.956 P06280 P40S Disease 0.970 0.927 0.00 58 0.956 P06280 R49L Disease 0.465 0.592 0.31 26 0.550 P06280 R49P Disease 0.664 0.891 0.15 57 0.910 P06280 R49S Disease 0.234 0.454 0.30 20 0.352 P06280 S65T Disease 0.436 0.500 0.15 -13 0.449 P06280 W47G Disease 0.971 0.952 0.00 70 0.951 P06280 W95S Disease 0.958 0.903 0.00 67 0.946 P06280 Y86C Disease 0.985 0.940 0.00 54 0.951 P06280 A143P Disease 0.812 0.911 0.12 41 0.853 P06280 A143T Disease 0.644 0.721 0.11 39 0.800 P06280 A156T Disease 0.783 0.913 0.01 52 0.862 P06280 A156V Disease 0.673 0.879 0.07 41 0.771 P06280 A230T Disease 0.296 0.316 0.12 13 0.218 P06280 A288D Disease 0.927 0.926 0.01 55 0.938 P06280 A377D Disease 0.649 0.334 0.20 14 0.514 P06280 C142R Disease 0.942 0.957 0.00 77 0.945 P06280 C142Y Disease 0.973 0.924 0.00 75 0.943 P06280 C172R Disease 0.930 0.962 0.00 79 0.945 P06280 C172Y Disease 0.701 0.933 0.00 73 0.940 P06280 C202W Disease 0.992 0.960 0.01 72 0.952 P06280 C202Y Disease 0.986 0.943 0.03 68 0.951 P06280 C223G Disease 0.217 0.551 0.57 44 0.388 P06280 C378Y Disease 0.440 0.389 0.09 -4 0.268 P06280 D165V Disease 0.986 0.924 0.00 48 0.932 P06280 D170V Disease 0.986 0.873 0.00 71 0.949 P06280 D231N Disease 0.954 0.929 0.06 75 0.927 P06280 D244H Disease 0.703 0.622 0.02 39 0.801 P06280 D244N Disease 0.521 0.730 1.00 6 0.450 P06280 D264V Disease 0.986 0.915 0.00 71 0.953 P06280 D266H Disease 0.982 0.903 0.00 73 0.947 P06280 D266N Disease 0.954 0.935 0.00 64 0.950 P06280 D266V Disease 0.986 0.897 0.00 69 0.949 P06280 D313Y Disease 0.820 0.697 0.02 32 0.847 P06280 E341K Disease 0.261 0.831 0.86 19 0.382 P06280 E358K Disease 0.312 0.805 0.41 11 0.508 P06280 F113L Disease 0.890 0.886 0.00 55 0.934 P06280 F113S Disease 0.962 0.911 0.00 57 0.949 P06280 G128E Disease 0.948 0.941 0.02 64 0.947 P06280 G138R Disease 0.968 0.961 0.00 63 0.956 P06280 G144V Disease 0.662 0.859 0.01 28 0.791 P06280 G163V Disease 0.844 0.823 0.09 51 0.908 P06280 G183D Disease 0.422 0.765 0.39 29 0.544 P06280 G258R Disease 0.373 0.878 0.14 46 0.680 P06280 G260A Disease 0.788 0.840 0.00 45 0.887 P06280 G261D Disease 0.621 0.787 0.51 48 0.854 P06280 G328A Disease 0.201 0.614 0.88 -12 0.333 P06280 G328R Disease 0.857 0.912 0.01 57 0.936 P06280 G361R Disease 0.226 0.841 0.38 19 0.437 P06280 G373D Disease NA 0.887 0.64 45 0.690 P06280 G373S Disease NA 0.853 0.17 -14 0.605 P06280 I219N Disease 0.742 0.822 0.04 13 0.768 P06280 I242N Disease 0.759 0.777 0.10 22 0.771 P06280 I289F Disease 0.871 0.827 0.06 49 0.875 P06280 L131P Disease 0.916 0.920 0.01 29 0.892 P06280 L166V Disease 0.591 0.433 0.05 24 0.569 P06280 M187V Disease 0.389 0.878 0.03 60 0.791 P06280 M267I Disease 0.880 0.870 0.49 39 0.862 P06280 M284T Disease 0.846 0.844 0.01 49 0.907 P06280 M296I Disease 0.281 0.541 1.00 -3 0.331 P06280 M296V Disease 0.471 0.822 0.33 16 0.530 P06280 N215S Disease 0.429 0.423 0.71 12 0.346 P06280 N224D Disease 0.727 0.787 0.03 50 0.777 P06280 N224S Disease 0.687 0.753 0.03 60 0.780 P06280 N263S Disease 0.845 0.802 0.00 51 0.842 P06280 N272K Disease 0.487 0.841 0.37 56 0.747 P06280 N272S Disease 0.582 0.738 0.46 49 0.646 P06280 N298H Disease 0.719 0.533 0.04 39 0.772 P06280 N298K Disease 0.542 0.651 0.13 51 0.761 P06280 N298S Disease 0.481 0.448 0.75 11 0.348 P06280 N320K Disease 0.895 0.796 0.00 60 0.926 P06280 N320Y Disease 0.971 0.778 0.00 56 0.938 P06280 P146S Disease 0.702 0.789 0.04 54 0.788 P06280 P205T Disease 0.694 0.734 0.21 51 0.884 P06280 P259L Disease 0.686 0.813 0.39 22 0.820 P06280 P259R Disease 0.683 0.871 0.04 38 0.839 P06280 P265R Disease 0.858 0.829 0.06 64 0.926 P06280 P409A Disease 0.232 0.786 0.10 14 0.469 P06280 P409T Disease 0.456 0.737 0.09 42 0.789 P06280 Q279E Disease 0.385 0.335 1.00 4 0.308 P06280 Q279H Disease 0.749 0.686 0.00 48 0.825 P06280 Q280H Disease 0.655 0.414 0.13 19 0.607 P06280 Q321E Disease 0.844 0.846 0.00 67 0.933 P06280 Q327K Disease 0.384 0.842 0.58 22 0.666 P06280 R100K Disease 0.664 0.799 0.00 51 0.889 P06280 R100T Disease 0.870 0.873 0.00 57 0.896 P06280 R112C Disease 0.972 0.839 0.00 55 0.933 P06280 R112H Disease 0.884 0.705 0.03 43 0.849 P06280 R227Q Disease 0.965 0.875 0.03 79 0.941 P06280 R301Q Disease 0.625 0.786 0.60 39 0.700 P06280 R342Q Disease 0.563 0.843 0.35 51 0.885 P06280 R356W Disease 0.902 0.973 0.03 45 0.852 P06280 R363H Disease 0.637 0.563 0.50 1 0.539 P06280 S148N Disease 0.784 0.888 0.01 43 0.790 P06280 S148R Disease 0.774 0.931 0.00 67 0.941 P06280 S235C Disease 0.902 0.635 0.02 46 0.844 P06280 S297F Disease 0.948 0.821 0.01 56 0.935 P06280 T410A Disease 0.292 0.255 0.27 18 0.314 P06280 V269A Disease 0.503 0.457 0.17 15 0.585 P06280 V316E Disease 0.921 0.778 0.00 54 0.921 P06280 W162C Disease 0.984 0.905 0.09 70 0.944 P06280 W162R Disease 0.958 0.923 0.24 69 0.947 P06280 W226R Disease 0.971 0.914 0.00 75 0.950 P06280 W236C Disease 0.980 0.831 0.00 75 0.945 P06280 W236L Disease 0.793 0.752 0.03 70 0.867 P06280 W287C Disease 0.992 0.928 0.00 67 0.955 P06280 W287G Disease 0.975 0.936 0.00 62 0.955 P06280 W340R Disease 0.702 0.955 0.00 72 0.940 P06280 Y134S Disease 0.958 0.929 0.00 60 0.951 P06280 Y216D Disease 0.689 0.856 0.04 67 0.865 P06307 G32E Polymorphism 0.139 0.072 0.59 -44 0.056 P06340 R105C Polymorphism 0.645 0.619 0.08 -7 0.698 P06396 A129T Polymorphism 0.817 0.962 0.02 42 0.870 P06396 D214N Disease 0.951 0.939 0.00 43 0.941 P06396 D214Y Disease 0.988 0.926 0.00 61 0.964 P06400 E72Q Disease 0.229 0.096 0.55 9 0.150 P06400 A525G Polymorphism 0.477 0.789 0.12 42 0.806 P06400 A635P Disease 0.140 0.478 0.31 -3 0.217 P06400 C706Y Disease 0.348 0.971 0.00 53 0.878 P06400 C712R Disease 0.392 0.681 0.06 67 0.848 P06400 D697E Polymorphism 0.794 0.492 0.06 31 0.717 P06400 E137D Disease 0.208 0.120 0.14 -1 0.209 P06400 E746G Polymorphism 0.291 0.153 0.82 31 0.129 P06400 G310E Disease 0.162 0.245 0.39 25 0.271 P06400 H549Y Disease 0.397 0.961 0.00 44 0.688 P06400 H673P Disease 0.366 0.607 0.21 31 0.463 P06400 I185T Disease 0.330 0.170 0.79 30 0.265 P06400 K447Q Disease 0.121 0.269 0.44 -30 0.188 P06400 K530R Disease 0.181 0.752 0.00 30 0.445 P06400 K616E Disease 0.097 0.224 0.80 12 0.183 P06400 L569F Polymorphism 0.379 0.721 0.03 31 0.596 P06400 L657P Disease 0.725 0.989 0.00 62 0.921 P06400 L662P Disease 0.715 0.976 0.01 50 0.899 P06400 M457R Disease 0.241 0.545 0.00 45 0.718 P06400 N133H Polymorphism 0.184 0.105 0.10 0 0.096 P06400 N803K Disease 0.183 0.806 0.02 63 0.880 P06400 Q436K Polymorphism 0.155 0.126 0.96 23 0.185 P06400 Q685P Disease 0.420 0.846 0.02 48 0.847 P06400 R358G Disease 0.263 0.359 0.53 33 0.313 P06400 R358Q Disease 0.190 0.177 0.56 15 0.214 P06400 R500G Disease 0.208 0.220 0.24 20 0.256 P06400 R661W Disease 0.738 0.945 0.00 62 0.938 P06400 S567L Disease 0.162 0.952 0.00 49 0.826 P06400 V654E Disease 0.294 0.704 0.00 47 0.755 P06401 A50T Polymorphism NA 0.113 0.06 -8 0.115 P06401 A120V Polymorphism NA 0.111 0.16 10 0.100 P06401 A444S Polymorphism NA 0.153 0.87 25 0.096 P06401 R625I Polymorphism 0.771 0.608 0.00 66 0.909 P06401 S344T Polymorphism NA 0.130 0.41 -40 0.110 P06576 E274Q Polymorphism 0.740 0.881 0.00 53 0.810 P06681 E318D Polymorphism NA 0.200 0.50 -9 0.170 P06681 F533L Polymorphism 0.314 0.201 1.00 -15 0.180 P06702 H20R Polymorphism 0.767 0.911 0.02 27 0.851 P06703 G90D Polymorphism 0.036 0.537 0.01 30 0.659 P06703 N69S Polymorphism 0.358 0.187 0.01 -15 0.198 P06727 Q77H Polymorphism 0.200 0.508 0.35 30 0.338 P06727 R279K Polymorphism 0.137 0.049 1.00 -33 0.060 P06727 V307L Polymorphism 0.151 0.196 0.08 25 0.192 P06729 H266Q Polymorphism 0.148 0.086 0.58 -5 0.047 P06729 H339N Polymorphism 0.295 0.072 0.46 20 0.052 P06731 A340D Polymorphism 0.195 0.324 0.52 54 0.413 P06731 Q137P Polymorphism 0.680 0.738 0.10 9 0.700 P06733 P325Q Polymorphism NA 0.707 0.01 25 0.798 P06734 R284Q Polymorphism 0.089 0.655 0.08 23 0.133 P06737 I806L Polymorphism 0.345 0.823 0.21 1 0.654 P06737 N339S Disease 0.876 0.847 0.00 58 0.913 P06737 N377K Disease 0.688 0.925 0.01 57 0.921 P06737 R425P Polymorphism 0.648 0.907 0.10 50 0.902 P06737 R715S Polymorphism 0.295 0.640 0.14 -11 0.330 P06737 V231E Polymorphism 0.949 0.906 0.00 63 0.940 P06737 V698G Polymorphism 0.802 0.848 0.00 22 0.865 P06744 T5I Disease 0.511 0.930 0.02 6 0.633 P06744 H20P Disease 0.265 0.806 0.20 49 0.821 P06744 R75G Disease 0.469 0.516 0.08 5 0.562 P06744 R83W Disease 0.827 0.695 0.00 9 0.839 P06744 A300P Disease 0.905 0.939 0.03 53 0.915 P06744 D539N Disease 0.245 0.882 0.01 53 0.608 P06744 E495K Disease 0.806 0.966 0.00 68 0.938 P06744 G159S Disease 0.958 0.949 0.00 60 0.946 P06744 H389R Disease 0.968 0.937 0.00 72 0.928 P06744 I208T Polymorphism 0.762 0.753 0.00 32 0.848 P06744 I525T Disease 0.723 0.729 0.00 20 0.818 P06744 L339P Disease 0.870 0.956 0.00 33 0.875 P06744 L487F Disease 0.522 0.968 0.01 38 0.493 P06744 L517V Disease 0.623 0.890 0.00 20 0.842 P06744 Q343R Disease 0.551 0.860 0.00 32 0.856 P06744 R273H Disease 0.973 0.924 0.00 71 0.932 P06744 R347C Disease 0.895 0.933 0.01 35 0.881 P06744 R347H Disease 0.726 0.827 0.06 13 0.606 P06744 R472H Disease 0.677 0.877 0.05 41 0.621 P06744 S278L Disease 0.929 0.961 0.00 43 0.881 P06744 T195I Disease 0.457 0.713 0.19 -25 0.468 P06744 T224M Disease 0.646 0.431 0.00 6 0.639 P06744 T375R Disease 0.611 0.893 0.00 58 0.905 P06744 V101M Disease 0.582 0.321 0.00 -21 0.585 P06753 M8R Disease 0.616 0.906 0.00 37 0.842 P06756 S548A Polymorphism 0.107 0.237 0.11 -20 0.231 P06858 H71Q Polymorphism 0.291 0.599 0.27 -25 0.319 P06858 N70S Disease 0.791 0.725 0.02 21 0.792 P06858 V96L Disease 0.448 0.840 0.10 -25 0.503 P06858 D183H Disease 0.998 0.924 0.00 76 0.943 P06858 E448K Disease 0.311 0.400 0.11 30 0.435 P06858 F297L Disease 0.716 0.802 0.00 18 0.784 P06858 G181V Disease 0.935 0.919 0.00 48 0.862 P06858 G186E Disease 0.922 0.885 0.86 18 0.832 P06858 G222E Disease 0.987 0.909 0.00 72 0.946 P06858 L303F Disease 0.769 0.454 0.63 -14 0.589 P06858 L392V Disease 0.672 0.353 0.06 31 0.528 P06858 N318S Disease 0.426 0.442 0.23 -20 0.308 P06858 P234L Disease 0.935 0.910 0.00 42 0.873 P06858 R102S Disease 0.750 0.745 0.15 4 0.716 P06858 S199C Disease 0.901 0.781 0.02 0 0.789 P06858 V370M Polymorphism 0.290 0.127 0.10 17 0.283 P06858 Y289H Disease 0.476 0.750 0.00 45 0.651 P06865 L39R Disease NA 0.694 0.01 -6 0.556 P06865 P25S Disease NA 0.699 0.00 -4 0.667 P06865 C458Y Disease 0.910 0.924 0.01 57 0.938 P06865 D258H Disease 0.978 0.929 0.00 72 0.932 P06865 D314V Disease 0.556 0.820 0.00 49 0.885 P06865 E482K Disease 0.942 0.950 0.00 72 0.936 P06865 F211S Disease 0.973 0.758 0.00 56 0.930 P06865 G250D Disease 0.841 0.892 0.00 50 0.918 P06865 G250S Disease 0.799 0.792 0.00 36 0.802 P06865 G269D Disease 0.681 0.748 0.00 40 0.809 P06865 G269S Disease 0.475 0.632 0.00 -26 0.478 P06865 G454S Disease 0.980 0.934 0.00 72 0.943 P06865 G455R Disease 0.906 0.948 0.00 69 0.935 P06865 H204R Disease 0.983 0.924 0.00 64 0.931 P06865 I335F Disease 0.924 0.841 0.00 39 0.862 P06865 K197T Disease 0.962 0.897 0.00 58 0.925 P06865 L127F Disease 0.882 0.876 0.03 42 0.870 P06865 L127R Disease 0.507 0.877 0.00 62 0.875 P06865 L484Q Disease 0.674 0.822 0.00 34 0.755 P06865 M301R Disease 0.659 0.831 0.05 39 0.860 P06865 N196S Disease 0.482 0.452 0.13 4 0.370 P06865 N295S Disease 0.822 0.446 0.45 -4 0.657 P06865 N399D Polymorphism 0.284 0.412 0.60 3 0.334 P06865 R166G Disease 0.905 0.913 0.01 50 0.920 P06865 R170Q Disease 0.993 0.908 0.00 73 0.940 P06865 R170W Disease 0.998 0.914 0.00 73 0.943 P06865 R178C Disease 0.997 0.854 0.00 74 0.942 P06865 R178H Disease 0.995 0.887 0.00 70 0.939 P06865 R178L Disease 0.994 0.889 0.00 69 0.939 P06865 R252H Disease 0.719 0.881 0.00 22 0.808 P06865 R252L Disease 0.569 0.922 0.00 34 0.763 P06865 R499C Disease 0.987 0.899 0.00 69 0.955 P06865 R499H Disease 0.951 0.848 0.00 62 0.945 P06865 R504C Disease 0.951 0.900 0.01 44 0.921 P06865 R504H Disease 0.879 0.762 0.01 37 0.865 P06865 S210F Disease 0.935 0.905 0.00 50 0.925 P06865 S226F Disease 0.906 0.946 0.01 37 0.889 P06865 S279P Disease 0.333 0.765 0.28 -5 0.408 P06865 S293I Polymorphism 0.493 0.671 0.40 -13 0.357 P06865 V192L Disease 0.499 0.694 0.26 -3 0.339 P06865 V200M Disease 0.884 0.685 0.02 46 0.826 P06865 V391M Disease 0.800 0.478 0.01 11 0.714 P06865 W420C Disease 0.900 0.827 0.00 64 0.876 P06865 W474C Disease 0.966 0.909 0.00 66 0.939 P06865 W485R Disease 0.992 0.958 0.00 73 0.945 P06865 Y180H Disease 0.786 0.829 0.00 57 0.919 P06870 R77H Polymorphism 0.619 0.268 0.13 -9 0.513 P06870 V193E Polymorphism 0.585 0.661 0.04 64 0.795 P07093 I51M Polymorphism NA 0.418 0.10 3 0.420 P07098 P348T Polymorphism 0.552 0.336 0.32 -10 0.578 P07099 E44Q Polymorphism 0.271 0.388 0.45 -12 0.271 P07099 R49C Polymorphism 0.470 0.849 0.00 43 0.850 P07099 H139R Polymorphism 0.236 0.288 0.63 -7 0.178 P07099 L452Q Polymorphism NA 0.791 0.05 49 0.863 P07099 R454Q Polymorphism NA 0.233 0.60 -17 0.211 P07099 T396I Polymorphism 0.310 0.767 0.12 44 0.658 P07099 T408M Polymorphism 0.238 0.476 0.16 7 0.311 P07099 Y113H Polymorphism 0.580 0.465 0.00 45 0.640 P07101 L236P Disease 0.692 0.778 0.18 0 0.797 P07101 Q412K Disease 0.607 0.780 0.04 30 0.645 P07101 R233H Disease 0.940 0.982 0.00 56 0.952 P07101 R337H Disease 0.912 0.911 0.00 41 0.906 P07101 T276P Disease 0.733 0.866 0.05 28 0.833 P07101 T314M Disease 0.958 0.814 0.00 52 0.934 P07101 T494M Disease 0.913 0.876 0.00 42 0.893 P07101 V499M Polymorphism 0.606 0.691 0.11 10 0.593 P07108 D39N Polymorphism 0.710 0.883 0.31 24 0.803 P07108 G86R Polymorphism 0.512 0.727 0.00 35 0.787 P07195 M175V Polymorphism 0.396 0.495 0.04 1 0.469 P07196 P8L Disease 0.311 0.317 0.04 20 0.399 P07196 P8Q Disease 0.303 0.475 0.06 9 0.437 P07196 P8R Disease 0.303 0.413 0.05 22 0.465 P07196 E90K Disease 0.994 0.856 0.00 52 0.937 P07196 N98S Disease 0.935 0.846 0.00 34 0.886 P07196 P22S Disease 0.191 0.705 1.00 24 0.425 P07196 D468N Polymorphism 0.212 0.118 0.40 25 0.113 P07196 E396K Disease 0.956 0.871 0.00 44 0.878 P07196 L336P Disease 0.728 0.856 0.00 40 0.859 P07196 Q332P Disease 0.844 0.891 0.00 45 0.895 P07202 A53P Disease NA 0.909 0.02 21 0.734 P07202 A326T Disease 0.408 0.801 0.02 42 0.787 P07202 A373S Polymorphism 0.212 0.313 0.89 -57 0.167 P07202 C808R Disease 0.735 0.541 0.00 76 0.916 P07202 D240N Disease 0.945 0.972 0.01 52 0.921 P07202 D796Y Disease 0.789 0.356 0.01 61 0.769 P07202 E378K Disease 0.173 0.738 0.68 18 0.266 P07202 E799K Disease 0.434 0.306 0.02 57 0.600 P07202 G493S Disease 0.540 0.776 0.03 46 0.696 P07202 G533C Disease 0.980 0.876 0.00 25 0.892 P07202 G590S Disease 0.308 0.397 0.59 16 0.342 P07202 G771R Disease 0.735 0.464 0.04 50 0.678 P07202 I447F Disease 0.508 0.596 0.17 -13 0.452 P07202 L458P Disease 0.778 0.963 0.00 61 0.938 P07202 L793P Polymorphism 0.624 0.197 0.11 19 0.424 P07202 M706V Polymorphism 0.123 0.603 0.30 1 0.083 P07202 N307T Disease NA 0.214 0.34 -48 0.258 P07202 P499L Disease 0.690 0.648 0.02 23 0.797 P07202 Q660E Disease 0.992 0.922 0.02 60 0.953 P07202 R491H Disease 0.979 0.918 0.00 73 0.949 P07202 R648Q Disease 0.870 0.453 0.31 10 0.624 P07202 R665W Disease 0.992 0.949 0.00 60 0.955 P07202 R693W Disease 0.977 0.919 0.00 36 0.924 P07202 T725P Polymorphism 0.300 0.354 1.00 -60 0.148 P07202 V433M Disease 0.375 0.741 0.07 34 0.737 P07202 V618M Polymorphism 0.088 0.616 0.20 -29 0.071 P07202 V839I Disease 0.079 0.095 0.44 -25 0.059 P07202 W527C Disease 0.976 0.750 0.22 44 0.803 P07202 Y453D Disease 0.720 0.617 0.00 53 0.836 P07204 A162P Polymorphism NA 0.176 0.12 -26 0.250 P07204 A473V Polymorphism NA 0.432 0.56 22 0.297 P07204 D486Y Disease 0.165 0.385 0.05 45 0.428 P07225 A68D Disease 0.844 0.791 0.00 60 0.883 P07225 C88Y Disease NA 0.983 0.05 52 0.883 P07225 E67A Disease 0.774 0.825 0.00 29 0.825 P07225 F72C Disease 0.937 0.949 0.00 57 0.956 P07225 G52D Disease 0.885 0.821 0.01 34 0.804 P07225 G95E Disease NA 0.731 0.20 28 0.553 P07225 G95R Disease NA 0.719 0.20 31 0.583 P07225 K50E Disease 0.215 0.753 0.14 36 0.635 P07225 L15H Disease 0.410 0.212 0.05 13 0.364 P07225 P76L Polymorphism 0.905 0.239 0.05 -11 0.527 P07225 R40L Disease 0.812 0.693 0.01 -1 0.790 P07225 R41H Disease 0.874 0.853 0.00 -51 0.822 P07225 R90C Disease NA 0.768 0.05 45 0.804 P07225 R90H Disease NA 0.347 0.22 -25 0.398 P07225 T78M Disease 0.901 0.863 0.00 50 0.925 P07225 T98S Polymorphism NA 0.418 0.79 -28 0.235 P07225 V18E Disease 0.250 0.408 0.04 41 0.521 P07225 V87L Disease NA 0.308 0.11 6 0.256 P07225 A525P Disease 0.586 0.376 0.21 47 0.548 P07225 A616P Disease 0.515 0.244 0.94 32 0.470 P07225 C121Y Disease 0.938 0.937 0.00 61 0.945 P07225 C161G Disease 0.688 0.861 0.06 32 0.839 P07225 C175F Disease 0.870 0.882 0.00 73 0.972 P07225 C186Y Disease 0.999 0.879 0.00 69 0.993 P07225 C241S Disease 0.691 0.868 0.05 55 0.987 P07225 C247G Disease 0.440 0.831 0.00 56 0.982 P07225 C265R Disease 0.524 0.861 0.00 29 0.864 P07225 C265W Disease 0.791 0.821 0.00 50 0.964 P07225 C267S Disease 0.307 0.857 0.00 58 0.972 P07225 C449S Disease 0.821 0.906 0.00 60 0.938 P07225 C475R Disease 0.923 0.915 0.00 77 0.949 P07225 C568Y Disease 0.773 0.865 0.02 64 0.926 P07225 C639F Disease 0.931 0.877 0.00 64 0.953 P07225 C639Y Disease 0.944 0.896 0.00 66 0.954 P07225 C666R Disease 0.907 0.741 0.00 71 0.938 P07225 D129G Disease 0.470 0.365 0.91 31 0.373 P07225 D157G Disease 0.786 0.613 0.08 31 0.672 P07225 D243N Disease 0.401 0.584 0.30 44 0.622 P07225 D245G Disease 0.478 0.642 0.08 56 0.893 P07225 D376N Disease 0.061 0.182 0.47 11 0.122 P07225 E204G Disease 0.780 0.545 0.10 45 0.853 P07225 E249K Disease 0.378 0.376 0.78 57 0.490 P07225 E390K Disease 0.702 0.262 0.29 52 0.451 P07225 G336D Disease NA 0.910 0.00 48 0.872 P07225 G336S Disease NA 0.929 0.02 41 0.808 P07225 G336V Disease NA 0.806 0.01 45 0.830 P07225 G357R Disease NA 0.803 0.00 71 0.883 P07225 G381D Disease 0.855 0.804 0.00 65 0.930 P07225 G381V Disease 0.881 0.692 0.00 52 0.907 P07225 G482C Disease 0.810 0.892 0.00 59 0.933 P07225 G521D Disease 0.635 0.725 0.02 69 0.897 P07225 G638D Disease 0.896 0.620 0.01 70 0.933 P07225 H664P Disease 0.891 0.452 0.04 54 0.696 P07225 I562L Disease 0.069 0.050 0.35 -1 0.064 P07225 I644S Disease 0.574 0.668 0.10 52 0.782 P07225 K196E Disease 0.362 0.327 1.00 56 0.289 P07225 K364E Disease 0.473 0.364 1.00 57 0.483 P07225 L300P Disease NA 0.836 0.26 -7 0.694 P07225 L339P Disease NA 0.662 0.01 42 0.626 P07225 L351P Disease NA 0.702 0.15 48 0.712 P07225 L446P Disease 0.923 0.845 0.01 47 0.907 P07225 L526S Disease 0.625 0.656 0.10 51 0.827 P07225 L552S Disease 0.395 0.426 0.01 40 0.596 P07225 L575R Disease 0.681 0.332 0.01 64 0.830 P07225 L584Q Disease 0.713 0.372 0.01 49 0.620 P07225 L622R Disease 0.630 0.564 0.02 63 0.907 P07225 M385V Polymorphism 0.272 0.130 0.29 1 0.098 P07225 M611K Disease 0.537 0.371 0.89 65 0.764 P07225 M611T Disease 0.481 0.246 0.69 54 0.354 P07225 M640T Disease 0.811 0.768 0.01 51 0.894 P07225 N166Y Disease NA 0.245 0.87 51 0.424 P07225 N258S Disease 0.369 0.823 0.53 40 0.644 P07225 N583H Polymorphism 0.382 0.116 0.21 39 0.261 P07225 P667L Disease 0.500 0.744 0.00 44 0.691 P07225 R101C Disease NA 0.792 0.16 18 0.574 P07225 R111S Disease 0.472 0.658 0.56 45 0.556 P07225 R233K Disease 0.097 0.253 0.97 4 0.167 P07225 R355H Disease NA 0.500 0.44 52 0.580 P07225 R515C Disease 0.822 0.521 0.00 71 0.804 P07225 R515P Disease 0.677 0.539 0.00 63 0.808 P07225 R561G Disease 0.405 0.213 0.37 51 0.353 P07225 S324P Disease NA 0.742 0.20 40 0.655 P07225 S501A Disease 0.162 0.094 0.89 43 0.169 P07225 S665L Disease 0.810 0.570 0.04 41 0.826 P07225 T144N Disease 0.261 0.220 0.49 1 0.187 P07225 T532A Disease 0.286 0.085 0.76 41 0.102 P07225 T630I Disease 0.354 0.255 0.35 51 0.396 P07225 V508G Disease 0.588 0.195 0.01 28 0.455 P07225 V508M Disease 0.180 0.117 0.26 -35 0.168 P07225 W149C Disease 0.956 0.302 0.00 42 0.717 P07225 W383R Disease 0.892 0.767 0.00 68 0.932 P07225 Y266C Disease 0.796 0.320 0.13 26 0.578 P07225 Y485C Disease 0.821 0.590 0.00 61 0.920 P07225 Y636C Disease 0.684 0.625 0.00 63 0.904 P07288 E32K Polymorphism 0.370 0.140 0.36 -19 0.196 P07288 I179T Polymorphism 0.273 0.156 0.03 45 0.366 P07315 F6L Polymorphism NA 0.598 0.28 -14 0.419 P07315 T5P Disease NA 0.830 0.06 29 0.823 P07316 R90T Polymorphism 0.805 0.346 0.00 42 0.631 P07316 S73I Polymorphism 0.797 0.277 0.00 48 0.633 P07320 P24S Disease 0.210 0.273 0.78 -20 0.239 P07320 P24T Disease 0.345 0.387 0.30 7 0.356 P07320 R15C Disease 0.962 0.779 0.00 42 0.891 P07320 R59H Disease 0.600 0.281 0.05 26 0.591 P07320 E107A Disease 0.704 0.436 0.00 46 0.629 P07320 M102V Polymorphism 0.327 0.425 0.80 19 0.410 P07332 R85C Polymorphism NA 0.300 0.00 39 0.526 P07332 M323V Polymorphism NA 0.117 0.26 -19 0.119 P07333 V32G Polymorphism 0.502 0.743 0.00 3 0.693 P07333 E920D Polymorphism 0.054 0.366 0.69 -13 0.203 P07333 G413S Polymorphism 0.067 0.318 0.44 -19 0.225 P07333 H362R Polymorphism NA 0.357 0.05 18 0.436 P07333 L536V Polymorphism 0.174 0.193 0.03 -46 0.252 P07333 R921Q Polymorphism 0.059 0.097 0.74 -9 0.054 P07333 V279M Polymorphism 0.190 0.124 0.23 5 0.212 P07333 Y969C Polymorphism NA 0.646 0.00 48 0.738 P07339 A58V Polymorphism 0.055 0.072 0.50 -49 0.123 P07339 F229I Disease 0.931 0.816 0.00 49 0.862 P07339 W383C Disease 0.985 0.946 0.00 62 0.950 P07355 V98L Polymorphism 0.142 0.671 0.80 -23 0.141 P07357 Q93K Polymorphism 0.132 0.192 0.21 -5 0.192 P07357 E561Q Polymorphism 0.139 0.295 0.77 -17 0.202 P07357 P575L Polymorphism 0.245 0.039 0.23 -29 0.077 P07357 R485L Polymorphism 0.501 0.752 0.03 33 0.695 P07358 P261L Polymorphism 0.024 0.233 0.04 41 0.314 P07358 R117G Polymorphism NA 0.627 0.37 34 0.635 P07359 C81R Disease 0.321 0.691 0.09 50 0.820 P07359 L73F Disease 0.493 0.771 0.00 62 0.710 P07359 L86F Polymorphism 0.402 0.475 0.02 46 0.514 P07359 R72H Polymorphism 0.136 0.414 0.59 -14 0.174 P07359 A172V Disease 0.413 0.225 0.15 31 0.414 P07359 C225S Disease 0.999 0.788 0.00 59 0.938 P07359 L145P Disease 0.739 0.840 0.00 62 0.882 P07360 R69Q Polymorphism 0.372 0.210 0.58 46 0.228 P07384 G492R Polymorphism 0.865 0.834 0.00 60 0.934 P07384 R433P Polymorphism 0.393 0.784 0.03 16 0.676 P07384 T103A Polymorphism 0.558 0.425 0.02 2 0.594 P07384 V676I Polymorphism 0.207 0.193 0.67 -22 0.230 P07451 V31I Polymorphism NA 0.219 1.00 -40 0.190 P07476 E227Q Polymorphism 0.369 0.179 0.21 24 0.151 P07476 K174E Polymorphism 0.151 0.049 1.00 -19 0.031 P07476 P236S Polymorphism 0.141 0.078 0.82 28 0.057 P07476 Q237E Polymorphism 0.149 0.042 1.00 -13 0.011 P07476 Q312K Polymorphism 0.193 0.149 0.80 26 0.132 P07476 T113A Polymorphism 0.215 0.047 0.81 -41 0.018 P07476 V480L Polymorphism NA 0.038 1.00 -47 0.007 P07477 A16V Disease 0.073 0.662 0.51 -62 0.132 P07477 D22G Disease 0.478 0.349 0.59 -27 0.266 P07477 E79K Disease 0.106 0.278 0.92 -21 0.147 P07477 K23R Disease 0.215 0.072 0.83 -61 0.140 P07477 N29I Disease 0.138 0.281 0.07 20 0.205 P07477 N29T Disease 0.302 0.150 0.55 -24 0.117 P07477 N54S Disease 0.134 0.254 1.00 2 0.212 P07477 C139F Disease 0.855 0.902 0.00 55 0.924 P07477 L104P Disease 0.830 0.709 0.23 20 0.765 P07477 R116C Disease 0.293 0.354 0.00 29 0.435 P07477 R122C Disease 0.701 0.237 0.08 42 0.604 P07477 R122H Disease 0.364 0.171 0.22 -1 0.192 P07478 A117V Polymorphism 0.173 0.150 1.00 -1 0.122 P07498 Y75C Polymorphism 0.851 0.553 0.01 50 0.907 P07498 A145T Polymorphism 0.120 0.064 0.61 -40 0.012 P07498 R110L Polymorphism 0.275 0.282 0.02 22 0.370 P07510 R239C Disease 0.998 0.871 0.00 73 0.936 P07510 V107G Disease 0.737 0.507 0.00 52 0.878 P07550 V34M Polymorphism 0.451 0.462 0.08 16 0.453 P07550 S220C Polymorphism 0.641 0.087 0.10 -33 0.186 P07550 T164I Polymorphism 0.114 0.068 0.83 -51 0.060 P07585 E273Q Polymorphism 0.793 0.426 0.00 -13 0.605 P07602 C241S Disease 0.936 0.969 0.00 40 0.905 P07602 C388F Disease 0.987 0.934 0.00 43 0.940 P07602 L349P Disease 0.952 0.871 0.08 41 0.895 P07602 N215H Disease 0.878 0.708 0.09 47 0.816 P07602 N215K Disease 0.412 0.837 0.13 33 0.636 P07602 T217I Disease 0.885 0.604 0.01 27 0.823 P07686 S62L Disease NA 0.304 0.34 -29 0.377 P07686 A543T Disease 0.598 0.701 0.12 -2 0.580 P07686 C309Y Disease 0.807 0.873 0.01 13 0.746 P07686 C534Y Disease 0.728 0.724 0.00 0 0.782 P07686 K121R Polymorphism NA 0.104 0.49 -61 0.142 P07686 P417L Disease 0.691 0.895 0.01 0 0.830 P07686 P504S Disease 0.841 0.864 0.00 54 0.929 P07686 R505Q Disease 0.752 0.901 0.03 65 0.928 P07686 S255R Disease 0.635 0.848 0.13 28 0.848 P07686 Y456S Disease 0.398 0.847 0.15 16 0.525 P07741 D65V Disease NA 0.890 0.00 51 0.666 P07741 C153R Disease NA 0.810 0.00 46 0.811 P07741 L110P Disease NA 0.846 0.00 35 0.812 P07741 M136T Disease NA 0.819 0.02 12 0.400 P07741 Q121R Polymorphism NA 0.822 0.00 27 0.612 P07741 V150F Disease NA 0.779 0.00 43 0.817 P07814 A296P Polymorphism 0.081 0.396 1.00 12 0.243 P07814 P893H Polymorphism NA 0.076 0.00 30 0.224 P07814 I1043V Polymorphism NA 0.128 1.00 -28 0.082 P07814 T1399N Polymorphism NA 0.620 0.30 -65 0.436 P07858 P91L Polymorphism 0.833 0.359 0.01 28 0.642 P07858 S53G Polymorphism 0.311 0.234 0.40 -27 0.252 P07864 E285Q Polymorphism 0.412 0.409 0.04 -21 0.349 P07902 A81T Disease 0.336 0.563 0.48 -9 0.408 P07902 D28Y Disease 0.511 0.890 0.01 47 0.875 P07902 D98N Disease 0.526 0.873 0.72 45 0.841 P07902 G55C Disease 0.905 0.886 0.04 42 0.910 P07902 I32N Disease 0.659 0.902 0.05 10 0.874 P07902 L74P Disease 0.962 0.972 0.01 43 0.920 P07902 N97S Disease 0.776 0.896 0.00 62 0.918 P07902 Q38P Disease 0.552 0.912 0.28 -16 0.842 P07902 R51L Disease 0.965 0.880 0.00 64 0.951 P07902 R51Q Disease 0.947 0.897 0.00 70 0.946 P07902 R67C Disease 0.796 0.453 0.05 -4 0.638 P07902 S45L Disease 0.897 0.809 0.01 44 0.883 P07902 V44L Disease 0.574 0.770 0.08 27 0.613 P07902 V44M Disease 0.802 0.829 0.02 8 0.772 P07902 A199T Disease 0.253 0.274 0.33 -27 0.218 P07902 A320T Disease 0.449 0.719 0.09 26 0.777 P07902 A330V Disease 0.779 0.924 0.03 14 0.854 P07902 C130Y Disease 0.776 0.941 0.00 39 0.884 P07902 D113N Disease 0.282 0.470 0.14 -6 0.332 P07902 E203K Disease 0.243 0.681 0.38 4 0.553 P07902 E291K Disease 0.372 0.781 0.12 -15 0.553 P07902 E308K Disease 0.328 0.895 0.79 5 0.523 P07902 F117S Disease 0.347 0.738 0.01 22 0.624 P07902 F171S Disease 0.962 0.937 0.00 54 0.956 P07902 F194L Disease 0.362 0.677 0.33 34 0.552 P07902 F294Y Disease 0.715 0.953 0.08 52 0.785 P07902 G179D Disease 0.971 0.927 0.00 78 0.952 P07902 H114L Disease 0.362 0.323 0.10 32 0.408 P07902 H132Y Disease 0.748 0.834 0.07 47 0.861 P07902 H184Q Disease 0.973 0.887 0.00 73 0.951 P07902 H319Q Disease 0.934 0.954 0.16 65 0.946 P07902 I198M Disease 0.423 0.403 0.20 -31 0.403 P07902 I198T Disease 0.208 0.354 0.76 -24 0.154 P07902 K127E Disease 0.242 0.341 0.99 -12 0.154 P07902 K229N Disease 0.585 0.663 0.39 10 0.495 P07902 K285N Disease 0.751 0.815 0.01 27 0.857 P07902 K334R Disease 0.394 0.948 0.09 47 0.836 P07902 L139P Disease 0.970 0.962 0.00 43 0.959 P07902 L195P Disease 0.862 0.943 0.01 40 0.897 P07902 L217P Disease 0.299 0.947 0.10 40 0.604 P07902 L226P Disease 0.646 0.810 0.15 11 0.767 P07902 L282V Disease 0.244 0.365 0.35 -29 0.287 P07902 L289R Disease 0.799 0.904 0.01 35 0.869 P07902 M129T Disease 0.643 0.653 0.02 26 0.777 P07902 M142K Disease 0.939 0.879 0.00 58 0.936 P07902 M142V Disease 0.645 0.875 0.04 43 0.839 P07902 M336L Disease 0.176 0.699 1.00 0 0.252 P07902 P183T Disease 0.466 0.786 0.31 5 0.540 P07902 P324S Disease 0.629 0.963 0.00 28 0.638 P07902 P325L Disease 0.642 0.928 0.00 19 0.861 P07902 Q118H Disease 0.530 0.308 0.03 -11 0.532 P07902 Q188R Disease 0.929 0.930 0.00 70 0.950 P07902 Q212H Disease 0.440 0.293 0.06 8 0.386 P07902 Q252H Disease 0.574 0.789 0.00 35 0.588 P07902 Q317H Disease 0.204 0.709 0.45 8 0.361 P07902 Q317R Disease 0.331 0.868 0.53 12 0.528 P07902 Q344K Disease 0.355 0.594 0.45 11 0.650 P07902 R123G Disease 0.604 0.478 0.08 28 0.615 P07902 R123Q Disease 0.326 0.393 0.24 6 0.359 P07902 R148G Disease 0.319 0.544 0.44 12 0.429 P07902 R148Q Disease 0.419 0.450 0.62 -10 0.301 P07902 R148W Disease 0.876 0.714 0.06 23 0.800 P07902 R201H Disease 0.538 0.239 0.13 -17 0.544 P07902 R204P Disease 0.603 0.656 0.27 49 0.804 P07902 R231H Disease 0.919 0.845 0.00 49 0.920 P07902 R258C Disease 0.931 0.793 0.00 54 0.916 P07902 R259W Disease 0.917 0.829 0.01 47 0.893 P07902 R262P Disease 0.264 0.562 0.29 18 0.316 P07902 R272G Disease 0.593 0.522 0.05 35 0.770 P07902 R328H Disease 0.703 0.935 0.01 45 0.889 P07902 R333G Disease 0.366 0.751 0.05 48 0.760 P07902 R333Q Disease 0.447 0.683 0.15 49 0.689 P07902 R333W Disease 0.910 0.875 0.01 54 0.928 P07902 S135L Disease 0.495 0.746 0.03 12 0.635 P07902 S135W Disease 0.899 0.842 0.01 31 0.897 P07902 S143L Disease 0.686 0.671 0.17 4 0.789 P07902 S192N Disease 0.455 0.507 0.31 -9 0.401 P07902 S329F Disease 0.711 0.954 0.01 38 0.880 P07902 T138M Disease 0.758 0.585 0.01 46 0.828 P07902 T350A Disease 0.462 0.677 0.31 7 0.501 P07902 V125A Disease 0.369 0.327 0.84 -8 0.180 P07902 V150L Disease 0.374 0.813 0.17 -5 0.540 P07902 V151A Disease 0.633 0.558 0.01 24 0.633 P07902 W154G Disease 0.950 0.907 0.00 57 0.945 P07902 W167R Disease 0.897 0.877 0.12 58 0.930 P07902 W249R Disease 0.929 0.939 0.00 71 0.949 P07902 Y209C Disease 0.966 0.832 0.01 59 0.936 P07902 Y209S Disease 0.916 0.804 0.02 50 0.914 P07902 Y251C Disease 0.953 0.869 0.00 46 0.910 P07902 Y251S Disease 0.891 0.842 0.00 36 0.890 P07902 Y323D Disease 0.923 0.967 0.04 66 0.949 P07902 Y323H Disease 0.409 0.923 0.10 62 0.757 P07910 R167Q Polymorphism 0.529 0.615 0.15 42 0.556 P07911 C77Y Disease NA 0.786 0.06 78 0.915 P07911 C126R Disease NA 0.905 0.00 76 0.951 P07911 C148Y Disease NA 0.836 0.82 65 0.837 P07911 C217R Disease 0.961 0.926 0.00 67 0.941 P07911 C223Y Disease 0.884 0.961 0.00 62 0.946 P07911 C248W Disease 0.944 0.915 0.00 77 0.945 P07911 C255Y Disease 0.896 0.937 0.00 64 0.943 P07911 C300G Disease 0.935 0.906 0.05 46 0.906 P07911 C315R Disease 0.893 0.971 0.00 72 0.945 P07911 G103C Disease NA 0.808 0.02 44 0.845 P07911 N128S Disease NA 0.735 0.14 33 0.807 P07911 T225K Disease 0.687 0.758 0.01 59 0.892 P07942 G860S Polymorphism 0.420 0.651 0.06 41 0.573 P07947 I198V Polymorphism 0.104 0.131 1.00 -9 0.098 P07947 K282R Polymorphism 0.325 0.246 0.38 -6 0.283 P07949 G93S Disease 0.267 0.554 NA 43 0.675 P07949 L40P Disease NA 0.326 NA 31 0.198 P07949 P20L Disease NA 0.235 NA -59 0.105 P07949 P64L Disease NA 0.183 NA 1 0.187 P07949 R67H Disease NA 0.075 NA 15 0.045 P07949 R77C Disease NA 0.375 NA 47 0.315 P07949 S32L Disease NA 0.224 NA 11 0.126 P07949 A432E Disease NA 0.097 NA 3 0.032 P07949 A639G Disease 0.290 0.421 0.08 22 0.292 P07949 A640G Disease 0.135 0.369 0.18 -28 0.220 P07949 A641G Disease 0.145 0.414 0.12 -36 0.218 P07949 A883F Disease 0.684 0.736 0.01 38 0.853 P07949 C142S Disease 0.285 0.318 NA -4 0.179 P07949 C157Y Disease 0.566 0.438 NA 52 0.439 P07949 C197Y Disease 0.566 0.594 NA 56 0.760 P07949 C609G Disease 0.092 0.661 0.05 23 0.658 P07949 C609R Disease 0.453 0.704 0.07 29 0.733 P07949 C609W Disease 0.790 0.722 0.02 51 0.903 P07949 C609Y Disease 0.585 0.680 0.09 45 0.767 P07949 C611G Disease 0.490 0.657 0.03 52 0.691 P07949 C611R Disease 0.660 0.694 0.03 63 0.908 P07949 C611S Disease 0.432 0.647 0.06 48 0.707 P07949 C611W Disease 0.866 0.688 0.01 59 0.889 P07949 C611Y Disease 0.720 0.650 0.06 59 0.837 P07949 C618F Disease 0.453 0.589 0.02 63 0.845 P07949 C618G Disease 0.288 0.613 0.08 58 0.710 P07949 C618R Disease 0.373 0.602 0.02 70 0.713 P07949 C618S Disease 0.204 0.583 0.04 54 0.490 P07949 C618Y Disease 0.492 0.567 0.04 65 0.849 P07949 C620F Disease 0.582 0.492 0.01 55 0.750 P07949 C620G Disease 0.409 0.543 0.03 52 0.721 P07949 C620R Disease 0.574 0.538 0.01 71 0.874 P07949 C620S Disease 0.350 0.454 0.08 52 0.497 P07949 C620W Disease 0.821 0.500 0.00 67 0.932 P07949 C620Y Disease 0.641 0.475 0.03 61 0.775 P07949 C630F Disease 0.708 0.229 0.01 57 0.569 P07949 C630S Disease 0.476 0.209 0.11 47 0.207 P07949 C630Y Disease 0.756 0.317 0.03 60 0.645 P07949 C634F Disease 0.632 0.316 0.05 37 0.562 P07949 C634G Disease 0.456 0.414 0.12 27 0.303 P07949 C634R Disease 0.625 0.397 0.05 55 0.616 P07949 C634S Disease 0.397 0.306 0.16 32 0.372 P07949 C634W Disease 0.848 0.373 0.01 50 0.624 P07949 C634Y Disease 0.688 0.412 0.08 41 0.591 P07949 D489N Polymorphism 0.251 0.128 0.12 5 0.117 P07949 E251K Disease NA 0.111 NA 27 0.054 P07949 E762Q Disease 0.493 0.458 0.05 -11 0.419 P07949 E768D Disease 0.332 0.418 0.14 13 0.368 P07949 E921K Disease 0.241 0.937 0.00 72 0.934 P07949 F174S Disease 0.399 0.206 NA 17 0.285 P07949 F393L Disease NA 0.297 NA 15 0.351 P07949 F893L Disease 0.289 0.879 0.03 58 0.906 P07949 G691S Polymorphism 0.113 0.469 0.18 22 0.247 P07949 G894S Disease 0.996 0.887 0.01 58 0.950 P07949 K907E Disease 0.282 0.679 0.05 55 0.662 P07949 L790F Disease 0.386 0.852 0.03 -1 0.530 P07949 M918T Disease 0.459 0.849 0.14 53 0.628 P07949 M980T Disease 0.459 0.303 0.00 41 0.530 P07949 N359K Disease NA 0.181 NA 12 0.058 P07949 N394H Disease NA 0.260 NA 39 0.342 P07949 N394K Disease NA 0.380 NA 43 0.502 P07949 P198T Disease 0.381 0.173 NA 32 0.185 P07949 P399L Disease NA 0.303 NA 1 0.395 P07949 P973L Disease 0.997 0.839 0.00 40 0.870 P07949 Q626K Disease 0.113 0.144 0.11 -1 0.127 P07949 R114H Disease 0.223 0.105 NA 4 0.077 P07949 R180P Disease 0.490 0.236 NA 26 0.313 P07949 R231H Disease NA 0.167 NA 43 0.213 P07949 R287Q Disease NA 0.218 NA 34 0.194 P07949 R313Q Disease NA 0.072 NA 28 0.067 P07949 R330Q Disease NA 0.067 NA 34 0.068 P07949 R360W Disease NA 0.450 NA 33 0.398 P07949 R475Q Disease 0.088 0.142 0.01 42 0.122 P07949 R600Q Polymorphism 0.062 0.150 0.02 29 0.138 P07949 R749T Polymorphism 0.403 0.472 0.06 15 0.294 P07949 R813Q Disease 0.494 0.394 0.08 63 0.433 P07949 R844L Disease 0.545 0.399 0.06 38 0.541 P07949 R873Q Disease 0.461 0.931 0.00 63 0.937 P07949 R897Q Disease 0.461 0.844 0.00 62 0.883 P07949 R972G Disease 0.462 0.417 0.02 41 0.598 P07949 R982C Polymorphism 0.240 0.214 0.01 38 0.339 P07949 S690P Disease 0.381 0.444 0.04 28 0.456 P07949 S765P Disease 0.589 0.883 0.02 28 0.735 P07949 S767R Disease 0.568 0.416 0.10 24 0.582 P07949 S891A Disease 0.263 0.096 0.30 34 0.309 P07949 S922F Disease 0.675 0.923 0.00 36 0.888 P07949 S922Y Polymorphism 0.693 0.885 0.01 33 0.889 P07949 T278N Polymorphism NA 0.274 NA 35 0.129 P07949 T946M Disease 0.662 0.789 0.01 29 0.788 P07949 V292M Polymorphism NA 0.123 NA 43 0.120 P07949 V376A Disease NA 0.234 NA 17 0.178 P07949 V778I Disease 0.106 0.076 0.35 1 0.134 P07949 V804L Disease 0.274 0.333 0.17 -6 0.299 P07949 V804M Disease 0.545 0.243 0.14 -17 0.560 P07949 Y791F Disease 0.281 0.626 0.04 14 0.406 P07949 Y826S Polymorphism NA 0.233 0.05 19 0.359 P07949 L1061P Disease 0.756 0.435 0.02 42 0.541 P07949 M1064T Disease 0.194 0.267 0.01 47 0.254 P07949 P1039L Disease 0.654 0.221 0.02 41 0.353 P07949 P1039Q Polymorphism 0.712 0.430 0.01 48 0.658 P07949 P1049L Disease 0.654 0.234 0.01 35 0.433 P07949 P1067S Disease 0.194 0.167 0.04 38 0.210 P07951 R91G Disease 0.772 0.931 0.00 24 0.857 P07951 E117A Disease 0.691 0.543 0.05 22 0.729 P07951 E273K Polymorphism 0.121 0.611 0.02 6 0.288 P07951 Q147P Disease 0.818 0.829 0.00 46 0.878 P07954 A117P Disease 0.602 0.931 0.02 38 0.849 P07954 A308T Disease 0.714 0.862 0.00 31 0.719 P07954 D425V Disease 0.835 0.805 0.00 47 0.851 P07954 F312C Disease 0.842 0.884 0.00 51 0.759 P07954 G282V Disease 0.899 0.888 0.00 61 0.817 P07954 H180R Disease 0.829 0.780 0.01 47 0.880 P07954 K230R Disease 0.731 0.835 0.00 46 0.817 P07954 M328R Disease 0.769 0.906 0.00 36 0.796 P07954 N107T Disease 0.735 0.892 0.00 41 0.830 P07954 Q185R Disease 0.730 0.870 0.00 52 0.895 P07954 R233H Disease 0.938 0.882 0.00 70 0.916 P07988 R236C Disease 0.579 0.328 0.02 41 0.553 P07988 R272H Polymorphism 0.336 0.088 0.07 35 0.075 P07992 A266T Polymorphism 0.612 0.645 0.10 41 0.603 P07992 F231L Disease 0.359 0.226 0.55 15 0.358 P07996 N700S Polymorphism 0.580 0.490 0.07 27 0.732 P07996 T523A Polymorphism 0.110 0.397 0.63 27 0.182 P08034 L9W Disease 0.731 0.912 0.00 36 0.797 P08034 T8I Disease 0.283 0.401 0.18 -20 0.394 P08034 T8P Disease 0.351 0.854 0.28 7 0.650 P08034 W3R Disease 0.968 0.970 0.00 47 0.931 P08034 W3S Disease 0.969 0.949 0.00 41 0.937 P08034 Y7C Disease 0.797 0.784 0.16 25 0.843 P08034 A39P Disease 0.730 0.948 0.01 38 0.873 P08034 A39V Disease 0.606 0.862 0.09 -4 0.557 P08034 A40T Disease 0.542 0.827 0.01 5 0.573 P08034 A40V Disease 0.602 0.864 0.14 -13 0.558 P08034 C53S Disease 0.997 0.916 0.00 51 0.952 P08034 C60F Disease 0.972 0.956 0.00 58 0.957 P08034 C64F Disease 0.998 0.960 0.00 65 0.958 P08034 C64S Disease 0.997 0.930 0.00 58 0.958 P08034 E41K Disease 0.379 0.943 0.10 43 0.696 P08034 F29L Disease 0.830 0.851 0.01 0 0.794 P08034 F69L Disease 0.983 0.894 0.00 49 0.938 P08034 G12S Disease 0.856 0.629 0.09 -18 0.807 P08034 G21D Disease 0.793 0.940 0.00 74 0.942 P08034 G59C Disease 0.998 0.905 0.00 53 0.951 P08034 G59R Disease 0.998 0.905 0.00 58 0.956 P08034 H16P Disease 0.824 0.973 0.00 53 0.928 P08034 H94D Disease 0.940 0.910 0.01 65 0.940 P08034 H94Q Disease 0.957 0.853 0.00 53 0.940 P08034 H94Y Disease 0.926 0.848 0.08 18 0.802 P08034 I20S Disease 0.538 0.794 0.01 41 0.832 P08034 I28N Disease 0.649 0.781 0.00 16 0.835 P08034 I28T Disease 0.364 0.556 0.01 4 0.441 P08034 I30N Disease 0.828 0.913 0.00 37 0.888 P08034 I30T Disease 0.636 0.835 0.00 31 0.862 P08034 L25F Disease 0.424 0.935 0.00 21 0.791 P08034 L25P Disease 0.742 0.976 0.00 53 0.920 P08034 L56F Disease 0.285 0.589 0.03 9 0.614 P08034 L81F Disease 0.765 0.669 0.10 -24 0.772 P08034 L83P Disease 0.717 0.890 0.00 19 0.874 P08034 L89P Disease 0.867 0.960 0.00 52 0.930 P08034 L90H Disease 0.890 0.707 0.00 32 0.831 P08034 L90V Disease 0.488 0.450 0.17 -37 0.299 P08034 M34I Disease 0.150 0.680 0.01 16 0.167 P08034 M34K Disease 0.451 0.799 0.00 32 0.819 P08034 M34T Disease 0.360 0.669 0.00 17 0.592 P08034 M34V Disease 0.164 0.720 0.01 -27 0.189 P08034 M93V Disease 0.464 0.686 0.21 -27 0.463 P08034 N14K Disease 0.621 0.847 0.02 22 0.851 P08034 P70A Disease 0.997 0.900 0.00 59 0.955 P08034 P87A Disease 0.502 0.848 0.00 50 0.877 P08034 P87L Disease 0.666 0.876 0.00 46 0.879 P08034 P87S Disease 0.544 0.832 0.00 47 0.871 P08034 Q57H Disease 0.955 0.897 0.00 54 0.939 P08034 Q80R Disease 0.992 0.918 0.00 64 0.953 P08034 R15Q Disease 0.441 0.379 0.33 -11 0.197 P08034 R15W Disease 0.855 0.718 0.00 29 0.784 P08034 R22G Disease 0.549 0.908 0.01 47 0.884 P08034 R22P Disease 0.655 0.944 0.01 67 0.941 P08034 R22Q Disease 0.441 0.805 0.02 49 0.821 P08034 R75P Disease 0.820 0.959 0.00 64 0.941 P08034 R75Q Disease 0.658 0.902 0.00 53 0.894 P08034 R75W Disease 0.933 0.946 0.00 57 0.944 P08034 S11G Disease 0.371 0.820 0.49 -36 0.435 P08034 S26L Disease 0.505 0.908 0.00 5 0.579 P08034 S26W Disease 0.863 0.921 0.00 25 0.887 P08034 S49P Disease 0.461 0.952 0.02 27 0.855 P08034 S49Y Disease 0.651 0.920 0.00 31 0.872 P08034 S50P Disease 0.310 0.778 0.06 7 0.566 P08034 S85C Disease 0.579 0.877 0.10 11 0.589 P08034 S85F Disease 0.622 0.874 0.00 45 0.880 P08034 T55A Disease 0.439 0.859 0.00 56 0.886 P08034 T55I Disease 0.666 0.810 0.00 53 0.773 P08034 T55R Disease 0.709 0.905 0.00 71 0.914 P08034 T86A Disease 0.291 0.761 0.05 14 0.513 P08034 T86N Disease 0.525 0.861 0.03 38 0.863 P08034 T86S Disease 0.331 0.760 0.18 -1 0.491 P08034 V13L Disease 0.739 0.884 0.01 14 0.787 P08034 V13M Disease 0.902 0.899 0.00 47 0.905 P08034 V23A Disease 0.302 0.730 0.00 23 0.577 P08034 V35M Disease 0.499 0.852 0.00 15 0.741 P08034 V37M Disease 0.673 0.720 0.23 -3 0.802 P08034 V38M Disease 0.429 0.834 0.01 14 0.797 P08034 V43M Disease 0.670 0.881 0.00 33 0.849 P08034 V63I Disease 0.618 0.583 0.06 54 0.596 P08034 V84I Disease 0.305 0.597 0.00 14 0.483 P08034 V91M Disease 0.834 0.642 0.03 14 0.800 P08034 V95M Disease 0.431 0.666 0.00 23 0.745 P08034 W24C Disease 0.919 0.934 0.00 58 0.941 P08034 W44L Disease 0.995 0.865 0.00 49 0.939 P08034 W77S Disease 0.998 0.893 0.00 55 0.954 P08034 Y65C Disease 0.903 0.932 0.00 71 0.939 P08034 Y65H Disease 0.723 0.889 0.00 75 0.908 P08034 A147D Disease 0.474 0.781 0.01 26 0.811 P08034 A161P Disease 0.287 0.711 0.26 -4 0.392 P08034 C168R Disease 0.998 0.976 0.00 79 0.946 P08034 C168Y Disease 0.999 0.962 0.00 73 0.957 P08034 C173R Disease 0.996 0.961 0.00 77 0.954 P08034 C179R Disease 0.998 0.954 0.00 71 0.957 P08034 C201R Disease 0.936 0.969 0.01 58 0.942 P08034 C201Y Disease 0.953 0.943 0.01 46 0.920 P08034 C280G Disease NA 0.648 0.00 17 0.657 P08034 D178Y Disease 0.974 0.939 0.00 57 0.952 P08034 E102G Disease 0.356 0.882 0.00 30 0.680 P08034 E146K Disease 0.606 0.951 0.00 64 0.935 P08034 E186K Disease 0.997 0.939 0.00 54 0.957 P08034 E208G Disease 0.994 0.966 0.00 44 0.940 P08034 E208K Disease 0.996 0.950 0.00 60 0.953 P08034 F141L Disease 0.483 0.847 0.01 -33 0.510 P08034 F149I Disease 0.644 0.883 0.00 49 0.890 P08034 F149V Disease 0.651 0.907 0.00 50 0.895 P08034 F153S Disease 0.610 0.708 0.05 24 0.795 P08034 F180L Disease 0.463 0.863 0.01 53 0.881 P08034 F180S Disease 0.760 0.788 0.00 54 0.903 P08034 F193C Disease 0.886 0.937 0.00 59 0.939 P08034 F193L Disease 0.463 0.939 0.00 49 0.895 P08034 F235C Disease 0.474 0.135 0.18 -16 0.217 P08034 G159D Disease 0.800 0.935 0.08 66 0.816 P08034 G159S Disease 0.698 0.879 0.01 58 0.796 P08034 G199R Disease 0.451 0.880 0.36 28 0.820 P08034 H100Y Disease 0.508 0.668 0.07 20 0.537 P08034 H126Y Disease 0.371 0.604 0.01 13 0.472 P08034 I127M Disease 0.627 0.467 0.45 1 0.550 P08034 I127S Disease 0.732 0.689 0.02 30 0.763 P08034 I203N Disease 0.619 0.749 0.01 18 0.782 P08034 I213V Disease 0.068 0.220 0.93 -47 0.158 P08034 K103E Disease 0.402 0.500 0.76 -32 0.397 P08034 K104T Disease 0.372 0.624 0.01 36 0.626 P08034 K124N Disease 0.488 0.900 0.01 34 0.799 P08034 K187E Disease 0.996 0.933 0.00 54 0.957 P08034 L108P Disease 0.327 0.759 0.26 37 0.564 P08034 L131P Disease 0.964 0.966 0.00 64 0.952 P08034 L156F Disease 0.318 0.936 0.11 55 0.732 P08034 L156R Disease 0.602 0.969 0.00 70 0.937 P08034 L204F Disease 0.587 0.930 0.00 17 0.640 P08034 L204V Disease 0.470 0.897 0.00 43 0.878 P08034 L239I Disease 0.108 0.190 0.21 -27 0.160 P08034 M194V Disease 0.443 0.936 0.00 57 0.889 P08034 N205I Disease 0.810 0.867 0.00 27 0.853 P08034 N205S Disease 0.578 0.740 0.01 -4 0.519 P08034 P158A Disease NA 0.530 0.20 9 0.651 P08034 P158R Disease NA 0.667 0.16 15 0.497 P08034 P158S Disease NA 0.662 0.46 -19 0.468 P08034 P172A Disease 0.997 0.834 0.00 59 0.950 P08034 P172L Disease 0.998 0.842 0.00 57 0.953 P08034 P172R Disease 0.998 0.889 0.00 64 0.955 P08034 P172S Disease 0.997 0.790 0.00 58 0.950 P08034 P184L Disease 0.816 0.845 0.00 45 0.883 P08034 P184R Disease 0.827 0.885 0.00 53 0.921 P08034 R107W Disease 0.713 0.610 0.00 29 0.751 P08034 R142E Disease 0.694 0.918 0.01 45 0.882 P08034 R142Q Disease 0.658 0.901 0.01 45 0.880 P08034 R142W Disease 0.933 0.957 0.00 45 0.909 P08034 R164Q Disease 0.472 0.654 0.22 20 0.727 P08034 R164W Disease 0.870 0.839 0.10 30 0.844 P08034 R183C Disease 0.903 0.883 0.00 62 0.931 P08034 R183H Disease 0.780 0.855 0.00 53 0.867 P08034 R183S Disease 0.690 0.826 0.00 53 0.890 P08034 R215Q Disease 0.143 0.625 0.07 6 0.253 P08034 R215W Disease 0.776 0.807 0.00 28 0.855 P08034 R219C Disease 0.851 0.888 0.08 26 0.856 P08034 R219H Disease 0.684 0.766 0.13 8 0.802 P08034 R220G Disease 0.376 0.688 0.53 19 0.485 P08034 R230C Disease 0.410 0.565 0.13 30 0.592 P08034 R230L Disease 0.132 0.487 0.53 31 0.206 P08034 R238H Disease 0.303 0.242 0.12 -42 0.253 P08034 R264C Disease NA 0.117 0.06 0 0.106 P08034 S128P Disease 0.418 0.805 0.12 12 0.552 P08034 S138N Disease 0.672 0.897 0.28 -14 0.776 P08034 S182T Disease 0.525 0.859 0.00 54 0.884 P08034 S198F Disease 0.812 0.950 0.00 41 0.881 P08034 T130I Disease 0.381 0.399 0.02 13 0.515 P08034 T191A Disease 0.439 0.526 0.14 31 0.776 P08034 V120E Disease 0.670 0.258 1.00 -8 0.438 P08034 V125D Disease 0.637 0.726 0.01 31 0.775 P08034 V136A Disease 0.306 0.789 0.01 4 0.537 P08034 V139M Disease 0.382 0.771 0.01 17 0.733 P08034 V177A Disease 0.832 0.907 0.00 55 0.928 P08034 V177E Disease 0.952 0.929 0.00 72 0.944 P08034 V181A Disease 0.354 0.751 0.00 48 0.777 P08034 V181M Disease 0.499 0.748 0.07 31 0.604 P08034 V189G Disease 0.619 0.928 0.00 45 0.887 P08034 V189I Disease 0.060 0.124 1.00 -11 0.038 P08034 V192F Disease 0.459 0.849 0.03 15 0.736 P08034 W133C Disease 0.924 0.793 0.16 21 0.842 P08034 W133R Disease 0.850 0.691 1.00 22 0.714 P08034 Y135C Disease 0.998 0.955 0.00 64 0.957 P08034 Y151S Disease 0.764 0.755 0.03 13 0.780 P08034 Y157C Disease 0.901 0.955 0.00 70 0.939 P08034 Y160H Disease 0.573 0.794 0.00 42 0.752 P08034 Y211H Disease 0.404 0.470 0.58 6 0.371 P08069 R437H Polymorphism NA 0.113 0.27 -5 0.119 P08069 R595H Polymorphism NA 0.197 0.56 -43 0.165 P08069 R605H Polymorphism 0.397 0.637 0.08 61 0.726 P08100 T4K Disease 0.677 0.899 0.00 30 0.851 P08100 F45L Disease 0.111 0.820 0.60 -21 0.191 P08100 G51R Disease 0.536 0.944 0.00 65 0.932 P08100 G51V Disease 0.435 0.842 0.01 50 0.862 P08100 G89D Disease NA 0.821 0.06 21 0.813 P08100 G90D Disease 0.792 0.907 0.00 57 0.916 P08100 L40R Disease 0.694 0.914 0.00 55 0.911 P08100 L46R Disease 0.665 0.888 0.01 40 0.832 P08100 M44T Disease 0.529 0.851 0.00 34 0.754 P08100 N15S Disease NA 0.823 0.01 39 0.763 P08100 P23H Disease 0.986 0.887 0.00 63 0.952 P08100 P23L Disease 0.975 0.890 0.00 54 0.946 P08100 P53R Disease 0.828 0.856 0.18 41 0.823 P08100 Q28H Disease 0.929 0.699 0.00 32 0.869 P08100 T17M Disease NA 0.688 0.00 58 0.832 P08100 T58R Disease 0.793 0.871 0.00 47 0.880 P08100 T94I Disease 0.542 0.514 0.09 -6 0.537 P08100 V87D Disease 0.752 0.873 0.06 13 0.785 P08100 A164E Disease 0.714 0.826 0.00 45 0.869 P08100 A164V Disease 0.604 0.819 0.09 23 0.673 P08100 A292E Disease 0.714 0.880 0.00 53 0.894 P08100 C110F Disease 0.998 0.945 0.00 73 0.951 P08100 C110Y Disease 0.998 0.955 0.00 74 0.951 P08100 C140S Disease 0.952 0.751 0.06 52 0.956 P08100 C167R Disease 0.844 0.889 0.02 42 0.877 P08100 C222R Disease 0.761 0.904 0.00 65 0.916 P08100 D190G Disease 0.865 0.909 0.00 58 0.886 P08100 D190N Disease 0.840 0.823 0.21 36 0.782 P08100 D190Y Disease 0.961 0.938 0.00 71 0.948 P08100 E150K Disease 0.466 0.567 0.54 -12 0.334 P08100 E181K Disease 0.855 0.879 0.00 68 0.922 P08100 F220C Disease 0.887 0.390 0.12 -14 0.579 P08100 G106R Disease 0.979 0.932 0.00 75 0.944 P08100 G106W Disease 0.992 0.877 0.05 70 0.942 P08100 G109R Disease 0.761 0.918 0.03 59 0.920 P08100 G114D Disease 0.855 0.917 0.00 56 0.925 P08100 G182S Disease 0.949 0.827 0.01 51 0.916 P08100 G188E Disease 0.972 0.803 0.08 53 0.969 P08100 G188R Disease 0.977 0.855 0.00 56 0.936 P08100 H211P Disease 0.823 0.873 0.23 59 0.919 P08100 H211R Disease 0.686 0.733 0.07 28 0.824 P08100 K296E Disease 0.993 0.917 0.00 70 0.953 P08100 L125R Disease 0.866 0.948 0.01 56 0.930 P08100 L131P Disease 0.859 0.931 0.00 55 0.929 P08100 M207R Disease 0.729 0.889 0.00 56 0.903 P08100 M216K Disease 0.452 0.897 0.00 46 0.878 P08100 P171L Disease 0.988 0.891 0.00 51 0.949 P08100 P171Q Disease 0.992 0.778 0.00 60 0.947 P08100 P171S Disease 0.981 0.835 0.00 56 0.942 P08100 P267L Disease 0.997 0.897 0.00 53 0.949 P08100 P267R Disease 0.997 0.911 0.00 68 0.953 P08100 P347A Disease 0.025 0.694 0.03 0 0.482 P08100 P347L Disease 0.056 0.753 0.00 2 0.534 P08100 P347Q Disease 0.055 0.869 0.00 8 0.638 P08100 P347R Disease 0.055 0.863 0.00 1 0.597 P08100 P347S Disease 0.045 0.791 0.45 -25 0.282 P08100 R135G Disease 0.993 0.884 0.00 75 0.952 P08100 R135L Disease 0.996 0.939 0.00 72 0.954 P08100 R135W Disease 0.998 0.904 0.00 75 0.952 P08100 S127F Disease 0.969 0.954 0.00 34 0.929 P08100 S186P Disease 0.781 0.817 0.00 61 0.907 P08100 S297R Disease 0.470 0.890 0.02 55 0.889 P08100 T342M Disease 0.401 0.145 0.01 -27 0.245 P08100 V104I Polymorphism 0.121 0.141 0.53 -7 0.126 P08100 V345L Disease 0.086 0.288 0.01 6 0.239 P08100 V345M Disease 0.195 0.325 0.00 -4 0.293 P08100 Y178C Disease 0.927 0.842 0.00 71 0.921 P08100 Y178N Disease 0.852 0.823 0.00 63 0.917 P08107 A467V Polymorphism 0.561 0.811 0.00 26 0.736 P08107 E110D Polymorphism 0.346 0.395 0.18 8 0.369 P08118 D80A Polymorphism 0.609 0.500 0.02 26 0.715 P08118 E91G Polymorphism 0.419 0.302 0.01 42 0.516 P08118 L17S Polymorphism 0.313 0.627 0.10 25 0.389 P08118 Q53R Polymorphism 0.147 0.035 0.86 -4 0.014 P08123 T59P Polymorphism NA 0.408 NA -71 0.298 P08123 A564T Polymorphism 0.188 0.243 NA -12 0.157 P08123 A743G Polymorphism 0.116 0.240 NA -3 0.222 P08123 G211D Disease 0.769 0.879 NA 69 0.975 P08123 G328S Disease NA 0.565 NA 63 0.786 P08123 G331D Disease NA 0.562 NA 73 0.920 P08123 G334C Disease NA 0.526 NA 60 0.838 P08123 G337C Disease NA 0.444 NA 63 0.678 P08123 G337S Disease NA 0.556 NA 68 0.920 P08123 G349C Disease NA 0.423 NA 59 0.655 P08123 G409V Disease NA 0.474 NA 63 0.718 P08123 G433E Disease NA 0.421 NA 63 0.673 P08123 G460S Disease NA 0.580 NA 26 0.519 P08123 G511D Disease 0.991 0.476 NA 77 0.809 P08123 G517R Disease 0.749 0.556 NA 80 0.963 P08123 G547R Disease 0.982 0.695 NA 70 0.982 P08123 G562C Disease 0.998 0.469 NA 34 0.723 P08123 G586R Disease NA 0.766 NA 60 0.926 P08123 G592S Disease 0.975 0.535 NA 29 0.803 P08123 G634V Disease 0.999 0.445 NA 72 0.757 P08123 G637D Disease 0.977 0.500 NA 75 0.974 P08123 G640S Disease 0.989 0.561 NA 56 0.955 P08123 G670D Disease 0.993 0.607 NA 41 0.842 P08123 G676V Disease 0.528 0.488 NA 65 0.773 P08123 G715D Disease 0.979 0.566 NA 75 0.986 P08123 G730C Disease 0.996 0.473 NA 69 0.820 P08123 G736C Disease 0.967 0.439 NA 61 0.805 P08123 G751S Disease 0.987 0.518 NA 73 0.940 P08123 G754R Disease 0.984 0.561 NA 83 0.985 P08123 G766V Disease 0.997 0.562 NA 60 0.959 P08123 G778S Disease 0.993 0.606 NA 64 0.973 P08123 G784R Disease 0.993 0.639 NA 71 0.971 P08123 G787C Disease 0.956 0.657 NA 59 0.952 P08123 G790D Disease 0.995 0.611 NA 70 0.982 P08123 G796S Disease 0.998 0.578 NA 58 0.960 P08123 G835S Disease 0.998 0.724 NA 58 0.928 P08123 G877C Disease 0.985 0.889 NA 63 0.987 P08123 G892D Disease NA 0.844 NA 73 0.984 P08123 G895D Disease NA 0.847 NA 64 0.982 P08123 G949S Disease 0.961 0.802 NA 59 0.955 P08123 G955S Disease 0.967 0.828 NA 54 0.979 P08123 G973V Disease 0.989 0.828 NA 63 0.988 P08123 G997D Disease 0.998 0.770 NA 70 0.973 P08123 I249N Polymorphism NA 0.310 NA 10 0.411 P08123 L344V Polymorphism NA 0.325 NA -6 0.354 P08123 N528S Polymorphism 0.441 0.298 NA 1 0.201 P08123 V270I Polymorphism NA 0.262 NA 9 0.204 P08123 G1012S Disease 0.998 0.694 NA 51 0.894 P08123 G1066D Disease 0.996 0.663 NA 72 0.986 P08123 G1078C Disease 0.995 0.711 NA 70 0.979 P08123 G1096A Disease 0.998 0.512 NA 57 0.907 P08123 G1102R Disease 0.996 0.582 NA 76 0.986 P08123 P1101L Polymorphism 0.706 0.451 NA 15 0.664 P08123 Q1354H Polymorphism NA 0.729 NA -32 0.551 P08123 S1198P Polymorphism NA 0.756 NA -64 0.525 P08123 T1148P Disease NA 0.413 NA -73 0.434 P08134 D120H Polymorphism 0.982 0.903 0.00 74 0.932 P08138 S205L Polymorphism 0.165 0.091 0.35 23 0.093 P08151 D884A Polymorphism 0.165 0.087 0.05 34 0.061 P08151 E1100Q Polymorphism NA 0.097 0.00 -57 0.019 P08183 N21D Polymorphism 0.258 0.195 0.63 -28 0.191 P08183 N44S Polymorphism 0.380 0.267 0.48 -23 0.196 P08183 A599T Polymorphism 0.760 0.333 0.09 16 0.616 P08183 A999T Polymorphism 0.504 0.295 0.46 -37 0.497 P08183 E108K Polymorphism 0.345 0.808 0.62 10 0.454 P08183 E566K Polymorphism 0.925 0.810 0.09 62 0.923 P08183 G185V Polymorphism 0.608 0.594 0.19 7 0.403 P08183 I261V Polymorphism 0.364 0.730 0.15 3 0.141 P08183 I829V Polymorphism 0.284 0.400 0.93 -35 0.251 P08183 R669C Polymorphism 0.780 0.544 0.11 30 0.729 P08183 S893T Polymorphism 0.614 0.543 0.19 7 0.407 P08183 V801M Polymorphism 0.525 0.448 0.49 -14 0.531 P08183 P1051A Polymorphism 0.482 0.272 0.33 -8 0.389 P08183 S1141T Polymorphism 0.378 0.307 0.55 -36 0.269 P08185 D389N Disease 0.540 0.775 0.02 13 0.551 P08185 L115H Disease 0.828 0.417 0.05 6 0.622 P08218 Q177R Polymorphism 0.147 0.270 0.37 -13 0.150 P08235 C645S Disease 0.999 0.814 0.00 64 0.948 P08235 E972G Disease 0.417 0.697 0.01 47 0.805 P08235 F826Y Polymorphism 0.227 0.453 0.07 23 0.232 P08235 G633R Disease 0.935 0.752 0.10 22 0.834 P08235 L769P Disease 0.991 0.967 0.01 63 0.949 P08235 L924P Disease 0.933 0.930 0.00 65 0.947 P08235 L979P Disease 0.832 0.971 0.00 40 0.893 P08235 N444T Polymorphism NA 0.182 0.00 9 0.201 P08235 N554S Polymorphism NA 0.062 0.14 0 0.049 P08235 N770K Disease 0.839 0.561 0.06 42 0.804 P08235 P759S Disease 0.990 0.692 0.04 45 0.947 P08235 Q776R Disease 0.793 0.825 0.03 65 0.909 P08235 R537Q Polymorphism NA 0.123 0.12 48 0.134 P08235 R659S Disease 0.691 0.905 0.00 73 0.922 P08235 S805P Disease 0.717 0.933 0.01 63 0.943 P08235 S815R Disease 0.519 0.548 0.08 57 0.608 P08235 S818L Disease 0.986 0.864 0.02 55 0.945 P08236 C38G Disease 0.115 0.370 0.16 -4 0.199 P08236 P30S Disease 0.671 0.859 0.00 17 0.801 P08236 S52F Disease 0.725 0.322 0.11 41 0.583 P08236 A354V Disease NA 0.366 0.52 10 0.392 P08236 A619V Disease NA 0.682 0.02 9 0.555 P08236 D152G Disease 0.690 0.928 0.07 53 0.911 P08236 D362N Disease NA 0.341 0.38 3 0.314 P08236 E150K Disease 0.461 0.761 0.02 53 0.666 P08236 E540K Disease NA 0.930 0.00 80 0.909 P08236 G136R Disease 0.756 0.891 0.01 72 0.845 P08236 G572D Disease NA 0.532 0.04 5 0.496 P08236 G607A Disease NA 0.847 0.00 60 0.901 P08236 H351Y Disease NA 0.952 0.00 72 0.935 P08236 K350N Disease NA 0.610 0.02 52 0.572 P08236 K606N Disease NA 0.783 0.20 59 0.740 P08236 L176F Disease 0.700 0.524 0.05 23 0.768 P08236 L243P Disease 0.548 0.823 0.21 11 0.811 P08236 N339S Disease NA 0.962 0.00 62 0.927 P08236 P148S Disease 0.839 0.598 0.00 58 0.826 P08236 P364L Disease NA 0.427 0.29 -3 0.490 P08236 P408S Disease NA 0.688 0.35 16 0.547 P08236 P415L Disease NA 0.725 0.32 11 0.555 P08236 R216W Disease 0.960 0.938 0.02 62 0.950 P08236 R374C Disease NA 0.763 0.01 40 0.659 P08236 R382C Disease NA 0.936 0.00 78 0.936 P08236 R382H Disease NA 0.889 0.00 75 0.914 P08236 R435P Disease NA 0.831 0.28 50 0.882 P08236 R477W Disease NA 0.894 0.00 62 0.907 P08236 R577L Disease NA 0.525 0.04 32 0.577 P08236 R611W Disease NA 0.824 0.10 56 0.892 P08236 W627C Disease NA 0.767 0.07 25 0.796 P08236 Y320C Disease 0.933 0.862 0.05 65 0.930 P08236 Y320S Disease 0.837 0.657 0.13 57 0.846 P08236 Y495C Disease NA 0.667 0.16 45 0.657 P08236 Y508C Disease NA 0.886 0.03 66 0.911 P08236 Y626H Disease NA 0.525 0.16 61 0.820 P08237 R39L Disease NA 0.924 0.00 41 0.724 P08237 R39P Disease NA 0.951 0.00 62 0.673 P08237 D543A Disease 0.726 0.838 0.00 54 0.870 P08237 G209D Disease 0.975 0.939 0.00 67 0.945 P08237 R100Q Disease NA 0.487 0.38 -32 0.236 P08237 R696H Disease 0.607 0.823 0.12 -9 0.606 P08237 W686C Disease 0.875 0.692 0.06 38 0.830 P08238 K349E Polymorphism 0.272 0.751 0.56 26 0.435 P08246 G32V Disease 0.808 0.887 0.00 64 0.803 P08246 V98L Polymorphism 0.061 0.159 0.68 -7 0.137 P08246 R191Q Disease 0.142 0.172 0.58 22 0.210 P08246 V177F Disease 0.670 0.500 0.01 14 0.674 P08253 E404K Disease 0.994 0.954 0.00 60 0.958 P08253 R101H Disease 0.977 0.910 0.00 -28 0.879 P08253 V621L Polymorphism 0.051 0.689 0.25 -17 0.027 P08254 K45E Polymorphism NA 0.477 1.00 -45 0.275 P08263 P113Q Polymorphism 0.184 0.296 0.44 17 0.256 P08294 A58T Polymorphism NA 0.110 0.07 -8 0.101 P08294 A91T Polymorphism NA 0.199 0.14 10 0.328 P08311 N125S Polymorphism 0.169 0.168 0.76 -16 0.106 P08397 A31P Disease NA 0.908 0.00 57 0.900 P08397 A31T Disease NA 0.897 0.00 37 0.861 P08397 A55S Disease NA 0.281 0.33 -47 0.215 P08397 D61N Disease NA 0.882 0.00 64 0.919 P08397 D61Y Disease NA 0.951 0.00 67 0.943 P08397 D99G Disease 0.906 0.901 0.00 56 0.922 P08397 D99H Disease 0.883 0.880 0.00 56 0.923 P08397 D99N Disease 0.865 0.880 0.00 54 0.922 P08397 E80G Disease NA 0.804 0.00 46 0.853 P08397 E86V Disease NA 0.331 0.02 -16 0.361 P08397 G24S Disease NA 0.756 0.01 36 0.829 P08397 K98R Disease 0.711 0.807 0.00 49 0.892 P08397 L42S Disease NA 0.961 0.00 42 0.869 P08397 L81P Disease NA 0.923 0.00 45 0.871 P08397 L85R Disease NA 0.894 0.00 51 0.887 P08397 L92P Disease NA 0.903 0.00 18 0.818 P08397 M18I Disease NA 0.541 0.02 10 0.528 P08397 Q34K Disease NA 0.941 0.00 61 0.925 P08397 Q34P Disease NA 0.936 0.00 65 0.942 P08397 Q34R Disease NA 0.925 0.00 62 0.922 P08397 R22C Disease NA 0.911 0.08 44 0.864 P08397 R26C Disease NA 0.955 0.00 76 0.943 P08397 R26H Disease NA 0.950 0.00 72 0.942 P08397 S28N Disease NA 0.769 0.00 56 0.866 P08397 S96F Disease 0.784 0.867 0.00 50 0.902 P08397 T35M Disease NA 0.758 0.00 32 0.834 P08397 T78P Disease NA 0.894 0.00 54 0.896 P08397 V90G Disease NA 0.565 0.01 27 0.772 P08397 V93F Disease 0.560 0.893 0.00 22 0.871 P08397 A122G Disease 0.807 0.642 0.00 22 0.764 P08397 A219D Disease 0.836 0.933 0.00 48 0.893 P08397 A252T Disease 0.447 0.767 0.15 -12 0.569 P08397 A252V Disease 0.500 0.661 0.10 24 0.614 P08397 A270D Disease 0.219 0.534 0.53 3 0.295 P08397 A270G Disease 0.323 0.328 0.33 -15 0.503 P08397 C247F Disease 0.449 0.794 0.00 40 0.844 P08397 C247R Disease 0.570 0.814 0.00 56 0.892 P08397 C261Y Disease 0.976 0.955 0.00 62 0.952 P08397 D178N Disease 0.438 0.515 0.00 12 0.530 P08397 E209K Disease 0.432 0.773 0.02 32 0.671 P08397 E223K Disease 0.552 0.964 0.00 54 0.911 P08397 E250A Disease 0.831 0.831 0.00 59 0.926 P08397 E250K Disease 0.780 0.930 0.00 76 0.938 P08397 E250Q Disease 0.493 0.826 0.00 62 0.899 P08397 E250V Disease 0.925 0.861 0.00 70 0.927 P08397 G111R Disease 0.536 0.854 0.05 46 0.872 P08397 G216D Disease 0.900 0.904 0.00 66 0.925 P08397 G236S Disease 0.283 0.342 0.58 -64 0.143 P08397 G260D Disease 0.826 0.905 0.02 68 0.855 P08397 G274R Disease 0.365 0.929 0.02 25 0.740 P08397 G280R Disease 0.497 0.918 0.00 62 0.916 P08397 G335D Disease 0.333 0.891 0.00 64 0.914 P08397 G335S Disease 0.419 0.788 0.00 47 0.832 P08397 H256N Disease 0.229 0.380 0.13 -4 0.372 P08397 H256Y Disease 0.479 0.333 0.07 -33 0.245 P08397 I113T Disease 0.560 0.614 0.04 39 0.551 P08397 L177R Disease 0.805 0.945 0.00 60 0.919 P08397 L238R Disease 0.913 0.909 0.00 60 0.926 P08397 L244P Disease 0.462 0.838 0.19 26 0.827 P08397 L245R Disease 0.422 0.702 0.37 19 0.395 P08397 L254P Disease 0.849 0.943 0.27 54 0.928 P08397 L278P Disease 0.459 0.965 0.00 43 0.864 P08397 L343P Disease 0.660 0.852 0.02 44 0.873 P08397 M212V Disease 0.213 0.685 0.08 -18 0.312 P08397 P119L Disease 0.462 0.826 0.00 25 0.819 P08397 Q217H Disease 0.937 0.847 0.00 70 0.929 P08397 Q217L Disease 0.914 0.920 0.00 52 0.921 P08397 R116Q Disease 0.830 0.932 0.00 64 0.921 P08397 R116W Disease 0.980 0.938 0.00 65 0.941 P08397 R149L Disease 0.814 0.937 0.00 60 0.916 P08397 R149Q Disease 0.838 0.930 0.00 67 0.915 P08397 R167Q Disease 0.877 0.915 0.00 72 0.914 P08397 R167W Disease 0.984 0.925 0.00 72 0.936 P08397 R173Q Disease 0.945 0.928 0.00 58 0.919 P08397 R173W Disease 0.990 0.930 0.00 62 0.941 P08397 R195C Disease 0.986 0.978 0.00 68 0.912 P08397 R201W Disease 0.907 0.930 0.00 20 0.896 P08397 R225G Disease 0.804 0.953 0.00 53 0.918 P08397 R225Q Disease 0.676 0.938 0.02 56 0.922 P08397 T269I Disease 0.389 0.667 0.00 23 0.739 P08397 V124D Disease 0.926 0.900 0.00 60 0.927 P08397 V202L Disease 0.414 0.641 0.01 -34 0.477 P08397 V222M Disease 0.613 0.895 0.00 20 0.866 P08397 V267M Disease 0.696 0.741 0.03 27 0.838 P08476 Q299P Polymorphism 0.392 0.482 0.52 -46 0.249 P08493 K53E Polymorphism 0.178 0.184 0.35 27 0.138 P08493 T102A Polymorphism 0.284 0.044 1.00 -74 0.023 P08514 L86P Disease 0.826 0.645 0.21 -2 0.721 P08514 A139V Disease 0.879 0.825 0.00 27 0.876 P08514 A581D Disease 0.583 0.838 0.03 -4 0.817 P08514 C161W Disease 0.986 0.939 0.00 56 0.958 P08514 C705R Disease 0.998 0.897 0.00 59 0.952 P08514 E355K Disease 0.898 0.938 0.00 63 0.923 P08514 F202C Disease 0.971 0.917 0.00 26 0.941 P08514 F222L Disease 0.395 0.768 0.03 -13 0.608 P08514 F320S Disease 0.706 0.928 0.03 52 0.915 P08514 G267E Disease 0.953 0.946 0.00 58 0.949 P08514 G273D Disease 0.951 0.934 0.00 47 0.925 P08514 G380D Disease 0.954 0.838 0.00 48 0.919 P08514 G412R Disease 0.823 0.944 0.01 53 0.931 P08514 G449D Disease 0.998 0.907 0.00 73 0.952 P08514 I405T Disease 0.401 0.611 0.01 40 0.777 P08514 I596T Disease 0.892 0.884 0.00 0 0.899 P08514 I874S Polymorphism 0.166 0.303 0.77 -12 0.167 P08514 L214P Disease 0.593 0.952 0.01 -8 0.847 P08514 L752V Disease 0.322 0.368 0.12 4 0.341 P08514 L847P Disease 0.814 0.873 0.02 28 0.826 P08514 P176A Disease 0.919 0.742 0.06 27 0.835 P08514 P176L Disease 0.961 0.804 0.01 -7 0.845 P08514 P943L Disease 0.552 0.236 0.26 -5 0.499 P08514 Q778P Disease 0.220 0.762 0.23 -3 0.307 P08514 R358H Disease 0.548 0.685 0.05 43 0.805 P08514 R755P Disease NA 0.690 0.10 30 0.777 P08514 T207I Disease 0.441 0.649 0.15 24 0.586 P08514 V329F Disease 0.635 0.772 0.01 38 0.689 P08514 V982M Disease 0.493 0.432 0.01 41 0.459 P08514 Y174H Disease 0.463 0.524 0.14 32 0.533 P08514 Y968N Polymorphism 0.949 0.711 0.00 37 0.887 P08514 R1026Q Disease 0.902 0.961 0.00 61 0.953 P08519 I4399M Polymorphism 0.389 0.191 0.18 43 0.374 P08519 L3866V Polymorphism NA 0.114 0.37 -8 0.116 P08519 L3880V Polymorphism NA 0.074 0.34 -21 0.119 P08519 M4106T Polymorphism NA 0.087 0.40 41 0.137 P08519 M4187T Polymorphism 0.152 0.167 0.75 40 0.163 P08519 R3498Q Polymorphism NA 0.922 0.28 11 0.817 P08519 R4524C Polymorphism 0.670 0.796 0.01 31 0.825 P08519 T3907P Polymorphism NA 0.536 0.19 31 0.544 P08559 R10P Disease NA 0.424 0.02 44 0.615 P08559 R72C Disease 0.978 0.939 0.00 65 0.943 P08559 A199T Disease 0.525 0.354 0.40 -14 0.551 P08559 D258A Disease 0.454 0.872 0.00 59 0.904 P08559 D315N Disease 0.884 0.816 0.00 57 0.926 P08559 E333D Polymorphism 0.158 0.317 0.72 -36 0.241 P08559 F205L Disease 0.297 0.521 0.02 14 0.456 P08559 G162R Disease 0.964 0.954 0.03 74 0.933 P08559 H113D Disease 0.221 0.572 0.21 5 0.264 P08559 H292L Disease 0.990 0.918 0.00 72 0.937 P08559 M210V Disease 0.416 0.633 0.01 43 0.786 P08559 P217L Disease 0.963 0.824 0.00 39 0.897 P08559 R263G Disease 0.708 0.484 0.06 20 0.708 P08559 R263Q Disease 0.615 0.441 0.18 -5 0.575 P08559 R288H Disease 0.990 0.832 0.00 65 0.938 P08559 R302C Disease 0.949 0.933 0.00 67 0.930 P08559 R302H Disease 0.881 0.891 0.00 60 0.920 P08559 R378H Disease 0.701 0.857 0.28 18 0.855 P08559 T231A Disease 0.603 0.677 0.02 0 0.571 P08559 V167M Disease 0.797 0.936 0.00 59 0.931 P08559 Y243N Disease 0.677 0.631 0.03 8 0.749 P08571 N204D Polymorphism 0.422 0.312 0.02 65 0.686 P08572 P718S Polymorphism NA 0.356 NA 42 0.416 P08574 L89V Polymorphism 0.255 0.511 0.88 -32 0.397 P08575 H568Q Polymorphism NA 0.128 0.49 34 0.101 P08575 I294L Polymorphism NA 0.059 0.46 -47 0.064 P08575 T191A Polymorphism NA 0.070 0.20 5 0.055 P08575 S1283R Polymorphism 0.233 0.076 0.09 36 0.113 P08581 A320V Polymorphism NA 0.653 0.00 40 0.754 P08581 E168D Polymorphism NA 0.144 0.00 10 0.211 P08581 I316M Polymorphism NA 0.282 0.00 42 0.426 P08581 L238S Polymorphism NA 0.763 0.00 48 0.815 P08581 N375S Polymorphism NA 0.192 0.11 -18 0.313 P08581 R143Q Polymorphism NA 0.412 0.05 24 0.438 P08581 R970C Polymorphism 0.604 0.267 0.07 55 0.542 P08581 S156L Polymorphism NA 0.292 0.00 -11 0.397 P08581 D1228H Disease 0.783 0.654 0.03 45 0.833 P08581 D1228N Disease 0.568 0.604 0.04 24 0.537 P08581 H1094L Disease 0.690 0.602 0.14 15 0.655 P08581 H1094R Disease 0.641 0.374 0.08 -17 0.482 P08581 H1094Y Disease 0.639 0.528 0.05 5 0.514 P08581 H1106D Disease 0.660 0.463 0.06 20 0.493 P08581 K1244R Disease 0.331 0.463 0.39 -3 0.298 P08581 L1195V Disease 0.523 0.885 0.01 45 0.878 P08581 M1131T Disease 0.416 0.915 0.00 51 0.876 P08581 M1250I Disease 0.395 0.713 0.01 34 0.556 P08581 M1250T Disease 0.619 0.582 0.13 38 0.499 P08581 T1173I Disease 0.378 0.204 0.05 12 0.379 P08581 V1092I Disease 0.329 0.585 0.01 40 0.546 P08581 V1188L Disease 0.438 0.690 0.02 -1 0.502 P08581 V1220I Disease 0.331 0.066 0.39 -36 0.173 P08581 Y1230C Disease 0.792 0.801 0.01 10 0.825 P08581 Y1230D Disease 0.719 0.682 0.03 -1 0.610 P08581 Y1230H Disease 0.537 0.440 0.08 -52 0.586 P08582 R294W Polymorphism 0.695 0.456 0.01 22 0.671 P08588 A26V Polymorphism NA 0.194 0.08 -13 0.182 P08588 R31Q Polymorphism NA 0.100 0.45 11 0.096 P08588 H405Y Polymorphism 0.152 0.190 1.00 36 0.210 P08588 R389G Polymorphism 0.794 0.605 0.02 37 0.787 P08590 E56G Disease 0.624 0.906 0.03 41 0.870 P08590 E143K Disease 0.682 0.795 0.05 37 0.825 P08590 M149V Disease 0.364 0.605 0.28 17 0.520 P08590 R154H Disease 0.774 0.841 0.04 20 0.793 P08603 R78G Disease 0.156 0.828 0.38 54 0.266 P08603 V62I Polymorphism 0.136 0.185 0.41 -11 0.138 P08603 C630W Disease 0.830 0.336 0.00 74 0.883 P08603 C673Y Disease 0.707 0.434 0.00 73 0.872 P08603 C915S Disease NA 0.352 0.04 45 0.530 P08603 E850K Disease NA 0.230 0.85 63 0.285 P08603 H893R Disease NA 0.191 0.34 58 0.466 P08603 N997T Polymorphism NA 0.260 0.55 12 0.381 P08603 Q400K Disease NA 0.170 0.95 47 0.152 P08603 Q950H Disease NA 0.207 0.33 53 0.300 P08603 T493R Polymorphism 0.181 0.205 0.54 61 0.245 P08603 T956M Disease NA 0.221 0.20 28 0.380 P08603 W978C Disease NA 0.372 0.02 67 0.657 P08603 Y402H Polymorphism NA 0.217 0.53 21 0.200 P08603 Y951H Disease NA 0.246 0.51 19 0.326 P08603 A1010T Polymorphism NA 0.165 0.43 -19 0.142 P08603 C1043R Disease NA 0.321 0.00 47 0.535 P08603 C1163W Disease NA 0.861 0.00 64 0.858 P08603 E1198A Disease NA 0.422 0.54 51 0.370 P08603 F1199S Disease NA 0.904 0.00 48 0.883 P08603 G1194D Disease NA 0.826 0.04 58 0.720 P08603 L1189R Disease NA 0.802 0.34 37 0.587 P08603 N1050Y Polymorphism NA 0.141 0.02 46 0.380 P08603 P1226S Disease NA 0.774 0.02 39 0.826 P08603 R1215G Disease NA 0.681 0.21 58 0.872 P08603 S1191L Disease NA 0.399 0.63 23 0.329 P08603 T1017I Polymorphism NA 0.225 0.26 11 0.316 P08603 V1007I Polymorphism NA 0.121 0.40 11 0.196 P08603 V1007L Polymorphism NA 0.155 0.67 7 0.127 P08603 V1134G Disease NA 0.600 0.00 43 0.783 P08603 V1197A Disease NA 0.616 0.11 41 0.557 P08603 W1157R Disease NA 0.828 0.03 76 0.811 P08603 W1183L Disease NA 0.505 1.00 58 0.585 P08603 W1183R Disease NA 0.680 0.19 68 0.723 P08603 Y1021F Disease NA 0.237 0.01 9 0.373 P08603 Y1142D Disease NA 0.842 0.01 66 0.909 P08631 A44T Polymorphism NA 0.120 0.57 -32 0.078 P08631 M105L Polymorphism 0.126 0.164 1.00 -7 0.099 P08631 P502Q Polymorphism 0.881 0.826 0.00 55 0.927 P08637 L66R Polymorphism 0.798 0.679 0.05 2 0.682 P08637 F176V Polymorphism 0.289 0.354 0.48 -10 0.153 P08637 F203S Polymorphism 0.251 0.352 0.15 30 0.216 P08637 G147D Polymorphism 0.275 0.508 0.13 0 0.387 P08651 A417S Polymorphism 0.171 0.086 0.92 -21 0.073 P08684 G56D Polymorphism 0.937 0.866 0.01 23 0.892 P08684 L15P Polymorphism 0.861 0.893 0.00 44 0.887 P08684 D174H Polymorphism 0.445 0.844 0.06 28 0.754 P08684 F189S Polymorphism 0.928 0.877 0.00 62 0.927 P08684 I118V Polymorphism 0.139 0.118 1.00 -5 0.109 P08684 L293P Polymorphism 0.438 0.878 0.24 16 0.758 P08684 M445T Polymorphism 0.752 0.848 0.04 27 0.678 P08684 P416L Polymorphism 0.998 0.826 0.00 47 0.908 P08684 R130Q Polymorphism 0.883 0.881 0.00 69 0.929 P08684 S222P Polymorphism 0.608 0.753 0.13 35 0.711 P08684 T185S Polymorphism 0.442 0.423 0.22 -18 0.295 P08684 T349N Polymorphism 0.431 0.310 0.46 -35 0.197 P08684 T363M Polymorphism 0.700 0.690 0.00 27 0.800 P08686 A15T Disease 0.090 0.157 0.44 -20 0.077 P08686 G64E Disease 0.709 0.959 0.00 66 0.947 P08686 G90V Disease 0.558 0.757 0.00 28 0.808 P08686 H62L Disease 0.205 0.707 0.42 21 0.560 P08686 P30L Disease 0.139 0.696 1.00 20 0.365 P08686 P30Q Disease 0.318 0.786 0.03 42 0.737 P08686 A362V Disease 0.558 0.125 0.13 14 0.383 P08686 C169Y Disease 0.750 0.593 0.01 16 0.683 P08686 D183E Polymorphism 0.067 0.220 0.44 -30 0.202 P08686 E380D Disease 0.230 0.500 0.06 -2 0.358 P08686 G178A Disease 0.616 0.611 0.15 38 0.562 P08686 G291C Disease 0.871 0.761 0.00 43 0.845 P08686 G291R Disease 0.814 0.905 0.00 61 0.796 P08686 G291S Disease 0.645 0.713 0.02 41 0.820 P08686 G424S Disease 0.618 0.899 0.00 72 0.903 P08686 H365Y Disease 0.636 0.728 0.00 54 0.862 P08686 I172N Disease 0.526 0.822 0.00 52 0.840 P08686 I236N Disease 0.602 0.500 0.00 17 0.588 P08686 L261P Disease 0.817 0.906 0.00 63 0.929 P08686 L300F Disease 0.551 0.786 0.08 47 0.777 P08686 L317M Disease 0.391 0.241 0.01 2 0.387 P08686 L363W Disease 0.835 0.453 0.00 39 0.699 P08686 M239K Disease 0.107 0.206 1.00 -25 0.120 P08686 M283L Disease 0.247 0.700 0.35 -20 0.254 P08686 P105L Disease 0.155 0.364 0.06 0 0.154 P08686 P453S Disease NA 0.706 0.08 5 0.533 P08686 P482S Disease NA 0.541 0.15 19 0.504 P08686 R124H Disease 0.205 0.244 0.11 -46 0.151 P08686 R339H Disease 0.618 0.747 0.01 39 0.821 P08686 R341P Disease 0.617 0.848 0.14 16 0.823 P08686 R341W Disease 0.848 0.746 0.09 32 0.802 P08686 R354C Disease 0.847 0.863 0.00 71 0.916 P08686 R354H Disease 0.441 0.816 0.00 72 0.880 P08686 R356P Disease 0.780 0.785 0.01 15 0.765 P08686 R356Q Disease 0.598 0.248 0.07 14 0.588 P08686 R356W Disease 0.916 0.696 0.00 12 0.811 P08686 R408C Disease 0.496 0.738 0.00 53 0.813 P08686 R426H Disease 0.727 0.893 0.00 76 0.903 P08686 R435C Disease 0.830 0.730 0.00 38 0.849 P08686 R479L Disease NA 0.453 0.05 3 0.367 P08686 R483P Disease NA 0.897 0.00 46 0.879 P08686 R483Q Disease NA 0.748 0.00 40 0.708 P08686 R483W Disease NA 0.867 0.00 62 0.903 P08686 S301Y Disease 0.633 0.395 0.09 8 0.545 P08686 V211L Disease 0.112 0.203 0.25 -32 0.164 P08686 V237E Disease 0.671 0.520 0.00 45 0.777 P08686 V281G Disease 0.729 0.719 0.01 4 0.818 P08686 V281L Disease 0.162 0.278 0.77 -33 0.208 P08697 A2V Polymorphism NA 0.171 0.08 -44 0.026 P08697 R434K Polymorphism 0.398 0.318 0.29 8 0.397 P08697 V411M Disease 0.546 0.276 0.01 38 0.621 P08700 N60S Polymorphism 0.320 0.076 0.04 13 0.073 P08700 R15H Polymorphism 0.438 0.146 0.09 4 0.064 P08708 E36K Polymorphism 0.276 0.711 0.13 -12 0.439 P08709 A352T Polymorphism 0.392 0.180 0.67 -27 0.146 P08709 E445K Polymorphism 0.238 0.210 1.00 -3 0.136 P08709 R413Q Polymorphism 0.243 0.156 0.12 8 0.175 P08709 T367S Polymorphism 0.529 0.080 0.20 -7 0.132 P08709 V295D Polymorphism 0.493 0.383 0.62 6 0.175 P08779 K354N Disease 0.884 0.597 0.00 -8 0.799 P08779 L124R Disease 0.990 0.944 0.00 59 0.942 P08779 L128Q Disease 0.991 0.894 0.00 36 0.922 P08779 L132P Disease 0.986 0.939 0.00 49 0.933 P08779 M121T Disease 0.981 0.921 0.00 38 0.913 P08779 N125S Disease 0.977 0.903 0.00 27 0.910 P08779 Q122P Disease 0.970 0.966 0.00 40 0.897 P08779 R127C Disease 0.990 0.937 0.00 37 0.915 P08779 R127P Disease 0.976 0.966 0.00 57 0.942 P08842 C446Y Disease 0.896 0.753 0.10 8 0.849 P08842 G380R Disease 0.769 0.691 0.02 50 0.889 P08842 H444R Disease 0.723 0.716 0.03 51 0.792 P08842 Q560P Disease 0.465 0.879 0.37 11 0.552 P08842 S341L Disease 0.737 0.917 0.01 54 0.915 P08842 W372R Disease 0.699 0.843 0.00 67 0.868 P08842 W372S Disease 0.667 0.763 0.01 59 0.852 P08887 V385I Polymorphism 0.085 0.024 0.43 -52 0.044 P08908 G273D Polymorphism NA 0.761 0.20 24 0.591 P08910 R253Q Polymorphism 0.189 0.657 0.40 65 0.416 P08913 N251K Polymorphism NA 0.290 0.82 6 0.312 P08922 I537M Polymorphism NA 0.145 0.22 26 0.128 P08922 N790S Polymorphism NA 0.134 0.16 26 0.123 P08922 S370P Polymorphism NA 0.201 0.08 39 0.190 P08922 T145P Polymorphism NA 0.152 0.03 49 0.158 P08922 Y338C Polymorphism NA 0.214 0.02 51 0.410 P08922 C1370R Polymorphism 0.642 0.651 0.00 59 0.879 P08922 D1776H Polymorphism 0.613 0.353 0.00 49 0.606 P08922 D2213E Polymorphism 0.089 0.156 0.59 -1 0.099 P08922 D2213N Polymorphism 0.073 0.308 0.63 -9 0.139 P08922 E1902K Polymorphism 0.005 0.215 0.46 51 0.226 P08922 F1439S Polymorphism 0.534 0.353 0.20 26 0.478 P08922 N2240K Polymorphism NA 0.434 0.56 45 0.490 P08922 R1506G Polymorphism 0.253 0.092 0.24 41 0.082 P08922 R2039H Polymorphism 0.520 0.864 0.00 49 0.798 P08922 S2229C Polymorphism 0.019 0.541 0.27 25 0.278 P08922 Y1239F Polymorphism NA 0.291 0.69 18 0.208 P08922 Y1353S Polymorphism 0.522 0.211 0.00 45 0.446 P09093 S25P Polymorphism 0.056 0.316 0.27 -73 0.131 P09104 P264A Polymorphism NA 0.232 0.40 -3 0.310 P09110 E172D Polymorphism 0.230 0.146 0.61 -30 0.124 P09131 V354I Polymorphism 0.585 0.067 0.60 -23 0.122 P09132 A4T Polymorphism NA 0.069 0.29 -14 0.033 P09172 G12S Polymorphism NA 0.033 1.00 -26 0.004 P09172 D114E Disease NA 0.744 0.00 65 0.847 P09172 D345N Disease 0.953 0.951 0.00 76 0.952 P09172 E181Q Polymorphism NA 0.152 0.49 -27 0.189 P09172 L317P Polymorphism 0.865 0.876 0.01 28 0.886 P09172 R549C Polymorphism 0.552 0.122 0.10 24 0.319 P09172 V101M Disease NA 0.640 0.02 25 0.750 P09210 S112T Polymorphism 0.104 0.273 0.61 -3 0.145 P09210 V149A Polymorphism 0.586 0.855 0.00 21 0.682 P09211 G169D Polymorphism 0.209 0.738 0.80 7 0.305 P09237 R77H Polymorphism 0.129 0.500 0.10 -29 0.211 P09238 L4V Polymorphism NA 0.349 0.01 -72 0.319 P09238 R53K Polymorphism NA 0.647 1.00 -53 0.353 P09238 L440F Polymorphism 0.065 0.586 1.00 -28 0.043 P09326 L241S Polymorphism 0.679 0.474 0.00 32 0.692 P09327 K254R Polymorphism 0.127 0.439 0.40 -20 0.255 P09417 G17R Disease 0.874 0.955 0.00 76 0.954 P09417 G17V Disease 0.861 0.960 0.00 66 0.954 P09417 G18D Disease 0.674 0.921 0.00 71 0.921 P09417 G23D Disease 0.832 0.969 0.00 75 0.952 P09417 L14P Disease 0.847 0.881 0.00 34 0.872 P09417 L74P Disease 0.375 0.816 0.16 35 0.669 P09417 Q66R Disease 0.299 0.114 0.80 2 0.222 P09417 S51T Polymorphism 0.220 0.148 0.62 -32 0.217 P09417 W36R Disease 0.307 0.791 0.45 39 0.552 P09417 F212C Disease 0.731 0.913 0.02 30 0.863 P09417 G149R Disease 0.732 0.771 0.19 45 0.805 P09417 G151S Disease 0.740 0.764 0.22 -11 0.782 P09417 G170S Disease 0.360 0.703 0.00 -16 0.500 P09417 H158Y Disease 0.733 0.857 0.63 48 0.815 P09417 P145L Disease 0.614 0.519 0.03 43 0.654 P09417 W108G Disease 0.604 0.856 0.06 41 0.780 P09417 Y150C Disease 0.916 0.954 0.00 82 0.952 P09467 A177D Disease 0.866 0.854 0.01 41 0.878 P09467 F194S Disease 0.898 0.846 0.00 47 0.900 P09467 F233I Polymorphism 0.461 0.244 0.13 -24 0.373 P09467 G164S Disease 0.714 0.929 0.02 47 0.888 P09467 P284R Disease 0.975 0.910 0.00 68 0.950 P09467 R255L Polymorphism 0.843 0.921 0.00 48 0.904 P09467 V325A Polymorphism 0.817 0.828 0.00 26 0.844 P09486 N70S Polymorphism 0.425 0.267 0.16 18 0.369 P09488 S210T Polymorphism 0.096 0.183 0.42 2 0.120 P09493 A63V Disease 0.297 0.074 0.12 -20 0.189 P09493 E40K Disease 0.303 0.596 0.02 38 0.677 P09493 E54K Disease 0.497 0.512 0.18 42 0.530 P09493 D175N Disease 0.231 0.652 0.01 0 0.466 P09493 E180G Disease 0.823 0.894 0.00 27 0.862 P09493 E180V Disease 0.910 0.837 0.00 26 0.899 P09543 Q207R Polymorphism 0.194 0.122 0.00 -2 0.136 P09544 C294F Polymorphism 0.997 0.946 0.00 60 0.955 P09544 R299W Polymorphism 0.807 0.712 0.02 -24 0.501 P09601 D7H Polymorphism 0.140 0.118 0.02 -1 0.141 P09601 P106L Polymorphism 0.361 0.192 0.27 -9 0.350 P09603 A531V Polymorphism 0.095 0.027 0.60 2 0.051 P09603 L408P Polymorphism 0.143 0.120 0.29 -1 0.047 P09619 I29F Polymorphism NA 0.192 0.06 -5 0.307 P09619 E282K Polymorphism 0.241 0.181 0.93 7 0.271 P09619 E485K Polymorphism NA 0.238 0.76 10 0.308 P09619 N718Y Polymorphism NA 0.652 0.03 36 0.631 P09619 P345S Polymorphism 0.083 0.161 0.48 -32 0.057 P09619 S180F Polymorphism 0.192 0.454 0.05 50 0.441 P09622 L331V Polymorphism 0.281 0.149 0.98 -25 0.093 P09651 N73S Polymorphism 0.185 0.349 0.68 -28 0.228 P09661 R234H Polymorphism 0.334 0.086 0.10 -25 0.088 P09668 A23T Polymorphism 0.124 0.156 0.59 -61 0.143 P09668 G11R Polymorphism NA 0.543 0.12 20 0.703 P09681 N146S Polymorphism 0.168 0.087 0.26 -18 0.043 P09681 S103G Polymorphism 0.125 0.034 0.94 -55 0.020 P09693 V131F Polymorphism 0.549 0.706 0.02 23 0.803 P09758 D216E Polymorphism 0.157 0.500 0.16 -12 0.248 P09758 E147D Polymorphism 0.405 0.477 0.12 -21 0.500 P09769 S130R Polymorphism 0.626 0.782 0.03 47 0.692 P09769 T110I Polymorphism 0.391 0.401 0.03 31 0.510 P09848 Q268H Disease NA 0.178 0.15 18 0.168 P09848 G1363S Disease NA 0.798 0.03 -25 0.577 P09871 R119H Polymorphism NA 0.668 0.12 55 0.793 P09874 F54L Polymorphism 0.201 0.192 0.65 21 0.216 P09874 K940R Polymorphism 0.624 0.287 0.27 15 0.587 P09874 P377S Polymorphism 0.201 0.238 0.75 -21 0.188 P09874 V762A Polymorphism 0.274 0.201 0.66 7 0.285 P09913 E79A Polymorphism 0.178 0.157 0.46 -23 0.142 P09913 K121R Polymorphism 0.201 0.104 0.80 -34 0.117 P09919 L157M Polymorphism 0.362 0.053 0.21 21 0.065 P09923 R144H Polymorphism 0.324 0.464 0.60 -7 0.367 P09936 S18Y Polymorphism 0.704 0.460 0.10 -39 0.452 P09960 Y131H Polymorphism 0.767 0.776 0.00 59 0.863 P0C024 E181G Polymorphism NA 0.579 0.03 17 0.573 P0C091 D412N Polymorphism NA 0.069 0.46 52 0.129 P0C0L4 D727N Polymorphism 0.163 0.154 0.07 4 0.148 P0C0L4 P726L Polymorphism 0.243 0.189 0.14 15 0.282 P0C0L4 D1073G Polymorphism 0.164 0.724 0.21 8 0.308 P0C0L4 L1210R Polymorphism 0.098 0.266 0.63 -5 0.154 P0C0L4 N1176S Polymorphism 0.098 0.279 1.00 9 0.145 P0C0L4 S1286A Polymorphism 0.141 0.214 0.56 -7 0.148 P0C0L5 A907T Polymorphism 0.182 0.568 0.02 7 0.444 P0C0L5 S347Y Polymorphism NA 0.255 0.08 34 0.416 P0C0L5 D1073G Polymorphism 0.164 0.724 0.21 19 0.329 P0C0L5 S1201T Polymorphism 0.129 0.149 0.36 -42 0.137 P0C0L5 S1286A Polymorphism 0.141 0.215 0.55 -26 0.147 P0C0P6 S14L Polymorphism NA 0.213 0.88 -45 0.057 P0C0P6 V75L Polymorphism NA 0.196 0.00 57 0.366 P0C1H6 R22H Polymorphism NA 0.078 NA 26 0.046 P0C1S8 K8T Polymorphism NA 0.134 0.03 -2 0.159 P0C1S8 Y526D Polymorphism 0.319 0.123 0.34 14 0.069 P0C221 G164R Polymorphism NA 0.155 0.11 36 0.090 P0C221 G507E Polymorphism NA 0.028 0.37 -17 0.010 P0C221 S689R Polymorphism NA 0.070 0.06 27 0.051 P0C263 A41E Polymorphism NA 0.371 0.85 1 0.266 P0C263 E20K Polymorphism NA 0.096 0.11 43 0.098 P0C263 G102D Polymorphism 0.266 0.527 0.45 -11 0.297 P0C2Y1 E170D Polymorphism 0.453 0.888 0.05 4 0.772 P0C5J1 R285S Polymorphism 0.855 0.927 0.01 63 0.951 P0C671 L582V Polymorphism 0.297 0.101 NA 45 0.121 P0C6C1 P369R Polymorphism NA 0.046 0.09 47 0.079 P0C6P0 C81R Polymorphism NA 0.232 0.87 25 0.063 P0C6P0 T54I Polymorphism NA 0.817 0.00 21 0.595 P0C6S8 R426H Polymorphism 0.536 0.361 0.35 -6 0.500 P0C7H9 A161G Polymorphism 0.794 0.797 0.02 43 0.831 P0C7H9 P494L Polymorphism NA 0.058 0.72 -20 0.011 P0C7I6 C393S Polymorphism NA 0.044 NA 10 0.020 P0C7P3 Q93R Polymorphism 0.445 0.235 0.38 39 0.281 P0C7P3 S880I Polymorphism 0.488 0.133 0.49 29 0.102 P0C7P3 Y912F Polymorphism NA 0.032 NA 3 0.027 P0C7Q3 T236N Polymorphism 0.458 0.333 0.42 -40 0.153 P0C7T5 S313P Polymorphism NA 0.277 0.29 11 0.106 P0C7U3 R200G Polymorphism 0.582 0.531 0.38 18 0.484 P0C7V0 A112E Polymorphism NA 0.191 NA 31 0.027 P0C7V8 T316A Polymorphism 0.181 0.162 0.53 -7 0.210 P0C7X2 S131I Polymorphism NA 0.163 0.24 18 0.251 P0C7X4 A106P Polymorphism 0.265 0.791 0.15 31 0.627 P0C7X5 V8A Polymorphism NA 0.613 0.00 54 0.734 P0C7X5 A28S Polymorphism NA 0.622 0.36 12 0.432 P0C7X5 K60T Polymorphism NA 0.416 0.26 15 0.373 P0C7X5 G163E Polymorphism NA 0.382 1.00 0 0.246 P0C7X5 R189C Polymorphism NA 0.268 0.15 10 0.407 P0C7X5 R561H Polymorphism 0.283 0.361 1.00 -28 0.020 P0C7X5 V276I Polymorphism 0.147 0.222 0.26 -44 0.232 P0C860 L99I Polymorphism NA 0.042 1.00 -37 0.060 P0C860 K316E Polymorphism 0.379 0.231 0.04 27 0.170 P0C860 S145N Polymorphism 0.108 0.051 0.52 -24 0.025 P0C862 L6F Polymorphism 0.069 0.409 0.00 8 0.222 P0C862 M219V Polymorphism 0.041 0.208 1.00 34 0.157 P0C862 V301M Polymorphism 0.252 0.718 0.00 26 0.704 P0C867 S98L Polymorphism NA 0.444 NA 23 0.095 P0C869 R191C Polymorphism 0.596 0.143 0.09 37 0.164 P0C869 R391H Polymorphism 0.484 0.227 0.12 19 0.404 P0CB38 H370P Polymorphism NA 0.280 NA 16 0.143 P0CB38 S331N Polymorphism 0.314 0.775 0.08 35 0.585 P10070 P932S Disease 0.304 0.084 0.09 12 0.105 P10070 R479G Disease 0.851 0.459 0.00 58 0.732 P10070 S579I Polymorphism 0.969 0.208 0.00 48 0.868 P10070 M1444I Disease NA 0.183 0.14 33 0.120 P10070 P1554L Disease NA 0.186 0.00 33 0.332 P10071 A934P Disease 0.825 0.779 0.00 28 0.866 P10071 C515G Disease 0.992 0.832 0.00 51 0.990 P10071 C520Y Disease 0.998 0.807 0.00 68 0.995 P10071 D440E Polymorphism 0.076 0.110 1.00 5 0.070 P10071 G727R Disease 0.924 0.596 0.00 36 0.749 P10071 I808M Disease 0.353 0.193 0.03 40 0.285 P10071 P707S Disease 0.859 0.449 0.01 0 0.637 P10071 R625W Disease 0.990 0.218 0.00 57 0.756 P10071 G1336E Polymorphism 0.582 0.149 0.00 35 0.179 P10071 R1537C Polymorphism NA 0.475 0.00 49 0.452 P10072 R448H Polymorphism 0.087 0.391 0.01 40 0.432 P10075 A180T Polymorphism 0.402 0.275 0.00 -16 0.478 P10082 D95H Polymorphism 0.311 0.085 0.54 -8 0.066 P10144 P94A Polymorphism 0.383 0.050 0.62 -22 0.092 P10153 H100Q Polymorphism 0.113 0.056 1.00 0 0.024 P10163 P186R Polymorphism 0.927 0.091 0.28 16 0.066 P10163 P200H Polymorphism 0.865 0.104 0.12 46 0.092 P10244 I624M Polymorphism NA 0.223 0.14 -13 0.206 P10244 S427G Polymorphism NA 0.130 0.48 36 0.130 P10253 A237V Disease 0.380 0.256 0.25 -34 0.382 P10253 A445P Disease 0.840 0.827 0.02 44 0.868 P10253 A880D Disease 0.523 0.756 0.17 39 0.726 P10253 C103G Disease NA 0.991 0.00 58 0.916 P10253 C374R Disease 0.665 0.874 0.02 73 0.852 P10253 C647W Disease 0.990 0.936 0.00 67 0.933 P10253 D404N Disease 0.916 0.765 0.00 69 0.890 P10253 D489N Disease 0.991 0.882 0.00 64 0.944 P10253 D645E Disease 0.279 0.894 0.02 69 0.812 P10253 D645H Disease 0.633 0.911 0.01 79 0.856 P10253 D645N Disease 0.391 0.907 0.03 69 0.731 P10253 E262K Disease 0.359 0.827 0.02 48 0.800 P10253 E521K Disease 0.659 0.951 0.00 60 0.852 P10253 E579K Disease 0.359 0.603 0.23 36 0.656 P10253 E689K Polymorphism 0.359 0.551 0.21 -6 0.168 P10253 G219R Disease 0.666 0.763 0.56 25 0.777 P10253 G293R Disease 0.666 0.905 0.00 59 0.861 P10253 G309R Disease 0.930 0.952 0.00 64 0.925 P10253 G377R Disease 0.666 0.694 0.02 52 0.848 P10253 G478R Disease 0.923 0.935 0.00 67 0.889 P10253 G549R Disease NA 0.751 0.07 40 0.636 P10253 G576A Polymorphism 0.790 0.624 0.00 26 0.672 P10253 G576S Polymorphism 0.819 0.726 0.00 44 0.745 P10253 G607D Disease 0.888 0.875 0.00 61 0.888 P10253 G615R Disease 0.994 0.873 0.00 77 0.948 P10253 G638W Disease 0.975 0.877 0.00 75 0.905 P10253 G643R Disease 0.974 0.900 0.00 78 0.898 P10253 G648S Disease 0.941 0.932 0.00 61 0.884 P10253 H308L Disease 0.489 0.785 0.11 46 0.662 P10253 H308P Disease 0.641 0.880 0.03 58 0.920 P10253 H612Q Disease 0.873 0.564 0.01 39 0.811 P10253 L208P Disease 0.727 0.598 0.16 1 0.746 P10253 L299R Disease 0.629 0.912 0.01 54 0.913 P10253 L312R Disease 0.863 0.950 0.00 57 0.929 P10253 L355P Disease 0.727 0.715 0.13 14 0.828 P10253 L405P Disease 0.727 0.757 0.01 31 0.859 P10253 L552P Disease NA 0.815 0.21 47 0.789 P10253 L901Q Disease 0.664 0.327 0.02 -13 0.618 P10253 M318T Disease 0.740 0.832 0.01 23 0.666 P10253 M408V Disease 0.883 0.599 0.00 59 0.890 P10253 M519T Disease 0.712 0.929 0.00 58 0.856 P10253 M519V Disease 0.515 0.855 0.01 56 0.778 P10253 P285R Disease 0.925 0.701 0.11 38 0.855 P10253 P324L Disease 0.921 0.491 0.05 11 0.735 P10253 P361L Disease 0.975 0.862 0.00 38 0.933 P10253 P457L Disease 0.609 0.387 0.07 -3 0.602 P10253 P522A Disease 0.450 0.767 0.45 16 0.408 P10253 P545L Disease NA 0.404 1.00 7 0.432 P10253 P768R Disease 0.973 0.943 0.00 70 0.859 P10253 Q401R Disease 0.636 0.453 0.03 61 0.908 P10253 R224W Disease 0.987 0.940 0.00 62 0.956 P10253 R375L Disease 0.863 0.900 0.00 67 0.891 P10253 R437C Disease 0.794 0.769 0.00 13 0.857 P10253 R585M Disease 0.712 0.634 0.06 13 0.737 P10253 R600C Disease 0.996 0.924 0.00 77 0.951 P10253 R600H Disease 0.994 0.905 0.00 78 0.943 P10253 R660H Disease 0.962 0.893 0.00 65 0.883 P10253 R672Q Disease 0.930 0.804 0.00 70 0.884 P10253 R672T Disease 0.953 0.834 0.00 71 0.882 P10253 R672W Disease 0.987 0.880 0.00 67 0.926 P10253 R702C Disease 0.983 0.814 0.00 59 0.922 P10253 R725W Disease 0.962 0.945 0.00 62 0.889 P10253 S529V Disease 0.699 0.261 0.05 9 0.613 P10253 S566P Disease 0.523 0.837 0.21 -16 0.481 P10253 S599Y Disease 0.657 0.739 0.00 48 0.850 P10253 S619R Disease 0.492 0.803 0.01 64 0.778 P10253 T927I Polymorphism 0.427 0.348 0.02 13 0.441 P10253 V816I Polymorphism 0.171 0.283 0.22 -17 0.253 P10253 V949D Disease NA 0.661 0.01 43 0.765 P10253 W330G Disease 0.629 0.652 0.00 58 0.793 P10253 W402R Disease 0.654 0.715 0.36 57 0.821 P10253 W481R Disease 0.976 0.953 0.00 72 0.899 P10253 Y191C Disease NA 0.804 0.00 59 0.890 P10253 Y292C Disease 0.783 0.951 0.00 73 0.928 P10253 Y455F Disease 0.443 0.772 0.00 35 0.600 P10253 Y575S Disease 0.781 0.788 0.00 54 0.877 P10275 E2K Disease NA 0.336 0.00 9 0.271 P10275 A573D Disease 0.672 0.858 0.00 66 0.915 P10275 A596T Disease 0.747 0.348 0.11 24 0.602 P10275 A645D Polymorphism 0.176 0.269 0.22 37 0.296 P10275 A687V Disease 0.690 0.299 0.07 17 0.581 P10275 A748D Disease 0.680 0.693 0.07 51 0.824 P10275 A765T Disease 0.743 0.747 0.03 26 0.817 P10275 A765V Disease 0.806 0.661 0.03 31 0.801 P10275 A870G Disease 0.427 0.492 0.22 11 0.343 P10275 A870V Disease 0.111 0.187 0.73 11 0.115 P10275 C559Y Disease 0.999 0.941 0.00 60 0.955 P10275 C576F Disease 0.943 0.943 0.00 68 0.945 P10275 C576R Disease 0.937 0.938 0.00 75 0.950 P10275 C579F Disease 0.945 0.960 0.00 63 0.951 P10275 C579Y Disease 0.955 0.960 0.00 63 0.955 P10275 C601F Disease 0.999 0.908 0.00 62 0.952 P10275 C611Y Disease 0.999 0.897 0.00 72 0.948 P10275 C686R Disease 0.393 0.783 0.23 54 0.657 P10275 C784Y Disease 0.952 0.367 0.12 47 0.604 P10275 C806Y Disease 0.895 0.887 0.03 45 0.912 P10275 D604Y Disease 0.950 0.890 0.00 60 0.935 P10275 D695H Disease 0.712 0.782 0.02 42 0.826 P10275 D695N Disease 0.454 0.643 0.12 19 0.495 P10275 D695V Disease 0.780 0.781 0.03 33 0.787 P10275 D732N Disease 0.981 0.916 0.00 47 0.934 P10275 D732Y Disease 0.995 0.941 0.00 58 0.952 P10275 D767E Disease 0.707 0.602 0.05 33 0.784 P10275 D864G Disease 0.823 0.899 0.16 36 0.877 P10275 D864N Disease 0.789 0.781 0.07 22 0.850 P10275 D879Y Disease NA 0.670 0.47 45 0.558 P10275 E681K Disease 0.820 0.878 0.02 28 0.798 P10275 E772A Disease 0.542 0.237 0.05 42 0.590 P10275 E772G Disease 0.570 0.343 0.02 44 0.609 P10275 E793D Polymorphism 0.502 0.175 0.03 9 0.283 P10275 F582S Disease 0.989 0.940 0.00 55 0.954 P10275 F582Y Disease 0.941 0.828 0.00 54 0.935 P10275 F754L Disease 0.421 0.305 0.16 27 0.214 P10275 F754V Disease 0.599 0.286 0.27 41 0.383 P10275 F764L Disease 0.707 0.832 0.08 35 0.784 P10275 F794S Disease 0.787 0.624 0.01 36 0.793 P10275 F827V Disease 0.828 0.448 0.52 36 0.575 P10275 F856L Disease 0.501 0.751 0.22 29 0.564 P10275 F916L Disease 0.659 0.947 0.00 29 0.847 P10275 G214R Disease NA 0.347 0.00 2 0.535 P10275 G491S Disease NA 0.325 0.38 -13 0.217 P10275 G568W Disease 0.965 0.785 0.00 65 0.936 P10275 G688E Disease 0.921 0.638 0.10 49 0.912 P10275 G708A Disease 0.434 0.118 0.49 23 0.153 P10275 G708V Disease 0.659 0.571 0.03 41 0.782 P10275 G724D Disease 0.919 0.882 0.04 45 0.915 P10275 G743E Disease 0.516 0.324 1.00 58 0.488 P10275 G743V Disease 0.529 0.767 0.40 37 0.844 P10275 G750D Disease 0.843 0.630 0.01 59 0.905 P10275 G820A Disease 0.824 0.918 0.01 32 0.869 P10275 G909R Disease 0.924 0.955 0.00 51 0.926 P10275 H874R Disease 0.713 0.712 0.63 27 0.831 P10275 H917R Disease 0.843 0.957 0.01 40 0.889 P10275 I664N Disease NA 0.455 0.79 31 0.309 P10275 I737T Disease 0.643 0.567 0.00 28 0.766 P10275 I841S Disease 0.415 0.256 0.21 34 0.230 P10275 I842T Disease 0.664 0.718 0.07 38 0.791 P10275 I869M Disease 0.375 0.472 0.13 18 0.393 P10275 I898T Disease 0.518 0.902 0.01 27 0.843 P10275 L255P Disease NA 0.758 0.02 -35 0.681 P10275 L547F Disease NA 0.246 0.68 2 0.189 P10275 L616P Disease 0.890 0.886 0.00 68 0.928 P10275 L616R Disease 0.854 0.728 0.00 68 0.921 P10275 L677P Disease 0.749 0.908 0.01 31 0.841 P10275 L700M Disease 0.635 0.324 0.14 3 0.562 P10275 L701F Disease 0.660 0.611 0.08 11 0.761 P10275 L701H Disease 0.916 0.689 0.01 45 0.850 P10275 L707R Disease 0.922 0.916 0.00 53 0.932 P10275 L712F Disease 0.660 0.895 0.07 17 0.853 P10275 L722F Disease 0.660 0.889 0.11 19 0.858 P10275 L728S Disease 0.991 0.959 0.00 38 0.943 P10275 L744F Disease 0.567 0.858 0.06 21 0.850 P10275 L762F Disease 0.763 0.906 0.05 28 0.793 P10275 L768P Disease 0.936 0.934 0.02 36 0.904 P10275 L790F Disease 0.505 0.385 0.34 14 0.530 P10275 L812F Disease 0.538 0.878 0.06 33 0.645 P10275 L821V Disease 0.673 0.639 0.04 28 0.780 P10275 L863R Disease 0.792 0.972 0.00 58 0.937 P10275 L881V Disease 0.207 0.302 0.15 21 0.326 P10275 L907F Disease 0.610 0.586 0.02 30 0.754 P10275 M742I Disease 0.698 0.845 0.06 14 0.792 P10275 M742V Disease 0.717 0.830 0.07 20 0.831 P10275 M745T Disease 0.726 0.820 0.01 32 0.821 P10275 M749V Disease 0.269 0.684 0.09 30 0.454 P10275 M780I Disease 0.230 0.276 0.13 29 0.351 P10275 M787V Disease 0.340 0.331 0.05 22 0.372 P10275 M807R Disease 0.879 0.879 0.00 50 0.923 P10275 M807T Disease 0.834 0.631 0.00 36 0.809 P10275 M807V Disease 0.685 0.633 0.06 23 0.783 P10275 M886V Disease 0.218 0.163 0.33 22 0.188 P10275 M895T Disease 0.556 0.477 0.00 20 0.697 P10275 N610T Disease 0.848 0.129 0.04 44 0.467 P10275 N705S Disease 0.802 0.283 0.15 24 0.570 P10275 N705Y Disease 0.927 0.422 0.10 49 0.624 P10275 N727K Disease 0.836 0.327 0.08 25 0.590 P10275 N756S Disease 0.342 0.139 0.13 22 0.237 P10275 N758T Disease 0.420 0.191 0.05 16 0.309 P10275 N771H Disease 0.841 0.367 0.13 31 0.580 P10275 P390R Disease NA 0.540 0.00 34 0.736 P10275 P390S Disease NA 0.475 0.01 -15 0.309 P10275 P548S Disease NA 0.577 0.34 25 0.459 P10275 P671H Disease 0.754 0.643 0.00 40 0.806 P10275 P682T Disease 0.911 0.864 0.02 33 0.834 P10275 P723S Disease 0.794 0.895 0.02 43 0.872 P10275 P766S Disease 0.883 0.527 0.08 46 0.863 P10275 P892L Disease 0.916 0.805 0.14 30 0.845 P10275 P904H Disease 0.954 0.908 0.00 51 0.953 P10275 P904S Disease 0.857 0.930 0.02 35 0.881 P10275 P913S Disease 0.743 0.815 0.01 34 0.730 P10275 Q194R Disease NA 0.354 0.16 13 0.237 P10275 Q443R Disease NA 0.549 0.39 39 0.738 P10275 Q711E Disease 0.795 0.390 0.25 36 0.583 P10275 Q733H Disease 0.993 0.859 0.00 44 0.934 P10275 Q798E Disease 0.772 0.406 0.09 2 0.588 P10275 R585K Disease 0.967 0.893 0.00 34 0.942 P10275 R607Q Disease 0.986 0.386 0.12 41 0.604 P10275 R608K Disease 0.676 0.828 0.01 29 0.849 P10275 R615H Disease 0.681 0.855 0.00 67 0.916 P10275 R615P Disease 0.799 0.941 0.00 79 0.944 P10275 R617P Disease 0.762 0.938 0.00 65 0.942 P10275 R710T Disease 0.794 0.590 0.02 44 0.787 P10275 R752Q Disease 0.835 0.869 0.01 49 0.913 P10275 R774C Disease 0.895 0.594 0.03 45 0.875 P10275 R774H Disease 0.520 0.160 0.03 24 0.296 P10275 R779W Disease 0.813 0.325 0.22 52 0.617 P10275 R788S Disease 0.356 0.158 0.49 31 0.233 P10275 R831L Disease 0.874 0.905 0.09 32 0.832 P10275 R831Q Disease 0.820 0.850 0.36 23 0.785 P10275 R840C Disease 0.845 0.688 0.01 38 0.786 P10275 R840G Disease 0.585 0.598 0.09 33 0.782 P10275 R840H Disease 0.532 0.470 0.12 16 0.540 P10275 R840S Disease 0.464 0.430 0.22 26 0.386 P10275 R854K Disease 0.149 0.197 0.20 15 0.246 P10275 R855C Disease 0.958 0.829 0.00 61 0.940 P10275 R855H Disease 0.901 0.788 0.02 44 0.891 P10275 R871G Disease 0.521 0.458 0.27 32 0.473 P10275 S205R Polymorphism NA 0.221 0.00 30 0.381 P10275 S597G Disease 0.100 0.074 0.68 26 0.085 P10275 S702A Disease 0.293 0.244 0.12 0 0.269 P10275 S703C Disease 0.838 0.659 0.01 24 0.789 P10275 S703G Disease 0.626 0.469 0.13 17 0.568 P10275 S759F Disease NA 0.646 0.01 36 0.799 P10275 S814N Disease 0.089 0.414 0.58 27 0.234 P10275 S865P Disease 0.643 0.936 0.03 51 0.855 P10275 V581F Disease 0.846 0.859 0.03 49 0.912 P10275 V684I Disease 0.357 0.164 0.10 0 0.200 P10275 V746M Disease 0.651 0.218 0.24 16 0.486 P10275 V866E Disease 0.662 0.575 0.00 47 0.831 P10275 V866L Disease 0.091 0.095 1.00 10 0.088 P10275 V866M Disease 0.151 0.162 0.21 9 0.130 P10275 V889M Disease 0.693 0.716 0.01 24 0.837 P10275 V903M Disease 0.419 0.313 0.00 1 0.481 P10275 V911L Disease 0.402 0.522 0.01 0 0.483 P10275 W741R Disease 0.941 0.918 0.02 63 0.941 P10275 W751R Disease 0.940 0.797 0.08 64 0.936 P10275 Y571C Disease 0.955 0.891 0.00 68 0.941 P10275 Y763C Disease 0.919 0.697 0.20 50 0.892 P10275 Y763H Disease 0.758 0.528 0.12 48 0.773 P10275 Y834C Disease 0.953 0.876 0.00 47 0.916 P10314 R89G Polymorphism 0.477 0.816 0.06 18 0.632 P10314 I166T Polymorphism 0.408 0.757 0.43 7 0.622 P10314 L180Q Polymorphism 0.221 0.444 0.47 -33 0.223 P10314 M121I Polymorphism 0.221 0.659 0.45 13 0.275 P10314 N151K Polymorphism 0.576 0.953 0.03 41 0.764 P10314 P129S Polymorphism 0.261 0.760 0.71 -27 0.497 P10314 Q138R Polymorphism 0.243 0.488 0.68 -5 0.195 P10314 S101N Polymorphism 0.295 0.113 1.00 -28 0.138 P10314 V176E Polymorphism 0.244 0.367 0.56 2 0.337 P10316 D101N Polymorphism 0.347 0.242 1.00 -36 0.235 P10319 G86E Polymorphism 0.358 0.460 0.13 -23 0.181 P10319 L187T Polymorphism 0.350 0.173 0.53 -34 0.137 P10319 V176A Polymorphism 0.209 0.100 0.56 -27 0.173 P10321 A73E Polymorphism 0.554 0.582 0.07 22 0.615 P10321 E43K Polymorphism 0.440 0.829 0.11 30 0.665 P10321 K90N Polymorphism 0.213 0.288 0.48 -25 0.199 P10321 L10I Polymorphism 0.300 0.671 0.13 -57 0.480 P10321 V76M Polymorphism 0.313 0.155 0.51 -48 0.163 P10321 A182V Polymorphism 0.530 0.295 0.02 6 0.554 P10321 A330V Polymorphism 0.182 0.411 0.57 -40 0.236 P10321 E201K Polymorphism 0.396 0.347 0.67 17 0.356 P10321 L171W Polymorphism 0.452 0.241 1.00 -39 0.215 P10321 M331K Polymorphism 0.400 0.684 0.02 -1 0.460 P10321 T363A Polymorphism 0.169 0.076 1.00 -21 0.056 P10321 V272M Polymorphism 0.800 0.418 0.05 33 0.616 P10321 V328I Polymorphism 0.394 0.336 0.16 -27 0.345 P10321 Y137H Polymorphism 0.504 0.937 0.13 41 0.758 P10323 F166L Polymorphism NA 0.542 0.73 -8 0.166 P10323 L120V Polymorphism 0.218 0.096 0.49 -26 0.149 P10398 M98T Polymorphism NA 0.171 1.00 -7 0.093 P10398 E578D Polymorphism 0.289 0.151 0.31 -5 0.243 P10415 T7S Polymorphism 0.205 0.177 0.39 36 0.162 P10415 A43T Polymorphism 0.269 0.110 0.63 -34 0.087 P10451 R301H Polymorphism 0.693 0.095 0.11 27 0.102 P10515 A43V Polymorphism NA 0.073 0.24 -7 0.038 P10515 S98F Polymorphism 0.687 0.243 0.03 23 0.624 P10515 D313V Polymorphism 0.478 0.096 0.26 3 0.223 P10523 R84C Polymorphism 0.859 0.932 0.00 28 0.838 P10523 P364L Polymorphism 0.961 0.816 0.00 29 0.892 P10523 R384C Polymorphism 0.844 0.843 0.00 47 0.888 P10523 T125M Polymorphism 0.427 0.294 0.06 41 0.498 P10523 V403A Polymorphism 0.109 0.041 0.20 -28 0.018 P10523 V403I Polymorphism 0.057 0.032 0.59 -12 0.020 P10586 A412V Polymorphism NA 0.036 1.00 44 0.062 P10586 D562N Polymorphism NA 0.122 0.60 34 0.167 P10600 T60M Polymorphism 0.132 0.119 0.12 -19 0.182 P10619 Q49R Disease 0.350 0.672 0.57 56 0.780 P10619 S90L Disease 0.851 0.918 0.02 48 0.884 P10619 W65R Disease 0.852 0.827 0.01 59 0.820 P10619 F440V Disease 0.533 0.556 0.03 21 0.533 P10619 Y249N Disease 0.224 0.304 0.06 27 0.326 P10619 Y395C Disease 0.949 0.966 0.00 63 0.937 P10632 K399R Polymorphism 0.358 0.322 0.13 -35 0.312 P10635 H94R Polymorphism 0.087 0.245 0.46 -10 0.160 P10635 R28C Polymorphism 0.753 0.827 0.00 47 0.851 P10635 V11M Polymorphism 0.252 0.475 0.19 -7 0.414 P10635 A237S Polymorphism 0.289 0.280 0.42 -52 0.180 P10635 E418K Polymorphism 0.676 0.649 0.09 18 0.676 P10635 G169R Polymorphism 0.684 0.889 0.00 48 0.827 P10635 G212E Polymorphism 0.118 0.729 0.27 19 0.594 P10635 I369T Polymorphism 0.662 0.404 0.00 13 0.617 P10635 P469A Polymorphism NA 0.559 0.05 4 0.493 P10635 R343G Polymorphism 0.680 0.868 0.00 49 0.837 P10635 R365H Polymorphism 0.728 0.913 0.00 71 0.734 P10635 S311L Polymorphism 0.471 0.734 0.00 32 0.788 P10635 S486T Polymorphism NA 0.194 0.50 -29 0.224 P10636 R5H Disease NA 0.410 0.00 30 0.252 P10636 R5L Disease NA 0.439 0.00 26 0.517 P10636 E659V Disease 0.133 0.270 0.16 36 0.235 P10636 G589V Disease 0.831 0.929 0.11 39 0.871 P10636 G620V Disease 0.803 0.945 0.01 36 0.876 P10636 K634M Disease 0.555 0.650 0.00 38 0.774 P10636 L583V Disease 0.160 0.508 0.51 11 0.235 P10636 N596K Disease 0.180 0.634 0.39 2 0.512 P10636 N613H Disease 0.876 0.911 0.01 31 0.897 P10636 P618L Disease 0.684 0.842 0.01 32 0.867 P10636 P618S Disease 0.429 0.826 0.03 36 0.807 P10636 R370W Polymorphism NA 0.190 0.02 43 0.378 P10636 S447P Polymorphism NA 0.032 1.00 9 0.057 P10636 S622N Disease 0.104 0.202 0.33 -21 0.147 P10636 V654M Disease 0.547 0.819 0.01 26 0.819 P10643 C128R Polymorphism NA 0.833 0.86 47 0.732 P10643 E682Q Disease 0.247 0.107 0.08 15 0.198 P10643 G379R Disease NA 0.966 0.00 67 0.939 P10643 K420Q Polymorphism NA 0.550 0.19 32 0.501 P10643 R220Q Disease NA 0.117 0.64 39 0.196 P10643 R521S Disease 0.787 0.892 0.00 34 0.866 P10643 R687H Disease 0.258 0.102 0.16 29 0.109 P10643 T587P Polymorphism 0.063 0.203 0.35 17 0.118 P10644 S9N Disease NA 0.110 0.08 6 0.103 P10644 R74C Disease 0.544 0.518 0.12 26 0.611 P10644 A213D Disease 0.963 0.905 0.00 64 0.953 P10644 D183Y Disease 0.763 0.837 0.00 58 0.911 P10644 G289W Disease 0.938 0.880 0.00 65 0.949 P10644 R146S Disease 0.400 0.515 0.42 17 0.454 P10645 R61Q Polymorphism 0.174 0.259 0.39 -1 0.191 P10645 A274G Polymorphism 0.195 0.075 0.52 1 0.039 P10645 D369N Polymorphism 0.669 0.199 0.00 38 0.499 P10645 E176K Polymorphism 0.391 0.115 0.60 38 0.091 P10645 E264D Polymorphism 0.220 0.072 0.52 26 0.055 P10645 L332P Polymorphism 0.485 0.264 0.30 15 0.176 P10696 L273M Polymorphism 0.139 0.581 0.21 -48 0.143 P10696 L316R Polymorphism 0.299 0.839 0.67 -57 0.508 P10721 C691S Polymorphism 0.143 0.594 0.39 -3 0.141 P10721 E583K Disease 0.990 0.905 0.00 51 0.928 P10721 F584C Disease 0.861 0.678 0.00 57 0.911 P10721 F584L Disease 0.404 0.591 0.19 14 0.455 P10721 G601R Disease 0.966 0.907 0.00 71 0.952 P10721 G664R Disease 0.623 0.857 0.05 38 0.649 P10721 G812V Disease 0.998 0.877 0.00 65 0.946 P10721 K550I Disease 0.950 0.844 0.00 42 0.884 P10721 L656P Disease 0.964 0.941 0.00 68 0.950 P10721 M541L Polymorphism 0.126 0.165 1.00 -40 0.111 P10721 R791G Disease 0.924 0.917 0.00 55 0.946 P10721 R796G Disease 0.989 0.919 0.01 64 0.951 P10721 S715N Polymorphism NA 0.254 0.53 -19 0.284 P10721 T847P Disease 0.692 0.893 0.00 53 0.893 P10721 V532I Polymorphism 0.105 0.140 0.57 -26 0.116 P10721 V559A Disease 0.466 0.314 0.01 11 0.401 P10721 V559D Disease 0.785 0.640 0.00 23 0.765 P10746 L4F Disease 0.362 0.111 0.07 27 0.256 P10746 V3F Disease 0.839 0.500 0.04 15 0.720 P10746 A66V Disease 0.295 0.621 0.35 44 0.441 P10746 A69T Disease 0.396 0.771 0.69 38 0.677 P10746 C73R Disease 0.529 0.614 0.63 38 0.760 P10746 P53L Disease 0.297 0.556 1.00 35 0.400 P10746 S47P Disease 0.469 0.608 0.35 20 0.698 P10746 T62A Disease 0.375 0.883 0.00 66 0.882 P10746 V82F Disease 0.331 0.151 0.08 21 0.284 P10746 V99A Disease 0.712 0.902 0.02 63 0.912 P10746 Y19C Disease 0.953 0.956 0.01 54 0.961 P10746 A104V Disease 0.464 0.572 0.16 26 0.736 P10746 G188R Disease 0.128 0.599 0.10 21 0.244 P10746 G188W Disease 0.861 0.637 0.01 46 0.816 P10746 G225S Disease 0.868 0.880 0.00 70 0.943 P10746 I129T Disease 0.839 0.940 0.00 47 0.896 P10746 I219S Disease 0.268 0.652 0.06 42 0.659 P10746 S212P Disease 0.266 0.610 0.17 -11 0.359 P10746 T228M Disease 0.933 0.843 0.00 62 0.942 P10767 A63V Polymorphism NA 0.127 0.16 -8 0.221 P10767 R191W Polymorphism 0.855 0.657 0.00 33 0.829 P10768 G190E Polymorphism 0.341 0.865 0.47 35 0.643 P10768 G257D Polymorphism 0.217 0.957 0.01 42 0.587 P10809 D29G Disease 0.655 0.453 0.00 27 0.666 P10809 V98I Disease 0.252 0.608 0.02 -16 0.475 P10828 A234T Disease 0.394 0.078 0.12 -1 0.171 P10828 A268G Disease 0.423 0.295 0.39 -1 0.307 P10828 A317T Disease 0.394 0.251 0.43 -12 0.259 P10828 A335P Disease 0.597 0.677 0.01 8 0.516 P10828 C446R Disease 0.524 0.536 0.02 33 0.598 P10828 F459C Disease 0.657 0.610 0.00 16 0.782 P10828 G332R Disease 0.720 0.718 0.03 64 0.900 P10828 G345R Disease 0.720 0.951 0.00 52 0.866 P10828 G345S Disease 0.522 0.920 0.00 16 0.575 P10828 G345V Disease 0.692 0.930 0.00 34 0.847 P10828 G347E Disease 0.947 0.948 0.09 23 0.919 P10828 I431M Disease 0.347 0.407 0.07 18 0.412 P10828 K342I Disease 0.649 0.526 0.03 13 0.651 P10828 K443E Disease 0.805 0.609 0.00 49 0.842 P10828 L341P Disease 0.767 0.890 0.01 22 0.726 P10828 L346F Disease 0.453 0.485 0.38 -18 0.332 P10828 M442V Disease 0.177 0.312 0.01 6 0.174 P10828 N331D Disease 0.293 0.120 0.15 29 0.293 P10828 P447T Disease 0.906 0.606 0.01 0 0.773 P10828 P453H Disease 0.961 0.722 0.00 37 0.884 P10828 P453L Disease 0.927 0.701 0.00 24 0.868 P10828 P453S Disease 0.876 0.711 0.00 35 0.866 P10828 P453T Disease 0.902 0.800 0.00 8 0.875 P10828 Q340H Disease 0.943 0.747 0.03 12 0.843 P10828 R243W Disease NA 0.595 0.03 48 0.798 P10828 R316H Disease 0.939 0.680 0.00 58 0.909 P10828 R320C Disease 0.973 0.914 0.00 64 0.980 P10828 R320H Disease 0.939 0.742 0.00 44 0.896 P10828 R338W Disease 0.980 0.940 0.00 56 0.948 P10828 R429Q Disease 0.319 0.893 0.00 46 0.737 P10828 R438H Disease 0.509 0.474 0.02 -19 0.582 P10828 T426I Disease 0.315 0.463 0.01 8 0.496 P10828 V348E Disease 0.659 0.682 1.00 -14 0.606 P10909 D328N Polymorphism 0.140 0.060 0.89 -35 0.070 P10912 C56S Disease 0.996 0.904 0.00 40 0.943 P10912 E62K Disease 0.548 0.876 0.09 24 0.843 P10912 R89K Disease NA 0.228 0.55 28 0.277 P10912 S58L Disease 0.951 0.843 0.00 42 0.895 P10912 W68R Disease 0.978 0.900 0.00 69 0.965 P10912 C440F Disease 0.084 0.593 0.10 23 0.243 P10912 D170H Disease 0.788 0.869 0.52 52 0.856 P10912 D262N Disease NA 0.179 0.37 35 0.263 P10912 E465K Polymorphism 0.397 0.805 0.15 23 0.596 P10912 F114S Disease 0.960 0.946 0.00 55 0.967 P10912 I171T Disease 0.608 0.555 0.01 45 0.786 P10912 P149Q Disease 0.835 0.940 0.01 41 0.886 P10912 P495T Polymorphism 0.502 0.897 0.04 23 0.804 P10912 Q172P Disease 0.596 0.690 0.21 35 0.720 P10912 R179C Disease 0.466 0.534 0.03 36 0.740 P10912 R179H Polymorphism 0.327 0.316 0.05 25 0.133 P10912 R229G Disease 0.698 0.628 0.02 38 0.766 P10912 S244I Disease 0.728 0.949 0.00 50 0.898 P10912 V143A Disease 0.485 0.774 0.01 55 0.855 P10912 V162D Disease NA 0.528 0.63 48 0.468 P10912 V162F Polymorphism NA 0.589 0.06 46 0.705 P10912 V173G Disease 0.735 0.888 0.00 41 0.867 P10912 Y226C Disease 0.828 0.816 0.00 63 0.932 P10916 A13T Disease NA 0.500 0.08 7 0.470 P10916 E22K Disease NA 0.533 0.42 11 0.520 P10916 F18L Disease NA 0.901 0.81 22 0.631 P10916 G57R Polymorphism 0.258 0.949 0.00 39 0.748 P10916 P95A Disease 0.642 0.484 0.29 20 0.636 P10916 R58Q Disease 0.296 0.260 0.87 10 0.262 P10916 D166V Disease 0.574 0.374 0.01 35 0.631 P10997 S53G Polymorphism 0.369 0.379 1.00 5 0.257 P11021 N543H Polymorphism 0.297 0.269 0.02 -40 0.339 P11055 D517Y Disease 0.950 0.953 0.00 63 0.939 P11055 E375K Disease 0.618 0.160 0.03 4 0.353 P11055 E498G Disease 0.954 0.879 0.00 56 0.929 P11055 G769V Disease 0.932 0.858 0.00 52 0.924 P11055 K838E Disease 0.673 0.792 0.00 56 0.900 P11055 R672C Disease 0.960 0.904 0.02 66 0.947 P11055 R672H Disease 0.907 0.736 0.00 66 0.924 P11055 S261F Disease 0.884 0.932 0.02 39 0.896 P11055 S292C Disease 0.833 0.511 0.00 -4 0.764 P11055 T178I Disease 0.972 0.737 0.00 47 0.917 P11055 V825D Disease 0.878 0.733 0.00 50 0.896 P11055 Y583S Disease 0.892 0.936 0.00 55 0.928 P11055 A1003V Polymorphism 0.227 0.417 0.31 16 0.337 P11055 A1192T Polymorphism 0.166 0.263 0.56 -53 0.208 P11055 A1637V Disease NA 0.475 0.19 -9 0.345 P11055 D1622A Disease 0.771 0.766 0.00 11 0.846 P11055 R1137C Polymorphism 0.905 0.752 0.00 24 0.850 P11055 T1313I Polymorphism 0.510 0.172 0.39 -46 0.141 P11086 T98A Polymorphism 0.264 0.248 0.28 28 0.324 P11086 L211H Polymorphism 0.766 0.962 0.00 52 0.927 P11086 R112C Polymorphism 0.446 0.322 0.02 21 0.483 P11086 R254H Polymorphism 0.381 0.237 0.12 18 0.360 P11086 S188C Polymorphism 0.643 0.145 1.00 -28 0.111 P11086 W276R Polymorphism 0.099 0.336 0.40 34 0.359 P11117 R29Q Polymorphism NA 0.093 1.00 -65 0.097 P11117 S320F Polymorphism 0.416 0.642 0.03 15 0.703 P11117 V402I Polymorphism 0.073 0.089 0.50 -27 0.069 P11137 A82G Polymorphism 0.407 0.174 0.00 5 0.158 P11137 E179G Polymorphism 0.482 0.105 0.01 25 0.147 P11137 G991R Polymorphism 0.129 0.207 0.00 35 0.274 P11137 H976L Polymorphism 0.534 0.156 0.00 28 0.232 P11137 R423K Polymorphism 0.071 0.018 1.00 -54 0.027 P11137 M1099V Polymorphism NA 0.020 1.00 -29 0.022 P11150 N215S Polymorphism 0.228 0.537 0.13 -28 0.154 P11150 S289F Disease 0.924 0.948 0.00 51 0.934 P11150 T405M Disease 0.677 0.313 0.04 32 0.600 P11150 V342I Polymorphism 0.084 0.080 0.69 5 0.122 P11161 D355V Disease 0.989 0.217 0.02 41 0.533 P11161 D383Y Disease 0.991 0.217 0.02 48 0.563 P11161 I268N Disease 0.935 0.734 0.24 52 0.924 P11161 R359W Disease 0.994 0.194 0.00 49 0.641 P11161 R381C Disease 0.992 0.188 0.07 47 0.551 P11161 R381H Disease 0.985 0.171 0.20 34 0.323 P11161 R409W Disease 0.994 0.187 0.10 49 0.607 P11166 A275T Disease 0.340 0.208 0.40 -2 0.345 P11166 G314S Disease 0.976 0.908 0.08 20 0.887 P11168 P68L Polymorphism NA 0.430 0.39 -30 0.298 P11168 L389P Disease NA 0.897 0.25 9 0.703 P11168 P417L Disease NA 0.883 0.03 31 0.860 P11168 T110I Polymorphism 0.084 0.636 0.75 -62 0.089 P11168 V423E Disease NA 0.525 0.21 48 0.789 P11169 V85L Polymorphism 0.167 0.583 0.72 -6 0.204 P11172 R96G Disease NA 0.723 0.27 27 0.798 P11172 S30G Polymorphism NA 0.841 0.09 60 0.898 P11172 G213A Polymorphism NA 0.286 0.36 -23 0.242 P11172 G429R Disease NA 0.783 0.00 55 0.843 P11172 V109G Disease NA 0.664 0.00 6 0.605 P11177 L31V Polymorphism NA 0.129 0.30 -50 0.113 P11177 P344S Disease 0.575 0.866 0.06 47 0.876 P11177 Y132C Disease 0.732 0.918 0.00 64 0.888 P11182 I98M Disease 0.500 0.293 0.02 29 0.417 P11182 F276C Disease 0.943 0.459 0.08 34 0.688 P11182 G384S Disease 0.263 0.813 0.04 5 0.446 P11215 A858V Polymorphism 0.249 0.198 0.19 -7 0.203 P11216 A303S Polymorphism 0.627 0.846 0.08 29 0.575 P11216 D502N Polymorphism 0.400 0.651 0.37 -54 0.369 P11217 A660D Disease 0.932 0.909 0.00 53 0.926 P11217 A687P Disease 0.826 0.949 0.03 29 0.875 P11217 A704V Disease 0.214 0.484 1.00 -40 0.174 P11217 E349K Disease 0.795 0.920 0.00 64 0.917 P11217 E655K Disease 0.499 0.892 0.01 35 0.865 P11217 G205S Disease 0.713 0.894 0.00 47 0.816 P11217 G686R Disease 0.983 0.944 0.03 69 0.938 P11217 K543T Disease 0.560 0.865 0.00 46 0.817 P11217 L116P Disease 0.499 0.916 0.01 50 0.898 P11217 L292P Disease 0.863 0.952 0.00 38 0.833 P11217 L397P Disease 0.950 0.955 0.00 60 0.937 P11217 N685Y Disease 0.979 0.914 0.00 59 0.941 P11217 Q666E Disease 0.577 0.899 0.03 43 0.867 P11217 R194W Disease 0.951 0.904 0.00 58 0.932 P11217 R602W Disease 0.913 0.929 0.00 42 0.880 P11217 T488N Disease 0.683 0.895 0.01 48 0.806 P11217 W798R Disease 0.982 0.957 0.00 64 0.939 P11226 G54D Polymorphism 0.935 0.835 0.00 71 0.945 P11226 G57E Polymorphism 0.938 0.871 0.00 35 0.878 P11226 R52C Polymorphism 0.779 0.746 0.02 33 0.843 P11226 N214Y Polymorphism 0.593 0.922 0.02 18 0.842 P11230 E32G Polymorphism NA 0.405 0.30 9 0.436 P11230 L285M Disease 0.376 0.785 0.00 9 0.701 P11230 V289M Disease 0.912 0.851 0.00 19 0.833 P11245 R64Q Polymorphism 0.725 0.943 0.15 55 0.919 P11245 R64W Polymorphism 0.961 0.983 0.00 65 0.955 P11245 D122N Polymorphism 0.644 0.890 0.00 72 0.917 P11245 G286E Polymorphism 0.155 0.036 0.46 15 0.046 P11245 Q145P Polymorphism 0.725 0.796 0.04 33 0.817 P11245 T193M Polymorphism 0.485 0.214 0.00 56 0.440 P11274 D752E Polymorphism 0.151 0.331 0.11 -7 0.219 P11274 A1149T Polymorphism 0.225 0.500 0.19 -17 0.307 P11274 A1204G Polymorphism NA 0.837 0.06 34 0.585 P11274 D1106N Polymorphism 0.384 0.807 0.13 12 0.543 P11274 E1037K Polymorphism NA 0.298 0.10 34 0.358 P11274 E1161K Polymorphism NA 0.372 0.34 27 0.323 P11274 K1187E Polymorphism NA 0.756 0.04 29 0.632 P11274 T1096A Polymorphism 0.330 0.319 0.21 9 0.234 P11274 V1091M Polymorphism 0.628 0.689 0.01 39 0.632 P11274 W1235R Polymorphism NA 0.464 0.02 64 0.619 P11277 S439N Polymorphism 0.177 0.175 0.98 -22 0.115 P11277 S613I Polymorphism 0.382 0.192 0.22 -14 0.366 P11277 A2018G Disease 0.801 0.466 0.15 17 0.683 P11277 A2023V Disease 0.674 0.345 0.05 21 0.619 P11277 A2053P Disease 0.835 0.661 0.13 46 0.846 P11277 G1408R Polymorphism 0.641 0.642 0.00 45 0.833 P11277 H1374R Polymorphism NA 0.228 0.56 -4 0.139 P11277 L2025R Disease 0.953 0.856 0.00 46 0.896 P11277 R1403Q Polymorphism 0.330 0.134 0.72 -4 0.129 P11277 S2019P Disease 0.613 0.747 0.28 -9 0.750 P11277 W2024R Disease 0.923 0.965 0.02 50 0.927 P11309 E215Q Polymorphism 0.324 0.164 0.40 -13 0.246 P11309 E233D Polymorphism 0.253 0.195 0.76 -47 0.184 P11310 I78T Disease NA 0.240 0.04 -13 0.417 P11310 R53C Disease NA 0.847 0.01 46 0.878 P11310 Y67H Disease NA 0.185 0.48 8 0.226 P11310 C116Y Disease 0.762 0.944 1.00 39 0.784 P11310 C244R Disease 0.526 0.757 0.15 62 0.690 P11310 G195R Disease 0.915 0.931 0.04 73 0.914 P11310 G267R Disease 0.921 0.955 0.00 78 0.816 P11310 G310R Disease 0.858 0.915 0.01 70 0.914 P11310 I375T Disease 0.827 0.662 0.16 21 0.658 P11310 K329E Disease 0.394 0.450 1.00 -10 0.263 P11310 M149I Disease 0.365 0.371 0.17 9 0.295 P11310 M326T Disease 0.874 0.913 0.31 44 0.866 P11310 R206L Disease 0.826 0.500 0.26 28 0.627 P11310 R281T Disease 0.988 0.898 0.00 72 0.865 P11310 S245L Disease 0.756 0.831 0.03 44 0.797 P11310 S336R Disease 0.640 0.710 0.02 41 0.811 P11310 T121I Disease 0.492 0.401 0.38 11 0.368 P11310 T193A Disease 0.865 0.833 0.04 60 0.826 P11310 Y352C Disease 0.681 0.596 0.18 9 0.745 P11362 G48S Disease 0.047 0.864 0.00 38 0.649 P11362 G97D Disease 0.379 0.800 0.00 63 0.860 P11362 N77K Polymorphism 0.120 0.336 0.81 36 0.380 P11362 R22S Polymorphism 0.059 0.409 0.37 2 0.216 P11362 R78C Disease 0.616 0.891 0.01 57 0.895 P11362 Y99C Disease 0.689 0.833 0.00 68 0.906 P11362 A167S Disease 0.666 0.747 0.07 13 0.794 P11362 A343V Disease 0.346 0.691 0.01 32 0.544 P11362 A520T Disease 0.587 0.651 0.13 20 0.514 P11362 C101F Disease 0.482 0.885 0.00 50 0.873 P11362 C178S Disease 0.845 0.929 0.00 63 0.937 P11362 C277Y Disease 0.953 0.988 0.00 68 0.945 P11362 C381R Disease 0.455 0.811 0.40 40 0.813 P11362 D129A Disease 0.374 0.222 0.56 36 0.394 P11362 D224H Disease 0.916 0.941 0.00 62 0.966 P11362 E274G Disease 0.678 0.671 0.11 35 0.813 P11362 G237D Disease 0.913 0.935 0.00 71 0.937 P11362 G270D Disease 0.842 0.839 0.02 72 0.918 P11362 G687R Disease 0.844 0.889 0.00 73 0.925 P11362 G703R Disease 0.841 0.898 0.01 33 0.865 P11362 G703S Disease 0.601 0.847 0.18 -17 0.520 P11362 G818R Polymorphism NA 0.126 0.34 33 0.128 P11362 H621R Disease 0.847 0.892 0.00 67 0.924 P11362 I300T Disease NA 0.347 0.32 25 0.413 P11362 I538V Disease 0.286 0.241 0.19 6 0.342 P11362 I693F Disease 0.774 0.792 0.00 22 0.839 P11362 L245P Disease 0.935 0.968 0.00 52 0.931 P11362 L769V Polymorphism 0.636 0.291 0.08 18 0.597 P11362 M719R Disease 0.854 0.917 0.00 60 0.928 P11362 N330I Disease 0.922 0.751 0.00 42 0.841 P11362 N724K Disease 0.387 0.596 0.27 7 0.453 P11362 P252R Disease 0.788 0.750 0.25 28 0.745 P11362 P283R Disease 0.604 0.711 0.04 44 0.732 P11362 P722H Disease 0.951 0.894 0.00 61 0.936 P11362 P722S Disease 0.848 0.854 0.00 53 0.916 P11362 P745S Disease 0.851 0.875 0.00 50 0.916 P11362 P772S Disease 0.317 0.697 0.09 10 0.529 P11362 R250W Disease 0.969 0.956 0.00 62 0.943 P11362 R254Q Disease 0.824 0.516 0.06 51 0.850 P11362 R622G Disease 0.853 0.910 0.00 65 0.754 P11362 R622Q Disease 0.803 0.911 0.00 69 0.926 P11362 R822C Polymorphism NA 0.543 0.00 52 0.734 P11362 S332C Disease 0.743 0.429 0.01 34 0.657 P11362 S346C Disease 0.838 0.421 0.02 29 0.652 P11362 S685F Disease 0.902 0.905 0.00 54 0.923 P11362 V102I Disease 0.230 0.091 0.54 4 0.146 P11362 V273M Disease 0.761 0.320 0.03 52 0.652 P11362 V607M Disease 0.676 0.767 0.00 16 0.841 P11362 V795I Disease 0.336 0.288 0.12 26 0.336 P11362 W213G Polymorphism 0.905 0.924 0.01 74 0.927 P11362 W666R Disease 0.926 0.920 0.00 75 0.932 P11362 Y339C Disease 0.928 0.869 0.00 67 0.934 P11362 Y374C Disease 0.850 0.626 0.08 41 0.818 P11387 G214S Polymorphism 0.168 0.767 0.11 -25 0.334 P11388 A1515S Polymorphism NA 0.208 0.33 16 0.117 P11388 G1386D Polymorphism 0.222 0.038 0.65 -17 0.041 P11388 T1324K Polymorphism 0.187 0.114 0.93 -10 0.065 P11413 G410D Disease 0.699 0.845 0.01 52 0.824 P11413 N126D Polymorphism 0.273 0.188 0.60 -51 0.155 P11413 R198P Disease 0.958 0.961 0.00 69 0.940 P11413 R387C Disease 0.916 0.708 0.02 -1 0.774 P11413 R439P Disease 0.848 0.973 0.03 55 0.926 P11413 V394L Disease 0.294 0.188 0.35 -26 0.226 P11464 E41Q Polymorphism 0.057 0.252 0.63 -29 0.100 P11464 T43P Polymorphism 0.057 0.462 0.38 -35 0.077 P11464 E197K Polymorphism 0.087 0.586 0.91 0 0.034 P11464 I125V Polymorphism 0.084 0.481 0.26 10 0.117 P11464 T198N Polymorphism 0.132 0.410 0.99 -11 0.181 P11464 V134E Polymorphism 0.091 0.704 0.90 -9 0.113 P11465 V20L Polymorphism 0.272 0.234 1.00 -56 0.156 P11465 Q179L Polymorphism 0.233 0.236 1.00 3 0.193 P11465 T176A Polymorphism 0.213 0.371 0.90 0 0.266 P11465 T335R Polymorphism NA 0.559 0.01 33 0.719 P11473 L230V Polymorphism 0.204 0.130 0.37 -5 0.181 P11473 T362I Polymorphism 0.086 0.335 0.16 2 0.230 P11488 G38D Disease 0.690 0.852 0.00 58 0.904 P11498 A610T Disease 0.656 0.864 0.00 65 0.914 P11498 M743I Disease 0.575 0.759 0.00 68 0.907 P11498 R156Q Disease 0.528 0.846 0.03 38 0.866 P11498 R270W Disease 0.995 0.930 0.00 70 0.945 P11498 R451C Disease 0.937 0.806 0.03 42 0.860 P11498 R583L Disease 0.822 0.956 0.01 45 0.895 P11498 R631Q Disease 0.760 0.888 0.01 53 0.911 P11498 V145A Disease 0.294 0.207 0.65 -7 0.242 P11498 Y304C Disease 0.992 0.921 0.00 66 0.941 P11509 G5R Polymorphism 0.193 0.662 0.07 51 0.581 P11509 S29N Polymorphism 0.178 0.078 0.49 9 0.143 P11509 E419D Polymorphism 0.091 0.530 0.37 -33 0.069 P11509 F118L Polymorphism 0.133 0.705 0.08 13 0.260 P11509 G479V Polymorphism NA 0.692 0.00 39 0.692 P11509 I471T Polymorphism NA 0.208 0.00 3 0.372 P11509 K194E Polymorphism 0.197 0.391 0.83 -21 0.154 P11509 R203S Polymorphism 0.121 0.182 0.41 -29 0.117 P11509 R485L Polymorphism NA 0.440 0.01 11 0.320 P11509 S131A Polymorphism 0.240 0.128 0.19 -45 0.195 P11509 S224P Polymorphism 0.102 0.346 1.00 -18 0.143 P11509 T294S Polymorphism 0.236 0.161 0.29 -39 0.190 P11509 V110L Polymorphism 0.122 0.422 0.55 -13 0.225 P11509 V292M Polymorphism 0.330 0.353 0.29 -33 0.306 P11509 V365M Polymorphism 0.131 0.445 0.08 -10 0.309 P11511 W39R Polymorphism 0.106 0.792 0.13 59 0.329 P11511 C437Y Disease 0.999 0.964 0.00 76 0.952 P11511 R264C Polymorphism 0.278 0.799 0.07 29 0.563 P11511 R365Q Disease 0.708 0.889 0.01 68 0.923 P11511 R375C Disease 0.926 0.881 0.00 62 0.929 P11511 R435C Disease 0.918 0.919 0.00 73 0.938 P11532 K18N Disease 0.898 0.639 0.04 24 0.801 P11532 L54R Disease 0.949 0.911 0.02 41 0.904 P11532 A168D Disease 0.924 0.891 0.00 59 0.925 P11532 A171P Disease 0.853 0.943 0.25 57 0.928 P11532 A573V Polymorphism 0.450 0.193 0.26 6 0.275 P11532 A784G Polymorphism 0.438 0.446 0.44 36 0.338 P11532 D645G Disease 0.507 0.423 0.03 26 0.581 P11532 K773E Disease 0.276 0.332 0.09 25 0.318 P11532 Q133P Polymorphism 0.939 0.793 0.03 32 0.815 P11532 Q365H Polymorphism 0.853 0.539 0.17 61 0.797 P11532 T279A Disease 0.473 0.175 0.45 39 0.143 P11532 T715S Polymorphism 0.252 0.179 0.87 9 0.178 P11532 Y231N Disease 0.999 0.904 0.00 39 0.925 P11532 A3421V Disease NA 0.145 0.14 9 0.095 P11532 C3340Y Disease 0.968 0.982 0.00 62 0.962 P11532 D3335H Disease 0.939 0.864 0.00 67 0.937 P11532 E2910V Polymorphism NA 0.610 0.18 36 0.531 P11532 F3228L Disease 0.254 0.325 0.71 24 0.195 P11532 H2921R Disease NA 0.349 1.00 -7 0.151 P11532 K2366Q Polymorphism 0.115 0.347 0.49 3 0.187 P11532 N1672K Disease 0.314 0.436 0.23 -11 0.253 P11532 N2299T Polymorphism 0.421 0.818 0.34 -15 0.495 P11532 T1136S Polymorphism 0.169 0.368 0.54 -14 0.150 P11532 T1245I Polymorphism 0.563 0.380 0.19 -4 0.534 P11586 P162L Polymorphism 0.131 0.290 0.06 4 0.270 P11586 R293H Polymorphism 0.373 0.821 0.00 10 0.586 P11586 T761M Polymorphism 0.881 0.516 0.01 18 0.786 P11597 A15G Polymorphism NA 0.354 0.14 11 0.483 P11597 A390P Polymorphism 0.661 0.489 0.10 46 0.608 P11597 D459G Disease 0.586 0.468 0.29 50 0.614 P11597 L168P Disease 0.435 0.740 0.37 30 0.747 P11597 R154W Polymorphism 0.731 0.279 0.01 40 0.521 P11597 R299C Disease 0.813 0.126 0.13 50 0.408 P11597 R468Q Polymorphism 0.092 0.022 0.46 25 0.060 P11597 V455M Polymorphism NA 0.068 0.05 5 0.097 P11597 V486M Polymorphism 0.598 0.235 0.00 15 0.470 P11678 I40M Polymorphism NA 0.288 0.24 -61 0.257 P11678 V35I Polymorphism NA 0.080 0.47 -69 0.145 P11678 A249E Polymorphism 0.082 0.472 0.51 0 0.087 P11678 K276R Polymorphism 0.210 0.237 0.67 -23 0.180 P11678 N572Y Polymorphism 0.944 0.869 0.08 44 0.905 P11678 P292L Polymorphism 0.126 0.618 0.08 -13 0.405 P11678 P358L Polymorphism 0.293 0.607 0.03 -8 0.453 P11678 R286H Disease 0.995 0.935 0.00 -15 0.907 P11678 R326P Polymorphism 0.994 0.949 0.00 73 0.958 P11684 R56G Polymorphism 0.324 0.036 0.15 -7 0.046 P11684 T68A Polymorphism 0.225 0.076 0.70 7 0.051 P11686 E66K Disease 0.269 0.304 0.00 30 0.350 P11686 I73T Disease 0.496 0.125 0.01 -21 0.170 P11686 A116D Disease 0.590 0.349 0.00 25 0.440 P11686 L188Q Disease 0.698 0.665 0.00 34 0.770 P11686 N138T Polymorphism 0.095 0.013 1.00 -57 0.010 P11686 R167Q Disease 0.136 0.049 0.41 22 0.027 P11712 D360E Polymorphism 0.331 0.443 0.01 16 0.532 P11712 E272G Polymorphism 0.349 0.457 0.11 12 0.459 P11712 I359L Polymorphism 0.417 0.182 0.32 -28 0.242 P11712 L413P Polymorphism 0.934 0.902 0.00 35 0.916 P11712 P489S Polymorphism NA 0.926 0.00 47 0.887 P11712 R144C Polymorphism 0.827 0.864 0.03 18 0.734 P11712 R335W Polymorphism 0.923 0.947 0.00 45 0.918 P11717 A724T Polymorphism 0.250 0.368 0.00 31 0.175 P11717 D273G Polymorphism 0.350 0.722 0.00 29 0.610 P11717 G231D Polymorphism 0.639 0.880 0.00 66 0.714 P11717 K512Q Polymorphism 0.280 0.184 0.00 38 0.297 P11717 L252V Polymorphism 0.319 0.626 0.00 46 0.599 P11717 L817V Polymorphism 0.319 0.760 0.00 41 0.615 P11717 P203L Polymorphism 0.296 0.212 0.00 34 0.329 P11717 R529Q Polymorphism 0.203 0.152 0.00 49 0.257 P11717 E1254A Polymorphism 0.472 0.479 0.00 19 0.519 P11717 G1860D Polymorphism 0.674 0.683 0.00 51 0.678 P11717 N2020S Polymorphism 0.242 0.329 0.01 19 0.273 P11717 R1335H Polymorphism 0.450 0.246 0.00 14 0.328 P11717 R1832H Polymorphism 0.137 0.378 0.89 20 0.200 P11717 T1184S Polymorphism 0.328 0.787 0.00 36 0.625 P11766 D353E Polymorphism NA 0.360 1.00 -57 0.245 P11766 L163S Polymorphism 0.247 0.192 0.75 -45 0.148 P11766 V309I Polymorphism NA 0.190 0.28 -22 0.254 P11802 N41S Disease 0.083 0.404 0.81 -43 0.149 P11802 R24C Disease 0.878 0.854 0.04 39 0.874 P11802 R24H Disease 0.718 0.830 0.08 25 0.780 P11802 R82Q Polymorphism NA 0.145 0.35 31 0.196 P11802 R122H Polymorphism 0.371 0.247 0.27 -16 0.220 P12018 S122L Polymorphism 0.045 0.204 0.10 29 0.210 P12034 M54V Polymorphism NA 0.212 0.58 25 0.108 P12035 E509K Disease 0.895 0.745 0.00 43 0.853 P12035 R503P Disease 0.959 0.942 0.00 60 0.940 P12107 W8G Polymorphism NA 0.506 NA 15 0.667 P12107 G625V Disease 0.994 0.736 NA 53 0.967 P12107 G676R Disease 0.988 0.851 NA 67 0.990 P12107 G1516V Disease 0.996 0.644 NA 60 0.945 P12107 L1805F Polymorphism NA 0.773 NA 7 0.648 P12107 P1323L Polymorphism NA 0.427 NA 17 0.428 P12107 S1535P Polymorphism NA 0.351 NA -35 0.215 P12109 G272D Disease 0.615 0.830 0.00 46 0.915 P12109 G275R Disease 0.690 0.809 0.00 56 0.968 P12109 G281R Disease 0.878 0.411 0.00 70 0.815 P12109 G284R Disease 0.997 0.430 0.00 72 0.858 P12109 G290R Disease 0.999 0.647 0.00 70 0.850 P12109 G305V Disease 0.870 0.247 0.00 59 0.653 P12109 G341D Disease 0.998 0.287 0.00 67 0.964 P12109 G341V Disease 0.999 0.243 0.00 55 0.887 P12109 K121R Disease NA 0.119 0.74 24 0.088 P12109 K571T Disease 0.732 0.239 0.13 -11 0.506 P12109 P274L Disease 0.638 0.198 0.51 0 0.417 P12109 R439Q Polymorphism 0.446 0.221 0.60 14 0.249 P12109 R850H Polymorphism NA 0.179 0.24 10 0.256 P12109 S116N Disease NA 0.116 0.55 5 0.089 P12109 S890L Polymorphism NA 0.137 0.37 0 0.094 P12109 T881M Polymorphism NA 0.116 0.11 -13 0.214 P12110 C777R Disease 0.823 0.457 0.09 -2 0.652 P12110 D227N Polymorphism NA 0.475 0.33 49 0.458 P12110 D621N Disease 0.697 0.806 0.00 14 0.825 P12110 E106K Disease 0.222 0.162 0.67 56 0.186 P12110 G271S Disease 0.753 0.818 0.00 63 0.985 P12110 G283R Disease 0.882 0.357 0.00 58 0.668 P12110 G531R Disease 0.998 0.243 0.00 52 0.853 P12110 G700S Disease 0.725 0.462 0.26 59 0.640 P12110 G935R Polymorphism NA 0.227 0.06 71 0.319 P12110 L837P Disease NA 0.943 0.00 36 0.815 P12110 P518S Polymorphism NA 0.677 0.72 0 0.169 P12110 P932L Disease NA 0.150 0.07 26 0.193 P12110 R498H Disease 0.582 0.212 0.13 42 0.464 P12110 R680H Polymorphism 0.163 0.251 0.15 18 0.292 P12110 R784H Disease 0.359 0.103 0.27 8 0.191 P12110 R853Q Disease NA 0.241 0.34 -4 0.239 P12110 R876S Disease NA 0.885 0.00 44 0.805 P12110 S895R Polymorphism NA 0.189 0.73 0 0.304 P12110 V804G Polymorphism 0.511 0.510 0.36 6 0.628 P12110 I1015L Polymorphism NA 0.179 0.67 -19 0.193 P12111 A830S Polymorphism NA 0.243 0.39 33 0.361 P12111 D491H Polymorphism NA 0.730 0.10 44 0.629 P12111 L411V Polymorphism NA 0.235 0.15 4 0.312 P12111 R659H Polymorphism NA 0.434 0.03 36 0.573 P12111 R677H Disease NA 0.753 0.00 58 0.726 P12111 T538M Polymorphism NA 0.329 0.16 -17 0.477 P12111 A2941V Disease NA 0.371 0.32 11 0.117 P12111 D1674N Disease NA 0.540 0.63 7 0.382 P12111 E1386K Disease NA 0.248 0.69 -8 0.243 P12111 E2453K Polymorphism 0.393 0.333 0.44 56 0.355 P12111 G1679E Disease NA 0.913 0.01 47 0.875 P12111 G2047D Disease 0.572 0.834 0.00 70 0.996 P12111 G2056R Disease 0.650 0.897 0.00 69 0.995 P12111 G2080D Disease 0.572 0.891 0.00 69 0.996 P12111 K1014E Disease NA 0.401 0.33 43 0.391 P12111 K1088Q Polymorphism NA 0.680 0.52 -12 0.417 P12111 L1726R Disease NA 0.604 0.04 38 0.521 P12111 N1467D Disease NA 0.329 1.00 0 0.190 P12111 R1064Q Disease NA 0.239 0.18 26 0.353 P12111 R1395Q Disease NA 0.254 0.54 17 0.244 P12111 R1576Q Polymorphism NA 0.189 0.60 -9 0.202 P12111 R1632Q Polymorphism NA 0.211 0.60 12 0.258 P12111 T3069I Polymorphism NA 0.175 0.00 26 0.145 P12111 V1985M Disease NA 0.409 0.15 41 0.485 P12235 A90D Disease 0.864 0.760 0.19 58 0.910 P12235 L98P Disease 0.612 0.847 0.13 33 0.846 P12235 A114P Disease NA 0.854 0.29 31 0.566 P12235 D104G Disease 0.526 0.407 0.55 26 0.565 P12235 V289M Disease 0.262 0.240 0.23 21 0.353 P12236 S242F Polymorphism 0.920 0.768 0.03 28 0.865 P12259 C613R Disease 0.510 0.818 0.01 66 0.865 P12259 D107H Polymorphism 0.239 0.739 0.30 7 0.515 P12259 I387T Disease 0.296 0.971 0.00 55 0.685 P12259 K858R Polymorphism NA 0.085 0.00 -64 0.063 P12259 K925E Polymorphism NA 0.078 1.00 -38 0.026 P12259 M413T Polymorphism 0.089 0.518 0.06 24 0.102 P12259 N817T Polymorphism NA 0.288 0.01 14 0.254 P12259 P809S Polymorphism NA 0.145 0.00 10 0.176 P12259 R334T Disease 0.258 0.482 0.12 57 0.379 P12259 R534Q Polymorphism 0.152 0.647 0.02 48 0.354 P12259 R980L Polymorphism NA 0.105 0.00 20 0.160 P12259 D2222G Polymorphism NA 0.895 0.00 34 0.817 P12259 E1530A Polymorphism NA 0.283 0.16 22 0.352 P12259 H1146Q Polymorphism NA 0.084 0.20 18 0.088 P12259 K2185R Polymorphism 0.129 0.465 0.69 -14 0.109 P12259 L1397F Polymorphism NA 0.243 0.03 9 0.284 P12259 M1820I Polymorphism 0.373 0.925 0.01 56 0.756 P12259 M2148T Polymorphism 0.393 0.752 0.02 52 0.647 P12259 P1404S Polymorphism NA 0.457 0.01 24 0.337 P12259 R2102C Disease 0.962 0.958 0.00 56 0.917 P12259 R2102H Disease 0.910 0.937 0.00 35 0.889 P12259 Y1730C Disease 0.981 0.971 0.00 68 0.959 P12270 S960N Polymorphism 0.395 0.051 0.15 21 0.155 P12270 V1428G Polymorphism 0.452 0.212 0.00 34 0.406 P12271 R151Q Disease 0.427 0.826 0.37 38 0.657 P12271 R234W Disease 0.848 0.912 0.00 60 0.939 P12277 K177R Polymorphism 0.213 0.341 0.40 -22 0.250 P12277 S309L Polymorphism 0.305 0.399 0.09 -34 0.223 P12318 H167R Polymorphism 0.113 0.336 0.39 19 0.216 P12319 K84R Polymorphism 0.170 0.091 0.48 -10 0.128 P12319 S101N Polymorphism 0.989 0.821 0.01 57 0.954 P12429 S19N Polymorphism 0.072 0.533 0.74 -33 0.061 P12429 I219N Polymorphism 0.671 0.328 0.01 11 0.609 P12429 P251L Polymorphism 0.392 0.749 0.05 17 0.488 P12643 P77S Polymorphism 0.263 0.584 0.74 -42 0.262 P12643 A106T Polymorphism 0.723 0.857 0.01 -49 0.683 P12643 R190S Polymorphism 0.663 0.750 0.37 -11 0.797 P12644 E93G Disease 0.551 0.665 0.08 -9 0.505 P12644 S91C Disease 0.716 0.672 0.02 -18 0.734 P12644 A346V Disease 0.483 0.739 0.28 14 0.604 P12644 G168A Polymorphism NA 0.554 0.90 -34 0.349 P12644 R162Q Disease 0.524 0.802 0.24 -2 0.574 P12644 R226W Polymorphism 0.762 0.720 0.02 -1 0.744 P12644 R287H Disease 0.688 0.646 0.49 -31 0.726 P12644 V152A Polymorphism 0.376 0.258 1.00 -35 0.194 P12645 Q176L Polymorphism 0.143 0.129 0.32 0 0.173 P12645 R192Q Polymorphism 0.150 0.177 0.53 -36 0.144 P12694 P39H Polymorphism NA 0.117 0.34 -20 0.124 P12694 A253T Disease 0.810 0.914 0.00 46 0.883 P12694 F409C Disease 0.546 0.769 0.00 36 0.840 P12694 G290R Disease 0.864 0.921 0.01 63 0.928 P12694 I326T Disease 0.710 0.597 0.00 40 0.788 P12694 Q190K Disease 0.611 0.841 0.36 34 0.587 P12694 R159W Disease 0.996 0.939 0.00 77 0.947 P12694 T151M Polymorphism 0.526 0.424 0.11 11 0.605 P12694 Y413C Disease 0.960 0.941 0.00 57 0.951 P12694 Y438N Disease 0.816 0.938 0.00 41 0.875 P12724 R72C Polymorphism 0.580 0.556 0.00 42 0.755 P12724 G130R Polymorphism 0.439 0.223 0.42 14 0.114 P12724 T124R Polymorphism 0.621 0.166 1.00 -9 0.076 P12821 A154T Polymorphism NA 0.579 0.05 -4 0.504 P12821 A183T Polymorphism NA 0.454 0.50 -56 0.224 P12821 A261S Polymorphism NA 0.424 0.37 -23 0.184 P12821 D592G Polymorphism NA 0.349 0.41 11 0.222 P12821 G354R Polymorphism 0.358 0.738 0.04 28 0.628 P12821 M828T Polymorphism 0.129 0.252 0.50 -18 0.229 P12821 R260L Polymorphism NA 0.800 0.65 10 0.758 P12821 T916M Polymorphism 0.718 0.570 0.01 19 0.774 P12821 V524A Polymorphism 0.105 0.447 0.21 -25 0.261 P12821 Y244C Polymorphism NA 0.618 0.00 18 0.740 P12821 Q1296P Polymorphism 0.354 0.317 0.02 8 0.414 P12821 R1286S Polymorphism 0.094 0.127 0.13 -9 0.075 P12821 T1187M Polymorphism 0.780 0.659 0.01 43 0.812 P12829 N186Y Polymorphism 0.782 0.839 0.06 42 0.863 P12830 D72N Polymorphism NA 0.771 0.67 -41 0.438 P12830 C695R Polymorphism 0.447 0.775 0.01 30 0.713 P12830 E336D Polymorphism 0.719 0.344 0.00 12 0.492 P12830 E880K Polymorphism 0.552 0.566 0.03 35 0.596 P12830 I393N Polymorphism 0.646 0.366 0.00 41 0.655 P12830 L478P Polymorphism 0.671 0.473 0.28 28 0.665 P12830 L630V Polymorphism 0.724 0.678 0.01 48 0.708 P12830 T470I Polymorphism 0.750 0.369 0.00 0 0.613 P12830 V473I Polymorphism 0.197 0.302 0.06 -1 0.279 P12838 A8P Polymorphism NA 0.703 0.01 21 0.746 P12882 G640S Polymorphism 0.380 0.246 0.04 -22 0.272 P12882 Q1539H Polymorphism 0.345 0.124 0.26 -18 0.244 P12882 R1341C Polymorphism 0.789 0.552 0.00 29 0.794 P12882 R1716C Polymorphism NA 0.789 0.00 17 0.817 P12883 A26V Disease 0.425 0.622 0.20 -15 0.458 P12883 V39M Disease 0.678 0.493 0.00 32 0.758 P12883 V59I Disease 0.349 0.126 0.11 20 0.223 P12883 A196T Disease 0.746 0.796 0.00 -10 0.736 P12883 A223T Disease 0.158 0.635 0.30 -8 0.235 P12883 A355T Disease 0.613 0.929 0.00 31 0.740 P12883 A385V Disease 0.675 0.745 0.01 28 0.811 P12883 A428V Disease 0.435 0.862 0.00 -16 0.511 P12883 A430E Disease 0.722 0.781 0.00 46 0.866 P12883 A550V Disease 0.405 0.450 0.09 -12 0.475 P12883 A728V Disease 0.285 0.137 0.09 -13 0.239 P12883 A742E Disease 0.605 0.572 0.07 28 0.743 P12883 A797T Disease 0.332 0.307 0.08 15 0.358 P12883 A901G Disease 0.416 0.775 0.01 23 0.625 P12883 C905F Disease 0.412 0.414 0.22 22 0.374 P12883 D587V Disease 0.416 0.677 0.02 2 0.475 P12883 D778E Disease 0.308 0.220 0.00 -30 0.270 P12883 D778G Disease 0.702 0.434 0.00 32 0.662 P12883 D778V Disease 0.871 0.486 0.00 27 0.718 P12883 D906G Disease 0.353 0.463 0.32 14 0.371 P12883 D928N Disease 0.407 0.185 0.01 36 0.318 P12883 D953H Disease 0.522 0.383 0.27 12 0.563 P12883 E328G Disease NA 0.725 0.02 33 0.789 P12883 E466Q Polymorphism 0.965 0.885 0.00 54 0.943 P12883 E483K Disease 0.772 0.911 0.00 64 0.921 P12883 E499K Disease 0.582 0.837 0.00 33 0.713 P12883 E500A Disease 0.961 0.786 0.00 30 0.903 P12883 E743D Disease 0.382 0.235 0.17 -17 0.267 P12883 E774V Disease 0.983 0.729 0.00 61 0.940 P12883 E846Q Disease 0.431 0.287 0.10 8 0.358 P12883 E894G Disease 0.556 0.711 0.01 32 0.652 P12883 E921K Disease 0.590 0.362 0.01 53 0.649 P12883 E924K Disease 0.302 0.149 0.32 31 0.246 P12883 E924Q Disease 0.295 0.177 0.17 36 0.249 P12883 E927K Disease 0.354 0.251 0.03 26 0.379 P12883 E930K Disease 0.436 0.288 0.00 44 0.451 P12883 E931K Disease 0.339 0.187 0.01 13 0.305 P12883 E935K Disease 0.369 0.132 0.06 25 0.215 P12883 E949K Disease 0.319 0.230 0.04 24 0.368 P12883 F244L Disease 0.678 0.876 0.00 55 0.903 P12883 F312C Disease 0.631 0.766 0.00 56 0.818 P12883 F513C Disease 0.953 0.912 0.00 60 0.932 P12883 F764L Disease 0.924 0.907 0.00 50 0.884 P12883 G256E Disease 0.981 0.917 0.00 60 0.948 P12883 G407V Disease 0.933 0.670 0.00 36 0.863 P12883 G425R Disease 0.740 0.776 0.04 34 0.851 P12883 G571R Disease 0.370 0.777 0.03 -1 0.569 P12883 G584R Disease 0.990 0.937 0.00 66 0.950 P12883 G584S Disease 0.979 0.921 0.00 49 0.943 P12883 G716R Disease 0.347 0.367 0.07 -20 0.343 P12883 G733E Disease 0.235 0.730 0.01 14 0.506 P12883 G741R Disease 0.466 0.597 0.00 13 0.550 P12883 G741W Disease 0.798 0.533 0.00 17 0.754 P12883 G768R Disease 0.937 0.904 0.00 68 0.917 P12883 G823E Disease 0.178 0.516 0.77 -11 0.154 P12883 H576R Disease 0.650 0.772 0.01 25 0.787 P12883 I201T Disease 0.201 0.483 1.00 -47 0.185 P12883 I263M Disease 0.427 0.606 0.00 6 0.438 P12883 I263T Disease 0.748 0.751 0.00 48 0.831 P12883 I443T Disease 0.611 0.742 0.01 35 0.666 P12883 I511F Disease 0.710 0.843 0.00 57 0.905 P12883 I511T Disease 0.679 0.858 0.00 50 0.892 P12883 I736M Disease 0.295 0.159 0.86 -56 0.123 P12883 I736T Disease 0.202 0.290 0.17 -10 0.245 P12883 K146N Disease 0.622 0.225 0.00 -11 0.569 P12883 K207Q Disease NA 0.233 0.25 -23 0.253 P12883 K351E Disease 0.579 0.768 0.01 18 0.556 P12883 K383N Disease 0.451 0.569 0.08 -22 0.439 P12883 K450E Disease 0.403 0.451 0.01 9 0.410 P12883 K450T Disease 0.551 0.234 0.01 -16 0.572 P12883 K615N Disease 0.345 0.638 0.11 -27 0.450 P12883 K615Q Disease 0.278 0.416 0.05 -37 0.274 P12883 L227V Disease 0.570 0.854 0.00 38 0.858 P12883 L390V Disease 0.127 0.284 0.02 -69 0.225 P12883 L517M Disease NA 0.730 0.00 33 0.791 P12883 L601V Disease 0.899 0.465 0.00 -19 0.611 P12883 L796F Disease 0.568 0.664 0.01 26 0.595 P12883 L908V Disease 0.590 0.601 0.00 11 0.548 P12883 M349T Disease 0.140 0.715 0.02 11 0.296 P12883 M435T Disease 0.668 0.728 0.00 17 0.812 P12883 M515R Disease 0.619 0.852 0.00 30 0.623 P12883 M515V Disease 0.341 0.476 0.01 -3 0.350 P12883 M659I Disease 0.685 0.761 0.00 21 0.677 P12883 M822L Disease 0.123 0.213 1.00 -37 0.155 P12883 M822T Disease 0.315 0.399 0.02 19 0.402 P12883 M852T Disease 0.443 0.313 0.09 25 0.379 P12883 M877K Disease 0.290 0.197 0.27 34 0.294 P12883 N187K Disease 0.836 0.544 0.00 40 0.803 P12883 N232S Disease 0.951 0.920 0.00 42 0.928 P12883 N479S Disease 0.999 0.897 0.00 57 0.905 P12883 N602S Disease 0.598 0.315 0.00 -15 0.560 P12883 N696S Disease 0.952 0.318 0.00 16 0.613 P12883 P211L Disease NA 0.242 0.29 -28 0.344 P12883 P731L Disease 0.196 0.869 0.05 25 0.500 P12883 Q222K Disease 0.349 0.791 0.01 5 0.510 P12883 Q595R Disease 0.183 0.664 0.03 -14 0.328 P12883 Q734E Disease NA 0.226 0.16 -28 0.244 P12883 Q734P Disease NA 0.346 0.02 8 0.383 P12883 Q882E Disease 0.145 0.281 1.00 7 0.258 P12883 R143G Disease 0.544 0.284 0.01 32 0.618 P12883 R143Q Disease 0.263 0.206 0.04 0 0.254 P12883 R143W Disease 0.858 0.500 0.00 34 0.764 P12883 R190T Disease 0.647 0.436 0.01 28 0.651 P12883 R204H Disease NA 0.302 0.13 -15 0.258 P12883 R249Q Disease 0.622 0.559 0.00 1 0.498 P12883 R403L Disease 0.766 0.836 0.00 36 0.845 P12883 R403Q Disease 0.602 0.500 0.00 6 0.498 P12883 R403W Disease 0.946 0.818 0.00 41 0.868 P12883 R453C Disease 0.903 0.690 0.07 20 0.731 P12883 R453H Disease 0.740 0.467 0.09 -1 0.679 P12883 R663C Disease 0.860 0.690 0.00 19 0.762 P12883 R663H Disease 0.249 0.487 0.16 -27 0.299 P12883 R663S Disease 0.439 0.207 0.11 -9 0.226 P12883 R671C Disease 0.960 0.946 0.02 60 0.952 P12883 R694C Disease 0.825 0.958 0.00 49 0.913 P12883 R694H Disease 0.695 0.853 0.01 46 0.835 P12883 R712L Disease 0.883 0.925 0.00 59 0.892 P12883 R719Q Disease 0.269 0.284 0.06 15 0.342 P12883 R719W Disease 0.783 0.603 0.00 18 0.742 P12883 R723C Disease 0.382 0.685 0.10 5 0.485 P12883 R723G Disease 0.329 0.261 0.20 17 0.348 P12883 R787C Disease 0.494 0.588 0.18 25 0.744 P12883 R787H Disease 0.435 0.281 0.54 -19 0.350 P12883 R858C Disease 0.612 0.477 0.00 6 0.661 P12883 R858H Disease 0.266 0.236 0.01 -13 0.286 P12883 R869C Disease 0.623 0.363 0.02 42 0.653 P12883 R869G Disease 0.323 0.303 0.16 29 0.396 P12883 R869H Disease 0.359 0.170 0.05 14 0.282 P12883 R870C Disease 0.855 0.579 0.01 15 0.759 P12883 R870H Disease 0.646 0.356 0.08 -12 0.601 P12883 S148I Disease 0.373 0.434 0.08 -3 0.375 P12883 S532P Disease 0.795 0.914 0.01 26 0.769 P12883 S642L Disease 0.513 0.201 0.02 5 0.382 P12883 S782N Disease 0.380 0.139 0.17 -17 0.190 P12883 T124I Disease 0.287 0.405 0.07 27 0.495 P12883 T188N Disease 0.784 0.785 0.00 22 0.836 P12883 T412N Disease 0.243 0.306 0.21 -19 0.261 P12883 T441M Disease 0.458 0.190 0.15 -41 0.277 P12883 V186L Disease 0.465 0.549 0.22 12 0.680 P12883 V320M Disease NA 0.680 0.00 39 0.801 P12883 V404L Disease 0.442 0.483 0.01 -13 0.357 P12883 V404M Disease 0.720 0.398 0.00 -13 0.568 P12883 V406M Disease 0.786 0.418 0.00 22 0.669 P12883 V411I Disease 0.274 0.146 0.00 -12 0.300 P12883 V440M Disease 0.754 0.844 0.00 31 0.844 P12883 V606M Disease 0.671 0.321 0.01 -4 0.576 P12883 V698A Disease 0.915 0.518 0.00 38 0.816 P12883 V763G Disease 0.905 0.825 0.00 43 0.882 P12883 V763M Disease 0.749 0.752 0.00 27 0.812 P12883 V824I Disease 0.298 0.157 0.04 19 0.266 P12883 Y115H Disease 0.450 0.874 0.00 70 0.903 P12883 Y162C Disease 0.946 0.958 0.00 48 0.926 P12883 Y501C Disease 0.988 0.858 0.00 51 0.944 P12883 A1124S Polymorphism 0.361 0.422 0.51 -58 0.276 P12883 A1379T Disease NA 0.388 0.03 -3 0.285 P12883 A1454T Disease 0.331 0.552 0.03 -30 0.480 P12883 A1663P Disease NA 0.744 0.17 14 0.728 P12883 A1777T Disease NA 0.363 0.21 -25 0.385 P12883 E1218Q Disease 0.817 0.579 0.00 -17 0.744 P12883 E1356K Disease 0.568 0.256 0.05 -1 0.560 P12883 E1426K Disease 0.521 0.534 0.02 16 0.488 P12883 E1555K Disease 0.668 0.642 0.00 10 0.780 P12883 E1753K Disease NA 0.516 0.01 16 0.695 P12883 E1768K Disease NA 0.648 0.00 1 0.495 P12883 E1883K Disease NA 0.736 0.00 2 0.647 P12883 G1057D Disease 0.598 0.652 0.01 -9 0.529 P12883 G1057S Disease 0.457 0.338 0.01 -36 0.302 P12883 H1901L Disease NA 0.494 0.24 -6 0.435 P12883 K1459N Disease 0.630 0.459 0.09 -9 0.559 P12883 K1919N Polymorphism NA 0.766 0.02 15 0.589 P12883 L1135R Disease 0.116 0.431 0.18 -21 0.244 P12883 L1414M Disease 0.650 0.685 0.01 -15 0.760 P12883 L1706P Disease NA 0.900 0.14 27 0.817 P12883 N1327K Disease 0.185 0.330 1.00 -22 0.278 P12883 R1193S Disease 0.643 0.794 0.00 13 0.786 P12883 R1382W Disease 0.909 0.617 0.03 25 0.784 P12883 R1420W Disease 0.930 0.744 0.00 29 0.875 P12883 R1475C Polymorphism 0.913 0.728 0.00 37 0.866 P12883 R1500P Disease 0.817 0.884 0.00 42 0.874 P12883 R1634C Disease NA 0.826 0.00 28 0.697 P12883 R1712W Disease NA 0.693 0.00 22 0.771 P12883 R1845W Disease NA 0.916 0.00 25 0.823 P12883 S1491C Polymorphism 0.637 0.543 0.14 -27 0.639 P12883 S1776G Disease NA 0.420 0.03 -8 0.392 P12883 T1019N Disease 0.181 0.159 0.41 -42 0.138 P12883 T1377M Disease 0.542 0.316 0.02 -34 0.586 P12883 T1513S Disease 0.352 0.279 0.03 -34 0.276 P12883 T1854M Disease NA 0.275 0.02 -24 0.344 P12883 T1929M Disease NA 0.234 0.05 5 0.348 P12931 A237T Polymorphism 0.324 0.371 0.15 26 0.440 P12931 L176F Polymorphism 0.387 0.628 0.00 38 0.757 P12955 D276N Disease 0.920 0.900 0.00 73 0.931 P12955 G278D Disease 0.916 0.870 0.00 73 0.928 P12955 G448R Disease 0.934 0.808 0.00 69 0.928 P12955 R184Q Disease NA 0.899 0.00 68 0.918 P12955 R388H Polymorphism NA 0.380 0.00 -11 0.364 P13051 Q4R Polymorphism NA 0.440 0.00 35 0.588 P13051 F251S Disease 0.446 0.904 0.00 44 0.835 P13224 A133P Disease 0.271 0.425 0.31 -22 0.364 P13224 Y113C Disease 0.597 0.361 0.07 30 0.577 P13236 M12V Polymorphism 0.155 0.183 0.26 -52 0.114 P13236 P20L Polymorphism 0.076 0.180 0.43 -8 0.080 P13236 S80T Polymorphism 0.165 0.169 0.22 -46 0.116 P13385 V22A Polymorphism NA 0.051 0.65 -51 0.004 P13473 W321R Disease 0.838 0.713 0.09 58 0.919 P13498 G24R Disease 0.785 0.868 0.00 75 0.917 P13498 H94R Disease 0.593 0.813 0.00 36 0.817 P13498 R90Q Disease 0.557 0.827 0.00 61 0.886 P13498 P156Q Disease 0.762 0.262 0.00 28 0.591 P13498 S118R Disease 0.631 0.712 0.00 52 0.875 P13501 S24F Polymorphism 0.738 0.589 0.05 28 0.725 P13521 A196V Polymorphism 0.630 0.343 0.00 26 0.609 P13521 R421G Polymorphism 0.081 0.294 0.35 15 0.207 P13533 I820N Disease 0.841 0.608 0.00 12 0.759 P13533 L783M Polymorphism 0.623 0.459 0.01 8 0.526 P13533 R795Q Disease 0.512 0.789 0.05 59 0.833 P13533 T1737S Polymorphism NA 0.156 0.77 -70 0.118 P13533 V1101A Polymorphism 0.206 0.138 1.00 -56 0.095 P13535 A636V Polymorphism 0.274 0.279 0.43 -17 0.261 P13535 E924G Polymorphism 0.631 0.886 0.00 46 0.729 P13535 I326T Polymorphism NA 0.308 0.06 18 0.370 P13535 R674Q Disease 0.832 0.876 0.00 62 0.925 P13535 W1692R Polymorphism NA 0.287 1.00 -21 0.025 P13569 D44G Disease 0.539 0.753 0.01 52 0.868 P13569 D44V Polymorphism 0.713 0.732 0.00 52 0.891 P13569 E92K Disease 0.445 0.642 0.86 28 0.556 P13569 F87L Disease 0.213 0.620 1.00 -31 0.327 P13569 G85E Disease 0.670 0.931 0.28 44 0.879 P13569 G91R Disease 0.744 0.781 0.29 27 0.602 P13569 P67L Disease 0.700 0.616 0.38 7 0.773 P13569 Q98R Disease 0.404 0.759 0.35 53 0.785 P13569 R31C Polymorphism NA 0.766 0.05 39 0.831 P13569 R31L Disease NA 0.508 0.25 32 0.765 P13569 R74W Disease 0.740 0.649 0.18 41 0.421 P13569 R75Q Polymorphism 0.505 0.715 0.42 57 0.688 P13569 S13F Disease NA 0.784 0.00 45 0.789 P13569 S42F Disease 0.532 0.570 0.04 27 0.580 P13569 S50Y Disease 0.730 0.130 0.15 40 0.275 P13569 W57G Disease 0.704 0.735 0.13 46 0.864 P13569 A120T Disease 0.315 0.513 0.42 36 0.469 P13569 A141D Disease 0.608 0.819 0.20 65 0.894 P13569 A455E Disease 0.589 0.837 0.00 42 0.859 P13569 A559T Disease 0.992 0.798 0.01 49 0.926 P13569 A613T Disease 0.416 0.478 0.03 55 0.563 P13569 A800G Disease NA 0.428 0.33 -37 0.220 P13569 C225R Disease 0.744 0.847 0.07 61 0.751 P13569 C866Y Disease 0.475 0.846 0.26 43 0.784 P13569 D110H Disease 0.707 0.371 0.56 44 0.603 P13569 D513G Disease 0.560 0.693 0.08 26 0.788 P13569 D572N Disease 0.996 0.854 0.00 46 0.919 P13569 D579G Disease 0.995 0.921 0.00 61 0.931 P13569 D614G Disease 0.538 0.846 0.01 45 0.732 P13569 D648V Disease 0.589 0.401 0.34 16 0.568 P13569 D651N Disease 0.141 0.415 0.11 30 0.259 P13569 E193K Disease 0.445 0.709 0.18 42 0.662 P13569 E504Q Disease 0.331 0.524 0.04 28 0.461 P13569 E822K Disease NA 0.280 0.06 43 0.355 P13569 F311L Disease 0.330 0.329 0.72 42 0.388 P13569 F693L Polymorphism NA 0.230 0.21 30 0.295 P13569 G149R Disease 0.744 0.931 0.00 64 0.944 P13569 G178R Disease 0.475 0.828 0.00 76 0.906 P13569 G314E Disease 0.437 0.641 0.29 49 0.353 P13569 G314R Disease 0.529 0.580 0.36 52 0.634 P13569 G458V Disease 0.727 0.857 0.00 51 0.863 P13569 G480C Disease 0.829 0.846 0.00 32 0.881 P13569 G544V Disease 0.720 0.559 0.13 36 0.780 P13569 G551D Disease 0.998 0.908 0.00 66 0.941 P13569 G551S Disease 0.997 0.868 0.00 54 0.938 P13569 G576A Polymorphism 0.152 0.520 0.13 -10 0.115 P13569 G628R Disease 0.743 0.819 0.00 74 0.881 P13569 H139R Disease 0.206 0.791 0.32 60 0.499 P13569 H199Q Disease 0.605 0.800 0.54 40 0.584 P13569 H199Y Disease 0.542 0.901 1.00 35 0.691 P13569 H620P Disease 0.719 0.699 0.18 34 0.817 P13569 H620Q Disease 0.603 0.427 0.64 32 0.451 P13569 H949Y Disease 0.537 0.865 0.00 38 0.530 P13569 I105S Disease 0.599 0.500 0.05 18 0.736 P13569 I148T Disease 0.448 0.288 0.36 51 0.320 P13569 I336K Disease 0.674 0.592 0.92 52 0.820 P13569 I506V Polymorphism 0.191 0.851 0.09 54 0.382 P13569 I507V Polymorphism 0.087 0.500 1.00 14 0.058 P13569 I601F Disease 0.516 0.870 0.03 47 0.725 P13569 I618T Disease 0.447 0.558 0.00 30 0.606 P13569 I807M Disease NA 0.544 0.04 7 0.650 P13569 K532E Polymorphism 0.280 0.625 0.89 -17 0.163 P13569 L138P Polymorphism 0.785 0.915 0.18 47 0.880 P13569 L206W Disease 0.846 0.770 0.04 44 0.861 P13569 L346P Disease 0.787 0.871 0.06 51 0.865 P13569 L467F Polymorphism 0.482 0.854 0.01 43 0.581 P13569 L558S Disease 0.665 0.818 0.00 12 0.832 P13569 L571S Disease 0.658 0.770 0.00 39 0.849 P13569 L610S Disease 0.662 0.823 0.00 52 0.860 P13569 L619S Disease 0.662 0.751 0.00 22 0.822 P13569 L633P Disease 0.784 0.830 0.00 61 0.776 P13569 L997F Disease NA 0.210 0.69 -58 0.160 P13569 M244K Disease 0.524 0.659 0.12 43 0.560 P13569 M952I Disease 0.292 0.656 0.11 5 0.199 P13569 N287Y Disease 0.570 0.186 0.02 30 0.412 P13569 P111L Disease 0.385 0.500 0.28 24 0.458 P13569 P205S Disease 0.580 0.801 0.47 24 0.525 P13569 P574H Disease 0.827 0.738 0.00 54 0.887 P13569 Q353H Polymorphism 0.647 0.274 0.31 58 0.616 P13569 Q359K Disease 0.353 0.309 0.37 58 0.312 P13569 R117C Disease 0.844 0.825 0.07 58 0.917 P13569 R117H Disease 0.672 0.337 0.18 52 0.541 P13569 R117L Disease 0.592 0.495 0.44 24 0.383 P13569 R117P Disease 0.710 0.747 0.33 66 0.718 P13569 R258G Disease 0.611 0.883 0.07 48 0.881 P13569 R297Q Disease 0.507 0.525 0.30 52 0.529 P13569 R334W Disease 0.884 0.650 0.08 43 0.779 P13569 R347H Disease 0.674 0.693 0.56 24 0.759 P13569 R347L Disease 0.594 0.762 0.75 25 0.555 P13569 R347P Disease 0.712 0.928 0.26 55 0.819 P13569 R352Q Disease 0.507 0.228 0.71 61 0.689 P13569 R553Q Disease 0.508 0.652 0.00 46 0.644 P13569 R560K Disease 0.994 0.888 0.00 63 0.937 P13569 R560S Disease 0.998 0.905 0.00 60 0.937 P13569 R560T Disease 0.998 0.882 0.00 67 0.938 P13569 R766M Disease NA 0.426 0.00 46 0.617 P13569 R792G Disease NA 0.547 0.20 26 0.490 P13569 S182G Polymorphism 0.425 0.592 0.04 59 0.783 P13569 S307N Disease 0.528 0.417 0.42 51 0.577 P13569 S492F Disease 0.613 0.822 0.03 31 0.836 P13569 S549I Disease 0.998 0.878 0.00 68 0.941 P13569 S549N Disease 0.995 0.921 0.00 63 0.940 P13569 S549R Disease 0.997 0.910 0.00 74 0.942 P13569 S605F Polymorphism 0.712 0.755 0.00 44 0.848 P13569 T338I Disease 0.522 0.474 0.18 31 0.552 P13569 T665S Disease 0.212 0.388 0.27 40 0.320 P13569 V456F Disease 0.491 0.768 0.46 42 0.806 P13569 V520F Disease 0.593 0.694 0.01 32 0.801 P13569 V562I Polymorphism 0.213 0.373 0.60 11 0.304 P13569 V562L Disease 0.284 0.591 1.00 -5 0.183 P13569 V754M Disease NA 0.106 0.42 -33 0.072 P13569 Y109C Disease 0.799 0.871 0.04 55 0.873 P13569 Y301C Disease 0.799 0.853 0.09 45 0.763 P13569 Y563N Disease 0.690 0.914 0.00 44 0.874 P13569 Y569C Disease 0.832 0.889 0.00 56 0.897 P13569 Y569D Disease 0.724 0.892 0.00 61 0.865 P13569 Y569H Disease 0.597 0.807 0.00 62 0.846 P13569 Y913C Disease 0.832 0.806 0.06 12 0.830 P13569 Y917C Disease 0.832 0.819 0.02 13 0.836 P13569 A1006E Disease 0.201 0.535 0.03 12 0.568 P13569 A1067T Disease 0.391 0.702 0.04 28 0.523 P13569 A1364V Disease 0.438 0.478 0.01 29 0.585 P13569 D1152H Disease 0.404 0.494 0.57 40 0.712 P13569 D1270N Disease 0.442 0.809 0.03 70 0.698 P13569 F1052V Disease 0.456 0.563 0.48 11 0.455 P13569 F1286S Disease 0.612 0.803 0.00 45 0.858 P13569 G1061R Disease 0.998 0.830 0.00 73 0.944 P13569 G1244E Disease 0.999 0.918 0.00 77 0.977 P13569 G1249E Disease 0.999 0.935 0.00 72 0.981 P13569 G1349D Disease 0.998 0.935 0.00 73 0.984 P13569 H1085R Disease 0.498 0.349 0.35 46 0.477 P13569 I1005R Disease 0.671 0.533 0.04 45 0.812 P13569 I1234V Disease 0.076 0.712 0.48 -24 0.172 P13569 L1065P Disease 0.741 0.906 0.00 31 0.876 P13569 L1065R Disease 0.669 0.824 0.00 51 0.851 P13569 L1077P Disease 0.765 0.766 0.25 46 0.770 P13569 M1028I Disease 0.116 0.112 0.54 -38 0.086 P13569 M1101K Disease 0.486 0.516 0.29 49 0.763 P13569 M1101R Disease 0.507 0.513 0.38 41 0.777 P13569 M1137V Disease 0.280 0.313 0.46 -16 0.223 P13569 N1303H Disease 0.998 0.907 0.00 76 0.975 P13569 N1303K Disease 0.998 0.906 0.00 73 0.976 P13569 P1013L Disease 0.669 0.769 0.14 37 0.697 P13569 P1072L Disease 0.320 0.118 0.18 -25 0.213 P13569 Q1071P Disease 0.628 0.765 0.01 48 0.839 P13569 Q1291H Disease 0.999 0.904 0.00 68 0.975 P13569 Q1291R Disease 0.999 0.915 0.00 67 0.977 P13569 R1066C Disease 0.827 0.864 0.04 56 0.868 P13569 R1066H Disease 0.645 0.837 0.14 36 0.557 P13569 R1066L Disease 0.560 0.918 0.16 46 0.816 P13569 R1070P Disease 0.685 0.716 0.26 12 0.792 P13569 R1070Q Disease 0.475 0.101 0.61 -22 0.139 P13569 R1070W Disease 0.871 0.587 0.02 -24 0.411 P13569 R1283M Disease 0.999 0.878 0.00 62 0.945 P13569 S1235R Disease 0.295 0.620 0.39 -12 0.139 P13569 S1251N Disease 0.496 0.879 0.00 66 0.887 P13569 S1255P Disease 0.461 0.744 0.17 20 0.741 P13569 V1397E Disease 0.661 0.846 0.01 48 0.881 P13569 W1098R Disease 0.709 0.758 0.40 68 0.829 P13569 W1282R Disease 0.709 0.779 0.00 12 0.736 P13584 F354C Polymorphism 0.391 0.272 0.08 6 0.300 P13584 M331I Polymorphism 0.184 0.402 0.01 -19 0.176 P13584 R264W Polymorphism 0.989 0.907 0.00 49 0.937 P13584 R274Q Polymorphism 0.404 0.132 0.59 -19 0.140 P13584 R340C Polymorphism 0.575 0.724 0.00 35 0.641 P13584 S322G Polymorphism 0.301 0.336 0.02 32 0.424 P13584 V345I Polymorphism 0.144 0.081 0.67 -57 0.104 P13598 A37T Polymorphism 0.226 0.143 0.15 23 0.215 P13598 R199H Polymorphism 0.114 0.066 0.51 -25 0.079 P13611 F2301Y Polymorphism NA 0.087 1.00 -20 0.041 P13611 K1516R Polymorphism NA 0.062 0.62 7 0.060 P13611 N3011K Polymorphism NA 0.264 0.11 55 0.378 P13611 R1826H Polymorphism NA 0.080 0.15 27 0.061 P13611 V2315L Polymorphism NA 0.060 0.97 13 0.063 P13612 S634T Polymorphism 0.100 0.518 0.49 -12 0.070 P13612 V824A Polymorphism 0.318 0.402 0.04 40 0.428 P13637 D801Y Disease 0.885 0.831 0.00 49 0.913 P13637 E277K Disease 0.296 0.630 0.85 19 0.408 P13637 F780L Disease 0.511 0.477 0.06 -29 0.528 P13637 I274T Disease 0.415 0.733 0.00 29 0.774 P13637 I758S Disease 0.818 0.848 0.00 38 0.861 P13637 T613M Disease 0.441 0.946 0.00 50 0.894 P13645 G126S Polymorphism 0.279 0.221 0.88 -45 0.262 P13645 I101S Polymorphism NA 0.157 0.45 -33 0.137 P13645 I446T Disease 0.970 0.907 0.00 40 0.906 P13645 K439E Disease 0.935 0.875 0.00 53 0.929 P13645 L161S Disease 0.984 0.657 0.00 31 0.843 P13645 L442Q Disease 0.989 0.891 0.00 53 0.938 P13645 M150R Disease 0.986 0.945 0.00 53 0.940 P13645 N154H Disease 0.992 0.862 0.00 46 0.908 P13645 R156C Disease 0.990 0.940 0.00 39 0.923 P13645 R156H Disease 0.927 0.897 0.00 29 0.897 P13645 R156P Disease 0.976 0.965 0.00 58 0.942 P13645 R156S Disease 0.959 0.811 0.00 35 0.875 P13645 R422E Disease 0.933 0.608 0.00 35 0.814 P13645 Y160D Disease 0.991 0.831 0.00 59 0.938 P13645 Y160N Disease 0.988 0.883 0.00 47 0.912 P13645 Y160S Disease 0.987 0.677 0.00 43 0.875 P13646 A146G Polymorphism 0.176 0.055 1.00 -53 0.054 P13646 L111P Disease 0.990 0.936 0.00 57 0.942 P13646 L115P Disease 0.991 0.961 0.00 53 0.942 P13646 L119P Disease 0.986 0.939 0.00 47 0.916 P13646 M108T Disease 0.981 0.901 0.00 44 0.916 P13646 N112S Disease 0.977 0.881 0.00 30 0.902 P13647 P25L Disease NA 0.546 0.01 -14 0.479 P13647 S79R Polymorphism NA 0.232 0.04 28 0.336 P13647 A438D Disease 0.970 0.829 0.00 27 0.844 P13647 D158V Disease 0.985 0.856 0.00 45 0.915 P13647 D328E Disease 0.847 0.716 0.00 -12 0.781 P13647 D328G Disease 0.925 0.769 0.00 33 0.854 P13647 D328H Disease 0.965 0.874 0.00 40 0.878 P13647 D328V Disease 0.923 0.845 0.00 32 0.859 P13647 E167K Disease 0.568 0.331 0.02 3 0.620 P13647 E168K Disease 0.994 0.669 0.00 53 0.936 P13647 E170K Disease 0.784 0.558 0.00 9 0.783 P13647 E190K Disease 0.994 0.934 0.00 38 0.917 P13647 E418K Disease 0.995 0.940 0.00 41 0.840 P13647 E475G Disease 0.992 0.794 0.00 32 0.897 P13647 E475K Disease 0.995 0.876 0.00 44 0.905 P13647 E477K Disease 0.895 0.832 0.00 43 0.849 P13647 F179S Disease 0.995 0.828 0.00 38 0.907 P13647 G138E Polymorphism 0.930 0.765 0.01 33 0.867 P13647 G517D Disease 0.676 0.244 0.43 26 0.439 P13647 I161S Disease 0.886 0.766 0.00 35 0.872 P13647 I467T Disease 0.992 0.927 0.00 38 0.916 P13647 K173N Disease 0.894 0.736 0.00 17 0.857 P13647 K199T Disease 0.917 0.760 0.00 39 0.870 P13647 K404E Disease 0.901 0.772 0.00 36 0.852 P13647 L175F Disease 0.840 0.918 0.00 39 0.884 P13647 L311P Disease 0.958 0.889 0.00 47 0.913 P13647 L325P Disease 0.974 0.916 0.00 32 0.905 P13647 L463P Disease 0.996 0.929 0.00 62 0.943 P13647 M327K Disease 0.969 0.884 0.00 36 0.900 P13647 M327T Disease 0.945 0.812 0.00 11 0.852 P13647 N176S Disease 0.905 0.895 0.00 29 0.900 P13647 N177S Disease 0.576 0.595 0.11 -12 0.513 P13647 N193K Disease 0.995 0.829 0.00 43 0.920 P13647 N329K Disease 0.880 0.513 0.00 20 0.771 P13647 P152L Disease 0.984 0.868 0.00 26 0.907 P13647 Q191P Disease 0.979 0.926 0.00 43 0.916 P13647 R169P Disease 0.912 0.913 0.00 54 0.931 P13647 R331C Disease 0.715 0.812 0.00 31 0.752 P13647 R331H Disease 0.847 0.747 0.00 -4 0.810 P13647 R352S Disease 0.645 0.242 0.04 6 0.604 P13647 S181P Disease 0.927 0.934 0.00 39 0.887 P13647 S232N Polymorphism 0.346 0.357 0.57 -56 0.200 P13647 S387T Polymorphism 0.555 0.203 0.27 -42 0.456 P13647 T469P Disease 0.952 0.908 0.00 45 0.912 P13647 V143D Disease 0.981 0.920 0.00 62 0.949 P13647 V186L Disease 0.995 0.905 0.00 23 0.921 P13647 V186M Disease 0.998 0.938 0.00 31 0.857 P13647 V323A Disease 0.896 0.767 0.00 16 0.815 P13647 V324D Disease 0.976 0.840 0.00 13 0.879 P13671 S470F Polymorphism NA 0.337 0.01 30 0.542 P13686 V221I Polymorphism 0.102 0.103 0.68 -30 0.106 P13688 A83V Polymorphism 0.093 0.117 1.00 -41 0.092 P13688 Q376R Polymorphism 0.097 0.260 0.42 50 0.164 P13693 V146F Polymorphism 0.723 0.876 0.00 43 0.873 P13716 A274T Disease 0.497 0.784 0.04 23 0.785 P13716 G133R Disease 0.969 0.910 0.00 68 0.903 P13716 R240W Disease 0.881 0.779 0.04 -14 0.816 P13716 V153M Disease 0.406 0.432 0.14 -45 0.204 P13716 V275M Disease 0.712 0.668 0.05 21 0.781 P13725 T9M Polymorphism NA 0.254 NA 44 0.067 P13726 R163W Polymorphism 0.597 0.365 0.13 39 0.579 P13746 R89G Polymorphism 0.477 0.778 0.06 17 0.627 P13746 A176E Polymorphism 0.207 0.318 0.40 -6 0.242 P13746 D101N Polymorphism 0.347 0.243 1.00 -37 0.235 P13746 F133L Polymorphism 0.259 0.135 1.00 -27 0.106 P13746 G131W Polymorphism 0.626 0.834 0.07 44 0.717 P13746 I166T Polymorphism 0.408 0.801 0.46 16 0.691 P13746 K168E Polymorphism 0.582 0.760 0.15 37 0.745 P13746 N151K Polymorphism 0.576 0.954 0.03 53 0.783 P13746 R169H Polymorphism 0.507 0.873 0.17 -7 0.601 P13746 R205H Polymorphism 0.767 0.852 0.04 4 0.806 P13746 T345S Polymorphism 0.145 0.221 1.00 -1 0.230 P13747 N98K Polymorphism 0.410 0.876 0.01 32 0.762 P13747 G104R Polymorphism 0.242 0.744 0.45 -13 0.464 P13747 R128G Polymorphism 0.380 0.174 1.00 4 0.100 P13747 R178G Polymorphism 0.814 0.912 0.00 50 0.822 P13760 L96I Polymorphism 0.193 0.181 0.57 -40 0.126 P13760 Q99D Polymorphism 0.373 0.622 0.24 0 0.443 P13760 K100E Polymorphism 0.276 0.524 0.95 -1 0.305 P13760 T262R Polymorphism NA 0.781 0.61 36 0.687 P13761 V107Y Polymorphism 0.281 0.236 1.00 -3 0.280 P13765 R18Q Polymorphism 0.346 0.446 0.24 6 0.463 P13765 L234F Polymorphism 0.861 0.812 0.02 32 0.815 P13765 V244I Polymorphism 0.180 0.123 0.64 -50 0.113 P13798 T541M Polymorphism 0.801 0.577 0.22 13 0.749 P13804 G116R Disease 0.981 0.927 0.01 70 0.940 P13804 T266M Disease 0.949 0.869 0.00 64 0.928 P13804 V157G Disease 0.843 0.875 0.00 49 0.909 P13807 E359G Polymorphism 0.213 0.206 0.19 2 0.258 P13807 I108M Polymorphism 0.665 0.920 0.01 46 0.885 P13807 M416V Polymorphism 0.128 0.127 0.67 -20 0.128 P13866 D28G Disease NA 0.905 0.01 57 0.906 P13866 D28N Disease NA 0.898 0.02 59 0.800 P13866 N51S Polymorphism NA 0.595 0.55 12 0.410 P13866 A468V Disease NA 0.606 0.47 -52 0.356 P13866 G318R Disease 0.857 0.936 0.01 50 0.903 P13866 R135W Disease NA 0.938 0.00 62 0.928 P13928 G177A Polymorphism 0.073 0.549 0.74 -58 0.035 P13929 S71N Polymorphism 0.178 0.326 0.57 -52 0.145 P13942 G661R Disease NA 0.766 0.00 76 0.967 P13942 G808E Disease NA 0.524 0.00 69 0.927 P13942 P236S Polymorphism NA 0.500 0.11 -5 0.478 P13942 P621T Disease NA 0.455 0.24 16 0.368 P13942 E1628D Polymorphism 0.091 0.208 0.50 -40 0.185 P13942 G1441E Disease 0.998 0.702 0.00 57 0.969 P13942 P1722L Polymorphism NA 0.055 0.21 -36 0.097 P13942 R1034C Disease NA 0.534 0.02 54 0.757 P13942 R1600Q Polymorphism 0.139 0.222 0.05 -44 0.187 P13945 W64R Polymorphism 0.298 0.348 1.00 18 0.050 P13945 E249K Polymorphism 0.394 0.122 0.79 14 0.163 P13994 S22C Polymorphism 0.911 0.798 0.05 29 0.859 P14060 G90S Polymorphism 0.372 0.750 0.02 -41 0.553 P14060 R71I Polymorphism 0.796 0.344 0.11 -27 0.583 P14060 T54I Polymorphism 0.374 0.143 0.57 -57 0.212 P14060 T367N Polymorphism 0.276 0.141 0.02 -25 0.254 P14091 T329I Polymorphism 0.508 0.603 0.46 5 0.447 P14136 D78E Disease 0.895 0.667 0.03 -21 0.783 P14136 L76F Disease 0.902 0.855 0.00 45 0.901 P14136 N77Y Disease 0.978 0.887 0.00 46 0.911 P14136 P47L Disease 0.592 0.300 0.42 10 0.563 P14136 R79C Disease 0.987 0.939 0.00 44 0.917 P14136 R79H Disease 0.972 0.857 0.00 36 0.890 P14136 R88C Disease 0.969 0.952 0.01 30 0.899 P14136 R88S Disease 0.899 0.883 0.01 28 0.886 P14136 A244V Disease 0.366 0.494 0.24 -33 0.200 P14136 E223Q Disease 0.404 0.595 0.03 -9 0.474 P14136 E362D Disease 0.909 0.857 0.00 39 0.866 P14136 R239C Disease 0.987 0.880 0.00 36 0.865 P14136 R239H Disease 0.973 0.828 0.00 32 0.855 P14136 R258P Disease 0.623 0.798 0.04 43 0.794 P14136 R416W Disease 0.741 0.915 0.19 42 0.865 P14138 A17T Disease 0.246 0.239 0.00 -47 0.222 P14138 A224T Disease 0.065 0.125 NA -12 0.043 P14138 C159F Disease 0.972 0.962 0.00 45 0.960 P14138 Y127C Disease 0.975 0.978 0.01 52 0.971 P14151 E201Q Polymorphism NA 0.127 0.34 30 0.222 P14151 N369D Polymorphism NA 0.060 0.98 -3 0.067 P14151 P213S Polymorphism NA 0.165 0.15 30 0.233 P14209 M166V Polymorphism 0.064 0.098 0.45 -1 0.049 P14209 N173I Polymorphism 0.228 0.165 0.07 5 0.144 P14222 A91V Polymorphism 0.295 0.287 0.15 39 0.385 P14222 V50M Disease NA 0.372 0.02 49 0.648 P14222 C279Y Disease 0.552 0.839 0.00 64 0.908 P14222 G429E Disease 0.678 0.829 0.03 37 0.821 P14222 I224N Disease 0.790 0.915 0.11 55 0.917 P14222 N252S Disease 0.089 0.069 0.51 -18 0.061 P14222 P345L Disease 0.971 0.907 0.00 47 0.945 P14222 R123H Polymorphism 0.215 0.225 0.13 16 0.291 P14222 R225W Disease 0.669 0.447 0.03 49 0.632 P14222 V135M Polymorphism 0.480 0.363 0.06 48 0.595 P14222 V183G Disease NA 0.518 0.04 47 0.652 P14314 S74N Polymorphism 0.274 0.445 0.12 -20 0.317 P14314 A338G Polymorphism NA 0.175 0.56 -8 0.078 P14317 E361K Polymorphism 0.373 0.266 0.62 0 0.239 P14317 V436L Polymorphism 0.558 0.062 1.00 -21 0.022 P14324 I391V Polymorphism 0.410 0.526 0.26 -14 0.485 P14384 V133I Polymorphism 0.116 0.089 0.03 35 0.185 P14406 E40D Polymorphism 0.105 0.090 0.44 -29 0.034 P14410 V15F Polymorphism NA 0.415 0.00 43 0.539 P14410 L341P Disease 0.594 0.886 0.17 60 0.893 P14410 L620P Disease 0.874 0.902 0.00 62 0.800 P14410 Q117R Disease NA 0.112 0.39 25 0.231 P14410 S594P Disease 0.546 0.933 0.01 41 0.808 P14410 T694P Disease 0.565 0.619 0.17 12 0.700 P14410 V577G Disease 0.573 0.287 0.00 29 0.602 P14410 C1229Y Disease NA 0.912 0.00 65 0.875 P14410 F1745C Disease NA 0.711 0.00 54 0.862 P14410 G1073D Disease NA 0.797 0.74 21 0.766 P14410 Q1098P Disease NA 0.913 0.09 38 0.866 P14410 R1367G Disease NA 0.319 0.42 34 0.424 P14415 T199A Polymorphism 0.255 0.148 0.72 -5 0.248 P14416 P310S Polymorphism NA 0.182 0.77 -7 0.167 P14416 V154I Disease 0.144 0.058 0.56 -27 0.075 P14543 S60R Polymorphism NA 0.221 0.02 30 0.283 P14543 K970E Polymorphism NA 0.129 0.33 31 0.282 P14543 R335H Polymorphism NA 0.103 0.01 31 0.135 P14543 Q1246R Polymorphism 0.066 0.097 0.06 -6 0.043 P14543 T1226I Polymorphism 0.179 0.082 0.12 33 0.231 P14550 E55D Polymorphism 0.631 0.785 0.03 33 0.591 P14598 R42Q Disease 0.507 0.943 0.01 63 0.925 P14598 R90H Polymorphism 0.743 0.905 0.00 48 0.888 P14598 A308V Polymorphism 0.467 0.361 0.04 38 0.332 P14616 C246R Polymorphism 0.811 0.983 0.00 64 0.955 P14616 P928L Polymorphism 0.560 0.132 0.55 -26 0.182 P14616 R244H Polymorphism 0.553 0.141 0.12 8 0.381 P14616 R554C Polymorphism NA 0.236 0.03 35 0.399 P14618 G204V Polymorphism 0.734 0.827 0.07 37 0.787 P14651 P82T Polymorphism NA 0.058 0.66 20 0.084 P14653 T71N Polymorphism NA 0.099 0.57 -1 0.055 P14672 S55R Polymorphism 0.498 0.344 0.54 27 0.404 P14672 I385T Polymorphism NA 0.434 0.26 19 0.428 P14672 V383I Disease NA 0.175 0.35 -12 0.197 P14678 S79P Polymorphism 0.759 0.968 0.05 33 0.862 P14679 C36Y Disease 0.982 0.940 0.00 54 0.970 P14679 C55Y Disease 0.983 0.972 0.00 63 0.961 P14679 C89R Disease 0.975 0.980 0.00 66 0.959 P14679 D42G Disease 0.571 0.500 0.14 21 0.527 P14679 G47D Disease 0.966 0.931 0.00 58 0.963 P14679 G47V Disease 0.973 0.864 0.00 44 0.937 P14679 G97R Disease 0.975 0.912 0.00 70 0.952 P14679 H19Q Disease 0.070 0.100 1.00 -5 0.059 P14679 P21S Disease 0.262 0.837 0.00 32 0.588 P14679 P81L Disease 0.974 0.927 0.00 28 0.945 P14679 Q68H Disease 0.693 0.892 0.22 7 0.694 P14679 R77Q Disease 0.932 0.965 0.00 45 0.921 P14679 R77W Disease 0.987 0.974 0.00 51 0.957 P14679 S44G Disease 0.355 0.305 0.49 7 0.299 P14679 S44R Disease 0.496 0.551 0.06 35 0.758 P14679 S79L Disease 0.309 0.621 0.32 -17 0.441 P14679 W80R Disease 0.975 0.957 0.00 41 0.941 P14679 A201S Disease 0.388 0.791 0.97 -11 0.459 P14679 A206T Disease 0.228 0.710 0.02 49 0.743 P14679 A355E Disease 0.363 0.345 0.30 33 0.417 P14679 A355P Disease 0.434 0.433 0.31 22 0.527 P14679 A416S Disease 0.282 0.888 0.07 44 0.570 P14679 C289G Disease 0.932 0.933 0.16 55 0.924 P14679 C289R Disease 0.972 0.931 0.01 67 0.938 P14679 D199N Disease 0.514 0.945 0.05 56 0.726 P14679 D240V Disease 0.744 0.651 0.19 26 0.781 P14679 D383N Disease 0.392 0.926 0.00 56 0.868 P14679 D444G Disease 0.245 0.572 0.08 53 0.720 P14679 D448N Disease 0.227 0.318 0.39 25 0.342 P14679 E294G Disease 0.491 0.485 0.30 29 0.452 P14679 E328Q Disease 0.451 0.323 0.04 44 0.560 P14679 E345G Disease 0.912 0.916 0.01 49 0.940 P14679 E398A Disease 0.396 0.546 0.26 12 0.445 P14679 E398V Disease 0.556 0.692 0.01 34 0.660 P14679 E409D Disease 0.101 0.198 1.00 -20 0.118 P14679 F134C Polymorphism 0.980 0.930 0.00 48 0.935 P14679 F176I Disease 0.938 0.935 0.01 43 0.905 P14679 F439V Disease 0.393 0.906 0.01 49 0.688 P14679 G109R Disease 0.975 0.945 0.00 56 0.954 P14679 G253R Disease 0.975 0.950 0.00 60 0.960 P14679 G346E Disease 0.388 0.951 0.00 61 0.901 P14679 G419R Disease 0.967 0.877 0.02 57 0.948 P14679 G446S Disease 0.456 0.849 0.00 49 0.871 P14679 H180N Disease 0.966 0.948 0.00 64 0.963 P14679 H256Y Disease 0.392 0.374 0.12 51 0.496 P14679 H390D Disease 0.436 0.961 0.00 82 0.931 P14679 H404N Disease 0.350 0.712 0.18 40 0.576 P14679 K142N Polymorphism 0.935 0.971 0.00 33 0.910 P14679 K243T Disease 0.128 0.340 0.20 -4 0.151 P14679 L216M Disease 0.492 0.758 0.01 15 0.577 P14679 L288S Disease 0.628 0.848 0.00 38 0.856 P14679 M179L Disease 0.217 0.737 0.76 -9 0.392 P14679 M332T Disease 0.451 0.264 0.11 40 0.363 P14679 M370T Disease 0.418 0.338 0.01 43 0.465 P14679 M426K Disease 0.465 0.926 0.00 60 0.918 P14679 N371T Disease 0.925 0.703 0.02 69 0.933 P14679 N371Y Disease 0.965 0.843 0.01 71 0.945 P14679 N382K Disease 0.374 0.932 0.00 46 0.802 P14679 N435D Disease 0.867 0.787 0.00 52 0.767 P14679 P152S Disease 0.199 0.510 0.24 -50 0.334 P14679 P205T Disease 0.350 0.917 0.01 59 0.910 P14679 P406L Disease 0.319 0.612 0.01 23 0.660 P14679 P417H Disease 0.766 0.826 0.00 56 0.902 P14679 P431L Disease 0.965 0.900 0.00 46 0.940 P14679 Q378K Disease 0.157 0.357 0.49 53 0.475 P14679 Q408H Disease 0.181 0.162 0.16 26 0.262 P14679 R217G Disease 0.136 0.413 0.38 10 0.299 P14679 R217Q Disease 0.112 0.224 0.39 -19 0.138 P14679 R217S Disease 0.077 0.307 0.50 1 0.136 P14679 R217W Disease 0.267 0.431 0.19 -18 0.190 P14679 R239W Disease 0.897 0.833 0.01 45 0.890 P14679 R299H Disease 0.959 0.935 0.00 59 0.957 P14679 R299S Disease 0.943 0.962 0.00 51 0.953 P14679 R308T Polymorphism 0.379 0.343 0.14 37 0.420 P14679 R402G Disease 0.525 0.915 0.01 31 0.659 P14679 R402L Disease 0.498 0.952 0.01 13 0.626 P14679 R403S Disease 0.315 0.954 0.01 46 0.769 P14679 R405L Disease 0.263 0.598 0.31 -3 0.442 P14679 R422Q Disease 0.213 0.787 0.07 52 0.535 P14679 R434I Disease 0.619 0.531 0.07 48 0.727 P14679 S329P Disease 0.447 0.684 0.07 16 0.549 P14679 S339G Disease 0.855 0.568 0.19 62 0.737 P14679 S361R Disease 0.237 0.465 0.01 64 0.366 P14679 S380P Disease 0.524 0.955 0.02 62 0.925 P14679 S395N Disease 0.420 0.277 0.06 26 0.356 P14679 S395R Disease 0.468 0.380 0.10 40 0.334 P14679 S424F Disease 0.276 0.289 0.57 9 0.224 P14679 T155S Disease 0.405 0.880 0.29 14 0.618 P14679 T325A Disease 0.276 0.107 0.77 16 0.202 P14679 T373K Disease 0.163 0.722 0.03 68 0.741 P14679 V177F Disease 0.933 0.954 0.00 54 0.949 P14679 V275F Disease 0.399 0.526 0.02 40 0.630 P14679 V318E Disease 0.635 0.919 0.00 70 0.925 P14679 V393F Disease 0.416 0.589 0.03 50 0.736 P14679 V427G Disease 0.924 0.905 0.03 42 0.909 P14679 W236L Disease 0.959 0.954 0.00 60 0.963 P14679 W236S Disease 0.977 0.970 0.00 58 0.963 P14679 W272C Disease 0.985 0.848 0.00 64 0.955 P14679 W400L Disease 0.457 0.926 0.01 53 0.897 P14770 L7P Disease NA 0.526 0.01 59 0.733 P14770 C24R Disease 0.741 0.653 0.01 60 0.877 P14770 D37G Disease 0.553 0.703 0.01 24 0.778 P14770 F71S Disease 0.329 0.333 0.00 46 0.572 P14770 L56P Disease 0.905 0.634 0.00 69 0.923 P14770 N61S Disease 0.698 0.414 0.00 66 0.881 P14770 A156T Disease 0.160 0.217 0.32 -4 0.151 P14770 C113Y Disease 0.921 0.810 0.00 65 0.938 P14778 A124G Polymorphism 0.115 0.070 0.18 -16 0.122 P14780 A20V Polymorphism NA 0.160 0.50 -65 0.133 P14780 E82K Polymorphism 0.290 0.745 0.20 43 0.575 P14780 F571V Polymorphism 0.625 0.579 0.00 32 0.586 P14780 N127K Polymorphism 0.431 0.926 0.12 61 0.774 P14780 Q279R Polymorphism NA 0.473 0.15 16 0.392 P14784 S83F Polymorphism 0.658 0.103 0.80 16 0.094 P14784 D391E Polymorphism 0.055 0.060 1.00 -34 0.025 P14867 A322D Disease 0.818 0.888 0.02 37 0.810 P14902 A4T Polymorphism NA 0.055 NA -13 0.038 P14923 M697L Polymorphism 0.057 0.182 0.13 -15 0.094 P15056 A246P Disease NA 0.860 0.03 63 0.901 P15056 D594G Disease 0.876 0.940 0.00 64 0.929 P15056 D638E Disease 0.778 0.830 0.00 54 0.900 P15056 E275K Disease NA 0.205 1.00 8 0.158 P15056 E501G Disease 0.879 0.897 0.00 71 0.917 P15056 E501K Disease 0.876 0.948 0.00 79 0.923 P15056 F468S Disease 0.827 0.797 0.16 54 0.744 P15056 F595L Disease 0.781 0.868 0.00 61 0.777 P15056 G464E Disease 0.946 0.936 0.00 73 0.929 P15056 G466V Disease 0.999 0.903 0.00 74 0.943 P15056 G469A Disease 0.887 0.870 0.01 49 0.834 P15056 G469E Disease 0.946 0.928 0.00 76 0.927 P15056 G469R Disease 0.958 0.919 0.00 76 0.936 P15056 G596V Disease 0.872 0.908 0.00 60 0.920 P15056 I463S Disease 0.777 0.739 0.00 59 0.899 P15056 K499E Disease 0.329 0.484 0.15 10 0.399 P15056 K499N Disease 0.411 0.408 0.11 23 0.426 P15056 K601E Disease 0.660 0.526 0.07 20 0.755 P15056 K601Q Disease 0.653 0.374 0.10 11 0.576 P15056 L245F Disease NA 0.816 0.04 62 0.883 P15056 L485F Disease 0.664 0.785 0.03 3 0.644 P15056 L525P Disease 0.706 0.893 0.05 22 0.769 P15056 L597R Disease 0.856 0.940 0.00 54 0.921 P15056 N581D Disease 0.826 0.897 0.00 70 0.920 P15056 P301S Polymorphism NA 0.257 0.61 -22 0.188 P15056 Q257R Disease NA 0.416 0.46 46 0.589 P15056 Q709R Disease 0.534 0.462 0.04 35 0.626 P15056 R462I Disease 0.867 0.419 0.09 42 0.659 P15056 S467A Disease 0.494 0.415 0.25 -12 0.286 P15056 T599R Disease 0.779 0.236 1.00 14 0.515 P15085 A208T Polymorphism 0.277 0.568 0.32 -16 0.290 P15085 H276R Polymorphism 0.116 0.657 0.40 0 0.082 P15088 A81S Polymorphism 0.123 0.176 0.11 -51 0.109 P15104 R324C Disease 0.949 0.964 0.00 69 0.945 P15104 R341C Disease 0.958 0.965 0.03 60 0.949 P15121 I15F Polymorphism 0.509 0.582 0.04 -6 0.473 P15121 L73V Polymorphism 0.541 0.443 0.11 -17 0.578 P15121 G204S Polymorphism 0.650 0.815 0.24 27 0.739 P15121 T288I Polymorphism NA 0.289 0.19 -44 0.289 P15144 R86Q Polymorphism NA 0.151 0.14 -21 0.151 P15144 D242Y Polymorphism 0.519 0.474 0.04 32 0.638 P15144 I603M Polymorphism 0.303 0.125 0.11 -7 0.225 P15144 S752N Polymorphism 0.138 0.209 0.66 -37 0.148 P15151 A67T Polymorphism 0.080 0.158 0.28 -20 0.085 P15153 D57N Disease 0.348 0.922 0.00 67 0.918 P15169 G178D Disease 0.538 0.904 0.11 32 0.655 P15248 T117M Polymorphism NA 0.055 NA 43 0.055 P15259 E89A Disease 0.801 0.808 0.00 67 0.917 P15259 G97D Disease 0.915 0.896 0.00 73 0.921 P15259 R90W Disease 0.609 0.927 0.00 55 0.820 P15260 C77Y Disease 0.866 0.828 0.00 63 0.940 P15260 I87T Disease 0.612 0.430 0.02 42 0.505 P15260 V61I Polymorphism 0.291 0.274 0.23 34 0.245 P15260 L467P Polymorphism NA 0.646 NA -6 0.424 P15289 A18D Disease 0.493 0.754 0.64 -43 0.488 P15289 D29N Disease 0.998 0.887 0.00 79 0.932 P15289 D30H Disease 0.960 0.880 0.12 73 0.925 P15289 G32S Disease 0.931 0.856 0.00 53 0.921 P15289 G86D Disease 0.442 0.869 0.00 57 0.734 P15289 G99D Disease 0.975 0.887 0.00 51 0.915 P15289 G99V Disease 0.981 0.832 0.00 46 0.905 P15289 L68P Disease 0.685 0.868 0.00 46 0.880 P15289 P82L Disease 0.312 0.760 0.00 49 0.824 P15289 P94A Disease 0.500 0.427 0.26 24 0.354 P15289 R84Q Disease 0.956 0.870 0.00 66 0.930 P15289 R84W Disease 0.991 0.933 0.00 66 0.945 P15289 S95N Disease 0.374 0.178 0.19 -27 0.169 P15289 S96F Disease 0.683 0.485 0.05 33 0.696 P15289 S96L Disease 0.535 0.422 0.25 23 0.541 P15289 A212P Disease 0.590 0.595 0.81 14 0.440 P15289 A212V Disease 0.429 0.320 0.23 15 0.382 P15289 A224V Disease 0.429 0.398 0.03 39 0.585 P15289 A314T Disease 0.387 0.342 0.12 -12 0.298 P15289 A464V Polymorphism 0.290 0.483 0.26 -5 0.365 P15289 A469G Disease 0.333 0.719 0.04 -22 0.516 P15289 C156R Disease 0.713 0.637 0.33 54 0.768 P15289 C172Y Disease NA 0.201 0.29 -24 0.167 P15289 C294Y Disease 0.768 0.563 0.20 11 0.130 P15289 C300F Disease 0.721 0.811 0.06 46 0.872 P15289 C489G Disease 0.545 0.918 0.04 30 0.791 P15289 D152Y Disease 0.772 0.489 1.00 44 0.734 P15289 D169N Disease NA 0.291 0.36 -7 0.281 P15289 D255H Disease 0.978 0.926 0.12 72 0.909 P15289 D281Y Disease 0.999 0.937 0.00 79 0.911 P15289 D335V Disease 0.991 0.844 0.00 74 0.945 P15289 D381E Disease NA 0.266 0.34 -31 0.278 P15289 E253K Disease 0.409 0.809 0.00 39 0.692 P15289 E312D Disease 0.313 0.537 0.03 52 0.709 P15289 E382K Disease 0.145 0.305 0.19 5 0.253 P15289 F219V Disease 0.960 0.701 0.00 60 0.930 P15289 F247S Disease 0.607 0.360 0.00 44 0.635 P15289 F356V Polymorphism 0.073 0.085 0.56 -19 0.090 P15289 G119R Disease 0.465 0.926 0.03 67 0.927 P15289 G122S Disease 0.998 0.929 0.00 65 0.947 P15289 G154D Disease 0.640 0.340 0.39 29 0.563 P15289 G245R Disease 0.713 0.627 0.00 34 0.654 P15289 G293D Disease NA 0.753 0.00 37 0.581 P15289 G293S Disease NA 0.567 0.00 21 0.514 P15289 G308D Disease 0.983 0.917 0.00 66 0.929 P15289 G308V Disease 0.987 0.877 0.00 63 0.929 P15289 G309S Disease 0.514 0.892 0.00 44 0.588 P15289 G325S Disease 0.514 0.790 0.00 38 0.568 P15289 H227Y Disease 0.506 0.213 0.04 66 0.548 P15289 H397Y Disease 0.506 0.345 0.05 2 0.525 P15289 I179S Disease NA 0.494 0.12 6 0.450 P15289 K302N Disease 0.913 0.862 0.41 37 0.873 P15289 K367N Disease 0.292 0.435 0.13 14 0.339 P15289 L135P Disease 0.762 0.832 0.06 22 0.824 P15289 L181Q Disease NA 0.518 0.05 8 0.552 P15289 L298S Disease 0.630 0.594 0.38 52 0.879 P15289 L428P Disease 0.933 0.904 0.00 49 0.929 P15289 N282S Disease 0.399 0.901 0.12 69 0.880 P15289 P136L Disease 0.987 0.904 0.00 31 0.939 P15289 P136S Disease 0.979 0.792 0.00 32 0.872 P15289 P148L Disease 0.664 0.348 0.00 5 0.593 P15289 P155L Disease 0.664 0.500 0.30 24 0.751 P15289 P155R Disease 0.683 0.654 0.52 41 0.767 P15289 P167R Disease NA 0.700 0.62 5 0.454 P15289 P191T Disease 0.927 0.284 0.27 18 0.597 P15289 P231T Disease 0.605 0.604 0.02 -13 0.513 P15289 P377L Disease 0.664 0.179 0.16 1 0.400 P15289 P425T Disease 0.901 0.550 0.11 7 0.822 P15289 P426L Disease 0.962 0.500 0.00 10 0.741 P15289 Q153H Disease 0.610 0.308 0.13 -6 0.482 P15289 Q190H Disease 0.610 0.229 0.53 14 0.536 P15289 R143G Disease 0.410 0.238 0.26 10 0.369 P15289 R217H Disease 0.417 0.500 0.18 31 0.458 P15289 R244C Disease 0.825 0.720 0.03 45 0.839 P15289 R244H Disease 0.640 0.577 0.60 -2 0.503 P15289 R288C Disease NA 0.627 0.08 34 0.767 P15289 R288H Disease NA 0.326 0.23 -9 0.354 P15289 R311Q Disease 0.966 0.888 0.00 71 0.914 P15289 R370Q Disease 0.470 0.600 0.15 36 0.517 P15289 R370W Disease 0.869 0.834 0.01 53 0.913 P15289 R384C Disease 0.667 0.607 0.04 32 0.759 P15289 R390Q Disease 0.839 0.891 0.48 71 0.897 P15289 R390W Disease 0.972 0.919 0.03 71 0.945 P15289 R496H Polymorphism 0.111 0.180 0.32 15 0.076 P15289 S250Y Disease 0.642 0.545 0.07 8 0.615 P15289 S295Y Disease 0.701 0.536 0.01 -6 0.721 P15289 T274M Disease 0.999 0.912 0.00 59 0.936 P15289 T286P Disease NA 0.611 0.15 16 0.440 P15289 T327I Disease 0.481 0.285 0.90 -3 0.254 P15289 T391S Polymorphism 0.083 0.114 0.93 -6 0.066 P15289 T408I Disease 0.396 0.112 0.49 0 0.207 P15289 T409I Disease NA 0.116 0.34 -5 0.202 P15289 W193C Polymorphism 0.672 0.722 0.10 3 0.716 P15289 Y201C Disease 0.815 0.859 0.03 47 0.840 P15289 Y306H Disease 0.400 0.500 0.00 64 0.593 P15289 Y376N Disease 0.913 0.578 0.00 28 0.781 P15289 Y429S Disease 0.524 0.768 0.00 53 0.857 P15291 H257R Polymorphism 0.066 0.191 1.00 -15 0.098 P15309 F124V Polymorphism 0.412 0.819 0.01 48 0.846 P15309 W226R Polymorphism 0.477 0.893 0.12 67 0.929 P15309 Y330H Polymorphism 0.459 0.431 0.02 15 0.414 P15311 A494P Polymorphism 0.305 0.249 0.14 25 0.334 P15311 L532V Polymorphism 0.168 0.109 0.11 -20 0.216 P15311 R180C Polymorphism 0.909 0.934 0.00 40 0.892 P15313 L81P Disease 0.841 0.794 0.01 45 0.880 P15313 T30I Polymorphism 0.068 0.270 0.33 -8 0.176 P15313 G123V Disease 0.851 0.909 0.00 63 0.931 P15313 G316E Disease 0.330 0.798 0.00 68 0.876 P15313 G364S Disease 0.724 0.583 0.18 39 0.802 P15313 M174R Disease 0.297 0.935 0.00 60 0.911 P15313 P346R Disease NA 0.877 0.01 55 0.892 P15313 R124W Disease 0.938 0.938 0.00 63 0.926 P15313 R157C Disease 0.914 0.855 0.00 76 0.926 P15313 R465H Disease NA 0.668 0.01 33 0.784 P15313 T275P Disease 0.496 0.739 0.02 31 0.799 P15328 W28R Polymorphism 0.413 0.125 0.62 18 0.100 P15382 T7I Disease 0.190 0.359 0.00 47 0.533 P15382 D76N Disease 0.506 0.316 0.05 36 0.351 P15382 G52A Polymorphism 0.512 0.814 0.00 21 0.509 P15382 L51H Disease 0.814 0.698 0.00 43 0.816 P15382 R32H Disease 0.421 0.070 0.00 11 0.118 P15382 R98W Disease 0.819 0.712 0.00 50 0.881 P15382 S38G Polymorphism 0.261 0.056 0.02 -4 0.042 P15382 S74L Disease 0.608 0.450 0.00 13 0.495 P15382 V47F Disease 0.358 0.189 0.02 38 0.193 P15382 W87R Disease 0.324 0.761 0.00 49 0.812 P15382 P127T Disease 0.261 0.073 0.00 14 0.121 P15382 V109I Disease 0.067 0.030 1.00 2 0.032 P15391 L174V Polymorphism 0.076 0.043 0.78 -5 0.039 P15391 R514H Polymorphism 0.093 0.164 0.45 37 0.064 P15428 A140P Disease 0.743 0.878 0.17 72 0.731 P15428 Y217C Polymorphism 0.568 0.527 0.10 -43 0.699 P15498 T739M Polymorphism 0.099 0.072 0.29 22 0.135 P15502 G610R Polymorphism NA 0.240 NA 49 0.095 P15509 G196R Disease 0.930 0.965 0.00 62 0.958 P15514 Y81C Polymorphism NA 0.553 0.00 43 0.725 P15529 R59Q Polymorphism 0.106 0.484 0.61 -4 0.085 P15529 D266N Polymorphism 0.352 0.473 0.38 -18 0.193 P15529 P165S Disease 0.986 0.477 0.02 56 0.884 P15529 S240P Disease 0.698 0.434 0.08 58 0.712 P15529 V355G Polymorphism 0.217 0.215 0.00 37 0.312 P15538 C10Y Polymorphism NA 0.357 0.70 33 0.510 P15538 P42S Disease 0.984 0.885 0.00 45 0.935 P15538 R43Q Polymorphism 0.257 0.175 0.61 -1 0.116 P15538 M160I Polymorphism 0.149 0.244 0.04 26 0.158 P15538 N133H Disease 0.757 0.342 0.02 -1 0.599 P15538 R374Q Disease 0.999 0.866 0.00 71 0.947 P15538 R404H Polymorphism 0.192 0.304 0.24 -28 0.028 P15538 R448H Disease 0.994 0.917 0.00 72 0.908 P15538 T248I Polymorphism 0.147 0.070 1.00 -17 0.050 P15538 T318M Disease 0.786 0.824 0.00 70 0.918 P15538 T319M Disease 0.778 0.770 0.00 50 0.888 P15559 Q269H Polymorphism NA 0.181 0.00 63 0.415 P15559 R139W Polymorphism NA 0.261 0.01 31 0.431 P15735 A317T Polymorphism 0.068 0.626 0.58 -22 0.276 P15735 D215N Disease 0.999 0.878 0.00 65 0.946 P15735 E157K Disease 0.660 0.937 0.01 39 0.865 P15735 G189E Disease 0.971 0.910 0.00 74 0.902 P15735 V106E Disease 0.832 0.788 0.00 65 0.897 P15812 G15E Polymorphism NA 0.271 0.45 -24 0.342 P15812 H102R Polymorphism NA 0.086 0.61 -5 0.126 P15812 Q106R Polymorphism NA 0.059 1.00 -18 0.039 P15814 P120L Polymorphism 0.252 0.726 0.17 1 0.427 P15822 P362L Polymorphism NA 0.043 0.06 38 0.083 P15822 A1520G Polymorphism NA 0.040 0.19 5 0.069 P15822 K1170N Polymorphism NA 0.041 0.46 26 0.070 P15822 M1609I Polymorphism NA 0.051 0.04 36 0.096 P15848 R95Q Disease 0.998 0.838 0.00 79 0.948 P15848 S65F Disease 0.890 0.856 0.02 21 0.854 P15848 T92M Disease 0.943 0.370 0.00 65 0.901 P15848 C117R Disease 0.190 0.521 0.70 29 0.222 P15848 C192R Disease NA 0.671 0.07 -4 0.468 P15848 C405Y Disease NA 0.231 1.00 -5 0.174 P15848 C521Y Disease 0.734 0.605 0.01 21 0.712 P15848 F399L Disease NA 0.255 0.14 17 0.357 P15848 G137V Disease 0.886 0.926 0.00 53 0.923 P15848 G144R Disease 0.998 0.893 0.00 73 0.947 P15848 G302R Disease 0.999 0.906 0.00 76 0.948 P15848 H393P Disease 0.625 0.677 0.03 46 0.822 P15848 L236P Disease 0.868 0.759 0.02 51 0.913 P15848 L321P Disease 0.185 0.831 0.11 19 0.367 P15848 L498P Disease 0.941 0.916 0.01 62 0.949 P15848 M142I Disease 0.139 0.403 0.34 15 0.257 P15848 P116H Disease 0.184 0.568 0.06 22 0.422 P15848 P531R Disease 0.142 0.852 0.00 32 0.703 P15848 Q239R Disease 0.440 0.305 0.46 55 0.587 P15848 R152W Disease 0.934 0.714 0.01 46 0.818 P15848 R160Q Disease 0.861 0.396 0.04 40 0.642 P15848 R315Q Disease 0.644 0.826 0.29 53 0.786 P15848 R484G Disease 0.568 0.297 0.56 32 0.598 P15848 S384N Disease 0.261 0.096 0.45 6 0.221 P15848 V376M Polymorphism 0.346 0.067 0.14 -7 0.163 P15848 W146L Disease 0.909 0.858 0.00 72 0.918 P15848 W146R Disease 0.950 0.907 0.00 79 0.909 P15848 W146S Disease 0.951 0.896 0.00 72 0.919 P15848 W312C Disease 0.847 0.785 0.06 55 0.923 P15848 Y210C Disease 0.963 0.944 0.07 67 0.945 P15882 L20F Disease NA 0.660 0.00 43 0.741 P15882 A223V Disease 0.549 0.494 0.33 54 0.784 P15882 E313K Disease 0.535 0.406 0.50 15 0.540 P15882 G228S Disease 0.758 0.940 0.02 57 0.870 P15882 I126M Disease NA 0.291 0.01 -6 0.221 P15882 P252Q Disease 0.821 0.481 0.65 61 0.810 P15882 Y143H Disease NA 0.481 0.12 -1 0.481 P15884 A610V Disease 0.861 0.855 0.00 48 0.898 P15884 D535G Disease 0.375 0.398 0.35 29 0.506 P15884 M450I Polymorphism 0.233 0.637 0.45 29 0.665 P15884 R572G Disease 0.909 0.877 0.00 53 0.927 P15884 R576Q Disease 0.882 0.890 0.00 65 0.939 P15884 R576W Disease 0.979 0.933 0.00 66 0.976 P15918 A156V Polymorphism NA 0.303 0.06 0 0.280 P15918 C328Y Disease NA 0.872 0.00 61 0.891 P15918 D429G Disease NA 0.644 0.00 35 0.736 P15918 D887N Polymorphism 0.205 0.478 0.01 19 0.427 P15918 E669G Disease 0.330 0.914 0.00 20 0.694 P15918 E722K Disease 0.246 0.944 0.00 34 0.627 P15918 K820R Polymorphism 0.142 0.290 0.02 16 0.247 P15918 L885R Disease 0.567 0.695 0.00 53 0.854 P15918 M435V Disease NA 0.254 0.01 18 0.385 P15918 R244G Polymorphism NA 0.691 0.02 44 0.735 P15918 R314W Disease NA 0.807 0.00 50 0.862 P15918 R396C Disease NA 0.940 0.00 56 0.892 P15918 R396H Disease NA 0.903 0.00 56 0.879 P15918 R396L Disease NA 0.876 0.00 58 0.885 P15918 R507W Disease NA 0.859 0.00 45 0.847 P15918 R559S Disease NA 0.914 0.00 48 0.864 P15918 R561C Disease NA 0.948 0.00 39 0.829 P15918 R561H Disease NA 0.922 0.00 43 0.830 P15918 R624C Disease 0.663 0.909 0.00 65 0.921 P15918 R624H Disease 0.291 0.857 0.00 66 0.894 P15918 R737H Disease 0.456 0.899 0.00 50 0.867 P15918 R778Q Disease 0.285 0.824 0.00 39 0.615 P15918 R975Q Disease 0.286 0.810 0.00 57 0.858 P15918 R975W Disease 0.750 0.895 0.00 57 0.900 P15918 S401P Disease NA 0.817 0.12 30 0.779 P15918 Y912C Disease 0.738 0.855 0.00 65 0.913 P15923 T198A Polymorphism 0.088 0.127 0.74 -13 0.043 P15924 I305F Polymorphism 0.456 0.582 0.03 -34 0.455 P15924 N287K Disease 0.390 0.886 0.00 1 0.757 P15924 S299R Disease 0.806 0.905 0.00 5 0.872 P15924 R1255K Disease NA 0.175 1.00 15 0.132 P15924 R1775I Disease NA 0.197 0.19 31 0.338 P15924 R2366C Disease NA 0.383 0.02 63 0.714 P15927 G15R Polymorphism 0.899 0.312 0.13 45 0.571 P15927 Y14S Polymorphism 0.167 0.339 0.77 0 0.201 P15941 S1142N Polymorphism 0.087 0.117 0.99 -18 0.070 P15976 D218G Disease 0.894 0.963 0.04 49 0.920 P15976 D218Y Disease 0.970 0.978 0.00 57 0.959 P15976 G208S Disease 0.917 0.956 0.00 51 0.941 P15976 R216Q Disease 0.899 0.975 0.01 56 0.951 P15976 V205M Disease 0.927 0.891 0.00 48 0.907 P16050 D90H Polymorphism 0.255 0.384 0.18 45 0.546 P16050 T560M Polymorphism 0.813 0.344 0.01 25 0.628 P16066 E967K Polymorphism 0.436 0.255 0.07 27 0.402 P16066 R939Q Polymorphism 0.215 0.402 0.65 -1 0.181 P16070 D494H Polymorphism 0.422 0.697 0.00 32 0.743 P16070 T393M Polymorphism 0.291 0.083 0.00 -8 0.156 P16083 K16R Polymorphism NA 0.271 0.79 -19 0.222 P16109 E542K Polymorphism 0.437 0.626 0.01 63 0.561 P16109 G179R Polymorphism 0.776 0.837 0.07 67 0.811 P16109 G631V Polymorphism 0.383 0.313 0.52 31 0.279 P16109 L640V Polymorphism 0.199 0.269 1.00 -53 0.148 P16109 P301L Polymorphism 0.239 0.344 0.09 29 0.335 P16109 S331N Polymorphism 0.099 0.186 0.65 30 0.172 P16109 S385L Polymorphism 0.062 0.196 0.37 18 0.201 P16109 S500F Polymorphism 0.452 0.256 0.09 41 0.489 P16109 S619A Polymorphism 0.206 0.229 0.08 24 0.291 P16109 T661N Polymorphism 0.244 0.480 0.81 0 0.179 P16109 T756P Polymorphism 0.442 0.373 0.30 20 0.255 P16109 V209M Polymorphism NA 0.550 0.02 45 0.692 P16112 R275Q Polymorphism 0.247 0.335 0.14 5 0.351 P16112 P1943L Polymorphism NA 0.140 0.15 44 0.148 P16144 C38R Disease NA 0.874 0.00 60 0.902 P16144 C61Y Disease NA 0.946 0.00 51 0.899 P16144 C245G Disease 0.913 0.931 0.00 33 0.872 P16144 C562R Disease 0.962 0.943 0.00 81 0.953 P16144 D131Y Disease 0.968 0.932 0.00 52 0.948 P16144 G273D Disease 0.549 0.946 0.01 70 0.930 P16144 G931D Disease 0.549 0.340 NA 68 0.670 P16144 L156P Disease 0.959 0.965 0.00 46 0.921 P16144 L336P Disease 0.698 0.933 0.00 59 0.930 P16144 R252C Disease 0.769 0.970 0.00 47 0.894 P16144 R283C Disease 0.769 0.870 0.04 24 0.869 P16144 V325D Disease 0.953 0.869 0.00 24 0.902 P16144 R1225H Disease NA 0.349 0.07 46 0.374 P16144 R1281W Disease NA 0.695 0.01 54 0.839 P16144 T1764S Polymorphism NA 0.124 0.23 38 0.120 P16150 T22I Polymorphism NA 0.208 NA 54 0.086 P16152 V88I Polymorphism 0.207 0.560 1.00 13 0.408 P16157 L276R Disease 0.934 0.256 0.00 75 0.922 P16157 L733I Polymorphism 0.229 0.530 0.40 -6 0.150 P16157 V463I Disease 0.126 0.228 0.09 -13 0.217 P16157 V750A Polymorphism 0.301 0.672 0.09 16 0.403 P16157 V991L Polymorphism NA 0.678 0.06 -20 0.483 P16157 A1126P Polymorphism NA 0.968 0.00 34 0.864 P16157 I1054T Disease NA 0.957 0.00 40 0.864 P16157 M1325V Polymorphism NA 0.250 0.00 1 0.108 P16157 T1075I Polymorphism NA 0.152 0.03 2 0.238 P16157 T1192P Polymorphism NA 0.978 0.00 40 0.867 P16157 V1546I Polymorphism NA 0.141 NA -43 0.098 P16188 H21Q Polymorphism 0.512 0.359 0.55 -58 0.005 P16188 R89G Polymorphism 0.477 0.715 0.06 17 0.530 P16188 S33Y Polymorphism 0.320 0.380 1.00 -18 0.285 P16188 T55A Polymorphism 0.452 0.725 0.03 -3 0.667 P16188 D101N Polymorphism 0.347 0.244 1.00 -31 0.235 P16188 F133L Polymorphism 0.259 0.265 0.86 -28 0.299 P16188 I121M Polymorphism 0.221 0.335 0.26 -25 0.193 P16188 I166T Polymorphism 0.408 0.762 0.59 27 0.687 P16188 N151K Polymorphism 0.576 0.954 0.03 44 0.775 P16188 S129P Polymorphism 0.261 0.581 0.91 -45 0.404 P16189 A114D Polymorphism 0.200 0.855 0.53 -5 0.483 P16189 I166T Polymorphism 0.408 0.757 0.50 30 0.663 P16189 M121I Polymorphism 0.221 0.702 0.45 17 0.294 P16189 N151K Polymorphism 0.576 0.954 0.03 53 0.782 P16189 Q138R Polymorphism 0.243 0.520 0.60 -6 0.230 P16190 M358V Polymorphism 0.274 0.091 1.00 6 0.096 P16219 G90S Disease NA 0.884 0.07 72 0.866 P16219 G92C Disease NA 0.868 0.01 60 0.855 P16219 R46W Disease NA 0.901 0.17 46 0.878 P16219 A192V Disease 0.965 0.869 0.02 53 0.917 P16219 R107C Disease 0.881 0.855 0.05 44 0.881 P16219 R325W Disease 0.983 0.912 0.00 53 0.862 P16219 R380W Disease 0.990 0.936 0.00 60 0.930 P16219 R383C Disease 0.941 0.819 0.04 69 0.912 P16219 R383H Polymorphism 0.943 0.799 0.02 65 0.915 P16219 S353L Disease 0.949 0.737 0.08 33 0.854 P16219 W177R Disease 0.961 0.886 0.00 61 0.928 P16234 G79D Polymorphism 0.294 0.714 0.12 43 0.546 P16234 G426D Polymorphism NA 0.334 0.30 -16 0.309 P16234 R764C Polymorphism NA 0.678 0.09 51 0.813 P16234 S478P Polymorphism 0.033 0.462 0.40 -15 0.156 P16278 I51T Disease NA 0.564 0.01 45 0.795 P16278 R49C Disease 0.801 0.519 0.07 38 0.782 P16278 R59C Disease 0.995 0.883 0.00 65 0.949 P16278 R59H Disease 0.991 0.889 0.00 60 0.949 P16278 R68W Disease 0.909 0.814 0.00 46 0.888 P16278 T82M Disease 0.756 0.734 0.13 30 0.766 P16278 Y83H Disease 0.864 0.874 0.00 66 0.824 P16278 D151Y Disease 0.585 0.718 0.13 57 0.675 P16278 D214Y Disease 0.793 0.645 0.14 18 0.777 P16278 D332N Disease 0.955 0.773 0.00 55 0.934 P16278 D491N Disease 0.818 0.535 0.02 14 0.735 P16278 D491Y Disease 0.980 0.659 0.00 57 0.920 P16278 E632G Disease NA 0.201 0.06 28 0.311 P16278 G123R Disease 0.994 0.904 0.00 68 0.927 P16278 G134V Disease 0.989 0.840 0.00 58 0.939 P16278 G272D Disease 0.912 0.819 0.00 73 0.917 P16278 G438E Disease 0.384 0.469 0.46 16 0.391 P16278 G494C Disease 0.990 0.912 0.00 58 0.955 P16278 G579D Disease 0.866 0.829 0.00 67 0.929 P16278 H281Y Disease 0.834 0.621 0.44 31 0.803 P16278 K578R Disease 0.852 0.422 0.14 42 0.474 P16278 L155R Disease 0.936 0.788 0.04 -10 0.814 P16278 L162S Disease 0.613 0.506 0.04 9 0.719 P16278 N266S Disease 0.463 0.231 0.59 19 0.328 P16278 N484K Disease 0.636 0.669 0.01 73 0.893 P16278 P263S Disease 0.968 0.745 0.03 44 0.897 P16278 P549L Disease 0.763 0.585 0.30 47 0.832 P16278 Q408P Disease 0.809 0.591 0.28 11 0.698 P16278 R109W Polymorphism 0.923 0.689 0.02 9 0.786 P16278 R121S Disease 0.973 0.858 0.00 58 0.934 P16278 R148S Disease 0.990 0.817 0.00 65 0.939 P16278 R201C Disease 0.797 0.468 0.04 31 0.695 P16278 R201H Disease 0.587 0.370 0.20 4 0.564 P16278 R208C Disease 0.896 0.638 0.09 12 0.799 P16278 R457Q Disease 0.541 0.532 0.16 28 0.526 P16278 R482C Disease 0.952 0.890 0.00 69 0.944 P16278 R482H Disease 0.452 0.836 0.01 31 0.674 P16278 R521C Polymorphism 0.821 0.580 0.08 32 0.787 P16278 R590C Disease 0.974 0.896 0.00 68 0.951 P16278 R590H Disease 0.898 0.855 0.00 68 0.935 P16278 T239M Disease 0.868 0.568 0.02 39 0.817 P16278 T500A Disease 0.478 0.170 0.56 14 0.308 P16278 V216A Disease 0.386 0.410 0.01 -19 0.325 P16278 V240M Disease 0.711 0.315 0.01 2 0.618 P16278 W273L Disease 0.824 0.820 0.00 65 0.926 P16278 W509C Disease 0.921 0.751 0.02 74 0.928 P16278 Y270D Disease 0.847 0.567 0.00 66 0.919 P16278 Y316C Disease 0.849 0.726 0.03 36 0.824 P16278 Y591C Disease 0.919 0.845 0.01 65 0.931 P16278 Y591N Disease 0.546 0.638 0.01 61 0.815 P16284 L125V Polymorphism NA 0.041 0.96 -35 0.062 P16333 A180V Polymorphism 0.322 0.287 0.29 23 0.319 P16402 E75K Polymorphism 0.500 0.834 0.01 -3 0.541 P16403 S113A Polymorphism 0.203 0.271 0.31 -18 0.202 P16410 T17A Polymorphism 0.079 0.058 0.06 -62 0.057 P16415 R566H Polymorphism 0.298 0.720 0.62 -8 0.183 P16422 M115T Polymorphism 0.217 0.063 0.82 -16 0.015 P16435 A284P Disease 0.831 0.817 0.02 34 0.837 P16435 A500V Polymorphism NA 0.219 0.26 -17 0.283 P16435 C566Y Disease 0.950 0.814 0.00 65 0.919 P16435 R454H Disease 0.986 0.902 0.00 73 0.937 P16435 V489E Disease 0.939 0.807 0.00 66 0.919 P16435 V605F Disease 0.933 0.874 0.00 68 0.922 P16435 Y178D Disease 0.952 0.950 0.00 73 0.933 P16435 Y575C Disease 0.985 0.648 0.00 32 0.888 P16442 G35R Polymorphism 0.281 0.355 0.13 55 0.268 P16442 P74S Polymorphism 0.226 0.253 0.63 -22 0.218 P16442 V36F Polymorphism 0.104 0.074 0.61 -31 0.050 P16442 D291N Polymorphism 0.596 0.877 0.00 43 0.867 P16442 G235S Polymorphism 0.280 0.626 0.61 35 0.482 P16442 K346M Polymorphism 0.742 0.810 0.00 48 0.873 P16442 L266M Polymorphism 0.243 0.309 0.22 33 0.224 P16442 M288R Polymorphism 0.586 0.629 0.01 37 0.783 P16442 P156L Polymorphism 0.252 0.737 0.79 6 0.410 P16442 R161H Polymorphism 0.423 0.158 0.54 -45 0.130 P16442 R176G Polymorphism 0.243 0.500 0.40 23 0.406 P16442 R198W Polymorphism 0.762 0.165 0.05 11 0.484 P16442 R352G Polymorphism 0.612 0.826 0.00 27 0.829 P16442 R352W Polymorphism 0.844 0.853 0.00 34 0.881 P16442 V277M Polymorphism 0.511 0.777 0.01 17 0.591 P16452 A112T Disease NA 0.882 0.00 51 0.742 P16452 D145Y Disease 0.792 0.970 0.00 63 0.945 P16452 R280Q Disease 0.975 0.932 0.00 64 0.957 P16452 R287C Disease 0.993 0.970 0.00 67 0.955 P16455 L53F Polymorphism NA 0.617 0.39 0 0.435 P16455 P58S Polymorphism 0.235 0.543 0.83 0 0.371 P16455 E166D Polymorphism 0.572 0.657 0.22 -2 0.587 P16455 I143V Polymorphism 0.239 0.357 0.72 11 0.318 P16455 K178R Polymorphism 0.381 0.242 0.22 -7 0.259 P16473 C41S Disease 0.946 0.560 0.90 13 0.692 P16473 E34K Polymorphism 0.322 0.248 0.72 17 0.319 P16473 P52T Polymorphism 0.506 0.168 0.52 -36 0.206 P16473 A553T Disease 0.755 0.874 0.01 31 0.848 P16473 A647V Disease NA 0.913 0.01 37 0.680 P16473 A703G Polymorphism NA 0.807 0.12 45 0.698 P16473 C390W Disease 0.852 0.936 0.00 52 0.922 P16473 C600R Disease NA 0.905 0.01 68 0.914 P16473 C672Y Disease NA 0.932 0.00 53 0.890 P16473 D410N Disease 0.866 0.934 0.32 25 0.827 P16473 D633E Disease NA 0.943 0.01 54 0.854 P16473 D727E Polymorphism NA 0.143 1.00 -12 0.211 P16473 F525L Disease 0.239 0.563 0.26 23 0.461 P16473 F631L Disease NA 0.834 0.00 30 0.654 P16473 G431S Disease 0.965 0.824 0.09 29 0.855 P16473 G498S Disease 0.263 0.908 0.01 36 0.567 P16473 I167N Disease 0.611 0.853 0.00 62 0.898 P16473 I486F Disease 0.824 0.724 0.08 25 0.806 P16473 I486M Disease 0.807 0.647 0.09 43 0.795 P16473 I568T Disease 0.404 0.748 0.00 56 0.710 P16473 I606M Polymorphism NA 0.528 0.21 -14 0.451 P16473 K183R Disease 0.221 0.277 0.48 -35 0.227 P16473 L252P Disease 0.955 0.959 0.00 64 0.952 P16473 L467P Disease 0.981 0.982 0.00 53 0.950 P16473 L629F Disease NA 0.823 0.01 49 0.865 P16473 M453T Disease 0.859 0.855 0.00 49 0.882 P16473 M463V Disease 0.220 0.947 0.02 30 0.572 P16473 N650Y Disease NA 0.514 0.03 35 0.776 P16473 N670S Disease NA 0.916 0.03 55 0.848 P16473 P162A Disease NA 0.303 0.14 11 0.365 P16473 P639S Disease NA 0.917 0.00 57 0.905 P16473 Q720E Polymorphism NA 0.096 0.84 21 0.096 P16473 R109Q Disease 0.344 0.337 0.47 3 0.299 P16473 R310C Disease 0.107 0.813 0.05 23 0.612 P16473 R450H Disease 0.914 0.840 0.01 65 0.955 P16473 R528H Polymorphism 0.572 0.581 0.42 -16 0.440 P16473 S281N Disease 0.838 0.626 0.09 40 0.775 P16473 S505N Disease 0.421 0.911 0.01 32 0.746 P16473 S505R Disease 0.469 0.937 0.00 51 0.889 P16473 T477I Disease 0.874 0.768 0.03 46 0.840 P16473 T632A Disease NA 0.925 0.00 48 0.710 P16473 T632I Disease NA 0.955 0.00 37 0.777 P16473 V509A Disease 0.320 0.896 0.01 32 0.705 P16473 V597F Disease NA 0.784 0.01 42 0.830 P16499 A145T Polymorphism NA 0.845 0.01 51 0.880 P16499 G850V Polymorphism 0.059 0.244 0.12 12 0.262 P16499 K827Q Polymorphism 0.311 0.213 0.60 -5 0.231 P16499 N216S Polymorphism NA 0.288 0.80 7 0.369 P16499 P293L Polymorphism NA 0.427 0.15 43 0.594 P16499 Q492H Polymorphism NA 0.269 0.10 38 0.395 P16499 Q569K Disease 0.742 0.938 0.05 50 0.914 P16499 R102H Disease NA 0.567 0.08 7 0.666 P16499 R102S Disease NA 0.639 0.63 42 0.533 P16499 S344R Disease NA 0.435 0.18 21 0.356 P16499 S573P Disease 0.488 0.854 0.11 44 0.840 P16520 V40M Polymorphism 0.456 0.142 0.22 6 0.253 P16520 V81M Polymorphism 0.732 0.249 0.13 1 0.564 P16520 G324E Polymorphism 0.927 0.704 0.00 58 0.967 P16520 L280F Polymorphism 0.329 0.549 0.37 -19 0.279 P16520 W339L Polymorphism 0.886 0.588 0.01 60 0.976 P16581 E295K Polymorphism 0.114 0.308 0.31 -3 0.149 P16581 H468Y Polymorphism 0.200 0.245 1.00 44 0.174 P16581 P550S Polymorphism 0.342 0.686 0.09 6 0.259 P16581 Q257P Polymorphism 0.231 0.500 0.31 3 0.142 P16581 S149R Polymorphism 0.614 0.679 0.01 29 0.663 P16591 M412V Polymorphism 0.263 0.082 0.16 -1 0.069 P16615 G23E Disease 0.998 0.961 0.00 76 0.941 P16615 L65S Disease 0.972 0.876 0.00 41 0.885 P16615 N39T Disease 0.998 0.870 0.00 68 0.942 P16615 A745D Disease 0.960 0.943 0.00 51 0.923 P16615 A803T Disease 0.607 0.849 0.09 33 0.583 P16615 A838P Disease NA 0.891 0.06 -1 0.774 P16615 C268F Disease 0.836 0.848 0.01 26 0.848 P16615 C318R Disease 0.891 0.841 0.00 57 0.927 P16615 C560R Disease 0.797 0.844 0.00 63 0.922 P16615 C875G Disease NA 0.572 0.15 67 0.719 P16615 D702N Disease 0.930 0.918 0.00 71 0.918 P16615 E412G Disease 0.550 0.457 0.26 15 0.584 P16615 F675S Disease 0.402 0.710 0.00 53 0.837 P16615 G211D Disease 0.843 0.955 0.00 70 0.878 P16615 G310V Disease 0.878 0.872 0.00 34 0.856 P16615 G749R Disease 0.979 0.904 0.00 66 0.927 P16615 G769R Disease 0.887 0.864 0.00 60 0.913 P16615 H943R Disease NA 0.759 0.03 19 0.775 P16615 I348T Disease 0.710 0.837 0.00 53 0.894 P16615 K683E Disease 0.929 0.927 0.00 64 0.933 P16615 N767S Disease 0.668 0.848 0.23 39 0.651 P16615 P160L Disease 0.857 0.864 0.00 46 0.890 P16615 P602L Disease 0.660 0.886 0.00 31 0.787 P16615 P975R Disease NA 0.666 0.01 35 0.776 P16615 R131Q Disease 0.361 0.921 0.00 61 0.903 P16615 S186P Disease 0.690 0.172 0.54 -50 0.171 P16615 S495F Disease 0.798 0.704 0.00 45 0.884 P16615 S765L Disease 0.777 0.763 0.01 26 0.810 P16615 S920Y Disease NA 0.884 0.00 48 0.830 P16615 T357K Disease 0.996 0.880 0.00 68 0.942 P16615 V223M Disease 0.531 0.943 0.00 46 0.887 P16615 V843F Disease NA 0.845 0.10 -28 0.526 P16662 N378S Polymorphism 0.939 0.691 0.02 20 0.841 P16671 P90S Disease NA 0.944 0.00 46 0.886 P16671 F254L Disease 0.394 0.909 0.03 49 0.836 P16671 I413L Disease 0.202 0.494 1.00 5 0.320 P16671 S127L Polymorphism NA 0.970 0.00 16 0.849 P16671 V154F Polymorphism NA 0.754 0.05 22 0.575 P16860 M93L Polymorphism 0.115 0.083 0.22 4 0.032 P16860 R25L Polymorphism 0.439 0.221 0.06 24 0.128 P16860 R47H Polymorphism 0.536 0.034 0.01 20 0.114 P16871 E113D Polymorphism NA 0.053 0.42 5 0.064 P16871 I356V Polymorphism NA 0.097 0.50 1 0.052 P16871 T244I Polymorphism NA 0.217 0.54 -27 0.087 P16885 R268W Polymorphism 0.820 0.697 0.08 11 0.811 P16885 T541A Polymorphism 0.221 0.140 0.68 -13 0.187 P16930 F62C Disease 0.817 0.827 0.00 15 0.778 P16930 N16I Disease 0.864 0.952 0.00 58 0.940 P16930 Q64H Disease 0.502 0.467 0.02 17 0.484 P16930 A134D Disease 0.795 0.962 0.00 53 0.930 P16930 C193R Disease 0.468 0.895 0.04 54 0.885 P16930 D233V Disease 0.995 0.917 0.00 76 0.955 P16930 F405H Disease 0.738 0.934 0.00 72 0.943 P16930 G158D Disease 0.693 0.932 0.03 54 0.915 P16930 G207D Disease 0.657 0.910 0.06 65 0.923 P16930 G337S Disease 0.758 0.873 0.28 53 0.718 P16930 G369V Disease 0.560 0.914 0.00 55 0.893 P16930 P249T Disease 0.829 0.925 0.00 49 0.922 P16930 P261L Disease 0.678 0.850 0.00 54 0.898 P16930 P342L Disease 0.593 0.716 0.11 36 0.816 P16930 R341W Disease 0.914 0.836 0.03 43 0.888 P16930 R381G Disease 0.672 0.932 0.00 58 0.925 P16930 T294P Disease 0.355 0.789 0.05 8 0.748 P16930 V166G Disease 0.823 0.888 0.01 55 0.925 P16930 W234G Disease 0.849 0.937 0.03 62 0.942 P17019 R130Q Polymorphism 0.470 0.231 1.00 -35 0.272 P17020 E105K Polymorphism 0.260 0.229 0.76 29 0.342 P17021 T148K Polymorphism 0.447 0.371 0.91 -13 0.181 P17022 M240I Polymorphism 0.111 0.873 0.20 18 0.383 P17022 Q210R Polymorphism 0.123 0.201 0.54 34 0.225 P17023 Q218H Polymorphism 0.076 0.285 0.07 22 0.303 P17023 R224Q Polymorphism 0.097 0.266 0.02 37 0.285 P17027 S28G Polymorphism 0.346 0.169 0.07 -9 0.256 P17028 G331W Polymorphism 0.879 0.352 0.00 49 0.726 P17030 N453K Polymorphism NA 0.339 0.01 3 0.487 P17036 I102T Polymorphism 0.211 0.169 0.42 -15 0.220 P17040 D248N Polymorphism NA 0.051 1.00 27 0.070 P17040 Y432D Polymorphism NA 0.079 0.44 7 0.023 P17050 E325K Disease 0.454 0.940 0.02 42 0.801 P17050 R329Q Disease 0.563 0.780 0.35 31 0.722 P17050 R329W Disease 0.940 0.892 0.03 57 0.929 P17050 S160C Disease 0.525 0.650 0.28 0 0.470 P17066 A150T Polymorphism 0.682 0.931 0.00 48 0.828 P17066 D154N Polymorphism 0.638 0.886 0.00 15 0.794 P17066 D562E Polymorphism NA 0.190 0.22 -35 0.260 P17066 K528E Polymorphism 0.238 0.411 0.07 -24 0.336 P17066 K528R Polymorphism 0.211 0.232 0.07 -43 0.297 P17066 M572V Polymorphism NA 0.102 0.25 -44 0.174 P17066 N170K Polymorphism 0.334 0.889 0.05 -1 0.616 P17066 P178A Polymorphism 0.713 0.807 0.00 51 0.818 P17066 R260H Polymorphism 0.638 0.794 0.10 17 0.827 P17066 R577Q Polymorphism NA 0.082 0.44 -59 0.117 P17066 T626A Polymorphism NA 0.047 1.00 -34 0.031 P17097 G188R Polymorphism 0.625 0.551 0.55 26 0.486 P17097 S347L Polymorphism 0.826 0.520 0.02 38 0.866 P17181 T359M Polymorphism 0.109 0.115 0.19 -7 0.170 P17181 V168L Polymorphism 0.223 0.094 0.85 17 0.092 P17181 V307I Polymorphism 0.391 0.420 0.00 8 0.325 P17213 A12T Polymorphism NA 0.054 NA -61 0.017 P17213 A16V Polymorphism NA 0.065 0.05 -22 0.084 P17213 R90C Polymorphism 0.607 0.185 0.06 34 0.476 P17213 A196V Polymorphism 0.206 0.064 0.28 7 0.135 P17213 A280V Polymorphism 0.360 0.103 0.27 13 0.251 P17213 N404D Polymorphism 0.158 0.297 0.64 -10 0.198 P17252 M489V Polymorphism 0.158 0.413 0.59 16 0.242 P17275 L230V Polymorphism 0.179 0.122 0.29 5 0.197 P17301 N691K Polymorphism 0.359 0.551 0.69 -7 0.387 P17301 N927S Polymorphism 0.061 0.120 0.87 -35 0.065 P17301 K1127Q Polymorphism 0.432 0.172 0.45 -5 0.220 P17302 G2V Disease 0.589 0.933 0.00 19 0.857 P17302 L7V Disease 0.299 0.893 0.01 49 0.651 P17302 A40V Disease 0.366 0.884 0.02 17 0.595 P17302 G21R Disease 0.350 0.888 0.01 32 0.725 P17302 G22E Disease 0.565 0.972 0.00 69 0.930 P17302 H95R Disease 0.468 0.918 0.01 52 0.898 P17302 I31M Disease 0.407 0.895 0.01 29 0.725 P17302 K23T Disease 0.437 0.924 0.01 48 0.875 P17302 L11P Disease 0.743 0.979 0.00 54 0.934 P17302 L90V Disease 0.304 0.915 0.13 -4 0.456 P17302 P59H Disease 0.998 0.908 0.00 56 0.955 P17302 Q49K Disease 0.261 0.951 0.01 34 0.599 P17302 Q49P Disease 0.560 0.977 0.01 32 0.872 P17302 R76S Disease 0.491 0.918 0.08 54 0.828 P17302 S18P Disease 0.993 0.970 0.13 61 0.955 P17302 S27P Disease 0.442 0.954 0.01 17 0.618 P17302 S69Y Disease 0.625 0.807 0.03 -41 0.464 P17302 V96A Disease 0.311 0.719 1.00 -20 0.411 P17302 V96E Disease 0.570 0.921 0.02 55 0.900 P17302 V96M Disease 0.451 0.897 0.02 25 0.841 P17302 Y17S Disease 0.531 0.717 0.03 33 0.831 P17302 Y98C Disease 0.801 0.900 0.01 33 0.882 P17302 E110D Disease 0.319 0.229 0.06 8 0.353 P17302 G138R Disease 0.715 0.453 0.35 -17 0.570 P17302 G143S Disease 0.455 0.744 0.06 24 0.573 P17302 H194P Disease 0.657 0.926 0.01 44 0.884 P17302 I130T Disease 0.432 0.223 0.53 2 0.256 P17302 K102N Disease 0.438 0.510 0.12 -8 0.501 P17302 K134E Disease 0.347 0.483 0.42 -35 0.363 P17302 K134N Disease 0.431 0.616 0.20 1 0.485 P17302 L106P Disease 0.768 0.535 0.17 13 0.620 P17302 L113P Disease 0.768 0.533 0.21 25 0.601 P17302 M147T Disease 0.472 0.521 0.01 14 0.589 P17302 P283L Polymorphism 0.636 0.588 0.09 17 0.649 P17302 R148Q Polymorphism 0.221 0.689 0.36 25 0.455 P17302 R202C Polymorphism 0.836 0.943 0.00 58 0.947 P17302 R202H Disease 0.659 0.893 0.00 50 0.851 P17302 R239W Polymorphism 0.809 0.783 0.04 19 0.813 P17302 R362Q Disease 0.415 0.327 0.17 8 0.430 P17302 R376Q Disease 0.415 0.457 0.00 9 0.571 P17302 S201F Disease 0.701 0.945 0.00 57 0.927 P17302 S220Y Disease 0.719 0.891 0.00 37 0.878 P17302 S373G Polymorphism 0.349 0.150 0.38 -17 0.120 P17302 T154A Disease 0.291 0.800 0.03 31 0.552 P17302 T154N Disease 0.525 0.902 0.00 44 0.813 P17302 V216L Disease 0.272 0.838 0.02 32 0.601 P17405 V36A Polymorphism 0.078 0.113 0.09 -77 0.017 P17405 E246Q Disease 0.399 0.507 0.36 -1 0.444 P17405 F463S Disease 0.866 0.915 0.00 52 0.934 P17405 G242R Disease 0.983 0.942 0.00 55 0.951 P17405 G577S Disease 0.140 0.376 0.87 -22 0.230 P17405 H319Y Disease 0.919 0.904 0.00 68 0.935 P17405 H421Y Disease 0.409 0.702 1.00 25 0.478 P17405 L302P Disease 0.692 0.844 0.05 43 0.838 P17405 M382I Disease 0.425 0.406 0.05 51 0.672 P17405 N383S Disease 0.436 0.610 0.17 37 0.792 P17405 N389T Disease 0.892 0.793 0.00 63 0.929 P17405 P371S Disease 0.581 0.523 0.06 14 0.545 P17405 P475L Disease 0.828 0.700 0.00 40 0.841 P17405 R496L Disease 0.732 0.981 0.00 39 0.884 P17405 S248R Disease 0.223 0.648 0.33 7 0.323 P17405 S436R Disease 0.610 0.896 0.07 32 0.759 P17405 W391G Disease 0.930 0.684 0.13 44 0.904 P17405 Y446C Disease 0.934 0.890 0.01 65 0.938 P17405 Y537H Disease 0.953 0.963 0.00 76 0.952 P17516 C170Y Polymorphism 0.291 0.610 1.00 23 0.523 P17516 G135E Polymorphism NA 0.788 0.01 16 0.568 P17516 L311V Polymorphism NA 0.208 0.41 6 0.203 P17535 G20V Polymorphism 0.149 0.187 0.12 29 0.149 P17538 T250A Polymorphism 0.322 0.190 0.06 1 0.267 P17568 R106G Polymorphism 0.296 0.264 0.02 42 0.340 P17612 L41V Polymorphism 0.328 0.568 0.27 -6 0.456 P17612 R46Q Polymorphism 0.322 0.267 0.14 -7 0.350 P17612 S264C Polymorphism 0.681 0.090 0.19 -39 0.326 P17643 R326H Polymorphism 0.714 0.582 0.02 39 0.752 P17643 R356Q Disease 0.919 0.936 0.01 65 0.949 P17655 S68G Polymorphism NA 0.403 0.21 -10 0.317 P17655 E521Q Polymorphism 0.270 0.280 0.32 -14 0.308 P17655 K677Q Polymorphism 0.210 0.270 0.53 -31 0.295 P17661 S2I Disease NA 0.166 0.00 19 0.181 P17661 S46F Disease 0.456 0.490 0.07 45 0.481 P17661 S46Y Disease 0.436 0.514 0.07 27 0.520 P17661 A213V Disease 0.398 0.687 0.01 -15 0.449 P17661 A337P Disease 0.479 0.881 0.01 28 0.834 P17661 A357P Disease 0.437 0.808 0.17 3 0.750 P17661 A360P Disease 0.607 0.887 0.09 31 0.874 P17661 E245D Disease 0.325 0.739 0.00 14 0.568 P17661 I451M Disease 0.478 0.635 0.01 16 0.528 P17661 K449M Disease 0.741 0.658 0.00 33 0.808 P17661 K449T Disease 0.520 0.695 0.04 17 0.559 P17661 L345P Disease 0.775 0.932 0.00 54 0.917 P17661 L370P Disease 0.977 0.929 0.00 52 0.936 P17661 L385P Disease 0.980 0.918 0.00 38 0.903 P17661 N342D Disease 0.883 0.569 0.03 28 0.771 P17661 N393I Disease 0.986 0.748 0.00 13 0.872 P17661 Q389P Disease 0.908 0.930 0.00 43 0.876 P17661 R350P Disease 0.522 0.880 0.02 28 0.864 P17661 R355P Disease 0.592 0.947 0.01 56 0.906 P17661 R406W Disease 0.992 0.953 0.00 44 0.912 P17661 R454W Disease 0.958 0.873 0.00 38 0.886 P17661 S460I Disease 0.528 0.800 0.05 26 0.835 P17661 T442I Disease 0.442 0.365 0.47 -11 0.304 P17677 K162E Polymorphism 0.586 0.173 0.26 15 0.191 P17735 G362V Disease 0.688 0.878 0.00 40 0.858 P17787 Q397H Polymorphism 0.133 0.159 0.08 7 0.139 P17787 V287L Disease 0.371 0.255 0.12 -18 0.189 P17787 V287M Disease 0.653 0.210 0.00 -32 0.396 P17812 S571I Polymorphism 0.390 0.208 0.01 -13 0.278 P17813 L8P Disease NA 0.380 0.07 27 0.137 P17813 C53R Disease NA 0.715 0.00 68 0.876 P17813 G52V Disease NA 0.500 0.00 60 0.754 P17813 V49F Disease NA 0.500 0.00 66 0.819 P17813 A160D Disease 0.553 0.293 0.05 52 0.446 P17813 C412S Disease 0.610 0.686 0.00 50 0.841 P17813 D366H Polymorphism 0.540 0.100 0.02 52 0.211 P17813 G413V Disease 0.782 0.586 0.00 67 0.919 P17813 I263T Disease 0.463 0.619 0.00 34 0.703 P17813 L107R Disease 0.472 0.834 0.03 46 0.800 P17813 L221P Disease 0.759 0.681 0.01 37 0.734 P17813 L306P Disease 0.576 0.702 0.12 24 0.779 P17813 S615L Disease 0.648 0.614 0.00 40 0.622 P17813 V504M Disease 0.425 0.118 0.49 46 0.060 P17813 W149C Disease 0.615 0.724 0.00 53 0.867 P17844 S480A Polymorphism 0.033 0.111 1.00 -77 0.124 P17858 D237V Polymorphism 0.452 0.548 0.39 -21 0.456 P17900 A19T Polymorphism NA 0.119 NA -58 0.097 P17900 I59V Polymorphism NA 0.081 NA -33 0.017 P17900 M69V Polymorphism NA 0.057 NA -7 0.024 P17900 C138R Disease NA 0.961 NA 72 0.944 P17900 R169P Disease NA 0.746 NA 31 0.747 P17927 H1850D Polymorphism NA 0.420 0.63 48 0.263 P17927 I1615V Polymorphism NA 0.351 1.00 22 0.285 P17927 P1827R Polymorphism NA 0.266 0.52 46 0.304 P17927 R1601G Polymorphism NA 0.249 0.33 49 0.349 P17927 T1408M Polymorphism NA 0.468 0.22 43 0.459 P17931 P64H Polymorphism NA 0.266 0.19 52 0.471 P17931 T98P Polymorphism NA 0.119 0.50 -24 0.101 P17931 R183K Polymorphism 0.072 0.105 0.95 -42 0.072 P17936 A32G Polymorphism 0.142 0.080 0.43 -36 0.068 P17948 K60T Polymorphism NA 0.176 0.25 18 0.147 P17948 E144K Polymorphism 0.060 0.148 0.51 -16 0.116 P17948 E982A Polymorphism NA 0.264 0.49 2 0.329 P17948 I128L Polymorphism 0.115 0.597 0.04 -42 0.388 P17948 M938V Polymorphism NA 0.214 0.59 22 0.206 P17948 R281Q Polymorphism NA 0.361 0.46 19 0.347 P18054 R430H Polymorphism 0.343 0.542 0.11 -11 0.447 P18074 G47R Disease 0.892 0.968 0.00 69 0.950 P18074 T76A Disease 0.360 0.814 0.00 62 0.893 P18074 A594P Disease 0.830 0.972 0.00 38 0.891 P18074 A725P Disease 0.622 0.919 0.17 41 0.646 P18074 C259Y Disease 0.584 0.736 0.01 42 0.711 P18074 C663R Disease 0.793 0.949 0.01 61 0.939 P18074 D234N Disease 0.746 0.953 0.00 64 0.951 P18074 D312N Polymorphism 0.122 0.356 0.89 -1 0.221 P18074 D673G Disease 0.779 0.973 0.00 59 0.937 P18074 D681N Disease 0.737 0.966 0.00 63 0.950 P18074 G602D Disease 0.887 0.955 0.00 69 0.949 P18074 G713R Disease 0.503 0.782 0.02 40 0.817 P18074 H201Y Polymorphism 0.350 0.782 1.00 7 0.444 P18074 I199M Polymorphism 0.307 0.625 0.28 -10 0.404 P18074 K751Q Polymorphism 0.123 0.250 0.27 -12 0.186 P18074 L461V Disease 0.388 0.806 0.03 -1 0.712 P18074 L485P Disease 0.881 0.891 0.02 21 0.855 P18074 R112H Disease 0.740 0.965 0.00 61 0.937 P18074 R487G Disease 0.741 0.746 0.04 44 0.830 P18074 R511Q Disease 0.516 0.906 0.12 63 0.777 P18074 R592P Disease 0.714 0.907 0.27 32 0.849 P18074 R601L Disease 0.656 0.912 0.00 47 0.885 P18074 R601W Disease 0.299 0.970 0.00 53 0.877 P18074 R616C Polymorphism 0.922 0.958 0.00 60 0.948 P18074 R616P Disease 0.805 0.975 0.00 59 0.942 P18074 R616W Disease 0.929 0.976 0.00 59 0.948 P18074 R658C Disease 0.944 0.940 0.00 47 0.930 P18074 R658G Disease 0.830 0.917 0.00 41 0.900 P18074 R658H Disease 0.870 0.929 0.00 22 0.892 P18074 R666W Disease 0.959 0.973 0.00 67 0.957 P18074 R683Q Disease 0.771 0.936 0.00 70 0.952 P18074 R683W Disease 0.959 0.972 0.00 71 0.956 P18074 R722W Disease 0.815 0.939 0.00 36 0.892 P18074 S541R Disease 0.834 0.974 0.00 72 0.946 P18074 Y542C Disease 0.942 0.969 0.00 66 0.949 P18077 V33I Disease 0.348 0.693 0.12 16 0.550 P18084 L428V Polymorphism 0.195 0.122 1.00 -50 0.100 P18084 R431Q Polymorphism 0.683 0.335 0.44 -4 0.509 P18089 G211A Polymorphism 0.150 0.147 0.57 -9 0.117 P18146 T28I Polymorphism 0.198 0.190 0.00 21 0.276 P18146 S145R Polymorphism 0.479 0.222 0.05 45 0.408 P18206 L277M Disease NA 0.049 0.59 -31 0.054 P18206 R975W Disease 0.558 0.239 0.02 5 0.556 P18206 V234L Polymorphism NA 0.094 0.28 -39 0.102 P18428 E147K Polymorphism 0.258 0.340 0.16 48 0.469 P18428 F436L Polymorphism 0.222 0.242 0.51 -27 0.137 P18428 M242I Polymorphism 0.092 0.092 0.40 2 0.146 P18428 V166M Polymorphism 0.380 0.142 0.29 62 0.233 P18433 P109L Polymorphism NA 0.139 0.12 16 0.092 P18440 D251V Polymorphism 0.795 0.532 0.02 10 0.655 P18440 E261K Polymorphism 0.268 0.225 0.21 21 0.327 P18440 I263V Polymorphism 0.179 0.079 1.00 -36 0.079 P18440 M205V Polymorphism 0.203 0.412 0.69 39 0.332 P18440 R117T Polymorphism 0.174 0.335 0.32 10 0.199 P18440 R187Q Polymorphism 0.160 0.187 0.72 -1 0.165 P18462 Y33F Polymorphism 0.448 0.790 0.50 15 0.632 P18462 N151K Polymorphism 0.576 0.952 0.03 42 0.767 P18463 V36M Polymorphism 0.403 0.618 0.24 14 0.491 P18463 T104N Polymorphism 0.311 0.435 0.33 -12 0.352 P18465 H137Y Polymorphism 0.504 0.176 1.00 0 0.107 P18465 S140Y Polymorphism 0.439 0.478 1.00 -16 0.347 P18505 H421Q Polymorphism 0.127 0.516 0.43 10 0.105 P18505 I429N Polymorphism 0.327 0.601 0.13 -2 0.447 P18507 R82Q Disease 0.923 0.821 0.00 61 0.921 P18507 K328M Disease 0.670 0.832 0.00 28 0.881 P18507 R177G Disease 0.533 0.481 0.09 11 0.559 P18509 D54G Polymorphism 0.088 0.399 0.29 -3 0.405 P18545 P27H Polymorphism 0.763 0.428 NA 45 0.628 P18564 P437T Polymorphism 0.866 0.905 0.01 16 0.880 P18577 L60I Polymorphism NA 0.171 0.40 -40 0.137 P18577 N68S Polymorphism 0.212 0.394 0.41 1 0.159 P18577 H323P Polymorphism 0.085 0.952 0.19 51 0.291 P18577 H329R Polymorphism 0.142 0.897 0.10 73 0.824 P18577 I325S Polymorphism 0.092 0.539 0.46 -17 0.082 P18577 I331N Polymorphism 0.068 0.379 0.17 22 0.171 P18577 L245V Polymorphism 0.118 0.776 0.16 9 0.298 P18577 P103S Polymorphism 0.146 0.075 0.61 -12 0.142 P18577 P226A Polymorphism 0.362 0.090 1.00 -23 0.075 P18577 R263G Polymorphism 0.218 0.188 1.00 19 0.158 P18577 T182S Polymorphism 0.087 0.276 0.47 -37 0.199 P18577 V398E Polymorphism 0.062 0.491 0.46 -23 0.096 P18583 R1575C Polymorphism 0.454 0.101 0.05 -9 0.011 P18827 L136Q Polymorphism NA 0.124 0.61 -26 0.047 P18846 P191A Polymorphism 0.490 0.436 0.08 11 0.338 P18847 T38M Polymorphism 0.634 0.284 0.02 38 0.425 P18848 P258A Polymorphism 0.220 0.161 0.12 25 0.216 P18858 A24V Polymorphism NA 0.140 1.00 8 0.106 P18858 P52L Polymorphism NA 0.295 0.01 13 0.246 P18858 G249E Polymorphism NA 0.156 0.98 -4 0.206 P18858 M480V Polymorphism NA 0.211 1.00 -40 0.165 P18858 N267S Polymorphism NA 0.109 0.38 -7 0.178 P18858 R409H Polymorphism 0.474 0.671 0.22 -1 0.479 P18858 T614I Polymorphism 0.506 0.620 0.16 3 0.601 P18887 R7L Polymorphism NA 0.186 0.00 23 0.374 P18887 V72A Polymorphism NA 0.744 0.00 36 0.611 P18887 E157K Polymorphism NA 0.058 0.00 -3 0.119 P18887 K298N Polymorphism NA 0.229 0.03 -2 0.251 P18887 P161L Polymorphism NA 0.170 0.00 -9 0.269 P18887 P309S Polymorphism 0.555 0.267 0.39 -25 0.394 P18887 R280H Polymorphism NA 0.352 0.02 26 0.252 P18887 R399Q Polymorphism 0.374 0.219 0.35 32 0.375 P18887 R559Q Polymorphism 0.446 0.495 0.16 46 0.730 P18887 S485Y Polymorphism 0.705 0.206 0.02 13 0.217 P18887 T304A Polymorphism 0.232 0.194 0.33 3 0.207 P19012 T147A Polymorphism 0.094 0.092 0.70 -39 0.113 P19013 E449K Disease 0.876 0.941 0.00 50 0.892 P19021 V49L Polymorphism NA 0.103 0.12 11 0.180 P19022 A21T Polymorphism 0.098 0.100 0.37 -26 0.060 P19022 A118T Polymorphism NA 0.169 0.63 -60 0.120 P19022 I212L Polymorphism 0.253 0.624 0.02 24 0.478 P19022 N845S Polymorphism 0.186 0.275 0.75 -3 0.253 P19022 S196T Polymorphism 0.748 0.467 0.03 16 0.657 P19022 T454A Polymorphism 0.123 0.262 0.78 2 0.223 P19075 G73A Polymorphism NA 0.888 0.00 57 0.869 P19087 G183D Polymorphism 0.923 0.901 0.00 66 0.934 P19087 L107I Polymorphism 0.330 0.601 0.82 -63 0.368 P19087 V124M Polymorphism 0.418 0.634 0.05 -48 0.460 P19099 A29T Polymorphism 0.106 0.105 0.66 -27 0.105 P19099 E198D Disease 0.977 0.681 0.00 54 0.963 P19099 E383V Polymorphism 0.564 0.100 0.01 3 0.304 P19099 G435S Polymorphism 0.089 0.367 0.73 -43 0.235 P19099 L461P Disease 0.794 0.882 0.05 8 0.866 P19099 N222T Polymorphism 0.121 0.255 0.29 -13 0.170 P19099 N281S Polymorphism NA 0.191 0.21 -20 0.258 P19099 R181W Disease 0.817 0.601 0.03 37 0.757 P19099 T185I Disease 0.550 0.156 0.01 -12 0.397 P19099 T498A Disease NA 0.240 0.04 3 0.286 P19099 V386A Disease 0.217 0.094 0.26 -10 0.187 P19099 V403E Polymorphism 0.917 0.879 0.00 57 0.930 P19113 T31M Polymorphism NA 0.069 0.22 -39 0.120 P19113 E644D Polymorphism NA 0.384 0.00 34 0.159 P19113 F553L Polymorphism 0.107 0.275 0.00 45 0.296 P19174 T209N Polymorphism 0.061 0.603 0.85 16 0.095 P19224 A510P Polymorphism NA 0.442 0.21 14 0.565 P19224 R184S Polymorphism 0.713 0.293 0.10 17 0.514 P19235 N487S Disease 0.130 0.105 0.14 28 0.110 P19235 P380A Polymorphism 0.378 0.121 0.70 23 0.091 P19235 P488S Disease 0.417 0.063 0.00 18 0.103 P19237 R67W Polymorphism 0.771 0.656 0.00 25 0.786 P19256 S15G Polymorphism 0.310 0.061 NA -69 0.015 P19320 M18I Polymorphism NA 0.222 0.49 7 0.082 P19320 S318F Polymorphism NA 0.164 0.06 12 0.270 P19320 T384A Polymorphism 0.081 0.148 0.67 22 0.183 P19320 V421I Polymorphism 0.237 0.173 0.57 37 0.187 P19338 P68L Polymorphism NA 0.143 0.11 -4 0.152 P19338 P122L Polymorphism NA 0.167 0.00 7 0.243 P19367 L529S Disease 0.850 0.804 0.01 37 0.863 P19367 T680S Disease 0.502 0.840 0.00 58 0.867 P19429 A2V Disease 0.081 0.091 0.02 -44 0.103 P19429 P82S Disease 0.609 0.516 0.13 -11 0.485 P19429 R79C Polymorphism 0.636 0.650 0.01 52 0.836 P19429 A157V Disease 0.492 0.707 0.02 9 0.557 P19429 A171T Disease 0.749 0.594 0.21 -14 0.711 P19429 D190H Disease 0.965 0.772 0.01 36 0.907 P19429 D196N Disease 0.505 0.366 0.01 17 0.593 P19429 K178E Disease 0.801 0.854 0.13 -1 0.830 P19429 K206Q Disease 0.790 0.669 0.00 45 0.831 P19429 L144Q Disease 0.973 0.940 0.00 47 0.945 P19429 R141Q Disease 0.300 0.355 0.03 41 0.538 P19429 R145G Disease 0.788 0.698 0.01 28 0.831 P19429 R145W Disease 0.947 0.644 0.00 30 0.805 P19429 R162P Disease 0.545 0.696 0.01 29 0.791 P19429 R162Q Disease 0.256 0.109 0.02 7 0.203 P19429 R186Q Disease 0.541 0.176 0.52 -26 0.337 P19429 R192H Disease 0.910 0.847 0.02 42 0.891 P19429 R204H Disease 0.910 0.740 0.00 55 0.923 P19429 S166F Disease 0.633 0.542 0.04 30 0.744 P19438 C59R Disease 0.954 0.841 0.04 75 0.946 P19438 C59S Disease 0.890 0.730 0.01 59 0.927 P19438 C62G Disease 0.996 0.788 0.00 70 0.958 P19438 C62Y Disease 0.999 0.863 0.00 74 0.965 P19438 C81F Disease 0.998 0.569 0.00 68 0.957 P19438 C99S Disease 0.536 0.735 0.01 59 0.825 P19438 H51Q Disease 0.831 0.353 0.06 29 0.477 P19438 P75L Disease 0.693 0.342 0.37 41 0.544 P19438 T79M Disease 0.792 0.152 0.02 42 0.399 P19438 C117R Disease 0.954 0.900 0.01 78 0.948 P19438 C117Y Disease 0.967 0.878 0.01 71 0.960 P19438 R121P Disease 0.583 0.706 0.24 51 0.843 P19438 R121Q Disease 0.166 0.138 0.77 14 0.116 P19438 S115G Disease 0.519 0.137 0.40 34 0.275 P19440 N419D Polymorphism 0.396 0.820 0.56 40 0.560 P19440 V272A Polymorphism 0.342 0.129 0.52 1 0.160 P19447 F99S Disease 0.784 0.936 0.00 46 0.881 P19447 G402C Polymorphism 0.764 0.345 0.02 30 0.605 P19447 K117R Polymorphism 0.176 0.236 0.31 -34 0.186 P19447 S704L Polymorphism 0.298 0.323 0.18 9 0.453 P19447 S735P Polymorphism 0.391 0.231 0.21 25 0.324 P19447 T119P Disease 0.791 0.957 0.00 65 0.942 P19474 G96R Polymorphism 0.124 0.277 0.17 26 0.258 P19474 P52A Polymorphism 0.965 0.636 0.04 45 0.905 P19474 E231K Polymorphism NA 0.331 0.27 11 0.349 P19525 I506V Polymorphism 0.114 0.051 0.51 -5 0.090 P19525 V428E Polymorphism 0.725 0.872 0.00 57 0.897 P19526 A12V Polymorphism 0.055 0.197 0.02 7 0.204 P19526 D148Y Polymorphism 0.701 0.717 0.00 53 0.845 P19532 S96C Polymorphism NA 0.198 0.01 15 0.187 P19544 C330Y Disease 0.789 0.837 0.00 69 0.941 P19544 C355G Disease 0.971 0.805 0.00 70 0.985 P19544 C355Y Disease 0.993 0.841 0.00 74 0.990 P19544 C360G Disease 0.972 0.763 0.00 73 0.983 P19544 C360Y Disease 0.993 0.792 0.00 76 0.990 P19544 C385R Disease 0.989 0.795 0.00 82 0.955 P19544 C388F Disease 0.991 0.818 0.00 81 0.962 P19544 C388Y Disease 0.993 0.822 0.00 82 0.957 P19544 D396G Disease 0.966 0.500 0.01 30 0.819 P19544 D396N Disease 0.965 0.527 0.02 53 0.972 P19544 D396Y Disease 0.991 0.495 0.06 59 0.949 P19544 F383L Disease 0.946 0.490 0.00 44 0.782 P19544 F392L Disease 0.946 0.670 0.01 69 0.949 P19544 G253A Disease NA 0.136 0.22 -20 0.113 P19544 H373Q Disease 0.988 0.805 0.00 73 0.992 P19544 H373Y Disease 0.978 0.789 0.00 72 0.990 P19544 H377R Disease 0.983 0.791 0.00 76 0.990 P19544 H377Y Disease 0.978 0.785 0.00 74 0.990 P19544 H401Y Disease 0.978 0.740 0.00 74 0.988 P19544 H405R Disease 0.983 0.768 0.00 78 0.991 P19544 L398P Disease 0.986 0.658 0.00 77 0.975 P19544 M342R Disease 0.586 0.270 0.69 25 0.067 P19544 P181S Disease 0.133 0.123 0.14 2 0.105 P19544 Q369P Disease 0.534 0.480 0.10 56 0.695 P19544 R312Q Disease 0.287 0.418 0.57 2 0.317 P19544 R366C Disease 0.992 0.664 0.11 54 0.964 P19544 R366H Disease 0.985 0.544 0.30 34 0.898 P19544 R366L Disease 0.982 0.660 0.23 46 0.934 P19544 R394L Disease 0.982 0.713 0.17 52 0.963 P19544 R394P Disease 0.984 0.805 0.02 50 0.978 P19544 R394Q Disease 0.973 0.703 0.70 26 0.852 P19544 R394W Disease 0.994 0.737 0.07 59 0.972 P19544 S223N Disease 0.027 0.330 0.01 32 0.409 P19622 L121F Polymorphism NA 0.238 0.73 -10 0.131 P19623 L149V Polymorphism 0.239 0.671 1.00 -51 0.326 P19634 N682K Polymorphism 0.331 0.383 0.94 0 0.228 P19652 R38Q Polymorphism 0.154 0.079 0.38 -18 0.055 P19652 V99A Polymorphism 0.349 0.290 0.11 30 0.378 P19652 C167R Polymorphism 0.124 0.351 0.17 16 0.049 P19784 E188A Polymorphism 0.446 0.216 0.73 3 0.319 P19793 A327S Polymorphism 0.312 0.459 0.65 -1 0.287 P19793 S336I Polymorphism 0.660 0.863 0.08 36 0.858 P19823 L569V Polymorphism 0.682 0.291 0.11 -14 0.584 P19823 N263S Polymorphism NA 0.328 0.69 -7 0.249 P19827 D844E Polymorphism 0.304 0.288 0.16 -57 0.284 P19827 S263T Polymorphism NA 0.290 0.02 6 0.248 P19838 H711Q Polymorphism NA 0.320 0.31 -1 0.289 P19838 M506V Polymorphism 0.130 0.207 0.44 30 0.091 P19838 T489I Polymorphism 0.089 0.081 0.26 -15 0.081 P19838 T566I Polymorphism NA 0.697 0.41 -34 0.212 P19876 H3R Polymorphism 0.117 0.036 1.00 -74 0.009 P19878 G78E Disease 0.781 0.956 0.00 70 0.941 P19878 R77Q Disease 0.355 0.421 0.00 73 0.381 P19878 A128V Disease 0.765 0.480 0.01 44 0.700 P19878 H389Q Polymorphism 0.215 0.190 0.65 42 0.236 P19878 K181R Polymorphism 0.124 0.095 0.97 -26 0.079 P19878 R395W Polymorphism 0.826 0.322 0.02 45 0.599 P19878 V297A Polymorphism 0.302 0.180 0.03 46 0.194 P19883 E152Q Polymorphism 0.909 0.056 0.48 -19 0.141 P19957 T17M Polymorphism 0.606 0.466 0.04 -47 0.395 P19957 T34P Polymorphism 0.418 0.318 0.40 -56 0.211 P19971 R44Q Disease 0.425 0.839 0.11 40 0.789 P19971 E289A Disease 0.831 0.821 0.03 35 0.851 P19971 G145R Disease 0.847 0.889 0.00 67 0.936 P19971 G153S Disease 0.867 0.821 0.00 61 0.933 P19971 K222R Disease 0.643 0.798 0.00 49 0.892 P20020 M267R Polymorphism 0.763 0.523 0.52 54 0.860 P20023 S639N Polymorphism 0.502 0.267 0.33 31 0.485 P20036 A42M Polymorphism 0.300 0.231 0.26 19 0.278 P20036 A42T Polymorphism 0.181 0.225 0.53 -19 0.184 P20036 A82T Polymorphism 0.196 0.255 0.39 -25 0.252 P20036 E59D Polymorphism 0.261 0.578 0.40 -15 0.325 P20036 M54T Polymorphism 0.693 0.400 0.61 7 0.578 P20036 P49T Polymorphism 0.403 0.720 0.08 -37 0.553 P20036 Q81R Polymorphism 0.174 0.511 0.38 -24 0.220 P20036 F191V Polymorphism 0.234 0.259 1.00 -5 0.160 P20036 K142R Polymorphism 0.249 0.311 0.03 34 0.240 P20036 L104A Polymorphism 0.453 0.406 0.18 36 0.423 P20036 L158P Polymorphism 0.220 0.658 0.23 0 0.313 P20036 N100D Polymorphism 0.561 0.586 0.21 36 0.540 P20039 F55Y Polymorphism 0.322 0.228 1.00 -4 0.278 P20039 G115V Polymorphism 0.232 0.457 0.32 -3 0.312 P20039 R100E Polymorphism 0.210 0.414 0.97 22 0.329 P20039 V236M Polymorphism 0.774 0.500 0.04 -35 0.764 P20061 R35H Polymorphism 0.312 0.206 0.42 -8 0.114 P20062 F89L Polymorphism 0.090 0.083 0.79 4 0.050 P20062 I23V Polymorphism 0.219 0.118 1.00 0 0.130 P20062 I219L Polymorphism 0.097 0.286 0.59 -26 0.152 P20062 M198T Polymorphism 0.517 0.785 0.04 52 0.848 P20062 R215W Polymorphism 0.635 0.107 0.18 28 0.251 P20062 R399Q Polymorphism 0.367 0.103 0.27 37 0.132 P20138 G304R Polymorphism NA 0.183 NA 12 0.183 P20138 I242L Polymorphism 0.532 0.404 0.10 20 0.558 P20138 R202W Polymorphism 0.897 0.779 0.01 63 0.920 P20151 R250W Polymorphism 0.650 0.710 0.19 39 0.748 P20273 A34T Polymorphism 0.274 0.623 0.15 44 0.506 P20273 E203K Polymorphism 0.070 0.658 0.96 18 0.087 P20273 G551R Polymorphism 0.221 0.382 0.45 42 0.363 P20273 R669C Polymorphism NA 0.848 0.04 54 0.824 P20309 V65I Polymorphism NA 0.099 0.54 -22 0.156 P20309 L431P Polymorphism NA 0.590 0.10 23 0.462 P20333 L264P Polymorphism NA 0.625 0.01 28 0.436 P20333 M196R Polymorphism 0.440 0.383 0.57 56 0.285 P20333 P301R Polymorphism NA 0.138 0.06 37 0.059 P20333 V187M Polymorphism 0.032 0.133 0.22 29 0.136 P20585 Y789F Polymorphism NA 0.475 0.00 -9 0.464 P20591 A381V Polymorphism 0.265 0.546 1.00 -8 0.282 P20591 V379I Polymorphism 0.244 0.177 1.00 -40 0.097 P20594 P32T Disease NA 0.514 0.02 22 0.587 P20594 A409T Disease NA 0.240 0.17 -13 0.299 P20594 D176E Disease NA 0.579 0.08 -3 0.463 P20594 G413E Disease NA 0.408 0.38 34 0.392 P20594 G959A Disease 0.998 0.832 0.00 59 0.943 P20594 M232I Polymorphism NA 0.219 0.19 -4 0.184 P20594 R776W Disease 0.963 0.950 0.00 72 0.951 P20594 R957C Disease 0.992 0.937 0.00 74 0.942 P20594 T297M Disease NA 0.672 0.00 29 0.643 P20594 V882I Polymorphism 0.396 0.298 0.10 8 0.378 P20594 W115G Disease NA 0.848 0.00 46 0.851 P20594 Y338C Disease NA 0.889 0.02 35 0.829 P20594 Y708C Disease 0.970 0.959 0.00 63 0.951 P20618 P11A Polymorphism NA 0.155 1.00 3 0.129 P20618 I208N Polymorphism 0.278 0.731 0.42 -8 0.327 P20700 A501V Polymorphism 0.383 0.392 0.15 5 0.427 P20702 A251T Polymorphism 0.233 0.601 0.89 -26 0.283 P20702 I564V Polymorphism 0.058 0.500 0.09 30 0.142 P20702 P517R Polymorphism 0.942 0.567 0.02 22 0.781 P20711 A91V Disease NA 0.790 0.01 22 0.820 P20711 E61D Polymorphism NA 0.214 0.13 -25 0.255 P20711 P47H Disease NA 0.654 0.00 35 0.794 P20711 A275T Disease 0.684 0.867 0.00 46 0.881 P20711 F309L Disease 0.429 0.783 1.00 24 0.489 P20711 G102S Disease NA 0.671 0.00 39 0.614 P20711 L408I Disease 0.440 0.398 0.02 17 0.390 P20711 M217V Polymorphism 0.364 0.919 0.08 22 0.566 P20711 R347Q Disease 0.356 0.387 0.19 50 0.608 P20711 R462Q Polymorphism 0.230 0.143 0.33 0 0.222 P20711 S147R Disease NA 0.901 0.00 68 0.912 P20711 S250F Disease 0.856 0.832 0.00 43 0.878 P20742 L379V Polymorphism NA 0.286 0.43 -50 0.252 P20742 V691M Polymorphism 0.198 0.125 0.22 -25 0.213 P20742 I1443N Polymorphism 0.445 0.616 0.07 34 0.514 P20794 F550L Polymorphism NA 0.509 0.03 35 0.485 P20794 I189V Polymorphism 0.163 0.347 0.16 19 0.263 P20794 N384S Polymorphism NA 0.064 0.32 23 0.088 P20794 P520S Polymorphism NA 0.111 1.00 -23 0.096 P20807 V4I Disease NA 0.128 0.23 -27 0.093 P20807 D77N Disease NA 0.903 0.00 64 0.921 P20807 P26L Disease NA 0.181 0.03 10 0.209 P20807 S86F Disease NA 0.747 0.00 63 0.881 P20807 A160G Polymorphism 0.379 0.577 0.01 24 0.632 P20807 A702V Disease 0.375 0.673 0.09 2 0.523 P20807 A798E Disease 0.482 0.520 1.00 -34 0.374 P20807 C137R Disease 0.670 0.698 0.03 22 0.863 P20807 D705G Disease 0.880 0.920 0.07 18 0.883 P20807 D705H Disease 0.944 0.903 0.00 22 0.893 P20807 E107K Polymorphism 0.305 0.696 0.68 -27 0.349 P20807 E217K Disease 0.364 0.939 0.02 48 0.805 P20807 E226K Disease 0.879 0.939 0.01 49 0.939 P20807 E622A Polymorphism NA 0.186 0.36 18 0.291 P20807 F731S Disease 0.551 0.859 0.00 29 0.855 P20807 G214S Disease 0.467 0.939 0.00 47 0.844 P20807 G222R Disease 0.671 0.971 0.00 68 0.939 P20807 G234E Disease 0.971 0.890 0.03 58 0.951 P20807 G441D Disease 0.947 0.847 0.04 50 0.930 P20807 G445R Disease 0.973 0.848 0.00 61 0.948 P20807 G496R Disease 0.671 0.830 0.00 41 0.798 P20807 G567W Disease 0.879 0.712 0.01 46 0.880 P20807 H334Q Disease 0.969 0.910 0.00 77 0.950 P20807 H774D Disease 0.231 0.429 0.98 24 0.193 P20807 I162L Disease 0.178 0.684 0.01 21 0.446 P20807 I502T Disease 0.898 0.818 0.00 30 0.877 P20807 L182Q Disease 0.598 0.845 0.00 45 0.874 P20807 L189P Disease 0.973 0.915 0.00 12 0.871 P20807 P183L Disease 0.990 0.814 0.00 42 0.922 P20807 P319L Disease NA 0.412 0.97 26 0.435 P20807 Q486E Disease 0.923 0.749 0.00 44 0.884 P20807 Q638P Disease 0.345 0.487 0.16 6 0.432 P20807 R118G Disease 0.536 0.782 0.02 37 0.738 P20807 R437C Disease 0.797 0.816 0.04 29 0.731 P20807 R440W Disease 0.848 0.800 0.00 35 0.863 P20807 R448C Disease 0.797 0.879 0.01 39 0.876 P20807 R448G Disease 0.535 0.791 0.04 45 0.789 P20807 R448H Disease 0.599 0.683 0.05 22 0.654 P20807 R489Q Disease 0.426 0.858 0.05 51 0.717 P20807 R489W Disease 0.848 0.849 0.05 58 0.860 P20807 R490Q Disease 0.426 0.894 0.00 30 0.764 P20807 R490W Disease 0.848 0.882 0.00 34 0.887 P20807 R493W Disease 0.848 0.859 0.00 50 0.926 P20807 R541Q Disease 0.927 0.939 0.00 61 0.948 P20807 R572Q Disease 0.933 0.913 0.00 60 0.946 P20807 R572W Disease 0.988 0.900 0.00 64 0.955 P20807 R698P Disease 0.632 0.949 0.01 49 0.922 P20807 R748Q Disease 0.890 0.821 0.02 28 0.849 P20807 R769Q Disease 0.937 0.874 0.00 51 0.946 P20807 S215P Disease 0.528 0.949 0.07 38 0.874 P20807 S479G Disease 0.300 0.669 0.01 14 0.582 P20807 S606L Disease NA 0.340 0.33 -2 0.238 P20807 S744G Disease 0.349 0.483 0.22 34 0.486 P20807 T184M Disease 0.628 0.448 0.01 -1 0.650 P20807 T232I Disease 0.955 0.885 0.00 50 0.944 P20807 V354G Disease 0.555 0.602 0.00 40 0.787 P20807 W360C Disease 0.986 0.915 0.00 69 0.960 P20807 Y336N Disease 0.973 0.938 0.00 65 0.956 P20810 A537V Polymorphism 0.573 0.355 0.38 21 0.398 P20810 C408S Polymorphism 0.137 0.137 0.55 -18 0.042 P20810 E380K Polymorphism 0.101 0.047 0.74 0 0.037 P20810 E592G Polymorphism 0.287 0.188 0.34 19 0.308 P20813 D28G Polymorphism 0.184 0.217 1.00 -3 0.025 P20813 Q21L Polymorphism 0.110 0.230 0.10 -21 0.153 P20813 R29P Polymorphism 0.265 0.507 0.01 51 0.757 P20813 T26S Polymorphism 0.084 0.138 0.82 -30 0.072 P20813 I328T Polymorphism 0.864 0.687 0.00 23 0.807 P20813 K262R Polymorphism 0.158 0.037 1.00 -50 0.035 P20813 N289K Polymorphism 0.123 0.208 0.07 -15 0.127 P20813 P167A Polymorphism 0.879 0.473 0.00 13 0.679 P20813 Q172H Polymorphism 0.163 0.235 0.53 -29 0.144 P20813 R140Q Polymorphism 0.275 0.554 0.16 2 0.373 P20813 S259R Polymorphism 0.487 0.500 0.05 8 0.556 P20815 H30Y Polymorphism 0.173 0.461 0.49 0 0.225 P20815 R28C Polymorphism 0.497 0.860 0.15 45 0.868 P20815 D277E Polymorphism 0.136 0.180 0.41 -56 0.146 P20815 I371V Polymorphism 0.128 0.037 0.54 -45 0.093 P20815 Q200R Polymorphism 0.265 0.629 0.16 0 0.357 P20815 T398N Polymorphism 0.316 0.481 0.02 37 0.481 P20823 E48K Disease 0.102 0.214 0.12 17 0.179 P20823 G20R Disease 0.891 0.689 0.00 63 0.931 P20823 G31D Disease 0.417 0.265 0.58 -24 0.203 P20823 I27L Polymorphism 0.198 0.259 0.20 -12 0.220 P20823 L12H Disease 0.917 0.524 0.00 56 0.916 P20823 A161T Disease 0.637 0.707 0.02 19 0.798 P20823 C241G Disease 0.785 0.872 0.02 56 0.920 P20823 E619K Disease NA 0.107 0.12 45 0.078 P20823 G415R Disease 0.770 0.277 0.01 40 0.572 P20823 G574S Polymorphism NA 0.045 0.90 20 0.034 P20823 H143Y Disease 0.770 0.616 0.01 52 0.695 P20823 H514R Polymorphism 0.227 0.371 0.22 36 0.466 P20823 I128N Disease 0.733 0.937 0.00 51 0.905 P20823 I618M Disease NA 0.213 0.00 39 0.197 P20823 K117E Disease 0.459 0.372 0.13 18 0.273 P20823 K158N Disease 0.747 0.901 0.01 46 0.833 P20823 K205Q Disease 0.675 0.490 0.05 35 0.624 P20823 L107R Disease 0.726 0.849 0.00 43 0.861 P20823 P129T Disease 0.844 0.589 0.04 34 0.707 P20823 P447L Disease 0.878 0.500 0.00 30 0.754 P20823 P519L Disease 0.474 0.428 0.00 29 0.519 P20823 R131Q Disease 0.736 0.616 0.02 50 0.825 P20823 R131W Disease 0.951 0.838 0.00 55 0.947 P20823 R159Q Disease 0.736 0.759 0.05 56 0.894 P20823 R159W Disease 0.951 0.916 0.00 55 0.958 P20823 R200W Disease 0.951 0.914 0.00 67 0.962 P20823 R203C Disease 0.934 0.860 0.00 73 0.942 P20823 R203H Disease 0.847 0.742 0.00 68 0.928 P20823 R229Q Disease 0.736 0.762 0.00 64 0.907 P20823 R263C Disease 0.934 0.954 0.00 64 0.953 P20823 R271W Disease 0.827 0.963 0.00 75 0.948 P20823 R272H Disease 0.569 0.897 0.01 69 0.924 P20823 R583G Disease NA 0.141 0.00 27 0.180 P20823 S142F Disease 0.870 0.808 0.00 53 0.916 P20823 S432C Disease 0.720 0.493 0.01 40 0.669 P20823 S487N Polymorphism 0.207 0.158 0.29 15 0.127 P20823 S594I Disease NA 0.230 0.00 45 0.246 P20823 T260M Disease 0.876 0.925 0.00 48 0.895 P20823 T537R Disease 0.541 0.401 0.00 45 0.606 P20823 T620I Disease NA 0.103 0.01 21 0.130 P20823 V133M Disease 0.750 0.534 0.01 52 0.843 P20823 V259D Disease 0.880 0.971 0.00 66 0.948 P20823 Y122C Disease 0.929 0.831 0.01 45 0.899 P20827 D159V Polymorphism 0.142 0.074 0.67 -21 0.074 P20839 D226N Disease 0.681 0.848 0.00 50 0.882 P20839 R224P Disease 0.715 0.903 0.02 19 0.874 P20839 V268I Disease 0.369 0.394 0.10 -16 0.410 P20849 E684K Polymorphism 0.119 0.270 NA 11 0.160 P20849 M767V Polymorphism 0.284 0.525 NA 9 0.197 P20851 K102Q Polymorphism 0.144 0.310 0.58 -29 0.155 P20851 P198S Polymorphism 0.140 0.381 0.87 22 0.287 P20853 C64R Polymorphism 0.468 0.744 0.61 -29 0.318 P20853 H274R Polymorphism 0.247 0.618 0.42 -20 0.291 P20853 M368T Polymorphism 0.560 0.298 0.24 3 0.528 P20908 L25P Disease 0.570 0.430 0.00 -71 0.585 P20908 L25R Disease 0.397 0.361 0.00 -57 0.555 P20908 G530S Disease NA 0.876 0.54 -6 0.647 P20908 C1639S Disease NA 0.843 0.00 -3 0.788 P20908 G1486C Disease 0.997 0.684 0.00 52 0.955 P20908 G1489D Disease 0.998 0.791 0.00 64 0.980 P20916 L202M Polymorphism 0.596 0.847 0.01 40 0.606 P20929 E191Q Polymorphism NA 0.523 0.21 0 0.487 P20929 T146A Polymorphism NA 0.211 0.29 0 0.237 P20929 I6546V Polymorphism NA 0.053 0.79 0 0.068 P20929 K1027N Polymorphism NA 0.352 0.68 0 0.273 P20929 P4271L Polymorphism NA 0.463 1.00 0 0.299 P20929 R4401T Polymorphism NA 0.108 0.72 0 0.093 P20929 V1491M Polymorphism 0.142 0.270 0.17 0 0.260 P20929 V2952G Polymorphism NA 0.619 0.25 0 0.490 P20929 W3360C Polymorphism NA 0.356 0.46 0 0.411 P20929 Y1301H Polymorphism 0.424 0.190 0.35 0 0.050 P20930 T725I Polymorphism NA 0.168 0.20 32 0.157 P20930 A2108V Polymorphism NA 0.082 0.03 19 0.118 P20930 D2781Y Polymorphism NA 0.156 0.04 42 0.270 P20930 D3584N Polymorphism 0.400 0.172 0.35 41 0.309 P20930 D3908N Polymorphism 0.439 0.094 0.02 41 0.149 P20930 G2545R Polymorphism NA 0.040 0.37 42 0.085 P20930 G3436A Polymorphism NA 0.293 0.11 36 0.245 P20930 G3827W Polymorphism 0.873 0.349 0.03 43 0.595 P20930 H1961Q Polymorphism NA 0.108 0.23 27 0.109 P20930 H3437Q Polymorphism NA 0.179 1.00 40 0.145 P20930 H3630Y Polymorphism 0.347 0.475 0.03 52 0.692 P20930 R1437C Polymorphism NA 0.354 0.00 43 0.590 P20930 R1699C Polymorphism NA 0.201 0.00 42 0.398 P20930 R2540Q Polymorphism NA 0.103 0.45 47 0.133 P20930 R3490C Polymorphism 0.525 0.165 0.03 52 0.390 P20930 R3564H Polymorphism 0.195 0.049 0.53 -6 0.033 P20930 R3814C Polymorphism 0.877 0.183 0.07 53 0.411 P20930 S1184L Polymorphism NA 0.310 0.10 16 0.414 P20930 S1750F Polymorphism NA 0.333 0.00 34 0.511 P20930 S3427Y Polymorphism NA 0.198 0.01 43 0.283 P20930 S3751Y Polymorphism 0.877 0.162 0.01 46 0.446 P20930 T3696A Polymorphism 0.244 0.104 0.19 29 0.111 P20930 V3179G Polymorphism NA 0.110 0.46 35 0.054 P20930 Y2119H Polymorphism NA 0.067 0.24 21 0.026 P20930 Y2194H Polymorphism NA 0.069 0.03 26 0.035 P20930 Y3105D Polymorphism NA 0.223 0.64 47 0.350 P20933 G60D Disease NA 0.859 0.01 48 0.878 P20933 S72P Disease 0.361 0.869 0.06 35 0.764 P20933 V12L Disease NA 0.079 0.89 -84 0.155 P20933 A101V Disease 0.710 0.896 0.01 45 0.882 P20933 C163S Disease 0.595 0.766 0.51 21 0.592 P20933 C306R Disease 0.356 0.908 0.04 29 0.780 P20933 F135S Disease 0.837 0.910 0.00 45 0.896 P20933 G100E Disease 0.865 0.900 0.00 72 0.940 P20933 G252E Disease 0.796 0.750 0.00 64 0.919 P20933 G252R Disease 0.800 0.819 0.00 65 0.922 P20933 G302R Disease 0.687 0.983 0.07 43 0.874 P20933 R161Q Disease 0.106 0.732 0.37 -17 0.150 P20933 T257I Disease 0.620 0.778 0.00 66 0.901 P20936 C540Y Disease 0.842 0.954 0.00 55 0.944 P21108 E279D Polymorphism 0.436 0.144 0.36 -34 0.207 P21127 R57C Polymorphism NA 0.168 0.16 34 0.031 P21127 A670V Polymorphism NA 0.407 0.67 -7 0.409 P21127 G506S Polymorphism 0.821 0.482 0.14 42 0.731 P21127 K641N Polymorphism 0.187 0.441 0.41 -7 0.248 P21127 R201W Polymorphism NA 0.331 0.00 57 0.373 P21127 V452A Polymorphism 0.996 0.859 0.00 61 0.948 P21217 G5S Polymorphism 0.272 0.145 0.00 1 0.128 P21217 L20R Polymorphism 0.249 0.588 0.00 23 0.464 P21217 W68R Polymorphism 0.975 0.957 0.00 60 0.954 P21217 G170S Polymorphism 0.847 0.812 0.10 55 0.856 P21217 R160C Polymorphism 0.956 0.931 0.00 64 0.955 P21217 R327Q Polymorphism 0.226 0.744 0.58 8 0.384 P21217 T105M Polymorphism 0.413 0.550 0.10 -50 0.465 P21217 V270M Polymorphism 0.543 0.955 0.00 42 0.882 P21291 K108I Polymorphism 0.520 0.594 0.32 30 0.529 P21333 A39G Disease 0.152 0.331 0.08 -24 0.343 P21333 E82V Disease 0.813 0.800 0.00 46 0.878 P21333 A128V Disease 0.574 0.581 0.05 8 0.732 P21333 A200S Disease 0.619 0.901 0.00 21 0.614 P21333 A273P Disease 0.735 0.500 0.01 -16 0.710 P21333 C210F Disease 0.186 0.701 0.16 35 0.381 P21333 D203Y Disease 0.888 0.809 0.01 46 0.894 P21333 E254K Disease 0.779 0.906 0.00 36 0.746 P21333 L172F Disease 0.576 0.857 0.00 30 0.858 P21333 L656F Disease 0.392 0.414 0.04 24 0.429 P21333 M102V Disease 0.326 0.539 0.10 30 0.611 P21333 P207L Disease 0.907 0.813 0.00 41 0.887 P21333 Q170P Disease 0.710 0.564 0.06 36 0.785 P21333 R196G Disease 0.453 0.653 0.04 44 0.790 P21333 R196W Disease 0.793 0.782 0.01 48 0.877 P21333 S149F Disease 0.660 0.581 0.01 43 0.788 P21333 T555K Disease 0.664 0.549 1.00 23 0.747 P21333 V320A Polymorphism NA 0.325 0.01 18 0.419 P21333 V528M Disease 0.364 0.449 0.04 28 0.442 P21333 V552A Polymorphism 0.510 0.347 0.01 22 0.597 P21333 A1188T Disease 0.500 0.517 0.44 15 0.448 P21333 A1419G Polymorphism 0.408 0.404 0.08 32 0.440 P21333 A1764T Disease 0.141 0.211 0.59 9 0.216 P21333 C1645F Disease 0.725 0.486 0.04 60 0.864 P21333 D1159A Disease 0.503 0.737 0.01 21 0.593 P21333 D1184E Disease 0.329 0.795 0.62 4 0.496 P21333 G1728C Disease 0.821 0.840 0.01 36 0.874 P21333 P1291L Disease 0.213 0.332 0.03 28 0.350 P21333 S1186L Disease 0.450 0.537 0.15 26 0.575 P21333 S1199L Disease 0.246 0.363 0.06 3 0.343 P21359 C93Y Disease 0.923 0.686 0.00 28 0.831 P21359 H31R Disease 0.253 0.100 0.00 27 0.130 P21359 S82F Disease 0.872 0.434 0.00 48 0.620 P21359 Y80C Polymorphism 0.893 0.500 0.00 41 0.696 P21359 Y80S Polymorphism 0.768 0.568 0.00 27 0.734 P21359 C324R Disease 0.700 0.583 0.00 43 0.733 P21359 D186V Disease 0.881 0.586 0.00 37 0.750 P21359 D338G Disease 0.383 0.529 0.00 43 0.537 P21359 E337V Disease 0.394 0.148 0.00 -3 0.263 P21359 G629R Disease 0.298 0.083 0.00 50 0.116 P21359 G848E Disease 0.125 0.513 0.00 50 0.580 P21359 H781P Disease 0.708 0.156 0.00 24 0.351 P21359 I117S Disease 0.797 0.466 0.00 14 0.641 P21359 I157N Disease 0.881 0.405 0.00 38 0.601 P21359 I581T Disease 0.677 0.225 0.00 14 0.513 P21359 K583R Disease 0.127 0.064 0.00 -4 0.077 P21359 L145P Disease NA 0.535 0.00 60 0.782 P21359 L194R Disease 0.868 0.397 0.00 44 0.596 P21359 L216P Disease 0.833 0.716 0.00 16 0.850 P21359 L357P Disease 0.715 0.469 0.00 46 0.647 P21359 L508P Disease 0.720 0.485 0.00 23 0.686 P21359 L532P Disease 0.900 0.575 0.00 57 0.919 P21359 L549P Disease 0.901 0.729 0.00 47 0.895 P21359 L578R Disease 0.869 0.306 0.00 50 0.558 P21359 L604V Disease 0.551 0.340 0.00 25 0.583 P21359 L695P Disease 0.439 0.709 0.00 48 0.817 P21359 L763P Disease 0.893 0.710 0.00 47 0.889 P21359 L844F Disease 0.316 0.446 0.00 39 0.575 P21359 L844P Disease 0.460 0.740 0.00 44 0.768 P21359 L844R Disease 0.313 0.611 0.00 59 0.723 P21359 L847P Disease 0.398 0.622 0.00 46 0.719 P21359 L898P Disease 0.893 0.419 0.00 48 0.602 P21359 L920P Disease 0.893 0.286 0.00 43 0.544 P21359 M968R Disease 0.797 0.327 0.00 38 0.575 P21359 P678L Polymorphism NA 0.118 0.00 -10 0.175 P21359 R765H Polymorphism 0.531 0.217 0.00 26 0.371 P21359 R873C Disease 0.489 0.160 0.00 51 0.310 P21359 S574R Disease 0.482 0.365 0.00 58 0.671 P21359 S665F Disease NA 0.085 0.00 -1 0.092 P21359 T780K Disease 0.756 0.230 0.00 15 0.522 P21359 W777S Disease 0.884 0.525 0.00 23 0.823 P21359 W784C Disease 0.941 0.564 0.00 46 0.870 P21359 W784R Disease 0.885 0.574 0.00 38 0.805 P21359 Y489C Disease 0.848 0.139 0.00 40 0.236 P21359 Y491C Disease 0.105 0.089 0.00 -5 0.077 P21359 A1785S Disease NA 0.421 0.09 -14 0.462 P21359 D2012N Disease NA 0.410 0.00 12 0.462 P21359 E2357K Disease NA 0.230 0.09 47 0.365 P21359 F1193C Disease NA 0.471 0.01 21 0.533 P21359 G1166D Disease NA 0.290 0.05 37 0.289 P21359 G2001R Disease NA 0.358 0.02 30 0.484 P21359 I1605V Disease NA 0.043 0.00 -25 0.219 P21359 K1430E Disease NA 0.470 0.06 11 0.420 P21359 K1440Q Disease NA 0.510 0.32 1 0.493 P21359 K1440R Disease NA 0.292 0.39 14 0.393 P21359 K1444E Disease NA 0.947 0.00 25 0.839 P21359 K1444N Disease NA 0.965 0.00 31 0.845 P21359 K1444R Disease NA 0.886 0.03 11 0.756 P21359 L1147P Disease NA 0.279 0.00 42 0.401 P21359 L1196R Disease NA 0.586 0.00 39 0.731 P21359 L1243P Disease NA 0.979 0.00 46 0.877 P21359 L1446P Disease NA 0.912 0.00 39 0.838 P21359 L1953P Disease NA 0.600 0.00 40 0.730 P21359 L2088P Disease NA 0.866 0.00 59 0.884 P21359 L2164M Disease NA 0.232 0.18 31 0.302 P21359 M1035R Disease 0.797 0.398 0.00 28 0.604 P21359 M1073V Disease 0.539 0.119 0.01 -12 0.281 P21359 N1156S Disease NA 0.607 0.00 21 0.715 P21359 N1451T Disease NA 0.866 0.02 8 0.760 P21359 P2221A Disease NA 0.271 0.03 31 0.281 P21359 R1204G Disease NA 0.671 0.03 28 0.537 P21359 R1204W Disease NA 0.789 0.01 24 0.774 P21359 R1250P Disease NA 0.885 0.00 54 0.835 P21359 R1276G Disease NA 0.948 0.00 47 0.882 P21359 R1276P Disease NA 0.972 0.00 47 0.881 P21359 R1276Q Disease NA 0.951 0.00 50 0.894 P21359 R1412S Disease NA 0.952 0.00 23 0.830 P21359 R1611W Disease NA 0.555 0.00 45 0.736 P21359 S1489G Disease NA 0.270 0.08 28 0.331 P21359 T2507I Disease NA 0.079 0.00 16 0.114 P21359 T2631A Disease NA 0.220 0.00 34 0.366 P21359 V1453L Disease NA 0.463 0.05 6 0.379 P21359 V2511L Polymorphism NA 0.044 0.00 13 0.035 P21359 W1952R Disease NA 0.730 0.04 35 0.740 P21359 Y1422H Polymorphism NA 0.222 0.38 14 0.201 P21359 Y2192N Disease NA 0.137 0.00 29 0.205 P21397 F314V Polymorphism 0.609 0.795 0.07 57 0.742 P21397 K520R Polymorphism NA 0.213 0.13 28 0.187 P21439 D87E Polymorphism 0.309 0.378 1.00 -33 0.254 P21439 P95S Polymorphism NA 0.274 0.90 10 0.319 P21439 A546D Disease 0.985 0.939 0.00 48 0.954 P21439 A934T Disease 0.623 0.352 0.58 -22 0.547 P21439 D564G Disease 0.997 0.837 0.00 65 0.970 P21439 E395G Disease 0.862 0.558 0.02 39 0.811 P21439 F165I Disease 0.974 0.784 0.07 60 0.924 P21439 F711S Disease 0.410 0.446 0.19 32 0.411 P21439 G535D Disease 0.958 0.900 0.01 69 0.951 P21439 G742S Polymorphism 0.361 0.332 0.69 -8 0.242 P21439 G762E Disease 0.977 0.470 0.26 44 0.828 P21439 G983S Disease 0.334 0.308 0.84 -39 0.256 P21439 I263V Polymorphism 0.364 0.737 0.17 6 0.305 P21439 I541F Disease 0.959 0.939 0.05 46 0.937 P21439 L238V Polymorphism 0.478 0.453 0.58 -54 0.262 P21439 L556R Disease 0.992 0.941 0.00 65 0.973 P21439 L591Q Disease 0.988 0.892 0.00 62 0.966 P21439 M301T Disease 0.349 0.500 0.42 -26 0.201 P21439 R150K Disease 0.811 0.917 0.01 49 0.692 P21439 R590Q Polymorphism 0.924 0.906 0.20 62 0.903 P21439 R652G Polymorphism 0.489 0.500 0.34 20 0.433 P21439 R788Q Polymorphism 0.896 0.895 0.11 53 0.864 P21439 S320F Disease 0.802 0.586 0.78 27 0.686 P21439 S346I Disease 0.756 0.596 0.01 -5 0.653 P21439 T424A Disease 0.680 0.460 0.61 23 0.613 P21439 T651N Polymorphism 0.419 0.267 0.50 -32 0.299 P21439 V425M Disease 0.899 0.533 0.01 0 0.775 P21439 W138R Disease 0.924 0.821 0.31 55 0.854 P21439 P1168S Disease 0.779 0.680 0.23 18 0.629 P21452 I23T Polymorphism 0.107 0.228 0.47 -19 0.177 P21452 R375H Polymorphism 0.105 0.130 0.16 36 0.147 P21453 S15L Polymorphism 0.074 0.087 0.32 30 0.064 P21453 A115T Polymorphism 0.104 0.151 0.59 -3 0.114 P21462 I11T Polymorphism NA 0.179 0.64 -18 0.179 P21506 Q227R Polymorphism 0.271 0.412 1.00 36 0.312 P21549 G41R Disease 0.598 0.890 0.04 51 0.588 P21549 G41V Disease 0.385 0.771 0.21 32 0.645 P21549 G82E Disease 0.918 0.972 0.01 73 0.935 P21549 N22S Polymorphism 0.166 0.253 0.88 -24 0.169 P21549 D183N Disease 0.949 0.913 0.00 75 0.936 P21549 F152I Disease 0.404 0.440 0.63 -12 0.238 P21549 G116R Disease 0.355 0.798 0.13 28 0.638 P21549 G156R Disease 0.586 0.868 0.15 66 0.906 P21549 G170R Disease 0.764 0.768 0.02 26 0.678 P21549 I244T Disease 0.386 0.584 0.04 36 0.728 P21549 I340M Polymorphism 0.306 0.211 0.24 -50 0.052 P21549 R233C Disease 0.875 0.689 0.01 61 0.913 P21549 R233H Disease 0.660 0.511 0.05 38 0.735 P21549 S187F Disease 0.953 0.920 0.00 56 0.935 P21549 S205P Disease 0.739 0.931 0.05 57 0.925 P21580 A125V Polymorphism 0.300 0.479 0.08 7 0.424 P21580 A766P Polymorphism 0.427 0.246 0.00 43 0.226 P21589 M379T Polymorphism 0.174 0.345 0.88 -1 0.169 P21589 T376A Polymorphism 0.229 0.136 0.53 3 0.117 P21675 A297G Polymorphism 0.650 0.217 0.00 11 0.375 P21695 I54V Polymorphism 0.484 0.414 0.01 36 0.474 P21695 A113P Polymorphism 0.783 0.926 0.01 -6 0.723 P21695 V197A Polymorphism 0.728 0.755 0.01 22 0.714 P21709 A585T Polymorphism 0.013 0.426 0.40 -38 0.177 P21709 P697L Polymorphism 0.508 0.887 0.07 29 0.605 P21709 R351C Polymorphism 0.733 0.480 0.00 47 0.755 P21709 R492Q Polymorphism 0.083 0.200 0.18 16 0.182 P21709 R575Q Polymorphism 0.313 0.397 0.29 14 0.426 P21709 S807R Polymorphism 0.955 0.939 0.00 70 0.945 P21728 R50S Polymorphism 0.424 0.441 0.01 26 0.489 P21728 T37P Polymorphism 0.706 0.923 0.05 37 0.872 P21728 T37R Polymorphism 0.724 0.908 0.03 59 0.928 P21728 S199A Polymorphism 0.922 0.333 0.00 -1 0.627 P21731 C68S Polymorphism 0.528 0.309 0.79 -21 0.507 P21731 E94V Polymorphism 0.495 0.366 0.07 34 0.437 P21731 A160T Polymorphism 0.716 0.287 0.26 -7 0.538 P21731 V176E Polymorphism 0.638 0.527 0.03 48 0.828 P21731 V217I Polymorphism 0.081 0.055 0.69 -6 0.060 P21754 G31R Polymorphism NA 0.217 0.50 27 0.331 P21754 M340V Polymorphism 0.185 0.077 0.39 -7 0.057 P21754 S315P Polymorphism 0.294 0.430 0.76 -38 0.203 P21757 P275A Polymorphism 0.671 0.344 0.02 25 0.508 P21757 T269I Polymorphism 0.517 0.183 0.01 31 0.370 P21802 R6P Polymorphism NA 0.491 0.28 -6 0.510 P21802 S57L Polymorphism 0.064 0.083 0.30 -6 0.058 P21802 A172F Disease 0.877 0.692 0.01 25 0.818 P21802 A337P Disease 0.764 0.920 0.08 32 0.867 P21802 A344G Disease 0.660 0.926 0.15 54 0.906 P21802 A344P Disease 0.795 0.952 0.04 57 0.935 P21802 A362S Disease 0.227 0.272 0.72 -43 0.229 P21802 A628T Disease 0.710 0.939 0.00 45 0.883 P21802 A648T Disease 0.710 0.697 0.21 13 0.523 P21802 C278F Disease 0.942 0.945 0.01 69 0.925 P21802 C278Y Disease 0.953 0.975 0.00 71 0.946 P21802 C342F Disease 0.938 0.930 0.10 66 0.936 P21802 C342G Disease 0.847 0.960 0.01 62 0.937 P21802 C342R Disease 0.931 0.929 0.00 72 0.939 P21802 C342S Disease 0.838 0.919 0.00 59 0.932 P21802 C342W Disease 0.975 0.948 0.01 71 0.949 P21802 C342Y Disease 0.950 0.975 0.03 68 0.944 P21802 D321A Disease 0.277 0.814 0.37 32 0.588 P21802 E565G Disease 0.729 0.894 0.00 52 0.892 P21802 F276V Disease 0.610 0.563 0.12 44 0.569 P21802 G338E Disease 0.908 0.946 0.00 68 0.938 P21802 G338R Disease 0.930 0.929 0.00 70 0.936 P21802 G384R Disease 0.744 0.861 0.38 38 0.862 P21802 G613R Polymorphism 0.927 0.878 0.00 61 0.924 P21802 G663E Disease 0.902 0.775 0.00 66 0.901 P21802 I288S Disease 0.861 0.882 0.00 46 0.894 P21802 K292E Disease 0.618 0.902 0.13 45 0.818 P21802 K526E Disease 0.763 0.400 0.04 -14 0.537 P21802 K641R Disease 0.600 0.870 0.00 57 0.842 P21802 M186T Polymorphism 0.293 0.090 0.62 0 0.134 P21802 N331I Disease 0.922 0.824 0.00 66 0.920 P21802 N549H Disease 0.904 0.628 0.01 41 0.855 P21802 P253R Disease 0.788 0.699 0.41 27 0.748 P21802 P263L Disease 0.928 0.764 0.12 20 0.809 P21802 Q289P Disease 0.819 0.870 0.06 43 0.873 P21802 R678G Disease 0.853 0.113 0.01 35 0.347 P21802 S252F Disease 0.916 0.696 0.13 1 0.842 P21802 S252L Disease 0.863 0.560 0.42 -8 0.776 P21802 S252W Disease 0.971 0.794 0.03 35 0.852 P21802 S267P Disease 0.547 0.764 0.03 52 0.842 P21802 S347C Disease 0.838 0.548 0.08 51 0.881 P21802 S351C Disease 0.820 0.470 0.01 42 0.715 P21802 S354C Disease 0.834 0.668 0.03 53 0.875 P21802 S354Y Disease 0.877 0.842 0.05 58 0.913 P21802 S372C Disease 0.693 0.296 0.08 21 0.574 P21802 T341P Disease 0.733 0.927 0.03 56 0.910 P21802 V359F Disease 0.786 0.755 0.00 55 0.749 P21802 W290C Disease 0.966 0.959 0.00 75 0.953 P21802 W290G Disease 0.906 0.973 0.00 65 0.938 P21802 W290R Disease 0.935 0.945 0.00 76 0.944 P21802 Y105C Disease 0.689 0.903 0.00 70 0.910 P21802 Y281C Disease 0.941 0.477 0.05 59 0.836 P21802 Y301C Disease NA 0.197 0.17 23 0.337 P21802 Y328C Disease 0.596 0.263 0.16 35 0.571 P21802 Y340C Disease 0.928 0.897 0.00 60 0.936 P21802 Y340H Disease 0.777 0.886 0.00 72 0.917 P21802 Y375C Disease 0.850 0.513 0.14 39 0.803 P21815 E270D Polymorphism 0.093 0.317 0.33 21 0.161 P21815 R219G Polymorphism 0.039 0.297 0.39 -4 0.097 P21815 T256A Polymorphism 0.254 0.220 0.00 9 0.176 P21817 C35R Disease 0.918 0.883 0.00 56 0.939 P21817 L13R Disease 0.876 0.715 0.00 62 0.924 P21817 L13V Disease 0.587 0.478 0.00 50 0.517 P21817 R44C Disease 0.948 0.596 0.00 54 0.924 P21817 A291T Polymorphism 0.164 0.389 0.01 19 0.417 P21817 D166N Disease 0.800 0.779 0.01 59 0.913 P21817 D227V Disease 0.544 0.658 0.00 26 0.731 P21817 D544Y Disease 0.857 0.767 0.01 36 0.864 P21817 E160G Disease 0.828 0.387 0.00 30 0.632 P21817 G165R Disease 0.937 0.651 0.00 63 0.934 P21817 G215E Disease 0.918 0.850 0.00 43 0.887 P21817 G248R Disease 0.580 0.500 0.00 44 0.753 P21817 G341R Disease 0.937 0.593 0.00 47 0.855 P21817 I403M Disease 0.792 0.464 0.00 -4 0.520 P21817 M226K Disease 0.381 0.479 0.01 40 0.582 P21817 R109W Disease 0.958 0.713 0.00 47 0.894 P21817 R163C Disease 0.960 0.589 0.01 44 0.805 P21817 R163L Disease 0.882 0.599 0.02 34 0.817 P21817 R177C Disease 0.960 0.702 0.00 48 0.893 P21817 R328W Disease 0.899 0.242 0.00 46 0.586 P21817 R367L Disease 0.694 0.371 0.03 22 0.618 P21817 R401C Disease 0.960 0.566 0.00 46 0.812 P21817 R401H Disease 0.906 0.543 0.01 37 0.727 P21817 R401S Disease 0.866 0.708 0.01 34 0.767 P21817 R530H Disease 0.515 0.681 0.00 22 0.734 P21817 R533C Disease 0.891 0.749 0.00 50 0.905 P21817 R533H Disease 0.757 0.630 0.20 47 0.702 P21817 R552W Disease 0.919 0.538 0.01 47 0.856 P21817 R614C Disease 0.943 0.579 0.00 37 0.765 P21817 R614L Disease 0.833 0.636 0.01 29 0.750 P21817 Y178C Disease 0.956 0.481 0.01 41 0.680 P21817 Y522S Disease 0.894 0.811 0.00 35 0.876 P21817 A1352G Disease 0.310 0.112 0.02 -8 0.145 P21817 A2350T Disease 0.739 0.395 0.00 35 0.635 P21817 A2367T Disease 0.281 0.385 0.00 -15 0.515 P21817 A2421P Disease 0.473 0.784 0.00 27 0.767 P21817 A2428T Disease 0.512 0.350 0.25 -21 0.428 P21817 A2437V Disease 0.802 0.528 0.00 10 0.751 P21817 A3118V Polymorphism NA 0.103 0.11 5 0.183 P21817 A4846V Disease 0.617 0.345 0.08 25 0.600 P21817 A4906V Disease 0.614 0.508 0.04 44 0.596 P21817 A4940T Disease 0.748 0.301 0.20 31 0.605 P21817 D2129E Disease 0.445 0.537 0.00 28 0.720 P21817 D2431N Disease 0.798 0.709 0.00 -8 0.724 P21817 D2730G Disease NA 0.410 0.04 32 0.438 P21817 D4939E Disease 0.731 0.914 0.00 38 0.790 P21817 E2344D Disease 0.692 0.524 0.00 19 0.747 P21817 E2348G Disease 0.826 0.454 0.00 33 0.672 P21817 E2404K Disease 0.286 0.160 0.16 -12 0.268 P21817 E2779K Polymorphism NA 0.281 0.11 4 0.317 P21817 E2880K Disease NA 0.768 0.00 38 0.644 P21817 E3290K Disease NA 0.363 0.00 3 0.493 P21817 E3583Q Polymorphism NA 0.086 0.04 9 0.144 P21817 F4684S Disease 0.899 0.851 0.00 15 0.887 P21817 G1704S Disease 0.655 0.480 0.00 39 0.659 P21817 G1832A Polymorphism 0.054 0.338 0.05 11 0.456 P21817 G2434R Disease 0.901 0.587 0.00 28 0.730 P21817 G3806R Disease NA 0.566 0.00 50 0.728 P21817 G4638D Disease 0.791 0.703 0.06 52 0.887 P21817 G4891R Disease 0.489 0.980 0.00 63 0.939 P21817 G4897V Disease 0.934 0.930 0.00 52 0.944 P21817 G4899E Disease 0.744 0.928 0.00 59 0.886 P21817 G4899R Disease 0.804 0.923 0.00 63 0.939 P21817 G4942V Disease 0.939 0.774 0.00 31 0.876 P21817 H4651P Disease 0.596 0.824 0.00 58 0.910 P21817 I2321V Polymorphism 0.115 0.259 0.38 0 0.198 P21817 I3916M Disease 0.712 0.481 0.00 17 0.648 P21817 I4898T Disease 0.811 0.813 0.00 46 0.877 P21817 I4938M Disease 0.796 0.893 0.00 7 0.871 P21817 I4938T Disease 0.812 0.919 0.00 20 0.854 P21817 K4724Q Disease 0.785 0.644 0.00 17 0.740 P21817 K4876R Disease 0.647 0.471 0.01 46 0.648 P21817 L2550V Polymorphism NA 0.483 0.00 3 0.439 P21817 L4650P Disease 0.610 0.844 0.00 63 0.918 P21817 L4793P Disease 0.865 0.952 0.09 62 0.933 P21817 L4814F Disease 0.768 0.924 0.00 44 0.834 P21817 L4824P Disease 0.674 0.983 0.00 58 0.930 P21817 L4838V Disease 0.713 0.492 0.00 30 0.712 P21817 M2101K Polymorphism 0.138 0.349 0.00 0 0.317 P21817 M2423K Disease 0.675 0.696 0.00 41 0.845 P21817 N2342S Disease 0.791 0.493 0.00 24 0.667 P21817 P1787L Polymorphism 0.514 0.194 0.00 30 0.447 P21817 P3527S Disease NA 0.481 0.04 -14 0.473 P21817 P4501L Disease 0.336 0.157 0.08 11 0.237 P21817 P4973L Disease 0.931 0.678 0.00 32 0.821 P21817 Q3756E Polymorphism NA 0.086 1.00 -29 0.055 P21817 R1043C Disease 0.958 0.727 0.00 51 0.921 P21817 R2163C Disease 0.959 0.648 0.00 63 0.951 P21817 R2163H Disease 0.905 0.566 0.00 64 0.889 P21817 R2163P Disease 0.915 0.796 0.00 65 0.933 P21817 R2336H Disease 0.904 0.644 0.00 44 0.803 P21817 R2355C Disease 0.735 0.454 0.00 35 0.647 P21817 R2435H Disease 0.856 0.580 0.00 -14 0.658 P21817 R2435L Disease 0.818 0.682 0.00 11 0.721 P21817 R2452W Disease 0.970 0.694 0.00 41 0.895 P21817 R2454C Disease 0.959 0.630 0.00 48 0.829 P21817 R2454H Disease 0.904 0.557 0.00 49 0.863 P21817 R2458C Disease 0.959 0.743 0.00 44 0.899 P21817 R2458H Disease 0.904 0.717 0.00 33 0.861 P21817 R2676W Disease NA 0.380 0.00 29 0.514 P21817 R3539H Disease NA 0.539 0.00 33 0.731 P21817 R3772Q Disease NA 0.635 0.00 29 0.738 P21817 R3772W Disease NA 0.710 0.00 41 0.793 P21817 R4136S Disease 0.377 0.325 0.00 6 0.402 P21817 R4558Q Disease 0.379 0.821 0.00 31 0.725 P21817 R4737Q Disease 0.646 0.617 0.01 56 0.800 P21817 R4737W Disease 0.930 0.769 0.00 56 0.915 P21817 R4825C Disease 0.946 0.820 0.00 53 0.894 P21817 R4861C Disease 0.961 0.783 0.00 55 0.906 P21817 R4861H Disease 0.910 0.707 0.00 48 0.874 P21817 R4893Q Disease 0.836 0.942 0.00 50 0.921 P21817 R4893W Disease 0.971 0.976 0.00 57 0.952 P21817 R4914G Disease 0.885 0.968 0.01 64 0.941 P21817 R4914T Disease 0.894 0.941 0.00 69 0.886 P21817 S1342G Polymorphism NA 0.062 1.00 -26 0.009 P21817 S3217P Disease NA 0.671 0.00 55 0.761 P21817 T2206M Disease 0.790 0.541 0.00 36 0.699 P21817 T2206R Disease 0.679 0.529 0.00 51 0.837 P21817 T2787S Disease NA 0.289 0.04 7 0.342 P21817 T4637A Disease 0.377 0.521 0.13 28 0.679 P21817 T4826I Disease 0.808 0.684 0.00 37 0.821 P21817 V2117L Disease 0.361 0.458 0.00 -5 0.423 P21817 V2168M Disease 0.830 0.518 0.00 47 0.804 P21817 V2214I Disease 0.271 0.253 0.01 -10 0.281 P21817 V2280I Disease 0.271 0.218 0.02 14 0.310 P21817 V2346M Disease 0.829 0.459 0.00 44 0.687 P21817 V2509I Polymorphism NA 0.464 0.00 15 0.533 P21817 V4234L Disease NA 0.424 0.02 3 0.407 P21817 V4842M Disease 0.785 0.480 0.00 25 0.681 P21817 V4849I Disease 0.486 0.624 0.02 10 0.498 P21817 Y4796C Disease 0.957 0.940 0.00 65 0.951 P21817 Y4864C Disease 0.960 0.593 0.00 50 0.879 P21854 P234L Polymorphism 0.079 0.500 0.04 29 0.362 P21860 P30L Polymorphism NA 0.135 0.04 22 0.236 P21860 S20Y Polymorphism NA 0.157 0.03 44 0.206 P21860 I744T Polymorphism 0.380 0.355 0.08 -8 0.391 P21860 K998R Polymorphism NA 0.158 0.08 0 0.088 P21860 N385S Polymorphism 0.423 0.158 0.19 -11 0.153 P21860 R683W Polymorphism 0.808 0.489 0.04 0 0.709 P21860 S717L Polymorphism 0.697 0.742 0.03 -39 0.715 P21860 T204I Polymorphism NA 0.271 0.15 2 0.274 P21860 G1271S Polymorphism NA 0.174 0.00 6 0.060 P21860 L1177I Polymorphism NA 0.166 0.00 9 0.118 P21860 R1127H Polymorphism NA 0.155 0.11 40 0.169 P21860 S1119C Polymorphism NA 0.099 0.01 25 0.138 P21860 T1254K Polymorphism NA 0.174 0.00 16 0.045 P21912 A3G Polymorphism NA 0.119 0.49 22 0.104 P21912 A43P Disease NA 0.740 0.13 21 0.736 P21912 G53R Disease NA 0.870 0.44 32 0.718 P21912 K40E Polymorphism NA 0.641 0.12 49 0.694 P21912 L65H Disease 0.707 0.812 0.14 37 0.814 P21912 L65P Disease 0.716 0.896 0.05 -20 0.789 P21912 L87S Disease 0.906 0.885 0.00 55 0.918 P21912 R46G Disease NA 0.880 0.00 61 0.901 P21912 R46Q Disease NA 0.803 0.01 64 0.893 P21912 C101Y Disease 0.973 0.882 0.01 67 0.936 P21912 C192R Disease 0.964 0.907 0.00 86 0.836 P21912 C196Y Disease 0.985 0.908 0.00 76 0.939 P21912 H132P Disease 0.614 0.839 0.08 46 0.877 P21912 I127N Disease 0.944 0.875 0.00 53 0.919 P21912 P197R Disease 0.648 0.877 0.01 72 0.912 P21912 R230C Disease 0.952 0.889 0.01 65 0.930 P21912 R242H Disease 0.462 0.876 0.04 58 0.847 P21912 S100F Disease 0.890 0.894 0.00 55 0.914 P21912 S163P Polymorphism 0.278 0.711 1.00 -25 0.284 P21917 A281P Polymorphism NA 0.181 0.29 6 0.214 P21917 G332S Polymorphism NA 0.107 0.79 49 0.156 P21917 P329A Polymorphism NA 0.061 0.74 30 0.102 P21917 V194G Polymorphism 0.574 0.387 0.00 23 0.681 P21918 L88R Polymorphism 0.951 0.889 0.00 47 0.916 P21918 A286V Polymorphism NA 0.101 0.61 -2 0.194 P21918 F207V Polymorphism NA 0.301 0.21 -4 0.295 P21918 G110E Polymorphism 0.953 0.895 0.00 74 0.909 P21918 N351D Polymorphism 0.998 0.902 0.00 73 0.957 P21918 S233N Polymorphism 0.812 0.591 0.00 41 0.770 P21918 V238I Polymorphism 0.303 0.122 0.08 -11 0.286 P21953 G278S Disease 0.882 0.760 0.77 50 0.802 P21953 H206R Disease 0.431 0.739 0.09 66 0.863 P21953 R183P Disease 0.890 0.916 0.00 65 0.915 P21964 A72S Polymorphism 0.385 0.200 0.08 24 0.330 P21964 C34S Polymorphism 0.144 0.213 0.12 11 0.213 P21964 A102T Polymorphism 0.411 0.161 0.66 -12 0.214 P21964 A146V Polymorphism 0.469 0.816 0.28 7 0.538 P21964 V158M Polymorphism 0.750 0.411 0.02 13 0.527 P21980 P536S Polymorphism 0.214 0.707 0.27 5 0.397 P21980 Q324R Polymorphism 0.196 0.201 0.35 4 0.176 P21980 R214H Polymorphism 0.931 0.920 0.00 60 0.946 P22004 R257C Polymorphism 0.962 0.952 0.00 50 0.956 P22033 G87E Disease 0.867 0.895 0.01 70 0.927 P22033 G94R Disease 0.864 0.893 0.00 60 0.924 P22033 G94V Disease 0.850 0.823 0.00 51 0.903 P22033 P86L Disease 0.729 0.819 0.00 48 0.871 P22033 P95R Disease 0.377 0.568 0.02 42 0.740 P22033 R93H Disease 0.956 0.716 0.06 57 0.932 P22033 A137V Disease 0.612 0.939 0.01 29 0.595 P22033 A191E Disease 0.279 0.788 0.27 49 0.731 P22033 A197E Disease 0.200 0.889 0.02 39 0.476 P22033 A324T Disease 0.598 0.897 0.00 10 0.827 P22033 A377E Disease 0.751 0.930 0.00 45 0.880 P22033 A535P Disease 0.386 0.894 0.27 -10 0.719 P22033 C560Y Disease 0.388 0.910 0.01 42 0.799 P22033 D156N Disease 0.397 0.723 0.02 35 0.747 P22033 D640Y Disease 0.628 0.955 0.00 50 0.908 P22033 F174S Disease 0.615 0.895 0.01 32 0.856 P22033 F573S Disease 0.549 0.859 0.01 18 0.694 P22033 F638I Disease 0.224 0.783 0.03 43 0.707 P22033 G145S Disease 0.293 0.926 0.00 51 0.856 P22033 G158V Disease 0.642 0.873 0.01 54 0.900 P22033 G203R Disease NA 0.802 0.16 35 0.824 P22033 G215C Disease 0.948 0.868 0.04 60 0.921 P22033 G215S Disease 0.841 0.848 0.17 59 0.909 P22033 G291E Disease 0.410 0.813 0.09 18 0.754 P22033 G312V Disease 0.516 0.894 0.01 51 0.881 P22033 G426R Disease 0.489 0.908 0.01 50 0.882 P22033 G427D Disease 0.949 0.920 0.00 71 0.930 P22033 G623R Disease 0.952 0.947 0.01 59 0.953 P22033 G626C Disease 0.774 0.970 0.10 54 0.924 P22033 G630E Disease 0.555 0.946 0.00 65 0.931 P22033 G637E Disease 0.222 0.858 0.33 50 0.812 P22033 G637R Disease 0.188 0.827 0.40 34 0.442 P22033 G642R Disease 0.952 0.948 0.00 75 0.951 P22033 G648D Disease 0.238 0.870 0.53 49 0.500 P22033 G703R Disease 0.634 0.945 0.00 76 0.943 P22033 G717V Disease 0.890 0.920 0.00 64 0.941 P22033 H265Y Disease 0.724 0.874 0.33 63 0.909 P22033 H350Y Disease 0.772 0.845 0.01 70 0.911 P22033 H386N Disease 0.239 0.913 0.34 54 0.854 P22033 H627R Disease 0.172 0.944 0.00 69 0.921 P22033 H678R Disease 0.530 0.940 0.03 73 0.931 P22033 K621N Disease 0.442 0.837 0.03 56 0.741 P22033 L281S Disease 0.863 0.925 0.00 31 0.868 P22033 L305S Disease 0.847 0.907 0.00 39 0.873 P22033 L328F Disease 0.605 0.932 0.01 8 0.832 P22033 L328P Disease 0.903 0.943 0.00 39 0.887 P22033 L347R Disease 0.761 0.934 0.00 58 0.930 P22033 L518P Disease 0.788 0.916 0.00 45 0.882 P22033 L617R Disease 0.543 0.739 0.00 36 0.816 P22033 L685R Disease 0.659 0.906 0.01 51 0.899 P22033 M186V Disease 0.365 0.908 0.03 53 0.669 P22033 M700K Disease 0.520 0.606 0.04 48 0.719 P22033 N189K Disease 0.448 0.932 0.03 65 0.932 P22033 N219Y Disease 0.225 0.836 0.40 43 0.452 P22033 N388H Disease 0.522 0.895 0.28 62 0.899 P22033 P615R Disease 0.555 0.774 0.05 49 0.850 P22033 P615T Disease 0.457 0.777 0.04 38 0.823 P22033 Q109R Disease 0.432 0.909 0.02 59 0.902 P22033 Q218H Disease 0.685 0.829 0.04 62 0.906 P22033 Q293P Disease 0.390 0.819 0.15 -2 0.621 P22033 Q383H Disease 0.521 0.909 0.02 57 0.839 P22033 Q383P Disease 0.563 0.928 0.05 38 0.862 P22033 Q624R Disease 0.264 0.738 0.41 48 0.736 P22033 R108C Disease 0.955 0.932 0.00 66 0.899 P22033 R108G Disease 0.858 0.918 0.02 62 0.923 P22033 R108H Disease 0.894 0.872 0.00 68 0.921 P22033 R228Q Disease 0.319 0.607 0.12 7 0.426 P22033 R369C Disease 0.955 0.906 0.00 66 0.922 P22033 R369H Disease 0.894 0.845 0.00 67 0.919 P22033 R616C Disease 0.821 0.940 0.00 45 0.891 P22033 R694W Disease 0.635 0.869 0.04 47 0.878 P22033 S148L Disease 0.584 0.850 0.01 30 0.842 P22033 S262N Disease 0.544 0.909 0.63 46 0.601 P22033 S306F Disease 0.690 0.967 0.00 40 0.856 P22033 T230I Disease 0.610 0.837 0.04 35 0.851 P22033 T370P Disease 0.709 0.907 0.08 54 0.904 P22033 T566R Disease 0.294 0.799 0.08 36 0.612 P22033 T598A Polymorphism 0.141 0.400 0.76 -68 0.157 P22033 V368D Disease 0.607 0.800 0.17 34 0.828 P22033 V633G Disease 0.516 0.864 0.00 47 0.871 P22033 V669E Disease 0.854 0.875 0.00 62 0.927 P22033 W105R Disease 0.929 0.938 0.00 69 0.936 P22033 Y231N Disease 0.498 0.840 0.06 50 0.866 P22033 Y316C Disease 0.725 0.907 0.00 32 0.879 P22033 Y587C Disease 0.463 0.968 0.04 65 0.934 P22079 D700N Polymorphism 0.375 0.652 0.29 14 0.546 P22079 T105I Polymorphism 0.107 0.300 0.43 3 0.298 P22079 V421M Polymorphism 0.193 0.550 0.25 -49 0.274 P22083 I255V Polymorphism 0.060 0.046 0.68 0 0.022 P22105 G641C Polymorphism NA 0.742 0.03 59 0.886 P22105 R650H Polymorphism NA 0.144 0.15 54 0.326 P22105 S825A Polymorphism NA 0.327 0.71 39 0.432 P22105 G2555S Polymorphism NA 0.174 0.58 42 0.287 P22223 N322I Disease 0.998 0.478 0.00 63 0.970 P22223 Q563H Polymorphism 0.119 0.565 0.62 31 0.145 P22223 R477H Polymorphism 0.096 0.380 0.37 10 0.165 P22223 R503H Disease 0.953 0.620 0.00 59 0.942 P22223 V237M Polymorphism 0.727 0.251 0.15 17 0.586 P22234 K201N Polymorphism 0.348 0.697 0.09 -18 0.532 P22303 V333E Polymorphism 0.882 0.841 0.02 67 0.921 P22304 A68E Disease 0.928 0.936 0.00 59 0.938 P22304 A79E Disease 0.650 0.841 0.01 64 0.909 P22304 A82E Disease 0.835 0.862 0.02 60 0.922 P22304 A82V Disease 0.780 0.834 0.03 47 0.807 P22304 A85S Disease 0.321 0.525 0.79 0 0.376 P22304 A85T Disease 0.372 0.761 1.00 7 0.399 P22304 D45N Disease 0.998 0.909 0.00 78 0.952 P22304 G94D Disease 0.898 0.919 0.00 68 0.933 P22304 L41P Disease 0.927 0.877 0.00 25 0.868 P22304 L73F Disease 0.375 0.761 0.03 13 0.615 P22304 L92P Disease 0.943 0.879 0.00 51 0.925 P22304 N63D Disease 0.613 0.854 0.03 51 0.905 P22304 P86L Disease 0.879 0.898 0.00 54 0.923 P22304 P86Q Disease 0.894 0.885 0.00 61 0.875 P22304 P86R Disease 0.892 0.928 0.00 72 0.935 P22304 R48P Disease 0.773 0.867 0.27 45 0.876 P22304 R88C Disease 0.996 0.926 0.00 77 0.947 P22304 R88G Disease 0.986 0.917 0.00 72 0.952 P22304 R88H Disease 0.993 0.900 0.00 73 0.949 P22304 R88L Disease 0.991 0.907 0.00 71 0.950 P22304 R88P Disease 0.992 0.921 0.00 71 0.951 P22304 R95G Disease 0.535 0.858 0.00 45 0.892 P22304 R95T Disease 0.340 0.819 0.01 45 0.655 P22304 S71N Disease 0.771 0.874 0.02 43 0.890 P22304 S71R Disease 0.851 0.929 0.01 59 0.938 P22304 S87N Disease 0.886 0.906 0.00 55 0.928 P22304 V89F Disease 0.197 0.785 0.01 -17 0.444 P22304 Y54D Disease 0.948 0.854 0.65 61 0.946 P22304 A205P Disease 0.847 0.887 0.05 52 0.916 P22304 A346D Disease 0.441 0.755 0.12 28 0.467 P22304 A346V Disease 0.463 0.725 0.22 15 0.771 P22304 C184F Disease 0.210 0.617 0.71 30 0.278 P22304 C184W Disease 0.641 0.547 0.19 48 0.683 P22304 C422G Disease 0.159 0.527 0.04 35 0.249 P22304 C422R Disease 0.234 0.418 0.12 32 0.388 P22304 C432Y Disease 0.249 0.603 0.02 7 0.454 P22304 D148H Disease 0.595 0.683 0.22 25 0.600 P22304 D198G Disease 0.166 0.813 0.41 36 0.341 P22304 D252N Disease NA 0.236 0.29 -1 0.266 P22304 D269V Disease NA 0.600 0.27 21 0.555 P22304 D308E Disease 0.969 0.925 0.00 66 0.950 P22304 D308N Disease 0.981 0.917 0.00 68 0.951 P22304 D334G Disease 0.998 0.932 0.00 78 0.952 P22304 D334N Disease 0.998 0.930 0.00 81 0.944 P22304 D478G Disease NA 0.480 NA 25 0.406 P22304 D478Y Disease NA 0.561 NA 32 0.523 P22304 E125V Disease 0.517 0.583 0.11 17 0.710 P22304 E341K Disease 0.811 0.925 0.45 53 0.833 P22304 E434K Disease 0.463 0.805 1.00 12 0.544 P22304 E521K Disease 0.714 0.846 NA 43 0.804 P22304 E521V Disease 0.816 0.580 NA 55 0.874 P22304 G134R Disease 0.936 0.943 0.00 76 0.936 P22304 G140V Disease 0.232 0.814 0.02 44 0.640 P22304 G224E Disease 0.966 0.856 0.25 71 0.934 P22304 G336E Disease 0.999 0.946 0.00 76 0.949 P22304 G336R Disease 0.999 0.968 0.00 77 0.949 P22304 G340D Disease 0.963 0.928 0.46 78 0.932 P22304 H138D Disease 0.452 0.856 0.02 70 0.903 P22304 H159P Disease 0.199 0.690 0.20 24 0.367 P22304 H229R Disease 0.992 0.941 0.02 75 0.944 P22304 H229Y Disease 0.990 0.912 0.23 69 0.909 P22304 H335R Disease 0.948 0.929 0.02 81 0.931 P22304 H342Y Disease 0.685 0.841 1.00 58 0.736 P22304 I485K Disease 0.106 0.725 NA 46 0.283 P22304 I485R Disease 0.124 0.533 NA 51 0.488 P22304 K135N Disease 0.999 0.880 0.00 69 0.948 P22304 K135R Disease 0.998 0.866 0.00 58 0.943 P22304 K227M Disease 0.881 0.339 0.08 61 0.820 P22304 K227Q Disease 0.617 0.386 0.45 60 0.650 P22304 K347I Disease 0.965 0.807 0.00 64 0.932 P22304 K347Q Disease 0.896 0.819 0.20 44 0.854 P22304 K347T Disease 0.934 0.819 0.01 62 0.922 P22304 L102R Disease 0.652 0.831 0.02 52 0.764 P22304 L182P Disease NA 0.792 0.21 15 0.509 P22304 L196S Disease 0.241 0.572 0.41 11 0.313 P22304 L221P Disease 0.963 0.943 0.01 44 0.927 P22304 L259P Disease NA 0.677 0.10 16 0.552 P22304 L314P Disease 0.927 0.878 0.00 53 0.918 P22304 L339R Disease 0.957 0.947 0.01 75 0.948 P22304 L403R Disease 0.805 0.861 0.02 69 0.920 P22304 L410P Disease 0.966 0.925 0.03 61 0.949 P22304 N115Y Disease 0.675 0.740 0.01 48 0.705 P22304 N181I Disease NA 0.351 0.17 25 0.409 P22304 N265I Disease NA 0.254 0.12 17 0.356 P22304 P120H Disease 0.951 0.870 0.01 61 0.930 P22304 P120R Disease 0.915 0.924 0.04 62 0.936 P22304 P160R Disease 0.358 0.696 0.54 32 0.531 P22304 P228L Disease 0.972 0.922 0.46 51 0.937 P22304 P228T Disease 0.961 0.885 1.00 59 0.795 P22304 P231L Disease 0.868 0.894 0.03 41 0.862 P22304 P266H Disease NA 0.451 0.03 20 0.421 P22304 P266R Disease NA 0.582 0.04 18 0.507 P22304 P358R Disease 0.926 0.952 0.00 70 0.938 P22304 P467L Disease 0.356 0.447 0.26 6 0.342 P22304 P469H Disease NA 0.409 0.08 49 0.519 P22304 P480L Disease NA 0.506 NA 16 0.528 P22304 P480Q Disease NA 0.513 NA 33 0.556 P22304 P480R Disease NA 0.628 NA 41 0.537 P22304 Q121H Disease 0.717 0.780 0.03 3 0.723 P22304 Q121R Disease 0.463 0.885 0.33 33 0.549 P22304 Q293H Disease 0.560 0.287 0.14 49 0.573 P22304 Q465P Disease 0.645 0.713 0.01 34 0.850 P22304 R313C Disease 0.892 0.872 0.00 46 0.891 P22304 R468G Disease 0.375 0.590 0.10 56 0.654 P22304 R468L Disease 0.371 0.579 0.06 40 0.594 P22304 R468Q Disease 0.238 0.476 0.25 62 0.569 P22304 R468W Disease 0.796 0.718 0.01 61 0.917 P22304 S117Y Disease 0.381 0.800 0.54 -14 0.571 P22304 S132W Disease 0.902 0.763 0.02 37 0.704 P22304 S143F Disease 0.640 0.606 0.07 20 0.625 P22304 S299I Disease 0.710 0.410 0.28 27 0.517 P22304 S333L Disease 0.879 0.948 0.01 54 0.937 P22304 S349I Disease 0.568 0.547 0.10 52 0.685 P22304 S491F Disease 0.807 0.787 NA 17 0.864 P22304 T118I Disease 0.797 0.919 0.06 42 0.825 P22304 T309A Disease 0.412 0.355 0.75 -46 0.191 P22304 W337R Disease 0.942 0.876 0.11 70 0.917 P22304 W345C Disease 0.906 0.940 0.18 75 0.936 P22304 W502C Disease 0.955 0.886 NA 65 0.948 P22304 W502S Disease 0.893 0.798 NA 50 0.916 P22304 Y108C Disease 0.544 0.852 0.16 46 0.754 P22304 Y108S Disease 0.171 0.794 0.45 33 0.216 P22304 Y225D Disease 0.937 0.857 0.17 65 0.912 P22304 Y264N Disease NA 0.450 0.23 26 0.382 P22304 Y348H Disease 0.181 0.642 0.54 18 0.182 P22304 Y490S Disease 0.416 0.760 NA 28 0.727 P22304 Y523C Disease 0.959 0.900 NA 63 0.958 P22309 F83L Disease 0.486 0.184 0.68 -2 0.236 P22309 G71R Disease 0.720 0.653 0.08 -7 0.602 P22309 H39D Disease 0.988 0.938 0.00 77 0.953 P22309 L15R Disease NA 0.690 0.02 25 0.738 P22309 P34Q Disease 0.971 0.853 0.00 58 0.957 P22309 A292V Disease 0.924 0.541 0.06 -12 0.796 P22309 A368T Disease 0.960 0.882 0.01 27 0.913 P22309 A401P Disease 0.995 0.926 0.02 40 0.887 P22309 A478D Disease NA 0.842 0.00 55 0.891 P22309 A511P Polymorphism NA 0.442 0.21 1 0.539 P22309 C177R Disease 0.792 0.878 0.25 56 0.913 P22309 E291V Disease 0.927 0.707 0.00 47 0.886 P22309 G276R Disease 0.994 0.856 0.00 74 0.896 P22309 G308E Disease 0.998 0.953 0.00 76 0.953 P22309 G377V Disease 0.992 0.917 0.00 56 0.958 P22309 G395V Disease 0.959 0.840 0.01 39 0.896 P22309 H376R Disease 0.914 0.663 0.01 43 0.834 P22309 I294T Disease 0.913 0.511 0.00 33 0.794 P22309 K428E Disease NA 0.651 0.08 -27 0.481 P22309 L175Q Disease 0.707 0.435 0.09 11 0.633 P22309 N400D Disease 0.960 0.915 0.01 66 0.955 P22309 P229Q Disease 0.773 0.384 0.53 -8 0.594 P22309 P387S Disease 0.992 0.931 0.00 52 0.956 P22309 Q331R Disease 0.882 0.954 0.00 49 0.912 P22309 Q357R Disease 0.995 0.921 0.00 70 0.907 P22309 R209W Disease 0.998 0.912 0.00 65 0.958 P22309 R336L Disease 0.969 0.926 0.00 47 0.931 P22309 R336Q Disease 0.898 0.758 0.01 39 0.872 P22309 R336W Disease 0.995 0.928 0.00 50 0.955 P22309 R367G Disease 0.774 0.908 0.00 53 0.911 P22309 R403C Disease 0.969 0.918 0.00 48 0.929 P22309 S375F Disease 0.802 0.860 0.03 14 0.814 P22309 S381R Disease 0.994 0.905 0.00 41 0.936 P22309 V225G Disease 0.783 0.442 0.31 -10 0.603 P22309 W354R Disease 0.995 0.905 0.00 75 0.952 P22309 W461R Disease NA 0.884 0.00 63 0.919 P22309 Y486D Disease NA 0.956 0.00 67 0.941 P22310 L48V Polymorphism 0.519 0.132 0.80 -54 0.178 P22310 P24T Polymorphism 0.628 0.213 0.39 -26 0.411 P22310 R11W Polymorphism NA 0.435 0.19 -47 0.259 P22310 I176F Polymorphism 0.553 0.696 0.21 -10 0.466 P22314 M539I Disease 0.194 0.600 0.94 15 0.333 P22314 S547G Disease 0.447 0.353 0.11 -2 0.415 P22413 L91P Disease NA 0.643 0.03 48 0.710 P22413 G342V Disease 0.460 0.814 0.69 18 0.665 P22413 L579F Disease 0.460 0.828 0.02 -16 0.706 P22413 N179S Polymorphism NA 0.484 0.02 37 0.553 P22413 R774C Disease 0.529 0.461 0.06 23 0.608 P22413 R886T Polymorphism NA 0.158 0.26 13 0.139 P22413 S287F Disease 0.736 0.441 0.03 12 0.570 P22413 Y268H Polymorphism 0.911 0.893 0.07 32 0.912 P22413 Y371F Disease 0.455 0.899 0.02 59 0.845 P22455 V10I Polymorphism NA 0.137 0.51 -19 0.018 P22455 D516N Polymorphism 0.772 0.748 0.08 -5 0.686 P22455 G388R Polymorphism 0.172 0.285 0.01 36 0.308 P22455 G426S Polymorphism 0.226 0.132 0.91 -42 0.114 P22455 P136L Polymorphism 0.246 0.081 0.29 1 0.138 P22455 R529Q Polymorphism 0.345 0.423 0.01 -6 0.263 P22455 T179A Polymorphism 0.275 0.243 0.74 6 0.310 P22466 A16V Polymorphism 0.120 0.133 0.36 -45 0.056 P22492 L52F Polymorphism 0.882 0.322 0.01 9 0.610 P22492 Q178K Polymorphism 0.303 0.078 0.26 9 0.046 P22528 T11I Polymorphism 0.292 0.130 0.06 14 0.066 P22557 D159Y Disease 0.864 0.829 0.00 52 0.907 P22557 I476N Disease 0.872 0.657 0.00 45 0.845 P22557 R204Q Disease 0.260 0.119 0.35 -11 0.171 P22557 R411C Disease 0.943 0.850 0.00 57 0.925 P22557 R448Q Disease 0.286 0.469 0.61 -29 0.256 P22557 R452C Disease 0.804 0.743 0.03 28 0.777 P22557 R560H Disease 0.474 0.271 0.14 42 0.418 P22557 T388S Disease 0.971 0.906 0.00 50 0.895 P22557 Y199H Disease 0.958 0.578 0.00 77 0.934 P22570 P352S Polymorphism 0.245 0.755 0.11 0 0.445 P22570 R123Q Polymorphism 0.245 0.827 0.61 -2 0.368 P22570 R251W Polymorphism 0.779 0.784 0.03 29 0.832 P22570 T345M Polymorphism 0.624 0.790 0.03 7 0.721 P22607 G65R Polymorphism 0.064 0.140 0.50 -1 0.131 P22607 A391E Disease 0.217 0.541 0.25 22 0.584 P22607 A441T Polymorphism 0.115 0.095 1.00 -45 0.100 P22607 A717T Polymorphism 0.264 0.331 0.36 -32 0.210 P22607 D513N Disease 0.196 0.243 0.53 -13 0.211 P22607 D646N Polymorphism 0.771 0.664 0.01 33 0.723 P22607 F384L Polymorphism 0.188 0.420 1.00 -33 0.232 P22607 G370C Disease 0.532 0.274 0.20 18 0.534 P22607 G375C Disease 0.708 0.305 0.07 21 0.596 P22607 G380R Disease 0.287 0.563 0.11 47 0.652 P22607 I538V Disease 0.313 0.174 0.19 -1 0.216 P22607 I726F Polymorphism 0.333 0.597 0.03 2 0.572 P22607 K650E Disease 0.761 0.685 0.00 45 0.804 P22607 K650M Disease 0.926 0.565 0.00 36 0.781 P22607 K650Q Disease 0.750 0.467 0.00 33 0.697 P22607 N540K Disease 0.805 0.738 0.03 27 0.730 P22607 N540S Disease 0.765 0.648 0.12 4 0.693 P22607 N540T Disease 0.820 0.678 0.01 26 0.755 P22607 P250R Disease 0.788 0.708 0.30 26 0.743 P22607 R248C Disease 0.958 0.919 0.00 58 0.941 P22607 R621H Disease 0.889 0.882 0.00 61 0.922 P22607 S249C Disease 0.894 0.551 0.06 18 0.759 P22607 S371C Disease 0.662 0.253 0.07 21 0.569 P22607 T338M Polymorphism 0.588 0.656 0.03 52 0.734 P22607 Y373C Disease 0.850 0.304 0.07 16 0.609 P22612 I251N Polymorphism 0.886 0.892 0.00 49 0.912 P22680 D347N Polymorphism 0.379 0.438 0.01 35 0.438 P22681 L620F Polymorphism 0.447 0.081 0.26 20 0.054 P22681 P782L Polymorphism 0.392 0.539 0.01 3 0.563 P22681 V904I Polymorphism NA 0.075 NA -58 0.026 P22692 V42G Polymorphism 0.347 0.569 0.07 0 0.444 P22695 R183Q Polymorphism 0.533 0.409 0.63 49 0.577 P22735 C53S Disease NA 0.396 0.17 32 0.149 P22735 G94D Disease NA 0.141 0.61 8 0.099 P22735 S42Y Disease NA 0.172 0.00 37 0.181 P22735 D102V Disease NA 0.160 0.04 17 0.143 P22735 D132N Polymorphism NA 0.527 0.15 16 0.498 P22735 D430V Disease 0.963 0.914 0.00 70 0.950 P22735 D490G Disease 0.427 0.967 0.00 61 0.928 P22735 D802V Polymorphism NA 0.170 0.00 36 0.146 P22735 E285K Disease 0.327 0.355 0.92 12 0.216 P22735 E520G Disease 0.414 0.367 0.24 13 0.491 P22735 F293V Disease 0.674 0.957 0.00 44 0.858 P22735 F401V Disease 0.361 0.816 0.01 60 0.889 P22735 G144E Disease NA 0.916 0.00 59 0.917 P22735 G144R Disease NA 0.885 0.00 58 0.907 P22735 G218S Disease 0.719 0.848 0.00 31 0.745 P22735 G278R Disease 0.989 0.896 0.00 75 0.947 P22735 G382R Disease 0.964 0.866 0.01 60 0.942 P22735 G392D Disease 0.987 0.831 0.00 68 0.943 P22735 G473S Disease 0.424 0.817 0.00 44 0.750 P22735 I243S Disease 0.484 0.649 0.04 32 0.578 P22735 I304F Disease 0.411 0.739 0.03 27 0.585 P22735 L205Q Disease NA 0.646 0.00 35 0.582 P22735 L366P Disease 0.700 0.732 0.25 30 0.785 P22735 N289T Disease 0.387 0.790 0.13 32 0.625 P22735 N330H Disease 0.909 0.909 0.01 54 0.874 P22735 P249L Disease 0.841 0.930 0.01 40 0.886 P22735 R126C Disease NA 0.526 0.03 17 0.539 P22735 R126H Disease NA 0.253 0.15 -2 0.229 P22735 R142C Disease NA 0.981 0.00 66 0.936 P22735 R142H Disease NA 0.962 0.00 68 0.938 P22735 R142P Disease NA 0.987 0.00 64 0.935 P22735 R143C Disease NA 0.981 0.00 70 0.936 P22735 R143H Disease NA 0.963 0.00 71 0.938 P22735 R225H Disease 0.560 0.113 0.13 -24 0.241 P22735 R225P Disease 0.604 0.596 0.22 8 0.732 P22735 R264Q Disease 0.899 0.940 0.05 50 0.931 P22735 R264W Disease 0.982 0.973 0.01 51 0.946 P22735 R286Q Disease 0.674 0.522 0.48 23 0.757 P22735 R307G Disease 0.495 0.645 0.07 18 0.736 P22735 R307W Disease 0.826 0.702 0.00 26 0.847 P22735 R315C Disease 0.956 0.958 0.10 65 0.951 P22735 R315H Disease 0.896 0.901 0.02 66 0.903 P22735 R315L Disease 0.870 0.957 0.03 61 0.919 P22735 R323Q Disease 0.974 0.957 0.00 67 0.950 P22735 R323W Disease 0.994 0.966 0.00 67 0.950 P22735 R389H Disease 0.986 0.862 0.00 67 0.950 P22735 R389P Disease 0.985 0.948 0.00 71 0.953 P22735 R396H Disease 0.986 0.931 0.00 67 0.954 P22735 R396L Disease 0.983 0.974 0.00 59 0.952 P22735 R396S Disease 0.981 0.963 0.00 56 0.952 P22735 R687C Disease 0.770 0.562 0.18 11 0.683 P22735 R687H Disease 0.560 0.267 0.54 -15 0.529 P22735 R764C Disease 0.920 0.831 0.00 24 0.872 P22735 S160C Disease NA 0.293 0.05 7 0.369 P22735 S272P Disease 0.491 0.760 0.26 3 0.584 P22735 S331P Disease 0.491 0.924 0.17 38 0.865 P22735 S358R Disease 0.979 0.969 0.00 69 0.950 P22735 S755L Polymorphism 0.120 0.382 0.29 3 0.309 P22735 V209F Disease NA 0.800 0.02 58 0.819 P22735 V359M Disease 0.822 0.791 0.11 36 0.840 P22735 V379L Disease 0.430 0.949 0.00 46 0.876 P22735 V383M Disease 0.822 0.915 0.01 40 0.887 P22735 W342R Disease 0.987 0.939 0.00 75 0.954 P22735 Y134C Disease NA 0.629 0.08 62 0.805 P22735 Y276N Disease 0.573 0.843 0.00 50 0.883 P22735 Y365D Disease 0.854 0.836 0.00 50 0.910 P22735 Y544C Disease 0.991 0.929 0.00 75 0.955 P22748 R14W Disease NA 0.457 0.07 -8 0.468 P22748 R219S Disease 0.815 0.720 0.13 25 0.651 P22792 V536M Polymorphism NA 0.168 NA 45 0.051 P22830 G55C Disease 0.083 0.226 0.08 6 0.275 P22830 I71K Disease 0.884 0.850 0.00 44 0.891 P22830 P62R Disease 0.289 0.614 0.05 21 0.688 P22830 C236Y Disease 0.268 0.855 0.00 -6 0.449 P22830 C406S Disease 0.329 0.566 0.00 63 0.677 P22830 C406Y Disease 0.685 0.709 0.00 73 0.830 P22830 E178K Disease 0.242 0.642 1.00 -40 0.221 P22830 F260L Disease 0.306 0.887 0.00 41 0.603 P22830 F417S Disease 0.590 0.453 0.00 34 0.649 P22830 H386P Disease 0.425 0.728 0.30 8 0.705 P22830 I186T Disease 0.745 0.793 0.00 -3 0.679 P22830 K379N Disease 0.395 0.528 0.26 -28 0.411 P22830 L182R Disease 0.353 0.782 0.01 5 0.580 P22830 M267I Disease 0.414 0.817 0.12 12 0.524 P22830 M288K Disease 0.589 0.845 0.00 9 0.569 P22830 P192T Disease 0.774 0.841 0.00 56 0.910 P22830 P334L Disease 0.910 0.912 0.00 46 0.896 P22830 Q139L Disease 0.376 0.887 0.00 37 0.604 P22830 S151P Disease 0.519 0.860 0.24 -9 0.525 P22830 S264L Disease 0.918 0.898 0.01 35 0.889 P22830 T283I Disease 0.536 0.740 0.05 42 0.681 P22830 V362G Disease 0.436 0.642 0.01 1 0.449 P22830 Y191H Disease 0.856 0.926 0.00 67 0.935 P22888 A373V Disease 0.885 0.908 0.00 14 0.897 P22888 A568V Disease NA 0.844 0.50 39 0.639 P22888 A572V Disease NA 0.749 0.00 5 0.562 P22888 A593P Disease NA 0.927 0.04 44 0.849 P22888 C131R Disease 0.619 0.606 0.06 51 0.735 P22888 C343S Disease 0.201 0.926 0.00 61 0.800 P22888 C543R Disease NA 0.884 0.01 59 0.904 P22888 C581R Disease NA 0.949 0.01 74 0.935 P22888 D564G Disease NA 0.844 0.01 53 0.892 P22888 D578E Disease NA 0.915 0.01 58 0.910 P22888 D578G Disease NA 0.950 0.02 56 0.910 P22888 D578Y Disease NA 0.957 0.00 60 0.920 P22888 E354K Disease 0.899 0.964 0.00 60 0.904 P22888 I542L Disease NA 0.875 0.06 10 0.554 P22888 I575L Disease NA 0.791 0.14 14 0.534 P22888 I625K Disease NA 0.894 0.00 63 0.916 P22888 L457R Disease 0.947 0.937 0.00 62 0.952 P22888 M398T Disease 0.859 0.767 0.01 52 0.915 P22888 M571I Disease NA 0.683 0.22 28 0.557 P22888 N284S Polymorphism 0.341 0.576 0.58 12 0.414 P22888 N291S Polymorphism 0.304 0.220 0.64 -28 0.222 P22888 S306N Polymorphism 0.394 0.173 0.51 14 0.154 P22888 S616Y Disease NA 0.924 0.00 59 0.912 P22888 T577I Disease NA 0.923 0.00 34 0.785 P22891 E70K Polymorphism 0.978 0.923 0.00 2 0.927 P22894 S3C Polymorphism NA 0.350 0.07 -50 0.214 P22894 K87E Polymorphism 0.094 0.635 0.17 -60 0.108 P22894 G154E Polymorphism 0.742 0.907 0.19 25 0.778 P22894 V436A Polymorphism 0.210 0.418 0.00 31 0.437 P22897 T167I Polymorphism NA 0.181 0.13 -36 0.245 P23025 P94L Disease 0.688 0.487 0.05 11 0.534 P23025 V97I Polymorphism 0.394 0.057 0.70 -42 0.093 P23025 C108F Disease 0.958 0.952 0.00 73 0.969 P23025 H244R Disease 0.261 0.901 0.00 45 0.744 P23025 L252V Polymorphism 0.147 0.152 1.00 -17 0.100 P23025 Q185H Disease 0.811 0.918 0.01 41 0.867 P23025 R130K Disease 0.230 0.216 0.22 6 0.236 P23025 R228Q Polymorphism 0.234 0.182 0.33 -17 0.227 P23025 V234L Polymorphism 0.168 0.075 0.48 -44 0.095 P23109 P48L Polymorphism 0.567 0.297 0.00 35 0.485 P23109 R388W Disease 0.961 0.962 0.00 52 0.952 P23109 R425H Disease 0.904 0.934 0.00 68 0.948 P23142 H695R Polymorphism 0.085 0.410 0.43 10 0.223 P23142 Q141R Polymorphism NA 0.237 1.00 21 0.249 P23219 P17L Polymorphism 0.464 0.151 NA -63 0.010 P23219 R53H Polymorphism 0.118 0.192 0.17 12 0.154 P23219 K185T Polymorphism 0.192 0.277 0.25 0 0.228 P23219 K341R Polymorphism 0.107 0.465 0.56 9 0.215 P23219 L237M Polymorphism 0.600 0.589 0.19 11 0.579 P23219 V481I Polymorphism 0.105 0.071 0.12 2 0.103 P23276 L597P Polymorphism 0.071 0.869 0.22 0 0.112 P23276 R281W Polymorphism 0.836 0.646 0.03 31 0.787 P23276 T193M Polymorphism 0.383 0.306 0.16 41 0.392 P23280 G70A Polymorphism NA 0.649 0.23 26 0.517 P23280 M68L Polymorphism NA 0.783 1.00 -30 0.366 P23280 S90G Polymorphism 0.100 0.707 0.23 0 0.167 P23280 T55M Polymorphism NA 0.415 0.10 -9 0.357 P23284 V60L Polymorphism 0.130 0.796 0.04 4 0.286 P23327 S43N Polymorphism 0.090 0.036 NA -30 0.022 P23327 S96A Polymorphism 0.257 0.191 0.76 27 0.228 P23352 C163Y Disease 0.784 0.896 0.00 66 0.926 P23352 C172R Disease 0.493 0.932 0.34 70 0.931 P23352 E514K Disease 0.409 0.204 0.04 47 0.366 P23352 F517L Disease 0.208 0.106 0.17 25 0.093 P23352 K666M Polymorphism 0.580 0.168 0.00 41 0.301 P23352 N267K Disease 0.749 0.911 0.01 55 0.912 P23352 N304S Disease 0.312 0.165 0.73 21 0.225 P23352 R262P Disease 0.806 0.993 0.01 55 0.927 P23352 S396L Disease 0.335 0.170 0.08 35 0.307 P23352 W571R Disease 0.338 0.933 0.00 73 0.933 P23368 G450E Polymorphism 0.422 0.444 0.97 -27 0.216 P23378 A283P Disease 0.756 0.605 0.07 20 0.769 P23378 R515S Disease 0.519 0.782 0.01 54 0.858 P23378 S564I Disease 0.627 0.295 0.00 22 0.591 P23381 A54S Polymorphism NA 0.063 0.39 -13 0.064 P23409 A90D Disease 0.616 0.567 0.02 24 0.725 P23409 A112S Disease 0.442 0.939 0.00 23 0.826 P23415 I272N Disease 0.880 0.855 0.00 28 0.892 P23415 K304E Disease 0.869 0.893 0.01 19 0.856 P23415 P278T Disease 0.725 0.881 0.02 31 0.884 P23415 Q294H Disease 0.725 0.447 0.04 11 0.650 P23415 R280H Disease 0.998 0.913 0.00 60 0.953 P23415 R299L Disease 0.677 0.803 0.02 53 0.802 P23415 R299Q Disease 0.590 0.555 0.05 34 0.555 P23415 R428H Disease 0.973 0.959 0.00 73 0.955 P23415 Y307C Disease 0.971 0.917 0.00 62 0.963 P23443 R272C Polymorphism 0.851 0.434 0.04 28 0.668 P23458 N973K Polymorphism 0.265 0.246 0.87 1 0.200 P23467 T1032I Polymorphism NA 0.224 0.15 47 0.363 P23468 Q447E Polymorphism NA 0.277 0.14 42 0.351 P23470 Q639R Polymorphism NA 0.104 0.18 21 0.080 P23471 I3S Polymorphism NA 0.500 0.00 -14 0.530 P23471 G1433D Polymorphism NA 0.076 0.00 1 0.073 P23490 S29G Polymorphism NA 0.208 NA 21 0.027 P23497 E699G Polymorphism NA 0.849 0.02 44 0.863 P23508 S751C Polymorphism 0.579 0.091 0.11 25 0.135 P23515 G21D Polymorphism NA 0.383 0.07 -38 0.406 P23515 V435A Polymorphism NA 0.285 NA 29 0.112 P23526 A89V Disease 0.606 0.896 0.07 3 0.567 P23526 D86G Disease 0.667 0.819 0.01 49 0.891 P23526 R38W Polymorphism 0.880 0.870 0.00 19 0.879 P23526 R49C Disease 0.886 0.904 0.00 37 0.873 P23526 Y143C Disease 0.777 0.769 0.02 50 0.816 P23560 T2I Disease 0.364 0.179 0.10 -42 0.115 P23560 V66M Polymorphism 0.400 0.067 0.22 13 0.159 P23560 R125M Polymorphism 0.930 0.878 0.00 31 0.905 P23760 F45L Disease 0.402 0.748 0.00 49 0.834 P23760 G48R Disease 0.959 0.946 0.00 63 0.954 P23760 G81A Disease 0.928 0.834 0.00 65 0.938 P23760 G99D Disease 0.744 0.903 0.01 54 0.917 P23760 I59F Disease 0.892 0.880 0.00 48 0.899 P23760 I59N Disease 0.960 0.883 0.00 48 0.903 P23760 K85E Disease 0.514 0.876 0.00 60 0.902 P23760 M62V Disease 0.381 0.595 0.01 25 0.720 P23760 N47H Disease 0.751 0.906 0.00 66 0.927 P23760 N47K Disease 0.551 0.913 0.00 61 0.908 P23760 P50L Disease 0.956 0.835 0.00 31 0.901 P23760 R56L Disease 0.923 0.906 0.00 56 0.939 P23760 S73L Disease 0.935 0.599 0.00 50 0.916 P23760 S84F Disease 0.965 0.863 0.00 54 0.947 P23760 V60M Disease 0.906 0.702 0.00 38 0.867 P23760 V78M Disease 0.909 0.695 0.00 63 0.933 P23760 Y90H Disease 0.578 0.828 0.00 63 0.897 P23760 F238S Disease 0.960 0.796 0.00 61 0.949 P23760 Q391H Disease 0.257 0.475 0.14 55 0.461 P23760 R270C Disease 0.984 0.869 0.00 80 0.947 P23760 R271C Disease 0.984 0.870 0.00 82 0.950 P23760 R271G Disease 0.946 0.757 0.00 81 0.943 P23760 R271H Disease 0.964 0.727 0.00 79 0.946 P23760 T315K Polymorphism 0.140 0.365 0.33 39 0.480 P23760 V265F Disease 0.934 0.754 0.00 55 0.935 P23760 W266C Disease 0.987 0.839 0.00 76 0.954 P23769 A164T Polymorphism NA 0.072 0.34 -10 0.065 P23771 G242S Polymorphism 0.490 0.346 0.45 -6 0.274 P23771 W274R Disease 0.735 0.977 0.00 75 0.945 P23786 P50H Disease NA 0.809 0.01 40 0.832 P23786 D213G Disease 0.660 0.635 0.86 27 0.772 P23786 D553N Disease 0.989 0.885 0.00 57 0.940 P23786 E174K Disease NA 0.789 0.07 49 0.696 P23786 F352C Polymorphism 0.918 0.825 0.00 50 0.941 P23786 F383Y Disease 0.138 0.573 0.06 -14 0.133 P23786 F448L Disease 0.621 0.766 0.01 50 0.664 P23786 G549D Disease 0.784 0.929 0.00 38 0.856 P23786 G600R Disease 0.674 0.899 0.21 59 0.910 P23786 M214T Disease 0.823 0.825 0.27 59 0.843 P23786 P227L Disease 0.920 0.778 0.02 37 0.892 P23786 P604S Disease 0.860 0.821 0.00 43 0.837 P23786 Q550R Disease 0.517 0.376 0.51 17 0.566 P23786 R151Q Disease 0.809 0.857 0.11 44 0.803 P23786 R296Q Disease 0.992 0.895 0.00 67 0.949 P23786 R503C Disease 0.579 0.946 0.07 68 0.929 P23786 R631C Disease 0.877 0.708 0.03 3 0.822 P23786 S113L Disease 0.652 0.562 0.03 8 0.762 P23786 V368I Polymorphism 0.195 0.174 0.65 -37 0.120 P23786 Y210D Disease 0.743 0.492 0.26 46 0.731 P23786 Y479F Disease 0.415 0.429 0.07 6 0.371 P23786 Y628S Disease 0.441 0.472 0.39 0 0.345 P23921 K590Q Polymorphism 0.225 0.514 0.27 -37 0.347 P23921 V778A Polymorphism 0.155 0.310 0.45 -22 0.204 P23942 G68R Disease NA 0.946 0.04 78 0.937 P23942 L45F Disease NA 0.206 0.12 52 0.360 P23942 R13W Disease NA 0.729 0.02 67 0.876 P23942 C165Y Disease 0.999 0.958 0.00 66 0.966 P23942 C213R Disease 0.901 0.908 0.00 71 0.952 P23942 C214S Disease 0.776 0.744 0.00 53 0.906 P23942 D157N Disease 0.708 0.750 0.00 50 0.877 P23942 D173V Disease 0.881 0.857 0.00 65 0.946 P23942 F211L Disease 0.590 0.699 0.16 41 0.802 P23942 G167D Disease 0.863 0.879 0.00 68 0.949 P23942 G167S Disease 0.782 0.794 0.00 51 0.905 P23942 G208D Disease 0.572 0.663 0.02 42 0.557 P23942 G266D Disease NA 0.963 0.00 61 0.930 P23942 G305D Disease NA 0.474 0.26 66 0.707 P23942 K153R Disease 0.524 0.630 0.07 27 0.737 P23942 K310R Polymorphism NA 0.120 0.47 27 0.100 P23942 L126R Disease 0.872 0.934 0.00 62 0.951 P23942 L185P Disease 0.899 0.833 0.02 42 0.885 P23942 N244K Disease 0.739 0.718 0.03 48 0.850 P23942 P210R Disease 0.892 0.803 0.00 70 0.944 P23942 P210S Disease 0.815 0.614 0.00 59 0.921 P23942 P216L Disease 0.306 0.388 0.04 10 0.380 P23942 P216S Disease 0.494 0.296 0.15 11 0.442 P23942 R172G Disease 0.618 0.559 0.04 37 0.729 P23942 R220Q Disease 0.747 0.692 0.00 56 0.910 P23942 R220W Disease 0.954 0.761 0.00 56 0.794 P23942 S212G Disease 0.483 0.624 0.01 44 0.718 P23942 S212T Disease 0.341 0.708 0.30 50 0.822 P23942 V268I Disease NA 0.065 1.00 -27 0.023 P23945 A189V Disease 0.883 0.724 0.10 48 0.879 P23945 A419T Disease 0.834 0.731 0.34 15 0.810 P23945 D224V Disease 0.838 0.865 0.13 57 0.835 P23945 D567N Disease NA 0.923 0.02 50 0.735 P23945 I160T Disease 0.340 0.737 0.01 22 0.614 P23945 I545T Disease NA 0.813 0.01 27 0.627 P23945 L601V Disease NA 0.539 0.05 47 0.613 P23945 N680S Polymorphism NA 0.119 0.83 11 0.097 P23945 P348R Disease 0.993 0.836 0.00 61 0.954 P23945 P519T Disease 0.989 0.841 0.00 43 0.918 P23945 R573C Disease NA 0.935 0.00 69 0.935 P23945 S128Y Disease 0.687 0.598 0.04 23 0.759 P23945 S524R Polymorphism NA 0.615 0.07 36 0.526 P23945 T449A Disease 0.457 0.360 0.38 -4 0.313 P23945 T449I Disease 0.685 0.614 0.00 1 0.789 P23946 H66R Polymorphism 0.732 0.853 0.00 78 0.826 P23946 R98H Polymorphism 0.257 0.219 0.10 4 0.261 P23975 V69I Polymorphism 0.445 0.387 0.10 -47 0.362 P23975 A369P Polymorphism 0.530 0.963 0.01 62 0.770 P23975 A457P Disease 0.530 0.943 0.01 33 0.888 P23975 G478S Polymorphism 0.622 0.686 0.29 -67 0.494 P23975 N375S Polymorphism 0.165 0.315 0.49 -36 0.153 P23975 V356L Polymorphism 0.103 0.483 0.74 -64 0.102 P23975 V449I Polymorphism 0.164 0.113 0.56 -54 0.131 P24001 D152N Polymorphism NA 0.228 NA 44 0.272 P24043 R96S Polymorphism 0.400 0.457 0.51 29 0.368 P24043 C527Y Disease 0.956 0.840 0.00 57 0.941 P24043 C862R Disease 0.986 0.822 0.00 40 0.943 P24043 A1945T Polymorphism NA 0.734 0.00 -14 0.567 P24043 A2587V Polymorphism 0.193 0.414 0.35 29 0.270 P24043 K1561Q Polymorphism NA 0.161 0.59 49 0.173 P24043 L2564P Disease 0.763 0.819 0.02 16 0.838 P24043 Y2586H Polymorphism 0.541 0.302 0.19 45 0.532 P24158 T136S Polymorphism 0.059 0.302 0.06 12 0.200 P24158 V119I Polymorphism 0.095 0.042 1.00 -38 0.024 P24298 H14N Polymorphism NA 0.049 1.00 -3 0.062 P24347 E44K Polymorphism NA 0.201 0.06 -35 0.323 P24347 S86P Polymorphism NA 0.743 0.30 -71 0.397 P24347 F182S Polymorphism 0.187 0.892 0.46 36 0.405 P24386 Q471L Disease 0.546 0.272 0.10 20 0.519 P24394 I75F Polymorphism 0.457 0.311 0.13 45 0.375 P24394 I75L Polymorphism 0.200 0.167 0.43 28 0.120 P24394 I75V Polymorphism 0.084 0.051 0.34 -2 0.051 P24394 A492T Polymorphism 0.359 0.067 0.08 -7 0.026 P24394 P675S Polymorphism 0.305 0.106 0.02 4 0.145 P24394 Q576R Polymorphism 0.071 0.067 1.00 -17 0.035 P24394 S503P Polymorphism 0.410 0.110 0.28 15 0.100 P24394 S752A Polymorphism 0.358 0.187 0.00 25 0.176 P24394 S786P Polymorphism 0.666 0.114 0.00 37 0.411 P24530 L7Q Polymorphism NA 0.185 0.11 -3 0.058 P24530 G57S Disease NA 0.103 0.57 6 0.115 P24530 A183G Disease 0.442 0.113 0.13 -5 0.270 P24530 F112V Polymorphism 0.720 0.901 0.29 9 0.798 P24530 F292L Disease 0.569 0.094 0.19 -9 0.221 P24530 M374I Disease 0.250 0.694 0.02 10 0.466 P24530 P383L Disease 0.986 0.915 0.00 48 0.937 P24530 R319W Disease 0.950 0.928 0.00 48 0.906 P24530 S305N Disease 0.114 0.251 0.31 -7 0.215 P24530 T244M Polymorphism 0.327 0.604 0.08 28 0.542 P24530 W276C Disease 0.946 0.646 0.29 35 0.874 P24539 T152M Polymorphism 0.239 0.058 0.11 16 0.035 P24539 T152N Polymorphism 0.159 0.142 0.49 -14 0.050 P24557 L70P Polymorphism 0.824 0.839 0.02 47 0.855 P24557 L82P Disease 0.769 0.820 0.12 6 0.756 P24557 R60H Polymorphism 0.462 0.536 0.14 -7 0.502 P24557 E387K Polymorphism 0.108 0.256 0.05 55 0.207 P24557 E388K Polymorphism 0.290 0.352 0.14 -31 0.287 P24557 G481W Disease 0.984 0.886 0.00 68 0.930 P24557 I331T Polymorphism 0.514 0.524 0.01 31 0.773 P24557 K257E Polymorphism 0.202 0.720 0.17 -1 0.350 P24557 L162I Polymorphism 0.369 0.539 0.00 11 0.524 P24557 L356V Polymorphism 0.407 0.411 0.62 -17 0.464 P24557 L357V Polymorphism 0.407 0.809 0.00 43 0.552 P24557 L487P Disease 0.776 0.817 0.00 50 0.903 P24557 L512P Polymorphism NA 0.912 0.00 -21 0.565 P24557 P511L Polymorphism NA 0.818 0.00 9 0.800 P24557 Q416E Polymorphism 0.092 0.210 0.04 -12 0.152 P24557 R260G Polymorphism 0.531 0.596 0.31 19 0.603 P24557 R412Q Disease 0.874 0.865 0.00 69 0.820 P24557 R424C Polymorphism 0.539 0.664 0.17 9 0.703 P24557 R465Q Polymorphism 0.111 0.357 0.11 27 0.145 P24557 T450N Polymorphism 0.238 0.382 0.25 -53 0.272 P24592 R134L Polymorphism 0.230 0.414 0.44 21 0.304 P24592 R217Q Polymorphism 0.138 0.313 0.26 -32 0.250 P24592 T236P Polymorphism 0.236 0.095 0.16 -54 0.094 P24593 R138W Polymorphism 0.768 0.308 0.00 47 0.595 P24666 K7N Polymorphism NA 0.243 0.14 2 0.371 P24666 S137F Polymorphism 0.725 0.736 0.03 17 0.659 P24723 A19V Polymorphism NA 0.326 0.00 57 0.538 P24723 K65R Polymorphism NA 0.200 0.75 19 0.317 P24723 P612S Polymorphism 0.420 0.545 0.04 19 0.532 P24723 R149Q Polymorphism NA 0.399 0.55 0 0.297 P24723 R359Q Polymorphism 0.288 0.388 0.09 0 0.290 P24723 V374I Polymorphism 0.170 0.092 0.41 -5 0.161 P24752 A5P Polymorphism NA 0.107 0.00 52 0.158 P24752 N93S Disease NA 0.720 0.21 31 0.610 P24752 A301P Disease 0.749 0.924 0.01 54 0.806 P24752 A333P Disease 0.447 0.765 0.04 23 0.776 P24752 A380T Disease 0.567 0.938 0.00 51 0.843 P24752 G152A Disease 0.650 0.847 0.00 60 0.862 P24752 G183R Disease 0.916 0.876 0.03 66 0.889 P24752 G379V Disease 0.911 0.939 0.00 72 0.903 P24752 I312T Disease 0.724 0.619 0.00 50 0.815 P24752 N158D Disease 0.381 0.821 0.07 27 0.681 P24752 T297M Disease 0.627 0.622 0.00 -1 0.680 P24821 D850H Polymorphism NA 0.203 0.10 57 0.492 P24821 Q680R Polymorphism NA 0.174 0.81 36 0.126 P24821 V605I Polymorphism NA 0.113 0.71 23 0.149 P24855 R2S Polymorphism 0.354 0.178 0.02 -47 0.254 P24855 A246P Polymorphism 0.563 0.827 0.24 51 0.880 P24855 C231Y Polymorphism 0.902 0.980 0.00 58 0.939 P24855 G127R Polymorphism 0.823 0.745 0.05 48 0.861 P24855 P154A Polymorphism 0.168 0.839 0.08 28 0.377 P24855 R107G Polymorphism 0.768 0.952 0.00 54 0.940 P24855 R207C Polymorphism 0.974 0.956 0.02 56 0.971 P24903 R98P Polymorphism 0.943 0.945 0.00 66 0.948 P24903 S38P Polymorphism 0.062 0.393 1.00 -50 0.014 P24903 D218N Polymorphism 0.060 0.180 1.00 -24 0.077 P24903 L391P Polymorphism 0.729 0.870 0.11 21 0.861 P24903 P490L Polymorphism NA 0.575 0.05 19 0.525 P24903 Q266H Polymorphism 0.070 0.401 0.00 -7 0.368 P24928 R292C Polymorphism 0.827 0.923 0.01 47 0.890 P24941 V18L Polymorphism 0.994 0.916 0.00 61 0.955 P24941 Y15S Polymorphism 0.979 0.906 0.00 62 0.953 P24941 T290S Polymorphism NA 0.229 0.85 -35 0.215 P25021 N217D Polymorphism 0.154 0.179 1.00 -26 0.107 P25021 V268M Polymorphism 0.335 0.559 0.11 2 0.489 P25024 M31R Polymorphism 0.235 0.331 0.49 -2 0.175 P25024 R71C Polymorphism 0.268 0.631 0.06 49 0.453 P25024 A306T Polymorphism 0.367 0.829 0.08 -19 0.504 P25024 S342L Polymorphism 0.356 0.482 0.15 45 0.569 P25025 R80C Polymorphism 0.268 0.671 0.06 48 0.498 P25054 R99W Disease 0.871 0.124 0.00 35 0.465 P25054 E911G Disease 0.460 0.211 0.13 25 0.354 P25054 G817C Disease 0.780 0.694 0.10 39 0.842 P25054 I880T Disease 0.183 0.439 0.05 -25 0.381 P25054 N942D Disease 0.156 0.217 0.04 6 0.242 P25054 P870S Polymorphism 0.055 0.036 1.00 -33 0.038 P25054 R414C Disease 0.816 0.857 0.00 52 0.913 P25054 S171I Disease 0.603 0.246 0.01 -11 0.548 P25054 S722G Disease 0.699 0.469 0.02 33 0.661 P25054 S784T Disease 0.096 0.089 0.84 -15 0.101 P25054 A1184P Disease 0.427 0.194 0.23 -6 0.140 P25054 A1296V Disease 0.261 0.048 0.10 22 0.074 P25054 E1317Q Polymorphism 0.098 0.164 0.05 28 0.112 P25054 F1197S Disease 0.273 0.201 0.00 -2 0.241 P25054 G1120E Disease 0.132 0.338 0.09 18 0.239 P25054 G1312E Disease 0.154 0.135 0.38 15 0.090 P25054 G2502S Polymorphism NA 0.102 0.46 31 0.034 P25054 I1259T Disease 0.359 0.268 0.00 0 0.232 P25054 I1304V Polymorphism 0.111 0.094 0.83 -4 0.052 P25054 I1307K Polymorphism 0.292 0.167 0.10 0 0.168 P25054 I2738T Disease NA 0.094 1.00 27 0.017 P25054 L2839F Disease NA 0.126 0.01 38 0.285 P25054 N1118D Polymorphism 0.115 0.071 0.05 10 0.049 P25054 P1176L Disease 0.626 0.467 0.00 11 0.528 P25054 R1171C Disease 0.531 0.063 0.04 33 0.055 P25054 R1171H Disease 0.083 0.029 0.52 19 0.011 P25054 R1348W Disease 0.738 0.140 0.00 36 0.384 P25054 R1882T Polymorphism 0.515 0.118 0.05 40 0.161 P25054 S1495G Disease 0.366 0.195 0.01 24 0.292 P25054 S1973T Polymorphism 0.341 0.173 0.58 35 0.187 P25054 S2621C Disease NA 0.102 0.04 22 0.113 P25054 T1292M Polymorphism 0.465 0.053 0.05 29 0.087 P25054 T1313A Disease 0.161 0.042 1.00 -21 0.045 P25054 T1496S Polymorphism 0.300 0.279 0.30 25 0.369 P25054 V1326A Disease 0.168 0.058 1.00 -3 0.051 P25054 V1472I Disease 0.178 0.068 0.03 -2 0.080 P25054 V1822D Polymorphism 0.068 0.144 0.15 30 0.019 P25054 V2499L Polymorphism NA 0.030 0.56 19 0.019 P25063 A57V Polymorphism NA 0.043 NA 0 0.057 P25067 G3R Polymorphism NA 0.164 NA 9 0.017 P25067 G357R Disease 0.631 0.592 0.55 4 0.203 P25067 P575L Disease NA 0.324 0.06 29 0.409 P25067 Q455K Disease 0.246 0.244 0.88 7 0.219 P25067 R155Q Disease 0.489 0.707 0.58 -15 0.182 P25067 R304Q Disease 0.228 0.288 0.08 -5 0.245 P25067 R434H Disease 0.561 0.271 0.22 11 0.459 P25067 T502M Polymorphism 0.236 0.380 0.14 8 0.258 P25067 T645I Polymorphism 0.277 0.276 0.29 26 0.338 P25092 C30R Polymorphism NA 0.541 0.00 54 0.746 P25092 E610K Polymorphism 0.363 0.108 0.94 35 0.137 P25092 I859V Polymorphism 0.145 0.132 0.31 -2 0.152 P25092 R464L Polymorphism NA 0.313 0.28 21 0.331 P25092 Q1045R Polymorphism 0.125 0.072 1.00 3 0.078 P25098 I184T Polymorphism 0.391 0.468 0.59 43 0.390 P25105 N338S Polymorphism 0.052 0.073 0.84 14 0.070 P25106 L219W Polymorphism 0.811 0.570 0.11 25 0.764 P25116 S166G Polymorphism NA 0.118 0.10 -16 0.185 P25116 Y187N Polymorphism 0.965 0.759 0.01 39 0.897 P25189 D35Y Disease 0.852 0.535 0.10 48 0.785 P25189 D60H Disease 0.443 0.228 0.12 18 0.357 P25189 D75V Disease 0.658 0.282 0.27 23 0.495 P25189 D90E Disease 0.360 0.183 1.00 -15 0.243 P25189 E97V Disease 0.767 0.293 0.01 20 0.513 P25189 G93E Disease 0.757 0.801 0.09 27 0.821 P25189 H39P Disease 0.828 0.779 0.20 29 0.802 P25189 H81R Disease 0.876 0.810 0.02 55 0.924 P25189 I30M Disease 0.462 0.395 0.04 16 0.330 P25189 I62F Disease 0.575 0.236 0.12 0 0.370 P25189 I62M Disease 0.541 0.178 0.15 23 0.240 P25189 I89N Disease 0.786 0.515 0.16 19 0.655 P25189 I99T Disease 0.678 0.698 0.01 8 0.716 P25189 K96E Disease 0.605 0.634 0.02 26 0.727 P25189 R98C Disease 0.961 0.969 0.00 62 0.966 P25189 R98H Disease 0.909 0.940 0.00 45 0.839 P25189 R98P Disease 0.918 0.988 0.00 62 0.953 P25189 R98S Disease 0.870 0.933 0.00 53 0.941 P25189 S44F Disease 0.841 0.656 0.01 35 0.743 P25189 S51F Disease 0.743 0.620 0.02 51 0.810 P25189 S54C Disease 0.968 0.917 0.00 52 0.961 P25189 S54P Disease 0.954 0.924 0.00 56 0.956 P25189 S63C Disease 0.835 0.640 0.01 21 0.723 P25189 S63F Disease 0.887 0.611 0.00 28 0.705 P25189 S78L Disease 0.867 0.542 0.07 26 0.652 P25189 S78W Disease 0.972 0.721 0.03 50 0.914 P25189 T34I Disease 0.785 0.862 0.01 39 0.865 P25189 T65A Disease 0.386 0.372 0.18 24 0.421 P25189 T65I Disease 0.752 0.454 0.05 8 0.619 P25189 V32F Disease 0.834 0.925 0.01 63 0.943 P25189 V58F Disease 0.585 0.571 0.02 52 0.766 P25189 V92M Disease 0.519 0.060 0.21 14 0.151 P25189 Y68C Disease 0.911 0.844 0.00 39 0.894 P25189 Y82C Disease 0.974 0.931 0.00 69 0.965 P25189 A221T Disease 0.378 0.245 0.00 32 0.434 P25189 C127Y Disease 0.993 0.965 0.00 68 0.968 P25189 D109N Disease 0.946 0.958 0.00 39 0.793 P25189 D118N Disease 0.517 0.229 0.34 -8 0.401 P25189 D128E Disease 0.713 0.439 0.81 3 0.575 P25189 D128N Disease 0.805 0.489 0.19 32 0.631 P25189 D134E Disease 0.913 0.882 0.00 34 0.927 P25189 D134G Disease 0.950 0.964 0.00 41 0.930 P25189 D134N Disease 0.946 0.909 0.00 52 0.954 P25189 D224Y Disease 0.534 0.552 0.00 48 0.730 P25189 G103E Disease 0.980 0.948 0.00 54 0.966 P25189 G110D Disease 0.777 0.556 0.02 54 0.851 P25189 G123C Disease 0.991 0.967 0.00 58 0.967 P25189 G137S Disease 0.521 0.572 0.73 32 0.492 P25189 G163R Disease 0.964 0.853 0.11 26 0.909 P25189 G167A Disease 0.119 0.305 1.00 -39 0.179 P25189 G167R Disease 0.641 0.597 0.18 46 0.771 P25189 I112T Disease 0.763 0.935 0.00 48 0.888 P25189 I114T Disease 0.812 0.807 0.01 52 0.902 P25189 I135L Disease 0.530 0.527 0.06 37 0.587 P25189 I135T Disease 0.812 0.650 0.01 42 0.761 P25189 I162M Disease 0.630 0.598 0.05 12 0.559 P25189 K130R Disease 0.646 0.647 0.00 16 0.590 P25189 K138N Disease 0.525 0.082 0.45 4 0.082 P25189 K236E Disease 0.352 0.139 0.67 45 0.075 P25189 L170R Disease 0.848 0.761 0.02 51 0.889 P25189 N116H Disease 0.921 0.526 0.01 36 0.829 P25189 N122S Disease 0.918 0.878 0.00 8 0.897 P25189 N131K Disease 0.976 0.907 0.00 45 0.951 P25189 P132L Disease 0.984 0.878 0.00 35 0.863 P25189 R227S Disease 0.117 0.142 0.27 14 0.095 P25189 S140T Disease 0.569 0.285 0.24 10 0.444 P25189 T124K Disease 0.951 0.932 0.00 42 0.927 P25189 T124M Disease 0.975 0.880 0.00 32 0.947 P25189 T139N Disease 0.569 0.179 0.18 -8 0.227 P25189 T143M Disease 0.748 0.121 0.06 12 0.288 P25189 V136E Disease 0.820 0.510 0.34 37 0.648 P25189 V146F Disease 0.952 0.925 0.00 61 0.952 P25189 W101C Disease 0.934 0.961 0.00 61 0.911 P25189 Y145S Disease 0.777 0.476 0.76 -3 0.603 P25205 D280V Polymorphism 0.878 0.781 0.00 32 0.809 P25205 E777K Polymorphism 0.055 0.101 0.46 14 0.133 P25205 F287L Polymorphism 0.119 0.135 1.00 -35 0.084 P25205 I590L Polymorphism 0.530 0.127 0.02 -15 0.351 P25391 L349S Polymorphism NA 0.292 0.05 38 0.408 P25391 V559I Polymorphism 0.357 0.210 0.23 31 0.369 P25391 I2076T Polymorphism NA 0.240 0.51 -23 0.176 P25391 L1591V Polymorphism NA 0.420 0.43 27 0.375 P25391 S1577A Polymorphism NA 0.168 0.31 30 0.225 P25440 A49G Polymorphism NA 0.146 0.13 -28 0.248 P25440 A212P Polymorphism 0.563 0.260 0.12 18 0.447 P25440 A599P Polymorphism 0.251 0.197 0.30 -58 0.184 P25440 P260Q Polymorphism 0.107 0.215 0.36 18 0.242 P25440 R547K Polymorphism 0.078 0.289 1.00 -36 0.164 P25445 A16T Polymorphism NA 0.188 0.12 -9 0.177 P25445 C82R Disease 0.997 0.832 0.00 71 0.961 P25445 T28A Disease NA 0.134 0.20 21 0.113 P25445 A257D Disease 0.340 0.307 0.27 18 0.433 P25445 D260G Disease 0.419 0.397 0.03 25 0.512 P25445 D260V Disease 0.585 0.461 0.00 14 0.631 P25445 D260Y Disease 0.697 0.430 0.01 42 0.631 P25445 E272G Disease 0.227 0.337 0.00 31 0.503 P25445 E272K Disease 0.083 0.625 0.01 39 0.685 P25445 I184V Polymorphism 0.173 0.099 0.87 20 0.075 P25445 I262S Disease 0.141 0.641 0.02 24 0.359 P25445 I310S Disease 0.189 0.748 0.00 14 0.504 P25445 R121W Disease 0.756 0.306 0.06 48 0.588 P25445 R250P Disease 0.273 0.937 0.01 43 0.711 P25445 R250Q Disease 0.139 0.718 0.02 12 0.695 P25445 T122I Polymorphism 0.544 0.427 0.01 35 0.537 P25445 T241K Disease 0.153 0.323 1.00 -6 0.187 P25445 T241P Disease 0.048 0.718 0.15 18 0.263 P25445 T270I Disease 0.069 0.429 0.02 32 0.353 P25445 T305I Polymorphism 0.035 0.143 0.34 2 0.103 P25445 Y232C Disease 0.423 0.785 0.15 53 0.817 P25705 I223V Polymorphism NA 0.186 0.33 -13 0.237 P25774 R113W Polymorphism 0.277 0.606 0.04 -58 0.410 P25774 S161T Polymorphism 0.306 0.448 0.12 9 0.350 P25874 M229L Polymorphism 0.236 0.153 1.00 -15 0.088 P25929 K374T Polymorphism 0.319 0.306 0.24 0 0.369 P25940 A1488P Polymorphism 0.380 0.610 1.00 -54 0.370 P25940 I1594M Polymorphism NA 0.273 0.07 22 0.249 P25940 R1042P Polymorphism NA 0.311 0.36 -13 0.276 P25940 R1207P Polymorphism NA 0.494 0.21 4 0.434 P25940 V1691I Polymorphism NA 0.197 0.49 9 0.269 P25942 C83R Disease 0.976 0.973 0.00 52 0.963 P25942 P227A Polymorphism 0.196 0.070 0.13 -4 0.098 P25942 S124L Polymorphism 0.106 0.097 0.30 6 0.104 P25963 S32I Disease NA 0.195 0.00 19 0.373 P26006 A719T Polymorphism 0.100 0.166 0.29 -4 0.120 P26006 G840S Polymorphism 0.121 0.875 0.22 -8 0.203 P26006 I268F Polymorphism 0.347 0.619 1.00 -46 0.358 P26022 A290V Polymorphism 0.187 0.083 0.47 -3 0.136 P26045 A90P Polymorphism NA 0.390 0.92 14 0.097 P26045 D77N Polymorphism NA 0.254 0.50 40 0.375 P26045 F605L Polymorphism NA 0.112 0.65 -17 0.073 P26358 H97R Polymorphism NA 0.212 0.24 12 0.173 P26358 I311V Polymorphism NA 0.080 1.00 -19 0.017 P26367 A33P Disease 0.926 0.931 0.00 57 0.945 P26367 A79E Disease 0.426 0.819 0.00 36 0.815 P26367 C52R Disease 0.970 0.919 0.00 66 0.954 P26367 G18W Disease 0.986 0.918 0.00 63 0.956 P26367 G64V Disease 0.957 0.868 0.00 50 0.939 P26367 G73D Disease 0.964 0.919 0.00 58 0.953 P26367 I29S Disease 0.927 0.888 0.00 34 0.904 P26367 I29V Disease 0.587 0.605 0.00 26 0.819 P26367 I42S Disease 0.930 0.875 0.00 43 0.891 P26367 I56T Disease 0.895 0.855 0.00 48 0.907 P26367 I87K Disease 0.634 0.901 0.00 45 0.887 P26367 I87R Disease 0.664 0.853 0.00 51 0.900 P26367 L46R Disease 0.960 0.913 0.00 62 0.951 P26367 N17S Disease 0.265 0.789 0.00 45 0.775 P26367 R19P Disease 0.943 0.929 0.00 54 0.946 P26367 R26G Disease 0.912 0.907 0.00 52 0.932 P26367 R44Q Disease 0.917 0.874 0.00 55 0.914 P26367 S43P Disease 0.921 0.936 0.00 50 0.933 P26367 T63P Disease 0.931 0.888 0.00 50 0.932 P26367 V53D Disease 0.966 0.945 0.00 59 0.956 P26367 V53L Disease 0.779 0.808 0.00 34 0.857 P26367 F258S Disease 0.959 0.838 0.00 36 0.918 P26367 G387D Polymorphism NA 0.226 0.08 49 0.435 P26367 M381V Disease 0.087 0.133 0.91 50 0.150 P26367 P375Q Disease 0.340 0.441 0.00 0 0.539 P26367 Q178H Disease NA 0.110 0.10 -2 0.198 P26367 Q422R Disease NA 0.367 0.00 16 0.555 P26367 R125C Disease NA 0.926 0.00 62 0.921 P26367 R128C Disease NA 0.936 0.00 61 0.923 P26367 R208Q Disease 0.460 0.791 0.01 52 0.800 P26367 R208W Disease 0.864 0.845 0.00 58 0.929 P26367 R242T Disease 0.541 0.266 0.03 34 0.591 P26367 S119R Disease NA 0.817 0.00 43 0.833 P26367 S292I Disease 0.355 0.226 0.12 47 0.375 P26367 S353A Disease 0.139 0.185 0.45 45 0.197 P26367 S363P Disease 0.137 0.222 0.39 -16 0.164 P26367 V126D Disease NA 0.827 0.00 63 0.907 P26371 Y40C Polymorphism 0.815 0.505 0.06 19 0.527 P26378 D166G Polymorphism 0.483 0.790 0.05 58 0.788 P26378 P270S Polymorphism NA 0.183 0.40 -20 0.216 P26436 G126R Polymorphism NA 0.321 0.05 25 0.377 P26439 A10E Disease 0.963 0.881 0.01 47 0.935 P26439 A10V Disease 0.900 0.809 0.01 27 0.847 P26439 A82T Disease 0.896 0.919 0.03 41 0.882 P26439 D74N Polymorphism 0.608 0.879 0.04 -31 0.650 P26439 E94Q Polymorphism 0.268 0.666 0.84 -56 0.348 P26439 G15D Disease 0.974 0.948 0.00 66 0.953 P26439 A167V Disease 0.719 0.481 0.15 -16 0.686 P26439 A245P Disease NA 0.916 0.22 -42 0.588 P26439 E142K Disease 0.908 0.886 0.00 2 0.883 P26439 G129R Disease 0.760 0.880 0.09 46 0.845 P26439 G294V Disease NA 0.842 0.01 -43 0.609 P26439 K216E Disease 0.365 0.476 0.86 -18 0.353 P26439 L108W Disease 0.975 0.872 0.00 6 0.899 P26439 L173R Disease 0.635 0.910 0.00 32 0.698 P26439 L205P Disease 0.775 0.801 0.01 10 0.729 P26439 L236S Disease 0.356 0.521 0.25 -70 0.403 P26439 N100S Disease 0.930 0.909 0.00 59 0.948 P26439 P155L Disease 0.713 0.342 0.01 -20 0.591 P26439 P186L Disease 0.632 0.899 0.18 33 0.656 P26439 P222H Disease 0.798 0.370 0.20 0 0.562 P26439 P222Q Disease 0.756 0.500 0.40 -24 0.718 P26439 P222T Disease 0.403 0.407 0.48 -11 0.241 P26439 S213G Disease 0.334 0.443 0.34 -66 0.172 P26439 T259M Disease 0.839 0.387 0.02 20 0.648 P26439 T259R Disease 0.433 0.728 0.21 -11 0.508 P26439 Y253N Disease 0.972 0.933 0.00 54 0.953 P26439 Y254D Disease 0.960 0.833 0.00 54 0.934 P26440 D69N Disease NA 0.856 0.00 47 0.877 P26440 L42P Disease NA 0.919 0.01 18 0.776 P26440 R50P Disease NA 0.964 0.05 61 0.925 P26440 A311V Disease 0.531 0.706 1.00 19 0.763 P26440 C357R Disease 0.683 0.858 0.05 54 0.898 P26440 G199V Disease 0.866 0.839 0.06 57 0.903 P26440 R392C Disease 0.986 0.872 0.00 63 0.932 P26440 R411L Disease 0.616 0.947 0.27 38 0.513 P26440 V371A Disease 0.691 0.217 0.18 2 0.520 P26441 N49S Polymorphism 0.069 0.043 1.00 -5 0.038 P26442 I181V Polymorphism NA 0.063 NA 24 0.046 P26639 G21D Polymorphism NA 0.124 0.69 16 0.054 P26640 R181C Polymorphism NA 0.443 0.00 62 0.646 P26651 P37S Polymorphism NA 0.129 0.66 -20 0.040 P26651 P55S Polymorphism NA 0.087 0.80 -59 0.048 P26651 I259F Polymorphism 0.176 0.080 0.23 46 0.042 P26678 R9C Disease 0.779 0.289 NA 60 0.619 P26717 S2N Polymorphism 0.195 0.020 1.00 -60 0.057 P26842 A59T Polymorphism 0.315 0.132 0.39 44 0.130 P26885 R7Q Polymorphism NA 0.078 0.57 -41 0.065 P26927 C13Y Polymorphism NA 0.454 0.95 17 0.486 P26927 C212F Polymorphism NA 0.849 0.00 61 0.908 P26927 E676K Polymorphism 0.181 0.436 1.00 33 0.379 P26951 A12T Polymorphism NA 0.094 0.93 27 0.080 P26951 E77G Polymorphism NA 0.377 0.07 24 0.196 P26998 G165R Disease 0.956 0.514 0.00 42 0.843 P26998 R105Q Polymorphism 0.873 0.515 0.00 59 0.870 P26998 V159I Polymorphism 0.555 0.313 0.18 12 0.519 P27037 S258R Polymorphism 0.187 0.345 0.08 25 0.337 P27169 R160G Polymorphism 0.453 0.235 0.14 27 0.421 P27216 R86H Polymorphism 0.208 0.553 0.01 -16 0.273 P27216 V108I Polymorphism 0.158 0.218 0.20 0 0.220 P27216 V272I Polymorphism 0.115 0.333 0.51 -25 0.165 P27352 G65R Polymorphism 0.455 0.383 0.11 64 0.294 P27352 Q23R Disease 0.086 0.032 0.80 -8 0.029 P27352 S46L Disease 0.515 0.229 0.28 28 0.368 P27352 N255S Polymorphism 0.174 0.054 0.77 -28 0.061 P27361 E323K Polymorphism NA 0.793 0.03 18 0.640 P27539 A118V Polymorphism NA 0.103 0.53 26 0.091 P27540 D511N Polymorphism 0.188 0.105 0.50 44 0.094 P27540 D517E Polymorphism 0.075 0.245 0.65 -28 0.166 P27540 P706L Polymorphism 0.242 0.203 0.09 32 0.189 P27540 R430Q Polymorphism 0.152 0.856 0.35 48 0.397 P27635 N202S Polymorphism 0.095 0.472 0.52 -4 0.176 P27695 I64V Polymorphism NA 0.155 0.51 3 0.146 P27695 D148E Polymorphism 0.418 0.253 1.00 -11 0.191 P27815 H808Y Polymorphism NA 0.077 0.13 31 0.056 P27816 R23Q Polymorphism NA 0.592 0.00 33 0.718 P27816 I994V Polymorphism 0.265 0.692 0.04 8 0.506 P27816 P366L Polymorphism 0.192 0.172 0.36 20 0.070 P27816 S427Y Polymorphism 0.300 0.284 0.05 33 0.378 P27918 G250S Polymorphism 0.133 0.190 0.69 6 0.162 P27918 G298V Disease 0.697 0.330 0.00 50 0.647 P27918 P204L Polymorphism 0.321 0.252 0.20 25 0.368 P27918 Q343R Disease 0.329 0.150 0.82 21 0.247 P27918 R100W Disease 0.783 0.323 0.00 69 0.918 P27918 Y414D Disease 0.429 0.579 0.30 33 0.492 P27930 E181K Polymorphism 0.079 0.102 1.00 5 0.072 P27986 E451K Polymorphism 0.227 0.233 0.06 33 0.324 P27987 A322T Polymorphism 0.297 0.088 0.17 34 0.059 P27987 P552Q Polymorphism 0.514 0.059 0.13 20 0.036 P28039 D28N Polymorphism NA 0.030 NA -63 0.030 P28039 A166T Polymorphism NA 0.074 NA -19 0.082 P28039 A266G Polymorphism NA 0.600 NA 56 0.762 P28062 T74S Polymorphism 0.705 0.912 0.00 49 0.720 P28065 R60H Polymorphism 0.255 0.447 0.14 -4 0.249 P28065 V32I Polymorphism 0.483 0.755 0.24 10 0.491 P28065 R173C Polymorphism 0.609 0.597 0.01 12 0.670 P28067 G181A Polymorphism 0.290 0.308 0.00 41 0.533 P28067 H162Q Polymorphism 0.263 0.102 0.07 -10 0.157 P28067 R210H Polymorphism 0.369 0.423 0.04 6 0.438 P28067 V166I Polymorphism 0.082 0.201 0.01 3 0.217 P28067 V235M Polymorphism 0.420 0.400 0.01 51 0.689 P28068 D49V Polymorphism 0.430 0.141 0.00 37 0.302 P28068 S45F Polymorphism 0.454 0.330 0.03 45 0.404 P28068 S71N Polymorphism NA 0.135 0.34 -4 0.194 P28068 A162E Polymorphism NA 0.799 0.32 -27 0.492 P28068 A162V Polymorphism NA 0.764 0.52 -34 0.436 P28068 I197T Polymorphism 0.109 0.741 0.62 -5 0.252 P28069 Q4R Polymorphism 0.163 0.401 0.00 29 0.583 P28069 A19V Polymorphism 0.194 0.100 0.01 31 0.122 P28069 P24L Disease 0.405 0.469 0.00 12 0.603 P28069 A158P Disease 0.531 0.925 0.00 16 0.893 P28069 D227Y Polymorphism 0.603 0.735 0.63 45 0.596 P28069 E174G Disease 0.996 0.960 0.00 57 0.960 P28069 F135C Disease 0.992 0.919 0.00 37 0.941 P28069 P239S Disease 0.998 0.899 0.01 55 0.957 P28069 R143Q Disease 0.997 0.931 0.00 65 0.961 P28069 R271W Disease 0.616 0.961 0.00 68 0.941 P28069 W193R Disease 0.998 0.918 0.00 68 0.960 P28070 I234T Polymorphism 0.378 0.763 0.01 37 0.752 P28072 P107A Polymorphism 0.423 0.239 0.21 22 0.372 P28161 S173N Polymorphism 0.093 0.268 0.38 -6 0.156 P28221 S265L Polymorphism 0.155 0.373 0.66 22 0.275 P28222 F124C Polymorphism 0.600 0.217 0.01 15 0.551 P28223 A447V Polymorphism 0.155 0.042 1.00 20 0.080 P28290 P836L Polymorphism 0.034 0.157 0.00 22 0.255 P28290 Y1258N Polymorphism 0.154 0.103 1.00 32 0.072 P28325 C46R Polymorphism 0.532 0.054 0.76 -22 0.012 P28328 E55K Disease 0.538 0.964 0.00 59 0.918 P28329 A120T Polymorphism NA 0.127 0.59 -32 0.201 P28329 E441K Disease 0.509 0.966 0.01 81 0.926 P28329 I305T Disease 0.491 0.531 0.36 -9 0.412 P28329 I336T Disease 0.491 0.890 0.00 0 0.792 P28329 L210P Disease 0.820 0.933 0.06 7 0.860 P28329 L243F Polymorphism 0.372 0.786 0.01 4 0.539 P28329 P211A Disease 0.604 0.189 0.55 8 0.351 P28329 P299L Polymorphism 0.354 0.302 0.20 10 0.375 P28329 R222P Polymorphism 0.115 0.685 0.14 4 0.073 P28329 R420C Disease 0.980 0.958 0.00 67 0.953 P28329 R482G Disease 0.665 0.386 0.02 8 0.624 P28329 R560H Disease 0.993 0.944 0.01 59 0.950 P28329 S498L Disease 0.479 0.527 0.02 4 0.498 P28329 V506L Disease 0.220 0.269 0.18 -7 0.226 P28330 K333Q Polymorphism 0.720 0.669 0.44 -13 0.451 P28332 I114V Polymorphism 0.101 0.063 0.35 -5 0.119 P28332 T151P Polymorphism 0.692 0.952 0.00 41 0.869 P28335 C23S Polymorphism NA 0.229 0.57 5 0.142 P28340 R5W Polymorphism NA 0.167 0.00 43 0.264 P28340 G21C Polymorphism NA 0.087 0.04 9 0.127 P28340 R19H Polymorphism NA 0.110 0.25 23 0.106 P28340 R30W Polymorphism NA 0.098 0.05 32 0.101 P28340 P347L Polymorphism 0.194 0.357 0.32 -4 0.314 P28340 R119H Polymorphism 0.050 0.215 0.41 -13 0.111 P28340 R177H Polymorphism 0.295 0.303 0.07 -9 0.312 P28347 Y421H Disease 0.655 0.930 0.00 70 0.939 P28358 M319K Disease 0.947 0.954 0.00 57 0.951 P28360 E78V Disease NA 0.188 0.24 18 0.316 P28360 G91D Disease NA 0.165 0.63 15 0.220 P28360 M61K Disease 0.067 0.685 0.30 38 0.597 P28360 G116E Disease 0.057 0.539 0.96 13 0.295 P28360 R151S Disease NA 0.500 0.85 29 0.440 P28360 R196P Disease 0.905 0.930 0.00 60 0.920 P28360 V114G Disease 0.149 0.314 0.41 -4 0.278 P28472 G32R Disease NA 0.375 0.39 3 0.400 P28562 A56T Polymorphism NA 0.463 0.22 0 0.496 P28566 S262F Polymorphism NA 0.634 0.28 28 0.775 P28676 S80A Polymorphism 0.078 0.368 0.21 -23 0.194 P28698 I331V Polymorphism NA 0.164 0.59 -12 0.140 P28698 R103H Polymorphism NA 0.114 0.01 24 0.148 P28698 R130Q Polymorphism NA 0.099 0.50 35 0.074 P28698 R441P Polymorphism 0.071 0.301 0.03 36 0.281 P28715 P72H Disease 0.987 0.899 0.00 53 0.961 P28715 A792V Disease 0.920 0.809 0.00 32 0.885 P28715 A874T Disease 0.768 0.921 0.00 28 0.864 P28715 C529S Polymorphism 0.175 0.163 0.57 -3 0.015 P28715 E399K Polymorphism 0.243 0.365 0.42 46 0.348 P28715 F670L Polymorphism 0.214 0.112 0.66 -30 0.062 P28715 H181R Polymorphism 0.363 0.224 0.42 43 0.385 P28715 L858P Disease 0.956 0.956 0.00 61 0.950 P28715 M254V Polymorphism 0.343 0.500 0.19 38 0.554 P28715 N879S Polymorphism 0.226 0.215 0.35 -31 0.167 P28715 Q256R Polymorphism 0.269 0.093 0.19 24 0.175 P28715 Q680R Polymorphism 0.267 0.064 0.08 27 0.096 P28715 S311C Polymorphism 0.930 0.148 0.01 -8 0.501 P28715 V145I Polymorphism 0.215 0.134 0.99 26 0.236 P28715 V590I Polymorphism 0.634 0.114 0.26 9 0.099 P28715 V597L Polymorphism 0.287 0.097 0.26 4 0.036 P28715 A1119V Polymorphism NA 0.148 1.00 30 0.073 P28715 D1104H Polymorphism NA 0.177 0.00 36 0.204 P28715 G1053R Polymorphism 0.263 0.148 0.01 30 0.142 P28715 G1080Q Polymorphism NA 0.096 0.24 -3 0.022 P28715 G1080R Polymorphism NA 0.111 0.06 10 0.014 P28715 R1009H Polymorphism 0.198 0.212 0.30 -33 0.267 P28749 I1035M Polymorphism 0.338 0.105 0.28 -24 0.192 P28799 A9D Disease NA 0.541 0.00 38 0.708 P28827 S39R Polymorphism NA 0.290 0.12 30 0.225 P28906 A367S Polymorphism 0.463 0.340 0.00 49 0.502 P28908 C273F Polymorphism 0.432 0.412 0.00 62 0.571 P28908 S402G Polymorphism 0.117 0.150 0.06 -27 0.031 P29017 N70T Polymorphism NA 0.241 0.32 -32 0.108 P29033 D50N Disease 0.471 0.828 0.21 -40 0.515 P29033 D50Y Disease 0.796 0.864 0.02 16 0.847 P29033 D66H Disease 0.998 0.936 0.00 68 0.953 P29033 F83L Polymorphism 0.073 0.695 0.51 -21 0.245 P29033 G12R Disease 0.935 0.881 0.07 -22 0.865 P29033 G59A Disease 0.996 0.837 0.01 42 0.920 P29033 G59S Disease 0.997 0.781 0.01 38 0.904 P29033 L79P Disease 0.964 0.973 0.00 48 0.934 P29033 L90P Disease 0.867 0.945 0.00 38 0.851 P29033 M93I Disease 0.447 0.543 0.31 -27 0.445 P29033 N54K Disease 0.915 0.924 0.00 44 0.902 P29033 Q80K Disease 0.991 0.931 0.00 54 0.950 P29033 R32H Disease 0.998 0.919 0.00 70 0.957 P29033 R75Q Disease 0.658 0.915 0.01 55 0.908 P29033 R75W Disease 0.933 0.950 0.00 56 0.943 P29033 S17F Disease 0.997 0.932 0.00 54 0.952 P29033 V27I Polymorphism 0.087 0.493 0.08 1 0.193 P29033 V37I Disease 0.294 0.337 0.07 -36 0.368 P29033 V84L Disease 0.405 0.902 0.00 21 0.638 P29033 V95M Disease 0.564 0.726 0.04 26 0.643 P29033 W44C Disease 0.997 0.893 0.00 49 0.942 P29033 W44S Disease 0.997 0.788 0.00 46 0.905 P29033 W77R Disease 0.998 0.950 0.00 59 0.957 P29033 A197S Disease 0.081 0.380 0.79 -33 0.208 P29033 C169Y Polymorphism 0.999 0.973 0.00 73 0.957 P29033 C202F Disease 0.943 0.954 0.02 38 0.899 P29033 D159V Disease NA 0.448 0.07 23 0.456 P29033 D179N Disease 0.889 0.930 0.10 19 0.864 P29033 E129K Disease 0.406 0.692 0.54 -57 0.339 P29033 F191L Polymorphism 0.992 0.917 0.00 11 0.966 P29033 G160S Polymorphism 0.698 0.871 0.01 40 0.796 P29033 I203K Disease 0.552 0.836 0.00 39 0.870 P29033 I203T Polymorphism 0.404 0.660 0.00 14 0.678 P29033 L214P Disease 0.637 0.827 0.02 29 0.771 P29033 R127H Polymorphism 0.657 0.542 0.58 -54 0.683 P29033 R143Q Disease 0.658 0.902 0.01 44 0.875 P29033 R143W Disease 0.933 0.944 0.00 44 0.904 P29033 R184P Disease 0.808 0.937 0.00 40 0.882 P29033 R184Q Disease 0.640 0.862 0.01 41 0.866 P29033 R184W Disease 0.928 0.920 0.00 46 0.912 P29033 S113R Disease 0.215 0.424 0.57 -42 0.211 P29033 T123N Polymorphism 0.218 0.355 0.56 -70 0.177 P29033 V178A Disease 0.832 0.914 0.00 47 0.898 P29084 I133T Polymorphism 0.092 0.124 0.37 -12 0.051 P29084 K183R Polymorphism 0.308 0.195 0.14 -34 0.215 P29120 G483R Disease 0.562 0.567 0.52 27 0.473 P29120 N221D Polymorphism 0.273 0.723 0.10 25 0.510 P29120 S307L Disease 0.942 0.853 0.00 46 0.907 P29120 S690T Polymorphism NA 0.067 0.13 22 0.026 P29122 C502R Polymorphism 0.788 0.879 0.00 74 0.937 P29218 I109V Polymorphism 0.331 0.297 0.15 -16 0.295 P29274 G392R Polymorphism NA 0.171 0.44 36 0.150 P29317 K99N Polymorphism 0.226 0.839 0.03 27 0.653 P29317 G391R Polymorphism 0.308 0.828 0.00 30 0.632 P29317 M631T Polymorphism 0.109 0.485 0.32 -3 0.045 P29317 R568H Polymorphism 0.646 0.500 0.10 -1 0.676 P29317 R876H Polymorphism 0.476 0.853 0.05 7 0.723 P29317 T511M Polymorphism 0.850 0.677 0.00 58 0.921 P29320 A777G Polymorphism NA 0.262 0.32 0 0.284 P29320 C568S Polymorphism 0.152 0.607 0.60 -1 0.239 P29320 I564V Polymorphism 0.102 0.204 0.57 -28 0.208 P29320 L590P Polymorphism 0.115 0.772 0.21 26 0.246 P29320 R914H Polymorphism 0.189 0.350 0.15 3 0.323 P29320 W924R Polymorphism 0.530 0.474 0.40 32 0.217 P29322 G45S Polymorphism 0.440 0.701 0.02 -1 0.619 P29322 V60L Polymorphism 0.130 0.251 0.69 5 0.256 P29322 E612Q Polymorphism 0.220 0.263 0.00 22 0.295 P29322 V444M Polymorphism 0.087 0.204 0.14 -27 0.202 P29323 A279S Disease 0.216 0.354 0.33 -20 0.284 P29323 C289G Polymorphism 0.948 0.967 0.00 44 0.919 P29323 D678N Polymorphism 0.306 0.790 0.22 -5 0.479 P29323 H679N Disease 0.971 0.960 0.06 60 0.966 P29323 I361V Polymorphism 0.223 0.114 0.80 -7 0.118 P29323 I909M Disease NA 0.272 0.19 15 0.223 P29323 M883V Disease 0.380 0.481 0.10 45 0.585 P29323 R199H Disease 0.339 0.500 0.40 1 0.426 P29323 R844W Polymorphism 0.988 0.869 0.01 41 0.940 P29323 V650A Disease 0.892 0.742 0.01 34 0.842 P29353 M410V Polymorphism 0.101 0.257 0.70 35 0.046 P29371 A449T Polymorphism NA 0.114 0.36 -19 0.022 P29372 K22Q Polymorphism NA 0.152 0.00 -4 0.056 P29372 P64L Polymorphism NA 0.106 0.00 1 0.159 P29374 H412P Polymorphism 0.076 0.401 0.21 26 0.201 P29375 M865T Polymorphism NA 0.095 0.74 -30 0.172 P29375 P1190A Polymorphism 0.095 0.129 0.72 0 0.125 P29376 R42Q Polymorphism NA 0.073 0.00 -11 0.105 P29376 C384R Polymorphism 0.032 0.882 0.00 71 0.802 P29376 P745S Polymorphism 0.893 0.834 0.01 33 0.841 P29376 P838S Polymorphism NA 0.116 0.20 -20 0.080 P29376 R673Q Polymorphism 0.232 0.341 0.09 -22 0.272 P29400 G54D Disease NA 0.718 NA 70 0.933 P29400 A430D Polymorphism NA 0.572 NA 59 0.521 P29400 E633K Disease NA 0.626 NA 37 0.496 P29400 G114S Disease 0.113 0.622 NA 51 0.523 P29400 G129E Disease 0.526 0.632 NA 68 0.889 P29400 G129V Disease 0.583 0.647 NA 61 0.867 P29400 G174R Disease NA 0.800 NA 65 0.955 P29400 G177C Disease NA 0.736 NA 53 0.885 P29400 G177R Disease NA 0.774 NA 55 0.907 P29400 G192R Disease NA 0.660 NA 67 0.898 P29400 G204V Disease NA 0.565 NA 52 0.775 P29400 G216R Disease NA 0.824 NA 65 0.977 P29400 G219S Disease NA 0.775 NA 45 0.715 P29400 G230R Disease NA 0.804 NA 59 0.934 P29400 G239E Disease NA 0.660 NA 49 0.776 P29400 G264R Disease NA 0.822 NA 55 0.951 P29400 G289V Disease NA 0.780 NA 58 0.917 P29400 G292R Disease NA 0.801 NA 70 0.961 P29400 G292V Disease NA 0.794 NA 60 0.932 P29400 G295D Disease NA 0.822 NA 68 0.983 P29400 G298S Disease NA 0.833 NA 61 0.971 P29400 G319R Disease NA 0.837 NA 68 0.984 P29400 G325E Disease NA 0.848 NA 72 0.982 P29400 G325R Disease NA 0.869 NA 74 0.982 P29400 G331V Disease NA 0.854 NA 54 0.954 P29400 G365E Disease NA 0.864 NA 62 0.976 P29400 G371E Disease NA 0.883 NA 57 0.964 P29400 G374A Disease NA 0.857 NA 26 0.853 P29400 G383D Disease NA 0.828 NA 38 0.854 P29400 G400E Disease NA 0.867 NA 70 0.984 P29400 G406V Disease NA 0.842 NA 63 0.982 P29400 G409D Disease NA 0.873 NA 71 0.984 P29400 G412V Disease NA 0.785 NA 57 0.913 P29400 G415R Disease NA 0.824 NA 73 0.976 P29400 G420E Disease NA 0.681 NA 23 0.766 P29400 G420V Disease NA 0.727 NA 20 0.768 P29400 G423E Disease NA 0.755 NA 6 0.739 P29400 G466E Disease NA 0.857 NA 44 0.869 P29400 G472R Disease NA 0.843 NA 60 0.970 P29400 G491E Disease NA 0.748 NA 53 0.884 P29400 G494D Disease NA 0.833 NA 40 0.857 P29400 G497C Disease NA 0.799 NA 48 0.860 P29400 G521C Disease NA 0.832 NA 75 0.984 P29400 G521S Disease NA 0.826 NA 76 0.913 P29400 G524D Disease NA 0.851 NA 80 0.984 P29400 G545R Disease NA 0.884 NA 59 0.969 P29400 G545V Disease NA 0.862 NA 54 0.953 P29400 G558R Disease NA 0.887 NA 69 0.983 P29400 G561R Disease NA 0.871 NA 58 0.967 P29400 G567A Disease NA 0.857 NA 52 0.776 P29400 G573D Disease NA 0.850 NA 75 0.984 P29400 G579E Disease NA 0.829 NA 64 0.982 P29400 G579R Disease NA 0.789 NA 69 0.964 P29400 G603V Disease NA 0.872 NA 52 0.941 P29400 G609R Disease NA 0.824 NA 79 0.984 P29400 G609V Disease NA 0.849 NA 68 0.984 P29400 G621C Disease NA 0.755 NA 59 0.913 P29400 G624D Disease NA 0.786 NA 4 0.577 P29400 G629D Disease NA 0.812 NA 58 0.957 P29400 G632D Disease NA 0.846 NA 71 0.983 P29400 G635D Disease NA 0.847 NA 66 0.982 P29400 G638A Disease NA 0.829 NA 53 0.937 P29400 G638S Disease NA 0.841 NA 57 0.806 P29400 G638V Disease NA 0.836 NA 58 0.964 P29400 G653R Disease NA 0.801 NA 58 0.918 P29400 G669A Disease NA 0.846 NA 17 0.686 P29400 G681D Disease NA 0.844 NA 70 0.984 P29400 G684V Disease NA 0.840 NA 48 0.891 P29400 G687E Disease NA 0.837 NA 76 0.984 P29400 G722E Disease NA 0.839 NA 69 0.984 P29400 G740E Disease NA 0.870 NA 65 0.983 P29400 G743D Disease NA 0.824 NA 57 0.958 P29400 G772D Disease NA 0.853 NA 83 0.983 P29400 G796R Disease NA 0.890 NA 76 0.984 P29400 G802R Disease NA 0.868 NA 81 0.984 P29400 G808E Disease NA 0.868 NA 79 0.983 P29400 G811V Disease NA 0.836 NA 63 0.981 P29400 G822R Disease NA 0.763 NA 71 0.959 P29400 G852E Disease NA 0.775 NA 53 0.754 P29400 G852R Disease NA 0.828 NA 59 0.960 P29400 G866E Disease NA 0.867 NA 72 0.984 P29400 G869R Disease NA 0.851 NA 71 0.984 P29400 G872R Disease NA 0.832 NA 61 0.971 P29400 G878R Disease NA 0.865 NA 62 0.976 P29400 G902V Disease NA 0.838 NA 65 0.983 P29400 G911E Disease NA 0.831 NA 68 0.983 P29400 G941C Disease NA 0.818 NA 60 0.965 P29400 G947D Disease NA 0.854 NA 72 0.984 P29400 G953V Disease NA 0.822 NA 47 0.753 P29400 K664N Polymorphism NA 0.250 NA 20 0.242 P29400 M898V Disease NA 0.562 NA 26 0.380 P29400 P619S Polymorphism NA 0.454 NA 13 0.395 P29400 P739S Disease NA 0.403 NA 1 0.365 P29400 A1498D Disease 0.669 0.638 NA 41 0.805 P29400 C1564S Disease NA 0.865 NA 61 0.805 P29400 C1567R Disease NA 0.863 NA 71 0.910 P29400 C1678W Disease NA 0.941 NA 54 0.918 P29400 G1006A Disease NA 0.560 NA 51 0.773 P29400 G1006V Disease NA 0.612 NA 56 0.783 P29400 G1015E Disease NA 0.830 NA 75 0.984 P29400 G1015V Disease NA 0.800 NA 67 0.964 P29400 G1030S Disease NA 0.850 NA 76 0.905 P29400 G1036V Disease NA 0.867 NA 71 0.984 P29400 G1039S Disease NA 0.845 NA 60 0.970 P29400 G1045E Disease NA 0.799 NA 75 0.964 P29400 G1066R Disease NA 0.845 NA 60 0.969 P29400 G1066S Disease NA 0.848 NA 49 0.775 P29400 G1086D Disease NA 0.848 NA 75 0.984 P29400 G1104V Disease 0.583 0.880 NA 61 0.970 P29400 G1107R Disease 0.997 0.897 NA 70 0.991 P29400 G1143D Disease 0.993 0.856 NA 64 0.991 P29400 G1143S Disease 0.990 0.854 NA 50 0.970 P29400 G1158R Disease 0.114 0.783 NA 77 0.762 P29400 G1161R Disease 0.410 0.837 NA 70 0.974 P29400 G1167S Disease 0.407 0.842 NA 57 0.946 P29400 G1170S Disease 0.407 0.847 NA 68 0.892 P29400 G1182R Disease 0.611 0.828 NA 62 0.971 P29400 G1196R Disease 0.611 0.831 NA 61 0.968 P29400 G1205C Disease 0.999 0.829 NA 57 0.989 P29400 G1211E Disease 0.646 0.730 NA 51 0.928 P29400 G1211R Disease 0.723 0.803 NA 57 0.945 P29400 G1220D Disease 0.514 0.849 NA 59 0.966 P29400 G1229D Disease 0.998 0.746 NA 72 0.990 P29400 G1241C Disease 0.999 0.733 NA 55 0.967 P29400 G1244D Disease 0.790 0.694 NA 66 0.826 P29400 G1252S Disease 0.685 0.700 NA 68 0.821 P29400 G1261E Disease 0.999 0.670 NA 71 0.968 P29400 G1270S Disease 0.998 0.702 NA 55 0.963 P29400 G1333S Disease 0.685 0.616 NA 47 0.857 P29400 G1357S Disease 0.078 0.618 NA 55 0.344 P29400 G1379V Disease 0.560 0.783 NA 58 0.908 P29400 G1421W Disease 0.917 0.774 NA 78 0.965 P29400 G1427V Disease 0.999 0.654 NA 59 0.948 P29400 G1442D Disease 0.643 0.672 NA 62 0.920 P29400 G1451S Disease 0.201 0.707 NA 51 0.738 P29400 G1486A Disease 0.575 0.570 NA 45 0.647 P29400 G1596D Disease 0.733 0.887 NA 64 0.881 P29400 L1649R Disease NA 0.914 NA 45 0.874 P29400 P1517T Disease 0.706 0.797 NA 23 0.825 P29400 R1410C Disease 0.417 0.447 NA 30 0.505 P29400 R1422C Disease 0.347 0.542 NA 8 0.581 P29400 R1511H Disease 0.226 0.266 NA 14 0.297 P29400 R1563Q Disease NA 0.789 NA 45 0.759 P29400 R1677P Disease NA 0.947 NA 48 0.879 P29400 R1677Q Disease NA 0.791 NA 46 0.699 P29400 S1488F Disease 0.763 0.706 NA 51 0.909 P29400 W1538S Disease 0.782 0.930 NA 53 0.881 P29474 E298D Polymorphism NA 0.210 0.07 -11 0.214 P29474 Q982L Polymorphism 0.394 0.636 0.22 -6 0.478 P29474 R112Q Polymorphism NA 0.126 0.51 41 0.263 P29474 R885M Polymorphism NA 0.238 0.16 12 0.249 P29474 V827M Polymorphism NA 0.100 0.05 -3 0.199 P29475 D394A Polymorphism NA 0.410 0.28 -27 0.237 P29475 P228S Polymorphism NA 0.132 0.00 9 0.155 P29475 Q1064R Polymorphism NA 0.194 0.11 39 0.352 P29590 F645L Polymorphism NA 0.174 NA 11 0.017 P29597 R4C Polymorphism NA 0.052 NA 2 0.033 P29597 R4H Polymorphism NA 0.065 NA 7 0.032 P29597 A81V Polymorphism 0.346 0.212 0.46 14 0.352 P29597 A928V Polymorphism 0.876 0.931 0.01 40 0.816 P29597 G363S Polymorphism 0.078 0.062 0.36 -50 0.064 P29597 I684S Polymorphism 0.718 0.433 0.10 52 0.693 P29597 P820H Polymorphism NA 0.247 0.21 44 0.414 P29597 R197H Polymorphism 0.298 0.237 0.07 0 0.124 P29597 R442Q Polymorphism 0.433 0.373 0.57 47 0.339 P29597 R703W Polymorphism 0.618 0.489 0.01 43 0.748 P29597 V362F Polymorphism 0.120 0.117 0.08 21 0.105 P29597 V386M Polymorphism 0.391 0.291 0.09 -13 0.272 P29597 E1163G Polymorphism 0.202 0.157 0.38 -3 0.235 P29597 P1104A Polymorphism NA 0.487 0.10 30 0.557 P29803 M280L Polymorphism 0.118 0.249 1.00 -34 0.142 P29965 G38R Disease 0.769 0.907 0.07 46 0.865 P29965 M36R Disease 0.358 0.652 0.06 43 0.677 P29965 A123E Disease 0.389 0.243 0.09 51 0.255 P29965 A173D Disease 0.379 0.411 0.00 46 0.311 P29965 A208D Disease 0.303 0.293 0.01 67 0.351 P29965 A235P Disease 0.471 0.425 0.03 21 0.241 P29965 G116R Disease 0.100 0.235 0.13 45 0.222 P29965 G116S Disease 0.288 0.178 0.22 36 0.156 P29965 G144E Disease 0.398 0.511 0.17 38 0.683 P29965 G219R Polymorphism 0.302 0.146 0.20 41 0.111 P29965 G226A Disease 0.980 0.387 0.09 60 0.749 P29965 G227V Disease 0.745 0.572 0.00 60 0.881 P29965 G257D Disease 0.997 0.561 0.00 73 0.943 P29965 G257S Disease 0.995 0.409 0.00 61 0.842 P29965 H125R Disease 0.340 0.314 0.01 54 0.441 P29965 H224Y Disease 0.460 0.110 1.00 44 0.093 P29965 K143T Disease 0.373 0.127 0.57 24 0.050 P29965 L155P Disease 0.665 0.387 0.01 48 0.349 P29965 L195P Disease 0.803 0.500 0.08 37 0.717 P29965 L231S Disease 0.989 0.520 0.00 57 0.918 P29965 L258S Disease 0.637 0.211 0.02 28 0.319 P29965 Q174R Disease 0.436 0.661 0.02 63 0.752 P29965 T147N Disease 0.420 0.397 0.06 35 0.261 P29965 T176I Disease 0.471 0.500 0.24 21 0.671 P29965 T211N Disease 0.196 0.215 0.81 59 0.198 P29965 T254M Disease 0.628 0.323 0.00 54 0.414 P29965 V126A Disease 0.435 0.118 0.02 -3 0.145 P29965 V126D Disease 0.760 0.231 0.11 53 0.279 P29965 V237E Disease 0.710 0.388 0.00 52 0.364 P29965 W140C Disease 0.878 0.695 0.00 70 0.924 P29965 W140G Disease 0.729 0.638 0.00 66 0.852 P29965 W140R Disease 0.763 0.755 0.00 73 0.897 P29965 Y170C Disease 0.850 0.814 0.00 55 0.932 P29966 P250L Polymorphism 0.292 0.142 0.26 10 0.062 P29972 A45V Polymorphism NA 0.280 0.45 6 0.351 P29973 R32Q Polymorphism NA 0.062 0.54 -12 0.062 P29973 N122D Polymorphism NA 0.102 0.61 43 0.149 P29973 S320F Disease 0.188 0.907 0.06 -2 0.399 P30038 P16L Polymorphism NA 0.182 0.06 30 0.181 P30038 S352L Disease 0.849 0.632 0.00 48 0.781 P30039 R17C Polymorphism 0.572 0.740 0.07 39 0.706 P30039 H257R Polymorphism 0.334 0.390 0.61 -1 0.159 P30042 V6A Polymorphism NA 0.171 0.00 -48 0.023 P30042 L248V Polymorphism NA 0.405 0.39 -2 0.283 P30043 R46Q Polymorphism 0.113 0.193 0.60 -1 0.155 P30048 A218T Polymorphism 0.623 0.900 0.00 48 0.823 P30048 R170Q Polymorphism 0.208 0.483 0.20 9 0.354 P30048 T234I Polymorphism 0.392 0.353 0.10 9 0.506 P30084 T75I Polymorphism 0.743 0.342 0.18 -36 0.511 P30084 V11A Polymorphism NA 0.097 0.53 -6 0.074 P30101 K415R Polymorphism 0.841 0.360 0.05 -1 0.601 P30203 A271T Polymorphism 0.190 0.346 0.23 -11 0.159 P30203 G606S Polymorphism 0.070 0.279 NA -21 0.179 P30203 R225W Polymorphism 0.880 0.368 0.02 23 0.384 P30260 S320P Polymorphism 0.303 0.117 0.54 -28 0.170 P30260 Y496H Polymorphism NA 0.447 0.51 -17 0.377 P30281 E253D Polymorphism 0.146 0.323 0.45 -7 0.217 P30281 S259A Polymorphism 0.191 0.107 0.33 7 0.136 P30291 S472I Polymorphism 0.572 0.383 0.12 16 0.605 P30304 R182G Polymorphism 0.183 0.103 0.37 1 0.081 P30304 R182W Polymorphism 0.579 0.037 0.04 23 0.091 P30305 E548K Polymorphism 0.116 0.431 0.60 19 0.234 P30307 S14N Polymorphism NA 0.089 0.33 23 0.075 P30307 S78N Polymorphism 0.178 0.171 0.00 0 0.291 P30414 L861V Polymorphism NA 0.138 0.53 11 0.103 P30414 S935L Polymorphism NA 0.134 0.16 14 0.077 P30419 Q61K Polymorphism NA 0.124 0.87 -21 0.096 P30443 F33S Polymorphism 0.304 0.538 0.30 28 0.361 P30443 D114A Polymorphism 0.200 0.241 0.80 -8 0.187 P30443 G131W Polymorphism 0.626 0.515 0.07 44 0.555 P30443 I121M Polymorphism 0.221 0.265 0.26 -30 0.154 P30443 N151K Polymorphism 0.576 0.956 0.03 43 0.771 P30443 R180L Polymorphism 0.182 0.622 0.79 7 0.195 P30443 V182A Polymorphism 0.530 0.069 1.00 -41 0.037 P30447 Y31C Polymorphism 0.943 0.936 0.00 66 0.944 P30447 K151N Polymorphism 0.576 0.207 1.00 -20 0.022 P30447 L180W Polymorphism 0.240 0.514 0.19 -32 0.293 P30447 R205H Polymorphism 0.767 0.852 0.03 33 0.808 P30450 F60L Polymorphism 0.498 0.746 0.00 50 0.744 P30450 H94Q Polymorphism 0.229 0.231 0.56 -10 0.175 P30450 E176V Polymorphism 0.244 0.189 0.51 -21 0.243 P30450 E185D Polymorphism 0.582 0.714 0.26 25 0.641 P30450 G131W Polymorphism 0.626 0.856 0.07 43 0.719 P30450 I166T Polymorphism 0.408 0.795 0.59 13 0.687 P30450 N101D Polymorphism 0.347 0.653 0.80 26 0.486 P30450 P129S Polymorphism 0.261 0.717 0.72 -29 0.447 P30450 R169H Polymorphism 0.507 0.888 0.13 1 0.606 P30450 R187L Polymorphism 0.188 0.473 0.50 2 0.182 P30453 I3V Polymorphism 0.177 0.107 1.00 -83 0.141 P30453 D101N Polymorphism 0.347 0.243 1.00 -32 0.235 P30453 L312I Polymorphism 0.318 0.243 1.00 -57 0.209 P30453 N151K Polymorphism 0.576 0.953 0.03 52 0.780 P30453 P129S Polymorphism 0.261 0.720 0.71 -31 0.447 P30453 Q138R Polymorphism 0.243 0.485 0.38 -22 0.211 P30453 R121I Polymorphism 0.474 0.724 0.45 40 0.584 P30455 R89G Polymorphism 0.477 0.813 0.06 7 0.590 P30455 I166T Polymorphism 0.408 0.819 0.38 15 0.694 P30455 R169H Polymorphism 0.507 0.889 0.15 -1 0.604 P30455 R205H Polymorphism 0.767 0.854 0.04 -8 0.806 P30455 V182A Polymorphism 0.530 0.064 1.00 -43 0.033 P30456 I166T Polymorphism 0.408 0.796 0.59 27 0.694 P30456 N151K Polymorphism 0.576 0.952 0.03 54 0.781 P30457 R89G Polymorphism 0.477 0.805 0.06 28 0.652 P30457 S28W Polymorphism 0.772 0.855 0.00 37 0.835 P30457 D101N Polymorphism 0.347 0.243 1.00 -37 0.235 P30457 R187E Polymorphism 0.378 0.126 1.00 -7 0.118 P30459 R23W Polymorphism 0.157 0.793 0.65 -45 0.309 P30459 T97A Polymorphism 0.412 0.338 0.22 -9 0.357 P30459 G103A Polymorphism 0.212 0.232 0.44 -26 0.279 P30459 N151K Polymorphism 0.576 0.952 0.03 43 0.766 P30460 M4T Polymorphism 0.121 0.874 0.29 31 0.224 P30460 V9L Polymorphism 0.206 0.255 1.00 -78 0.170 P30460 D98Y Polymorphism 0.197 0.482 0.94 0 0.299 P30460 N87D Polymorphism 0.328 0.425 0.20 33 0.577 P30460 A329T Polymorphism 0.280 0.302 0.64 -51 0.335 P30460 H137Y Polymorphism 0.504 0.166 1.00 1 0.101 P30460 R155S Polymorphism 0.255 0.763 0.76 0 0.501 P30460 V176E Polymorphism 0.244 0.302 0.64 -6 0.321 P30460 Y140D Polymorphism 0.371 0.906 0.21 56 0.771 P30461 A329T Polymorphism 0.280 0.287 0.65 -20 0.330 P30461 E187L Polymorphism 0.399 0.464 0.52 25 0.417 P30461 L140S Polymorphism 0.371 0.493 0.16 26 0.390 P30461 L169R Polymorphism 0.541 0.129 1.00 -29 0.041 P30461 N138D Polymorphism 0.304 0.289 0.23 -13 0.220 P30461 T121R Polymorphism 0.394 0.252 0.57 2 0.215 P30461 V306I Polymorphism 0.201 0.069 1.00 -27 0.038 P30461 Y183C Polymorphism 0.977 0.904 0.01 61 0.950 P30462 M4T Polymorphism 0.121 0.875 0.29 17 0.229 P30462 V9L Polymorphism 0.206 0.259 1.00 -78 0.170 P30462 N87D Polymorphism 0.328 0.398 0.19 33 0.575 P30462 N87K Polymorphism 0.266 0.652 0.19 37 0.697 P30464 A48S Polymorphism 0.311 0.274 0.34 -18 0.332 P30464 E87N Polymorphism 0.416 0.546 0.32 12 0.476 P30464 S91Y Polymorphism 0.250 0.354 1.00 -26 0.227 P30464 R121T Polymorphism 0.394 0.836 0.56 37 0.705 P30464 W180L Polymorphism 0.240 0.294 0.82 17 0.240 P30466 Y98D Polymorphism 0.197 0.669 0.59 25 0.385 P30466 H195Y Polymorphism 0.709 0.103 1.00 -4 0.190 P30466 T187E Polymorphism 0.205 0.219 1.00 0 0.269 P30475 C91Y Polymorphism 0.405 0.317 1.00 -16 0.043 P30475 L17V Polymorphism 0.352 0.813 0.35 -60 0.619 P30475 N87D Polymorphism 0.328 0.398 0.24 32 0.574 P30475 N87E Polymorphism 0.416 0.144 1.00 7 0.143 P30475 N87K Polymorphism 0.266 0.652 0.08 37 0.703 P30475 S35A Polymorphism 0.507 0.064 1.00 -27 0.052 P30475 T97A Polymorphism 0.412 0.254 0.22 -17 0.350 P30475 A329T Polymorphism 0.280 0.286 0.63 -51 0.329 P30475 F140S Polymorphism 0.377 0.530 0.16 46 0.547 P30475 L180R Polymorphism 0.182 0.506 0.50 3 0.170 P30475 M122T Polymorphism 0.517 0.961 0.02 37 0.756 P30475 N138D Polymorphism 0.304 0.274 0.23 -25 0.220 P30475 Q168R Polymorphism 0.251 0.458 0.36 -3 0.365 P30475 R121T Polymorphism 0.394 0.833 0.61 39 0.713 P30475 V306I Polymorphism 0.201 0.069 1.00 -38 0.037 P30475 Y123S Polymorphism 0.456 0.915 0.19 37 0.722 P30479 V9L Polymorphism 0.206 0.219 1.00 -77 0.162 P30479 A329T Polymorphism 0.280 0.301 0.63 -17 0.337 P30479 N104K Polymorphism 0.238 0.654 0.12 5 0.459 P30479 N138D Polymorphism 0.304 0.284 0.24 -15 0.220 P30479 R121S Polymorphism 0.359 0.709 0.68 37 0.530 P30479 V127L Polymorphism 0.305 0.627 0.45 21 0.474 P30480 M4T Polymorphism 0.121 0.874 0.29 29 0.223 P30480 A65T Polymorphism 0.254 0.319 0.08 -22 0.353 P30480 L17V Polymorphism 0.352 0.813 0.35 -53 0.621 P30480 N87D Polymorphism 0.328 0.128 0.20 34 0.329 P30480 V36M Polymorphism 0.403 0.626 0.23 14 0.491 P30480 Y33H Polymorphism 0.384 0.879 0.30 30 0.678 P30480 S101N Polymorphism 0.295 0.144 1.00 -26 0.142 P30480 V306I Polymorphism 0.201 0.070 1.00 -31 0.038 P30481 D140Y Polymorphism 0.371 0.381 1.00 10 0.305 P30481 D180L Polymorphism 0.286 0.396 0.79 1 0.224 P30481 L187T Polymorphism 0.350 0.149 0.65 -32 0.126 P30481 V306I Polymorphism 0.201 0.067 1.00 -24 0.037 P30483 L17V Polymorphism 0.352 0.813 0.36 -51 0.621 P30483 Q139R Polymorphism 0.518 0.914 0.47 33 0.695 P30484 D98G Polymorphism 0.493 0.524 0.41 10 0.570 P30485 A329T Polymorphism 0.280 0.274 0.66 -64 0.327 P30485 D101S Polymorphism 0.216 0.083 0.52 0 0.150 P30485 T104N Polymorphism 0.311 0.435 0.34 -12 0.352 P30486 V9L Polymorphism 0.206 0.250 1.00 -80 0.170 P30486 L17V Polymorphism 0.352 0.816 0.35 -51 0.621 P30486 S35A Polymorphism 0.507 0.131 1.00 -23 0.143 P30486 A329T Polymorphism 0.280 0.292 0.65 -50 0.331 P30486 E187A Polymorphism 0.367 0.362 0.75 27 0.388 P30486 E187K Polymorphism 0.331 0.525 0.79 28 0.491 P30486 S121R Polymorphism 0.359 0.539 0.50 10 0.357 P30486 V306I Polymorphism 0.201 0.069 1.00 -19 0.039 P30486 Y195H Polymorphism 0.709 0.815 0.08 40 0.743 P30487 V9L Polymorphism 0.206 0.220 1.00 -79 0.162 P30487 K69T Polymorphism 0.251 0.254 0.44 -13 0.211 P30487 L17V Polymorphism 0.352 0.814 0.33 -55 0.619 P30487 L56Q Polymorphism 0.514 0.203 1.00 -38 0.021 P30487 T65A Polymorphism 0.254 0.057 1.00 -28 0.025 P30487 I104T Polymorphism 0.315 0.075 1.00 -29 0.084 P30488 V9L Polymorphism 0.206 0.217 1.00 -80 0.157 P30488 L127V Polymorphism 0.305 0.267 1.00 -28 0.321 P30488 W191S Polymorphism 0.402 0.786 0.34 46 0.732 P30490 E176V Polymorphism 0.244 0.204 0.51 -16 0.264 P30491 N101D Polymorphism 0.347 0.470 0.79 12 0.430 P30491 V176E Polymorphism 0.244 0.371 0.42 9 0.354 P30491 Y195H Polymorphism 0.709 0.850 0.06 43 0.748 P30492 D98Y Polymorphism 0.197 0.519 0.93 1 0.342 P30492 N87D Polymorphism 0.328 0.401 0.20 30 0.571 P30492 Y33H Polymorphism 0.384 0.901 0.29 38 0.716 P30493 E82A Polymorphism 0.665 0.803 0.00 28 0.857 P30493 T97A Polymorphism 0.412 0.224 0.20 -11 0.338 P30493 S155R Polymorphism 0.255 0.413 0.73 -14 0.208 P30493 T121S Polymorphism 0.237 0.280 0.62 -6 0.202 P30493 W119L Polymorphism 0.816 0.431 1.00 -5 0.043 P30495 D98Y Polymorphism 0.197 0.518 0.94 0 0.343 P30495 N87K Polymorphism 0.266 0.670 0.18 36 0.696 P30495 T97A Polymorphism 0.412 0.224 0.20 -10 0.334 P30495 L140Y Polymorphism 0.262 0.317 1.00 -17 0.213 P30495 L180W Polymorphism 0.240 0.537 0.19 -29 0.294 P30495 Y195H Polymorphism 0.709 0.864 0.06 41 0.745 P30498 F91C Polymorphism 0.375 0.183 0.18 -17 0.221 P30499 E43K Polymorphism 0.440 0.764 0.11 16 0.623 P30499 K90N Polymorphism 0.213 0.323 0.47 -27 0.199 P30499 N92K Polymorphism 0.638 0.119 1.00 -31 0.053 P30499 V76M Polymorphism 0.313 0.155 0.50 -42 0.163 P30499 E179Q Polymorphism 0.391 0.097 1.00 -57 0.135 P30499 M272V Polymorphism 0.800 0.116 0.76 -23 0.065 P30499 S364C Polymorphism NA 0.360 1.00 -32 0.238 P30499 Y140S Polymorphism 0.439 0.769 0.17 47 0.713 P30501 I10L Polymorphism 0.300 0.196 1.00 -82 0.052 P30501 E179Q Polymorphism 0.391 0.103 1.00 -50 0.117 P30501 S364C Polymorphism NA 0.359 1.00 -14 0.239 P30504 E73A Polymorphism 0.554 0.053 1.00 -28 0.021 P30504 G40S Polymorphism 0.549 0.890 0.11 14 0.678 P30504 R45H Polymorphism 0.613 0.918 0.12 1 0.674 P30504 S33Y Polymorphism 0.320 0.410 1.00 -19 0.285 P30504 W38R Polymorphism 0.581 0.194 1.00 17 0.032 P30504 A182V Polymorphism 0.530 0.506 0.02 6 0.534 P30505 A73E Polymorphism 0.554 0.529 0.07 14 0.612 P30505 V76M Polymorphism 0.313 0.146 0.51 18 0.191 P30505 L180R Polymorphism 0.182 0.520 0.43 10 0.162 P30505 T162K Polymorphism 0.297 0.696 0.44 -17 0.423 P30505 T176E Polymorphism 0.276 0.162 0.31 -29 0.145 P30505 V272M Polymorphism 0.800 0.437 0.07 -39 0.575 P30508 A73E Polymorphism 0.554 0.586 0.07 18 0.615 P30508 K90N Polymorphism 0.213 0.295 0.47 -27 0.199 P30508 V76M Polymorphism 0.313 0.158 0.50 -46 0.169 P30508 A182V Polymorphism 0.530 0.542 0.04 3 0.524 P30508 G144V Polymorphism 0.927 0.873 0.01 42 0.887 P30508 N104K Polymorphism 0.238 0.783 0.21 4 0.516 P30508 R121W Polymorphism 0.227 0.790 0.20 15 0.492 P30508 V272M Polymorphism 0.800 0.167 0.06 31 0.370 P30508 Y137H Polymorphism 0.504 0.933 0.14 38 0.750 P30510 A73E Polymorphism 0.554 0.579 0.07 31 0.624 P30510 K90N Polymorphism 0.213 0.271 0.48 -28 0.198 P30510 R45H Polymorphism 0.613 0.911 0.12 1 0.673 P30510 V76M Polymorphism 0.313 0.077 0.51 -46 0.134 P30510 A182V Polymorphism 0.530 0.500 0.02 8 0.536 P30510 S101N Polymorphism 0.295 0.059 1.00 -31 0.047 P30510 V272M Polymorphism 0.800 0.424 0.05 32 0.619 P30510 Y137H Polymorphism 0.504 0.934 0.13 38 0.742 P30511 A13V Polymorphism 0.309 0.572 0.07 -57 0.464 P30512 N90H Polymorphism 0.605 0.446 0.57 2 0.617 P30512 F133L Polymorphism 0.259 0.251 0.82 -29 0.299 P30512 I166T Polymorphism 0.408 0.756 0.72 30 0.662 P30512 S129P Polymorphism 0.261 0.604 0.90 -43 0.407 P30518 T7S Polymorphism NA 0.099 0.67 -9 0.073 P30518 A61V Polymorphism 0.087 0.714 0.04 -23 0.170 P30518 A84D Disease 0.587 0.922 0.01 57 0.911 P30518 D85N Disease 0.868 0.855 0.00 64 0.845 P30518 G12E Polymorphism NA 0.175 0.69 12 0.218 P30518 H80R Disease 0.924 0.891 0.00 60 0.943 P30518 I46K Disease 0.294 0.838 0.05 51 0.879 P30518 L43P Disease 0.688 0.846 0.00 43 0.837 P30518 L44P Disease 0.957 0.829 0.00 55 0.919 P30518 L53R Disease 0.607 0.839 0.16 54 0.886 P30518 L59P Disease 0.730 0.913 0.00 31 0.870 P30518 L62P Disease 0.771 0.913 0.00 32 0.868 P30518 L81F Disease 0.829 0.923 0.00 60 0.947 P30518 L83P Disease 0.730 0.848 0.01 37 0.827 P30518 L83Q Disease 0.662 0.778 0.01 15 0.826 P30518 L94Q Disease 0.718 0.824 0.00 35 0.849 P30518 N55D Disease 0.989 0.851 0.00 69 0.949 P30518 N55H Disease 0.996 0.841 0.00 65 0.950 P30518 P95L Disease 0.677 0.880 0.00 7 0.724 P30518 Q92R Disease 0.382 0.703 0.02 44 0.765 P30518 R64W Polymorphism 0.874 0.920 0.02 61 0.931 P30518 V88M Disease 0.886 0.594 0.00 8 0.840 P30518 W99R Disease 0.960 0.904 0.00 74 0.945 P30518 A132D Disease 0.490 0.888 0.03 54 0.897 P30518 A163P Disease 0.464 0.845 0.29 40 0.782 P30518 A294P Disease 0.461 0.738 0.01 40 0.806 P30518 C112R Disease 0.996 0.954 0.00 73 0.948 P30518 C112Y Disease 0.998 0.941 0.00 66 0.952 P30518 C319R Disease 0.955 0.922 0.00 65 0.940 P30518 D191G Disease 0.366 0.807 0.02 61 0.862 P30518 F105V Disease 0.901 0.847 0.00 59 0.917 P30518 F214S Disease 0.644 0.857 0.00 33 0.864 P30518 F287L Disease 0.808 0.860 0.00 25 0.743 P30518 G107E Disease 0.950 0.851 0.00 68 0.919 P30518 G122R Disease 0.725 0.926 0.01 56 0.916 P30518 G185C Disease 0.485 0.851 0.04 7 0.701 P30518 G201D Disease 0.950 0.776 0.02 37 0.850 P30518 I130F Disease 0.497 0.887 0.01 34 0.863 P30518 I209F Disease 0.519 0.829 0.22 -10 0.473 P30518 L135P Disease 0.688 0.837 0.02 54 0.905 P30518 L219P Disease 0.574 0.852 0.02 33 0.837 P30518 L219R Disease 0.446 0.892 0.01 13 0.795 P30518 L282P Disease 0.787 0.797 0.01 51 0.904 P30518 L289P Disease 0.748 0.809 0.02 41 0.778 P30518 L292P Disease 0.787 0.835 0.00 46 0.869 P30518 L309P Disease 0.718 0.790 0.00 48 0.835 P30518 L309R Disease 0.646 0.767 0.00 49 0.883 P30518 M123K Disease 0.929 0.939 0.00 66 0.937 P30518 M272K Disease 0.932 0.906 0.00 61 0.936 P30518 N317K Disease 0.424 0.899 0.01 65 0.912 P30518 N321D Disease 0.820 0.726 0.00 43 0.797 P30518 N321K Disease 0.880 0.845 0.00 66 0.921 P30518 N321Y Disease 0.946 0.817 0.00 58 0.920 P30518 P173S Disease 0.995 0.783 0.00 41 0.878 P30518 P217T Disease 0.996 0.876 0.00 51 0.944 P30518 P286L Disease 0.996 0.857 0.00 40 0.915 P30518 P286R Disease 0.996 0.885 0.00 59 0.952 P30518 P286S Disease 0.995 0.798 0.00 35 0.923 P30518 P322H Disease 0.997 0.782 0.00 65 0.945 P30518 P322S Disease 0.995 0.695 0.00 41 0.903 P30518 Q174L Disease 0.991 0.774 0.00 28 0.902 P30518 R104C Disease 0.587 0.867 0.00 62 0.907 P30518 R106C Disease 0.499 0.850 0.12 53 0.880 P30518 R113W Disease 0.874 0.948 0.00 61 0.936 P30518 R137C Disease 0.997 0.898 0.00 67 0.952 P30518 R137H Disease 0.996 0.894 0.00 68 0.949 P30518 R137L Disease 0.995 0.893 0.00 63 0.949 P30518 R139S Polymorphism 0.295 0.702 0.03 40 0.420 P30518 R143P Disease 0.487 0.889 0.03 55 0.900 P30518 R181C Disease 0.764 0.848 0.09 46 0.810 P30518 R202C Disease 0.331 0.848 0.15 6 0.603 P30518 R203C Disease 0.845 0.878 0.00 54 0.928 P30518 S126F Disease 0.949 0.924 0.00 55 0.936 P30518 S127F Disease 0.585 0.875 0.00 36 0.852 P30518 S167L Disease 0.549 0.891 0.04 -18 0.816 P30518 S167T Disease 0.381 0.876 0.10 11 0.528 P30518 S315R Disease 0.317 0.773 0.00 38 0.674 P30518 S318T Polymorphism 0.785 0.839 0.00 15 0.738 P30518 T204N Disease 0.219 0.701 0.01 33 0.492 P30518 T207N Disease 0.913 0.755 0.00 51 0.902 P30518 V206D Disease 0.739 0.865 0.00 59 0.733 P30518 V215M Polymorphism 0.358 0.668 0.01 20 0.629 P30518 V277A Disease 0.812 0.817 0.00 40 0.771 P30518 W164S Disease 0.963 0.837 0.00 58 0.931 P30518 W323R Disease 0.702 0.705 0.00 50 0.892 P30518 W323S Disease 0.691 0.556 0.00 38 0.787 P30518 Y128S Disease 0.931 0.845 0.00 45 0.894 P30518 Y205C Disease 0.972 0.941 0.00 66 0.941 P30519 P146L Polymorphism 0.840 0.916 0.01 38 0.905 P30520 L179F Polymorphism 0.548 0.843 0.02 12 0.642 P30530 S515G Polymorphism 0.628 0.438 0.32 22 0.569 P30530 T112M Polymorphism 0.329 0.142 0.00 10 0.108 P30531 P521Q Polymorphism 0.197 0.698 0.16 11 0.409 P30533 N114S Polymorphism 0.161 0.179 NA -7 0.120 P30533 V311M Polymorphism 0.160 0.066 NA -36 0.059 P30542 A43S Polymorphism 0.213 0.386 0.04 19 0.338 P30542 S50P Polymorphism 0.906 0.900 0.00 57 0.931 P30542 P261Q Polymorphism 0.274 0.415 0.32 14 0.360 P30556 L48V Polymorphism 0.273 0.601 0.30 -10 0.393 P30556 C289W Polymorphism 0.403 0.731 0.00 40 0.763 P30556 T282M Disease 0.680 0.453 0.22 -33 0.488 P30556 T336P Polymorphism 0.384 0.522 0.02 25 0.529 P30559 A218T Polymorphism 0.098 0.301 0.60 -2 0.162 P30566 A2V Disease NA 0.186 0.00 -53 0.218 P30566 A3V Disease NA 0.134 0.00 -6 0.048 P30566 I72V Disease 0.281 0.500 1.00 -5 0.350 P30566 M26L Disease 0.280 0.949 0.29 22 0.509 P30566 D268N Disease 0.777 0.816 0.22 53 0.796 P30566 D422Y Disease 0.666 0.757 0.10 50 0.891 P30566 D430N Disease 0.324 0.668 0.26 39 0.577 P30566 K147M Polymorphism 0.517 0.232 0.19 -72 0.480 P30566 K246E Disease 0.436 0.715 0.66 42 0.560 P30566 L311V Disease 0.270 0.581 0.32 -8 0.393 P30566 L423V Disease 0.423 0.806 0.23 52 0.711 P30566 P100A Disease 0.453 0.553 0.89 23 0.558 P30566 P318L Disease 0.337 0.799 0.08 11 0.603 P30566 R141W Disease 0.912 0.757 0.03 27 0.775 P30566 R190Q Disease 0.399 0.792 0.05 21 0.543 P30566 R194C Disease 0.914 0.832 0.16 17 0.783 P30566 R303C Disease 0.932 0.881 0.00 50 0.923 P30566 R374W Disease 0.871 0.709 0.02 24 0.825 P30566 R396C Disease 0.969 0.946 0.00 60 0.947 P30566 R396H Disease 0.898 0.916 0.00 57 0.934 P30566 R426H Disease 0.666 0.545 0.16 12 0.745 P30566 R452P Disease 0.614 0.823 0.13 50 0.896 P30566 S395R Disease 0.411 0.837 0.06 33 0.692 P30566 S438P Disease NA 0.545 0.12 15 0.459 P30566 S447P Disease 0.610 0.530 0.29 8 0.729 P30566 T450S Disease 0.755 0.344 0.04 50 0.651 P30566 V364M Disease 0.856 0.877 0.04 44 0.890 P30566 Y114H Disease 0.757 0.820 0.13 57 0.905 P30613 G37E Disease NA 0.168 0.34 36 0.158 P30613 G95R Disease 0.967 0.789 0.00 65 0.917 P30613 I90N Disease 0.981 0.875 0.00 49 0.914 P30613 L73P Disease NA 0.858 0.04 52 0.875 P30613 R40W Disease NA 0.225 0.00 46 0.162 P30613 R86P Disease NA 0.920 0.03 60 0.913 P30613 S80P Disease NA 0.764 0.24 13 0.759 P30613 A115P Disease 0.915 0.961 0.06 19 0.871 P30613 A154T Disease 0.713 0.313 0.08 -7 0.593 P30613 A295V Disease 0.249 0.222 0.36 -47 0.143 P30613 A336S Disease 0.641 0.768 0.00 15 0.658 P30613 A352D Disease 0.580 0.811 0.01 38 0.807 P30613 A392T Disease 0.861 0.861 0.01 13 0.793 P30613 A394D Disease 0.708 0.932 0.00 54 0.832 P30613 A394V Disease 0.953 0.879 0.00 40 0.864 P30613 A431T Disease 0.291 0.203 0.31 -39 0.248 P30613 A459V Disease 0.397 0.603 0.37 11 0.399 P30613 A468G Disease 0.759 0.661 0.05 33 0.717 P30613 A468V Disease 0.523 0.718 0.22 -6 0.445 P30613 A495T Disease 0.648 0.446 0.12 16 0.527 P30613 A495V Disease 0.562 0.500 0.10 18 0.428 P30613 D281N Disease 0.608 0.789 0.17 43 0.518 P30613 D293N Disease 0.673 0.796 0.01 10 0.643 P30613 D331E Disease 0.827 0.894 0.00 47 0.816 P30613 D331N Disease 0.890 0.877 0.05 48 0.752 P30613 D339H Disease 0.958 0.923 0.00 74 0.882 P30613 D390N Disease 0.951 0.884 0.01 61 0.879 P30613 E172Q Disease NA 0.151 0.10 -33 0.215 P30613 E315K Disease 0.939 0.953 0.00 60 0.884 P30613 E387G Disease 0.889 0.789 0.00 49 0.830 P30613 E427A Disease 0.564 0.225 0.43 1 0.527 P30613 E427D Disease 0.686 0.350 0.36 7 0.550 P30613 F287V Disease 0.789 0.751 0.00 58 0.865 P30613 G111R Disease 0.990 0.904 0.00 70 0.926 P30613 G159V Disease 0.955 0.934 0.00 49 0.910 P30613 G165V Disease 0.878 0.910 0.06 33 0.850 P30613 G222A Disease 0.940 0.814 0.00 48 0.824 P30613 G263R Disease 0.281 0.814 0.00 29 0.560 P30613 G263W Disease 0.853 0.758 0.00 26 0.824 P30613 G275R Disease 0.961 0.805 0.00 50 0.878 P30613 G332S Disease 0.833 0.878 0.03 31 0.761 P30613 G341A Disease 0.573 0.840 0.00 30 0.674 P30613 G341D Disease 0.973 0.943 0.00 59 0.886 P30613 G358E Disease 0.321 0.609 0.66 -37 0.172 P30613 G364D Disease 0.761 0.878 0.00 45 0.845 P30613 G458D Disease 0.534 0.591 0.04 46 0.574 P30613 G511R Disease 0.872 0.799 0.00 71 0.780 P30613 G557A Disease 0.525 0.749 0.12 43 0.609 P30613 I153T Disease 0.916 0.560 0.00 18 0.825 P30613 I219T Disease 0.797 0.192 0.01 29 0.516 P30613 I310N Disease 0.981 0.878 0.00 43 0.868 P30613 I314T Disease 0.924 0.807 0.00 52 0.873 P30613 I342F Disease 0.777 0.685 0.00 24 0.761 P30613 I357T Disease 0.878 0.807 0.00 15 0.799 P30613 K348N Disease 0.594 0.439 0.11 -50 0.517 P30613 L155P Disease 0.907 0.901 0.00 43 0.875 P30613 L272V Disease 0.787 0.597 0.01 4 0.606 P30613 L374P Disease 0.987 0.870 0.00 58 0.910 P30613 M107T Disease 0.647 0.751 0.00 35 0.825 P30613 N361D Disease 0.741 0.870 0.01 25 0.812 P30613 N393K Disease 0.712 0.738 0.03 47 0.825 P30613 N393S Disease 0.749 0.784 0.00 32 0.822 P30613 N566K Disease 0.578 0.790 0.00 70 0.878 P30613 Q421K Disease 0.604 0.784 0.01 31 0.794 P30613 R163C Disease 0.983 0.938 0.00 65 0.927 P30613 R163L Disease 0.919 0.951 0.00 58 0.921 P30613 R337P Disease 0.975 0.941 0.00 56 0.902 P30613 R337Q Disease 0.930 0.885 0.00 60 0.881 P30613 R359C Disease 0.865 0.557 0.00 30 0.799 P30613 R359H Disease 0.672 0.408 0.01 19 0.619 P30613 R385W Disease 0.990 0.936 0.00 60 0.865 P30613 R426Q Disease 0.318 0.403 0.49 -42 0.270 P30613 R426W Disease 0.915 0.787 0.19 -18 0.764 P30613 R479H Disease 0.553 0.244 0.23 -10 0.486 P30613 R486W Disease 0.944 0.929 0.00 33 0.824 P30613 R488Q Disease 0.837 0.881 0.01 59 0.815 P30613 R490W Disease 0.928 0.798 0.02 23 0.776 P30613 R498C Disease 0.906 0.679 0.11 26 0.784 P30613 R498H Disease 0.471 0.402 0.22 -22 0.306 P30613 R504L Disease 0.773 0.876 0.00 53 0.753 P30613 R510Q Disease 0.642 0.685 0.26 49 0.763 P30613 R531C Disease 0.856 0.700 0.05 14 0.820 P30613 R532Q Disease 0.673 0.120 0.04 10 0.356 P30613 R532W Disease 0.880 0.452 0.03 14 0.668 P30613 R559G Disease 0.517 0.456 0.29 26 0.563 P30613 R569Q Disease 0.363 0.644 0.07 38 0.543 P30613 S120F Disease 0.700 0.953 0.00 61 0.926 P30613 S130Y Disease 0.456 0.505 0.05 -16 0.428 P30613 S376I Disease 0.922 0.779 0.00 52 0.875 P30613 S485F Disease 0.975 0.839 0.00 52 0.841 P30613 T384M Disease 0.983 0.869 0.00 46 0.828 P30613 T408A Disease 0.789 0.688 0.00 44 0.774 P30613 T408I Disease 0.943 0.870 0.00 41 0.870 P30613 T477A Disease 0.589 0.300 0.04 42 0.615 P30613 V134D Disease 0.965 0.869 0.00 40 0.871 P30613 V288L Disease 0.717 0.604 0.02 44 0.803 P30613 V320L Disease 0.343 0.555 0.26 -30 0.204 P30613 V335M Disease 0.898 0.914 0.00 35 0.870 P30613 V368F Disease 0.893 0.842 0.00 1 0.869 P30613 V460M Disease 0.684 0.492 0.01 17 0.672 P30613 V506I Polymorphism 0.467 0.112 0.47 -25 0.195 P30613 V552M Disease 0.742 0.500 0.00 25 0.730 P30622 R780W Polymorphism 0.710 0.083 0.01 30 0.224 P30622 D1080E Polymorphism 0.099 0.055 0.81 -33 0.069 P30685 A48S Polymorphism 0.311 0.283 0.34 -21 0.334 P30685 N87E Polymorphism 0.416 0.153 1.00 6 0.146 P30685 T69E Polymorphism 0.208 0.329 0.42 -23 0.110 P30685 D138N Polymorphism 0.304 0.483 0.32 16 0.306 P30685 L133F Polymorphism 0.259 0.754 0.35 -26 0.482 P30685 S140F Polymorphism 0.377 0.736 0.53 -6 0.429 P30711 D141N Polymorphism 0.569 0.146 0.80 -27 0.167 P30711 V169I Polymorphism 0.800 0.122 0.25 2 0.431 P30793 A74V Disease NA 0.877 0.02 28 0.847 P30793 G83A Disease 0.524 0.821 0.00 36 0.841 P30793 G90V Disease 0.608 0.888 0.00 46 0.879 P30793 L71Q Disease NA 0.779 0.01 13 0.688 P30793 L79P Disease 0.941 0.947 0.00 54 0.932 P30793 P23L Disease NA 0.215 0.04 4 0.217 P30793 R88P Disease 0.834 0.927 0.00 55 0.923 P30793 R88W Disease 0.941 0.891 0.00 61 0.925 P30793 C141R Disease 0.952 0.922 0.00 79 0.886 P30793 C141W Disease 0.982 0.899 0.00 79 0.870 P30793 D115N Disease 0.242 0.667 0.01 -1 0.459 P30793 D134V Disease 0.894 0.877 0.00 51 0.900 P30793 F234S Disease 0.376 0.839 0.00 56 0.869 P30793 G108D Disease 0.859 0.912 0.00 64 0.923 P30793 G201E Disease 0.700 0.912 0.00 56 0.902 P30793 G203R Disease 0.199 0.864 0.02 36 0.618 P30793 H144P Disease 0.885 0.925 0.00 65 0.910 P30793 H153P Disease 0.676 0.939 0.00 54 0.771 P30793 I135K Disease 0.915 0.773 0.00 72 0.905 P30793 K224R Disease 0.361 0.594 0.47 -19 0.362 P30793 L163R Disease 0.627 0.932 0.01 58 0.881 P30793 M102K Disease 0.672 0.924 0.00 53 0.905 P30793 M102R Disease 0.668 0.915 0.00 55 0.909 P30793 M211I Disease 0.206 0.796 0.01 52 0.793 P30793 M211V Disease 0.308 0.827 0.00 56 0.863 P30793 M213V Disease 0.387 0.870 0.06 53 0.605 P30793 M221T Disease 0.147 0.574 0.40 -20 0.080 P30793 P199L Disease 0.795 0.809 0.00 21 0.834 P30793 Q180R Disease 0.824 0.875 0.00 46 0.875 P30793 R178S Disease 0.892 0.910 0.00 63 0.906 P30793 R184H Disease 0.825 0.926 0.00 26 0.832 P30793 R241W Disease 0.385 0.919 0.00 57 0.886 P30793 R249S Disease 0.162 0.823 0.01 1 0.402 P30793 S176T Disease 0.520 0.707 0.00 20 0.611 P30793 T106I Disease 0.537 0.850 0.08 22 0.839 P30793 T186K Disease 0.835 0.851 0.00 54 0.901 P30793 V191I Disease 0.295 0.318 0.19 -41 0.328 P30837 A86V Polymorphism 0.629 0.691 0.00 28 0.652 P30837 L107R Polymorphism 0.601 0.322 1.00 -41 0.003 P30837 T202I Polymorphism 0.403 0.720 0.10 27 0.779 P30838 G309E Polymorphism 0.189 0.660 1.00 15 0.334 P30838 P329A Polymorphism 0.357 0.084 0.77 -13 0.148 P30926 T91I Polymorphism 0.243 0.218 0.02 2 0.263 P30926 S140G Polymorphism 0.432 0.163 0.34 -4 0.267 P30953 A143T Polymorphism 0.143 0.233 0.12 -22 0.163 P30953 P129L Polymorphism 0.921 0.912 0.03 64 0.934 P30954 M112I Polymorphism 0.576 0.829 0.08 5 0.651 P30968 E90K Disease 0.379 0.653 0.05 29 0.554 P30968 N10K Disease 0.338 0.136 0.92 32 0.227 P30968 A129D Disease 0.842 0.775 0.01 50 0.885 P30968 A171T Disease 0.681 0.720 0.03 26 0.789 P30968 Q106R Disease 0.715 0.689 1.00 36 0.737 P30968 R139H Disease 0.996 0.880 0.00 54 0.953 P30968 R262Q Disease 0.279 0.804 0.04 60 0.871 P30968 S168R Disease 0.236 0.763 0.17 14 0.525 P30968 S217R Disease 0.432 0.540 0.37 36 0.759 P30968 Y284C Disease 0.939 0.816 0.00 45 0.893 P30989 A72V Polymorphism 0.359 0.343 0.55 -26 0.189 P30989 Q275H Polymorphism NA 0.191 0.12 23 0.364 P30989 V304I Polymorphism 0.283 0.283 0.35 36 0.246 P31040 D38V Polymorphism NA 0.156 0.55 -9 0.221 P31040 A524V Disease 0.477 0.653 0.02 43 0.801 P31040 G555E Disease 0.195 0.685 0.17 19 0.357 P31040 R554W Disease 0.840 0.787 0.01 56 0.919 P31146 T443P Polymorphism 0.390 0.338 0.25 38 0.525 P31150 L92P Disease 0.711 0.849 0.00 11 0.859 P31150 R423P Disease NA 0.953 0.00 54 0.894 P31151 E28D Polymorphism 0.116 0.027 0.60 -18 0.039 P31152 V38M Polymorphism 0.238 0.558 0.16 2 0.388 P31213 G85D Disease 0.332 0.453 0.09 34 0.495 P31213 L55Q Disease 0.624 0.833 0.01 33 0.848 P31213 V89L Polymorphism 0.116 0.056 0.39 -45 0.077 P31213 A207D Disease 0.717 0.758 0.02 19 0.849 P31213 A228T Disease 0.818 0.843 0.10 52 0.913 P31213 E197D Disease 0.919 0.931 0.00 50 0.935 P31213 E200K Disease 0.572 0.896 0.10 48 0.864 P31213 G115D Disease 0.341 0.753 0.35 67 0.879 P31213 G123R Disease 0.924 0.920 0.02 64 0.940 P31213 G158R Disease 0.686 0.305 0.36 18 0.423 P31213 G183S Disease 0.483 0.909 0.07 45 0.860 P31213 G196S Disease 0.869 0.867 0.39 16 0.788 P31213 H231R Disease 0.805 0.599 0.60 16 0.774 P31213 L224H Polymorphism 0.874 0.838 0.00 46 0.899 P31213 L224M Polymorphism 0.550 0.651 0.34 -37 0.473 P31213 P181L Disease 0.986 0.935 0.00 58 0.960 P31213 P212R Disease 0.653 0.288 0.37 49 0.511 P31213 Q126R Disease 0.808 0.754 0.17 55 0.915 P31213 R145W Disease 0.855 0.646 0.03 47 0.807 P31213 R246Q Disease 0.834 0.789 0.01 67 0.929 P31213 R246W Disease 0.971 0.833 0.00 62 0.947 P31213 S245Y Disease 0.617 0.422 0.92 18 0.538 P31213 Y235F Disease 0.678 0.884 0.08 53 0.778 P31249 S129C Polymorphism 0.579 0.266 0.08 5 0.549 P31271 N372H Disease 0.860 0.812 0.00 64 0.933 P31271 Q371L Disease 0.786 0.887 0.00 47 0.887 P31276 S50I Polymorphism NA 0.240 0.05 36 0.092 P31277 G245D Polymorphism NA 0.143 0.57 28 0.234 P31323 E335D Polymorphism 0.092 0.312 0.59 -21 0.200 P31327 H337R Disease 0.927 0.953 0.00 78 0.950 P31327 K875E Disease 0.484 0.455 0.31 10 0.426 P31327 L843S Disease 0.950 0.735 0.01 30 0.855 P31327 Q810R Disease 0.782 0.837 0.13 34 0.861 P31327 R850H Disease 0.876 0.833 0.00 68 0.908 P31327 S918P Disease 0.586 0.883 0.00 27 0.881 P31327 T344A Polymorphism 0.317 0.595 0.02 23 0.569 P31327 T544M Disease 0.952 0.669 0.00 43 0.856 P31327 V457G Disease 0.764 0.354 0.01 18 0.620 P31327 F1266S Polymorphism 0.954 0.793 0.00 56 0.915 P31327 G1376S Polymorphism 0.219 0.165 0.74 -57 0.160 P31327 M1283L Polymorphism 0.303 0.706 0.16 11 0.294 P31358 I41M Polymorphism NA 0.198 NA 12 0.044 P31358 N40S Polymorphism NA 0.196 NA 1 0.053 P31391 F321S Polymorphism 0.702 0.314 1.00 -28 0.459 P31431 F12L Polymorphism NA 0.050 1.00 -48 0.011 P31512 I37T Polymorphism 0.882 0.463 0.01 39 0.706 P31512 E339Q Polymorphism 0.424 0.357 0.15 -20 0.316 P31512 G372S Polymorphism 0.363 0.385 0.55 7 0.208 P31512 L544R Polymorphism NA 0.555 0.00 57 0.691 P31512 T308S Polymorphism 0.422 0.116 0.84 -25 0.141 P31512 V323A Polymorphism 0.411 0.155 0.35 -22 0.196 P31513 A52T Disease 0.502 0.352 0.25 -15 0.472 P31513 E32K Disease 0.951 0.953 0.01 64 0.941 P31513 M66I Disease 0.561 0.353 0.10 15 0.602 P31513 N61S Disease 0.865 0.777 0.02 51 0.903 P31513 E158K Polymorphism NA 0.249 0.35 3 0.338 P31513 G503R Polymorphism 0.132 0.355 0.44 -29 0.086 P31513 M434I Disease 0.414 0.679 0.49 21 0.509 P31513 P153L Disease 0.966 0.885 0.00 43 0.926 P31513 R205C Polymorphism 0.951 0.547 0.02 4 0.756 P31513 R387L Disease 0.861 0.925 0.03 45 0.856 P31513 R492W Disease 0.948 0.979 0.00 48 0.925 P31513 V257M Polymorphism 0.298 0.173 0.19 -33 0.224 P31629 A1041V Polymorphism NA 0.097 0.01 18 0.202 P31629 L1538P Polymorphism NA 0.073 0.26 8 0.066 P31639 N654S Disease NA 0.477 0.02 15 0.493 P31641 I17M Polymorphism NA 0.228 0.14 -56 0.252 P31645 G56A Polymorphism NA 0.176 0.47 -23 0.157 P31645 F465L Polymorphism 0.673 0.263 0.36 -21 0.567 P31645 I425L Polymorphism 0.218 0.661 0.23 -49 0.410 P31645 I425V Polymorphism 0.177 0.080 0.66 -61 0.147 P31645 K201N Polymorphism 0.108 0.447 1.00 -42 0.065 P31645 L550V Polymorphism 0.277 0.436 0.25 -37 0.351 P31749 E17K Disease NA 0.581 0.05 52 0.674 P31749 V167A Polymorphism 0.308 0.389 1.00 -12 0.255 P31751 I188V Polymorphism 0.135 0.236 0.36 7 0.245 P31751 R208K Polymorphism 0.096 0.214 1.00 -33 0.185 P31785 C62G Disease 0.660 0.849 0.00 37 0.852 P31785 D39N Disease NA 0.337 0.27 -13 0.186 P31785 E68G Disease 0.606 0.333 0.09 14 0.544 P31785 E68K Disease 0.536 0.404 0.21 19 0.433 P31785 N84K Disease 0.596 0.296 0.07 29 0.467 P31785 T44S Polymorphism 0.130 0.026 0.85 -17 0.037 P31785 Y89C Disease 0.889 0.698 0.01 47 0.864 P31785 A156V Disease 0.583 0.198 0.04 19 0.395 P31785 C115F Disease 0.993 0.650 0.15 62 0.952 P31785 C115R Disease 0.991 0.867 0.01 72 0.970 P31785 C182R Disease 0.831 0.934 0.02 69 0.954 P31785 C231Y Disease 0.869 0.935 0.01 57 0.954 P31785 E109K Polymorphism 0.128 0.053 0.87 35 0.075 P31785 F227C Disease NA 0.181 0.14 53 0.319 P31785 G114D Disease 0.777 0.815 0.25 47 0.858 P31785 G232R Disease 0.830 0.435 0.36 56 0.647 P31785 H123P Disease 0.218 0.328 0.29 39 0.262 P31785 I153N Disease 0.476 0.370 0.23 38 0.446 P31785 L162H Disease 0.850 0.282 0.16 53 0.528 P31785 L172P Disease 0.850 0.801 0.00 42 0.850 P31785 L172Q Disease 0.817 0.600 0.00 46 0.805 P31785 L183S Disease 0.763 0.768 0.01 46 0.853 P31785 L230P Disease NA 0.568 0.10 41 0.726 P31785 L293Q Disease 0.499 0.203 0.05 19 0.343 P31785 M270R Disease 0.665 0.603 0.05 54 0.854 P31785 Q144P Disease 0.540 0.359 0.30 40 0.525 P31785 R222C Disease 0.771 0.479 0.01 46 0.695 P31785 R224W Disease 0.995 0.921 0.00 60 0.971 P31785 R226C Disease 0.845 0.473 0.01 56 0.765 P31785 R226H Disease 0.539 0.275 0.06 49 0.538 P31785 R285Q Disease 0.163 0.722 0.04 41 0.663 P31785 S241I Disease 0.744 0.650 0.00 50 0.867 P31785 W240C Disease 0.995 0.867 0.00 60 0.970 P31785 Y105C Disease 0.889 0.875 0.17 55 0.940 P31785 Y125N Disease 0.496 0.443 0.08 51 0.655 P31930 N301S Polymorphism 0.183 0.203 0.57 11 0.176 P31939 K426R Disease 0.430 0.853 0.01 15 0.554 P31942 G284A Polymorphism NA 0.196 0.40 -34 0.181 P31942 N163S Polymorphism 0.156 0.236 0.87 -28 0.127 P31994 Y258D Polymorphism 0.207 0.203 0.44 6 0.084 P31997 A45V Polymorphism 0.228 0.362 1.00 -2 0.266 P31997 G17V Polymorphism 0.302 0.868 0.01 6 0.705 P31997 R114K Polymorphism 0.067 0.232 0.98 -17 0.155 P32004 W9S Disease NA 0.547 0.03 50 0.585 P32004 H30N Polymorphism NA 0.173 0.10 -3 0.181 P32004 A415P Disease 0.838 0.371 0.08 17 0.603 P32004 A426D Disease 0.633 0.140 0.05 48 0.374 P32004 A691D Disease 0.969 0.860 0.00 49 0.953 P32004 A691T Disease 0.913 0.756 0.00 21 0.823 P32004 C264Y Disease 0.999 0.774 0.00 52 0.973 P32004 C497Y Disease 0.996 0.623 0.00 36 0.848 P32004 D202Y Disease 0.986 0.583 0.00 22 0.842 P32004 D598N Disease 0.946 0.239 0.19 23 0.434 P32004 D770N Disease 0.144 0.193 1.00 8 0.150 P32004 E309K Disease 0.625 0.182 0.62 35 0.197 P32004 G121S Disease 0.962 0.806 0.09 13 0.840 P32004 G268D Disease 0.981 0.575 0.01 54 0.971 P32004 G370R Disease 0.985 0.666 0.00 29 0.836 P32004 G452R Disease 0.871 0.704 0.00 44 0.863 P32004 G698R Disease 0.741 0.578 0.04 28 0.759 P32004 H210Q Disease 0.506 0.294 0.29 20 0.340 P32004 I179S Disease 0.889 0.422 0.00 38 0.594 P32004 I219T Disease 0.778 0.197 0.05 0 0.392 P32004 K655E Disease 0.160 0.340 0.90 1 0.135 P32004 L482P Disease 0.974 0.437 0.00 31 0.732 P32004 L935P Disease 0.555 0.684 0.06 3 0.658 P32004 M741T Disease 0.359 0.127 0.72 20 0.108 P32004 N408I Disease 0.889 0.427 0.07 49 0.662 P32004 P240L Disease 0.840 0.470 0.01 22 0.501 P32004 P941L Disease 0.854 0.899 0.01 32 0.869 P32004 R184Q Disease 0.954 0.276 0.09 28 0.533 P32004 R184W Disease 0.991 0.297 0.00 54 0.724 P32004 R386C Disease 0.640 0.214 0.03 43 0.509 P32004 R473C Disease 0.940 0.248 0.05 52 0.620 P32004 R632P Disease 0.670 0.292 0.17 34 0.563 P32004 R739W Polymorphism 0.810 0.500 0.02 44 0.802 P32004 R751P Disease 0.753 0.570 0.10 43 0.797 P32004 S542P Disease 0.452 0.115 0.27 34 0.290 P32004 S674C Disease 0.621 0.328 0.07 17 0.586 P32004 V421D Disease 0.972 0.285 0.00 27 0.653 P32004 V752M Disease 0.950 0.422 0.00 25 0.674 P32004 V768F Disease 0.779 0.470 0.03 58 0.757 P32004 W335C Disease 0.988 0.236 0.01 62 0.951 P32004 W335R Disease 0.979 0.307 0.01 57 0.649 P32004 Y194C Disease 0.983 0.181 0.01 55 0.600 P32004 Y784C Disease 0.928 0.699 0.00 20 0.888 P32004 G1239E Polymorphism 0.095 0.153 1.00 -3 0.104 P32004 S1194L Disease 0.797 0.820 0.03 -48 0.800 P32004 S1224L Disease 0.956 0.925 0.00 20 0.934 P32004 Y1070C Disease 0.416 0.309 0.19 34 0.468 P32119 D153E Polymorphism 0.262 0.563 0.38 -10 0.349 P32189 A382T Polymorphism 0.803 0.883 0.01 54 0.736 P32189 D446V Disease 0.963 0.931 0.00 61 0.822 P32189 N232H Polymorphism 0.413 0.446 0.05 6 0.435 P32189 N294D Disease 0.792 0.820 0.00 68 0.896 P32189 S185N Polymorphism 0.334 0.382 0.60 -50 0.119 P32189 W509R Disease 0.582 0.871 0.00 75 0.914 P32241 R341M Polymorphism 0.154 0.663 0.00 60 0.704 P32241 R445L Polymorphism 0.716 0.645 0.02 51 0.844 P32243 R89G Disease 0.885 0.762 0.00 74 0.922 P32243 P133T Disease 0.517 0.510 0.09 0 0.479 P32243 P134A Disease 0.167 0.449 0.27 31 0.217 P32245 I226T Polymorphism 0.499 0.836 0.04 49 0.717 P32245 V103I Polymorphism 0.204 0.124 0.15 -36 0.171 P32247 T53P Polymorphism 0.633 0.729 0.24 22 0.676 P32248 M7V Polymorphism NA 0.117 0.00 5 0.074 P32297 R37H Polymorphism NA 0.725 0.01 23 0.648 P32298 R65L Polymorphism NA 0.237 0.50 17 0.288 P32298 A116T Polymorphism NA 0.168 0.58 -34 0.172 P32298 A440V Polymorphism 0.378 0.583 0.08 12 0.486 P32298 A495T Polymorphism 0.227 0.256 1.00 -28 0.207 P32298 L425P Polymorphism 0.688 0.922 0.03 63 0.880 P32298 T183R Polymorphism 0.465 0.414 0.06 18 0.384 P32298 V247I Polymorphism 0.139 0.040 1.00 -22 0.025 P32302 G344S Polymorphism 0.100 0.171 0.51 -24 0.116 P32320 K27Q Polymorphism 0.301 0.382 0.63 -36 0.268 P32322 A179T Disease 0.896 0.902 0.00 49 0.902 P32322 A189V Polymorphism 0.646 0.628 0.16 10 0.584 P32322 A257T Disease 0.817 0.873 0.01 30 0.777 P32322 G206R Disease 0.697 0.809 0.02 38 0.859 P32322 G206W Disease 0.844 0.760 0.00 27 0.858 P32322 R119G Disease 0.971 0.873 0.00 67 0.928 P32322 R119H Disease 0.970 0.848 0.00 68 0.927 P32322 R251H Disease 0.806 0.897 0.01 39 0.844 P32322 R266Q Disease 0.516 0.134 0.32 -26 0.221 P32456 P285A Polymorphism 0.212 0.205 0.80 -19 0.225 P32519 N58S Polymorphism 0.153 0.116 0.16 3 0.143 P32519 T343S Polymorphism 0.401 0.123 1.00 -15 0.114 P32745 R336C Polymorphism 0.552 0.232 0.04 24 0.612 P32745 S411T Polymorphism NA 0.091 0.00 39 0.154 P32754 A33T Polymorphism 0.706 0.944 0.03 3 0.808 P32754 A268V Disease 0.876 0.921 0.00 54 0.936 P32754 I335M Disease 0.844 0.880 0.01 44 0.890 P32754 V340L Polymorphism 0.242 0.470 0.80 -29 0.285 P32754 Y160C Disease 0.913 0.939 0.00 34 0.901 P32780 S285F Polymorphism 0.218 0.283 0.11 27 0.342 P32856 K54R Polymorphism 0.248 0.350 0.45 -2 0.313 P32926 T912A Polymorphism 0.038 0.080 0.06 -4 0.082 P32926 V509M Polymorphism 0.478 0.097 0.10 41 0.277 P32927 P696S Polymorphism 0.642 0.133 0.00 51 0.283 P32927 V652M Polymorphism 0.116 0.028 0.69 -27 0.018 P32929 S403I Polymorphism NA 0.159 0.00 -8 0.193 P32942 D143G Polymorphism 0.123 0.127 1.00 -2 0.050 P33076 A658G Polymorphism 0.334 0.151 0.43 4 0.165 P33076 F962S Disease 0.577 0.476 0.01 45 0.698 P33076 G500A Polymorphism 0.215 0.835 0.02 5 0.562 P33076 L469P Disease 0.799 0.853 0.01 52 0.912 P33076 S781L Polymorphism 0.221 0.195 0.32 18 0.267 P33076 V782A Polymorphism 0.068 0.131 0.49 0 0.077 P33151 I503T Polymorphism 0.068 0.328 0.32 -27 0.146 P33241 A100T Polymorphism NA 0.016 NA -34 0.024 P33241 Q229K Polymorphism NA 0.046 0.24 -22 0.038 P33260 T385M Polymorphism 0.621 0.897 0.01 46 0.607 P33261 E92D Polymorphism 0.162 0.435 0.13 -14 0.256 P33261 I19L Polymorphism 0.263 0.132 1.00 -43 0.100 P33261 L17P Polymorphism 0.881 0.732 0.04 43 0.835 P33261 S51G Polymorphism 0.226 0.252 0.32 -8 0.293 P33261 R144H Polymorphism 0.657 0.620 0.02 -4 0.741 P33261 R150H Polymorphism 0.257 0.284 0.32 -33 0.300 P33261 R410C Polymorphism 0.345 0.506 0.02 7 0.424 P33261 R433W Polymorphism 0.996 0.972 0.00 69 0.935 P33261 W120R Polymorphism 0.941 0.930 0.00 70 0.934 P33316 P100S Polymorphism NA 0.129 0.02 -27 0.233 P33527 G671V Polymorphism 0.717 0.747 0.00 51 0.865 P33527 R633Q Polymorphism 0.175 0.209 0.60 -13 0.189 P33527 R723Q Polymorphism 0.229 0.895 0.64 31 0.377 P33527 S1512L Polymorphism 0.263 0.323 0.30 -23 0.196 P33527 V1146I Polymorphism NA 0.076 0.47 -17 0.126 P33763 D54G Polymorphism 0.229 0.304 0.06 -13 0.310 P33765 M266K Polymorphism 0.317 0.708 0.04 1 0.535 P33897 A99D Disease 0.496 0.361 0.23 14 0.464 P33897 C88W Disease 0.782 0.647 0.11 57 0.835 P33897 E90K Disease 0.617 0.571 0.27 53 0.758 P33897 N13T Polymorphism NA 0.057 NA -23 0.010 P33897 S98L Disease 0.606 0.225 0.98 -6 0.524 P33897 A141T Disease 0.563 0.413 0.38 13 0.565 P33897 A294T Disease 0.855 0.806 0.07 55 0.895 P33897 A616V Disease 0.930 0.856 0.05 29 0.833 P33897 A626D Disease 0.721 0.677 0.02 54 0.857 P33897 A626T Disease 0.530 0.249 0.22 27 0.542 P33897 A646P Disease 0.474 0.898 0.28 30 0.823 P33897 C631Y Disease 0.872 0.837 0.02 42 0.866 P33897 D194H Disease 0.969 0.898 0.07 71 0.945 P33897 D200N Disease 0.972 0.902 0.13 66 0.945 P33897 D200V Disease 0.992 0.857 0.00 68 0.949 P33897 D221G Disease 0.916 0.618 0.43 50 0.883 P33897 D629H Disease 0.988 0.864 0.00 72 0.924 P33897 D638Y Disease 0.784 0.704 0.02 40 0.839 P33897 E271K Disease 0.617 0.352 0.60 -6 0.522 P33897 E291D Disease 0.956 0.771 0.04 49 0.859 P33897 E291K Disease 0.980 0.900 0.04 61 0.946 P33897 E302K Disease 0.915 0.920 0.34 58 0.941 P33897 E609G Disease 0.485 0.739 0.01 49 0.843 P33897 E609K Disease 0.314 0.939 0.03 59 0.910 P33897 E630G Disease 0.972 0.750 0.00 66 0.919 P33897 F540S Disease 0.739 0.170 0.35 39 0.408 P33897 G116R Disease 0.895 0.779 0.03 55 0.873 P33897 G266R Disease 0.895 0.879 0.59 35 0.872 P33897 G277R Disease 0.963 0.884 0.01 65 0.941 P33897 G277W Disease 0.988 0.842 0.00 61 0.938 P33897 G298D Disease 0.973 0.964 0.28 46 0.923 P33897 G343D Disease 0.967 0.915 0.36 63 0.941 P33897 G343S Disease 0.944 0.737 0.73 34 0.815 P33897 G507V Disease 0.992 0.936 0.01 71 0.929 P33897 G512S Disease 0.981 0.894 0.00 66 0.922 P33897 G522W Disease 0.958 0.850 0.04 51 0.914 P33897 G529S Disease 0.915 0.777 0.40 14 0.818 P33897 G608D Disease 0.989 0.949 0.00 74 0.886 P33897 H667D Disease 0.984 0.830 0.13 64 0.942 P33897 K217E Disease 0.906 0.495 0.38 51 0.811 P33897 K276E Disease 0.151 0.189 1.00 3 0.114 P33897 K336M Disease 0.981 0.370 0.07 47 0.827 P33897 L107P Disease 0.854 0.705 0.07 47 0.863 P33897 L190P Disease 0.829 0.348 0.10 66 0.815 P33897 L211P Disease 0.869 0.799 0.01 66 0.920 P33897 L220P Disease 0.848 0.616 0.09 59 0.898 P33897 L229P Disease 0.818 0.711 0.00 63 0.914 P33897 L322P Disease 0.263 0.571 0.38 20 0.555 P33897 L503P Disease 0.838 0.925 0.02 29 0.869 P33897 L654P Disease 0.852 0.895 0.09 28 0.825 P33897 M566K Disease 0.729 0.367 0.31 50 0.638 P33897 N148S Disease 0.685 0.626 0.39 16 0.783 P33897 N214D Disease 0.268 0.525 0.66 4 0.285 P33897 P143S Disease 0.739 0.427 0.17 19 0.583 P33897 P218T Disease 0.966 0.643 0.59 50 0.912 P33897 P263L Disease 0.880 0.761 0.12 27 0.835 P33897 P484R Disease 0.991 0.889 0.02 48 0.928 P33897 P534L Disease 0.979 0.671 0.28 42 0.926 P33897 P543L Disease 0.979 0.664 0.02 31 0.841 P33897 P560L Disease 0.990 0.632 0.03 51 0.904 P33897 P560R Disease 0.990 0.737 0.04 69 0.920 P33897 P560S Disease 0.985 0.528 0.33 50 0.901 P33897 Q178E Disease 0.183 0.339 1.00 28 0.353 P33897 Q544R Disease 0.936 0.808 0.01 49 0.825 P33897 Q556R Disease 0.936 0.596 0.28 62 0.905 P33897 R104C Disease 0.987 0.781 0.01 48 0.912 P33897 R104H Disease 0.972 0.582 0.04 39 0.842 P33897 R113C Disease 0.495 0.347 0.08 41 0.535 P33897 R113P Disease 0.266 0.397 0.25 51 0.570 P33897 R152C Disease 0.802 0.509 0.18 51 0.881 P33897 R152L Disease 0.547 0.490 0.68 43 0.553 P33897 R152P Disease 0.654 0.583 0.24 65 0.873 P33897 R152S Disease 0.230 0.349 0.49 22 0.339 P33897 R163H Disease 0.945 0.824 0.07 60 0.936 P33897 R163P Disease 0.949 0.913 0.06 69 0.943 P33897 R182P Disease 0.404 0.579 0.22 36 0.731 P33897 R189W Disease 0.934 0.323 0.15 57 0.704 P33897 R274W Disease 0.805 0.666 0.01 29 0.792 P33897 R280C Disease 0.911 0.949 0.02 65 0.943 P33897 R285P Disease 0.726 0.927 0.07 67 0.931 P33897 R389G Disease 0.655 0.612 0.40 37 0.737 P33897 R389H Disease 0.611 0.392 0.15 59 0.686 P33897 R401Q Disease 0.736 0.714 0.34 28 0.784 P33897 R401W Disease 0.952 0.822 0.03 52 0.925 P33897 R418W Disease 0.995 0.915 0.02 63 0.950 P33897 R518Q Disease 0.976 0.722 0.22 40 0.882 P33897 R518W Disease 0.995 0.913 0.00 48 0.915 P33897 R554H Disease 0.560 0.668 0.06 51 0.689 P33897 R591P Disease 0.654 0.956 0.21 49 0.903 P33897 R591Q Disease 0.370 0.678 0.30 45 0.621 P33897 R591W Disease 0.855 0.886 0.18 49 0.918 P33897 R617C Disease 0.994 0.935 0.00 66 0.933 P33897 R617G Disease 0.979 0.907 0.00 59 0.925 P33897 R617H Disease 0.988 0.884 0.00 60 0.925 P33897 R660P Disease 0.853 0.969 0.01 77 0.935 P33897 R660W Disease 0.947 0.926 0.00 71 0.936 P33897 S103R Disease 0.490 0.421 0.48 18 0.461 P33897 S108L Disease 0.627 0.582 0.16 23 0.598 P33897 S108W Disease 0.923 0.747 0.03 39 0.865 P33897 S149N Disease 0.676 0.514 0.38 0 0.769 P33897 S161P Disease 0.329 0.543 0.25 41 0.520 P33897 S213C Disease 0.802 0.619 0.12 27 0.770 P33897 S342P Disease 0.395 0.583 0.33 16 0.653 P33897 S514R Disease 0.956 0.924 0.00 73 0.922 P33897 S515F Disease 0.826 0.893 0.00 41 0.874 P33897 S552P Disease 0.603 0.738 0.01 53 0.749 P33897 S606L Disease 0.915 0.916 0.00 63 0.917 P33897 S606P Disease 0.900 0.920 0.00 66 0.917 P33897 S633I Disease 0.749 0.858 0.00 56 0.909 P33897 S633R Disease 0.698 0.882 0.00 65 0.905 P33897 S636I Disease 0.637 0.670 0.03 45 0.817 P33897 T105I Disease 0.767 0.778 0.10 33 0.832 P33897 T105P Disease 0.805 0.822 0.04 58 0.931 P33897 T198K Disease 0.593 0.666 0.06 66 0.824 P33897 T254M Disease 0.751 0.319 0.10 18 0.615 P33897 T254P Disease 0.632 0.582 0.14 52 0.854 P33897 T632I Disease 0.937 0.843 0.03 56 0.911 P33897 T668I Disease 0.653 0.181 0.06 4 0.410 P33897 T693M Disease 0.292 0.230 0.08 28 0.337 P33897 V224E Disease 0.562 0.388 0.36 56 0.645 P33897 V635M Disease 0.660 0.737 0.03 27 0.715 P33897 W339R Disease 0.894 0.803 0.40 59 0.910 P33897 W679R Disease 0.726 0.925 0.05 60 0.924 P33897 Y174C Disease 0.992 0.895 0.08 60 0.948 P33897 Y174D Disease 0.989 0.885 0.01 64 0.949 P33897 Y174S Disease 0.983 0.769 0.02 50 0.931 P33897 Y181C Disease 0.978 0.916 0.01 70 0.949 P33897 Y296C Disease 0.971 0.880 0.03 67 0.946 P33981 D758N Polymorphism 0.195 0.266 0.08 -5 0.269 P33991 E460G Polymorphism 0.415 0.305 0.14 25 0.417 P33991 L650M Polymorphism 0.096 0.324 0.36 -17 0.223 P33992 T180S Polymorphism 0.141 0.142 0.74 -37 0.109 P33992 V258I Polymorphism 0.180 0.118 0.52 -16 0.206 P33993 R114Q Polymorphism NA 0.214 0.25 -24 0.215 P34059 C79Y Disease 0.988 0.869 0.00 78 0.937 P34059 D60N Disease 0.897 0.861 0.00 42 0.806 P34059 F69V Disease 0.356 0.707 0.03 62 0.866 P34059 F97V Disease 0.416 0.215 1.00 -20 0.162 P34059 G23R Disease 0.140 0.444 0.45 2 0.241 P34059 G42E Disease 0.962 0.908 0.00 68 0.938 P34059 G47R Disease 0.624 0.890 0.01 72 0.860 P34059 G96C Disease 0.782 0.890 0.01 48 0.879 P34059 G96V Disease 0.652 0.834 0.01 49 0.885 P34059 L15M Disease 0.287 0.313 0.21 -29 0.295 P34059 L36P Disease 0.695 0.835 0.00 25 0.879 P34059 M41L Disease 0.123 0.353 0.82 0 0.209 P34059 P77R Disease 0.586 0.608 0.08 65 0.820 P34059 R61W Disease 0.747 0.887 0.00 41 0.870 P34059 R90W Disease 0.986 0.935 0.00 59 0.944 P34059 R94C Disease 0.988 0.948 0.00 70 0.947 P34059 R94G Disease 0.961 0.919 0.00 67 0.944 P34059 R94L Disease 0.970 0.960 0.00 64 0.938 P34059 S53F Disease 0.599 0.274 0.00 -24 0.482 P34059 S80L Disease 0.441 0.695 0.01 51 0.851 P34059 A107T Disease 0.359 0.200 0.14 -11 0.269 P34059 A203V Disease 0.313 0.274 0.20 4 0.208 P34059 A231G Polymorphism 0.295 0.329 0.32 22 0.386 P34059 A257T Disease 0.359 0.273 0.20 8 0.364 P34059 A291D Disease 0.541 0.905 0.02 51 0.885 P34059 A291T Disease 0.359 0.659 0.04 30 0.626 P34059 A351V Disease 0.211 0.264 0.28 6 0.315 P34059 A392V Disease 0.354 0.631 0.03 18 0.517 P34059 A393S Polymorphism 0.166 0.271 0.01 -5 0.296 P34059 D171A Disease 0.458 0.360 0.78 0 0.388 P34059 D233N Disease 0.407 0.245 0.47 -26 0.184 P34059 D344E Disease 0.953 0.808 0.00 71 0.899 P34059 D344N Disease 0.971 0.816 0.00 75 0.938 P34059 D388N Disease 0.072 0.384 1.00 4 0.224 P34059 E185G Disease NA 0.208 0.34 20 0.280 P34059 E260D Disease 0.287 0.627 0.00 29 0.524 P34059 E450V Disease 0.955 0.792 0.00 53 0.936 P34059 F156C Disease 0.993 0.867 0.00 61 0.935 P34059 F156S Disease 0.985 0.814 0.00 55 0.930 P34059 F167V Disease 0.416 0.274 0.25 -19 0.291 P34059 F284V Disease 0.416 0.178 0.03 -1 0.197 P34059 F346L Disease 0.235 0.156 0.59 -9 0.127 P34059 F452I Disease 0.450 0.157 0.30 6 0.252 P34059 G116S Disease 0.958 0.622 0.00 54 0.960 P34059 G139S Disease 0.998 0.929 0.00 65 0.937 P34059 G155E Disease 0.990 0.869 0.00 78 0.923 P34059 G155R Disease 0.991 0.827 0.00 79 0.905 P34059 G168R Disease 0.682 0.616 0.55 20 0.747 P34059 G247D Disease 0.607 0.717 0.62 18 0.493 P34059 G290S Disease 0.999 0.840 0.00 66 0.932 P34059 G301C Disease NA 0.893 0.00 8 0.813 P34059 G309R Disease 0.967 0.825 0.01 40 0.878 P34059 G340D Disease 0.559 0.640 0.21 55 0.716 P34059 H150Y Disease 0.472 0.256 0.06 20 0.350 P34059 H166Q Disease 0.526 0.243 0.39 32 0.544 P34059 H398D Disease 0.320 0.442 0.01 30 0.441 P34059 H401Y Disease 0.426 0.519 0.33 9 0.459 P34059 I113F Disease NA 0.409 0.03 8 0.383 P34059 I178V Polymorphism NA 0.025 0.79 9 0.069 P34059 K310N Disease 0.913 0.905 0.00 63 0.924 P34059 L307P Disease 0.739 0.876 0.24 26 0.811 P34059 L345P Disease 0.706 0.863 0.00 39 0.862 P34059 L352P Disease 0.706 0.818 0.00 56 0.896 P34059 L369P Disease 0.428 0.861 0.17 51 0.872 P34059 L395P Disease 0.706 0.550 0.25 18 0.703 P34059 L395V Disease 0.263 0.064 0.75 -22 0.074 P34059 M318R Disease 0.547 0.738 0.09 48 0.783 P34059 M343R Disease 0.474 0.681 0.00 65 0.870 P34059 M391V Disease 0.217 0.382 0.57 -1 0.189 P34059 M494V Disease 0.268 0.208 0.64 26 0.263 P34059 N164T Disease 0.441 0.302 0.69 -7 0.262 P34059 N204K Disease 0.391 0.390 0.09 21 0.272 P34059 N407H Disease 0.284 0.332 0.51 -23 0.269 P34059 N487S Disease 0.389 0.217 1.00 2 0.234 P34059 P125L Disease 0.628 0.679 0.03 26 0.754 P34059 P151L Disease 0.987 0.778 0.01 14 0.901 P34059 P151S Disease 0.979 0.681 0.05 35 0.873 P34059 P179H Disease NA 0.505 0.54 10 0.421 P34059 P179L Disease NA 0.588 0.53 10 0.425 P34059 P179S Disease NA 0.416 0.50 12 0.323 P34059 P357L Disease 0.145 0.153 1.00 -22 0.101 P34059 P484S Disease 0.531 0.303 0.61 0 0.448 P34059 Q111R Disease NA 0.256 0.20 12 0.254 P34059 R253W Disease 0.724 0.712 0.05 24 0.780 P34059 R259Q Disease 0.438 0.261 0.48 -16 0.189 P34059 R361G Disease 0.503 0.422 0.03 39 0.535 P34059 R376Q Disease 0.085 0.239 0.50 -36 0.139 P34059 R380S Disease 0.279 0.465 0.13 4 0.334 P34059 R380T Disease 0.307 0.476 0.15 4 0.415 P34059 R386C Disease 0.748 0.735 0.11 34 0.744 P34059 R386H Disease 0.436 0.466 0.08 -11 0.345 P34059 S135R Disease 0.224 0.901 0.01 57 0.823 P34059 S162F Disease 0.654 0.437 0.16 -24 0.465 P34059 S287L Disease 0.501 0.819 0.04 53 0.819 P34059 S295F Disease NA 0.807 0.03 -14 0.684 P34059 S341R Disease 0.464 0.730 0.00 63 0.876 P34059 S470P Disease 0.232 0.733 0.27 -43 0.333 P34059 T312S Disease 0.302 0.127 0.33 -1 0.197 P34059 V138A Disease 0.340 0.475 0.34 44 0.418 P34059 V239F Disease 0.513 0.629 0.29 -31 0.407 P34059 W141C Disease 0.990 0.935 0.00 78 0.922 P34059 W141R Disease 0.983 0.938 0.00 80 0.889 P34059 W230G Disease 0.645 0.244 0.14 53 0.570 P34059 W325C Disease 0.840 0.709 0.09 51 0.836 P34059 W409S Disease 0.063 0.555 0.90 27 0.136 P34096 T16S Polymorphism 0.277 0.169 0.02 -72 0.287 P34741 A59T Polymorphism 0.420 0.097 0.50 -11 0.180 P34810 A340T Polymorphism 0.116 0.444 0.24 -9 0.213 P34820 H293R Polymorphism 0.120 0.425 0.65 3 0.229 P34896 L474F Polymorphism 0.272 0.120 0.00 8 0.219 P34913 K55R Polymorphism NA 0.129 0.00 -13 0.073 P34913 R52Q Polymorphism NA 0.335 1.00 22 0.223 P34913 C154Y Polymorphism NA 0.931 0.00 59 0.774 P34913 M369V Polymorphism NA 0.225 0.77 5 0.187 P34913 P225L Polymorphism NA 0.279 0.03 13 0.252 P34913 R103C Polymorphism NA 0.464 0.00 28 0.535 P34925 R224C Polymorphism 0.661 0.506 0.06 30 0.679 P34931 A268T Polymorphism 0.488 0.780 0.00 16 0.789 P34931 E558A Polymorphism NA 0.180 0.78 -15 0.142 P34931 E602K Polymorphism NA 0.760 0.20 -18 0.537 P34931 T479M Polymorphism 0.652 0.926 0.01 35 0.865 P34947 Q41L Polymorphism NA 0.368 0.22 21 0.322 P34947 G122S Polymorphism NA 0.111 0.98 -21 0.098 P34947 R304H Polymorphism 0.346 0.082 0.07 -16 0.226 P34947 T129M Polymorphism NA 0.204 0.02 36 0.361 P34949 M51T Disease 0.683 0.909 0.00 51 0.915 P34949 D131N Disease 0.795 0.941 0.00 43 0.884 P34949 G250S Disease 0.736 0.919 0.00 39 0.843 P34949 I140T Disease 0.624 0.702 0.01 25 0.677 P34949 I398T Disease 0.538 0.706 0.01 43 0.861 P34949 M138T Disease 0.683 0.877 0.00 34 0.885 P34949 R152Q Disease 0.578 0.895 0.11 44 0.802 P34949 R219Q Disease 0.230 0.709 0.15 -13 0.455 P34949 R295H Disease 0.827 0.845 0.00 69 0.927 P34949 R418H Disease 0.481 0.935 0.01 47 0.849 P34949 S102L Disease 0.829 0.859 0.00 15 0.896 P34949 Y129C Disease 0.978 0.896 0.00 39 0.940 P34949 Y255C Disease 0.366 0.731 0.07 41 0.784 P34972 Q63R Polymorphism 0.053 0.471 0.94 38 0.147 P34972 H316Y Polymorphism 0.070 0.283 0.46 39 0.103 P34981 I168M Polymorphism NA 0.250 0.21 2 0.204 P34982 F31Y Polymorphism 0.328 0.836 0.00 34 0.783 P34982 T240I Polymorphism 0.594 0.894 0.02 44 0.747 P34995 A71T Polymorphism 0.111 0.139 0.81 23 0.122 P34995 H256R Polymorphism 0.138 0.110 0.38 20 0.090 P35030 T224S Polymorphism 0.206 0.038 0.83 -49 0.041 P35070 C7G Polymorphism 0.154 0.232 NA -27 0.102 P35070 L124M Polymorphism 0.284 0.430 0.08 -29 0.399 P35125 W475R Polymorphism NA 0.119 0.37 59 0.103 P35212 P71S Polymorphism 0.998 0.952 0.00 51 0.917 P35212 V130I Polymorphism 0.056 0.048 1.00 -48 0.036 P35221 A179V Polymorphism NA 0.056 0.26 15 0.085 P35222 D32G Disease NA 0.681 0.00 63 0.855 P35222 D32Y Disease NA 0.731 0.00 70 0.861 P35222 G34E Disease NA 0.801 0.00 69 0.884 P35222 S33F Disease NA 0.712 0.00 49 0.831 P35222 S33Y Disease NA 0.758 0.00 49 0.829 P35222 S37A Disease NA 0.464 0.00 17 0.586 P35222 S37C Disease NA 0.746 0.00 34 0.739 P35222 S37F Disease NA 0.636 0.00 43 0.723 P35222 T41I Disease NA 0.687 0.00 32 0.722 P35222 M688V Polymorphism 0.203 0.079 1.00 4 0.071 P35226 C18Y Polymorphism 0.997 0.990 0.00 77 0.968 P35228 S608L Polymorphism 0.465 0.329 0.66 -12 0.390 P35228 R1009C Polymorphism 0.782 0.750 0.01 50 0.901 P35237 M90V Polymorphism 0.110 0.202 0.78 0 0.145 P35237 G153S Polymorphism 0.355 0.626 0.22 -16 0.495 P35240 F62S Disease NA 0.932 0.00 63 0.934 P35240 M77V Disease NA 0.695 0.48 27 0.384 P35240 E106G Disease 0.303 0.518 0.38 24 0.275 P35240 G197C Disease 0.650 0.860 0.01 23 0.847 P35240 K413E Disease 0.157 0.166 0.68 -7 0.110 P35240 K533T Disease 0.441 0.183 0.02 31 0.328 P35240 K579M Disease 0.579 0.205 0.04 11 0.482 P35240 L141P Disease 0.967 0.909 0.00 61 0.930 P35240 L234R Disease 0.965 0.939 0.00 67 0.931 P35240 L360P Disease 0.742 0.762 0.30 38 0.701 P35240 L535P Disease 0.712 0.557 0.02 39 0.700 P35240 L539H Disease 0.827 0.534 0.02 39 0.778 P35240 N220Y Disease 0.668 0.778 0.01 49 0.888 P35240 Q344H Polymorphism 0.430 0.299 0.06 11 0.384 P35240 Q538P Disease 0.680 0.551 0.08 54 0.831 P35240 R351H Polymorphism 0.199 0.479 0.08 -3 0.411 P35240 T352M Disease 0.281 0.315 0.01 17 0.400 P35241 D490N Polymorphism 0.193 0.180 0.50 -11 0.128 P35241 D578N Disease 0.671 0.551 0.28 9 0.650 P35241 K328E Polymorphism 0.372 0.344 0.80 -13 0.264 P35247 E309K Polymorphism 0.164 0.155 0.91 14 0.100 P35247 S290T Polymorphism 0.454 0.217 0.92 51 0.258 P35250 A232V Polymorphism 0.880 0.843 0.00 8 0.820 P35251 E692D Polymorphism NA 0.314 0.13 -6 0.305 P35251 Q955K Polymorphism NA 0.572 0.51 34 0.466 P35251 R613L Polymorphism NA 0.475 0.04 32 0.415 P35251 S1146L Polymorphism NA 0.103 NA 9 0.083 P35270 P163L Disease 0.594 0.645 0.09 30 0.756 P35270 R150G Disease 0.289 0.612 1.00 51 0.495 P35318 P85R Polymorphism 0.171 0.069 0.55 -7 0.068 P35321 H42Q Polymorphism 0.243 0.131 0.39 -7 0.111 P35346 A52V Polymorphism 0.065 0.249 1.00 -41 0.170 P35346 G37R Polymorphism 0.176 0.693 0.55 42 0.363 P35346 P109S Polymorphism 0.100 0.044 0.70 -54 0.076 P35346 T333M Polymorphism 0.144 0.138 0.08 25 0.255 P35346 V267I Polymorphism 0.103 0.230 0.15 -42 0.235 P35346 W105R Polymorphism 0.997 0.923 0.00 85 0.917 P35348 C347R Polymorphism 0.128 0.853 0.63 24 0.291 P35348 E465D Polymorphism NA 0.069 0.12 -2 0.029 P35367 G270E Polymorphism NA 0.226 1.00 -8 0.279 P35368 V51G Polymorphism 0.428 0.660 0.00 28 0.772 P35372 G63V Polymorphism 0.338 0.274 0.29 19 0.372 P35372 N40D Polymorphism 0.494 0.467 0.29 43 0.446 P35372 D274N Polymorphism 0.717 0.207 0.27 1 0.454 P35372 R260H Polymorphism 0.857 0.713 0.00 28 0.812 P35410 D288E Polymorphism 0.235 0.270 0.44 -11 0.272 P35414 V300I Polymorphism 0.256 0.044 0.82 -21 0.149 P35443 V646I Polymorphism 0.194 0.176 0.54 -5 0.135 P35443 V737I Polymorphism 0.266 0.203 0.43 -1 0.218 P35453 I322L Disease 0.393 0.914 0.00 41 0.818 P35453 Q325R Disease 0.677 0.904 0.00 63 0.922 P35453 R306W Disease 0.951 0.907 0.00 58 0.949 P35453 S316C Disease 0.791 0.766 0.00 46 0.880 P35462 S9G Polymorphism NA 0.306 1.00 7 0.206 P35475 A75T Disease 0.237 0.298 0.18 -24 0.217 P35475 A79V Disease 0.452 0.252 0.16 19 0.346 P35475 G51D Disease 0.790 0.816 0.00 61 0.924 P35475 H82P Disease 0.322 0.809 0.07 17 0.554 P35475 R89Q Disease 0.609 0.866 0.00 67 0.893 P35475 R89W Disease 0.919 0.950 0.00 71 0.953 P35475 A327P Disease 0.391 0.546 0.14 0 0.460 P35475 D349N Disease 0.602 0.734 0.44 44 0.820 P35475 D349Y Disease 0.873 0.865 0.19 51 0.842 P35475 E182K Disease 0.591 0.829 0.00 69 0.901 P35475 F602I Disease 0.121 0.500 0.00 38 0.276 P35475 G116R Polymorphism 0.117 0.132 0.69 -10 0.053 P35475 G208D Disease 0.790 0.796 0.04 25 0.789 P35475 G409R Disease 0.372 0.218 0.17 27 0.382 P35475 L218P Disease 0.441 0.759 0.03 35 0.755 P35475 L238Q Disease 0.553 0.869 0.11 37 0.846 P35475 L346R Disease 0.791 0.900 0.02 68 0.924 P35475 L490P Disease 0.374 0.658 0.01 18 0.659 P35475 M133I Disease 0.426 0.506 0.16 58 0.733 P35475 M504T Disease 0.517 0.512 0.02 38 0.744 P35475 N350I Disease 0.810 0.659 0.33 43 0.775 P35475 P496L Disease 0.816 0.710 1.00 22 0.662 P35475 P533R Disease 0.826 0.737 0.26 31 0.841 P35475 Q380R Disease 0.549 0.525 0.35 40 0.751 P35475 R105Q Polymorphism 0.127 0.071 0.56 -30 0.071 P35475 R363C Disease 0.903 0.864 0.01 57 0.942 P35475 R383H Disease 0.440 0.347 0.15 26 0.470 P35475 R489P Disease 0.402 0.693 0.08 28 0.690 P35475 R492P Disease 0.331 0.756 0.04 15 0.642 P35475 R619G Disease 0.466 0.714 0.00 45 0.778 P35475 R628P Disease 0.528 0.792 0.00 39 0.824 P35475 S260F Disease 0.626 0.474 0.00 52 0.719 P35475 S423R Disease 0.630 0.500 0.19 58 0.863 P35475 T366P Disease 0.545 0.413 0.22 17 0.446 P35475 T388R Disease 0.506 0.531 0.53 45 0.552 P35475 V279A Polymorphism 0.267 0.070 0.15 9 0.090 P35475 V454I Polymorphism 0.048 0.107 0.56 -40 0.060 P35475 W626R Disease 0.336 0.760 0.00 58 0.840 P35498 E78D Disease NA 0.611 0.00 2 0.505 P35498 A239T Disease 0.724 0.292 0.05 45 0.599 P35498 C959R Disease 0.788 0.701 0.01 71 0.951 P35498 D188V Disease NA 0.573 0.00 66 0.839 P35498 D366E Disease 0.757 0.899 0.00 59 0.926 P35498 F902C Disease 0.849 0.889 0.00 41 0.913 P35498 G177E Disease NA 0.934 0.00 66 0.931 P35498 G265W Disease 0.981 0.930 0.00 49 0.937 P35498 G979R Disease 0.068 0.918 0.00 59 0.805 P35498 H939Q Disease 0.904 0.236 0.02 60 0.654 P35498 I227S Disease 0.686 0.838 0.00 31 0.893 P35498 I252N Disease 0.804 0.756 0.00 37 0.871 P35498 L986F Disease NA 0.819 0.03 36 0.833 P35498 M145T Disease NA 0.564 0.00 46 0.789 P35498 M934I Disease 0.610 0.353 0.04 56 0.583 P35498 M960V Disease 0.698 0.342 0.00 60 0.657 P35498 N985I Disease NA 0.871 0.00 46 0.903 P35498 R101Q Disease NA 0.900 0.03 43 0.804 P35498 R118S Disease NA 0.868 0.00 31 0.871 P35498 R377Q Disease 0.838 0.212 0.32 52 0.466 P35498 R393H Disease 0.896 0.764 0.05 45 0.841 P35498 R931C Disease 0.940 0.722 0.00 66 0.963 P35498 R946C Disease 0.959 0.493 0.00 70 0.974 P35498 R946H Disease 0.904 0.512 0.00 70 0.963 P35498 R946S Disease 0.863 0.522 0.00 60 0.916 P35498 S103G Disease NA 0.739 0.04 48 0.727 P35498 T112I Disease NA 0.597 0.02 35 0.794 P35498 T297I Disease NA 0.213 0.21 -2 0.333 P35498 T808S Disease 0.666 0.768 0.03 9 0.725 P35498 T875M Disease 0.912 0.470 0.00 20 0.699 P35498 V944A Disease NA 0.478 0.00 51 0.650 P35498 V983A Disease NA 0.718 0.01 33 0.825 P35498 W190R Disease NA 0.825 0.00 67 0.841 P35498 W280R Disease 0.599 0.636 0.86 47 0.602 P35498 Y426N Disease 0.925 0.829 0.00 33 0.900 P35498 Y790C Disease 0.747 0.483 0.01 61 0.850 P35498 A1067T Polymorphism NA 0.171 0.53 -28 0.127 P35498 A1326P Disease 0.843 0.799 0.01 43 0.874 P35498 A1685D Disease 0.569 0.927 0.01 42 0.894 P35498 A1685V Disease 0.424 0.932 0.01 24 0.836 P35498 D1742G Disease 0.512 0.664 0.02 30 0.550 P35498 D1866Y Disease 0.941 0.735 0.00 57 0.917 P35498 E1238D Disease 0.749 0.809 0.00 42 0.709 P35498 E1881D Disease 0.316 0.549 0.17 7 0.490 P35498 F1263L Disease 0.758 0.887 0.00 54 0.931 P35498 F1463S Disease 0.917 0.842 0.00 50 0.935 P35498 F1499L Disease 0.756 0.776 0.06 15 0.685 P35498 F1661S Disease 0.878 0.833 0.01 21 0.816 P35498 F1692S Disease 0.921 0.943 0.00 42 0.916 P35498 F1808L Disease 0.649 0.576 0.01 36 0.657 P35498 F1831S Disease 0.921 0.724 0.00 43 0.878 P35498 G1233R Disease 0.918 0.660 0.04 44 0.836 P35498 G1674R Disease 0.828 0.908 0.02 46 0.899 P35498 G1749E Disease 0.781 0.546 0.04 17 0.723 P35498 I1656M Disease 0.764 0.817 0.23 13 0.687 P35498 K1270T Disease 0.882 0.712 0.00 38 0.905 P35498 L1207P Disease NA 0.694 0.01 60 0.775 P35498 L1265P Disease 0.815 0.434 0.01 35 0.662 P35498 L1355P Disease 0.948 0.553 0.00 41 0.802 P35498 L1461I Disease 0.228 0.331 0.49 -31 0.270 P35498 M1780T Disease 0.885 0.679 0.01 42 0.829 P35498 M1852T Disease 0.571 0.907 0.00 53 0.740 P35498 N1011I Disease 0.888 0.714 0.07 32 0.876 P35498 P1632S Disease 0.912 0.587 0.00 42 0.900 P35498 P1668A Disease 0.896 0.737 0.00 40 0.846 P35498 Q1450R Disease 0.830 0.578 0.00 61 0.915 P35498 Q1489H Disease 0.888 0.286 0.28 -15 0.567 P35498 Q1489K Disease 0.706 0.346 0.45 5 0.572 P35498 R1648C Disease 0.969 0.739 0.00 42 0.900 P35498 R1648H Disease 0.929 0.742 0.00 31 0.850 P35498 R1657C Disease 0.953 0.859 0.00 56 0.947 P35498 S1231R Disease 0.638 0.610 0.00 64 0.922 P35498 T1709I Disease 0.899 0.813 0.00 51 0.926 P35498 T1909I Disease 0.897 0.911 0.00 46 0.880 P35498 V1335M Disease 0.828 0.572 0.00 35 0.755 P35498 V1353L Disease 0.658 0.701 0.02 10 0.710 P35498 V1366I Disease 0.530 0.580 0.00 11 0.545 P35498 V1390M Disease 0.765 0.500 0.00 43 0.673 P35498 V1428A Disease 0.771 0.408 0.01 31 0.636 P35498 V1611F Disease 0.847 0.641 0.00 33 0.821 P35498 V1857L Disease 0.549 0.326 0.04 12 0.598 P35498 W1204R Disease 0.823 0.712 0.01 74 0.817 P35498 W1358S Disease 0.953 0.586 0.00 44 0.828 P35498 W1434R Disease 0.952 0.844 0.00 74 0.971 P35498 W1812G Disease 0.929 0.757 0.00 58 0.924 P35498 Y1462C Disease 0.965 0.556 0.00 58 0.945 P35498 Y1781C Disease 0.817 0.765 0.00 31 0.889 P35499 A715T Disease 0.212 0.790 0.01 5 0.516 P35499 E452K Disease 0.788 0.680 0.22 50 0.647 P35499 F671S Disease 0.736 0.773 0.00 35 0.856 P35499 I141V Disease NA 0.302 0.27 -18 0.288 P35499 M135V Polymorphism NA 0.262 0.58 11 0.355 P35499 Q270K Disease 0.727 0.871 0.43 58 0.829 P35499 R222W Disease 0.976 0.937 0.00 60 0.979 P35499 R669H Disease 0.858 0.857 0.00 59 0.953 P35499 R672C Disease 0.892 0.880 0.00 59 0.961 P35499 R672G Disease 0.704 0.791 0.00 54 0.857 P35499 R672H Disease 0.758 0.854 0.00 60 0.942 P35499 R672S Disease 0.661 0.865 0.00 51 0.914 P35499 R675G Disease 0.851 0.776 0.00 55 0.965 P35499 R675Q Disease 0.800 0.832 0.00 57 0.961 P35499 R675W Disease 0.965 0.855 0.00 57 0.985 P35499 S246L Polymorphism 0.856 0.511 0.01 39 0.829 P35499 S804F Disease 0.514 0.722 0.00 42 0.816 P35499 S804N Disease 0.284 0.654 0.26 8 0.283 P35499 T704M Disease 0.913 0.606 0.03 34 0.875 P35499 V445M Disease NA 0.851 0.01 33 0.837 P35499 V781I Disease 0.274 0.510 0.51 24 0.323 P35499 A1152D Disease 0.906 0.649 0.00 57 0.956 P35499 A1156T Disease NA 0.769 0.10 49 0.582 P35499 A1481D Disease 0.828 0.876 0.00 55 0.962 P35499 F1473S Disease 0.878 0.882 0.00 36 0.852 P35499 F1705I Disease 0.792 0.734 0.02 21 0.771 P35499 G1306A Disease 0.369 0.321 0.01 14 0.404 P35499 G1306E Disease 0.523 0.517 0.10 19 0.445 P35499 G1306V Disease 0.580 0.587 0.00 20 0.612 P35499 G1456E Disease 0.774 0.803 0.06 41 0.845 P35499 I1160V Disease 0.393 0.578 0.04 38 0.517 P35499 I1310N Disease 0.903 0.751 0.00 38 0.817 P35499 L1433R Disease 0.794 0.885 0.00 46 0.898 P35499 L1436P Disease 0.711 0.845 0.00 30 0.847 P35499 M1476I Disease 0.615 0.808 0.23 15 0.459 P35499 M1592V Disease 0.774 0.397 0.01 33 0.621 P35499 N1297K Disease 0.870 0.409 0.10 56 0.715 P35499 P1158S Disease 0.858 0.705 0.03 27 0.827 P35499 R1132Q Disease NA 0.866 0.00 58 0.911 P35499 R1135H Disease NA 0.835 0.00 54 0.902 P35499 R1448C Disease 0.953 0.904 0.00 48 0.943 P35499 R1448H Disease 0.890 0.889 0.01 47 0.924 P35499 R1448L Disease 0.862 0.924 0.01 37 0.870 P35499 T1313M Disease 0.944 0.579 0.00 42 0.877 P35499 V1293I Disease 0.106 0.782 0.04 -1 0.294 P35499 V1442E Disease 0.776 0.579 0.00 67 0.866 P35499 V1589M Disease 0.810 0.178 0.00 -10 0.445 P35503 Q6R Polymorphism NA 0.195 0.28 -3 0.182 P35503 R49W Polymorphism 0.986 0.712 0.00 8 0.870 P35503 T78I Polymorphism 0.836 0.219 0.01 13 0.516 P35503 W11R Polymorphism NA 0.528 0.42 8 0.475 P35503 A158V Polymorphism 0.754 0.466 0.01 -8 0.576 P35504 D50E Polymorphism 0.888 0.158 1.00 -64 0.105 P35504 L63P Polymorphism 0.862 0.539 1.00 -32 0.192 P35504 G259R Polymorphism 0.428 0.801 0.05 43 0.827 P35504 T144S Polymorphism 0.657 0.115 1.00 -59 0.155 P35520 A69P Polymorphism NA 0.534 0.12 -44 0.440 P35520 G85R Disease NA 0.894 0.00 60 0.916 P35520 H65R Disease NA 0.384 0.28 33 0.424 P35520 P49L Disease NA 0.457 0.00 25 0.564 P35520 P78R Disease NA 0.459 0.22 -4 0.317 P35520 P88S Disease NA 0.880 0.00 55 0.909 P35520 R58W Disease NA 0.277 0.00 43 0.407 P35520 A114V Disease 0.792 0.729 0.03 32 0.846 P35520 A155T Disease 0.857 0.911 0.02 36 0.739 P35520 A155V Disease 0.881 0.877 0.00 46 0.871 P35520 A226T Disease 0.437 0.257 0.18 6 0.202 P35520 A231P Disease 0.719 0.918 0.12 47 0.874 P35520 A288P Disease NA 0.395 0.17 42 0.576 P35520 A288T Disease NA 0.155 0.33 3 0.210 P35520 A331E Disease 0.945 0.859 0.00 40 0.882 P35520 A331V Disease 0.876 0.875 0.00 28 0.865 P35520 A355P Disease 0.796 0.922 0.04 37 0.850 P35520 A361T Disease 0.644 0.803 0.03 19 0.833 P35520 C109R Disease 0.684 0.842 0.20 61 0.912 P35520 C165Y Disease 0.671 0.853 0.21 40 0.855 P35520 C275Y Disease 0.711 0.778 0.00 21 0.858 P35520 C370Y Disease 0.683 0.800 0.01 45 0.869 P35520 D198V Disease 0.652 0.484 0.06 41 0.730 P35520 D234N Disease 0.402 0.275 0.46 14 0.412 P35520 D376N Disease 0.816 0.847 0.04 61 0.914 P35520 D444N Disease 0.205 0.729 0.00 12 0.499 P35520 E128D Disease 0.511 0.706 0.56 -32 0.432 P35520 E131D Disease 0.878 0.927 0.03 25 0.877 P35520 E144K Disease 0.889 0.928 0.00 67 0.927 P35520 E176K Disease 0.634 0.939 0.00 56 0.904 P35520 E239K Disease 0.670 0.928 0.00 74 0.932 P35520 E302K Disease 0.220 0.102 1.00 -3 0.066 P35520 G116R Disease 0.492 0.908 0.06 69 0.919 P35520 G139R Disease 0.505 0.940 0.02 45 0.880 P35520 G148R Disease 0.998 0.936 0.00 73 0.949 P35520 G151R Disease 0.957 0.931 0.00 66 0.939 P35520 G305R Disease 0.768 0.868 0.00 75 0.922 P35520 G307S Disease 0.522 0.904 0.06 61 0.656 P35520 G347S Disease 0.859 0.945 0.01 67 0.930 P35520 I143M Disease 0.723 0.495 0.01 40 0.796 P35520 I152M Disease 0.746 0.742 0.00 -4 0.644 P35520 I278T Disease 0.565 0.464 0.01 45 0.676 P35520 I435T Disease 0.410 0.790 0.00 16 0.635 P35520 K102N Disease 0.295 0.259 0.32 3 0.327 P35520 K102Q Disease 0.395 0.172 0.19 0 0.253 P35520 K384E Disease 0.470 0.859 0.03 61 0.912 P35520 K384N Disease 0.609 0.825 0.03 48 0.875 P35520 L101P Disease 0.322 0.657 0.21 -14 0.500 P35520 L154Q Disease 0.924 0.857 0.00 37 0.872 P35520 L338P Disease 0.960 0.894 0.00 51 0.932 P35520 L456P Disease NA 0.785 0.02 23 0.799 P35520 L539S Disease NA 0.949 0.00 38 0.847 P35520 M126V Disease 0.612 0.785 0.15 53 0.724 P35520 M173V Disease 0.439 0.684 0.09 33 0.509 P35520 M391I Disease 0.391 0.554 0.04 60 0.802 P35520 N228K Disease 0.645 0.650 0.01 64 0.909 P35520 N228S Disease 0.801 0.740 0.01 56 0.912 P35520 P145L Disease 0.824 0.866 0.00 38 0.865 P35520 P290L Disease NA 0.325 0.18 15 0.413 P35520 P422L Disease 0.582 0.168 0.07 25 0.232 P35520 Q526K Disease NA 0.150 1.00 -15 0.088 P35520 R121C Disease 0.974 0.947 0.00 70 0.938 P35520 R121H Disease 0.921 0.919 0.00 71 0.924 P35520 R121L Disease 0.862 0.956 0.00 63 0.930 P35520 R125P Disease 0.709 0.903 0.18 61 0.911 P35520 R125Q Disease 0.432 0.313 0.52 19 0.343 P35520 R125W Disease 0.920 0.840 0.02 35 0.796 P35520 R224H Disease 0.509 0.306 0.19 -19 0.504 P35520 R266G Disease 0.718 0.621 0.04 37 0.710 P35520 R266K Disease 0.396 0.618 0.38 -13 0.421 P35520 R336C Disease 0.939 0.899 0.00 48 0.898 P35520 R336H Disease 0.836 0.849 0.09 27 0.865 P35520 R369C Disease 0.863 0.685 0.18 29 0.805 P35520 R369H Disease 0.693 0.581 0.55 9 0.695 P35520 R379Q Disease 0.467 0.274 0.12 52 0.472 P35520 R379W Disease 0.796 0.730 0.10 51 0.911 P35520 R439Q Disease 0.399 0.727 0.31 22 0.500 P35520 R491C Disease 0.538 0.588 0.02 35 0.520 P35520 S349N Disease 0.943 0.895 0.00 69 0.920 P35520 S352N Disease 0.723 0.747 0.10 40 0.848 P35520 S466L Disease 0.346 0.404 0.01 26 0.392 P35520 T191M Disease 0.795 0.814 0.00 45 0.869 P35520 T257M Disease 0.975 0.920 0.00 68 0.942 P35520 T262M Disease 0.597 0.791 0.17 36 0.544 P35520 T262R Disease 0.743 0.916 0.01 63 0.925 P35520 T353M Disease 0.540 0.700 0.00 2 0.690 P35520 T434N Disease 0.397 0.459 0.01 35 0.552 P35520 V168A Disease 0.551 0.534 0.17 30 0.489 P35520 V168M Disease 0.731 0.682 0.05 54 0.890 P35520 V180A Disease 0.447 0.388 0.23 -5 0.339 P35520 V320A Disease 0.485 0.312 0.00 21 0.414 P35520 V354M Disease 0.262 0.662 0.54 -38 0.311 P35520 V371M Disease 0.883 0.859 0.00 44 0.873 P35520 V454E Disease 0.141 0.274 1.00 11 0.150 P35520 V534D Disease NA 0.827 0.00 70 0.913 P35523 A313T Disease 0.686 0.634 0.12 12 0.759 P35523 A415V Disease 0.899 0.536 0.02 55 0.830 P35523 A437T Polymorphism 0.102 0.243 0.59 -42 0.180 P35523 D136G Disease 0.814 0.715 0.03 41 0.810 P35523 E291K Disease 0.997 0.939 0.00 72 0.959 P35523 F161V Disease 0.238 0.424 0.01 -13 0.364 P35523 F167L Disease 0.255 0.287 0.14 -30 0.284 P35523 F307S Disease 0.943 0.857 0.00 34 0.865 P35523 F413C Disease 0.893 0.771 0.00 67 0.892 P35523 F708L Disease 0.094 0.106 0.78 16 0.146 P35523 G200R Disease 0.998 0.909 0.00 68 0.932 P35523 G230E Disease 0.983 0.934 0.00 68 0.957 P35523 G285E Disease 0.958 0.932 0.00 68 0.955 P35523 G482R Disease 0.998 0.940 0.00 71 0.959 P35523 I290M Disease 0.742 0.563 0.01 20 0.769 P35523 I329T Disease 0.649 0.373 0.07 21 0.614 P35523 I556N Disease 0.840 0.651 0.00 39 0.808 P35523 M485V Disease 0.443 0.453 0.44 1 0.295 P35523 P480L Disease 0.985 0.903 0.00 56 0.952 P35523 P727L Polymorphism 0.275 0.229 1.00 -18 0.229 P35523 Q552R Disease 0.955 0.441 0.14 65 0.914 P35523 R105C Disease 0.793 0.828 0.02 27 0.855 P35523 R317Q Disease 0.782 0.748 0.02 14 0.777 P35523 R338Q Disease 0.658 0.409 0.13 17 0.576 P35523 R496S Disease 0.972 0.928 0.00 40 0.927 P35523 V165G Disease 0.852 0.500 0.00 34 0.781 P35523 V236L Disease 0.865 0.886 0.03 18 0.879 P35523 V286A Disease 0.909 0.767 0.01 40 0.859 P35523 V327I Disease 0.155 0.075 0.81 -20 0.076 P35523 V563I Disease 0.308 0.316 0.01 17 0.410 P35523 Y150C Disease 0.782 0.637 0.06 40 0.789 P35523 Y261C Disease 0.671 0.615 0.19 12 0.748 P35527 L160F Disease 0.958 0.914 0.00 43 0.904 P35527 L160V Disease 0.949 0.899 0.01 50 0.929 P35527 L168S Disease 0.984 0.827 0.00 30 0.895 P35527 L458F Disease 0.912 0.867 0.00 41 0.870 P35527 M157R Disease 0.986 0.939 0.00 60 0.943 P35527 M157T Disease 0.981 0.925 0.00 47 0.913 P35527 M157V Disease 0.966 0.922 0.01 47 0.913 P35527 N161H Disease 0.992 0.861 0.00 52 0.940 P35527 N161I Disease 0.994 0.873 0.00 43 0.903 P35527 N161K Disease 0.985 0.857 0.00 44 0.900 P35527 N161S Disease 0.977 0.833 0.00 37 0.903 P35527 N161Y Disease 0.992 0.859 0.00 51 0.939 P35527 Q172P Disease 0.780 0.872 0.00 24 0.869 P35527 R163P Disease 0.976 0.935 0.00 60 0.941 P35527 R163Q Disease 0.929 0.828 0.00 40 0.864 P35527 R163W Disease 0.991 0.919 0.00 44 0.921 P35527 V171M Disease 0.998 0.921 0.00 42 0.919 P35544 T53I Polymorphism 0.431 0.334 0.01 41 0.243 P35548 L154P Disease 0.928 0.879 0.00 61 0.912 P35548 P148H Disease 0.956 0.264 0.01 49 0.725 P35548 R172H Disease 0.893 0.909 0.00 63 0.913 P35555 C89F Disease NA 0.887 0.00 21 0.789 P35555 R62C Disease NA 0.717 0.00 58 0.846 P35555 Y20C Disease NA 0.203 0.18 -31 0.268 P35555 A705T Disease NA 0.240 0.28 2 0.174 P35555 C111R Disease NA 0.890 0.18 39 0.826 P35555 C123Y Disease NA 0.956 0.02 75 0.930 P35555 C129Y Disease NA 0.958 0.00 55 0.856 P35555 C154S Disease NA 0.851 0.46 9 0.679 P35555 C166F Disease NA 0.814 0.03 68 0.903 P35555 C166S Disease NA 0.808 0.20 57 0.809 P35555 C177R Disease NA 0.820 0.88 69 0.873 P35555 C224R Disease NA 0.686 0.38 71 0.801 P35555 C476G Disease NA 0.800 0.00 51 0.919 P35555 C504F Disease NA 0.703 0.03 61 0.930 P35555 C541Y Disease NA 0.581 0.04 72 0.905 P35555 C570Y Disease NA 0.779 0.22 62 0.968 P35555 C587Y Disease NA 0.743 0.00 72 0.978 P35555 C596Y Disease NA 0.761 0.00 71 0.979 P35555 C598W Disease NA 0.684 0.00 73 0.972 P35555 C628K Disease NA 0.692 0.00 74 0.977 P35555 C652S Disease NA 0.691 0.00 61 0.718 P35555 C661R Disease NA 0.778 0.03 57 0.886 P35555 C661Y Disease NA 0.737 0.19 32 0.525 P35555 C683R Disease NA 0.495 0.22 72 0.662 P35555 C685W Disease NA 0.608 0.03 68 0.883 P35555 C711Y Disease NA 0.765 0.02 65 0.929 P35555 C734F Disease NA 0.782 0.00 55 0.917 P35555 C748Y Disease NA 0.781 0.00 61 0.977 P35555 C750G Disease NA 0.713 0.00 64 0.981 P35555 C776G Disease NA 0.648 0.03 42 0.436 P35555 C776Y Disease NA 0.655 0.01 62 0.870 P35555 C781R Disease NA 0.819 0.00 64 0.994 P35555 C781Y Disease NA 0.805 0.00 30 0.681 P35555 C816S Disease NA 0.579 0.41 48 0.402 P35555 C832Y Disease NA 0.628 0.28 49 0.852 P35555 C862R Disease NA 0.887 0.21 69 0.832 P35555 C890G Disease NA 0.577 0.04 46 0.467 P35555 C890R Disease NA 0.775 0.04 66 0.589 P35555 C908R Disease NA 0.634 0.08 54 0.581 P35555 C921G Disease NA 0.585 0.27 51 0.397 P35555 C926R Disease NA 0.835 0.05 72 0.992 P35555 C996R Disease NA 0.461 0.15 53 0.537 P35555 D490Y Disease NA 0.513 0.01 55 0.626 P35555 D654N Disease NA 0.363 0.00 20 0.370 P35555 D723A Disease NA 0.525 0.07 34 0.798 P35555 D723V Disease NA 0.595 0.01 36 0.801 P35555 E913G Disease NA 0.476 0.25 46 0.657 P35555 G560S Disease NA 0.701 0.00 60 0.939 P35555 G592D Disease NA 0.620 0.16 73 0.470 P35555 G985E Disease NA 0.598 0.09 51 0.413 P35555 G985R Disease NA 0.468 0.05 47 0.480 P35555 I329T Polymorphism NA 0.179 0.51 48 0.196 P35555 N548I Disease NA 0.402 0.09 37 0.408 P35555 R114C Disease NA 0.489 0.06 -11 0.405 P35555 R122C Disease NA 0.545 0.05 50 0.646 P35555 R240C Disease NA 0.465 0.03 56 0.553 P35555 R439G Disease NA 0.082 0.05 10 0.136 P35555 R545C Disease NA 0.311 0.01 64 0.535 P35555 R627C Disease NA 0.231 0.02 58 0.532 P35555 R636I Disease NA 0.187 0.02 62 0.398 P35555 S115C Disease NA 0.234 0.17 12 0.260 P35555 S681Y Disease NA 0.243 0.46 51 0.338 P35555 V984I Disease NA 0.289 0.90 -2 0.213 P35555 W217G Disease NA 0.633 0.40 61 0.637 P35555 W366C Disease NA 0.612 0.01 60 0.667 P35555 Y635C Disease NA 0.433 0.01 55 0.646 P35555 Y746C Disease NA 0.402 0.00 40 0.601 P35555 A1337P Disease 0.570 0.166 0.03 48 0.465 P35555 A2160P Disease NA 0.129 0.29 43 0.259 P35555 A2385T Disease NA 0.246 0.51 -19 0.179 P35555 C1044Y Disease 0.981 0.842 0.06 77 0.993 P35555 C1053R Disease 0.791 0.843 0.03 74 0.989 P35555 C1055G Disease 0.979 0.797 0.64 66 0.991 P35555 C1055W Disease 0.996 0.767 0.02 76 0.995 P35555 C1055Y Disease 0.995 0.840 0.04 71 0.971 P35555 C1074R Disease 0.997 0.780 0.01 57 0.977 P35555 C1086W Disease 0.923 0.732 0.03 70 0.974 P35555 C1117G Disease NA 0.624 0.00 62 0.924 P35555 C1117Y Disease NA 0.721 0.00 67 0.986 P35555 C1129Y Disease NA 0.816 0.00 69 0.996 P35555 C1153S Disease NA 0.738 0.00 42 0.510 P35555 C1153Y Disease NA 0.713 0.00 39 0.622 P35555 C1171W Disease NA 0.693 0.00 72 0.981 P35555 C1223Y Disease 0.999 0.847 0.00 68 0.985 P35555 C1242Y Disease 0.999 0.775 0.00 68 0.971 P35555 C1249S Disease 0.949 0.680 0.07 49 0.842 P35555 C1265R Disease 0.999 0.815 0.00 79 0.979 P35555 C1278S Disease 0.998 0.721 0.00 61 0.958 P35555 C1284G Disease 0.996 0.617 0.00 48 0.882 P35555 C1333S Disease 0.999 0.609 0.03 35 0.735 P35555 C1339Y Disease 0.999 0.776 0.00 50 0.966 P35555 C1374S Disease 0.997 0.694 0.01 47 0.864 P35555 C1389R Disease 0.975 0.807 0.00 78 0.993 P35555 C1402R Disease 0.975 0.756 0.00 76 0.967 P35555 C1429S Disease 0.982 0.834 0.00 63 0.996 P35555 C1513R Disease 0.994 0.816 0.00 77 0.997 P35555 C1564F Disease 0.789 0.561 0.00 59 0.756 P35555 C1564Y Disease 0.826 0.601 0.00 62 0.945 P35555 C1589F Disease 0.789 0.803 0.00 69 0.941 P35555 C1610G Disease 0.625 0.603 0.00 55 0.689 P35555 C1631G Disease 0.625 0.782 0.00 55 0.983 P35555 C1663R Disease 0.607 0.745 0.00 63 0.981 P35555 C1663Y Disease 0.707 0.767 0.00 60 0.973 P35555 C1770F Disease 0.772 0.734 0.48 57 0.952 P35555 C1791R Disease 0.763 0.827 0.22 73 0.988 P35555 C1791Y Disease 0.812 0.830 0.07 64 0.980 P35555 C1793W Disease 0.912 0.794 0.01 77 0.978 P35555 C1806S Disease NA 0.781 0.41 57 0.500 P35555 C1806Y Disease NA 0.692 0.09 74 0.942 P35555 C1833S Disease 0.554 0.767 0.57 70 0.990 P35555 C1835Y Disease 0.812 0.801 0.60 71 0.968 P35555 C1876Y Disease 0.812 0.736 0.00 77 0.981 P35555 C1895R Disease 0.763 0.753 0.00 70 0.985 P35555 C1900Y Disease 0.812 0.590 0.00 52 0.762 P35555 C1928G Disease 0.602 0.544 0.00 28 0.558 P35555 C1928R Disease 0.763 0.569 0.00 61 0.757 P35555 C1928Y Disease 0.812 0.616 0.00 51 0.768 P35555 C1971Y Disease 0.901 0.705 0.00 69 0.871 P35555 C1977Y Disease 0.901 0.765 0.00 64 0.968 P35555 C1998Y Disease 0.812 0.804 0.00 66 0.982 P35555 C2038Y Disease 0.812 0.773 0.00 46 0.907 P35555 C2085R Disease NA 0.589 0.00 64 0.691 P35555 C2099W Disease NA 0.562 0.01 69 0.894 P35555 C2111R Disease NA 0.891 0.00 60 0.792 P35555 C2111Y Disease NA 0.878 0.00 13 0.793 P35555 C2142Y Disease NA 0.825 0.01 69 0.996 P35555 C2151W Disease NA 0.671 0.00 73 0.966 P35555 C2221F Disease NA 0.736 0.00 59 0.973 P35555 C2221G Disease NA 0.687 0.00 58 0.954 P35555 C2221S Disease NA 0.753 0.00 41 0.825 P35555 C2251R Disease NA 0.687 0.00 72 0.974 P35555 C2258R Disease NA 0.702 0.06 31 0.523 P35555 C2307S Disease NA 0.776 0.00 46 0.912 P35555 C2339Y Disease NA 0.786 0.03 59 0.729 P35555 C2406Y Disease NA 0.668 0.00 52 0.883 P35555 C2442W Disease NA 0.613 0.00 72 0.954 P35555 C2489R Disease NA 0.767 0.08 60 0.963 P35555 C2500R Disease NA 0.705 0.01 74 0.980 P35555 C2500Y Disease NA 0.661 0.38 55 0.887 P35555 C2511R Disease NA 0.749 0.04 69 0.810 P35555 C2535W Disease NA 0.748 0.01 73 0.935 P35555 C2571R Disease NA 0.771 0.04 57 0.919 P35555 C2581F Disease NA 0.735 0.08 64 0.938 P35555 C2592S Disease NA 0.800 0.24 41 0.828 P35555 C2605R Disease NA 0.777 0.01 73 0.908 P35555 C2605Y Disease NA 0.827 0.81 66 0.814 P35555 C2652G Disease NA 0.810 0.00 36 0.829 P35555 C2663S Disease NA 0.795 0.00 63 0.949 P35555 D1072G Disease 0.545 0.402 0.04 56 0.672 P35555 D1113V Disease NA 0.435 0.00 59 0.565 P35555 D1155N Disease NA 0.354 0.00 40 0.403 P35555 D1404Y Disease 0.980 0.460 0.00 60 0.916 P35555 D2127E Disease NA 0.311 0.02 15 0.361 P35555 D2329E Polymorphism NA 0.249 1.00 -15 0.259 P35555 E1073K Disease 0.982 0.349 0.36 62 0.850 P35555 E1200G Disease 0.928 0.606 0.00 61 0.887 P35555 E1325Q Disease 0.985 0.545 0.00 35 0.766 P35555 E1366K Disease 0.570 0.769 0.00 62 0.812 P35555 E2447K Disease NA 0.722 0.00 39 0.628 P35555 E2570K Disease NA 0.455 0.05 55 0.538 P35555 E2610K Disease NA 0.408 0.02 52 0.547 P35555 G1013R Disease NA 0.642 0.02 51 0.435 P35555 G1058D Disease 0.990 0.610 0.01 63 0.940 P35555 G1475E Disease 0.987 0.764 0.00 71 0.948 P35555 G1475S Disease 0.978 0.761 0.00 61 0.946 P35555 G1796E Disease 0.693 0.583 0.24 78 0.727 P35555 G2536R Disease NA 0.361 0.18 51 0.397 P35555 G2618R Disease NA 0.357 0.61 50 0.337 P35555 G2627R Disease NA 0.700 0.11 61 0.448 P35555 G2668C Disease NA 0.725 0.00 41 0.816 P35555 H2623P Disease NA 0.187 0.20 21 0.337 P35555 I1048T Disease 0.421 0.269 0.13 19 0.357 P35555 I1048V Polymorphism 0.088 0.273 1.00 -7 0.155 P35555 I1909T Disease 0.427 0.290 0.38 9 0.350 P35555 I2269T Disease NA 0.298 0.38 10 0.328 P35555 I2585T Disease NA 0.263 0.67 29 0.358 P35555 K1023N Disease NA 0.205 0.07 -13 0.195 P35555 K1043R Disease 0.193 0.161 0.73 -23 0.109 P35555 M1576T Disease 0.120 0.170 0.25 19 0.091 P35555 N1131Y Disease NA 0.525 0.00 60 0.905 P35555 N1173K Disease NA 0.500 0.00 64 0.943 P35555 N1382S Disease 0.996 0.544 0.00 48 0.867 P35555 N1893K Disease 0.228 0.291 0.02 54 0.398 P35555 N2144S Disease NA 0.416 0.04 41 0.429 P35555 N2223H Disease NA 0.439 0.01 63 0.685 P35555 N2624K Disease NA 0.390 0.06 58 0.623 P35555 P1424A Disease 0.661 0.152 0.13 38 0.311 P35555 P1424S Disease 0.699 0.112 0.07 55 0.370 P35555 P1837S Disease 0.128 0.225 0.17 16 0.199 P35555 P2154R Disease NA 0.286 0.22 31 0.366 P35555 P2278S Polymorphism NA 0.612 0.42 -12 0.234 P35555 R1137P Disease NA 0.575 0.13 47 0.828 P35555 R1170H Disease NA 0.165 0.02 45 0.338 P35555 R1790P Disease 0.729 0.185 0.30 45 0.498 P35555 R1915S Disease 0.250 0.250 0.23 -7 0.171 P35555 R2282W Disease NA 0.251 0.03 41 0.393 P35555 R2335W Disease NA 0.325 0.02 54 0.615 P35555 R2680C Disease NA 0.672 0.07 61 0.765 P35555 R2726W Disease NA 0.815 0.00 51 0.795 P35555 T1887I Disease 0.545 0.173 0.15 1 0.319 P35555 V2018I Polymorphism 0.231 0.175 0.36 23 0.196 P35555 Y1101C Disease 0.822 0.310 0.02 62 0.820 P35555 Y1219C Disease 0.859 0.718 0.00 54 0.964 P35555 Y1261C Disease 0.813 0.771 0.01 63 0.969 P35555 Y1261D Disease 0.792 0.667 0.01 67 0.969 P35555 Y2113F Polymorphism NA 0.299 0.70 -10 0.174 P35555 Y2474C Disease NA 0.782 0.03 34 0.817 P35555 Y2629C Disease NA 0.311 0.00 39 0.538 P35556 E391K Disease NA 0.139 0.40 12 0.186 P35556 G754S Disease NA 0.517 0.50 -5 0.094 P35556 R681H Polymorphism NA 0.186 0.04 56 0.342 P35556 C1142F Disease 0.757 0.697 0.02 67 0.973 P35556 C1142R Disease 0.749 0.748 0.03 67 0.828 P35556 C1156F Disease NA 0.610 0.10 66 0.899 P35556 C1198Y Disease NA 0.585 0.01 51 0.628 P35556 C1240R Disease 0.991 0.681 0.00 69 0.986 P35556 C1246F Disease 0.996 0.754 0.00 61 0.984 P35556 C1253W Disease 0.838 0.677 0.05 69 0.943 P35556 C1253Y Disease 0.670 0.715 0.18 67 0.769 P35556 C1257W Disease 0.926 0.768 0.00 70 0.964 P35556 C1268R Disease 0.999 0.775 0.00 73 0.985 P35556 C1384F Disease 0.998 0.791 0.00 64 0.990 P35556 C1384Y Disease 0.999 0.809 0.00 66 0.992 P35556 C1425R Disease 0.998 0.791 0.00 71 0.991 P35556 C1434S Disease 0.942 0.845 0.00 18 0.875 P35556 D1115H Disease 0.754 0.396 0.04 47 0.617 P35556 D1408N Disease 0.584 0.691 0.12 45 0.473 P35556 E1161K Disease NA 0.500 0.08 62 0.641 P35556 G1057D Disease NA 0.793 0.18 64 0.539 P35556 G1179C Disease NA 0.829 0.04 25 0.824 P35556 I1093T Disease 0.421 0.254 0.73 20 0.361 P35556 L2581S Polymorphism NA 0.272 0.31 -4 0.291 P35556 N1091S Disease 0.440 0.508 0.67 54 0.351 P35556 S1122P Disease 0.579 0.268 0.21 37 0.530 P35556 S2580L Polymorphism NA 0.145 0.32 6 0.237 P35556 S2771P Polymorphism NA 0.350 0.30 -37 0.262 P35556 Y1146C Disease 0.822 0.280 0.16 50 0.549 P35557 A11T Polymorphism NA 0.247 0.62 -30 0.236 P35557 A53S Disease NA 0.302 0.29 -9 0.259 P35557 E70K Disease NA 0.866 0.00 53 0.832 P35557 G80A Disease 0.686 0.846 0.00 54 0.904 P35557 G80S Disease 0.660 0.834 0.00 46 0.826 P35557 R36W Disease NA 0.801 0.00 28 0.831 P35557 A119D Disease 0.349 0.568 0.02 55 0.708 P35557 A188T Disease 0.582 0.710 0.02 32 0.642 P35557 A259T Disease 0.499 0.523 0.13 13 0.693 P35557 A384T Disease 0.707 0.790 0.03 -6 0.786 P35557 C213R Disease 0.506 0.673 0.02 37 0.545 P35557 C382Y Disease 0.573 0.711 0.00 -3 0.563 P35557 E221K Disease 0.350 0.550 0.34 -20 0.373 P35557 E256K Disease 0.857 0.933 0.00 74 0.945 P35557 E279Q Disease 0.245 0.229 0.27 -24 0.254 P35557 E300K Disease 0.641 0.796 0.01 58 0.903 P35557 E300Q Disease 0.693 0.722 0.01 41 0.846 P35557 F150S Disease 0.934 0.786 0.00 58 0.929 P35557 G175R Disease 0.779 0.784 0.01 35 0.828 P35557 G227C Disease 0.974 0.890 0.00 63 0.947 P35557 G261E Disease 0.367 0.913 0.01 51 0.879 P35557 G261R Disease 0.364 0.859 0.02 38 0.714 P35557 G299R Disease 0.862 0.837 0.00 58 0.928 P35557 G385V Disease 0.549 0.769 0.00 22 0.691 P35557 H137R Disease 0.210 0.275 0.63 9 0.298 P35557 I110T Disease 0.258 0.834 0.01 53 0.587 P35557 K414E Disease 0.208 0.516 0.17 -22 0.324 P35557 L164P Disease 0.949 0.927 0.00 52 0.947 P35557 L309P Disease 0.779 0.731 0.01 52 0.891 P35557 M210K Disease 0.782 0.717 0.00 50 0.897 P35557 M210T Disease 0.631 0.670 0.01 39 0.801 P35557 R392C Disease 0.519 0.862 0.00 37 0.782 P35557 S131P Disease 0.527 0.370 0.21 9 0.577 P35557 S336L Disease 0.792 0.910 0.00 47 0.860 P35557 T168P Disease 0.886 0.883 0.00 58 0.933 P35557 T209M Disease 0.820 0.821 0.00 51 0.909 P35557 T228M Disease 0.739 0.821 0.00 61 0.854 P35557 V182M Disease 0.874 0.811 0.02 34 0.860 P35557 V203A Disease 0.753 0.738 0.01 6 0.785 P35557 V226M Disease 0.539 0.542 0.02 6 0.569 P35557 V367M Disease 0.627 0.528 0.01 16 0.578 P35557 V455M Disease 0.577 0.777 0.04 -13 0.589 P35557 W257R Disease 0.832 0.881 0.00 69 0.933 P35557 Y108H Disease 0.635 0.565 0.00 21 0.640 P35558 M60T Polymorphism 0.588 0.703 0.01 34 0.659 P35558 R55Q Polymorphism 0.132 0.604 0.31 -29 0.189 P35558 E276K Polymorphism 0.118 0.823 1.00 -22 0.222 P35558 P427S Polymorphism 0.622 0.932 0.01 25 0.875 P35558 V184L Polymorphism 0.459 0.165 1.00 -61 0.066 P35568 G971R Polymorphism 0.364 0.104 0.16 0 0.074 P35568 P158R Polymorphism 0.434 0.613 0.07 32 0.621 P35568 C1095Y Disease 0.662 0.586 0.06 20 0.659 P35568 D1137N Polymorphism 0.231 0.043 0.61 -20 0.032 P35568 S1043Y Disease 0.940 0.158 0.00 3 0.440 P35573 A701S Polymorphism 0.343 0.186 NA -11 0.319 P35573 G1448R Disease 0.972 0.979 NA 71 0.967 P35573 I1144N Polymorphism 0.172 0.268 NA -47 0.131 P35573 P1067S Polymorphism 0.242 0.424 NA -36 0.324 P35573 R1487G Polymorphism 0.264 0.387 NA 2 0.303 P35575 M5R Disease 0.879 0.842 0.00 63 0.938 P35575 A65P Disease 0.757 0.938 0.02 49 0.830 P35575 D38V Disease 0.947 0.959 0.00 47 0.924 P35575 G68R Disease 0.722 0.808 0.04 51 0.897 P35575 G81R Disease 0.687 0.961 0.00 34 0.854 P35575 K76N Disease 0.897 0.948 0.00 42 0.911 P35575 Q20R Disease 0.833 0.751 0.00 39 0.880 P35575 Q54P Disease 0.378 0.659 0.23 22 0.661 P35575 R83C Disease 0.771 0.978 0.00 75 0.954 P35575 R83H Disease 0.908 0.970 0.00 71 0.959 P35575 R83I Disease 0.908 0.907 0.00 73 0.949 P35575 T16A Disease 0.186 0.134 1.00 -12 0.077 P35575 T16R Disease 0.532 0.513 0.06 53 0.748 P35575 W63R Disease 0.768 0.914 0.00 55 0.832 P35575 W77R Disease 0.961 0.983 0.00 48 0.945 P35575 A124T Disease 0.182 0.579 0.05 -6 0.379 P35575 A241T Disease 0.808 0.796 0.00 5 0.870 P35575 E110K Disease 0.876 0.884 0.00 53 0.933 P35575 F177C Disease 0.968 0.951 0.00 55 0.976 P35575 F322L Disease 0.714 0.734 0.00 10 0.828 P35575 G122D Disease 0.754 0.720 0.02 33 0.811 P35575 G184E Disease 0.946 0.961 0.00 63 0.962 P35575 G184V Disease 0.955 0.958 0.00 55 0.967 P35575 G188D Disease 0.944 0.961 0.00 56 0.961 P35575 G188R Disease 0.958 0.969 0.00 58 0.975 P35575 G188S Disease 0.905 0.935 0.00 37 0.911 P35575 G222R Disease 0.713 0.917 0.04 44 0.861 P35575 G266V Disease 0.955 0.855 0.00 2 0.921 P35575 G270R Disease 0.899 0.887 0.00 47 0.903 P35575 G270V Disease 0.828 0.824 0.00 29 0.872 P35575 G270W Disease 0.980 0.834 0.00 43 0.939 P35575 H119L Disease 0.932 0.871 0.00 56 0.948 P35575 H179P Disease 0.950 0.991 0.00 66 0.949 P35575 I341N Disease 0.846 0.570 0.00 42 0.738 P35575 L211P Disease 0.620 0.764 0.11 38 0.654 P35575 L265P Disease 0.736 0.861 0.13 14 0.842 P35575 L345R Disease 0.656 0.440 0.01 54 0.639 P35575 N264K Disease 0.515 0.592 0.02 31 0.724 P35575 P113L Disease 0.924 0.698 0.00 28 0.854 P35575 P178S Disease 0.766 0.872 0.00 54 0.925 P35575 P257L Disease 0.389 0.877 0.00 25 0.612 P35575 R170Q Disease 0.885 0.932 0.00 83 0.957 P35575 R295C Disease 0.864 0.587 0.00 62 0.933 P35575 S298P Disease 0.377 0.486 0.02 21 0.560 P35575 T108I Disease 0.852 0.656 0.01 34 0.733 P35575 T111I Disease 0.420 0.772 0.01 31 0.729 P35575 V166A Disease 0.728 0.805 0.00 34 0.790 P35575 V166G Disease 0.917 0.950 0.00 46 0.916 P35575 V338F Disease 0.744 0.556 0.04 -10 0.681 P35575 W156L Disease 0.382 0.828 0.50 -25 0.565 P35575 W236R Disease 0.959 0.954 0.00 52 0.935 P35575 Y209C Disease 0.875 0.908 0.00 35 0.810 P35579 A95T Disease 0.492 0.682 0.06 24 0.549 P35579 N93K Disease 0.727 0.729 0.01 51 0.886 P35579 S96L Disease 0.721 0.778 0.01 20 0.844 P35579 K373N Disease 0.487 0.693 0.08 -13 0.477 P35579 K910Q Disease 0.313 0.686 0.04 31 0.599 P35579 R702C Disease 0.990 0.948 0.00 62 0.943 P35579 R702H Disease 0.979 0.886 0.00 62 0.915 P35579 R705H Disease 0.726 0.872 0.00 58 0.905 P35579 D1424H Disease 0.564 0.811 0.00 16 0.816 P35579 D1424N Disease 0.332 0.826 0.01 -12 0.623 P35579 D1424Y Disease 0.690 0.934 0.00 25 0.855 P35579 E1841K Disease NA 0.575 0.01 31 0.769 P35579 I1816V Disease NA 0.185 1.00 -28 0.152 P35579 R1165C Disease 0.739 0.850 0.00 43 0.850 P35579 R1165L Disease 0.259 0.680 0.00 25 0.488 P35579 S1114P Disease 0.301 0.416 0.14 22 0.406 P35579 T1155I Disease 0.532 0.549 0.00 10 0.482 P35590 A1104V Polymorphism 0.293 0.049 0.95 -52 0.024 P35609 Q9R Disease NA 0.200 0.22 -14 0.134 P35609 M604V Polymorphism 0.127 0.126 0.93 -8 0.108 P35610 Q526R Polymorphism 0.343 0.089 1.00 -17 0.115 P35611 R6C Polymorphism NA 0.238 0.07 28 0.399 P35611 E376D Polymorphism 0.830 0.820 0.06 22 0.792 P35611 G460W Polymorphism 0.896 0.392 0.04 26 0.630 P35611 Y270N Polymorphism 0.908 0.900 0.02 57 0.948 P35612 S98C Polymorphism 0.611 0.324 0.10 20 0.567 P35612 E335D Polymorphism 0.213 0.548 0.34 -24 0.383 P35612 S663R Polymorphism 0.342 0.386 0.03 3 0.412 P35625 G189C Disease 0.686 0.304 0.01 -9 0.529 P35625 G190C Disease 0.631 0.895 0.00 37 0.850 P35625 S179C Disease 0.497 0.534 0.01 30 0.717 P35625 S204C Disease 0.386 0.167 0.03 12 0.185 P35625 Y191C Disease 0.651 0.436 0.14 28 0.532 P35626 N60S Polymorphism NA 0.325 0.74 9 0.282 P35626 V409M Polymorphism 0.081 0.117 0.14 -46 0.098 P35637 G515C Disease NA 0.173 0.00 37 0.243 P35637 P525L Disease NA 0.193 0.00 2 0.234 P35637 R244C Disease 0.500 0.185 0.04 54 0.189 P35637 R514G Disease NA 0.217 0.00 29 0.175 P35637 R514S Disease NA 0.197 0.00 27 0.201 P35637 R518K Disease NA 0.152 0.00 34 0.230 P35637 R521C Disease NA 0.168 0.00 51 0.271 P35637 R521G Disease NA 0.169 0.00 32 0.249 P35637 R521H Disease NA 0.167 0.00 35 0.145 P35637 R522G Disease NA 0.163 0.00 21 0.252 P35637 R524S Disease NA 0.180 0.00 25 0.257 P35637 R524T Disease NA 0.201 0.00 37 0.259 P35670 G85V Disease NA 0.880 0.00 59 0.897 P35670 N41S Disease NA 0.235 0.09 25 0.376 P35670 A486S Disease 0.102 0.509 0.73 -41 0.131 P35670 A604P Disease 0.631 0.942 0.03 39 0.850 P35670 A756G Disease 0.441 0.240 0.47 7 0.342 P35670 A861T Disease 0.428 0.449 0.14 16 0.469 P35670 A874V Disease 0.586 0.749 0.02 46 0.844 P35670 A971V Disease 0.718 0.781 0.02 29 0.816 P35670 C703Y Disease 0.824 0.733 0.01 24 0.834 P35670 C985Y Disease 0.986 0.917 0.00 64 0.904 P35670 D642H Disease 0.303 0.433 0.11 -5 0.409 P35670 D765G Disease 0.760 0.446 0.01 36 0.667 P35670 D765N Disease 0.714 0.587 0.01 36 0.791 P35670 D918E Disease 0.818 0.856 0.00 35 0.790 P35670 D918N Disease 0.882 0.873 0.00 49 0.878 P35670 G591D Disease 0.966 0.927 0.00 57 0.888 P35670 G626A Disease 0.555 0.832 0.11 58 0.778 P35670 G691R Disease 0.519 0.909 0.03 56 0.859 P35670 G710A Disease 0.756 0.140 1.00 -43 0.117 P35670 G710R Disease 0.901 0.784 0.10 34 0.787 P35670 G710S Disease 0.788 0.351 0.51 -38 0.432 P35670 G710V Disease 0.891 0.462 0.26 -32 0.524 P35670 G711E Disease 0.956 0.903 0.00 72 0.931 P35670 G711R Disease 0.965 0.860 0.00 73 0.918 P35670 G711W Disease 0.988 0.784 0.00 66 0.932 P35670 G869R Disease 0.901 0.930 0.02 56 0.900 P35670 G869V Disease 0.891 0.922 0.01 50 0.896 P35670 G875V Disease 0.778 0.911 0.01 58 0.914 P35670 G891V Disease 0.963 0.902 0.01 64 0.900 P35670 G943C Disease 0.897 0.826 0.00 23 0.819 P35670 G943D Disease 0.450 0.726 0.01 65 0.811 P35670 G943S Disease 0.555 0.669 0.03 14 0.559 P35670 G988R Disease 0.965 0.812 0.00 69 0.904 P35670 H639Y Disease 0.618 0.278 0.04 24 0.565 P35670 I747F Disease 0.656 0.547 0.25 5 0.626 P35670 I857T Disease 0.732 0.600 0.01 53 0.819 P35670 I967F Disease NA 0.470 0.22 17 0.430 P35670 K832R Polymorphism 0.531 0.135 0.69 -5 0.153 P35670 L466V Polymorphism NA 0.193 0.05 -2 0.219 P35670 L492S Disease 0.704 0.577 0.01 45 0.822 P35670 L641S Disease 0.268 0.297 0.73 -13 0.270 P35670 L708P Disease 0.726 0.914 0.01 35 0.879 P35670 L776P Disease 0.906 0.888 0.00 57 0.902 P35670 L776V Polymorphism 0.586 0.643 0.06 16 0.522 P35670 L795F Disease 0.683 0.850 0.01 44 0.792 P35670 L795R Disease 0.876 0.918 0.00 65 0.900 P35670 M645R Disease 0.167 0.500 0.55 -42 0.107 P35670 M665I Disease 0.243 0.825 0.39 -26 0.390 P35670 M769I Disease 0.561 0.360 0.14 -6 0.548 P35670 M769R Disease 0.823 0.786 0.00 47 0.866 P35670 M769V Disease 0.581 0.092 0.24 -3 0.236 P35670 M996T Disease 0.763 0.931 0.01 56 0.637 P35670 P690L Disease 0.637 0.875 0.19 1 0.657 P35670 P760L Disease 0.888 0.479 0.10 43 0.746 P35670 P768H Disease 0.940 0.378 0.04 30 0.654 P35670 P840L Disease 0.888 0.865 0.01 46 0.840 P35670 P992H Disease 0.993 0.910 0.00 62 0.914 P35670 P992L Disease 0.989 0.898 0.00 43 0.881 P35670 Q898R Disease 0.681 0.782 0.40 43 0.553 P35670 R616Q Disease 0.456 0.267 0.23 6 0.347 P35670 R616W Disease 0.908 0.684 0.01 35 0.807 P35670 R778G Disease 0.814 0.589 0.01 33 0.784 P35670 R778L Disease 0.819 0.772 0.02 30 0.641 P35670 R778Q Disease 0.750 0.429 0.04 23 0.647 P35670 R778W Disease 0.954 0.899 0.00 33 0.858 P35670 R919G Disease 0.671 0.390 0.03 29 0.638 P35670 R919W Disease 0.897 0.829 0.01 6 0.819 P35670 R952K Polymorphism 0.175 0.208 1.00 -1 0.159 P35670 R969Q Disease 0.397 0.187 0.59 -16 0.172 P35670 S653Y Disease 0.415 0.500 0.87 15 0.653 P35670 S657R Disease 0.374 0.879 0.00 53 0.800 P35670 S693C Disease 0.780 0.716 0.13 31 0.800 P35670 S721P Disease 0.527 0.817 0.09 46 0.860 P35670 S744P Disease 0.794 0.702 0.00 60 0.903 P35670 S921N Disease 0.596 0.489 0.02 28 0.693 P35670 S975Y Disease 0.821 0.464 0.03 0 0.644 P35670 T737R Disease 0.747 0.723 0.00 53 0.890 P35670 T766M Disease 0.691 0.340 0.01 4 0.599 P35670 T766R Disease 0.696 0.522 0.01 44 0.802 P35670 T933P Disease 0.469 0.606 0.02 28 0.752 P35670 T935M Disease 0.963 0.685 0.00 28 0.796 P35670 T974M Disease 0.564 0.524 0.23 -39 0.531 P35670 T977M Disease 0.792 0.307 0.01 19 0.613 P35670 T991M Disease 0.979 0.882 0.00 51 0.904 P35670 V290L Polymorphism NA 0.813 0.13 36 0.662 P35670 V446L Polymorphism NA 0.108 0.33 8 0.136 P35670 V536A Disease 0.584 0.402 0.31 6 0.524 P35670 V890M Disease 0.646 0.881 0.01 38 0.809 P35670 V949G Disease 0.287 0.536 0.00 22 0.491 P35670 V995A Polymorphism 0.638 0.524 0.01 47 0.816 P35670 Y532H Disease 0.613 0.678 0.11 44 0.631 P35670 Y713C Disease 0.895 0.693 0.16 14 0.842 P35670 Y741C Disease 0.909 0.611 0.01 43 0.828 P35670 A1003T Disease 0.929 0.955 0.00 45 0.857 P35670 A1003V Disease 0.957 0.918 0.00 40 0.849 P35670 A1018V Disease 0.238 0.669 0.38 7 0.331 P35670 A1063V Disease 0.129 0.230 0.38 7 0.229 P35670 A1065P Disease 0.663 0.839 0.15 34 0.763 P35670 A1168S Disease 0.133 0.234 0.74 -25 0.210 P35670 A1183G Disease 0.574 0.714 0.03 9 0.515 P35670 A1183T Disease 0.311 0.909 0.24 31 0.450 P35670 A1278V Disease 0.725 0.917 0.00 51 0.896 P35670 A1328T Disease 0.840 0.785 0.01 32 0.852 P35670 A1358S Disease 0.588 0.723 0.03 19 0.609 P35670 C1104F Disease 0.685 0.593 0.04 55 0.835 P35670 C1104Y Disease 0.736 0.525 0.03 58 0.878 P35670 C1375S Disease NA 0.264 0.56 -6 0.188 P35670 D1164N Disease 0.342 0.285 0.43 0 0.294 P35670 D1222N Disease 0.991 0.867 0.00 60 0.926 P35670 D1222V Disease 0.997 0.919 0.00 60 0.932 P35670 D1222Y Disease 0.997 0.938 0.00 64 0.934 P35670 D1267A Disease 0.974 0.892 0.00 73 0.920 P35670 D1267V Disease 0.990 0.928 0.00 75 0.925 P35670 D1271N Disease 0.991 0.888 0.00 69 0.926 P35670 D1279G Disease 0.522 0.890 0.03 55 0.892 P35670 D1279Y Disease 0.789 0.949 0.00 61 0.798 P35670 D1296N Disease 0.553 0.791 0.06 47 0.720 P35670 E1064A Disease 0.515 0.831 0.00 50 0.863 P35670 E1064K Disease 0.506 0.918 0.00 63 0.903 P35670 E1068G Disease 0.892 0.755 0.02 52 0.885 P35670 E1173G Disease 0.579 0.500 0.61 29 0.542 P35670 E1173K Disease 0.435 0.651 0.22 37 0.597 P35670 F1094L Disease NA 0.835 0.00 60 0.889 P35670 G1000R Disease 0.979 0.930 0.00 72 0.910 P35670 G1035V Disease 0.891 0.876 0.00 51 0.889 P35670 G1061E Disease 0.646 0.865 0.07 58 0.901 P35670 G1089E Disease 0.144 0.359 0.17 37 0.272 P35670 G1089V Disease 0.308 0.208 0.19 34 0.339 P35670 G1099S Disease 0.900 0.925 0.03 64 0.927 P35670 G1101R Disease 0.956 0.916 0.01 75 0.933 P35670 G1111D Disease NA 0.924 0.21 16 0.629 P35670 G1149A Disease 0.440 0.790 0.00 59 0.808 P35670 G1176E Disease 0.872 0.909 0.00 49 0.905 P35670 G1176R Disease 0.904 0.921 0.00 50 0.910 P35670 G1186C Disease 0.811 0.876 0.01 23 0.844 P35670 G1186S Disease 0.376 0.820 0.16 6 0.464 P35670 G1213V Disease 0.784 0.895 0.00 55 0.908 P35670 G1221E Disease 0.994 0.935 0.00 74 0.933 P35670 G1266R Disease 0.999 0.916 0.00 72 0.934 P35670 G1266V Disease 0.999 0.923 0.00 63 0.934 P35670 G1287S Disease 0.977 0.850 0.00 66 0.919 P35670 G1341D Disease 0.871 0.959 0.02 62 0.939 P35670 G1341S Disease 0.794 0.960 0.06 46 0.845 P35670 G1341V Disease 0.895 0.959 0.07 51 0.931 P35670 G1355C Disease 0.726 0.893 0.01 8 0.861 P35670 G1355S Disease 0.365 0.778 0.06 -22 0.493 P35670 H1069Q Disease 0.995 0.920 0.00 66 0.912 P35670 H1207R Polymorphism 0.553 0.285 0.52 -40 0.339 P35670 I1102T Disease 0.657 0.575 0.03 40 0.751 P35670 I1148T Disease 0.735 0.352 0.03 53 0.684 P35670 I1230V Disease 0.264 0.136 0.23 -2 0.231 P35670 I1336T Disease 0.886 0.775 0.00 34 0.849 P35670 K1248N Disease 0.994 0.908 0.00 58 0.931 P35670 L1043P Disease 0.435 0.799 0.07 0 0.695 P35670 L1083F Disease 0.507 0.326 0.13 3 0.531 P35670 L1255I Disease 0.174 0.819 0.00 3 0.427 P35670 L1305P Disease 0.879 0.707 0.14 24 0.812 P35670 L1327V Disease 0.364 0.314 0.20 -7 0.365 P35670 L1368P Disease 0.626 0.860 0.24 13 0.819 P35670 L1373P Disease 0.896 0.925 0.00 68 0.931 P35670 L1373R Disease 0.870 0.905 0.00 70 0.928 P35670 M1169T Disease 0.646 0.249 0.04 24 0.569 P35670 M1169V Disease 0.370 0.239 0.35 4 0.335 P35670 M1359I Disease 0.443 0.886 0.00 55 0.900 P35670 N1270S Disease 0.992 0.913 0.00 56 0.924 P35670 P1052L Disease 0.216 0.531 0.09 10 0.326 P35670 P1098R Disease 0.738 0.785 0.35 65 0.903 P35670 P1245S Polymorphism 0.995 0.884 0.00 46 0.900 P35670 P1273L Disease 0.892 0.928 0.00 34 0.856 P35670 P1352S Disease 0.684 0.876 0.00 49 0.890 P35670 P1379S Disease 0.792 0.841 0.03 32 0.792 P35670 Q1004P Disease 0.519 0.951 0.12 34 0.856 P35670 Q1095P Disease 0.542 0.884 0.18 32 0.861 P35670 Q1142H Disease 0.518 0.231 0.02 -26 0.550 P35670 Q1256R Disease 0.337 0.784 0.24 32 0.545 P35670 R1038K Disease 0.280 0.364 0.96 -38 0.182 P35670 R1041P Disease 0.647 0.939 0.27 17 0.857 P35670 R1041W Disease 0.866 0.857 0.02 34 0.869 P35670 R1151H Disease 0.630 0.695 0.04 36 0.598 P35670 R1228T Disease 0.362 0.344 0.10 0 0.389 P35670 R1322P Disease 0.774 0.933 0.01 59 0.925 P35670 S1310R Disease 0.690 0.623 0.01 40 0.802 P35670 S1363F Disease 0.972 0.892 0.00 54 0.935 P35670 T1029I Disease 0.996 0.851 0.00 58 0.921 P35670 T1031I Disease 0.999 0.810 0.00 55 0.924 P35670 T1033A Disease 0.978 0.773 0.00 57 0.907 P35670 T1033S Disease 0.982 0.758 0.00 53 0.904 P35670 T1220M Disease 0.891 0.903 0.00 66 0.913 P35670 T1232P Disease 0.410 0.822 0.08 -2 0.665 P35670 T1434M Disease NA 0.114 0.20 31 0.160 P35670 V1106D Disease 0.754 0.819 0.01 59 0.908 P35670 V1106I Disease 0.224 0.289 0.19 13 0.338 P35670 V1109M Polymorphism NA 0.258 0.08 17 0.359 P35670 V1146M Disease 0.671 0.478 0.02 42 0.712 P35670 V1216M Disease 0.772 0.803 0.03 22 0.827 P35670 V1239G Disease 0.815 0.860 0.00 66 0.913 P35670 V1252I Disease 0.108 0.295 0.68 -13 0.214 P35670 V1262F Disease 0.784 0.967 0.00 52 0.911 P35670 V1297I Polymorphism 0.144 0.108 0.49 -55 0.136 P35670 W1153C Disease 0.825 0.810 0.06 66 0.922 P35670 W1153R Disease 0.687 0.663 0.24 66 0.826 P35670 W1353R Disease 0.904 0.838 0.03 57 0.924 P35670 Y1331S Disease 0.979 0.709 0.00 47 0.884 P35680 G76C Disease 0.795 0.328 0.02 20 0.589 P35680 S36F Disease 0.638 0.123 0.01 6 0.221 P35680 V61G Disease 0.583 0.535 0.15 2 0.422 P35680 A241T Disease 0.637 0.567 0.43 51 0.769 P35680 E260D Disease 0.572 0.481 0.19 35 0.618 P35680 G285D Disease 0.858 0.905 0.00 56 0.937 P35680 G370S Disease 0.121 0.105 0.82 0 0.099 P35680 H153N Disease 0.828 0.564 0.30 29 0.765 P35680 K156E Disease 0.683 0.586 0.17 38 0.754 P35680 K164Q Disease 0.675 0.748 0.02 40 0.849 P35680 Q136E Disease 0.663 0.850 0.06 37 0.858 P35680 R112P Disease 0.670 0.695 0.05 32 0.839 P35680 R165H Disease 0.847 0.832 0.01 42 0.878 P35680 R235Q Disease 0.736 0.483 0.00 70 0.903 P35680 R276G Disease 0.804 0.830 0.01 57 0.927 P35680 R276Q Disease 0.736 0.752 0.02 60 0.899 P35680 R295C Disease 0.934 0.961 0.00 61 0.954 P35680 R295H Disease 0.847 0.896 0.00 54 0.934 P35680 R295P Disease 0.866 0.990 0.00 56 0.938 P35680 S148L Disease 0.790 0.784 0.00 39 0.851 P35680 S148W Disease 0.955 0.888 0.00 52 0.957 P35680 S151P Disease 0.784 0.768 0.01 65 0.910 P35680 S465R Disease 0.492 0.611 0.01 52 0.723 P35680 V110G Disease 0.632 0.599 0.00 19 0.713 P35713 W95R Disease 0.999 0.940 0.00 70 0.953 P35713 A104P Disease 0.990 0.925 0.00 53 0.949 P35749 R1758Q Disease NA 0.451 0.14 2 0.396 P35749 V1289A Polymorphism NA 0.132 0.63 -16 0.175 P35754 D47Y Polymorphism 0.676 0.644 0.00 42 0.803 P35789 D93Y Polymorphism 0.618 0.440 0.23 41 0.677 P35790 L422Q Polymorphism 0.845 0.862 0.11 30 0.868 P35790 S220G Polymorphism 0.378 0.509 0.35 11 0.442 P35869 M786V Polymorphism 0.329 0.225 0.06 57 0.135 P35869 P517S Polymorphism 0.229 0.222 0.90 -33 0.198 P35908 E465D Disease 0.631 0.340 0.10 -29 0.542 P35908 E465K Disease 0.889 0.627 0.00 25 0.801 P35908 E476K Disease 0.876 0.940 0.00 47 0.887 P35908 E476V Disease 0.973 0.866 0.00 45 0.908 P35908 E487D Disease 0.799 0.632 0.00 38 0.847 P35908 E487K Disease 0.895 0.807 0.00 44 0.850 P35908 E488K Disease 0.969 0.513 0.00 46 0.886 P35908 G219D Polymorphism 0.159 0.655 0.54 8 0.193 P35908 I182N Disease 0.977 0.772 0.00 33 0.895 P35908 I477N Disease 0.997 0.947 0.00 40 0.913 P35908 L484P Disease 0.983 0.914 0.00 55 0.940 P35908 N186D Disease 0.793 0.844 0.00 40 0.856 P35908 N186K Disease 0.927 0.880 0.00 40 0.894 P35908 N186Y Disease 0.976 0.906 0.00 46 0.916 P35908 Q181P Disease 0.938 0.878 0.00 57 0.933 P35908 T479P Disease 0.952 0.907 0.00 45 0.911 P35913 R74C Disease NA 0.825 0.05 22 0.807 P35913 E654D Polymorphism 0.404 0.632 0.17 -20 0.493 P35913 G576D Disease 0.744 0.776 0.24 56 0.779 P35913 H258N Disease NA 0.582 0.12 52 0.699 P35913 H557Y Disease 0.998 0.920 0.00 76 0.953 P35913 I535N Disease 0.709 0.870 0.00 48 0.886 P35913 L228H Disease NA 0.694 0.23 43 0.798 P35913 L527P Disease 0.764 0.903 0.00 51 0.899 P35913 L699R Disease NA 0.802 0.65 48 0.787 P35913 L854R Disease 0.492 0.338 0.00 -47 0.503 P35913 R552Q Disease 0.953 0.857 0.00 38 0.868 P35913 Y212H Polymorphism NA 0.780 0.27 67 0.887 P35913 Y219H Disease NA 0.426 0.28 26 0.215 P35914 D42E Disease NA 0.872 0.00 66 0.889 P35914 D42G Disease NA 0.892 0.00 65 0.918 P35914 D42H Disease NA 0.889 0.00 75 0.917 P35914 E37K Disease NA 0.951 0.02 70 0.930 P35914 K48N Disease NA 0.570 0.10 0 0.422 P35914 R41Q Disease NA 0.919 0.00 70 0.926 P35914 S75R Disease NA 0.929 0.08 71 0.926 P35914 V70L Disease NA 0.633 0.20 -19 0.417 P35914 C174Y Disease 0.892 0.938 0.01 64 0.924 P35914 D204N Disease 0.551 0.810 0.00 71 0.904 P35914 E279K Disease 0.572 0.949 0.00 60 0.919 P35914 F192S Disease 0.446 0.796 0.10 10 0.764 P35914 G203E Disease 0.891 0.817 0.09 60 0.913 P35914 H233R Disease 0.830 0.940 0.00 81 0.914 P35914 I200F Disease 0.657 0.890 0.01 36 0.705 P35914 L263P Disease 0.917 0.922 0.01 50 0.921 P35914 S142F Disease 0.807 0.815 0.00 41 0.855 P35914 S201Y Disease 0.912 0.870 0.02 44 0.862 P35916 G857R Disease 0.968 0.900 0.00 68 0.942 P35916 H868Y Polymorphism 0.263 0.352 0.03 -2 0.248 P35916 H890Q Polymorphism 0.071 0.231 0.20 -2 0.146 P35916 N149D Polymorphism NA 0.151 0.72 -8 0.207 P35916 N527S Polymorphism 0.336 0.241 0.67 -26 0.233 P35916 P954S Disease NA 0.507 0.51 -20 0.433 P35916 T494A Polymorphism 0.241 0.069 0.71 9 0.140 P35916 D1049N Polymorphism 0.377 0.139 1.00 -53 0.084 P35916 H1035R Disease 0.774 0.865 0.00 66 0.919 P35916 L1044P Disease 0.966 0.950 0.00 46 0.922 P35916 P1114L Disease 0.966 0.943 0.00 49 0.930 P35916 P1137S Disease 0.997 0.735 0.00 54 0.935 P35916 R1031Q Polymorphism 0.735 0.521 0.00 12 0.694 P35916 R1041P Disease 0.993 0.950 0.00 61 0.943 P35916 R1075Q Polymorphism 0.406 0.677 0.00 54 0.743 P35916 R1146H Polymorphism 0.072 0.255 0.20 -27 0.197 P35968 C482R Polymorphism 0.602 0.779 0.40 49 0.678 P35968 D814N Polymorphism NA 0.457 0.01 24 0.426 P35968 G539R Polymorphism 0.604 0.193 0.55 20 0.261 P35968 L462V Polymorphism 0.241 0.112 0.32 -26 0.211 P35968 Q472H Polymorphism 0.162 0.123 0.09 9 0.212 P35968 T689M Polymorphism 0.236 0.099 0.10 6 0.245 P35968 V136M Polymorphism NA 0.454 0.01 39 0.538 P35968 V297I Polymorphism 0.256 0.470 0.20 28 0.395 P35968 V848E Polymorphism 0.667 0.881 0.00 72 0.917 P35968 V952I Polymorphism NA 0.084 0.35 -33 0.174 P35968 A1065T Polymorphism 0.216 0.289 0.24 4 0.332 P36021 A150V Disease 0.438 0.867 1.00 -4 0.419 P36021 G490R Disease 0.841 0.943 0.03 51 0.929 P36021 I323L Polymorphism 0.293 0.619 0.31 4 0.367 P36021 L360W Disease 0.819 0.838 0.00 36 0.857 P36021 L397P Disease 0.760 0.741 0.22 24 0.796 P36021 L438P Disease 0.822 0.917 0.02 45 0.875 P36021 L494P Disease 0.847 0.949 0.00 49 0.907 P36021 S120F Disease 0.532 0.969 0.00 56 0.924 P36021 V161M Disease 0.503 0.700 0.05 -1 0.484 P36222 I311T Polymorphism 0.236 0.166 0.10 -11 0.233 P36269 I475V Polymorphism 0.542 0.261 0.00 -2 0.480 P36404 V141A Polymorphism 0.135 0.154 0.64 -38 0.103 P36406 D480N Polymorphism 0.993 0.865 0.00 59 0.950 P36507 F57C Disease NA 0.747 0.06 30 0.636 P36508 T48M Polymorphism NA 0.091 0.12 14 0.101 P36508 R403Q Polymorphism NA 0.091 0.99 32 0.125 P36551 E201K Disease NA 0.951 0.00 63 0.940 P36551 G189S Disease NA 0.878 0.00 41 0.869 P36551 G197W Disease NA 0.948 0.00 63 0.938 P36551 G279R Disease 0.743 0.921 0.00 72 0.936 P36551 G280R Disease 0.234 0.919 0.00 65 0.925 P36551 H295D Disease 0.262 0.753 0.04 38 0.534 P36551 K404E Disease 0.264 0.442 0.34 13 0.451 P36551 L214R Disease NA 0.719 0.63 4 0.481 P36551 P249R Disease 0.452 0.790 0.00 57 0.878 P36551 P249S Disease 0.396 0.722 0.00 37 0.632 P36551 R328C Disease 0.876 0.909 0.00 68 0.941 P36551 R331W Disease 0.769 0.691 0.02 -3 0.696 P36551 R447C Disease 0.466 0.665 0.01 15 0.713 P36551 S208F Disease NA 0.875 0.00 58 0.907 P36551 V135A Disease NA 0.259 0.20 9 0.336 P36551 V294I Polymorphism 0.211 0.073 0.38 -47 0.152 P36551 W427R Disease 0.512 0.868 0.00 69 0.911 P36575 L44F Polymorphism NA 0.676 0.03 15 0.562 P36639 V124M Polymorphism 0.796 0.542 0.33 46 0.716 P36776 E87D Polymorphism NA 0.124 0.03 -7 0.074 P36871 K68M Polymorphism 0.500 0.564 0.11 15 0.695 P36871 V501I Polymorphism NA 0.212 1.00 -8 0.228 P36871 Y420H Polymorphism NA 0.737 0.00 65 0.769 P36873 F152S Polymorphism 0.867 0.666 0.01 42 0.829 P36888 D7G Polymorphism NA 0.129 NA 21 0.019 P36888 D358V Polymorphism 0.416 0.274 0.07 17 0.366 P36888 V194M Polymorphism NA 0.061 0.18 28 0.127 P36888 V557I Polymorphism 0.140 0.149 1.00 -44 0.106 P36894 P2T Polymorphism NA 0.104 1.00 -40 0.016 P36894 C82Y Disease NA 0.983 0.00 68 0.939 P36894 Y62D Disease NA 0.530 0.18 49 0.745 P36894 A338D Disease 0.824 0.709 0.09 37 0.851 P36894 C124R Disease NA 0.981 0.00 66 0.940 P36894 C130R Disease NA 0.979 0.00 76 0.941 P36894 C376Y Disease 0.973 0.880 0.00 51 0.932 P36894 M470T Disease 0.960 0.299 0.00 48 0.771 P36894 R443C Disease 0.994 0.944 0.00 59 0.950 P36894 V450M Polymorphism 0.837 0.451 0.06 8 0.659 P36896 F146L Polymorphism NA 0.548 0.65 -31 0.386 P36896 L408V Polymorphism 0.951 0.257 0.01 1 0.619 P36897 D400G Disease 0.977 0.926 0.00 64 0.940 P36897 I139V Polymorphism NA 0.350 0.74 -58 0.229 P36897 K232E Disease 0.979 0.900 0.00 62 0.942 P36897 M318R Disease 0.413 0.631 0.21 24 0.747 P36897 R487P Disease 0.930 0.826 0.09 57 0.924 P36897 R487Q Disease 0.813 0.467 0.26 4 0.625 P36897 R487W Disease 0.973 0.655 0.02 33 0.846 P36897 S241L Disease 0.867 0.517 0.00 27 0.782 P36897 T200I Disease 0.635 0.734 0.01 17 0.672 P36897 V153I Polymorphism NA 0.142 0.41 -7 0.174 P36897 Y291C Polymorphism 0.987 0.699 0.00 47 0.910 P36952 S176P Polymorphism 0.185 0.561 0.31 -34 0.195 P36956 N306S Polymorphism 0.123 0.371 0.06 -20 0.259 P36956 R746H Polymorphism 0.635 0.430 0.01 53 0.652 P36956 S834L Polymorphism 0.228 0.543 0.00 24 0.488 P36956 V417M Polymorphism 0.085 0.073 0.25 -6 0.075 P36956 V580M Polymorphism 0.676 0.490 0.00 47 0.735 P36956 T1000A Polymorphism NA 0.149 0.64 -17 0.098 P36957 P384T Polymorphism 0.718 0.895 0.00 56 0.902 P36959 A234T Polymorphism 0.293 0.904 0.04 24 0.733 P36959 F256I Polymorphism 0.391 0.697 0.78 -48 0.366 P37023 C51Y Disease NA 0.834 0.76 59 0.721 P37023 C77W Disease NA 0.910 0.11 67 0.919 P37023 G48R Disease NA 0.223 0.04 37 0.398 P37023 N96D Disease NA 0.920 0.02 56 0.902 P37023 R67Q Disease NA 0.176 0.42 29 0.220 P37023 R67W Disease NA 0.551 0.02 31 0.744 P37023 W50C Disease NA 0.332 0.18 54 0.539 P37023 A306P Disease 0.552 0.827 0.10 47 0.867 P37023 A347P Disease 0.825 0.916 0.01 45 0.896 P37023 A482V Disease 0.708 0.264 0.07 27 0.604 P37023 C344Y Disease 0.881 0.803 0.00 49 0.909 P37023 D179A Disease 0.189 0.251 0.26 14 0.271 P37023 D397G Disease 0.977 0.890 0.00 69 0.931 P37023 E215K Disease 0.665 0.580 0.19 17 0.728 P37023 E379K Disease 0.983 0.955 0.00 75 0.942 P37023 E407D Disease 0.962 0.895 0.00 62 0.931 P37023 F425L Disease 0.560 0.445 0.01 35 0.603 P37023 F425V Disease 0.702 0.306 0.01 51 0.643 P37023 G211D Disease 0.832 0.904 0.00 84 0.918 P37023 G223R Disease 0.783 0.926 0.00 64 0.932 P37023 H314Y Disease 0.981 0.961 0.00 57 0.941 P37023 I245N Polymorphism 0.924 0.764 0.00 37 0.865 P37023 I398N Disease 0.906 0.773 0.00 38 0.871 P37023 K229R Disease 0.949 0.782 0.00 45 0.902 P37023 K487T Disease 0.866 0.351 0.11 26 0.627 P37023 L285F Disease 0.960 0.774 0.01 60 0.924 P37023 L337P Disease 0.936 0.907 0.00 49 0.919 P37023 M376R Disease 0.885 0.940 0.00 66 0.932 P37023 M376V Disease 0.557 0.849 0.12 51 0.790 P37023 P378L Disease 0.988 0.881 0.00 47 0.919 P37023 P424T Disease 0.923 0.612 0.00 47 0.867 P37023 R374Q Disease 0.983 0.640 0.11 47 0.941 P37023 R374W Disease 0.996 0.889 0.02 54 0.940 P37023 R411P Disease 0.989 0.926 0.09 63 0.948 P37023 R411Q Disease 0.983 0.762 0.04 56 0.934 P37023 R411W Disease 0.996 0.860 0.01 61 0.942 P37023 R479L Disease 0.988 0.847 0.00 67 0.948 P37023 R484W Disease 0.934 0.725 0.01 36 0.849 P37023 S333I Disease 0.879 0.860 0.00 50 0.912 P37023 W399S Disease 0.656 0.605 0.00 47 0.821 P37058 A56T Disease 0.893 0.916 0.01 53 0.914 P37058 R80Q Disease 0.865 0.912 0.07 59 0.913 P37058 R80W Disease 0.990 0.967 0.00 64 0.943 P37058 S65L Disease 0.746 0.886 0.00 5 0.868 P37058 A203V Disease 0.688 0.811 0.55 19 0.524 P37058 C268Y Disease NA 0.509 1.00 -19 0.368 P37058 E215D Disease 0.731 0.837 0.06 43 0.671 P37058 F208I Disease 0.897 0.791 0.02 55 0.911 P37058 M235V Disease 0.826 0.651 0.18 55 0.875 P37058 N130S Disease 0.897 0.906 0.11 59 0.809 P37058 P282L Disease NA 0.875 0.00 18 0.719 P37058 Q176P Disease 0.411 0.789 0.19 8 0.579 P37058 S232L Disease 0.605 0.413 0.10 5 0.584 P37058 V205E Disease 0.969 0.831 0.00 64 0.928 P37059 A121T Polymorphism 0.547 0.598 0.05 -5 0.505 P37088 G327C Disease 0.996 0.885 0.00 47 0.907 P37088 P402H Polymorphism NA 0.616 0.01 19 0.738 P37088 S562L Disease 0.998 0.880 0.00 47 0.899 P37088 T663A Polymorphism NA 0.061 1.00 -27 0.024 P37088 W493R Polymorphism 0.976 0.850 0.00 71 0.935 P37108 P124A Polymorphism 0.152 0.353 1.00 38 0.137 P37108 T130A Polymorphism 0.029 0.201 0.00 25 0.131 P37173 M36V Polymorphism NA 0.128 0.59 0 0.037 P37173 A355P Disease 0.458 0.920 0.01 59 0.913 P37173 E526Q Disease 0.818 0.325 0.15 22 0.582 P37173 G357W Disease 0.996 0.843 0.00 54 0.941 P37173 L308P Disease 0.692 0.874 0.00 47 0.889 P37173 M373I Polymorphism 0.056 0.206 0.02 -29 0.136 P37173 R460C Disease 0.995 0.803 0.00 57 0.937 P37173 R460H Disease 0.990 0.373 0.00 63 0.980 P37173 R528C Disease 0.995 0.911 0.00 73 0.955 P37173 R528H Disease 0.990 0.843 0.00 69 0.949 P37173 R537C Disease 0.979 0.837 0.07 52 0.928 P37173 S449F Disease 0.644 0.902 0.00 55 0.907 P37173 T315M Disease 0.528 0.136 0.01 -2 0.340 P37173 V191I Polymorphism NA 0.119 0.39 -23 0.158 P37173 V439A Polymorphism 0.144 0.250 0.23 13 0.262 P37173 Y336N Disease 0.474 0.680 0.00 19 0.742 P37198 A233S Polymorphism NA 0.089 0.97 -24 0.082 P37198 G139S Polymorphism NA 0.248 0.63 16 0.225 P37198 Q391P Disease 0.706 0.763 0.16 36 0.850 P37198 S283T Polymorphism 0.221 0.105 0.82 -26 0.082 P37231 P12A Polymorphism NA 0.199 0.06 22 0.049 P37231 P40A Polymorphism NA 0.296 0.08 10 0.187 P37231 F388L Disease 0.245 0.524 0.23 22 0.428 P37231 P113Q Disease 0.236 0.541 0.11 8 0.428 P37231 R425C Disease 0.939 0.968 0.12 60 0.948 P37268 L392P Polymorphism 0.458 0.673 0.03 -5 0.544 P37275 G90R Polymorphism NA 0.092 0.46 39 0.075 P37287 D40H Disease NA 0.914 0.05 67 0.836 P37287 G48A Disease 0.893 0.918 0.02 66 0.944 P37287 G48D Disease 0.947 0.956 0.01 79 0.953 P37287 G48V Disease 0.958 0.954 0.00 70 0.957 P37287 R19W Disease NA 0.421 0.04 51 0.177 P37287 G239R Disease 0.406 0.845 0.00 50 0.739 P37287 H128R Disease 0.467 0.812 0.00 68 0.906 P37287 N297D Disease 0.207 0.224 0.25 -34 0.165 P37287 S155F Disease 0.858 0.774 0.00 29 0.848 P37288 G6S Polymorphism NA 0.186 0.22 2 0.127 P37840 A30P Disease 0.786 0.805 0.00 27 0.834 P37840 A53T Disease 0.110 0.065 1.00 -69 0.057 P37840 E46K Disease 0.363 0.509 0.02 1 0.497 P38117 D128N Disease 0.916 0.839 0.00 60 0.920 P38117 R164Q Disease 0.749 0.833 0.12 48 0.793 P38398 C61G Disease 0.457 0.678 0.00 53 0.757 P38398 C64G Disease 0.650 0.657 0.00 54 0.840 P38398 C64Y Polymorphism 0.819 0.677 0.00 63 0.933 P38398 E10K Disease 0.230 0.209 0.00 20 0.261 P38398 E23K Disease 0.377 0.398 0.01 12 0.494 P38398 L22S Disease 0.716 0.724 0.00 37 0.842 P38398 R71K Disease 0.405 0.346 0.02 11 0.483 P38398 D693N Polymorphism 0.203 0.334 0.04 20 0.247 P38398 D749Y Disease 0.798 0.976 0.00 39 0.880 P38398 E227K Disease 0.522 0.189 0.00 26 0.198 P38398 F461L Disease 0.607 0.923 0.00 58 0.913 P38398 F989S Polymorphism 0.223 0.173 0.47 10 0.144 P38398 G275S Polymorphism 0.431 0.808 0.00 21 0.616 P38398 G552V Disease 0.382 0.841 0.01 34 0.727 P38398 G960D Disease 0.219 0.937 0.00 25 0.505 P38398 H239R Polymorphism 0.318 0.255 0.00 46 0.258 P38398 H835Y Disease 0.427 0.740 0.01 -5 0.566 P38398 H888Y Disease 0.493 0.609 0.00 46 0.609 P38398 I379M Polymorphism 0.605 0.941 0.00 35 0.862 P38398 I925L Polymorphism 0.177 0.251 0.04 16 0.270 P38398 K820E Polymorphism 0.218 0.928 0.19 20 0.484 P38398 L892S Disease 0.168 0.604 0.39 20 0.276 P38398 N656I Polymorphism 0.563 0.421 0.00 17 0.637 P38398 N723D Polymorphism 0.281 0.473 0.00 15 0.427 P38398 P346S Disease 0.087 0.478 0.75 -31 0.183 P38398 P871L Polymorphism 0.430 0.079 1.00 -1 0.036 P38398 Q356R Polymorphism 0.252 0.684 0.03 31 0.678 P38398 R841W Disease 0.754 0.593 0.00 24 0.746 P38398 R866Q Disease 0.752 0.939 0.00 67 0.949 P38398 S153R Polymorphism 0.194 0.171 0.02 33 0.246 P38398 T826K Disease 0.446 0.911 0.00 44 0.848 P38398 V271M Disease 0.494 0.437 0.00 -2 0.307 P38398 V772A Polymorphism 0.322 0.820 0.00 41 0.733 P38398 Y465D Disease 0.895 0.937 0.00 63 0.952 P38398 A1641P Disease 0.503 0.132 0.00 -22 0.156 P38398 A1708E Disease 0.797 0.711 0.00 48 0.863 P38398 C1697R Disease 0.895 0.878 0.00 51 0.929 P38398 D1692N Disease 0.698 0.553 0.00 33 0.704 P38398 E1038G Polymorphism 0.374 0.810 0.00 40 0.690 P38398 E1060A Polymorphism 0.320 0.739 0.00 59 0.822 P38398 E1210G Disease 0.516 0.537 0.00 36 0.540 P38398 E1250K Polymorphism 0.138 0.127 0.12 48 0.107 P38398 F1226L Disease 0.338 0.345 0.10 42 0.586 P38398 F1662C Polymorphism 0.451 0.139 0.02 42 0.310 P38398 K1183R Polymorphism 0.102 0.104 1.00 -47 0.111 P38398 K1207N Disease 0.284 0.317 0.01 28 0.450 P38398 K1406N Polymorphism 0.650 0.366 0.00 29 0.615 P38398 L1786P Disease 0.630 0.727 0.00 44 0.821 P38398 M1008I Polymorphism 0.076 0.172 0.04 5 0.091 P38398 M1411T Disease 0.745 0.510 0.00 26 0.789 P38398 M1652I Polymorphism 0.152 0.143 0.00 34 0.152 P38398 M1775R Disease 0.799 0.592 0.01 38 0.763 P38398 N1236K Polymorphism 0.150 0.265 0.17 26 0.177 P38398 P1150S Disease 0.614 0.880 0.00 46 0.873 P38398 P1637L Polymorphism 0.359 0.306 0.00 -3 0.414 P38398 P1749R Disease 0.864 0.437 0.10 41 0.666 P38398 P1776S Disease 0.350 0.207 0.00 24 0.249 P38398 P1812S Disease 0.781 0.292 0.00 27 0.418 P38398 Q1200H Disease 0.454 0.604 0.00 46 0.615 P38398 R1204I Disease 0.676 0.830 0.00 58 0.837 P38398 R1243G Disease 0.174 0.272 0.51 34 0.185 P38398 R1347G Polymorphism 0.411 0.577 0.01 21 0.417 P38398 R1443G Polymorphism 0.214 0.173 0.12 12 0.174 P38398 R1443Q Polymorphism 0.107 0.122 0.37 16 0.084 P38398 R1699W Disease 0.951 0.778 0.00 62 0.940 P38398 S1040N Polymorphism 0.613 0.650 0.01 27 0.542 P38398 S1139I Disease 0.539 0.668 0.00 42 0.680 P38398 S1140G Polymorphism 0.182 0.405 0.36 1 0.220 P38398 S1187I Disease 0.444 0.390 0.00 38 0.554 P38398 S1217Y Disease 0.687 0.412 0.00 31 0.637 P38398 S1297P Disease 0.723 0.500 0.00 56 0.854 P38398 S1431P Polymorphism 0.553 0.246 0.01 -26 0.553 P38398 S1512I Polymorphism 0.555 0.429 0.00 29 0.605 P38398 S1613G Polymorphism 0.194 0.129 0.00 20 0.162 P38398 T1025I Disease 0.554 0.736 0.11 43 0.717 P38398 T1620A Polymorphism 0.050 0.110 1.00 -23 0.062 P38398 V1047A Disease 0.284 0.249 0.00 6 0.308 P38398 V1665M Polymorphism 0.748 0.461 0.00 42 0.482 P38398 V1713G Polymorphism 0.849 0.511 0.00 40 0.770 P38435 F299S Disease 0.806 0.938 NA 40 0.860 P38435 G558R Disease 0.690 0.809 NA 48 0.849 P38435 L394R Disease 0.542 0.887 NA 54 0.890 P38435 R325Q Polymorphism 0.094 0.066 NA -8 0.096 P38435 R476C Disease 0.886 0.885 NA 57 0.936 P38435 R476H Disease 0.748 0.824 NA 46 0.803 P38435 R485P Disease 0.491 0.706 NA 17 0.716 P38435 W493S Disease 0.807 0.928 NA 46 0.869 P38435 W501S Disease 0.596 0.935 NA 49 0.809 P38484 T168N Disease 0.155 0.244 0.45 27 0.278 P38567 V47A Polymorphism 0.208 0.295 0.32 -6 0.288 P38570 D360E Polymorphism 0.309 0.610 1.00 36 0.441 P38570 Q892H Polymorphism 0.388 0.235 0.10 25 0.386 P38570 R482Q Polymorphism 0.115 0.873 0.00 44 0.338 P38570 R950W Polymorphism 0.545 0.298 0.03 28 0.566 P38570 C1041S Polymorphism 0.175 0.149 0.86 27 0.132 P38570 V1019A Polymorphism 0.097 0.134 0.11 35 0.173 P38571 T16P Polymorphism NA 0.396 0.28 17 0.424 P38571 V29L Polymorphism NA 0.196 0.35 6 0.295 P38571 F228S Polymorphism 0.874 0.672 0.12 18 0.838 P38571 H129P Disease 0.957 0.919 0.01 54 0.929 P38571 H129R Disease 0.873 0.908 0.01 51 0.894 P38571 L200P Disease 0.994 0.932 0.00 53 0.941 P38646 Q74R Polymorphism 0.192 0.638 0.23 -3 0.527 P38935 A75T Polymorphism NA 0.147 0.19 -50 0.180 P38935 L17P Disease NA 0.953 0.00 59 0.923 P38935 C241R Disease 0.462 0.959 0.01 75 0.934 P38935 D565N Disease 0.971 0.887 0.01 50 0.932 P38935 D974E Disease NA 0.269 0.00 8 0.386 P38935 E334K Disease 0.112 0.718 0.62 51 0.279 P38935 E382K Disease 0.521 0.889 0.01 64 0.916 P38935 E514K Disease 0.995 0.943 0.00 73 0.927 P38935 E928K Polymorphism NA 0.524 0.00 52 0.729 P38935 G586C Disease 0.714 0.717 0.17 3 0.744 P38935 H213R Disease 0.315 0.680 0.15 63 0.852 P38935 H445P Disease 0.672 0.892 0.01 55 0.794 P38935 I275V Polymorphism 0.162 0.109 1.00 -33 0.097 P38935 L192P Disease 0.896 0.909 0.00 1 0.897 P38935 L251P Disease 0.825 0.929 0.00 44 0.897 P38935 L361P Disease NA 0.777 0.01 36 0.678 P38935 L364P Disease 0.839 0.860 0.04 36 0.861 P38935 L426P Disease 0.763 0.943 0.00 57 0.930 P38935 L472P Disease 0.695 0.802 0.05 47 0.827 P38935 L577P Disease 0.809 0.924 0.00 38 0.878 P38935 N583I Disease 0.901 0.925 0.01 54 0.933 P38935 P216L Disease 0.656 0.817 0.00 54 0.905 P38935 P557A Polymorphism 0.140 0.113 0.81 15 0.199 P38935 Q196R Disease 0.912 0.821 0.00 44 0.900 P38935 R581S Disease 0.949 0.938 0.00 65 0.938 P38935 R603C Disease 0.999 0.901 0.00 77 0.944 P38935 R603H Disease 0.999 0.835 0.00 77 0.940 P38935 R637C Disease 0.445 0.924 0.18 50 0.830 P38935 T221A Disease 0.559 0.698 0.01 65 0.877 P38935 T493I Disease 0.484 0.523 0.33 40 0.526 P38935 T671A Polymorphism 0.039 0.062 0.54 -28 0.043 P38935 T879K Disease NA 0.056 0.13 -14 0.073 P38935 V580I Disease 0.348 0.734 0.00 51 0.819 P38935 W386R Disease 0.723 0.536 0.02 70 0.909 P38936 P4L Polymorphism 0.041 0.067 0.00 14 0.117 P38936 F63L Polymorphism 0.384 0.565 0.36 13 0.416 P38936 S31R Polymorphism 0.092 0.042 0.34 33 0.030 P39019 A17P Disease 0.710 0.803 0.14 -14 0.798 P39019 A57P Disease 0.773 0.953 0.04 46 0.893 P39019 A61E Disease 0.690 0.881 0.05 26 0.868 P39019 F21S Disease 0.765 0.584 0.16 -24 0.719 P39019 L18P Disease 0.724 0.856 0.06 20 0.855 P39019 L18R Disease 0.650 0.754 0.09 20 0.825 P39019 L64P Disease 0.894 0.893 0.00 25 0.892 P39019 P47L Disease 0.945 0.903 0.00 17 0.907 P39019 R56Q Disease 0.641 0.944 0.00 52 0.865 P39019 R62Q Disease 0.861 0.932 0.00 46 0.869 P39019 R62W Disease 0.976 0.953 0.00 54 0.949 P39019 S59F Disease 0.909 0.928 0.00 28 0.904 P39019 T55M Disease 0.418 0.238 0.05 -38 0.359 P39019 T76P Disease 0.489 0.703 0.21 28 0.785 P39019 V15F Disease 0.711 0.615 0.01 2 0.752 P39019 W52C Disease 0.973 0.864 0.00 61 0.949 P39019 W52R Disease 0.950 0.917 0.00 65 0.950 P39019 A135T Disease 0.778 0.870 0.00 25 0.837 P39019 G120R Disease 0.949 0.771 0.00 42 0.895 P39019 G127E Disease 0.934 0.911 0.00 61 0.931 P39019 L131P Disease 0.930 0.960 0.00 41 0.904 P39019 L131R Disease 0.916 0.928 0.00 44 0.909 P39019 R101H Disease 0.923 0.909 0.00 22 0.878 P39059 E506D Polymorphism NA 0.068 0.62 -56 0.061 P39059 G446R Polymorphism NA 0.155 0.02 50 0.034 P39059 K989R Polymorphism 0.147 0.447 0.30 1 0.203 P39059 M204V Polymorphism NA 0.129 1.00 22 0.067 P39059 P531R Polymorphism NA 0.245 0.01 9 0.336 P39059 R163H Polymorphism NA 0.665 0.60 -24 0.458 P39059 T391M Polymorphism NA 0.090 0.07 36 0.075 P39060 Q49L Polymorphism NA 0.122 NA 8 0.108 P39060 A288T Polymorphism NA 0.054 NA -4 0.059 P39060 G111R Polymorphism NA 0.321 NA 36 0.254 P39060 P1121R Polymorphism 0.683 0.433 0.32 21 0.564 P39060 Q1195H Polymorphism 0.066 0.272 0.05 11 0.251 P39086 A870V Polymorphism NA 0.372 0.10 -11 0.099 P39086 L902S Polymorphism NA 0.126 0.25 -11 0.094 P39210 R50Q Disease 0.860 0.902 0.00 73 0.868 P39210 R50W Disease 0.996 0.952 0.00 79 0.954 P39210 N166K Disease 0.725 0.818 0.00 63 0.911 P39656 R8G Polymorphism NA 0.289 NA 42 0.089 P39900 G469R Polymorphism 0.653 0.710 0.40 9 0.796 P39905 P21S Disease 0.543 0.272 0.00 22 0.339 P39905 R93W Disease 0.773 0.424 0.00 43 0.480 P39905 D150N Disease 0.163 0.166 0.42 0 0.213 P39905 I211M Disease 0.225 0.172 0.02 5 0.231 P39905 T154S Disease 0.306 0.340 0.53 20 0.261 P40121 R198W Polymorphism 0.883 0.631 0.00 49 0.902 P40123 Y316C Polymorphism 0.392 0.450 0.05 21 0.491 P40145 A80T Polymorphism NA 0.080 0.07 17 0.046 P40189 L8V Polymorphism NA 0.140 0.24 -64 0.182 P40189 I454T Polymorphism 0.522 0.460 0.03 27 0.636 P40200 T280M Disease 0.066 0.051 0.49 -18 0.021 P40225 L14P Polymorphism NA 0.748 0.03 28 0.730 P40227 Y229C Polymorphism 0.883 0.687 0.14 -4 0.795 P40238 A58V Polymorphism NA 0.085 0.06 34 0.115 P40305 S106F Polymorphism 0.337 0.456 0.24 5 0.277 P40313 T150I Polymorphism 0.207 0.223 0.01 26 0.233 P40337 E52K Disease 0.221 0.088 0.00 25 0.161 P40337 E70K Disease 0.398 0.241 0.00 17 0.381 P40337 F76I Disease 0.116 0.391 0.39 28 0.376 P40337 F76L Disease 0.114 0.341 0.37 37 0.390 P40337 F76S Disease 0.438 0.575 0.03 25 0.699 P40337 G93C Disease 0.797 0.572 0.00 49 0.860 P40337 G93D Disease 0.630 0.585 0.00 51 0.818 P40337 G93S Disease 0.503 0.401 0.00 38 0.523 P40337 L63P Disease 0.755 0.327 0.00 33 0.393 P40337 L89P Disease 0.755 0.519 0.00 -13 0.610 P40337 N78H Disease 0.641 0.300 0.00 65 0.777 P40337 N78S Disease 0.389 0.273 0.00 45 0.401 P40337 N78T Disease 0.464 0.333 0.00 52 0.521 P40337 P25L Disease 0.224 0.195 NA 2 0.205 P40337 P81S Disease 0.530 0.205 0.00 -24 0.337 P40337 P86A Disease 0.488 0.168 0.00 -27 0.232 P40337 P86H Disease 0.800 0.314 0.00 7 0.399 P40337 P86L Disease 0.653 0.307 0.00 -14 0.287 P40337 P86R Disease 0.673 0.308 0.00 12 0.383 P40337 P86S Disease 0.530 0.247 0.00 -44 0.371 P40337 Q96P Disease 0.450 0.391 0.18 0 0.483 P40337 R64P Disease 0.672 0.519 0.00 52 0.806 P40337 R79P Disease 0.516 0.793 0.04 29 0.767 P40337 R82P Disease 0.672 0.920 0.00 24 0.845 P40337 S38P Disease 0.391 0.202 0.07 4 0.168 P40337 S65A Disease 0.263 0.181 0.00 32 0.313 P40337 S65L Disease 0.525 0.268 0.00 31 0.493 P40337 S65W Disease 0.872 0.334 0.00 44 0.578 P40337 S68W Disease 0.872 0.372 0.00 31 0.411 P40337 S80I Disease 0.591 0.352 0.00 33 0.404 P40337 S80N Disease 0.481 0.263 0.00 34 0.383 P40337 S80R Disease 0.533 0.407 0.00 35 0.411 P40337 V74G Disease 0.665 0.277 0.01 37 0.386 P40337 V84L Disease 0.251 0.305 0.00 -4 0.348 P40337 W88R Disease 0.694 0.795 0.00 53 0.881 P40337 W88S Disease 0.682 0.693 0.00 46 0.849 P40337 Y98H Disease 0.562 0.403 0.00 37 0.440 P40337 A122I Disease 0.431 0.353 0.00 31 0.487 P40337 A149T Disease 0.314 0.332 0.00 24 0.387 P40337 C162F Disease 0.612 0.543 0.00 37 0.699 P40337 C162R Disease 0.605 0.847 0.00 50 0.875 P40337 C162W Disease 0.838 0.809 0.00 44 0.856 P40337 C162Y Disease 0.669 0.777 0.00 39 0.826 P40337 D121G Disease 0.424 0.817 0.00 41 0.764 P40337 D126Y Disease 0.701 0.522 0.00 30 0.681 P40337 D143E Disease 0.134 0.148 0.09 -2 0.110 P40337 E186K Disease 0.307 0.374 0.00 25 0.497 P40337 F119L Disease 0.227 0.562 0.00 9 0.672 P40337 F119S Disease 0.517 0.845 0.00 8 0.760 P40337 F136C Disease 0.733 0.438 0.00 56 0.510 P40337 F136S Disease 0.517 0.659 0.00 43 0.710 P40337 F136Y Disease 0.234 0.318 0.00 13 0.200 P40337 G114C Disease 0.504 0.454 0.02 37 0.441 P40337 G114R Disease 0.383 0.592 0.03 55 0.702 P40337 G114S Disease 0.098 0.457 0.32 -3 0.205 P40337 H110Y Polymorphism 0.118 0.209 0.00 43 0.292 P40337 H115Q Disease 0.460 0.587 0.00 56 0.707 P40337 H115R Disease 0.393 0.688 0.00 62 0.844 P40337 H115Y Disease 0.414 0.726 0.00 57 0.847 P40337 H191D Disease 0.313 0.134 0.05 12 0.114 P40337 I147T Disease 0.344 0.181 0.02 10 0.129 P40337 I180V Disease 0.123 0.266 0.00 8 0.313 P40337 K159E Disease 0.303 0.378 0.00 12 0.488 P40337 L101G Disease 0.688 0.243 0.00 42 0.378 P40337 L101R Disease 0.666 0.383 0.00 62 0.624 P40337 L116V Disease 0.185 0.187 0.28 -43 0.222 P40337 L118P Disease 0.697 0.770 0.00 7 0.807 P40337 L118R Disease 0.591 0.705 0.00 1 0.734 P40337 L128F Disease 0.377 0.255 0.00 31 0.384 P40337 L158P Disease 0.682 0.727 0.00 58 0.889 P40337 L158V Disease 0.243 0.210 0.00 46 0.365 P40337 L163P Disease 0.682 0.609 0.00 54 0.822 P40337 L178P Disease 0.682 0.666 0.00 29 0.796 P40337 L178Q Disease 0.610 0.539 0.00 31 0.733 P40337 L184P Disease 0.682 0.666 0.00 54 0.826 P40337 L184R Disease 0.572 0.717 0.00 45 0.817 P40337 L188P Disease 0.682 0.500 0.00 29 0.726 P40337 L188Q Disease 0.610 0.396 0.00 18 0.420 P40337 L188V Disease 0.243 0.165 0.00 -22 0.325 P40337 L198Q Disease 0.550 0.249 0.02 -15 0.379 P40337 L198R Disease 0.544 0.354 0.02 8 0.390 P40337 N131K Disease 0.335 0.473 0.00 33 0.552 P40337 N131T Disease 0.384 0.297 0.00 40 0.439 P40337 P154L Disease 0.264 0.685 0.00 29 0.677 P40337 P192S Disease 0.422 0.285 0.00 -13 0.372 P40337 Q145H Disease 0.518 0.282 0.00 34 0.293 P40337 Q164H Disease 0.499 0.348 0.00 28 0.406 P40337 Q164R Disease 0.273 0.356 0.00 2 0.211 P40337 R107G Disease 0.402 0.365 0.25 28 0.491 P40337 R107P Disease 0.493 0.735 0.18 40 0.762 P40337 R161G Disease 0.473 0.484 0.00 36 0.627 P40337 R161P Disease 0.584 0.870 0.00 57 0.892 P40337 R161Q Disease 0.368 0.466 0.00 43 0.588 P40337 R167G Disease 0.473 0.508 0.00 38 0.704 P40337 R167Q Disease 0.368 0.582 0.00 47 0.682 P40337 R167W Disease 0.814 0.740 0.00 47 0.860 P40337 R176W Disease 0.814 0.455 0.00 36 0.512 P40337 R200W Disease 0.814 0.445 0.00 44 0.608 P40337 S111C Disease 0.609 0.220 0.01 32 0.416 P40337 S111N Disease 0.158 0.197 0.33 19 0.233 P40337 S111R Disease 0.358 0.321 0.04 53 0.578 P40337 T105P Disease 0.436 0.268 0.14 -12 0.374 P40337 T157I Disease 0.407 0.448 0.00 25 0.518 P40337 V130L Disease 0.204 0.297 0.00 33 0.367 P40337 V155G Disease 0.489 0.578 0.00 31 0.702 P40337 V155M Disease 0.425 0.208 0.00 -1 0.226 P40337 V166D Disease 0.614 0.441 0.00 48 0.485 P40337 V166F Disease 0.447 0.277 0.00 37 0.383 P40337 V170D Disease 0.614 0.500 0.00 18 0.667 P40337 V170F Disease 0.447 0.356 0.00 23 0.499 P40337 V170G Disease 0.498 0.403 0.00 19 0.505 P40337 W117C Disease 0.788 0.828 0.00 58 0.918 P40337 Y112H Disease 0.449 0.325 0.01 70 0.612 P40337 Y112N Disease 0.613 0.532 0.01 57 0.836 P40337 Y156C Disease 0.627 0.699 0.00 32 0.778 P40337 Y156D Disease 0.571 0.633 0.00 19 0.671 P40337 Y156N Disease 0.490 0.711 0.00 10 0.700 P40337 Y175D Disease 0.593 0.470 0.00 29 0.582 P40692 A21V Disease NA 0.894 0.00 59 0.917 P40692 A29S Disease NA 0.728 0.37 0 0.462 P40692 C77R Disease 0.942 0.678 0.28 58 0.927 P40692 D41G Disease NA 0.896 0.00 65 0.923 P40692 D63E Disease NA 0.879 0.00 54 0.908 P40692 F80V Disease 0.818 0.620 0.09 56 0.899 P40692 G22A Polymorphism NA 0.846 0.01 53 0.893 P40692 G67R Disease NA 0.926 0.00 76 0.937 P40692 G67W Disease NA 0.878 0.00 70 0.921 P40692 I19F Disease NA 0.885 0.00 64 0.921 P40692 I25F Disease NA 0.811 0.00 57 0.894 P40692 I32V Polymorphism NA 0.019 1.00 -12 0.035 P40692 I68N Disease NA 0.876 0.00 62 0.914 P40692 K84E Disease 0.996 0.930 0.00 58 0.949 P40692 M35K Disease NA 0.881 0.00 35 0.883 P40692 M35R Disease NA 0.887 0.00 39 0.886 P40692 N38H Disease NA 0.883 0.00 70 0.923 P40692 N64S Disease NA 0.845 0.01 55 0.896 P40692 P28L Disease NA 0.882 0.14 49 0.888 P40692 Q62K Disease NA 0.786 0.99 17 0.575 P40692 R18C Disease NA 0.830 0.00 51 0.887 P40692 R69K Disease 0.232 0.296 0.91 -18 0.260 P40692 S44F Disease NA 0.834 0.00 39 0.866 P40692 S93G Polymorphism 0.495 0.178 0.38 40 0.299 P40692 A111V Disease 0.757 0.761 0.02 52 0.887 P40692 A128P Disease 0.774 0.834 0.08 42 0.844 P40692 A282G Disease 0.473 0.100 0.37 -4 0.197 P40692 A441T Disease 0.112 0.115 0.81 -37 0.080 P40692 A492T Disease 0.131 0.091 0.67 -6 0.095 P40692 A586P Disease 0.641 0.571 0.02 42 0.781 P40692 A589D Disease 0.466 0.704 0.21 21 0.569 P40692 A623P Disease 0.501 0.623 0.29 18 0.712 P40692 A681T Disease 0.524 0.848 0.01 18 0.833 P40692 D304V Disease 0.998 0.939 0.00 70 0.949 P40692 D485E Disease 0.117 0.138 0.80 -41 0.075 P40692 D485H Disease 0.434 0.097 0.10 26 0.199 P40692 D631A Disease 0.237 0.638 0.76 31 0.628 P40692 E102K Disease 0.943 0.928 0.00 72 0.935 P40692 E234G Disease 0.243 0.527 0.26 32 0.397 P40692 E578G Disease 0.490 0.532 0.14 17 0.716 P40692 G101D Disease 0.998 0.915 0.00 74 0.948 P40692 G244D Disease 0.823 0.938 0.00 68 0.935 P40692 G244V Polymorphism 0.771 0.917 0.01 60 0.826 P40692 H264Y Disease 0.626 0.373 0.03 52 0.661 P40692 H329P Disease 0.433 0.541 0.24 39 0.784 P40692 H718Y Disease 0.781 0.834 0.02 29 0.818 P40692 I107R Disease 0.887 0.850 0.00 75 0.922 P40692 I219V Polymorphism 0.165 0.058 0.77 -19 0.114 P40692 I565F Disease 0.580 0.689 0.03 10 0.595 P40692 K443Q Polymorphism 0.119 0.097 0.27 -25 0.129 P40692 K618A Polymorphism 0.398 0.621 0.03 21 0.738 P40692 K618T Disease 0.444 0.720 0.04 6 0.559 P40692 K751R Disease 0.258 0.610 0.05 -23 0.427 P40692 L155R Disease 0.972 0.932 0.00 73 0.942 P40692 L292P Disease 0.761 0.669 0.20 25 0.779 P40692 L549P Disease 0.843 0.961 0.00 10 0.880 P40692 L550P Disease 0.652 0.806 0.00 4 0.833 P40692 L559R Disease 0.847 0.890 0.00 37 0.874 P40692 L574P Disease 0.784 0.904 0.01 21 0.869 P40692 L582V Disease 0.363 0.395 0.46 22 0.312 P40692 L588P Disease 0.666 0.826 0.00 22 0.840 P40692 L607H Disease 0.771 0.410 0.00 41 0.642 P40692 L622H Disease 0.898 0.777 0.00 0 0.876 P40692 L636P Disease 0.928 0.923 0.03 23 0.903 P40692 L724M Disease 0.187 0.199 0.10 -42 0.182 P40692 L729V Polymorphism 0.229 0.189 0.25 -52 0.208 P40692 N338S Disease 0.488 0.431 0.84 12 0.343 P40692 N551T Disease 0.397 0.555 0.01 25 0.745 P40692 P309S Polymorphism 0.998 0.877 0.01 47 0.909 P40692 P603R Disease 0.252 0.263 0.37 5 0.275 P40692 P640S Disease 0.921 0.909 0.02 0 0.908 P40692 P648L Disease 0.954 0.884 0.01 31 0.890 P40692 P648S Disease 0.921 0.893 0.02 43 0.904 P40692 P654L Disease 0.939 0.924 0.00 24 0.908 P40692 Q542L Disease 0.766 0.893 0.00 32 0.853 P40692 Q542P Disease 0.819 0.964 0.01 30 0.871 P40692 Q689R Polymorphism 0.200 0.250 0.43 5 0.249 P40692 R182G Disease 0.796 0.865 0.08 50 0.907 P40692 R182K Disease 0.197 0.846 0.43 -3 0.330 P40692 R217C Disease 0.371 0.717 0.07 18 0.701 P40692 R217G Polymorphism 0.303 0.372 0.41 30 0.371 P40692 R226L Disease 0.420 0.746 0.17 14 0.580 P40692 R265H Polymorphism 0.970 0.858 0.00 71 0.939 P40692 R325Q Polymorphism 0.200 0.305 0.32 -5 0.182 P40692 R385C Disease 0.902 0.939 0.02 57 0.944 P40692 R385P Disease 0.419 0.942 0.23 37 0.663 P40692 R474Q Disease 0.187 0.091 0.64 -1 0.110 P40692 R659L Disease 0.466 0.844 0.04 51 0.873 P40692 R659P Disease 0.621 0.961 0.03 69 0.935 P40692 R659Q Polymorphism 0.397 0.780 0.08 56 0.826 P40692 R687W Disease 0.601 0.620 0.03 42 0.745 P40692 S193P Disease 0.620 0.850 0.12 10 0.825 P40692 S247P Disease 0.722 0.858 0.15 50 0.698 P40692 S295T Disease 0.435 0.118 0.45 19 0.313 P40692 S321I Disease 0.236 0.352 0.47 -15 0.306 P40692 S406N Polymorphism 0.231 0.220 0.49 -23 0.215 P40692 T117M Disease 0.891 0.741 0.00 54 0.915 P40692 T117R Disease 0.821 0.788 0.00 64 0.915 P40692 T662P Disease 0.240 0.638 0.26 -29 0.385 P40692 V185G Disease 0.848 0.530 0.00 38 0.807 P40692 V185L Disease 0.335 0.104 1.00 -24 0.083 P40692 V213M Polymorphism 0.344 0.415 0.15 -41 0.409 P40692 V326A Disease 0.569 0.325 0.00 16 0.625 P40692 V384D Polymorphism 0.582 0.936 0.12 56 0.844 P40692 V506A Disease 0.638 0.701 0.02 17 0.821 P40692 V716M Polymorphism 0.217 0.255 0.04 -11 0.261 P40692 Y379C Disease 0.725 0.780 0.09 29 0.841 P40692 Y646C Disease 0.943 0.781 0.00 60 0.935 P40763 Q32K Polymorphism NA 0.719 0.81 6 0.518 P40763 F384L Disease NA 0.763 1.00 -7 0.500 P40763 F384S Disease NA 0.932 0.08 34 0.688 P40763 F621V Disease 0.820 0.775 0.40 42 0.741 P40763 H437Y Disease 0.767 0.687 0.32 10 0.696 P40763 M143I Polymorphism NA 0.073 0.12 -25 0.066 P40763 R382L Disease NA 0.904 0.04 18 0.763 P40763 R382Q Disease NA 0.668 0.08 30 0.535 P40763 R382W Disease NA 0.847 0.01 45 0.810 P40763 R423Q Disease 0.372 0.657 0.06 30 0.549 P40763 S611N Disease 0.890 0.910 0.00 59 0.938 P40763 T389I Disease NA 0.555 0.21 -15 0.485 P40763 T622I Disease 0.407 0.500 0.02 24 0.727 P40763 V637L Disease 0.589 0.343 0.98 22 0.509 P40763 V637M Disease 0.822 0.490 0.03 59 0.820 P40763 Y657C Disease 0.972 0.582 0.00 58 0.931 P40818 A827G Polymorphism 0.763 0.874 0.25 46 0.855 P40879 R68Q Polymorphism 0.370 0.266 0.28 7 0.347 P40879 D468V Disease 0.894 0.894 0.00 51 0.920 P40879 G120S Disease 0.990 0.853 0.02 39 0.919 P40879 H124L Disease 0.849 0.750 0.04 62 0.919 P40879 N753S Polymorphism 0.115 0.323 0.51 12 0.145 P40879 P131R Disease 0.906 0.856 0.01 43 0.896 P40879 R554Q Polymorphism 0.111 0.563 0.70 -21 0.069 P40879 S206P Disease 0.637 0.770 0.07 15 0.556 P40926 A9V Polymorphism 0.026 0.174 0.36 13 0.105 P40939 E510Q Disease 0.994 0.821 0.00 58 0.943 P40939 I305N Disease NA 0.645 0.00 39 0.790 P40939 L342P Disease NA 0.707 0.00 55 0.846 P40939 Q358K Polymorphism NA 0.302 0.45 -29 0.179 P40939 V282D Disease NA 0.463 0.02 29 0.480 P40967 E370D Polymorphism 0.150 0.077 0.55 -12 0.099 P40967 P320H Polymorphism 0.513 0.340 0.03 23 0.592 P41091 K125R Polymorphism 0.111 0.615 0.38 -6 0.166 P41159 V94M Polymorphism 0.312 0.177 0.22 28 0.149 P41159 V110M Polymorphism 0.174 0.062 0.02 0 0.043 P41161 K348R Polymorphism 0.249 0.120 0.13 12 0.167 P41180 K47N Disease NA 0.137 0.51 -24 0.191 P41180 L11S Disease NA 0.791 0.00 -38 0.742 P41180 L13P Disease NA 0.714 0.05 7 0.496 P41180 P39A Disease NA 0.591 0.35 33 0.513 P41180 R62M Disease NA 0.248 0.04 24 0.398 P41180 R66C Disease NA 0.928 0.02 26 0.840 P41180 A116T Disease NA 0.397 0.44 -43 0.164 P41180 A843E Disease 0.471 0.931 0.13 43 0.860 P41180 A986S Polymorphism NA 0.151 0.00 20 0.025 P41180 A988G Disease NA 0.132 0.00 28 0.170 P41180 A988V Disease NA 0.096 0.00 -8 0.046 P41180 C131W Disease NA 0.882 0.19 63 0.910 P41180 C582F Disease 0.965 0.852 0.00 62 0.924 P41180 C582Y Disease 0.972 0.909 0.00 63 0.931 P41180 E191K Disease 0.274 0.313 0.75 -8 0.176 P41180 E297K Disease 0.660 0.516 0.02 53 0.842 P41180 E354A Disease 0.358 0.232 0.54 -10 0.180 P41180 E604K Disease 0.353 0.460 0.14 38 0.491 P41180 F128L Disease NA 0.306 0.66 18 0.203 P41180 F180C Disease 0.592 0.812 0.00 58 0.882 P41180 F612S Disease 0.550 0.272 0.39 18 0.521 P41180 F788C Disease 0.750 0.707 0.00 29 0.834 P41180 F788L Disease 0.244 0.543 0.00 3 0.469 P41180 F806S Disease 0.540 0.625 0.55 16 0.473 P41180 G143E Disease NA 0.952 0.00 75 0.923 P41180 G553R Disease 0.620 0.577 0.81 7 0.388 P41180 G557E Disease 0.271 0.909 0.01 32 0.549 P41180 G670E Disease 0.573 0.869 0.00 54 0.879 P41180 I686V Disease 0.381 0.031 0.51 -18 0.094 P41180 L125P Disease NA 0.856 0.02 20 0.600 P41180 L174R Disease 0.927 0.846 0.00 72 0.919 P41180 L616V Disease 0.634 0.648 0.10 -30 0.511 P41180 L727Q Disease 0.649 0.370 0.01 -18 0.636 P41180 N118K Disease NA 0.287 0.38 -25 0.181 P41180 Q681H Disease 0.551 0.437 0.00 35 0.544 P41180 R185Q Disease 0.678 0.580 0.00 55 0.681 P41180 R227L Disease 0.249 0.575 0.30 11 0.250 P41180 R227Q Disease 0.160 0.249 0.58 -7 0.211 P41180 R465Q Disease 0.379 0.471 0.35 -9 0.338 P41180 R795W Disease 0.986 0.923 0.00 61 0.930 P41180 R898Q Disease 0.299 0.198 0.28 20 0.318 P41180 R990G Polymorphism NA 0.176 0.00 39 0.295 P41180 S820F Disease 0.623 0.866 0.02 -9 0.816 P41180 T138M Disease NA 0.339 0.02 -30 0.387 P41180 T151M Disease NA 0.723 0.21 -30 0.403 P41180 Q1011E Polymorphism NA 0.118 0.00 7 0.152 P41181 A47V Disease 0.511 0.747 0.19 31 0.539 P41181 G64R Disease 0.997 0.936 0.00 77 0.936 P41181 L22V Disease 0.252 0.624 0.14 -28 0.418 P41181 L28P Disease 0.882 0.933 0.15 18 0.893 P41181 N68S Disease 0.998 0.951 0.00 65 0.933 P41181 Q57P Disease 0.948 0.962 0.06 35 0.890 P41181 V71M Disease 0.488 0.897 0.00 32 0.857 P41181 A147T Disease 0.259 0.348 0.03 36 0.351 P41181 A190T Disease 0.172 0.626 0.00 42 0.625 P41181 C181W Disease 0.872 0.720 0.00 61 0.924 P41181 E258K Disease NA 0.247 0.34 29 0.302 P41181 G100V Disease 0.943 0.872 0.00 26 0.868 P41181 G175R Disease 0.887 0.872 0.02 62 0.925 P41181 P185A Disease 0.919 0.811 0.00 54 0.918 P41181 P262L Disease NA 0.222 0.00 -6 0.244 P41181 R187C Disease 0.975 0.937 0.00 65 0.931 P41181 S216P Disease NA 0.898 0.01 21 0.849 P41181 T125M Disease 0.322 0.465 0.22 6 0.240 P41181 T126M Disease 0.506 0.695 0.02 4 0.622 P41181 V168M Disease 0.542 0.774 0.00 24 0.815 P41181 V194I Polymorphism 0.087 0.078 0.56 -29 0.096 P41181 W202C Disease 0.979 0.951 0.00 70 0.929 P41182 A493T Polymorphism 0.214 0.536 0.10 -20 0.204 P41217 P46T Polymorphism 0.082 0.027 1.00 -11 0.056 P41217 V76G Polymorphism 0.385 0.442 0.01 23 0.138 P41225 A43T Polymorphism NA 0.097 0.13 -24 0.030 P41226 P712S Polymorphism NA 0.927 0.00 44 0.877 P41229 D87G Disease 0.834 0.500 0.01 43 0.796 P41229 A388P Disease 0.875 0.772 0.01 34 0.857 P41229 D402Y Disease 0.946 0.801 0.00 5 0.870 P41229 E698K Disease 0.547 0.720 0.01 -6 0.552 P41229 F642L Disease 0.722 0.664 0.17 33 0.769 P41229 L731F Disease 0.746 0.712 0.03 28 0.789 P41229 R750W Disease 0.972 0.968 0.00 40 0.944 P41229 S451R Disease 0.888 0.860 0.00 66 0.912 P41229 Y751C Disease 0.880 0.929 0.00 17 0.902 P41231 R312S Polymorphism 0.409 0.480 0.71 -3 0.311 P41235 E285Q Disease 0.991 0.850 0.01 63 0.943 P41235 P445S Polymorphism NA 0.057 0.57 0 0.061 P41235 R136W Disease 0.863 0.875 0.01 43 0.882 P41235 V402I Disease NA 0.133 0.26 -27 0.121 P41240 P45L Polymorphism 0.558 0.219 0.03 10 0.558 P41240 G287D Polymorphism 0.173 0.520 0.65 21 0.173 P41240 H442R Polymorphism 0.177 0.477 0.24 -17 0.176 P41240 R398Q Polymorphism 0.174 0.171 0.75 -26 0.114 P41247 R187Q Polymorphism 0.268 0.102 0.47 1 0.166 P41250 E125G Disease NA 0.766 0.04 40 0.717 P41250 G294R Disease NA 0.832 0.10 54 0.900 P41250 G580R Disease 0.917 0.960 0.00 80 0.951 P41250 L183P Disease NA 0.854 0.00 43 0.859 P41252 M769I Polymorphism 0.323 0.243 0.50 16 0.325 P41273 P17A Polymorphism NA 0.085 NA 17 0.068 P41440 A558V Polymorphism NA 0.098 NA 8 0.066 P41587 A39T Polymorphism 0.199 0.146 0.54 -19 0.206 P41597 L45V Polymorphism 0.366 0.350 0.27 -15 0.299 P41597 V64I Polymorphism 0.066 0.199 0.64 -42 0.178 P41732 E53K Polymorphism NA 0.571 0.30 52 0.590 P41732 A127T Polymorphism 0.579 0.368 0.58 -12 0.555 P41732 P172H Disease 0.820 0.289 0.54 11 0.555 P41968 T6K Polymorphism NA 0.258 NA 47 0.076 P42081 D323N Polymorphism NA 0.136 NA 24 0.026 P42127 Q61P Polymorphism 0.236 0.165 0.04 1 0.181 P42166 K478N Polymorphism 0.248 0.393 NA 35 0.143 P42166 L238R Polymorphism 0.475 0.402 NA 19 0.159 P42166 Q599E Polymorphism 0.202 0.210 NA 24 0.114 P42166 S293A Polymorphism 0.241 0.082 NA 0 0.057 P42167 A287P Polymorphism 0.487 0.227 0.00 -40 0.199 P42224 L600P Disease 0.973 0.977 0.00 44 0.943 P42224 L706S Disease 0.436 0.737 0.01 18 0.586 P42226 M181R Polymorphism NA 0.327 0.43 9 0.229 P42261 A536S Polymorphism 0.164 0.505 1.00 -41 0.201 P42261 D487N Polymorphism 0.493 0.883 0.02 70 0.928 P42261 F588L Polymorphism 0.297 0.500 0.73 -11 0.253 P42261 P521T Polymorphism 0.885 0.354 0.00 47 0.674 P42263 F525L Polymorphism 0.375 0.886 0.00 29 0.747 P42263 G833R Disease NA 0.794 0.00 -17 0.746 P42263 M706T Disease 0.974 0.850 0.00 28 0.934 P42263 R450Q Disease 0.420 0.565 0.03 -8 0.506 P42263 R631S Disease 0.992 0.912 0.00 9 0.930 P42285 A346P Polymorphism 0.605 0.597 0.25 45 0.621 P42330 M175I Polymorphism 0.430 0.288 0.14 -14 0.383 P42330 P180S Polymorphism 0.287 0.492 0.02 0 0.458 P42330 R170C Polymorphism 0.403 0.376 0.18 6 0.310 P42336 I43V Polymorphism 0.193 0.088 0.27 -29 0.117 P42336 E542K Disease 0.412 0.257 0.31 -6 0.305 P42336 E545G Disease 0.686 0.247 0.11 30 0.593 P42336 E545K Disease 0.341 0.257 0.39 11 0.337 P42336 I391M Polymorphism 0.627 0.379 0.02 28 0.566 P42336 S332R Polymorphism 0.229 0.210 1.00 24 0.143 P42336 H1047R Disease 0.296 0.209 0.32 6 0.187 P42338 Q672H Polymorphism 0.600 0.104 1.00 -1 0.079 P42356 M322V Polymorphism NA 0.239 NA -30 0.342 P42356 V1793L Polymorphism 0.658 0.775 0.09 6 0.786 P42357 P259L Disease NA 0.917 0.00 22 0.700 P42357 R206T Disease NA 0.722 0.43 -23 0.381 P42357 R208L Disease NA 0.927 0.05 49 0.620 P42357 R322P Disease NA 0.885 0.12 40 0.856 P42566 I822M Polymorphism 0.099 0.057 0.13 -17 0.032 P42574 E190D Polymorphism 0.168 0.622 0.33 -8 0.289 P42575 A105G Polymorphism 0.449 0.259 0.43 -6 0.370 P42658 L854P Polymorphism NA 0.292 0.09 0 0.226 P42679 A496T Polymorphism 0.104 0.095 0.53 -27 0.107 P42680 R44Q Polymorphism NA 0.373 0.01 21 0.462 P42681 R45H Polymorphism 0.048 0.069 0.03 19 0.079 P42681 R63C Polymorphism 0.143 0.196 0.05 46 0.287 P42681 R336Q Polymorphism 0.117 0.203 0.64 -22 0.148 P42684 K930R Polymorphism NA 0.228 0.02 15 0.286 P42684 P996R Polymorphism NA 0.119 0.02 27 0.175 P42684 V946M Polymorphism NA 0.169 0.11 25 0.141 P42684 T1101A Polymorphism NA 0.050 0.00 -21 0.050 P42685 G122R Polymorphism 0.141 0.837 0.04 33 0.358 P42685 I100V Polymorphism 0.177 0.475 0.50 7 0.272 P42685 S133L Polymorphism 0.339 0.380 0.12 13 0.432 P42694 V74M Polymorphism 0.216 0.119 NA 11 0.104 P42695 P907T Polymorphism 0.293 0.064 NA 14 0.099 P42695 R622Q Polymorphism 0.321 0.075 NA -4 0.029 P42701 P3Q Polymorphism NA 0.456 NA -26 0.270 P42701 G378R Polymorphism NA 0.022 0.24 24 0.031 P42701 H339Q Polymorphism NA 0.073 0.32 30 0.100 P42701 M365T Polymorphism NA 0.068 0.26 18 0.021 P42701 Q214R Polymorphism NA 0.024 0.83 -10 0.022 P42701 R156H Polymorphism NA 0.125 0.09 2 0.110 P42701 R213W Disease NA 0.314 0.01 57 0.570 P42702 I633M Polymorphism 0.270 0.178 0.08 33 0.291 P42702 S279P Disease NA 0.376 0.28 16 0.466 P42702 S664L Polymorphism 0.557 0.109 0.44 23 0.154 P42704 A354V Disease NA 0.179 0.10 37 0.173 P42765 M217V Polymorphism 0.221 0.130 1.00 -16 0.078 P42768 C43W Disease 0.872 0.959 0.00 56 0.938 P42768 C73R Disease 0.869 0.922 0.01 41 0.888 P42768 E31K Disease 0.603 0.908 0.00 15 0.818 P42768 F84L Disease 0.691 0.820 0.03 20 0.840 P42768 G70W Disease 0.986 0.975 0.00 59 0.972 P42768 G89D Disease 0.241 0.211 1.00 28 0.206 P42768 P58L Disease 0.414 0.521 0.00 31 0.720 P42768 Q52H Disease 0.750 0.802 0.02 63 0.910 P42768 R86C Disease 0.938 0.834 0.00 53 0.935 P42768 R86H Disease 0.779 0.712 0.01 53 0.887 P42768 R86L Disease 0.767 0.880 0.02 44 0.863 P42768 S82P Disease 0.425 0.968 0.03 26 0.798 P42768 T45M Disease 0.494 0.457 0.00 32 0.583 P42768 W97C Disease 0.893 0.907 0.00 51 0.925 P42768 A134T Disease 0.395 0.739 0.00 6 0.549 P42768 E131K Disease 0.540 0.875 0.07 27 0.719 P42768 E133K Disease 0.688 0.932 0.02 37 0.852 P42768 G187C Disease 0.555 0.205 NA 24 0.380 P42768 K476E Disease 0.333 0.318 NA 17 0.189 P42768 L270P Disease 0.829 0.911 0.00 20 0.880 P42771 A60T Polymorphism 0.669 0.735 0.15 -18 0.823 P42771 A68L Disease 0.877 0.825 0.01 19 0.884 P42771 A68V Polymorphism 0.834 0.657 0.02 19 0.823 P42771 A85T Polymorphism 0.923 0.789 0.00 52 0.919 P42771 D74Y Disease 0.944 0.925 0.00 53 0.955 P42771 D84Y Disease 0.927 0.909 0.57 -39 0.868 P42771 G35A Disease 0.131 0.411 0.04 -13 0.244 P42771 G35E Disease 0.092 0.500 0.22 51 0.200 P42771 G35V Disease 0.250 0.513 0.01 42 0.638 P42771 G67R Disease 0.930 0.858 0.00 54 0.950 P42771 G89D Disease 0.877 0.957 0.06 67 0.956 P42771 G89S Disease 0.803 0.929 0.04 61 0.952 P42771 H83Q Polymorphism 0.893 0.818 0.07 48 0.908 P42771 H98P Disease 0.437 0.909 0.04 40 0.787 P42771 H98Q Disease 0.186 0.319 0.04 16 0.325 P42771 I49T Polymorphism 0.505 0.635 0.01 38 0.724 P42771 L32P Disease 0.824 0.948 0.00 60 0.953 P42771 L62P Disease 0.583 0.924 0.04 41 0.842 P42771 L94Q Disease 0.850 0.814 0.02 18 0.861 P42771 L97R Disease 0.932 0.989 0.00 69 0.959 P42771 M53I Disease 0.493 0.645 0.10 15 0.656 P42771 N71K Disease 0.600 0.869 0.01 22 0.750 P42771 N71S Polymorphism 0.575 0.693 0.02 9 0.672 P42771 P48L Disease 0.422 0.389 0.02 42 0.581 P42771 P81T Disease 0.537 0.775 0.04 53 0.847 P42771 Q50R Disease 0.593 0.832 0.25 15 0.814 P42771 R24C Disease 0.635 0.224 0.03 39 0.510 P42771 R24P Disease 0.350 0.776 0.16 26 0.645 P42771 R58Q Polymorphism 0.116 0.085 0.65 -23 0.082 P42771 R80P Disease 0.542 0.798 0.22 55 0.868 P42771 R87P Disease 0.882 0.986 0.27 43 0.896 P42771 R87W Disease 0.958 0.953 0.02 -6 0.908 P42771 R99P Disease 0.360 0.888 0.06 26 0.693 P42771 R99W Polymorphism 0.727 0.542 0.01 15 0.711 P42771 S56I Polymorphism 0.672 0.575 0.01 15 0.721 P42771 T77P Disease 0.641 0.637 0.05 2 0.679 P42771 V59G Disease 0.848 0.770 0.00 34 0.863 P42771 A100L Disease 0.176 0.398 0.66 -6 0.313 P42771 A100P Polymorphism 0.425 0.803 0.27 27 0.748 P42771 A102E Disease 0.834 0.939 0.00 62 0.954 P42771 A102T Polymorphism 0.682 0.880 0.01 49 0.877 P42771 A118T Disease 0.726 0.869 0.00 29 0.855 P42771 A148T Polymorphism NA 0.180 0.49 -16 0.133 P42771 G101W Disease 0.936 0.882 0.00 56 0.954 P42771 G122R Disease 0.849 0.885 0.01 39 0.800 P42771 L117M Disease 0.551 0.566 0.08 20 0.506 P42771 R107C Disease 0.356 0.356 0.07 20 0.407 P42771 R107H Polymorphism 0.377 0.310 0.15 6 0.280 P42771 R124C Polymorphism 0.570 0.156 0.07 0 0.334 P42771 V126D Disease 0.894 0.922 0.00 54 0.952 P42773 T126M Polymorphism 0.551 0.447 0.02 41 0.656 P42785 T444S Polymorphism 0.102 0.184 1.00 -19 0.146 P42892 T341I Polymorphism 0.342 0.372 0.18 -30 0.495 P42892 W630R Polymorphism 0.989 0.932 0.00 77 0.949 P42898 R51P Disease NA 0.435 0.23 26 0.523 P42898 R52Q Disease NA 0.189 0.62 -23 0.293 P42898 E429A Polymorphism 0.179 0.119 0.03 5 0.166 P42898 E470A Polymorphism 0.165 0.126 0.14 -1 0.217 P42898 E586K Disease 0.596 0.697 0.00 61 0.862 P42898 G387D Disease 0.794 0.709 0.00 61 0.914 P42898 G422R Polymorphism 0.176 0.312 0.04 50 0.494 P42898 G566E Polymorphism 0.360 0.549 0.01 57 0.737 P42898 L323P Disease 0.865 0.939 0.00 43 0.878 P42898 N324S Disease 0.535 0.891 0.00 53 0.827 P42898 P251L Disease 0.495 0.801 0.00 48 0.766 P42898 P572L Disease 0.545 0.451 0.01 46 0.649 P42898 R157Q Disease 0.559 0.913 0.00 56 0.904 P42898 R325C Disease 0.444 0.865 0.04 38 0.855 P42898 R335C Disease 0.647 0.717 0.07 34 0.760 P42898 R357C Disease NA 0.591 0.00 63 0.809 P42898 R377C Disease 0.904 0.832 0.00 71 0.933 P42898 T227M Disease 0.862 0.753 0.00 63 0.918 P42898 T653M Polymorphism NA 0.130 0.00 1 0.177 P42898 W339G Disease 0.210 0.291 0.02 35 0.329 P43003 P290R Disease 0.994 0.929 0.00 58 0.956 P43005 A27G Polymorphism NA 0.316 0.51 -62 0.300 P43005 F50Y Polymorphism 0.116 0.397 0.53 -52 0.134 P43007 G37R Polymorphism NA 0.285 0.66 -23 0.241 P43026 C400Y Disease 0.998 0.936 0.00 72 0.955 P43026 E491K Disease 0.837 0.895 0.12 7 0.773 P43026 H440L Disease 0.915 0.863 0.15 51 0.889 P43026 L373R Disease NA 0.389 0.52 -51 0.263 P43026 L441P Disease 0.946 0.882 0.00 33 0.876 P43026 M173V Disease 0.686 0.514 0.01 23 0.741 P43026 P436T Disease 0.995 0.728 0.03 51 0.934 P43026 R378Q Disease 0.460 0.574 0.19 -5 0.469 P43026 R380Q Disease 0.859 0.578 0.03 2 0.786 P43026 R438L Disease 0.905 0.744 0.40 11 0.755 P43026 S276A Polymorphism 0.085 0.153 0.51 -71 0.120 P43026 S439T Disease 0.767 0.637 0.29 5 0.600 P43026 S475N Disease 0.854 0.845 0.16 30 0.674 P43034 F31S Disease 0.677 0.854 0.01 49 0.855 P43034 D317H Disease 0.840 0.679 0.00 70 0.970 P43034 G162S Disease 0.224 0.561 0.27 20 0.315 P43034 H149R Disease 0.719 0.667 0.00 67 0.848 P43034 H277P Disease 0.658 0.355 0.01 52 0.659 P43034 R241P Disease 0.522 0.258 0.26 38 0.440 P43034 S169P Disease 0.736 0.554 0.00 58 0.933 P43080 P50L Disease 0.228 0.616 0.11 -1 0.474 P43080 Y99C Disease 0.869 0.940 0.00 62 0.944 P43080 E155G Disease 0.736 0.957 0.00 61 0.933 P43115 M169L Polymorphism 0.083 0.517 0.23 21 0.124 P43115 T319M Polymorphism 0.139 0.096 0.27 13 0.177 P43119 V25M Polymorphism 0.411 0.187 0.03 -5 0.326 P43121 E89G Polymorphism 0.409 0.138 0.40 32 0.259 P43146 I759M Polymorphism 0.388 0.465 0.27 26 0.476 P43146 L679R Polymorphism 0.182 0.446 0.69 61 0.222 P43146 R201G Polymorphism 0.352 0.385 0.41 46 0.313 P43146 H1191L Polymorphism 0.269 0.088 0.02 19 0.163 P43146 M1017V Polymorphism 0.161 0.449 0.28 7 0.065 P43155 A624P Polymorphism 0.391 0.437 0.07 -18 0.407 P43155 L372M Polymorphism 0.108 0.146 0.34 -44 0.140 P43220 R20K Polymorphism NA 0.164 1.00 -35 0.153 P43220 A316T Polymorphism 0.309 0.214 0.67 -9 0.202 P43220 R421Q Polymorphism 0.379 0.440 0.42 1 0.325 P43235 G79E Disease 0.610 0.905 0.00 52 0.896 P43235 A277V Disease 0.357 0.776 0.01 32 0.607 P43235 G146R Disease 0.900 0.924 0.00 64 0.829 P43235 L309P Disease 0.708 0.904 0.08 16 0.879 P43246 A2T Disease NA 0.206 0.02 -47 0.185 P43246 T8M Polymorphism NA 0.193 0.01 28 0.339 P43246 A45V Disease NA 0.212 0.10 -5 0.250 P43246 H46Q Disease NA 0.392 0.00 42 0.618 P43246 L93F Disease NA 0.817 0.00 44 0.686 P43246 R96H Polymorphism NA 0.510 0.23 2 0.530 P43246 T33P Disease NA 0.847 0.07 46 0.849 P43246 T44M Disease NA 0.433 0.00 48 0.625 P43246 Y43C Polymorphism NA 0.943 0.00 62 0.934 P43246 Y98C Disease NA 0.765 0.06 24 0.608 P43246 A272V Polymorphism NA 0.595 0.11 30 0.538 P43246 A305T Disease NA 0.643 0.21 -2 0.467 P43246 A600V Disease NA 0.867 0.00 49 0.888 P43246 A636P Disease NA 0.852 0.07 4 0.837 P43246 A714V Disease NA 0.835 0.00 46 0.867 P43246 A834T Disease NA 0.911 0.00 40 0.871 P43246 C333Y Disease NA 0.886 0.00 64 0.923 P43246 C641G Polymorphism NA 0.629 0.00 50 0.774 P43246 C697F Disease NA 0.911 0.00 46 0.888 P43246 C697R Disease NA 0.875 0.00 58 0.912 P43246 D167H Disease NA 0.823 0.00 75 0.919 P43246 D283Y Disease NA 0.534 0.06 42 0.610 P43246 D603N Disease NA 0.905 0.00 62 0.920 P43246 D660G Disease NA 0.315 0.41 -3 0.307 P43246 E198G Disease NA 0.872 0.00 52 0.898 P43246 E562V Disease 0.496 0.350 0.07 21 0.429 P43246 E647K Disease NA 0.248 0.86 3 0.264 P43246 E749K Disease NA 0.930 0.00 75 0.942 P43246 E853A Disease NA 0.310 0.81 0 0.292 P43246 E886G Disease NA 0.646 0.04 14 0.553 P43246 G162A Disease NA 0.751 0.47 39 0.572 P43246 G162R Disease NA 0.894 0.00 71 0.922 P43246 G164R Disease NA 0.567 0.00 48 0.770 P43246 G322D Polymorphism NA 0.658 0.53 33 0.462 P43246 G674S Disease NA 0.917 0.00 53 0.902 P43246 G692R Disease NA 0.907 0.00 74 0.924 P43246 H639R Disease NA 0.910 0.00 74 0.928 P43246 H639Y Disease NA 0.939 0.00 69 0.946 P43246 H839R Disease NA 0.255 0.27 -26 0.152 P43246 I145M Disease NA 0.230 0.10 27 0.346 P43246 I169V Disease NA 0.082 0.03 -1 0.105 P43246 I216V Disease NA 0.138 0.89 -7 0.109 P43246 I679T Disease NA 0.500 0.00 21 0.752 P43246 I770V Polymorphism NA 0.177 0.16 -3 0.242 P43246 K110T Disease NA 0.771 0.27 26 0.636 P43246 K246Q Disease NA 0.326 0.51 10 0.404 P43246 K393M Disease 0.630 0.677 0.00 52 0.876 P43246 K845E Disease NA 0.528 0.34 -18 0.432 P43246 K931T Disease NA 0.236 0.06 4 0.173 P43246 L173P Disease NA 0.636 0.01 36 0.775 P43246 L175P Disease NA 0.673 0.00 36 0.777 P43246 L187P Disease NA 0.908 0.00 59 0.918 P43246 L390F Disease 0.361 0.650 0.01 36 0.704 P43246 L911R Polymorphism NA 0.771 0.01 32 0.658 P43246 M492V Disease 0.195 0.357 0.22 20 0.289 P43246 M688I Disease NA 0.678 0.03 41 0.660 P43246 M729V Disease NA 0.885 0.00 42 0.866 P43246 M779I Polymorphism NA 0.391 0.19 34 0.197 P43246 M813V Disease NA 0.522 0.00 45 0.776 P43246 N127S Disease NA 0.681 0.00 46 0.786 P43246 N139S Disease NA 0.393 0.14 9 0.333 P43246 N583S Disease 0.296 0.257 0.51 -47 0.193 P43246 N596S Disease 0.296 0.295 0.03 -18 0.189 P43246 N671Y Disease NA 0.925 0.00 72 0.937 P43246 N835H Polymorphism NA 0.587 0.01 -34 0.469 P43246 P336S Disease NA 0.191 0.27 -13 0.262 P43246 P349L Disease NA 0.887 0.00 49 0.890 P43246 P622L Disease NA 0.946 0.00 58 0.936 P43246 P670L Polymorphism NA 0.910 0.00 51 0.900 P43246 Q629R Disease NA 0.490 0.40 -1 0.284 P43246 R106K Polymorphism NA 0.211 0.10 -45 0.197 P43246 R359S Disease 0.399 0.904 0.00 59 0.908 P43246 R524P Disease 0.581 0.915 0.00 47 0.775 P43246 S323C Disease NA 0.506 0.04 20 0.731 P43246 S323Y Disease NA 0.420 0.03 19 0.436 P43246 S554R Disease 0.431 0.615 0.09 -6 0.502 P43246 S723F Disease NA 0.942 0.00 66 0.945 P43246 T335I Disease NA 0.832 0.00 53 0.894 P43246 T552P Disease 0.484 0.901 0.00 44 0.861 P43246 T564A Disease 0.212 0.089 0.19 -35 0.148 P43246 T732I Disease NA 0.709 0.02 10 0.575 P43246 T807S Polymorphism NA 0.061 0.62 -26 0.109 P43246 T905R Disease NA 0.201 0.00 23 0.334 P43246 V102I Disease NA 0.100 1.00 -20 0.075 P43246 V161D Disease NA 0.469 0.10 65 0.696 P43246 V163D Disease NA 0.523 0.00 59 0.729 P43246 V163G Disease NA 0.475 0.00 36 0.614 P43246 V923E Disease NA 0.474 0.14 27 0.553 P43246 Y656H Disease NA 0.279 0.58 -8 0.256 P43250 T73M Polymorphism NA 0.670 0.00 46 0.779 P43251 A171T Disease 0.400 0.638 0.07 31 0.736 P43251 D228Y Disease 0.627 0.720 0.00 53 0.878 P43251 D444H Disease 0.691 0.703 0.02 48 0.864 P43251 F128V Disease 0.439 0.469 0.01 9 0.389 P43251 G451D Disease 0.655 0.883 0.43 59 0.705 P43251 H323R Disease 0.510 0.500 0.07 41 0.634 P43251 P391S Polymorphism 0.241 0.142 0.53 -25 0.105 P43251 Q456H Disease 0.820 0.726 0.01 56 0.908 P43251 R538C Disease 0.925 0.881 0.01 69 0.936 P43251 T532M Disease 0.686 0.751 0.00 48 0.691 P43268 R437C Polymorphism 0.842 0.642 0.01 51 0.821 P43304 K453Q Polymorphism 0.415 0.500 0.52 -45 0.426 P43304 R264H Polymorphism 0.480 0.732 0.11 15 0.561 P43304 R525H Polymorphism 0.601 0.679 0.12 16 0.592 P43320 A65S Polymorphism 0.186 0.193 0.28 -21 0.142 P43351 R70W Polymorphism 0.936 0.584 0.01 40 0.822 P43355 A63T Polymorphism NA 0.243 0.44 -21 0.262 P43355 R72Q Polymorphism NA 0.355 0.23 -12 0.206 P43355 T32A Polymorphism NA 0.176 1.00 0 0.126 P43360 S152I Polymorphism 0.325 0.573 0.19 -13 0.423 P43361 R121H Polymorphism 0.174 0.178 1.00 -33 0.099 P43364 S191R Polymorphism NA 0.820 0.19 -3 0.550 P43403 P191L Polymorphism NA 0.215 0.07 2 0.330 P43403 R175L Polymorphism 0.401 0.540 0.71 5 0.509 P43403 R465H Disease 0.428 0.848 0.00 56 0.891 P43403 S518R Disease 0.658 0.668 0.64 36 0.808 P43403 W523L Polymorphism 0.702 0.835 0.00 61 0.916 P43487 A145V Polymorphism 0.385 0.094 0.37 -14 0.214 P43489 R10C Polymorphism NA 0.303 0.01 -49 0.246 P43626 P37R Polymorphism 0.696 0.130 0.15 25 0.445 P43626 D184N Polymorphism 0.225 0.110 0.12 1 0.239 P43626 K237E Polymorphism 0.305 0.703 0.81 13 0.416 P43626 P135L Polymorphism 0.606 0.179 0.07 39 0.416 P43626 P175T Polymorphism 0.501 0.154 0.58 8 0.228 P43626 R266C Polymorphism 0.678 0.935 0.19 23 0.769 P43627 A9V Polymorphism 0.583 0.409 0.97 -41 0.551 P43628 V9A Polymorphism 0.583 0.081 0.56 -59 0.077 P43628 H34Q Polymorphism 0.304 0.137 0.51 -9 0.130 P43628 P37R Polymorphism 0.696 0.130 0.15 25 0.445 P43628 A304T Polymorphism 0.339 0.761 0.24 -28 0.515 P43628 P229L Polymorphism 0.425 0.570 0.67 6 0.402 P43628 R242I Polymorphism 0.569 0.812 0.02 39 0.776 P43628 R318H Polymorphism 0.258 0.328 0.09 -8 0.353 P43629 I68V Polymorphism 0.067 0.104 0.61 -26 0.072 P43629 I75L Polymorphism 0.053 0.269 0.43 -6 0.138 P43629 G259R Polymorphism 0.519 0.500 0.06 37 0.520 P43629 L362R Polymorphism 0.133 0.244 0.40 6 0.162 P43629 P220L Polymorphism 0.262 0.117 1.00 -1 0.114 P43630 P40A Polymorphism NA 0.173 0.75 -33 0.142 P43630 A228P Polymorphism 0.658 0.239 0.04 31 0.608 P43630 K439Q Polymorphism 0.194 0.428 0.09 -9 0.453 P43630 P132T Polymorphism 0.214 0.178 0.06 17 0.263 P43630 T397M Polymorphism 0.417 0.729 0.01 36 0.615 P43631 A9V Polymorphism 0.583 0.518 0.77 -65 0.480 P43632 N68D Polymorphism 0.268 0.142 0.60 -19 0.132 P43632 P89R Polymorphism 0.630 0.144 0.13 24 0.415 P43632 P92H Polymorphism 0.858 0.126 0.14 -9 0.577 P43632 V93D Polymorphism 0.342 0.125 0.87 -22 0.119 P43632 A205S Polymorphism 0.488 0.103 1.00 -31 0.105 P43632 K254N Polymorphism 0.526 0.609 0.38 -48 0.542 P43632 N178H Polymorphism 0.697 0.130 0.41 17 0.238 P43632 S103C Polymorphism 0.816 0.180 0.04 15 0.549 P43657 D63V Disease 0.998 0.816 0.00 56 0.938 P43657 I33V Polymorphism 0.246 0.053 0.95 -29 0.032 P43657 E189K Disease 0.579 0.572 0.30 34 0.768 P43657 I188F Disease 0.626 0.670 0.03 -20 0.478 P43681 E387G Polymorphism NA 0.292 0.53 21 0.293 P43681 S280F Disease 0.984 0.717 0.00 30 0.863 P43681 S280L Disease 0.975 0.645 0.00 27 0.842 P43681 S517L Polymorphism NA 0.081 0.35 -8 0.082 P43694 S52F Disease NA 0.189 0.00 25 0.356 P43694 G296S Disease 0.952 0.888 0.00 57 0.941 P43694 S377G Polymorphism 0.144 0.067 0.48 9 0.078 P43699 R213S Disease 0.999 0.904 0.00 70 0.948 P43699 V205F Disease 0.964 0.861 0.00 57 0.951 P43699 W208L Disease 0.999 0.861 0.00 70 0.953 P45378 R74H Disease NA 0.778 0.04 39 0.825 P45379 F80L Disease 0.286 0.560 1.00 -6 0.441 P45379 I89N Disease 0.882 0.968 0.00 -14 0.891 P45379 A114V Disease 0.338 0.179 0.14 -11 0.267 P45379 E173K Disease 0.540 0.316 0.03 19 0.548 P45379 E254D Disease 0.406 0.742 0.07 7 0.594 P45379 F120I Disease 0.869 0.748 0.37 20 0.858 P45379 F120V Disease 0.873 0.808 0.32 21 0.880 P45379 N281I Disease NA 0.180 0.34 -5 0.239 P45379 R102L Disease NA 0.797 0.05 19 0.773 P45379 R102Q Disease NA 0.469 0.12 -8 0.447 P45379 R102W Disease NA 0.642 0.01 14 0.670 P45379 R104L Disease NA 0.952 0.02 34 0.842 P45379 R139K Polymorphism 0.121 0.083 1.00 -49 0.094 P45379 R140C Disease 0.968 0.901 0.00 34 0.948 P45379 R140K Polymorphism 0.723 0.842 0.04 -9 0.819 P45379 R141W Disease 0.976 0.850 0.00 22 0.940 P45379 R151W Disease 0.976 0.741 0.02 40 0.912 P45379 R215L Disease 0.909 0.856 0.05 -10 0.899 P45379 R288C Disease 0.656 0.310 0.06 26 0.539 P45379 R288P Disease 0.490 0.620 0.17 35 0.582 P45379 R296C Disease 0.958 0.767 0.00 59 0.964 P45379 S189F Disease 0.833 0.892 0.01 14 0.852 P45379 S249T Polymorphism 0.172 0.114 0.98 -65 0.104 P45381 A57T Disease 0.648 0.938 0.00 57 0.921 P45381 D68A Disease 0.765 0.877 0.00 59 0.919 P45381 E24G Disease 0.737 0.934 0.00 73 0.944 P45381 G27R Disease 0.892 0.967 0.01 68 0.946 P45381 H21P Disease 0.877 0.989 0.00 74 0.940 P45381 I16T Disease 0.538 0.621 0.01 33 0.604 P45381 A287T Disease 0.573 0.893 0.00 46 0.862 P45381 A305E Disease 0.510 0.224 0.08 42 0.475 P45381 C152R Disease 0.747 0.560 0.16 53 0.767 P45381 C152W Disease 0.900 0.529 0.02 53 0.870 P45381 C152Y Disease 0.754 0.510 0.07 39 0.700 P45381 D114E Disease 0.427 0.869 0.00 67 0.917 P45381 D114Y Disease 0.829 0.967 0.00 69 0.949 P45381 D249V Disease 0.652 0.734 0.04 44 0.838 P45381 E285A Disease 0.661 0.830 0.00 59 0.908 P45381 F295S Disease 0.785 0.810 0.01 51 0.896 P45381 G123E Disease 0.867 0.924 0.00 55 0.943 P45381 G274R Disease 0.547 0.957 0.06 54 0.786 P45381 H244R Disease 0.779 0.885 0.00 70 0.926 P45381 I143T Disease 0.581 0.376 0.09 21 0.570 P45381 M195R Disease 0.809 0.684 0.06 51 0.883 P45381 P181T Disease 0.696 0.751 0.01 37 0.832 P45381 P183H Disease 0.483 0.682 0.00 50 0.814 P45381 P280L Disease 0.839 0.943 0.00 35 0.826 P45381 P280S Disease 0.748 0.888 0.00 37 0.761 P45381 R168C Disease 0.784 0.473 0.04 37 0.572 P45381 R168H Disease 0.451 0.398 0.17 39 0.437 P45381 V186F Disease 0.715 0.601 0.16 23 0.660 P45381 Y231C Disease 0.892 0.714 0.01 49 0.908 P45452 H2L Polymorphism NA 0.175 0.07 -41 0.094 P45452 F75S Disease 0.728 0.660 0.00 1 0.798 P45954 R13K Polymorphism NA 0.105 1.00 -13 0.036 P45954 E376G Polymorphism 0.806 0.705 0.11 41 0.856 P45954 L255F Disease 0.729 0.331 0.32 32 0.606 P45954 S209G Polymorphism 0.762 0.666 0.13 53 0.847 P45983 E365K Polymorphism NA 0.276 0.55 -10 0.271 P45984 A246T Polymorphism NA 0.227 0.34 -37 0.363 P45984 G268A Polymorphism NA 0.297 0.13 -29 0.229 P45984 R366I Polymorphism NA 0.314 0.24 15 0.316 P46013 A872V Polymorphism NA 0.024 NA -19 0.015 P46013 I631L Polymorphism NA 0.078 0.10 -5 0.109 P46013 L854V Polymorphism NA 0.041 NA 7 0.016 P46013 Q574P Polymorphism NA 0.215 0.04 -4 0.113 P46013 D2760G Polymorphism NA 0.079 0.05 14 0.123 P46013 E1403V Polymorphism NA 0.083 0.03 41 0.138 P46013 L1470W Polymorphism NA 0.165 0.01 31 0.290 P46013 L1951I Polymorphism NA 0.103 0.20 25 0.147 P46013 P1622L Polymorphism NA 0.064 0.00 -18 0.118 P46013 P2608L Polymorphism NA 0.068 0.00 18 0.106 P46013 Q2904R Polymorphism NA 0.041 0.03 1 0.071 P46013 R2649H Polymorphism NA 0.070 0.03 31 0.083 P46013 S2793N Polymorphism NA 0.097 0.25 27 0.049 P46013 T1120S Polymorphism NA 0.076 NA 4 0.110 P46013 T1247I Polymorphism NA 0.102 NA 24 0.105 P46013 T1849A Polymorphism NA 0.050 0.07 10 0.133 P46013 T2720P Polymorphism NA 0.221 0.09 16 0.332 P46013 T2868S Polymorphism NA 0.121 0.00 -8 0.124 P46013 T3150S Polymorphism NA 0.033 NA -42 0.005 P46019 E38Q Polymorphism 0.118 0.172 0.33 -12 0.116 P46019 D299G Disease 0.903 0.966 0.00 59 0.953 P46019 G193V Disease 0.898 0.951 0.00 36 0.891 P46019 H132P Disease 0.958 0.980 0.00 55 0.968 P46019 H132Y Disease 0.919 0.947 0.00 58 0.954 P46019 K189E Disease 0.714 0.922 0.00 38 0.868 P46019 P399S Disease 0.828 0.824 0.00 48 0.851 P46019 R186C Disease 0.977 0.961 0.00 39 0.943 P46019 R186H Disease 0.947 0.936 0.00 30 0.913 P46019 R295H Disease 0.951 0.933 0.00 67 0.961 P46019 E1125K Disease 0.880 0.883 0.00 67 0.942 P46019 G1207W Disease 0.970 0.907 0.00 43 0.940 P46019 P1205L Disease 0.596 0.763 0.09 -1 0.573 P46019 T1114I Disease 0.775 0.911 0.01 47 0.876 P46020 D299V Disease 0.965 0.954 0.00 66 0.967 P46059 F28Y Polymorphism 0.719 0.635 0.00 36 0.700 P46059 V21I Polymorphism 0.102 0.199 0.09 -7 0.201 P46059 S117N Polymorphism 0.077 0.175 0.90 -37 0.078 P46059 V122M Polymorphism 0.424 0.313 0.06 -39 0.320 P46063 K487T Polymorphism 0.146 0.273 0.05 -16 0.254 P46063 V102I Polymorphism 0.146 0.112 0.51 2 0.131 P46087 L73S Polymorphism NA 0.178 NA 10 0.046 P46098 A33T Polymorphism NA 0.280 0.04 -19 0.312 P46098 R344H Polymorphism 0.570 0.666 0.39 6 0.486 P46098 R409Q Polymorphism 0.388 0.114 0.56 10 0.158 P46100 C200S Disease 0.369 0.889 0.00 48 0.793 P46100 C220R Disease 0.595 0.815 0.00 56 0.886 P46100 C220Y Disease 0.661 0.800 0.00 31 0.849 P46100 C243F Disease 0.603 0.867 0.00 43 0.843 P46100 G175E Disease NA 0.500 0.00 68 0.862 P46100 G249C Disease NA 0.655 0.00 39 0.729 P46100 G249D Disease NA 0.621 0.00 58 0.751 P46100 L192F Disease NA 0.603 0.11 14 0.677 P46100 L409S Disease NA 0.500 0.00 33 0.718 P46100 N179S Disease NA 0.500 0.01 18 0.469 P46100 P190A Disease NA 0.523 0.00 -6 0.476 P46100 P190L Disease NA 0.639 0.00 -6 0.476 P46100 P190S Disease NA 0.661 0.00 -49 0.472 P46100 Q219P Disease 0.508 0.438 0.01 33 0.616 P46100 Q545E Polymorphism NA 0.160 0.00 -12 0.350 P46100 R246C Disease NA 0.840 0.00 26 0.788 P46100 R246L Disease NA 0.697 0.01 39 0.762 P46100 V194I Disease 0.145 0.507 0.01 -3 0.348 P46100 W222S Disease 0.565 0.769 0.00 46 0.838 P46100 C1614R Disease 0.580 0.693 0.26 53 0.617 P46100 D2035V Disease 0.547 0.877 0.03 39 0.870 P46100 H1609R Disease 0.349 0.293 0.18 57 0.528 P46100 I2050T Disease 0.369 0.460 0.00 38 0.568 P46100 K1650N Disease NA 0.121 0.21 61 0.266 P46100 L1645S Disease NA 0.268 0.02 35 0.394 P46100 P1713S Disease 0.415 0.360 0.11 36 0.441 P46100 R1742K Disease 0.721 0.519 0.05 49 0.716 P46100 R2131Q Disease 0.825 0.817 0.08 57 0.921 P46100 R2271G Disease 0.451 0.378 0.00 32 0.477 P46100 T1621M Disease 0.540 0.241 0.12 44 0.593 P46100 V1538G Disease NA 0.693 0.24 18 0.748 P46100 V1552F Disease 0.675 0.725 0.04 51 0.888 P46100 Y1847C Disease 0.967 0.939 0.00 61 0.958 P46100 Y2084H Disease 0.457 0.390 0.17 62 0.693 P46100 Y2163C Disease 0.966 0.930 0.00 58 0.948 P46199 T59N Polymorphism 0.239 0.116 0.28 10 0.099 P46199 V556I Polymorphism NA 0.067 1.00 -42 0.032 P46379 A728V Polymorphism 0.335 0.131 0.06 19 0.123 P46379 S625P Polymorphism 0.106 0.154 1.00 -27 0.011 P46439 L179P Polymorphism 0.149 0.258 1.00 8 0.060 P46459 T476M Polymorphism 0.677 0.337 0.05 0 0.595 P46527 R15W Polymorphism 0.882 0.467 0.00 51 0.762 P46527 V109G Polymorphism 0.230 0.177 0.09 16 0.153 P46531 R879W Polymorphism NA 0.200 0.10 48 0.419 P46531 V1671I Polymorphism NA 0.222 0.47 10 0.263 P46597 N17K Polymorphism NA 0.566 0.19 29 0.610 P46663 A250V Polymorphism 0.403 0.443 0.17 -32 0.211 P46663 R317Q Polymorphism 0.160 0.363 0.17 -22 0.157 P46721 I13T Polymorphism NA 0.216 0.69 -34 0.145 P46721 A187T Polymorphism 0.381 0.371 0.02 36 0.420 P46734 A84T Polymorphism 0.111 0.438 0.30 -39 0.149 P46734 M90I Polymorphism 0.171 0.577 0.70 14 0.236 P46734 P40T Polymorphism NA 0.391 0.58 4 0.422 P46734 R26T Polymorphism NA 0.120 0.57 0 0.156 P46734 R94L Polymorphism 0.825 0.617 0.47 11 0.761 P46734 R96W Polymorphism 0.758 0.797 0.00 29 0.815 P46734 S68P Polymorphism 0.218 0.662 0.26 -3 0.447 P46734 R293H Polymorphism 0.224 0.195 0.18 2 0.198 P46734 V339M Polymorphism 0.714 0.390 0.10 5 0.618 P46777 A285V Disease 0.110 0.426 0.00 8 0.275 P46777 G140S Disease 0.254 0.704 0.12 -12 0.463 P46777 Y210C Polymorphism 0.355 0.166 0.06 9 0.251 P46821 P1296L Polymorphism 0.068 0.172 0.52 -10 0.115 P46821 S1917R Polymorphism 0.266 0.091 0.08 9 0.075 P46939 N2202S Polymorphism 0.206 0.053 0.71 -13 0.073 P46940 S256A Polymorphism 0.109 0.062 1.00 -1 0.031 P47211 P342L Polymorphism 0.155 0.283 0.06 0 0.262 P47712 V224I Polymorphism 0.171 0.064 1.00 16 0.029 P47736 A107T Polymorphism 0.397 0.364 0.10 29 0.239 P47804 S66R Disease 0.340 0.419 0.01 48 0.604 P47804 H152N Polymorphism 0.163 0.310 0.16 21 0.237 P47804 V132L Polymorphism 0.190 0.480 0.53 -24 0.293 P47871 P114A Polymorphism NA 0.145 0.41 17 0.239 P47874 G36R Polymorphism 0.528 0.164 NA 44 0.236 P47874 R26W Polymorphism 0.924 0.500 NA 53 0.892 P47881 S78G Polymorphism 0.361 0.723 0.00 41 0.790 P47881 R125Q Polymorphism 0.302 0.887 0.01 59 0.897 P47887 C27R Polymorphism 0.207 0.852 0.00 41 0.746 P47888 W158L Polymorphism 0.147 0.828 0.07 55 0.644 P47895 M386V Polymorphism 0.368 0.191 0.54 -4 0.104 P47901 K65N Polymorphism 0.780 0.822 0.01 58 0.891 P47901 G191R Polymorphism 0.106 0.821 0.65 35 0.206 P47901 R364H Polymorphism 0.070 0.310 0.15 -3 0.226 P47944 G48D Polymorphism 0.207 0.295 0.14 49 0.106 P47989 D584A Polymorphism 0.128 0.208 0.78 -28 0.148 P47989 K617N Polymorphism 0.608 0.600 0.20 9 0.529 P47989 P555S Polymorphism 0.302 0.266 0.47 -41 0.270 P47989 R149C Disease 0.994 0.965 0.00 75 0.958 P47989 T235M Polymorphism 0.216 0.306 0.28 17 0.327 P47989 T623I Polymorphism 0.201 0.485 0.56 -7 0.215 P47989 T910M Polymorphism 0.778 0.842 0.00 55 0.921 P47989 N1109T Polymorphism 0.193 0.099 0.63 -12 0.211 P47989 R1176C Polymorphism 0.766 0.921 0.00 40 0.873 P47989 V1091L Polymorphism 0.275 0.727 0.02 17 0.547 P48029 T164S Polymorphism 0.143 0.349 0.08 -36 0.246 P48039 A157V Polymorphism 0.218 0.132 0.87 -22 0.128 P48039 I212T Polymorphism 0.341 0.284 0.68 5 0.337 P48048 D74Y Disease 0.631 0.945 0.00 45 0.887 P48048 V72E Disease 0.516 0.670 0.00 35 0.797 P48048 W99C Disease 0.836 0.967 0.00 16 0.856 P48048 A198T Disease 0.964 0.880 0.00 46 0.923 P48048 A214V Disease 0.680 0.610 0.00 10 0.789 P48048 D108H Disease 0.992 0.980 0.00 63 0.956 P48048 G167E Disease 0.618 0.922 0.00 57 0.920 P48048 M357T Disease 0.167 0.158 0.14 10 0.221 P48048 N124K Disease 0.226 0.868 0.26 9 0.444 P48048 P110L Disease 0.081 0.403 0.30 -26 0.217 P48048 S219R Disease 0.391 0.952 0.00 33 0.682 P48048 V122E Disease 0.458 0.935 0.00 46 0.877 P48048 V315G Disease 0.598 0.837 0.00 23 0.665 P48145 Y135F Polymorphism 0.930 0.638 0.00 32 0.856 P48165 E48K Disease 0.455 0.960 0.00 67 0.935 P48165 P88S Disease 0.590 0.937 0.00 51 0.899 P48165 V44E Disease 0.692 0.957 0.02 63 0.939 P48165 V64G Disease 0.920 0.962 0.00 53 0.946 P48165 I247M Disease 0.312 0.068 0.15 10 0.135 P48165 R198Q Disease 0.515 0.927 0.01 55 0.906 P48167 G251D Disease 0.380 0.833 0.00 51 0.887 P48304 R109H Polymorphism 0.631 0.279 0.22 5 0.548 P48307 R231Q Polymorphism 0.032 0.080 NA 37 0.081 P48307 V102A Polymorphism 0.135 0.063 0.35 12 0.111 P48357 D124G Polymorphism NA 0.157 1.00 1 0.030 P48357 K656N Polymorphism 0.335 0.204 0.12 42 0.246 P48357 S675T Polymorphism 0.427 0.189 0.18 26 0.336 P48357 T699M Polymorphism 0.730 0.657 0.02 60 0.862 P48378 R610Q Polymorphism 0.344 0.340 0.56 38 0.357 P48382 P409R Polymorphism NA 0.097 NA 35 0.080 P48382 P499S Polymorphism NA 0.151 NA 20 0.134 P48382 R149Q Disease 0.976 0.825 0.02 69 0.954 P48382 R197Q Polymorphism 0.094 0.191 NA 4 0.160 P48426 L7I Polymorphism NA 0.060 0.54 0 0.040 P48426 N251S Polymorphism 0.114 0.128 0.71 2 0.109 P48436 A119V Disease 0.892 0.881 0.08 35 0.878 P48436 A158T Disease 0.844 0.876 0.00 40 0.860 P48436 F112L Disease 0.831 0.895 0.00 61 0.932 P48436 F112S Disease 0.944 0.910 0.00 63 0.940 P48436 F154L Disease 0.833 0.876 0.01 42 0.860 P48436 H165Y Disease 0.925 0.907 0.03 55 0.933 P48436 P108L Disease 0.965 0.891 0.00 56 0.944 P48436 P170R Disease 0.999 0.874 0.00 54 0.942 P48436 R152P Disease 0.945 0.896 0.01 46 0.911 P48436 W143R Disease 0.999 0.885 0.00 72 0.945 P48444 F186L Polymorphism 0.193 0.352 0.72 15 0.240 P48448 A50T Polymorphism 0.841 0.871 0.13 53 0.910 P48448 R276W Polymorphism 0.860 0.801 0.00 33 0.791 P48449 H310R Polymorphism NA 0.129 0.38 8 0.168 P48449 P688L Polymorphism NA 0.532 0.13 4 0.486 P48449 R614W Polymorphism NA 0.919 0.00 51 0.905 P48506 L55S Polymorphism 0.350 0.742 0.01 30 0.715 P48506 H370L Disease 0.718 0.961 0.00 54 0.902 P48506 P158L Disease 0.499 0.819 0.26 39 0.736 P48506 R127C Disease 0.943 0.950 0.00 62 0.951 P48507 I209M Polymorphism 0.630 0.684 0.00 43 0.770 P48509 K132R Polymorphism 0.159 0.713 0.50 -15 0.236 P48509 T120M Polymorphism 0.515 0.515 0.02 0 0.520 P48551 I196V Polymorphism 0.120 0.050 1.00 -13 0.045 P48552 N567S Polymorphism 0.202 0.134 NA 9 0.157 P48552 R448G Polymorphism 0.596 0.278 NA 41 0.510 P48552 Y315F Polymorphism 0.062 0.029 NA -25 0.018 P48552 V1079F Polymorphism 0.461 0.100 NA 45 0.080 P48553 I633M Polymorphism 0.343 0.205 0.10 27 0.231 P48553 V726M Polymorphism 0.519 0.075 0.16 -4 0.077 P48595 S3A Polymorphism NA 0.372 0.57 -48 0.268 P48595 I41M Polymorphism NA 0.078 1.00 -38 0.042 P48595 D360N Polymorphism 0.058 0.417 0.83 -27 0.135 P48595 G135D Polymorphism 0.599 0.658 1.00 -14 0.424 P48634 D82V Polymorphism 0.901 0.876 0.00 22 0.897 P48634 G1285A Polymorphism 0.250 0.101 0.82 -1 0.062 P48634 G1544D Polymorphism 0.464 0.192 0.00 13 0.231 P48634 G1744A Polymorphism NA 0.157 0.00 12 0.228 P48634 P2006S Polymorphism NA 0.199 0.00 29 0.098 P48634 P2130L Polymorphism NA 0.213 0.00 21 0.156 P48634 R2075W Polymorphism NA 0.223 0.00 38 0.275 P48634 V1774M Polymorphism NA 0.058 0.00 14 0.137 P48634 V1775M Polymorphism NA 0.082 0.00 10 0.164 P48637 A26D Disease 0.868 0.812 0.01 31 0.871 P48637 D219A Disease 0.812 0.813 0.00 60 0.927 P48637 D219G Disease 0.808 0.898 0.00 59 0.932 P48637 D469E Disease 0.684 0.917 0.03 61 0.926 P48637 G464V Disease 0.974 0.918 0.00 68 0.960 P48637 L188P Disease 0.469 0.953 0.01 47 0.873 P48637 L254R Disease 0.727 0.968 0.00 56 0.922 P48637 L286Q Disease 0.909 0.762 0.01 19 0.867 P48637 R267W Disease 0.987 0.975 0.00 67 0.960 P48637 R283C Disease 0.973 0.946 0.00 59 0.958 P48637 R330C Disease 0.813 0.466 0.02 16 0.655 P48637 Y270C Disease 0.980 0.947 0.00 71 0.959 P48637 Y270H Disease 0.929 0.951 0.00 77 0.947 P48643 E146V Polymorphism 0.316 0.591 0.00 0 0.453 P48643 H147R Disease 0.170 0.267 0.17 -30 0.165 P48651 T423N Polymorphism 0.173 0.161 0.52 16 0.122 P48668 R182Q Polymorphism 0.606 0.919 0.02 8 0.630 P48668 S227N Polymorphism 0.346 0.357 0.53 -50 0.211 P48668 V481I Polymorphism 0.398 0.183 0.42 -15 0.183 P48681 V815I Polymorphism NA 0.058 0.05 -7 0.076 P48681 P1101L Polymorphism NA 0.103 NA -15 0.019 P48681 P1275L Polymorphism NA 0.088 NA -45 0.008 P48728 G47R Disease 0.872 0.943 0.01 49 0.921 P48728 H42R Disease 0.890 0.885 0.01 60 0.921 P48728 D276H Disease 0.865 0.827 0.00 62 0.900 P48728 E211K Disease 0.173 0.379 0.64 22 0.240 P48728 G269D Disease 0.710 0.899 0.01 68 0.872 P48728 N145I Disease 0.970 0.907 0.00 59 0.936 P48728 R320H Disease 0.830 0.682 0.03 57 0.912 P48730 T44A Disease 0.249 0.125 0.38 -50 0.149 P48740 G679R Polymorphism 0.982 0.802 0.01 68 0.946 P48740 V568A Polymorphism 0.573 0.450 0.01 51 0.650 P48745 R233H Polymorphism 0.271 0.298 0.14 -11 0.307 P48751 S226L Polymorphism 0.340 0.122 0.01 0 0.170 P48788 R174Q Disease 0.838 0.745 0.00 56 0.919 P49005 N303S Polymorphism 0.228 0.585 0.45 4 0.369 P49019 G350S Polymorphism 0.095 0.230 0.59 -11 0.166 P49019 M346I Polymorphism 0.133 0.140 0.28 39 0.172 P49019 P173T Polymorphism 0.304 0.176 0.36 -36 0.194 P49019 R253H Polymorphism 0.394 0.510 0.52 -19 0.342 P49069 V78I Polymorphism 0.062 0.064 NA -7 0.024 P49069 G100S Polymorphism 0.063 0.142 NA 16 0.062 P49137 A173G Polymorphism 0.559 0.529 0.03 -3 0.311 P49184 V122I Polymorphism 0.067 0.107 0.49 -8 0.126 P49189 C116S Polymorphism 0.231 0.274 0.20 -1 0.291 P49221 E100D Polymorphism NA 0.122 0.57 -13 0.207 P49221 R372C Polymorphism 0.812 0.862 0.00 44 0.892 P49221 R372H Polymorphism 0.487 0.589 0.02 15 0.715 P49221 V409I Polymorphism 0.131 0.092 1.00 -37 0.086 P49221 Y244H Polymorphism 0.500 0.279 0.54 -7 0.373 P49223 L77S Polymorphism 0.184 0.396 0.66 -9 0.068 P49238 E13D Polymorphism 0.232 0.314 1.00 -5 0.261 P49238 T57A Polymorphism 0.211 0.120 0.42 -41 0.153 P49238 T280M Polymorphism 0.633 0.379 0.03 0 0.599 P49238 V122I Polymorphism 0.147 0.193 0.27 -30 0.169 P49238 V147I Polymorphism 0.147 0.152 0.44 -48 0.129 P49247 A135V Disease 0.549 0.610 0.01 29 0.757 P49257 R14Q Polymorphism NA 0.120 0.47 12 0.105 P49257 V39A Polymorphism NA 0.043 0.65 -23 0.038 P49279 A318V Polymorphism 0.255 0.247 0.27 -26 0.280 P49281 E399D Disease 0.651 0.711 0.02 5 0.742 P49281 G212V Disease 0.398 0.600 0.29 -55 0.368 P49281 L435I Polymorphism 0.347 0.588 0.53 -32 0.423 P49281 R416C Disease 0.988 0.872 0.00 59 0.939 P49286 L66F Polymorphism 0.151 0.626 0.67 -2 0.156 P49286 R231H Polymorphism 0.679 0.551 0.12 8 0.642 P49326 P400A Polymorphism 0.935 0.784 0.03 27 0.855 P49326 P457L Polymorphism 0.511 0.768 0.00 20 0.679 P49326 R506S Polymorphism 0.143 0.298 0.63 0 0.078 P49327 I1888V Polymorphism 0.174 0.299 0.11 -16 0.150 P49327 R1694H Polymorphism 0.507 0.702 0.07 -2 0.608 P49327 V1483I Polymorphism 0.168 0.065 0.56 -29 0.089 P49335 A312V Disease 0.865 0.884 0.00 33 0.888 P49335 K334E Disease 0.971 0.932 0.00 64 0.956 P49335 L317W Disease 0.967 0.912 0.00 60 0.948 P49335 R323G Disease 0.907 0.943 0.00 45 0.910 P49335 R330S Disease 0.380 0.910 0.00 71 0.913 P49366 E174D Polymorphism 0.164 0.236 1.00 -36 0.220 P49368 L391F Polymorphism 0.627 0.794 0.01 -18 0.573 P49411 R336Q Disease 0.904 0.936 0.00 74 0.933 P49418 M376I Polymorphism 0.096 0.175 0.24 -6 0.113 P49427 D227H Polymorphism NA 0.099 0.00 26 0.173 P49441 T228A Polymorphism 0.195 0.165 0.77 25 0.122 P49448 S498A Polymorphism 0.149 0.058 0.42 -35 0.091 P49454 D272G Polymorphism 0.076 0.142 0.14 27 0.118 P49454 Q250L Polymorphism 0.223 0.144 0.30 18 0.134 P49454 Q754E Polymorphism 0.284 0.202 1.00 12 0.138 P49454 R815H Polymorphism 0.366 0.025 0.15 -28 0.010 P49454 A1515T Polymorphism 0.238 0.031 0.30 -38 0.010 P49454 D1864N Polymorphism NA 0.087 0.18 19 0.033 P49454 E2011A Polymorphism NA 0.306 0.37 34 0.286 P49454 G1033R Polymorphism 0.511 0.074 0.51 42 0.063 P49454 K1539R Polymorphism 0.166 0.305 0.79 -1 0.262 P49454 L1412S Polymorphism 0.433 0.039 0.55 -21 0.025 P49454 N3202K Polymorphism NA 0.016 NA -24 0.025 P49454 T1105I Polymorphism 0.286 0.112 0.03 11 0.049 P49454 Y1018D Polymorphism 0.498 0.583 0.18 53 0.690 P49619 R370W Polymorphism 0.783 0.781 0.01 63 0.904 P49619 T142S Polymorphism NA 0.062 0.27 -17 0.059 P49638 R59W Disease NA 0.799 0.00 53 0.886 P49638 A120T Disease 0.209 0.644 0.34 12 0.346 P49638 E141K Disease 0.996 0.897 0.00 68 0.937 P49638 G246R Disease 0.597 0.869 0.00 64 0.907 P49638 H101Q Disease 0.022 0.385 0.25 29 0.137 P49638 R192H Disease 0.577 0.533 0.10 1 0.491 P49638 R221W Disease 0.836 0.915 0.00 59 0.939 P49641 Q412R Polymorphism 0.215 0.172 0.57 -8 0.132 P49643 C287Y Polymorphism 0.740 0.971 0.00 60 0.945 P49643 D435G Polymorphism 0.168 0.723 0.42 -9 0.321 P49643 G259S Polymorphism 0.393 0.549 0.45 -5 0.433 P49643 Q265L Polymorphism 0.363 0.471 0.51 -3 0.316 P49643 Q446H Polymorphism 0.591 0.321 0.07 22 0.587 P49675 A218V Disease 0.440 0.393 0.02 38 0.535 P49675 E169G Disease 0.528 0.346 0.05 46 0.577 P49675 E169K Disease 0.447 0.418 0.10 46 0.564 P49675 L275P Disease 0.725 0.706 0.01 48 0.859 P49675 M225T Disease 0.391 0.351 0.35 37 0.486 P49675 R182L Disease 0.981 0.979 0.00 67 0.966 P49675 R217T Disease 0.972 0.955 0.00 74 0.966 P49682 R292Q Polymorphism 0.188 0.269 0.33 23 0.181 P49683 D302G Polymorphism 0.958 0.463 0.44 35 0.802 P49685 M112V Polymorphism 0.195 0.120 0.31 16 0.169 P49736 A396T Polymorphism 0.258 0.396 0.09 19 0.475 P49736 E166Q Polymorphism NA 0.316 0.10 -13 0.379 P49736 L135F Polymorphism NA 0.189 0.06 9 0.272 P49746 S279G Polymorphism 0.209 0.457 0.35 -7 0.337 P49747 C328R Disease 0.971 0.964 0.00 73 0.960 P49747 C348R Disease 0.971 0.953 0.00 65 0.960 P49747 C371S Disease 0.932 0.836 0.00 55 0.921 P49747 C387G Disease 0.782 0.963 0.00 57 0.930 P49747 C468Y Disease 0.980 0.814 0.00 63 0.950 P49747 D290N Disease 0.897 0.930 0.01 43 0.874 P49747 D342Y Disease 0.976 0.973 0.00 62 0.961 P49747 D349V Disease 0.969 0.884 0.02 51 0.953 P49747 D361V Disease 0.969 0.859 0.01 50 0.949 P49747 D361Y Disease 0.976 0.937 0.00 54 0.959 P49747 D408Y Disease 0.977 0.970 0.00 58 0.952 P49747 D420A Disease 0.926 0.906 0.00 53 0.925 P49747 D472Y Disease 0.969 0.805 0.00 -6 0.829 P49747 D473G Disease 0.914 0.831 0.06 51 0.917 P49747 D482G Disease 0.915 0.956 0.00 57 0.942 P49747 D518N Disease 0.902 0.919 0.00 36 0.907 P49747 G299R Disease 0.970 0.931 0.01 52 0.956 P49747 G440E Disease 0.963 0.849 0.00 47 0.939 P49747 G440R Disease 0.971 0.861 0.00 56 0.953 P49747 G719D Disease 0.961 0.971 0.00 62 0.972 P49747 N453S Disease 0.901 0.902 0.00 46 0.832 P49747 N523K Disease 0.571 0.833 0.00 47 0.854 P49747 P276R Disease 0.969 0.903 0.04 51 0.949 P49747 T585M Disease 0.733 0.914 0.00 33 0.853 P49747 T585R Disease 0.594 0.958 0.00 59 0.918 P49748 G43D Disease NA 0.142 0.64 47 0.154 P49748 L17F Polymorphism NA 0.196 0.00 23 0.104 P49748 A213P Disease 0.949 0.938 0.01 52 0.922 P49748 A281D Disease 0.965 0.939 0.01 59 0.925 P49748 A490P Disease 0.767 0.711 0.11 16 0.812 P49748 D405H Disease 0.906 0.909 0.00 55 0.878 P49748 D454N Disease 0.785 0.867 0.06 61 0.764 P49748 E218K Disease 0.954 0.908 0.00 81 0.912 P49748 E534K Disease 0.229 0.091 0.28 -36 0.146 P49748 F458L Disease 0.376 0.183 0.65 -4 0.147 P49748 G185S Disease 0.762 0.693 0.57 54 0.810 P49748 G290D Disease 0.970 0.929 0.00 75 0.924 P49748 G294E Disease 0.642 0.923 0.17 45 0.656 P49748 G441D Disease 0.989 0.927 0.00 75 0.930 P49748 G463E Disease 0.993 0.865 0.00 81 0.926 P49748 K247E Disease 0.998 0.918 0.00 66 0.942 P49748 K247T Disease 0.998 0.901 0.00 62 0.941 P49748 K299N Disease 0.820 0.925 0.14 64 0.892 P49748 K382Q Disease 0.720 0.626 0.13 10 0.642 P49748 L243R Disease 0.989 0.814 0.00 67 0.929 P49748 L502P Disease 0.692 0.866 0.03 32 0.808 P49748 L602I Disease 0.508 0.698 0.00 0 0.539 P49748 M352V Disease 0.404 0.634 0.51 2 0.392 P49748 Q159R Disease NA 0.624 0.54 37 0.785 P49748 R366C Disease 0.995 0.908 0.00 72 0.889 P49748 R366H Disease 0.984 0.873 0.00 73 0.836 P49748 R450H Disease 0.914 0.833 0.00 39 0.851 P49748 R453Q Disease 0.694 0.896 0.01 74 0.872 P49748 R456H Disease 0.907 0.739 0.00 58 0.915 P49748 R459W Disease 0.970 0.845 0.01 59 0.924 P49748 R469Q Disease 0.784 0.878 0.04 27 0.735 P49748 R469W Disease 0.975 0.952 0.00 48 0.932 P49748 R613W Disease 0.937 0.880 0.00 35 0.901 P49748 R615Q Disease 0.229 0.112 0.28 -23 0.140 P49748 S623F Polymorphism 0.910 0.494 0.00 -21 0.755 P49748 T158N Disease NA 0.449 0.10 27 0.439 P49748 T260M Disease 0.792 0.621 0.08 34 0.776 P49748 V174M Disease 0.681 0.642 0.02 0 0.722 P49748 V283A Disease 0.670 0.466 0.01 24 0.689 P49748 V317A Disease 0.947 0.739 0.00 52 0.914 P49754 R843H Polymorphism 0.356 0.234 NA 28 0.165 P49754 T146P Polymorphism 0.489 0.664 0.17 31 0.753 P49755 S64Y Polymorphism 0.202 0.677 0.14 -15 0.317 P49757 V387I Polymorphism 0.398 0.105 0.29 11 0.074 P49759 N99D Polymorphism 0.146 0.086 0.40 10 0.066 P49759 S61F Polymorphism 0.563 0.437 0.49 -10 0.513 P49759 E459G Polymorphism NA 0.262 0.08 2 0.373 P49759 P307S Polymorphism NA 0.472 0.51 -22 0.360 P49759 R118G Polymorphism 0.345 0.476 0.05 46 0.608 P49761 Q607R Polymorphism NA 0.396 0.19 -6 0.191 P49761 R486C Polymorphism 0.975 0.863 0.00 79 0.937 P49768 A79V Disease 0.726 0.733 0.01 15 0.679 P49768 C92S Disease 0.830 0.936 0.04 45 0.884 P49768 V82L Disease 0.508 0.857 0.15 -6 0.532 P49768 V96F Disease 0.824 0.939 0.00 37 0.826 P49768 A231T Disease 0.661 0.532 0.10 9 0.663 P49768 A231V Disease 0.726 0.453 0.68 -10 0.506 P49768 A246E Disease 0.450 0.777 0.03 17 0.769 P49768 A260V Disease 0.777 0.937 0.00 35 0.744 P49768 A285V Disease 0.777 0.884 0.00 32 0.862 P49768 A409T Disease 0.712 0.905 0.13 -6 0.679 P49768 A426P Disease 0.813 0.811 0.01 29 0.843 P49768 A431E Disease 0.857 0.858 0.00 45 0.888 P49768 C263R Disease 0.510 0.912 0.01 34 0.837 P49768 C410Y Disease 0.907 0.988 0.00 46 0.919 P49768 E120D Disease 0.569 0.526 0.29 -1 0.454 P49768 E120K Disease 0.699 0.563 0.15 14 0.659 P49768 E280A Disease 0.452 0.827 0.01 16 0.579 P49768 E280G Disease 0.495 0.766 0.00 33 0.787 P49768 E318G Polymorphism 0.207 0.164 0.30 7 0.236 P49768 F105L Disease 0.604 0.825 0.27 11 0.557 P49768 G206A Disease 0.764 0.860 0.11 -8 0.674 P49768 G209R Disease 0.926 0.991 0.00 59 0.947 P49768 G209V Disease 0.920 0.989 0.00 15 0.905 P49768 G266S Disease 0.837 0.933 0.00 37 0.886 P49768 G378E Disease 0.875 0.912 0.01 52 0.896 P49768 G384A Disease 0.864 0.962 0.00 52 0.936 P49768 H163R Disease 0.197 0.728 0.12 -10 0.416 P49768 H163Y Disease 0.395 0.733 0.31 -33 0.436 P49768 I143F Disease 0.677 0.815 0.00 13 0.690 P49768 I143T Disease 0.674 0.703 0.00 16 0.834 P49768 I213T Disease 0.739 0.910 0.00 21 0.852 P49768 L113P Disease 0.909 0.955 0.00 9 0.894 P49768 L166P Disease 0.909 0.984 0.00 42 0.905 P49768 L171P Disease 0.763 0.911 0.02 29 0.846 P49768 L173W Disease 0.935 0.805 0.00 17 0.865 P49768 L174M Disease 0.712 0.691 0.00 21 0.772 P49768 L219P Disease 0.909 0.957 0.02 -21 0.860 P49768 L250S Disease 0.890 0.947 0.00 26 0.901 P49768 L262F Disease 0.736 0.883 0.00 33 0.858 P49768 L271V Disease 0.654 0.847 0.00 38 0.708 P49768 L282R Disease 0.672 0.882 0.00 24 0.866 P49768 L286V Disease 0.624 0.836 0.01 43 0.851 P49768 L392V Disease 0.624 0.810 0.00 43 0.831 P49768 M139I Disease 0.479 0.271 0.11 -36 0.264 P49768 M139K Disease 0.752 0.683 0.01 26 0.749 P49768 M139T Disease 0.698 0.400 0.01 12 0.606 P49768 M139V Disease 0.497 0.290 0.20 -24 0.260 P49768 M146I Disease 0.575 0.686 0.16 16 0.567 P49768 M146L Disease 0.408 0.810 0.12 -8 0.521 P49768 M146V Disease 0.595 0.642 0.47 -12 0.435 P49768 M233L Disease 0.406 0.743 0.06 -38 0.500 P49768 M233T Disease 0.772 0.684 0.01 -22 0.674 P49768 N135D Disease 0.700 0.925 0.04 40 0.724 P49768 N405S Disease 0.401 0.632 0.75 -7 0.407 P49768 P117L Disease 0.894 0.772 0.11 11 0.787 P49768 P264L Disease 0.918 0.959 0.00 37 0.903 P49768 P267S Disease 0.862 0.902 0.00 38 0.879 P49768 P267T Disease 0.891 0.910 0.00 39 0.904 P49768 P436Q Disease 0.959 0.917 0.00 32 0.928 P49768 P436S Disease 0.905 0.854 0.00 22 0.904 P49768 R269G Disease 0.838 0.866 0.00 34 0.868 P49768 R269H Disease 0.876 0.887 0.01 21 0.836 P49768 R278T Disease 0.861 0.923 0.00 51 0.930 P49768 S169L Disease 0.829 0.949 0.00 29 0.882 P49768 S169P Disease 0.818 0.981 0.01 56 0.933 P49768 S289C Disease 0.857 0.872 0.01 33 0.864 P49768 S390I Disease 0.918 0.970 0.00 54 0.943 P49768 T116N Disease 0.798 0.793 0.05 31 0.660 P49768 T147I Disease 0.836 0.933 0.00 7 0.870 P49768 W165C Disease 0.951 0.902 0.00 47 0.927 P49768 Y115C Disease 0.936 0.943 0.01 51 0.943 P49768 Y115H Disease 0.799 0.883 0.01 58 0.927 P49770 E213G Disease 0.446 0.755 0.06 -9 0.631 P49770 G329V Disease 0.720 0.950 0.00 64 0.940 P49770 K273R Disease 0.564 0.798 0.08 39 0.734 P49770 S171F Disease 0.899 0.911 0.01 66 0.933 P49770 V316D Disease 0.901 0.878 0.01 53 0.924 P49790 D90N Polymorphism 0.136 0.091 NA 17 0.113 P49790 I248V Polymorphism NA 0.048 NA -36 0.067 P49790 N402K Polymorphism 0.129 0.034 NA -11 0.010 P49790 P821L Polymorphism 0.564 0.593 0.00 34 0.530 P49790 T1388A Polymorphism 0.181 0.061 0.16 -29 0.065 P49792 E580K Polymorphism NA 0.095 1.00 -10 0.033 P49792 V548L Polymorphism NA 0.114 0.90 17 0.065 P49792 P1892A Polymorphism NA 0.144 0.14 40 0.167 P49796 R129K Polymorphism NA 0.083 0.05 11 0.024 P49810 R62H Disease 0.112 0.287 0.12 -15 0.183 P49810 M239I Disease 0.573 0.666 0.06 -31 0.508 P49810 M239V Disease 0.593 0.467 0.32 -27 0.449 P49810 N141I Disease 0.905 0.939 0.00 31 0.883 P49810 T122P Disease 0.822 0.921 0.12 39 0.874 P49810 V148I Disease 0.392 0.418 0.09 -20 0.277 P49815 A536V Polymorphism 0.474 0.117 0.00 17 0.256 P49815 A583T Polymorphism 0.545 0.457 0.03 50 0.663 P49815 A607T Polymorphism 0.425 0.246 0.09 52 0.262 P49815 A614D Disease 0.661 0.349 0.01 51 0.600 P49815 A862V Polymorphism 0.491 0.086 0.15 33 0.165 P49815 C227Y Disease 0.257 0.570 0.03 55 0.725 P49815 C696Y Disease 0.924 0.381 0.01 49 0.628 P49815 D647N Disease 0.385 0.161 0.01 51 0.333 P49815 F615S Polymorphism 0.514 0.665 0.22 37 0.729 P49815 G294E Disease 0.658 0.473 0.01 65 0.839 P49815 G440S Polymorphism 0.299 0.190 0.00 23 0.293 P49815 H137R Disease NA 0.084 0.37 24 0.092 P49815 H593R Polymorphism 0.550 0.343 0.03 51 0.596 P49815 I463V Polymorphism 0.446 0.138 0.33 12 0.146 P49815 I490V Polymorphism NA 0.114 0.14 8 0.127 P49815 K258N Disease 0.472 0.359 0.02 34 0.258 P49815 K599M Disease 0.512 0.137 0.00 17 0.235 P49815 L160V Polymorphism NA 0.142 0.25 11 0.218 P49815 L292P Disease 0.914 0.638 0.00 61 0.925 P49815 L309Q Polymorphism 0.490 0.398 0.00 43 0.622 P49815 L361P Disease 0.172 0.637 0.02 53 0.400 P49815 L717R Disease 0.518 0.898 0.00 67 0.906 P49815 L826M Disease NA 0.178 0.04 25 0.175 P49815 M286T Polymorphism 0.210 0.295 0.01 12 0.231 P49815 M286V Polymorphism 0.256 0.156 0.02 33 0.244 P49815 M449I Disease 0.334 0.159 0.03 35 0.159 P49815 M895V Disease 0.318 0.230 0.35 37 0.344 P49815 N331K Disease 0.241 0.178 0.01 30 0.271 P49815 N486I Disease 0.466 0.124 0.01 26 0.267 P49815 N525S Disease 0.166 0.095 0.03 -5 0.103 P49815 P378L Polymorphism 0.178 0.166 0.00 20 0.253 P49815 P816L Disease 0.656 0.408 0.02 39 0.631 P49815 R261P Disease NA 0.668 0.06 56 0.755 P49815 R261W Polymorphism NA 0.483 0.01 41 0.656 P49815 R367Q Polymorphism 0.467 0.172 0.11 35 0.222 P49815 R611Q Disease 0.466 0.351 0.00 65 0.702 P49815 R611W Disease 0.811 0.418 0.00 65 0.832 P49815 R905Q Disease 0.646 0.553 0.00 64 0.903 P49815 R905W Disease 0.925 0.695 0.00 64 0.933 P49815 V769E Disease 0.245 0.455 0.01 59 0.650 P49815 V963M Disease 0.187 0.138 0.00 34 0.142 P49815 Y407D Disease 0.313 0.246 0.00 42 0.403 P49815 A1141V Polymorphism 0.176 0.058 1.00 -13 0.068 P49815 A1429S Polymorphism 0.319 0.069 0.19 -36 0.067 P49815 A1712E Disease 0.704 0.456 0.06 37 0.657 P49815 D1084E Disease 0.472 0.139 0.00 22 0.193 P49815 D1295V Disease 0.855 0.098 0.00 30 0.420 P49815 D1636N Polymorphism 0.266 0.214 0.12 -38 0.183 P49815 D1690Y Disease 0.847 0.730 0.00 37 0.837 P49815 E1783Q Disease 0.258 0.142 0.02 15 0.169 P49815 G1787S Polymorphism 0.306 0.037 0.52 -42 0.047 P49815 G1791S Polymorphism 0.230 0.174 0.06 24 0.176 P49815 H1620Y Disease 0.775 0.951 0.00 50 0.911 P49815 H1773P Disease 0.194 0.144 0.01 21 0.208 P49815 L1027P Disease 0.865 0.508 0.00 31 0.703 P49815 L1594M Disease 0.626 0.189 0.09 1 0.305 P49815 L1744P Disease 0.467 0.784 0.01 57 0.850 P49815 L1750F Disease 0.622 0.282 0.01 25 0.488 P49815 N1643I Disease 0.207 0.969 0.00 39 0.666 P49815 N1643K Disease 0.485 0.982 0.00 56 0.910 P49815 N1651S Disease 0.447 0.334 0.06 15 0.370 P49815 N1681K Disease 0.423 0.512 0.20 42 0.657 P49815 P1227L Disease 0.892 0.172 0.00 20 0.396 P49815 P1315S Disease 0.320 0.133 0.00 -10 0.168 P49815 P1450R Polymorphism 0.898 0.260 0.00 12 0.565 P49815 P1497R Disease 0.627 0.579 0.00 50 0.853 P49815 P1675L Disease 0.238 0.881 0.01 31 0.580 P49815 P1709L Disease 0.492 0.651 0.01 11 0.680 P49815 R1200W Disease 0.852 0.374 0.00 46 0.695 P49815 R1240W Disease 0.830 0.153 0.00 35 0.387 P49815 R1329H Disease 0.216 0.058 0.00 8 0.142 P49815 R1743P Disease 0.745 0.862 0.00 78 0.921 P49815 R1743Q Disease 0.524 0.705 0.00 67 0.879 P49815 S1282G Polymorphism 0.698 0.134 0.00 14 0.221 P49815 S1341R Polymorphism 0.343 0.109 0.00 -19 0.084 P49815 S1498N Disease 0.720 0.420 0.00 21 0.473 P49815 S1653F Disease 0.782 0.756 0.01 32 0.834 P49815 S1704T Disease 0.499 0.405 1.00 37 0.376 P49815 S1774T Polymorphism 0.190 0.164 1.00 -41 0.068 P49815 V1144M Disease 0.481 0.037 0.04 22 0.087 P49815 V1673L Polymorphism 0.235 0.807 0.04 4 0.500 P49815 Y1549C Disease 0.223 0.953 0.00 43 0.585 P49815 Y1650C Disease 0.857 0.562 0.00 38 0.801 P49821 I76V Polymorphism 0.240 0.267 0.39 -38 0.282 P49821 A341V Disease 0.539 0.661 0.18 32 0.791 P49821 N277Y Polymorphism 0.618 0.589 0.07 27 0.742 P49821 T423M Disease 0.823 0.890 0.00 57 0.924 P49842 A39D Polymorphism NA 0.409 NA 43 0.244 P49842 A331V Polymorphism NA 0.156 NA 0 0.115 P49842 S311G Polymorphism NA 0.279 NA 1 0.177 P49848 C36S Polymorphism NA 0.241 0.36 -16 0.134 P49902 T3A Polymorphism 0.232 0.125 0.00 -6 0.181 P49902 Q136R Polymorphism 0.391 0.191 0.62 -10 0.260 P49916 K898T Polymorphism 0.289 0.089 0.14 7 0.098 P49916 P986S Polymorphism NA 0.132 0.80 -32 0.065 P49916 R224W Polymorphism NA 0.153 0.01 38 0.159 P49917 T9I Polymorphism NA 0.214 0.06 7 0.315 P49917 D62H Polymorphism NA 0.726 0.05 55 0.795 P49917 A857T Polymorphism 0.278 0.127 0.42 -25 0.181 P49917 G469E Disease 0.816 0.754 0.00 64 0.915 P49917 L539F Polymorphism 0.561 0.352 0.20 21 0.536 P49917 R278H Disease 0.853 0.886 0.00 77 0.930 P49959 D468G Polymorphism 0.481 0.315 0.69 10 0.379 P49959 M157V Polymorphism 0.217 0.173 1.00 13 0.166 P49959 M698V Polymorphism 0.098 0.119 0.30 9 0.083 P49959 N117S Disease 0.666 0.946 0.00 38 0.737 P49961 V293I Polymorphism 0.213 0.106 0.45 -8 0.145 P50052 Y231H Polymorphism 0.875 0.540 0.00 59 0.872 P50053 A43T Disease 0.476 0.788 0.04 29 0.631 P50053 G40R Disease 0.794 0.949 0.00 78 0.939 P50148 E355D Polymorphism NA 0.152 0.75 -76 0.130 P50219 Q290P Disease 0.999 0.928 0.00 56 0.952 P50219 R245G Disease 0.993 0.946 0.00 68 0.953 P50219 R245H Disease 0.996 0.940 0.00 68 0.954 P50219 R292W Disease 0.999 0.901 0.00 74 0.943 P50219 R293Q Disease 0.999 0.894 0.00 76 0.947 P50219 R293W Disease 0.999 0.908 0.00 76 0.946 P50219 T246S Disease 0.653 0.744 0.00 50 0.894 P50219 W288G Disease 0.999 0.909 0.00 72 0.949 P50219 W288L Disease 0.999 0.850 0.00 72 0.942 P50225 E151D Polymorphism 0.087 0.455 1.00 -25 0.124 P50225 E151Q Polymorphism 0.245 0.542 0.57 -9 0.297 P50225 R213H Polymorphism 0.517 0.665 0.55 -19 0.522 P50226 Y62F Polymorphism 0.393 0.824 0.52 -23 0.572 P50281 A4T Polymorphism NA 0.104 0.15 -36 0.055 P50281 R6K Polymorphism NA 0.105 0.81 -44 0.048 P50281 I233V Polymorphism 0.068 0.779 0.01 -6 0.106 P50281 R431H Polymorphism 0.645 0.617 0.13 30 0.798 P50336 R59W Disease 0.555 0.764 0.01 66 0.892 P50336 G232R Disease 0.890 0.880 0.00 59 0.942 P50336 P256R Polymorphism 0.190 0.451 0.10 5 0.273 P50336 R152C Disease 0.774 0.934 0.00 66 0.942 P50336 R304H Polymorphism NA 0.261 0.10 -51 0.367 P50402 S54F Disease 0.600 0.115 0.01 -4 0.223 P50402 D149H Polymorphism 0.669 0.210 0.04 34 0.171 P50402 P183H Disease 0.799 0.146 0.04 36 0.359 P50402 P183T Disease 0.594 0.085 0.09 26 0.051 P50402 Q133H Disease 0.104 0.326 0.10 33 0.234 P50416 A275T Polymorphism 0.182 0.235 0.49 -15 0.154 P50416 A414V Disease 0.803 0.861 0.01 18 0.866 P50416 C304W Disease 0.969 0.875 0.08 62 0.941 P50416 D454G Disease 0.988 0.920 0.00 58 0.955 P50416 E360G Disease 0.581 0.350 0.15 11 0.604 P50416 F343V Disease 0.805 0.751 0.00 0 0.803 P50416 G465W Disease 0.979 0.949 0.00 65 0.952 P50416 G709E Disease 0.869 0.727 0.20 47 0.872 P50416 G710E Disease 0.783 0.869 0.08 37 0.843 P50416 L484P Disease 0.888 0.916 0.01 32 0.880 P50416 P479L Disease 0.535 0.414 1.00 29 0.577 P50416 R123C Disease NA 0.800 0.00 61 0.880 P50416 R316G Disease 0.906 0.893 0.00 60 0.933 P50416 R357W Disease 0.833 0.579 0.03 0 0.708 P50416 T314I Disease 0.772 0.572 0.01 32 0.781 P50416 Y498C Disease 0.870 0.705 0.11 14 0.808 P50440 Q110H Polymorphism 0.076 0.170 0.54 1 0.055 P50443 A715V Disease 0.675 0.918 0.00 6 0.869 P50443 C653S Disease 0.740 0.558 0.02 -7 0.745 P50443 G255E Disease 0.838 0.955 0.00 48 0.910 P50443 G678V Disease 0.565 0.572 0.08 16 0.746 P50443 I574T Polymorphism 0.297 0.264 0.56 -19 0.183 P50443 N425D Disease 0.605 0.859 0.03 60 0.900 P50443 R279W Disease 0.944 0.826 0.02 46 0.850 P50452 R68Q Polymorphism 0.080 0.098 0.54 -50 0.073 P50452 H359R Polymorphism 0.046 0.793 0.01 41 0.700 P50452 T304A Polymorphism 0.055 0.155 0.75 -46 0.068 P50454 A41P Polymorphism NA 0.619 0.05 23 0.486 P50461 W4R Disease 0.387 0.328 0.00 19 0.479 P50461 C58G Disease 0.893 0.926 0.00 66 0.949 P50461 L44P Disease 0.951 0.848 0.00 62 0.945 P50479 G259C Polymorphism 0.951 0.500 0.00 17 0.832 P50479 R142C Polymorphism 0.465 0.134 0.07 46 0.298 P50502 M297I Polymorphism 0.106 0.155 0.12 19 0.123 P50539 E152A Disease 0.345 0.131 0.48 23 0.208 P50542 N526K Disease 0.790 0.942 0.04 52 0.917 P50542 S600W Disease 0.771 0.906 0.00 51 0.905 P50552 Q140H Polymorphism 0.587 0.151 0.57 36 0.386 P50570 A618T Disease 0.629 0.559 0.25 -2 0.650 P50570 E368K Disease 0.536 0.839 0.49 45 0.720 P50570 K562E Disease 0.698 0.738 0.06 49 0.840 P50570 R369Q Disease 0.469 0.614 0.42 50 0.519 P50570 R369W Disease 0.940 0.741 0.10 50 0.914 P50570 R465W Disease 0.858 0.874 0.01 18 0.872 P50570 S619L Disease 0.869 0.827 0.03 5 0.851 P50570 S619W Disease 0.978 0.824 0.00 35 0.910 P50591 D47E Polymorphism 0.170 0.036 0.48 -49 0.049 P50591 V33I Polymorphism 0.179 0.219 0.28 -24 0.192 P50613 G163A Polymorphism 0.637 0.500 0.30 -6 0.583 P50613 T285M Polymorphism NA 0.783 0.00 36 0.841 P50616 K319R Polymorphism 0.279 0.204 0.16 40 0.327 P50747 E42D Disease NA 0.060 NA 1 0.063 P50747 D571N Disease 0.969 0.908 0.00 63 0.960 P50747 D615Y Disease 0.777 0.710 0.02 41 0.840 P50747 D634N Disease 0.371 0.234 0.22 31 0.287 P50747 D634Y Disease 0.777 0.621 0.02 32 0.803 P50747 D715G Disease 0.764 0.976 0.04 63 0.937 P50747 G518E Disease 0.696 0.961 0.00 63 0.934 P50747 G581S Disease 0.392 0.665 0.60 30 0.497 P50747 G582R Disease 0.976 0.966 0.03 70 0.956 P50747 L216R Disease NA 0.882 0.02 61 0.886 P50747 L237P Disease NA 0.586 0.02 45 0.731 P50747 L470S Disease 0.633 0.618 0.01 32 0.754 P50747 N511K Disease 0.469 0.956 0.30 40 0.819 P50747 R183P Disease NA 0.571 0.05 53 0.732 P50747 R360S Disease NA 0.744 0.00 64 0.888 P50747 R508W Disease 0.981 0.965 0.00 61 0.959 P50747 T462I Disease 0.716 0.748 0.10 31 0.702 P50747 V333E Disease NA 0.396 0.04 63 0.665 P50747 V363D Disease NA 0.467 0.01 45 0.584 P50747 V547G Disease 0.506 0.415 0.01 29 0.579 P50747 V550M Disease 0.738 0.519 0.09 -1 0.740 P50747 Y456C Disease 0.647 0.865 0.02 40 0.858 P50748 K245N Polymorphism 0.477 0.060 NA 41 0.083 P50748 V2021G Polymorphism 0.458 0.611 NA 22 0.709 P50750 F59L Polymorphism 0.834 0.513 0.45 21 0.688 P50750 G231A Polymorphism 0.234 0.755 0.04 16 0.457 P50851 A2704T Polymorphism 0.602 0.123 0.10 -39 0.369 P50851 G1230D Polymorphism NA 0.148 NA 21 0.017 P50851 L2713F Polymorphism 0.837 0.114 0.03 19 0.414 P50851 N1677S Polymorphism NA 0.250 0.00 24 0.412 P50851 R1997C Polymorphism NA 0.848 0.00 34 0.847 P50851 S2809L Polymorphism 0.491 0.124 0.66 -9 0.165 P50876 T4A Polymorphism NA 0.102 1.00 -24 0.049 P50895 R77H Polymorphism 0.655 0.160 0.58 54 0.330 P50895 K451Q Polymorphism 0.383 0.201 0.26 11 0.223 P50895 M204K Polymorphism 0.438 0.390 0.50 65 0.360 P50895 Q581L Polymorphism 0.110 0.128 0.22 11 0.163 P50895 T539A Polymorphism 0.065 0.235 0.52 9 0.145 P50895 V196I Polymorphism 0.092 0.129 0.19 23 0.155 P50897 D79G Disease 0.232 0.894 0.21 43 0.509 P50897 G42E Disease 0.790 0.891 0.06 63 0.925 P50897 H39Q Disease 0.920 0.938 0.00 64 0.950 P50897 T75P Disease NA 0.445 0.29 -34 0.403 P50897 W38C Disease 0.941 0.901 0.02 52 0.937 P50897 G108R Disease 0.948 0.909 0.00 48 0.909 P50897 G250V Disease 0.855 0.778 0.01 19 0.726 P50897 I134T Polymorphism 0.347 0.301 0.55 -38 0.350 P50897 L219Q Disease 0.940 0.822 0.01 33 0.866 P50897 Q177E Disease 0.858 0.873 0.02 64 0.938 P50897 R122W Disease 0.995 0.899 0.00 61 0.954 P50897 V181L Disease 0.715 0.643 0.10 34 0.706 P50897 V181M Disease 0.875 0.651 0.02 43 0.830 P50897 Y109D Disease 0.968 0.769 0.03 43 0.881 P50897 Y247H Disease 0.901 0.868 0.00 67 0.938 P50914 A138S Polymorphism 0.237 0.070 0.40 -21 0.062 P50990 H4Q Polymorphism 0.106 0.189 0.15 7 0.186 P50990 V409I Polymorphism 0.189 0.375 0.34 8 0.278 P50993 L764P Disease 0.875 0.881 0.04 30 0.808 P50993 M731T Disease 0.995 0.925 0.00 59 0.940 P50993 R689Q Disease 0.673 0.929 0.00 71 0.938 P50993 T378N Disease 0.999 0.831 0.00 59 0.944 P50993 W887R Disease NA 0.837 0.04 51 0.876 P50995 R191Q Polymorphism 0.440 0.562 0.87 23 0.437 P51114 A614V Polymorphism 0.113 0.034 0.16 14 0.035 P51114 D429N Polymorphism 0.152 0.155 0.01 24 0.213 P51116 R591P Polymorphism 0.548 0.357 0.05 31 0.508 P51149 K32E Polymorphism 0.239 0.551 0.31 9 0.305 P51149 K157N Disease NA 0.892 0.03 52 0.881 P51149 L129F Disease NA 0.893 0.13 48 0.871 P51149 N161T Disease NA 0.838 0.00 49 0.873 P51149 V162M Disease NA 0.881 0.00 55 0.891 P51159 L84F Polymorphism 0.454 0.704 0.00 44 0.797 P51159 T62S Polymorphism NA 0.585 0.75 -10 0.422 P51159 T85P Polymorphism 0.817 0.925 0.00 67 0.773 P51159 W73G Disease 0.955 0.875 0.00 75 0.812 P51159 A152P Disease NA 0.911 0.00 56 0.857 P51159 L130P Disease 0.759 0.879 0.00 45 0.795 P51160 D157E Polymorphism NA 0.742 0.01 48 0.679 P51160 E834G Polymorphism 0.300 0.319 0.34 30 0.391 P51160 K822N Polymorphism 0.500 0.300 0.20 47 0.439 P51161 R33H Polymorphism 0.676 0.283 0.11 34 0.446 P51161 T79M Polymorphism 0.419 0.273 0.01 25 0.348 P51168 G37S Disease NA 0.663 0.00 40 0.739 P51168 E632G Polymorphism NA 0.190 0.05 22 0.174 P51168 G589S Polymorphism NA 0.150 0.20 31 0.123 P51168 P616L Disease 0.742 0.248 0.01 31 0.605 P51168 P616S Disease 0.627 0.255 0.08 36 0.576 P51168 P617S Disease 0.627 0.212 0.06 30 0.427 P51168 P618R Disease 0.740 0.201 0.01 37 0.454 P51168 R624C Polymorphism 0.856 0.308 0.04 37 0.600 P51168 V434M Polymorphism 0.577 0.193 0.10 34 0.396 P51168 Y620H Disease 0.622 0.262 0.01 46 0.609 P51170 A502P Polymorphism 0.169 0.434 0.03 39 0.540 P51170 A614S Polymorphism NA 0.080 0.73 -21 0.070 P51170 G183S Polymorphism NA 0.062 1.00 -14 0.039 P51170 R178W Polymorphism NA 0.354 0.02 47 0.593 P51172 C532Y Polymorphism 0.083 0.437 0.44 25 0.375 P51172 E380Q Polymorphism 0.367 0.410 0.90 -26 0.266 P51172 G562S Polymorphism 0.332 0.179 0.67 0 0.203 P51172 R180P Polymorphism NA 0.460 0.11 17 0.520 P51451 T48I Polymorphism NA 0.154 0.16 13 0.200 P51460 P49S Polymorphism 0.607 0.424 0.00 8 0.495 P51460 P93L Disease 0.101 0.117 0.45 8 0.042 P51460 V43L Polymorphism 0.424 0.435 0.00 27 0.447 P51460 N110K Disease 0.373 0.360 0.00 34 0.278 P51460 R102C Disease 0.577 0.137 0.01 56 0.220 P51460 R102H Polymorphism 0.113 0.082 0.35 5 0.031 P51504 D253A Polymorphism 0.898 0.313 1.00 -27 0.029 P51508 A213E Polymorphism 0.425 0.556 0.15 -30 0.197 P51508 G117V Polymorphism 0.655 0.406 0.31 2 0.609 P51508 N157S Polymorphism 0.296 0.320 0.81 -18 0.186 P51508 S179N Disease 0.462 0.430 0.63 -5 0.288 P51508 S185L Polymorphism 0.504 0.139 0.63 8 0.273 P51511 D596G Polymorphism NA 0.269 0.16 -8 0.238 P51511 L200P Polymorphism 0.635 0.872 0.21 4 0.822 P51511 R622W Polymorphism NA 0.190 0.03 45 0.329 P51522 T70I Polymorphism 0.291 0.108 0.28 0 0.276 P51522 H392R Polymorphism 0.494 0.354 0.13 0 0.198 P51522 T119M Polymorphism 0.664 0.195 0.00 35 0.322 P51532 M1036I Polymorphism 0.424 0.571 0.41 3 0.383 P51570 G36R Disease NA 0.928 0.00 67 0.928 P51570 H44Y Disease NA 0.891 0.04 65 0.758 P51570 P28T Disease NA 0.456 0.35 -32 0.307 P51570 R68C Disease NA 0.759 0.00 48 0.842 P51570 V32M Disease NA 0.440 0.01 36 0.548 P51570 A198V Disease 0.321 0.757 0.00 -6 0.521 P51570 A384P Disease NA 0.841 0.06 22 0.831 P51570 G274D Polymorphism 0.132 0.531 0.63 39 0.165 P51570 G346S Disease 0.399 0.866 0.03 51 0.888 P51570 G349S Disease 0.443 0.914 0.04 69 0.916 P51570 R239Q Disease 0.628 0.911 0.00 74 0.923 P51570 T288M Disease 0.477 0.594 0.01 43 0.793 P51570 V338A Polymorphism 0.329 0.597 0.04 0 0.461 P51575 M396V Polymorphism 0.119 0.051 0.23 13 0.062 P51580 A80P Disease 0.740 0.939 0.03 56 0.925 P51580 L49S Polymorphism 0.790 0.877 0.00 45 0.889 P51580 A154T Disease 0.502 0.933 0.00 52 0.894 P51580 H227Q Disease 0.304 0.100 0.30 7 0.144 P51580 Q179H Polymorphism 0.092 0.240 0.21 12 0.197 P51580 R215H Disease 0.074 0.075 0.20 -14 0.064 P51580 Y240C Disease 0.646 0.795 0.00 35 0.834 P51582 S234A Polymorphism 0.076 0.164 0.86 24 0.100 P51587 F32L Disease NA 0.300 0.00 37 0.446 P51587 F81L Disease NA 0.391 0.00 38 0.578 P51587 G25R Disease NA 0.385 0.00 55 0.647 P51587 K53R Disease NA 0.075 0.00 32 0.133 P51587 N60S Disease NA 0.056 0.54 25 0.045 P51587 T64I Disease NA 0.290 0.00 41 0.405 P51587 W31C Disease NA 0.621 0.00 57 0.719 P51587 W31R Disease NA 0.602 0.00 61 0.818 P51587 Y42C Disease NA 0.220 0.00 26 0.189 P51587 C554W Disease NA 0.462 0.00 59 0.438 P51587 D707Y Polymorphism 0.534 0.223 0.00 49 0.507 P51587 D728A Disease 0.194 0.069 0.09 29 0.114 P51587 D935N Disease NA 0.225 0.00 21 0.302 P51587 E462G Disease NA 0.073 0.00 34 0.126 P51587 G405R Disease NA 0.218 0.32 47 0.281 P51587 H372N Polymorphism NA 0.016 1.00 -13 0.020 P51587 I505T Disease NA 0.236 0.00 9 0.174 P51587 I729M Disease 0.228 0.055 0.19 18 0.107 P51587 I982L Polymorphism 0.140 0.057 NA -2 0.072 P51587 K322Q Polymorphism NA 0.265 0.00 51 0.299 P51587 K327E Disease NA 0.204 0.00 38 0.117 P51587 K513R Polymorphism NA 0.052 0.26 -16 0.031 P51587 L613R Disease NA 0.181 0.00 44 0.196 P51587 L929S Polymorphism 0.645 0.098 0.03 11 0.234 P51587 M784V Polymorphism 0.114 0.015 0.93 -19 0.051 P51587 N108H Polymorphism NA 0.035 0.20 13 0.049 P51587 N289H Polymorphism NA 0.204 0.00 54 0.193 P51587 N886I Polymorphism 0.674 0.065 0.16 21 0.164 P51587 N987I Polymorphism 0.462 0.043 0.03 33 0.130 P51587 N991D Polymorphism 0.072 0.016 1.00 -33 0.036 P51587 P201R Disease NA 0.311 0.00 50 0.517 P51587 P222S Disease NA 0.123 0.00 30 0.168 P51587 R448H Disease NA 0.017 0.71 -21 0.017 P51587 S326R Disease NA 0.085 0.09 32 0.069 P51587 S599F Polymorphism NA 0.221 0.00 42 0.223 P51587 S976F Polymorphism 0.226 0.052 0.00 28 0.164 P51587 T431I Disease NA 0.145 0.47 18 0.123 P51587 T582P Polymorphism NA 0.267 0.00 37 0.190 P51587 T598A Polymorphism NA 0.060 1.00 -11 0.028 P51587 V211A Disease NA 0.042 0.99 -24 0.034 P51587 A2466V Polymorphism 0.233 0.091 NA 20 0.078 P51587 A2951T Polymorphism NA 0.165 0.00 30 0.252 P51587 C1290Y Polymorphism 0.136 0.273 0.00 26 0.265 P51587 C1580Y Disease 0.491 0.227 1.00 21 0.282 P51587 D1420Y Polymorphism 0.857 0.210 0.02 39 0.372 P51587 D1513N Polymorphism 0.341 0.029 0.09 -15 0.042 P51587 D1902N Polymorphism 0.284 0.169 0.00 15 0.205 P51587 D2238E Polymorphism 0.164 0.050 0.00 0 0.094 P51587 D2723H Disease 0.852 0.837 0.00 72 0.936 P51587 E1036K Disease 0.162 0.166 0.00 22 0.251 P51587 E1593D Polymorphism 0.158 0.113 0.00 18 0.172 P51587 E1901K Disease 0.394 0.212 0.50 16 0.234 P51587 E2089D Disease 0.460 0.232 0.00 13 0.237 P51587 E2275G Disease 0.385 0.068 0.39 5 0.056 P51587 E2856A Polymorphism 0.595 0.060 0.00 14 0.172 P51587 F1524V Disease 0.333 0.452 0.00 50 0.565 P51587 F2293L Disease 0.196 0.376 0.00 40 0.569 P51587 G1771D Disease 0.207 0.153 1.00 28 0.137 P51587 G2274V Disease 0.444 0.407 0.00 32 0.482 P51587 G2353R Disease 0.178 0.078 0.06 26 0.071 P51587 G2793R Disease 0.831 0.894 0.00 67 0.939 P51587 G3076E Polymorphism 0.333 0.774 0.00 58 0.871 P51587 H1561N Polymorphism 0.251 0.268 0.00 24 0.317 P51587 H2074N Polymorphism 0.173 0.125 0.00 11 0.150 P51587 H2415N Disease 0.506 0.124 0.31 21 0.086 P51587 H2440R Polymorphism 0.172 0.057 0.60 11 0.048 P51587 I1929V Disease 0.307 0.088 0.00 -2 0.186 P51587 I2490T Polymorphism 0.237 0.076 0.04 19 0.084 P51587 I2944F Polymorphism 0.712 0.075 0.00 35 0.272 P51587 I3412V Polymorphism NA 0.057 NA 4 0.060 P51587 K1445T Disease 0.134 0.201 0.00 43 0.293 P51587 K1690N Disease 0.644 0.163 0.06 26 0.367 P51587 K2128N Disease 0.333 0.136 0.39 17 0.075 P51587 K2162R Polymorphism 0.383 0.041 0.33 13 0.047 P51587 K2729N Disease 0.687 0.213 0.06 45 0.229 P51587 K2950N Disease NA 0.078 0.00 4 0.134 P51587 K3196E Disease 0.501 0.209 0.00 29 0.338 P51587 K3257R Polymorphism 0.175 0.013 0.52 -38 0.040 P51587 L2480V Polymorphism 0.326 0.036 0.00 26 0.102 P51587 L2510P Disease 0.935 0.623 0.00 37 0.807 P51587 L2686P Polymorphism 0.890 0.819 0.00 34 0.886 P51587 L2792P Polymorphism 0.794 0.906 0.00 58 0.935 P51587 L3101R Polymorphism 0.521 0.782 0.00 46 0.855 P51587 M3118T Disease 0.137 0.064 0.11 -13 0.067 P51587 N1147S Polymorphism 0.241 0.056 0.00 26 0.171 P51587 N1279S Polymorphism 0.415 0.195 0.00 1 0.266 P51587 N1730Y Disease 0.515 0.081 0.03 32 0.187 P51587 N1805S Polymorphism 0.241 0.136 0.00 0 0.179 P51587 N1880K Polymorphism 0.399 0.035 0.22 1 0.110 P51587 N2135H Disease 0.557 0.112 0.00 31 0.219 P51587 N2447D Polymorphism 0.168 0.052 NA -17 0.062 P51587 N2706S Polymorphism NA 0.117 0.78 -8 0.074 P51587 N3124I Disease 0.876 0.329 0.00 39 0.614 P51587 P2096L Disease 0.198 0.184 0.00 20 0.251 P51587 Q2421H Disease 0.504 0.051 1.00 -11 0.036 P51587 Q2456E Disease 0.315 0.141 0.00 10 0.129 P51587 R2034C Polymorphism 0.742 0.107 0.05 31 0.287 P51587 R2108C Polymorphism 0.883 0.054 0.02 24 0.073 P51587 R2336H Disease 0.332 0.078 0.38 7 0.046 P51587 R2336Q Polymorphism 0.185 0.059 0.54 12 0.044 P51587 R2488K Disease 0.451 0.198 0.00 13 0.227 P51587 R3276S Polymorphism 0.511 0.157 0.00 34 0.235 P51587 S1106R Disease 0.560 0.299 0.00 44 0.612 P51587 S1172L Disease 0.552 0.245 0.00 36 0.555 P51587 S1179N Disease 0.506 0.073 0.57 2 0.118 P51587 S1979R Polymorphism 0.377 0.313 0.00 38 0.420 P51587 S2072C Disease 0.797 0.095 0.03 28 0.333 P51587 S2835P Polymorphism 0.258 0.469 0.25 -11 0.278 P51587 T1414M Polymorphism 0.337 0.013 0.60 -22 0.048 P51587 T1679I Disease 0.152 0.065 0.00 -7 0.098 P51587 T1887M Disease 0.471 0.106 0.00 31 0.170 P51587 T1915M Polymorphism 0.399 0.021 0.06 -18 0.045 P51587 T2031A Disease 0.289 0.046 0.13 -27 0.117 P51587 T2515I Disease 0.637 0.161 0.04 45 0.128 P51587 T2722R Disease 0.739 0.931 0.00 62 0.944 P51587 T3013I Disease 0.238 0.237 0.37 34 0.318 P51587 T3357R Disease 0.314 0.115 0.06 19 0.114 P51587 T3374I Polymorphism NA 0.149 0.12 22 0.127 P51587 V1542M Polymorphism 0.521 0.075 0.00 36 0.274 P51587 V1643A Polymorphism 0.288 0.047 0.04 11 0.115 P51587 V1804A Disease 0.374 0.159 0.04 35 0.282 P51587 V2118L Disease 0.294 0.080 0.00 18 0.150 P51587 V2138F Polymorphism 0.410 0.147 NA 20 0.132 P51587 V2728I Disease 0.151 0.048 0.00 -23 0.168 P51587 V2969M Polymorphism 0.690 0.248 0.00 -5 0.439 P51587 V3244I Polymorphism 0.335 0.038 0.65 13 0.054 P51587 W2626C Disease 0.868 0.941 0.00 62 0.949 P51587 Y2094C Disease 0.600 0.221 0.04 -16 0.266 P51587 Y2222C Disease 0.752 0.352 0.00 30 0.341 P51587 Y3098H Disease 0.235 0.075 0.17 -2 0.068 P51589 R49S Polymorphism 0.149 0.376 0.02 -4 0.151 P51589 I192N Polymorphism 0.934 0.888 0.00 47 0.897 P51589 N124S Polymorphism 0.267 0.318 0.40 9 0.322 P51589 N404Y Polymorphism 0.813 0.607 0.03 34 0.754 P51589 T143A Polymorphism 0.246 0.165 0.22 -24 0.196 P51589 V113M Polymorphism 0.340 0.205 0.12 -49 0.332 P51608 D97E Disease 0.396 0.339 0.12 14 0.274 P51608 D97Y Disease 0.829 0.572 0.04 38 0.734 P51608 E10Q Disease 0.176 0.144 0.09 5 0.167 P51608 A140V Disease 0.517 0.229 0.24 5 0.369 P51608 A181V Polymorphism 0.321 0.077 0.19 -42 0.030 P51608 A201V Polymorphism 0.341 0.057 0.24 -25 0.027 P51608 A287P Polymorphism 0.438 0.329 0.07 31 0.225 P51608 A439T Polymorphism 0.114 0.106 0.97 20 0.054 P51608 D156G Disease 0.588 0.694 0.05 20 0.818 P51608 E137G Disease 0.575 0.215 0.03 39 0.433 P51608 F155I Disease 0.541 0.607 0.06 30 0.748 P51608 F155S Disease 0.690 0.783 0.01 18 0.838 P51608 G161V Disease 0.763 0.447 0.19 27 0.440 P51608 G232A Polymorphism 0.405 0.141 0.16 -7 0.105 P51608 G428S Disease 0.510 0.097 0.00 -26 0.153 P51608 K135E Disease 0.488 0.622 0.40 36 0.711 P51608 K210I Disease 0.603 0.272 0.01 -6 0.457 P51608 K284E Disease 0.145 0.377 0.02 14 0.165 P51608 K305R Disease 0.279 0.247 0.06 -15 0.185 P51608 L100R Disease 0.749 0.630 0.00 50 0.839 P51608 L100V Disease 0.394 0.089 0.13 32 0.125 P51608 L124F Disease 0.518 0.102 0.89 -3 0.102 P51608 P101H Disease 0.861 0.491 0.01 35 0.755 P51608 P101L Disease 0.749 0.590 0.01 23 0.757 P51608 P101R Disease 0.764 0.390 0.03 36 0.627 P51608 P101S Disease 0.635 0.360 0.04 26 0.593 P51608 P101T Disease 0.695 0.500 0.02 29 0.754 P51608 P152R Disease 0.764 0.360 0.46 37 0.497 P51608 P225L Disease 0.497 0.191 0.03 20 0.178 P51608 P225R Disease 0.528 0.169 0.05 12 0.189 P51608 P302A Disease 0.335 0.095 0.07 12 0.074 P51608 P302H Disease 0.735 0.179 0.02 28 0.292 P51608 P302L Disease 0.613 0.283 0.03 16 0.310 P51608 P302R Disease 0.600 0.147 0.23 29 0.210 P51608 P322A Disease 0.203 0.062 0.00 -14 0.105 P51608 P322L Disease 0.424 0.163 0.00 7 0.183 P51608 P322S Disease 0.227 0.135 0.00 9 0.162 P51608 P376S Polymorphism 0.091 0.114 0.16 12 0.090 P51608 P399L Disease 0.196 0.054 0.02 -1 0.072 P51608 P402L Polymorphism 0.140 0.062 0.00 -3 0.094 P51608 P480S Polymorphism 0.126 0.141 0.00 2 0.159 P51608 Q128P Disease 0.412 0.793 0.14 10 0.704 P51608 R106Q Disease 0.557 0.471 0.18 41 0.655 P51608 R106W Disease 0.903 0.555 0.01 41 0.792 P51608 R111G Disease 0.658 0.572 0.02 63 0.911 P51608 R133C Disease 0.869 0.819 0.00 63 0.939 P51608 R133H Disease 0.716 0.748 0.02 59 0.896 P51608 R167W Disease 0.903 0.229 0.01 -5 0.513 P51608 R306C Disease 0.773 0.400 0.00 38 0.378 P51608 R306H Disease 0.581 0.310 0.02 23 0.335 P51608 R344W Disease 0.652 0.110 0.01 24 0.274 P51608 R453Q Disease 0.285 0.282 0.00 0 0.198 P51608 S134C Disease 0.734 0.652 0.03 51 0.849 P51608 S359P Polymorphism 0.330 0.057 0.06 18 0.051 P51608 T158A Disease 0.362 0.339 0.17 12 0.520 P51608 T158M Disease 0.749 0.415 0.03 21 0.578 P51608 T228S Polymorphism 0.103 0.084 0.59 4 0.045 P51608 Y120D Disease 0.780 0.589 0.20 47 0.761 P51610 S1164P Polymorphism NA 0.143 0.80 -41 0.013 P51610 S2004I Polymorphism NA 0.235 0.00 16 0.388 P51617 C203S Polymorphism 0.251 0.146 0.40 -32 0.125 P51617 G619S Polymorphism 0.040 0.067 0.46 -27 0.074 P51617 R194H Polymorphism 0.057 0.266 0.14 -23 0.233 P51617 R638W Polymorphism NA 0.167 0.03 36 0.200 P51617 S532L Polymorphism NA 0.269 1.00 4 0.265 P51648 I45F Disease 0.612 0.528 0.23 17 0.624 P51648 V64D Disease 0.862 0.788 0.31 56 0.921 P51648 C214Y Disease 0.715 0.731 0.39 40 0.824 P51648 C226W Disease 0.820 0.652 0.00 27 0.809 P51648 C237Y Disease 0.901 0.727 0.03 60 0.911 P51648 D245N Disease 0.682 0.604 0.16 46 0.569 P51648 F419S Disease 0.811 0.809 0.00 53 0.909 P51648 G185A Disease 0.998 0.803 0.00 67 0.928 P51648 G406R Disease 0.980 0.873 0.00 77 0.933 P51648 G412R Disease 0.980 0.822 0.01 76 0.930 P51648 H411Y Disease 0.925 0.894 0.38 64 0.908 P51648 K266N Disease 0.306 0.296 0.18 -6 0.308 P51648 K447E Disease 0.378 0.881 0.80 55 0.839 P51648 L106R Disease 0.960 0.843 0.08 52 0.915 P51648 M328I Disease 0.905 0.726 0.12 52 0.799 P51648 N386S Disease 0.858 0.960 0.00 73 0.932 P51648 P114L Disease 0.979 0.908 0.00 55 0.936 P51648 P121L Disease 0.810 0.930 0.06 39 0.855 P51648 P315S Disease 0.967 0.800 0.01 58 0.925 P51648 R228C Disease 0.979 0.573 0.04 51 0.909 P51648 R423H Disease 0.854 0.597 0.01 48 0.856 P51648 S365L Disease 0.902 0.729 0.01 45 0.867 P51648 S415N Disease 0.878 0.744 0.10 46 0.871 P51648 T184M Disease 0.981 0.923 0.00 69 0.923 P51648 T184R Disease 0.965 0.944 0.00 79 0.899 P51648 Y279N Disease 0.864 0.632 0.10 45 0.831 P51649 C93F Disease NA 0.783 0.04 -2 0.475 P51649 C223Y Disease 0.951 0.951 0.14 60 0.924 P51649 G176R Disease 0.946 0.881 0.00 61 0.925 P51649 G268E Disease 0.769 0.920 0.00 54 0.929 P51649 G409D Disease 0.625 0.932 0.00 70 0.939 P51649 G533R Disease 0.024 0.948 0.15 53 0.843 P51649 H180Y Polymorphism 0.149 0.579 0.40 18 0.264 P51649 N255S Disease 0.588 0.905 0.00 14 0.601 P51649 N335K Disease 0.541 0.933 0.01 47 0.903 P51649 P182L Polymorphism 0.295 0.570 0.17 -1 0.398 P51649 P382L Disease 0.824 0.888 0.00 42 0.897 P51649 P382Q Disease 0.888 0.821 0.00 45 0.900 P51649 T233M Disease 0.884 0.884 0.00 57 0.921 P51649 V487E Disease 0.621 0.798 0.03 37 0.875 P51654 W296R Disease 0.990 0.923 0.00 61 0.963 P51659 F90L Polymorphism 0.190 0.672 0.08 41 0.432 P51659 G16S Disease 0.750 0.908 0.01 71 0.930 P51659 A606S Polymorphism NA 0.222 0.48 -38 0.236 P51659 K140N Polymorphism 0.239 0.785 0.01 -18 0.545 P51659 R106H Polymorphism 0.336 0.650 0.08 57 0.723 P51659 W511R Polymorphism NA 0.307 0.56 -5 0.179 P51671 K86T Polymorphism 0.320 0.167 0.47 11 0.260 P51677 G21D Polymorphism 0.124 0.459 0.35 19 0.237 P51677 C218S Polymorphism 0.684 0.706 0.09 33 0.675 P51679 C178S Polymorphism 0.436 0.140 0.48 -11 0.122 P51681 A29S Polymorphism 0.248 0.175 0.46 -25 0.142 P51681 A73V Polymorphism 0.937 0.578 0.00 0 0.844 P51681 C20S Polymorphism 0.816 0.945 0.05 52 0.807 P51681 L55Q Polymorphism 0.968 0.756 0.00 18 0.835 P51681 R60S Polymorphism 0.291 0.373 0.12 32 0.386 P51681 G301V Polymorphism 0.960 0.897 0.00 42 0.935 P51685 A27G Polymorphism 0.138 0.290 0.05 4 0.160 P51686 I92V Polymorphism 0.068 0.055 0.85 -48 0.048 P51687 A265D Disease 0.765 0.778 0.00 50 0.795 P51687 G362S Disease 0.796 0.865 0.00 57 0.929 P51687 G530D Disease 0.489 0.894 0.00 76 0.929 P51687 I258L Disease 0.223 0.610 0.73 -35 0.269 P51687 K379R Disease 0.718 0.870 0.00 52 0.902 P51687 Q396R Disease 0.556 0.351 0.04 28 0.628 P51687 R217Q Disease 0.586 0.738 0.00 71 0.880 P51687 R268Q Disease 0.513 0.777 0.00 59 0.854 P51687 R366H Disease 0.934 0.865 0.00 63 0.937 P51687 S427Y Disease 0.928 0.845 0.00 63 0.927 P51687 W450R Disease 0.803 0.893 0.00 68 0.929 P51688 A44T Disease 0.467 0.396 0.61 -6 0.198 P51688 D32E Disease 0.878 0.916 0.00 31 0.895 P51688 D32G Disease 0.932 0.946 0.00 30 0.899 P51688 G90R Disease 0.437 0.903 0.15 48 0.815 P51688 H84Y Disease 0.607 0.853 0.12 66 0.769 P51688 M88T Disease 0.189 0.704 0.02 40 0.387 P51688 N42K Disease 0.280 0.710 0.27 41 0.551 P51688 Q85R Disease 0.170 0.467 0.99 24 0.239 P51688 R74C Disease 0.985 0.885 0.00 73 0.956 P51688 R74H Disease 0.967 0.856 0.00 73 0.951 P51688 S66W Disease 0.937 0.694 0.00 54 0.912 P51688 T79P Disease 0.881 0.962 0.01 59 0.941 P51688 Y40N Disease 0.948 0.905 0.40 55 0.928 P51688 A234G Disease 0.494 0.730 0.17 3 0.472 P51688 A354P Disease 0.482 0.913 0.02 11 0.618 P51688 D179N Disease 0.296 0.821 0.84 55 0.562 P51688 D235N Disease 0.640 0.860 0.49 23 0.737 P51688 D235V Disease 0.814 0.811 0.28 43 0.846 P51688 D273N Disease 0.764 0.959 0.00 76 0.943 P51688 E300V Disease 0.524 0.723 0.21 29 0.609 P51688 E355K Disease 0.196 0.901 0.94 5 0.404 P51688 E369K Disease NA 0.779 0.57 61 0.703 P51688 E447K Disease 0.867 0.971 0.00 68 0.942 P51688 F193L Disease NA 0.729 1.00 39 0.530 P51688 G122R Disease 0.886 0.936 0.00 75 0.940 P51688 G191R Disease NA 0.938 0.56 33 0.617 P51688 G251A Disease 0.427 0.890 0.00 29 0.669 P51688 I322S Disease 0.426 0.716 0.09 3 0.532 P51688 L146P Disease 0.422 0.888 0.15 14 0.582 P51688 L163P Disease 0.799 0.936 0.01 41 0.863 P51688 L386R Disease 0.914 0.784 0.12 66 0.911 P51688 N389K Disease 0.763 0.869 1.00 55 0.803 P51688 P128L Disease 0.473 0.696 1.00 35 0.609 P51688 P227R Disease 0.650 0.878 0.32 52 0.796 P51688 P288S Disease 0.246 0.326 0.14 6 0.276 P51688 P293S Disease 0.729 0.907 0.00 46 0.779 P51688 P293T Disease 0.789 0.933 0.00 61 0.939 P51688 Q307P Disease 0.519 0.904 0.26 18 0.851 P51688 Q380R Disease 0.345 0.320 1.00 22 0.192 P51688 R150Q Disease 0.317 0.541 0.63 59 0.578 P51688 R150W Disease 0.891 0.771 0.02 59 0.870 P51688 R182C Disease 0.811 0.937 0.18 55 0.931 P51688 R206P Disease NA 0.934 0.15 28 0.621 P51688 R245H Disease 0.665 0.402 0.10 52 0.637 P51688 R377C Disease 0.984 0.967 0.09 63 0.954 P51688 R377H Disease 0.966 0.942 0.29 58 0.953 P51688 R433Q Disease 0.770 0.921 0.36 60 0.792 P51688 R433W Disease 0.975 0.955 0.03 59 0.991 P51688 S106R Disease 0.565 0.774 0.13 47 0.855 P51688 S298P Disease 0.634 0.860 0.04 35 0.641 P51688 S364R Disease 0.445 0.555 0.58 67 0.639 P51688 T139M Disease 0.549 0.486 0.04 26 0.662 P51688 T321A Disease 0.690 0.944 0.00 51 0.908 P51688 V131M Disease 0.370 0.490 0.22 10 0.422 P51688 V387M Polymorphism 0.630 0.520 0.01 31 0.631 P51688 V486F Disease 0.529 0.368 0.75 54 0.575 P51688 Y374H Disease 0.885 0.713 0.01 58 0.888 P51689 V500I Polymorphism NA 0.028 0.96 0 0.047 P51690 I80N Disease 0.709 0.822 0.02 9 0.852 P51690 R12S Disease NA 0.575 0.00 -9 0.484 P51690 C492Y Disease NA 0.730 0.01 41 0.717 P51690 G117R Disease 0.316 0.774 0.11 40 0.596 P51690 G137V Disease 0.970 0.903 0.00 61 0.933 P51690 G245R Disease NA 0.921 0.33 12 0.568 P51690 G424S Polymorphism 0.317 0.290 0.52 15 0.341 P51690 P578S Disease 0.330 0.693 0.60 35 0.570 P51690 R111P Disease NA 0.686 0.26 18 0.516 P51690 R183H Polymorphism 0.268 0.281 0.31 -4 0.210 P51690 T481M Disease 0.739 0.341 0.05 50 0.669 P51692 A630P Disease 0.826 0.804 0.03 22 0.880 P51787 A178P Disease 0.396 0.862 0.01 60 0.888 P51787 A178T Disease 0.222 0.516 0.01 28 0.504 P51787 A194P Disease 0.396 0.764 0.10 61 0.799 P51787 A300T Disease 0.880 0.766 0.07 38 0.871 P51787 A341E Disease 0.955 0.938 0.00 47 0.921 P51787 A341V Disease 0.920 0.919 0.00 30 0.899 P51787 A344V Disease 0.920 0.774 0.81 -1 0.730 P51787 A371T Disease 0.883 0.899 0.09 40 0.885 P51787 A525T Disease 0.340 0.710 0.11 32 0.625 P51787 D242N Disease 0.920 0.601 0.09 34 0.786 P51787 D317N Disease 0.920 0.793 0.00 59 0.929 P51787 E160K Disease 0.932 0.939 0.00 66 0.941 P51787 E261D Disease 0.868 0.797 0.00 51 0.850 P51787 E261K Disease 0.934 0.932 0.00 62 0.940 P51787 F157C Disease 0.619 0.932 0.06 37 0.867 P51787 G168R Disease 0.483 0.837 0.01 48 0.871 P51787 G179S Disease 0.945 0.745 0.23 42 0.878 P51787 G189R Disease 0.976 0.887 0.01 50 0.947 P51787 G216R Disease 0.483 0.802 0.05 30 0.571 P51787 G269D Disease 0.969 0.889 0.19 44 0.905 P51787 G269S Disease 0.947 0.796 0.35 2 0.806 P51787 G306R Disease 0.976 0.910 0.00 60 0.938 P51787 G314S Disease 0.947 0.834 0.00 56 0.934 P51787 G325R Disease 0.976 0.904 0.00 77 0.934 P51787 G345E Disease 0.970 0.943 0.11 47 0.926 P51787 G345R Disease 0.976 0.947 0.11 48 0.928 P51787 G589D Disease 0.548 0.436 0.13 25 0.567 P51787 G643S Polymorphism NA 0.053 1.00 -39 0.019 P51787 I313M Disease 0.287 0.445 0.00 61 0.679 P51787 K318N Disease 0.288 0.644 0.06 28 0.557 P51787 K393N Polymorphism 0.288 0.558 0.30 13 0.407 P51787 L250H Disease 0.981 0.809 0.00 10 0.829 P51787 L266P Disease 0.584 0.922 0.02 47 0.886 P51787 L273F Disease 0.885 0.902 0.01 8 0.869 P51787 L342F Disease 0.884 0.934 0.00 14 0.865 P51787 L353P Disease 0.972 0.872 0.02 47 0.894 P51787 P320A Disease 0.949 0.785 0.00 62 0.931 P51787 P448R Disease 0.296 0.327 0.05 4 0.306 P51787 R174C Disease 0.984 0.938 0.00 56 0.943 P51787 R174H Disease 0.964 0.904 0.00 46 0.926 P51787 R190Q Disease 0.934 0.835 0.01 55 0.923 P51787 R243C Disease 0.984 0.933 0.00 55 0.942 P51787 R243H Disease 0.965 0.914 0.00 33 0.907 P51787 R366P Disease 0.968 0.934 0.00 52 0.938 P51787 R366Q Disease 0.938 0.848 0.10 23 0.838 P51787 R366W Disease 0.989 0.900 0.00 38 0.921 P51787 R533W Disease 0.825 0.742 0.03 49 0.908 P51787 R539W Disease 0.825 0.812 0.01 35 0.864 P51787 R555C Disease 0.983 0.967 0.00 52 0.958 P51787 R583C Disease 0.736 0.781 0.02 31 0.838 P51787 R591H Disease 0.557 0.856 0.01 55 0.882 P51787 R594Q Disease 0.385 0.448 0.04 20 0.372 P51787 S140G Disease 0.231 0.688 0.37 34 0.471 P51787 S225L Disease 0.949 0.810 0.01 17 0.788 P51787 S349W Disease 0.989 0.932 0.00 49 0.937 P51787 S373P Disease 0.372 0.892 0.20 27 0.660 P51787 S566F Disease 0.560 0.709 0.09 21 0.625 P51787 T309R Disease 0.955 0.914 0.00 70 0.921 P51787 T311I Disease 0.265 0.906 0.00 28 0.640 P51787 T312I Disease 0.953 0.900 0.00 54 0.934 P51787 T391I Disease 0.265 0.930 0.19 26 0.520 P51787 T587M Disease 0.584 0.448 0.00 14 0.517 P51787 V254M Disease 0.339 0.603 0.02 38 0.567 P51787 V307L Disease 0.140 0.762 0.42 30 0.228 P51787 V310I Disease 0.110 0.375 0.04 11 0.158 P51787 V417M Disease 0.339 0.277 0.24 -30 0.178 P51787 W248R Disease 0.977 0.854 0.00 67 0.934 P51787 W305S Disease 0.979 0.913 0.00 70 0.940 P51787 W392R Disease 0.461 0.911 0.22 40 0.839 P51787 Y111C Disease 0.647 0.963 0.00 62 0.930 P51787 Y184S Disease 0.956 0.791 0.13 46 0.900 P51787 Y281C Disease 0.982 0.955 0.00 45 0.929 P51787 Y315C Disease 0.982 0.850 0.00 67 0.938 P51787 Y315S Disease 0.957 0.816 0.00 60 0.935 P51795 G57V Disease 0.819 0.368 0.22 -15 0.589 P51795 E527D Disease 0.992 0.847 0.00 71 0.948 P51795 G506E Disease 0.766 0.938 0.00 57 0.932 P51795 G512R Disease 0.762 0.966 0.01 56 0.929 P51795 L200R Disease 0.881 0.890 0.02 55 0.928 P51795 M142I Polymorphism 0.315 0.295 1.00 -37 0.188 P51795 R280P Disease 0.807 0.901 0.02 48 0.794 P51795 S244L Disease 0.755 0.912 0.03 -12 0.843 P51795 S520P Disease 0.617 0.895 0.01 49 0.899 P51798 G215R Disease 0.998 0.914 0.00 63 0.927 P51798 G240R Disease 0.886 0.878 0.02 49 0.922 P51798 G677V Disease 0.998 0.821 0.00 17 0.896 P51798 I261F Disease 0.582 0.712 0.19 -24 0.509 P51798 L490F Disease 0.618 0.514 0.02 -5 0.536 P51798 L614P Disease 0.884 0.938 0.00 11 0.889 P51798 L766P Disease 0.874 0.902 0.00 2 0.795 P51798 M332V Disease 0.151 0.382 0.60 -3 0.223 P51798 P249R Disease 0.998 0.888 0.00 50 0.948 P51798 R286Q Disease 0.579 0.930 0.00 63 0.912 P51798 R526W Disease 0.989 0.831 0.00 32 0.922 P51798 R762Q Disease 0.939 0.606 0.00 21 0.823 P51798 R767Q Disease 0.939 0.818 0.03 42 0.862 P51798 R767W Disease 0.989 0.868 0.00 48 0.921 P51798 S744F Disease 0.517 0.245 0.03 12 0.557 P51800 R83G Polymorphism 0.140 0.569 0.52 19 0.218 P51800 Y315F Polymorphism 0.067 0.285 0.93 -7 0.155 P51801 R27L Polymorphism 0.191 0.441 0.20 9 0.431 P51801 S88R Polymorphism 0.158 0.800 0.06 23 0.419 P51801 A204T Disease 0.348 0.803 0.01 33 0.652 P51801 A214G Polymorphism 0.071 0.536 1.00 -52 0.041 P51801 A349D Disease 0.942 0.900 0.01 50 0.910 P51801 I419V Polymorphism 0.157 0.479 0.05 -22 0.264 P51801 N143H Polymorphism 0.726 0.637 0.00 41 0.829 P51801 P124L Disease 0.986 0.817 0.00 42 0.916 P51801 R395W Polymorphism 0.742 0.800 0.13 2 0.774 P51801 R438C Disease 0.990 0.950 0.00 18 0.939 P51801 V104I Polymorphism 0.129 0.147 0.84 -50 0.105 P51801 Y432H Disease 0.459 0.586 0.00 21 0.745 P51805 G384S Polymorphism 0.221 0.568 0.19 -28 0.297 P51805 G413S Polymorphism 0.250 0.670 0.73 2 0.305 P51810 R5C Disease NA 0.409 NA 42 0.574 P51810 D78N Disease NA 0.641 NA 49 0.692 P51810 D78V Disease NA 0.682 NA 46 0.736 P51810 G35D Disease NA 0.291 NA 44 0.433 P51810 G84D Disease NA 0.886 NA 49 0.850 P51810 G84R Disease NA 0.906 NA 48 0.817 P51810 L39R Disease NA 0.592 NA 51 0.717 P51810 A138V Disease NA 0.788 NA 17 0.731 P51810 A173D Disease NA 0.389 NA 53 0.639 P51810 C116R Disease NA 0.906 NA 66 0.923 P51810 C116S Disease NA 0.832 NA 48 0.806 P51810 E233K Disease NA 0.305 NA 28 0.443 P51810 E235K Disease NA 0.630 NA 47 0.729 P51810 E271G Disease NA 0.286 NA 42 0.396 P51810 G118E Disease NA 0.662 NA 38 0.709 P51810 G229V Disease NA 0.650 NA 40 0.717 P51810 I244V Disease NA 0.108 NA -2 0.095 P51810 I261N Disease NA 0.517 NA 31 0.707 P51810 Q124R Disease NA 0.687 NA 36 0.704 P51810 S152N Disease NA 0.300 NA -2 0.436 P51810 T232K Disease NA 0.708 NA 40 0.760 P51810 W133R Disease NA 0.970 NA 58 0.744 P51810 W292C Disease NA 0.927 NA 54 0.908 P51810 W292G Disease NA 0.914 NA 51 0.886 P51811 C294R Disease NA 0.964 0.01 68 0.931 P51811 E327K Disease NA 0.972 0.01 62 0.922 P51811 R222G Disease NA 0.965 0.00 59 0.917 P51812 G75V Disease 0.998 0.859 0.00 67 0.947 P51812 I38S Polymorphism NA 0.410 0.44 -25 0.199 P51812 V82F Disease 0.998 0.930 0.00 65 0.949 P51812 A225V Disease 0.438 0.708 0.03 43 0.802 P51812 D154Y Disease 0.864 0.662 0.00 38 0.848 P51812 G431D Disease 0.780 0.881 0.00 84 0.923 P51812 H127Q Disease 0.729 0.771 0.17 63 0.613 P51812 R114W Disease 0.923 0.838 0.01 31 0.860 P51812 R729Q Disease NA 0.722 0.03 57 0.705 P51812 S227A Disease 0.394 0.510 0.01 40 0.763 P51813 S284L Polymorphism NA 0.061 0.10 -4 0.146 P51814 D357E Polymorphism 0.323 0.513 0.92 -16 0.261 P51814 P153L Disease 0.452 0.289 0.77 6 0.360 P51825 P209A Polymorphism NA 0.111 0.17 -12 0.092 P51826 S358N Polymorphism 0.809 0.042 1.00 -30 0.081 P51841 S40C Polymorphism NA 0.113 0.18 -8 0.125 P51841 E794K Polymorphism 0.549 0.952 0.01 43 0.845 P51841 G434R Polymorphism NA 0.380 0.53 45 0.354 P51841 L284P Polymorphism NA 0.899 0.02 37 0.853 P51841 R230W Polymorphism NA 0.656 0.01 25 0.750 P51841 R305Q Polymorphism NA 0.660 0.12 -4 0.501 P51841 V677L Polymorphism 0.285 0.305 0.35 5 0.352 P51841 Y308C Polymorphism NA 0.891 0.02 28 0.759 P51843 A300P Disease 0.661 0.920 0.00 66 0.922 P51843 A300V Disease 0.514 0.487 0.03 47 0.510 P51843 E377K Disease 0.749 0.959 0.00 75 0.940 P51843 I439S Disease 0.831 0.855 0.00 42 0.877 P51843 K382N Disease 0.787 0.961 0.01 54 0.916 P51843 L278P Disease 0.916 0.977 0.00 39 0.909 P51843 L295P Disease 0.815 0.953 0.00 53 0.924 P51843 L297P Disease 0.916 0.986 0.00 58 0.944 P51843 L381H Disease 0.934 0.948 0.00 65 0.950 P51843 L466R Disease 0.865 0.832 0.00 56 0.904 P51843 N440I Disease 0.657 0.397 0.01 38 0.597 P51843 R267P Disease 0.749 0.840 0.01 41 0.841 P51843 R425G Disease 0.476 0.964 0.00 64 0.931 P51843 R425T Disease 0.211 0.959 0.01 63 0.872 P51843 V287G Disease 0.666 0.535 0.00 35 0.734 P51843 V385G Disease 0.680 0.889 0.00 48 0.873 P51843 W291C Disease 0.955 0.943 0.06 60 0.962 P51843 Y380D Disease 0.768 0.929 0.06 56 0.910 P51854 I152T Polymorphism 0.616 0.806 0.03 44 0.796 P51857 L106F Disease 0.832 0.810 0.00 29 0.818 P51857 P133R Disease 0.542 0.924 0.00 30 0.850 P51857 P198L Disease 0.526 0.822 0.20 22 0.505 P51857 R261C Disease 0.968 0.943 0.00 39 0.920 P51888 M157V Polymorphism 0.141 0.691 0.01 32 0.269 P51888 N334S Polymorphism 0.115 0.572 0.72 -39 0.215 P51948 D282A Polymorphism 0.468 0.228 0.51 1 0.351 P51956 H23L Polymorphism 0.849 0.686 0.14 19 0.795 P51956 D461N Polymorphism NA 0.044 0.16 40 0.102 P51956 E305D Polymorphism 0.610 0.070 0.61 -41 0.074 P51956 E477K Polymorphism NA 0.174 0.05 34 0.167 P51956 R259G Polymorphism NA 0.643 0.33 25 0.514 P51957 F567L Polymorphism 0.175 0.053 0.18 -35 0.015 P51957 P225A Polymorphism 0.788 0.369 0.22 -16 0.563 P51957 T357I Polymorphism 0.808 0.120 0.06 25 0.308 P51959 F179L Polymorphism 0.258 0.069 1.00 -17 0.022 P51959 N178H Polymorphism 0.466 0.071 0.44 41 0.110 P51993 Q230K Polymorphism 0.087 0.539 0.36 -24 0.015 P52179 V22L Polymorphism NA 0.154 0.88 -48 0.009 P52179 T215M Polymorphism NA 0.187 0.00 46 0.354 P52179 D1408N Polymorphism 0.303 0.215 0.35 35 0.298 P52209 A268S Polymorphism 0.155 0.543 0.87 -55 0.166 P52306 K314E Polymorphism 0.362 0.141 0.91 35 0.152 P52333 P12L Polymorphism NA 0.095 0.26 -1 0.066 P52333 R40H Polymorphism NA 0.091 0.48 0 0.150 P52333 C759R Disease 0.112 0.920 0.01 74 0.882 P52333 D169E Disease 0.536 0.418 0.44 38 0.550 P52333 E481G Disease 0.503 0.728 0.18 48 0.763 P52333 G589S Disease 0.908 0.897 0.00 68 0.935 P52333 I688F Polymorphism 0.702 0.755 0.05 63 0.794 P52333 L521V Polymorphism 0.157 0.407 0.26 21 0.270 P52333 L910S Disease 0.943 0.781 0.00 54 0.913 P52333 P132T Polymorphism 0.222 0.082 0.41 -22 0.113 P52333 P151R Disease 0.317 0.247 0.07 37 0.368 P52333 R582W Disease 0.645 0.681 0.01 14 0.761 P52333 V722I Polymorphism 0.204 0.329 0.01 13 0.222 P52333 Y100C Disease 0.821 0.715 0.00 51 0.900 P52569 V20M Polymorphism NA 0.324 0.15 -28 0.361 P52569 A531T Polymorphism 0.298 0.309 0.33 -32 0.267 P52630 Q66H Polymorphism NA 0.452 0.21 14 0.419 P52630 M594I Polymorphism 0.073 0.161 0.34 -4 0.124 P52630 S501I Polymorphism 0.936 0.963 0.01 24 0.920 P52701 A25V Polymorphism NA 0.189 NA -29 0.055 P52701 G39E Polymorphism NA 0.128 NA 17 0.121 P52701 K13T Polymorphism NA 0.258 NA 27 0.241 P52701 S65L Polymorphism NA 0.132 NA 9 0.028 P52701 E220D Polymorphism NA 0.089 0.03 -8 0.080 P52701 E221D Polymorphism NA 0.108 0.14 5 0.090 P52701 I886V Polymorphism NA 0.144 0.06 7 0.243 P52701 K728T Polymorphism NA 0.500 0.15 1 0.444 P52701 K854M Polymorphism NA 0.097 0.03 43 0.282 P52701 L396V Polymorphism NA 0.655 0.07 15 0.506 P52701 M492V Disease NA 0.260 0.08 42 0.283 P52701 P623A Polymorphism NA 0.314 0.06 0 0.297 P52701 Q698E Polymorphism NA 0.540 0.52 6 0.373 P52701 R468H Polymorphism NA 0.236 0.09 -2 0.203 P52701 R772W Disease NA 0.885 0.00 67 0.915 P52701 S144I Polymorphism NA 0.181 NA 35 0.163 P52701 S503C Polymorphism NA 0.651 0.00 27 0.762 P52701 S580L Polymorphism NA 0.347 0.04 29 0.421 P52701 V509A Polymorphism NA 0.800 0.00 34 0.847 P52701 V800L Polymorphism NA 0.258 0.30 -30 0.170 P52701 Y538S Polymorphism NA 0.542 0.40 36 0.517 P52701 D1213V Polymorphism 0.998 0.941 0.00 66 0.953 P52701 E1163V Disease 0.352 0.213 0.01 18 0.356 P52701 E1234Q Polymorphism 0.148 0.380 0.12 -21 0.284 P52701 R1321G Polymorphism 0.281 0.331 0.14 11 0.366 P52701 V1232L Polymorphism 0.104 0.519 0.27 -45 0.107 P52701 V1260I Polymorphism 0.176 0.094 0.06 -28 0.191 P52735 M594V Polymorphism 0.143 0.124 0.41 3 0.060 P52736 G194E Polymorphism 0.192 0.595 0.74 28 0.366 P52738 A386V Polymorphism 0.325 0.212 0.20 -34 0.301 P52740 G203D Polymorphism NA 0.599 0.62 2 0.162 P52740 P252L Polymorphism 0.508 0.369 0.32 0 0.093 P52741 A46T Polymorphism 0.101 0.242 0.08 -35 0.146 P52742 T517A Polymorphism 0.863 0.233 0.02 26 0.555 P52743 Q181H Polymorphism 0.551 0.317 0.00 7 0.067 P52746 L956H Polymorphism NA 0.143 0.72 41 0.241 P52746 A1313T Polymorphism NA 0.077 0.62 -31 0.131 P52747 E561Q Polymorphism NA 0.041 1.00 37 0.055 P52757 H204R Polymorphism 0.124 0.269 0.40 25 0.219 P52789 A314V Polymorphism 0.346 0.450 0.65 24 0.378 P52789 D881N Polymorphism NA 0.657 0.03 -34 0.486 P52789 L148F Polymorphism 0.537 0.611 0.17 2 0.489 P52789 Q142H Polymorphism 0.280 0.132 0.26 -23 0.195 P52789 R353C Polymorphism 0.504 0.742 0.18 43 0.811 P52789 R775Q Polymorphism NA 0.473 0.25 -11 0.325 P52789 R801Q Polymorphism NA 0.581 0.23 4 0.444 P52824 P27L Polymorphism NA 0.225 0.03 21 0.177 P52945 C18R Disease NA 0.614 0.01 64 0.811 P52945 D76N Disease 0.017 0.145 0.52 59 0.115 P52945 Q59L Disease NA 0.149 0.74 46 0.140 P52945 R197H Disease 0.999 0.807 0.00 72 0.912 P52952 L7P Disease NA 0.194 0.14 4 0.328 P52952 A63V Disease NA 0.228 0.34 12 0.204 P52952 E21Q Disease NA 0.255 0.29 38 0.366 P52952 F51L Disease NA 0.083 0.69 -22 0.075 P52952 K15I Disease NA 0.281 0.05 21 0.384 P52952 L69P Disease NA 0.374 0.34 29 0.222 P52952 N19S Disease NA 0.191 0.78 -32 0.145 P52952 P77L Disease NA 0.232 0.42 15 0.258 P52952 Q22P Disease NA 0.427 0.08 -21 0.498 P52952 R25C Disease NA 0.177 0.06 39 0.323 P52952 S45P Disease NA 0.260 0.47 -6 0.180 P52952 A119S Disease 0.185 0.278 0.98 -24 0.201 P52952 A127E Disease NA 0.241 0.83 27 0.292 P52952 A135T Disease 0.292 0.100 0.60 13 0.230 P52952 A219V Disease 0.534 0.346 0.30 14 0.569 P52952 A281V Disease NA 0.236 0.50 20 0.162 P52952 A286V Disease 0.112 0.172 0.37 16 0.118 P52952 A323T Disease 0.110 0.177 0.00 -6 0.139 P52952 C114R Disease 0.243 0.810 0.62 58 0.732 P52952 C114S Disease 0.210 0.735 0.99 3 0.392 P52952 D226N Disease 0.662 0.810 0.53 24 0.787 P52952 D299G Disease 0.128 0.182 1.00 45 0.132 P52952 E126V Disease NA 0.232 0.22 42 0.354 P52952 G320S Disease 0.108 0.493 0.00 35 0.269 P52952 K118R Disease 0.317 0.251 0.32 -10 0.250 P52952 K124R Disease NA 0.257 0.52 1 0.246 P52952 K183E Disease 0.960 0.908 0.00 55 0.918 P52952 K192R Disease 0.638 0.619 0.00 53 0.870 P52952 K192T Disease 0.930 0.729 0.00 64 0.922 P52952 K194R Disease 0.638 0.490 0.19 50 0.574 P52952 L144P Disease 0.800 0.708 0.30 29 0.607 P52952 N188K Disease 0.971 0.800 0.00 72 0.909 P52952 N294H Disease 0.206 0.376 0.05 45 0.243 P52952 P133S Disease 0.191 0.451 0.49 11 0.275 P52952 P275T Disease 0.144 0.168 0.25 41 0.178 P52952 Q187H Disease 0.984 0.773 0.00 71 0.927 P52952 R142C Disease 0.991 0.930 0.00 69 0.944 P52952 R161P Disease 0.932 0.929 0.06 22 0.830 P52952 R189G Disease 0.896 0.755 0.00 74 0.921 P52952 R190C Disease 0.999 0.888 0.00 76 0.949 P52952 R216C Disease 0.979 0.436 0.09 46 0.904 P52952 R322Q Disease 0.132 0.296 0.00 36 0.450 P52952 S279F Disease 0.525 0.312 0.06 36 0.471 P52952 S279P Disease 0.309 0.213 0.29 32 0.129 P52952 S305G Disease NA 0.045 0.37 24 0.081 P52952 T178M Disease 0.977 0.846 0.00 46 0.833 P52952 V205E Disease 0.426 0.171 0.88 40 0.153 P52952 Y191C Disease 0.979 0.430 0.02 61 0.978 P52952 Y248H Disease 0.467 0.493 0.48 37 0.561 P53350 L261F Polymorphism 0.551 0.303 0.09 -8 0.172 P53350 N297D Polymorphism 0.415 0.097 0.72 -50 0.093 P53350 R518H Polymorphism 0.511 0.345 0.11 7 0.541 P53350 S595L Polymorphism NA 0.185 0.01 34 0.351 P53355 D994E Polymorphism 0.258 0.116 NA -31 0.100 P53355 K978N Polymorphism 0.411 0.201 NA 36 0.371 P53355 M941T Polymorphism 0.289 0.307 NA 29 0.479 P53355 R977W Polymorphism 0.831 0.441 NA 58 0.670 P53355 S519A Polymorphism 0.073 0.087 0.37 42 0.086 P53355 L1008P Polymorphism 0.608 0.546 NA 41 0.740 P53355 R1010C Polymorphism 0.600 0.053 NA 16 0.086 P53355 T1018A Polymorphism 0.144 0.047 NA -7 0.066 P53370 C114R Polymorphism 0.446 0.236 0.26 25 0.109 P53396 E175D Polymorphism 0.116 0.100 0.54 -35 0.106 P53420 I6T Polymorphism NA 0.144 NA -50 0.170 P53420 E570Q Polymorphism NA 0.737 0.48 -23 0.425 P53420 E594G Polymorphism NA 0.614 0.36 30 0.544 P53420 G116E Disease NA 0.737 0.00 70 0.939 P53420 G897E Disease NA 0.557 0.00 62 0.896 P53420 G960R Disease 0.083 0.818 0.02 66 0.870 P53420 G999E Disease 0.522 0.870 0.00 68 0.987 P53420 P482S Polymorphism NA 0.510 0.71 20 0.412 P53420 G1030V Disease 0.998 0.695 0.00 60 0.970 P53420 G1201S Disease 0.390 0.812 0.60 -39 0.579 P53420 P1132L Disease 0.239 0.533 0.02 14 0.381 P53420 P1572L Disease NA 0.658 0.00 3 0.562 P53634 W39S Disease NA 0.844 0.00 58 0.860 P53634 C291Y Disease 0.318 0.949 0.00 75 0.747 P53634 D236Y Disease 0.696 0.921 0.00 63 0.920 P53634 E319G Disease 0.432 0.636 0.25 36 0.501 P53634 E401K Polymorphism NA 0.528 0.56 33 0.488 P53634 E447G Disease 0.392 0.301 0.01 49 0.581 P53634 G139R Disease NA 0.537 0.01 21 0.714 P53634 G300D Disease 0.569 0.924 0.00 70 0.658 P53634 G300S Disease 0.336 0.908 0.08 53 0.596 P53634 G301S Disease 0.422 0.899 0.01 60 0.638 P53634 G301V Disease 0.629 0.890 0.00 69 0.700 P53634 H127P Disease NA 0.374 0.01 64 0.707 P53634 H405N Disease 0.687 0.924 0.00 74 0.764 P53634 H405R Disease 0.622 0.873 0.00 77 0.753 P53634 Q252L Disease 0.610 0.891 0.00 43 0.856 P53634 Q286R Disease 0.443 0.837 0.02 67 0.716 P53634 Q312R Disease 0.200 0.343 0.63 -16 0.164 P53634 R272H Disease 0.445 0.589 0.02 0 0.486 P53634 R272P Disease 0.525 0.921 0.24 52 0.885 P53634 R339C Disease 0.805 0.575 0.05 21 0.702 P53634 V129E Disease NA 0.512 0.03 9 0.488 P53634 V249F Disease 0.637 0.924 0.02 39 0.872 P53634 W429C Disease 0.898 0.939 0.00 71 0.731 P53634 Y294H Disease 0.383 0.276 0.55 5 0.374 P53634 Y304N Disease 0.696 0.708 0.16 17 0.749 P53634 Y340C Disease 0.843 0.557 0.20 -4 0.722 P53634 Y347C Disease 0.870 0.616 0.17 6 0.762 P53634 Y412C Disease 0.841 0.920 0.00 67 0.906 P53667 F580Y Polymorphism 0.122 0.113 1.00 -36 0.093 P53667 G190A Polymorphism NA 0.156 0.31 23 0.242 P53667 R422Q Polymorphism 0.144 0.218 0.38 -3 0.172 P53667 S247N Polymorphism NA 0.250 0.03 41 0.378 P53671 G35S Polymorphism NA 0.099 0.45 -28 0.049 P53671 P296R Polymorphism NA 0.219 0.05 5 0.350 P53671 R381H Polymorphism 0.651 0.255 0.00 36 0.614 P53671 R418C Polymorphism 0.551 0.658 0.00 7 0.727 P53673 L69P Disease 0.898 0.918 0.00 53 0.932 P53675 P61L Polymorphism 0.205 0.352 0.39 19 0.330 P53675 E691K Polymorphism 0.419 0.249 0.05 37 0.386 P53675 K941R Polymorphism 0.493 0.531 0.00 29 0.486 P53675 R945H Polymorphism 0.654 0.902 0.00 48 0.838 P53675 I1394T Polymorphism 0.340 0.544 0.24 -3 0.438 P53675 R1046C Polymorphism 0.886 0.845 0.00 43 0.899 P53675 V1592M Polymorphism 0.131 0.052 0.39 -49 0.074 P53701 R217C Disease 0.975 0.987 0.00 57 0.953 P53708 I993V Polymorphism 0.094 0.079 0.82 -16 0.090 P53708 V567L Polymorphism 0.078 0.273 0.04 -3 0.159 P53778 D230N Polymorphism 0.681 0.642 0.16 4 0.649 P53778 T103M Polymorphism 0.251 0.359 0.05 -29 0.417 P53778 T244M Polymorphism NA 0.787 0.00 44 0.780 P53804 M840T Polymorphism NA 0.031 NA -22 0.010 P53804 P1154S Polymorphism NA 0.022 NA -26 0.028 P53804 S1063T Polymorphism NA 0.157 NA 48 0.120 P53814 A547P Polymorphism NA 0.105 0.27 -35 0.018 P53814 A559V Polymorphism NA 0.119 0.02 -24 0.077 P53814 A580T Polymorphism NA 0.148 0.00 28 0.156 P53985 G472R Disease 0.060 0.105 0.50 25 0.138 P53985 K204E Disease 0.106 0.337 0.97 -4 0.211 P53992 P109S Polymorphism NA 0.148 0.13 -2 0.126 P54098 R3P Disease NA 0.584 0.00 18 0.569 P54098 P18S Polymorphism NA 0.172 0.00 5 0.047 P54098 A467T Disease 0.195 0.365 0.13 4 0.254 P54098 A767D Disease 0.796 0.660 0.03 34 0.773 P54098 A889T Disease 0.810 0.960 0.00 50 0.929 P54098 A957P Disease 0.845 0.987 0.00 34 0.878 P54098 A957S Disease 0.349 0.931 0.00 9 0.578 P54098 E662K Polymorphism 0.211 0.047 0.83 -18 0.069 P54098 G268A Disease 0.421 0.935 0.00 21 0.774 P54098 G380D Disease 0.454 0.444 0.63 44 0.334 P54098 G431V Disease 0.510 0.871 0.03 49 0.876 P54098 G517V Disease 0.390 0.139 0.00 8 0.135 P54098 G737R Disease 0.162 0.725 0.02 -1 0.561 P54098 G848S Disease 0.906 0.941 0.00 57 0.951 P54098 G923D Disease 0.944 0.974 0.00 19 0.914 P54098 H932Y Disease 0.904 0.948 0.00 44 0.914 P54098 L244P Disease 0.448 0.965 0.00 31 0.828 P54098 L304R Disease 0.556 0.686 0.01 45 0.787 P54098 L463F Polymorphism 0.320 0.510 0.00 47 0.623 P54098 M603L Disease 0.179 0.072 1.00 -33 0.064 P54098 N468D Disease 0.140 0.090 0.61 -53 0.109 P54098 N864S Disease 0.860 0.923 0.00 47 0.881 P54098 P587L Disease 0.902 0.369 0.04 -11 0.595 P54098 P648R Disease 0.331 0.604 0.00 33 0.696 P54098 Q308H Disease 0.500 0.804 0.00 59 0.893 P54098 Q879H Disease 0.742 0.544 0.03 34 0.711 P54098 R227W Disease 0.744 0.242 0.10 -14 0.428 P54098 R232G Disease 0.645 0.384 0.17 29 0.422 P54098 R232H Disease 0.672 0.261 0.08 1 0.453 P54098 R309L Disease 0.375 0.920 0.02 47 0.807 P54098 R562Q Disease 0.469 0.228 0.00 23 0.407 P54098 R574W Disease 0.803 0.668 0.00 8 0.752 P54098 R579W Disease 0.806 0.235 0.00 8 0.548 P54098 R627W Disease 0.878 0.592 0.01 42 0.765 P54098 R807C Disease 0.973 0.975 0.00 56 0.972 P54098 R807P Disease 0.943 0.988 0.00 52 0.953 P54098 R853W Disease 0.980 0.964 0.00 70 0.972 P54098 R943H Disease 0.938 0.963 0.00 60 0.962 P54098 R953C Disease 0.973 0.966 0.00 57 0.973 P54098 S511N Disease 0.376 0.101 0.46 -32 0.178 P54098 T251I Disease NA 0.158 0.13 6 0.229 P54098 T885S Disease 0.200 0.114 0.68 -57 0.074 P54098 W312R Disease 0.251 0.896 0.01 36 0.699 P54098 W748S Disease 0.317 0.500 0.30 20 0.480 P54098 Y831C Disease 0.449 0.351 0.17 16 0.396 P54098 Y955C Disease 0.970 0.963 0.00 75 0.972 P54098 A1105T Disease 0.694 0.655 0.03 37 0.760 P54098 D1184N Disease 0.653 0.752 0.02 46 0.804 P54098 E1143G Polymorphism 0.738 0.657 0.04 17 0.740 P54098 G1051R Disease 0.831 0.908 0.03 42 0.863 P54098 G1076V Disease 0.910 0.940 0.01 28 0.899 P54098 K1191N Disease 0.892 0.885 0.00 53 0.943 P54098 Q1236H Polymorphism 0.305 0.049 0.00 16 0.083 P54098 R1047Q Disease 0.468 0.295 0.41 26 0.375 P54098 R1096C Disease 0.922 0.934 0.00 54 0.946 P54098 R1096H Disease 0.842 0.867 0.00 47 0.884 P54098 R1146C Disease 0.823 0.431 0.01 22 0.637 P54098 S1104C Disease 0.887 0.921 0.02 48 0.906 P54098 S1176L Disease 0.792 0.940 0.01 9 0.862 P54098 V1106I Disease 0.568 0.889 0.00 20 0.824 P54108 A134S Polymorphism 0.125 0.427 1.00 -20 0.224 P54108 S106P Polymorphism 0.329 0.600 1.00 -22 0.347 P54132 C878R Disease 0.525 0.500 0.06 48 0.546 P54132 C901Y Disease 0.852 0.736 0.00 48 0.873 P54132 G891E Disease 0.923 0.832 0.02 58 0.914 P54132 I841T Disease 0.452 0.769 0.03 22 0.590 P54132 P868L Polymorphism 0.779 0.308 0.14 30 0.587 P54132 Q672R Disease 0.995 0.837 0.00 70 0.940 P54132 R591Q Polymorphism NA 0.053 0.58 -7 0.045 P54132 T843I Disease 0.279 0.156 0.11 -38 0.252 P54132 C1036F Disease 0.949 0.950 0.00 66 0.941 P54132 C1055S Disease 0.132 0.822 0.03 55 0.633 P54132 E1213K Polymorphism 0.292 0.588 0.00 35 0.507 P54132 V1205I Polymorphism 0.142 0.166 0.05 19 0.132 P54219 F82C Polymorphism NA 0.272 0.01 29 0.358 P54219 S98T Polymorphism NA 0.082 0.77 -18 0.079 P54219 A101P Polymorphism NA 0.234 0.17 35 0.236 P54219 I202T Polymorphism 0.691 0.540 0.05 8 0.726 P54253 P753S Polymorphism NA 0.192 0.00 3 0.227 P54257 A488V Polymorphism 0.115 0.292 0.26 27 0.285 P54257 L408F Polymorphism 0.427 0.287 0.01 47 0.416 P54257 R437W Polymorphism 0.857 0.239 0.01 2 0.522 P54257 S357L Polymorphism 0.509 0.246 0.27 3 0.528 P54257 T493M Polymorphism 0.647 0.056 0.08 -37 0.073 P54277 E720D Polymorphism 0.182 0.079 NA 8 0.080 P54277 N632S Polymorphism 0.695 0.318 0.00 32 0.418 P54277 R202K Polymorphism 0.199 0.362 0.56 -25 0.159 P54278 R20Q Polymorphism NA 0.179 0.47 23 0.162 P54278 E705K Disease 0.842 0.974 0.00 63 0.952 P54278 H479Q Polymorphism 0.230 0.032 0.28 -22 0.030 P54278 M622I Polymorphism 0.244 0.221 0.32 -7 0.217 P54278 N775S Polymorphism NA 0.215 0.51 42 0.301 P54278 P470S Polymorphism 0.252 0.107 0.53 -34 0.093 P54278 T277K Polymorphism 0.256 0.602 0.24 56 0.462 P54278 T485K Polymorphism 0.360 0.085 0.02 7 0.097 P54278 T511A Polymorphism 0.194 0.045 0.66 -43 0.060 P54278 T597S Polymorphism 0.304 0.087 0.72 -15 0.064 P54284 R423H Polymorphism 0.124 0.071 0.17 -16 0.059 P54296 N869S Polymorphism 0.131 0.439 0.54 31 0.176 P54296 S601Y Polymorphism NA 0.583 0.01 35 0.765 P54296 T182M Polymorphism NA 0.201 0.08 29 0.257 P54296 V321L Polymorphism NA 0.345 0.57 44 0.400 P54296 E1284D Polymorphism 0.119 0.284 0.64 -7 0.200 P54296 L1022F Polymorphism 0.461 0.182 0.28 47 0.251 P54315 N61D Polymorphism 0.372 0.355 0.45 28 0.316 P54315 A271V Polymorphism NA 0.686 0.20 -3 0.475 P54315 E414D Polymorphism 0.147 0.263 0.15 -23 0.163 P54315 L461P Polymorphism 0.808 0.446 0.01 24 0.543 P54368 G44D Polymorphism 0.220 0.113 0.54 24 0.074 P54368 R32L Polymorphism 0.137 0.051 0.25 27 0.041 P54368 S50F Polymorphism 0.439 0.100 0.06 7 0.082 P54577 G41R Disease 0.927 0.910 0.00 66 0.943 P54577 E196K Disease 0.190 0.843 0.21 30 0.432 P54577 Q170H Polymorphism 0.892 0.860 0.00 76 0.942 P54619 K329N Polymorphism NA 0.041 0.04 -16 0.100 P54652 C191S Polymorphism NA 0.104 0.97 -49 0.070 P54652 K496E Polymorphism 0.364 0.957 0.01 11 0.551 P54687 T59M Polymorphism 0.311 0.445 0.53 -24 0.292 P54687 G330S Polymorphism 0.595 0.752 0.08 42 0.829 P54707 P863L Polymorphism NA 0.500 0.18 15 0.431 P54710 G41R Disease 0.887 0.858 0.01 69 0.936 P54725 R179Q Polymorphism 0.265 0.086 0.69 -37 0.091 P54725 T131A Polymorphism 0.209 0.073 0.32 -26 0.141 P54725 T200M Polymorphism 0.211 0.204 0.10 -6 0.228 P54753 I579V Polymorphism 0.135 0.338 0.70 -30 0.250 P54753 I601L Polymorphism 0.103 0.336 0.70 -22 0.179 P54753 R440C Polymorphism 0.569 0.643 0.03 46 0.779 P54756 N81T Polymorphism 0.224 0.383 0.48 -6 0.254 P54756 A672T Polymorphism NA 0.422 0.30 -39 0.493 P54756 E330Q Polymorphism 0.158 0.161 0.50 -17 0.181 P54756 H959R Polymorphism 0.121 0.089 0.92 1 0.107 P54756 S235A Polymorphism 0.130 0.207 0.93 -37 0.220 P54756 S673T Polymorphism NA 0.487 0.17 3 0.413 P54756 Y506C Polymorphism 0.925 0.954 0.00 47 0.930 P54760 P67L Polymorphism 0.586 0.856 0.02 0 0.647 P54760 A371V Polymorphism 0.106 0.187 0.31 7 0.163 P54760 A882T Polymorphism 0.513 0.470 0.50 -3 0.475 P54760 D576E Polymorphism 0.211 0.391 0.76 -20 0.263 P54760 E890D Polymorphism 0.296 0.149 0.29 -17 0.205 P54760 R678H Polymorphism 0.127 0.805 0.41 -8 0.231 P54760 V113I Polymorphism 0.168 0.287 0.03 -26 0.265 P54762 M18V Polymorphism 0.169 0.102 0.37 -38 0.103 P54762 T87S Polymorphism 0.215 0.615 0.00 3 0.390 P54762 A912T Polymorphism 0.133 0.328 0.52 -19 0.181 P54762 G152R Polymorphism 0.581 0.958 0.02 27 0.791 P54762 M847T Polymorphism 0.534 0.323 0.15 11 0.587 P54762 R367G Polymorphism 0.127 0.561 0.44 44 0.224 P54762 R485S Polymorphism 0.110 0.747 0.03 28 0.387 P54762 R973W Polymorphism NA 0.953 0.00 41 0.867 P54762 T387M Polymorphism 0.405 0.477 0.02 30 0.518 P54762 T981M Polymorphism NA 0.094 0.05 -25 0.090 P54764 R269Q Polymorphism 0.195 0.208 0.60 17 0.243 P54764 R953K Polymorphism NA 0.694 0.48 0 0.483 P54793 H527Y Polymorphism 0.171 0.351 1.00 -28 0.186 P54802 F48C Disease 0.536 0.871 NA 32 0.847 P54802 F48L Disease 0.203 0.856 NA 16 0.503 P54802 G69S Disease 0.199 0.231 NA -51 0.226 P54802 G79C Disease 0.835 0.779 NA 53 0.873 P54802 G79S Disease 0.525 0.853 NA 48 0.868 P54802 G82D Disease 0.194 0.700 NA 29 0.461 P54802 L35F Disease 0.478 0.560 NA 1 0.488 P54802 R38W Disease 0.675 0.851 NA 66 0.912 P54802 V77G Disease 0.841 0.615 NA 28 0.781 P54802 Y92H Disease 0.848 0.938 NA 62 0.901 P54802 A246P Disease 0.792 0.802 NA 6 0.694 P54802 A664V Disease 0.637 0.394 NA 30 0.623 P54802 C277F Disease 0.748 0.811 NA 36 0.845 P54802 E153K Disease 0.320 0.842 NA 45 0.771 P54802 E446K Disease 0.824 0.930 NA 64 0.942 P54802 E452K Disease 0.268 0.166 NA 2 0.271 P54802 E705K Disease 0.583 0.616 NA 15 0.522 P54802 F314L Disease 0.720 0.929 NA 30 0.712 P54802 F410S Disease 0.901 0.953 NA 59 0.940 P54802 G292R Disease 0.573 0.743 NA 38 0.823 P54802 G412E Disease 0.923 0.958 NA 64 0.939 P54802 G650E Disease 0.776 0.949 NA 60 0.849 P54802 H100R Disease 0.291 0.693 NA 45 0.740 P54802 H227P Disease 0.431 0.736 NA 30 0.778 P54802 H248R Disease 0.501 0.611 NA 37 0.776 P54802 H414R Disease 0.134 0.225 NA 20 0.263 P54802 I154R Disease 0.906 0.887 NA 46 0.914 P54802 L242P Disease 0.931 0.981 NA 37 0.904 P54802 L280P Disease 0.727 0.810 NA 18 0.817 P54802 L560P Disease 0.905 0.980 NA 51 0.933 P54802 L561R Disease 0.585 0.799 NA 18 0.833 P54802 L591P Disease 0.837 0.867 NA 13 0.807 P54802 L617F Disease 0.649 0.590 NA 30 0.765 P54802 L682R Disease 0.592 0.971 NA 18 0.648 P54802 P115S Disease 0.506 0.772 NA -15 0.580 P54802 P243L Disease 0.936 0.895 NA 38 0.905 P54802 P358L Disease 0.337 0.280 NA 0 0.356 P54802 P516L Disease 0.154 0.087 NA -51 0.111 P54802 P521L Disease 0.506 0.889 NA 51 0.878 P54802 R130C Disease 0.846 0.901 NA 61 0.926 P54802 R234C Disease 0.903 0.826 NA 43 0.885 P54802 R482Q Disease 0.840 0.928 NA 68 0.939 P54802 R482W Disease 0.972 0.969 NA 67 0.954 P54802 R520W Disease 0.925 0.862 NA 57 0.929 P54802 R565P Disease 0.921 0.978 NA 65 0.941 P54802 R565Q Disease 0.840 0.766 NA 51 0.869 P54802 R565W Disease 0.972 0.910 NA 53 0.945 P54802 R643C Disease 0.858 0.903 NA 51 0.918 P54802 R643H Disease 0.747 0.827 NA 44 0.850 P54802 R674C Disease 0.962 0.975 NA 63 0.953 P54802 R674H Disease 0.912 0.960 NA 64 0.940 P54802 R676P Disease 0.687 0.741 NA 7 0.757 P54802 S534Y Disease 0.562 0.425 NA -35 0.609 P54802 S612G Disease 0.575 0.520 NA -16 0.488 P54802 T437I Disease 0.721 0.469 NA 29 0.685 P54802 V241M Disease 0.705 0.702 NA 30 0.845 P54802 V334F Disease 0.705 0.730 NA 33 0.841 P54802 V501G Disease 0.867 0.784 NA 26 0.859 P54802 W156C Disease 0.969 0.942 NA 51 0.935 P54802 W268R Disease 0.861 0.975 NA 60 0.938 P54802 W474G Disease 0.914 0.969 NA 55 0.939 P54802 W649C Disease 0.969 0.981 NA 61 0.936 P54802 Y140C Disease 0.958 0.970 NA 79 0.948 P54802 Y309C Disease 0.947 0.963 NA 67 0.941 P54802 Y335C Disease 0.890 0.609 NA 43 0.798 P54802 Y455C Disease 0.946 0.956 NA 53 0.940 P54802 Y658F Disease 0.610 0.939 NA 63 0.931 P54803 G59R Disease 0.850 0.779 0.00 79 0.927 P54803 I82M Disease 0.479 0.495 0.02 28 0.496 P54803 R79H Disease 0.565 0.724 0.00 45 0.824 P54803 S68F Disease 0.821 0.856 0.00 43 0.864 P54803 A263T Disease 0.430 0.516 0.00 45 0.560 P54803 A592S Disease 0.264 0.314 0.00 -26 0.233 P54803 D187V Disease 0.608 0.716 0.01 20 0.779 P54803 D248N Polymorphism 0.200 0.779 0.00 52 0.641 P54803 D544N Disease 0.390 0.523 0.00 2 0.444 P54803 F514S Disease 0.712 0.940 0.00 31 0.854 P54803 G111D Disease 0.590 0.863 0.00 37 0.826 P54803 G111S Disease 0.347 0.857 0.00 31 0.691 P54803 G194A Disease 0.661 0.797 0.00 48 0.715 P54803 G284S Disease 0.566 0.852 0.00 21 0.627 P54803 G286D Disease 0.155 0.745 0.00 27 0.614 P54803 G553R Disease 0.544 0.920 0.00 68 0.920 P54803 I250T Disease 0.470 0.910 0.00 44 0.827 P54803 I562T Polymorphism 0.354 0.689 0.03 19 0.575 P54803 I599S Disease 0.579 0.866 0.00 30 0.821 P54803 L634S Disease 0.440 0.714 0.00 31 0.744 P54803 L645R Disease 0.818 0.838 0.00 46 0.874 P54803 M117L Disease 0.290 0.620 0.36 25 0.595 P54803 N295T Disease 0.425 0.713 0.00 36 0.729 P54803 P318A Disease 0.248 0.490 0.00 47 0.523 P54803 P400L Disease 0.498 0.463 0.00 5 0.403 P54803 R396W Disease 0.771 0.690 0.00 54 0.885 P54803 R531C Disease 0.778 0.860 0.00 57 0.912 P54803 R531H Disease 0.585 0.788 0.00 50 0.842 P54803 S303F Disease 0.451 0.567 0.02 27 0.709 P54803 T112A Disease 0.322 0.405 0.00 -15 0.240 P54803 T278I Disease 0.535 0.559 0.00 18 0.479 P54803 T468S Disease 0.396 0.737 0.00 33 0.603 P54803 T529M Disease 0.629 0.352 0.00 31 0.569 P54803 T668R Disease 0.410 0.739 0.00 57 0.837 P54803 V566G Disease 0.708 0.844 0.00 36 0.852 P54803 W426G Disease 0.716 0.929 0.00 59 0.930 P54803 Y314C Disease 0.760 0.972 0.00 56 0.928 P54803 Y335C Disease 0.842 0.930 0.00 57 0.939 P54803 Y567S Disease 0.176 0.598 0.00 13 0.378 P54819 D165G Disease 0.671 0.748 0.55 32 0.865 P54819 R103W Disease 0.990 0.944 0.00 66 0.953 P54829 H561R Polymorphism NA 0.736 0.50 0 0.435 P54840 N39S Disease 0.547 0.906 0.03 39 0.849 P54840 A193T Polymorphism 0.159 0.145 0.56 -43 0.101 P54840 A339P Disease 0.674 0.901 0.03 42 0.864 P54840 H446D Disease 0.831 0.915 0.00 65 0.942 P54840 M491R Disease 0.370 0.730 0.01 35 0.689 P54840 P479Q Disease 0.926 0.934 0.00 43 0.915 P54840 S483P Disease 0.596 0.946 0.02 31 0.851 P54845 S50T Disease 0.776 0.482 0.75 -22 0.599 P54849 S57N Polymorphism 0.108 0.086 0.51 15 0.108 P54852 I125V Polymorphism 0.141 0.127 0.57 20 0.110 P54868 V54M Disease 0.649 0.912 0.00 38 0.878 P54868 F174L Disease 0.163 0.746 1.00 -11 0.292 P54868 G212R Disease 0.837 0.927 0.00 69 0.943 P54868 R500H Disease 0.675 0.966 0.01 33 0.868 P54868 Y167C Disease 0.931 0.911 0.04 62 0.945 P54886 R84Q Disease 0.491 0.316 0.01 50 0.619 P54886 H784Y Disease 0.490 0.968 0.00 48 0.843 P54886 T299I Polymorphism 0.413 0.182 0.03 24 0.346 P55000 C77R Disease NA 0.662 0.00 73 0.812 P55000 C99Y Disease NA 0.822 0.00 60 0.908 P55000 G86R Disease NA 0.813 0.23 60 0.712 P55000 R71H Disease NA 0.170 0.03 45 0.223 P55000 W15R Disease NA 0.338 0.25 34 0.175 P55008 G14R Polymorphism 0.437 0.465 0.00 52 0.587 P55017 D62N Disease NA 0.573 0.03 25 0.594 P55017 E68K Disease NA 0.414 0.17 34 0.484 P55017 H69N Disease NA 0.181 0.33 10 0.167 P55017 H90Y Disease NA 0.770 0.05 7 0.556 P55017 T60M Disease NA 0.699 0.00 46 0.778 P55017 A226T Disease NA 0.923 0.02 22 0.827 P55017 A313V Disease NA 0.273 0.24 -4 0.242 P55017 A464T Disease NA 0.741 0.02 -1 0.514 P55017 A569E Disease 0.420 0.647 0.01 49 0.686 P55017 A569V Disease 0.320 0.542 0.38 -40 0.313 P55017 A588V Disease 0.320 0.839 0.31 14 0.619 P55017 C421R Disease NA 0.916 0.01 52 0.874 P55017 C985Y Disease 0.690 0.658 0.11 51 0.786 P55017 D486N Disease 0.859 0.965 0.00 40 0.889 P55017 G186D Disease NA 0.491 0.01 36 0.619 P55017 G230D Disease NA 0.821 0.01 38 0.773 P55017 G316V Disease NA 0.896 0.01 45 0.723 P55017 G342A Disease NA 0.539 0.67 -25 0.321 P55017 G374V Disease NA 0.894 0.00 48 0.872 P55017 G439S Disease NA 0.859 0.19 42 0.664 P55017 G463E Disease NA 0.591 0.15 34 0.771 P55017 G496C Disease 0.721 0.879 0.01 37 0.869 P55017 G613S Disease 0.902 0.896 0.00 49 0.922 P55017 G630V Disease 0.565 0.558 0.11 -10 0.697 P55017 G729V Disease NA 0.956 0.00 65 0.941 P55017 G731R Disease 0.598 0.979 0.00 61 0.917 P55017 G741R Disease 0.961 0.958 0.01 64 0.976 P55017 G867S Disease 0.423 0.554 0.27 -6 0.447 P55017 I154F Disease NA 0.870 0.03 34 0.831 P55017 K284R Disease NA 0.734 0.60 9 0.448 P55017 K478E Disease NA 0.695 0.02 68 0.896 P55017 L215P Disease NA 0.879 0.00 49 0.880 P55017 L542P Disease 0.675 0.901 0.01 44 0.848 P55017 L623P Disease 0.675 0.820 0.15 17 0.824 P55017 L738R Disease 0.564 0.829 0.00 48 0.875 P55017 L849H Disease 0.702 0.763 0.00 35 0.863 P55017 L850P Disease 0.698 0.966 0.00 49 0.906 P55017 M672I Disease 0.186 0.624 0.44 -18 0.298 P55017 P349L Disease NA 0.907 0.00 37 0.850 P55017 P560H Disease 0.997 0.931 0.00 55 0.954 P55017 P643L Disease 0.995 0.906 0.00 40 0.919 P55017 R145H Disease NA 0.680 0.13 51 0.840 P55017 R158Q Disease NA 0.941 0.00 59 0.894 P55017 R209Q Disease NA 0.857 0.00 48 0.838 P55017 R209W Disease NA 0.920 0.00 56 0.896 P55017 R261H Disease NA 0.788 0.01 64 0.879 P55017 R321W Disease NA 0.626 0.03 36 0.774 P55017 R334W Disease NA 0.727 0.04 12 0.725 P55017 R399C Disease NA 0.954 0.00 63 0.940 P55017 R642C Disease 0.748 0.960 0.00 51 0.915 P55017 R642G Disease 0.465 0.952 0.02 42 0.852 P55017 R642H Disease 0.531 0.925 0.01 16 0.648 P55017 R655C Disease 0.748 0.885 0.04 69 0.772 P55017 R655H Disease 0.531 0.764 0.47 63 0.699 P55017 R655L Disease 0.433 0.832 0.17 63 0.904 P55017 R852C Disease 0.769 0.641 0.03 40 0.814 P55017 R852H Disease 0.559 0.276 0.21 -9 0.492 P55017 R852S Disease 0.422 0.332 0.18 12 0.312 P55017 R871H Disease 0.559 0.359 0.15 18 0.586 P55017 R919C Polymorphism 0.769 0.922 0.00 57 0.735 P55017 R955Q Disease 0.849 0.876 0.17 62 0.840 P55017 R958G Disease 0.493 0.890 0.01 57 0.846 P55017 S178L Disease NA 0.712 0.03 13 0.732 P55017 S283Y Disease NA 0.632 0.01 46 0.756 P55017 S555L Disease 0.416 0.743 0.01 4 0.554 P55017 S615L Disease 0.416 0.681 0.09 15 0.543 P55017 S615W Disease 0.818 0.728 0.02 47 0.873 P55017 T163M Disease NA 0.500 0.01 -2 0.464 P55017 T180K Disease NA 0.436 0.17 48 0.544 P55017 T304P Disease NA 0.901 0.19 43 0.670 P55017 T649R Disease 0.415 0.695 0.04 61 0.871 P55017 V153M Disease NA 0.896 0.00 35 0.840 P55017 V578M Disease 0.424 0.604 0.15 25 0.626 P55017 V677L Disease 0.189 0.869 0.02 -4 0.507 P55017 V677M Disease 0.424 0.904 0.00 10 0.754 P55017 W172R Disease NA 0.611 0.02 46 0.767 P55040 R43G Polymorphism NA 0.053 0.26 27 0.083 P55042 Q66P Polymorphism 0.397 0.205 0.02 -4 0.218 P55056 L36P Polymorphism NA 0.038 0.11 -12 0.026 P55056 Q126L Polymorphism NA 0.157 0.00 25 0.264 P55058 R372H Polymorphism 0.461 0.119 0.10 45 0.279 P55058 R380W Polymorphism 0.785 0.140 0.02 48 0.477 P55060 I754V Polymorphism 0.145 0.122 0.24 -29 0.141 P55060 V968L Polymorphism NA 0.307 0.00 23 0.278 P55072 R95G Disease NA 0.489 0.43 23 0.402 P55072 A232E Disease 0.143 0.790 0.74 -1 0.178 P55072 R155C Disease NA 0.752 0.02 51 0.836 P55072 R155H Disease NA 0.453 0.13 13 0.445 P55072 R155P Disease NA 0.766 0.18 47 0.640 P55072 R159H Disease NA 0.467 0.16 9 0.406 P55072 R191Q Disease 0.319 0.490 0.57 21 0.402 P55075 F40L Disease NA 0.113 0.45 -41 0.041 P55075 H14N Disease 0.191 0.348 0.48 26 0.413 P55075 K89E Disease 0.448 0.604 0.05 43 0.736 P55075 P26L Disease 0.236 0.087 1.00 29 0.051 P55075 R116G Disease 0.821 0.906 0.50 32 0.846 P55075 T218M Disease 0.332 0.197 0.01 34 0.300 P55084 G59D Disease NA 0.826 0.00 54 0.885 P55084 R61C Disease NA 0.942 0.00 76 0.939 P55084 R61H Disease NA 0.911 0.00 76 0.923 P55084 D242G Disease 0.980 0.832 0.00 54 0.920 P55084 D263G Disease 0.509 0.621 0.12 31 0.533 P55084 G280D Disease 0.348 0.767 0.29 27 0.526 P55084 G301S Disease 0.453 0.873 0.00 52 0.883 P55084 L121P Disease 0.866 0.919 0.00 60 0.920 P55084 P294L Disease 0.828 0.895 0.00 39 0.873 P55084 P294R Disease 0.838 0.939 0.00 52 0.913 P55084 R117G Disease 0.985 0.926 0.00 63 0.925 P55084 R247H Disease 0.621 0.467 0.07 17 0.623 P55084 R444K Disease 0.172 0.678 0.03 -5 0.412 P55084 T133P Disease 0.498 0.896 0.01 55 0.895 P55085 N30S Polymorphism NA 0.123 0.71 -10 0.088 P55085 R270Q Polymorphism 0.211 0.537 0.54 30 0.340 P55085 T291A Polymorphism 0.164 0.060 0.57 -2 0.103 P55157 Q95H Polymorphism 0.215 0.092 0.00 10 0.178 P55157 D384A Polymorphism 0.165 0.129 0.80 12 0.116 P55157 G746E Disease 0.695 0.762 0.14 69 0.903 P55157 N780Y Disease 0.558 0.353 0.00 37 0.592 P55157 R540H Disease 0.594 0.671 0.00 68 0.844 P55157 S590I Disease 0.304 0.208 0.50 13 0.303 P55157 V168I Polymorphism 0.351 0.068 0.24 7 0.085 P55160 S402L Polymorphism 0.274 0.169 0.18 -13 0.231 P55201 G1117E Polymorphism 0.894 0.500 0.00 45 0.865 P55201 H1193Q Polymorphism 0.420 0.163 0.05 -23 0.130 P55210 D4E Polymorphism NA 0.135 0.00 -5 0.171 P55210 D255E Polymorphism 0.069 0.256 0.90 -30 0.199 P55211 A28V Polymorphism 0.162 0.091 0.63 4 0.154 P55211 E114D Polymorphism 0.133 0.154 0.52 -20 0.097 P55211 F136L Polymorphism 0.075 0.203 0.65 11 0.138 P55211 G176R Polymorphism 0.419 0.655 0.33 15 0.483 P55211 L106V Polymorphism 0.126 0.043 0.30 18 0.101 P55211 Q221R Polymorphism 0.072 0.390 0.19 -29 0.140 P55211 R173H Polymorphism 0.294 0.374 0.13 -24 0.362 P55211 R192C Polymorphism 0.594 0.655 0.04 11 0.575 P55212 E35K Polymorphism 0.268 0.825 0.65 25 0.516 P55265 C966F Disease 0.959 0.981 0.01 64 0.954 P55265 K384R Polymorphism NA 0.037 0.15 -2 0.053 P55265 L923P Disease 0.754 0.981 0.00 53 0.913 P55265 Y587C Polymorphism NA 0.126 0.21 -4 0.096 P55265 F1165S Disease 0.656 0.844 0.00 39 0.861 P55265 R1155W Disease 0.889 0.901 0.00 60 0.933 P55268 C321R Disease 0.999 0.853 0.00 79 0.993 P55268 E987K Polymorphism 0.297 0.310 0.87 27 0.225 P55268 R246Q Disease 0.910 0.870 0.00 60 0.920 P55268 R246W Disease 0.984 0.926 0.00 60 0.955 P55268 L1393F Disease 0.394 0.762 0.09 -19 0.541 P55268 N1380K Disease 0.356 0.750 0.44 21 0.512 P55283 A141V Polymorphism NA 0.298 0.30 -75 0.245 P55283 K625R Polymorphism 0.050 0.213 1.00 0 0.120 P55287 M275I Polymorphism 0.208 0.185 0.30 22 0.165 P55287 S373A Polymorphism 0.093 0.260 0.65 9 0.158 P55287 T255M Polymorphism 0.155 0.211 0.22 30 0.277 P55289 E86K Polymorphism NA 0.311 0.02 0 0.288 P55289 V68M Polymorphism 0.105 0.075 0.15 -1 0.178 P55289 I284V Polymorphism 0.056 0.180 1.00 -16 0.075 P55289 I475T Polymorphism 0.382 0.253 0.01 38 0.433 P55290 L121S Polymorphism NA 0.310 0.74 -59 0.269 P55291 V8L Disease 0.079 0.166 0.75 -45 0.052 P55291 R60C Disease 0.715 0.627 0.00 22 0.773 P55291 R92W Disease 0.790 0.508 0.05 32 0.750 P55291 A122V Disease 0.440 0.616 0.01 27 0.570 P55317 A83T Polymorphism NA 0.136 0.82 -1 0.123 P55318 G91R Polymorphism NA 0.209 0.39 22 0.333 P55347 T216A Polymorphism NA 0.231 0.81 7 0.238 P55735 S172L Polymorphism 0.122 0.632 0.35 2 0.133 P55769 T19N Polymorphism NA 0.325 0.20 -56 0.276 P55771 G51S Disease 0.878 0.886 0.00 49 0.875 P55771 A240P Polymorphism 0.235 0.229 0.01 11 0.304 P55809 T58M Polymorphism 0.564 0.560 0.01 18 0.570 P55809 C456F Disease 0.734 0.907 0.16 70 0.927 P55809 G219E Disease 0.908 0.916 0.00 63 0.949 P55809 G324E Disease 0.925 0.980 0.00 78 0.952 P55809 V133E Disease 0.669 0.643 0.01 41 0.817 P55809 V221M Disease 0.450 0.291 0.08 27 0.439 P55822 D50N Polymorphism NA 0.071 NA -34 0.010 P55822 V188A Polymorphism 0.146 0.039 0.35 -33 0.045 P55851 A55V Polymorphism NA 0.203 0.29 1 0.294 P55851 R76Q Polymorphism 0.228 0.361 0.40 26 0.355 P55854 P38S Polymorphism 0.310 0.314 0.12 5 0.335 P55884 S64P Polymorphism NA 0.088 1.00 -44 0.017 P55895 C41W Disease 0.915 0.521 0.00 48 0.838 P55895 T77N Disease 0.458 0.438 0.02 8 0.534 P55895 C478Y Disease 0.817 0.774 0.00 64 0.933 P55895 G451A Disease 0.564 0.523 0.00 36 0.748 P55895 M285R Disease 0.654 0.920 0.01 48 0.877 P55895 R229Q Disease 0.620 0.967 0.00 63 0.942 P56159 Y85N Polymorphism NA 0.620 0.07 37 0.577 P56159 T366A Polymorphism NA 0.122 0.45 -21 0.109 P56177 S136C Polymorphism 0.817 0.847 0.00 55 0.913 P56180 G549E Polymorphism 0.160 0.141 0.01 0 0.059 P56182 K326R Polymorphism 0.265 0.087 0.15 -21 0.179 P56192 A683D Polymorphism 0.362 0.576 0.52 -21 0.381 P56199 E1108G Polymorphism 0.301 0.801 0.03 41 0.735 P56202 Q218R Polymorphism 0.356 0.308 0.49 -1 0.186 P56202 S139G Polymorphism 0.180 0.026 1.00 -28 0.026 P56279 V56I Polymorphism NA 0.204 0.25 46 0.167 P56282 L456V Polymorphism 0.401 0.656 0.42 37 0.600 P56373 A383V Polymorphism 0.078 0.035 0.62 -10 0.022 P56470 T16M Polymorphism NA 0.369 0.08 -13 0.340 P56539 A46T Disease 0.515 0.907 0.01 31 0.797 P56539 A46V Disease 0.573 0.867 0.01 34 0.819 P56539 A85T Disease 0.400 0.702 0.12 41 0.594 P56539 A93T Disease 0.542 0.914 0.00 51 0.887 P56539 C72W Polymorphism 0.896 0.686 0.02 55 0.893 P56539 D28E Disease 0.810 0.873 0.00 54 0.926 P56539 F97C Disease 0.874 0.508 0.32 33 0.636 P56539 G56S Polymorphism 0.687 0.550 0.21 -9 0.686 P56539 L79R Disease 0.578 0.908 0.00 46 0.849 P56539 L87P Disease 0.722 0.887 0.01 43 0.824 P56539 N33K Disease 0.892 0.857 0.00 57 0.944 P56539 P29L Disease 0.949 0.783 0.00 25 0.886 P56539 R27Q Disease 0.900 0.828 0.00 68 0.944 P56539 S53G Disease 0.821 0.916 0.00 54 0.731 P56539 T64P Disease 0.733 0.909 0.05 37 0.865 P56539 T64S Disease 0.487 0.672 0.04 20 0.609 P56539 T78M Disease 0.456 0.251 0.07 12 0.395 P56539 V14L Disease 0.052 0.049 0.14 -28 0.056 P56539 V44E Disease 0.771 0.938 0.00 62 0.939 P56539 V57M Disease 0.537 0.664 0.00 51 0.733 P56539 P105L Disease 0.961 0.947 0.00 54 0.971 P56539 R126H Polymorphism 0.112 0.084 0.57 -7 0.074 P56539 S141R Disease 0.483 0.919 0.00 63 0.697 P56545 E47D Polymorphism 0.409 0.500 0.40 31 0.508 P56589 Q82R Polymorphism 0.398 0.090 0.22 -19 0.119 P56589 G138E Disease 0.377 0.869 0.32 50 0.839 P56645 V639G Polymorphism 0.373 0.757 0.23 16 0.688 P56645 H1149R Polymorphism 0.129 0.095 0.02 -3 0.105 P56645 M1028T Polymorphism 0.123 0.066 0.53 31 0.032 P56693 S135T Disease 0.997 0.841 0.00 49 0.928 P56696 G285C Disease 0.982 0.839 0.00 63 0.942 P56696 G285S Disease 0.947 0.867 0.00 47 0.907 P56696 G321S Disease 0.946 0.808 0.02 52 0.944 P56696 H455Q Polymorphism 0.049 0.101 0.58 10 0.145 P56696 L274H Disease 0.981 0.719 0.00 66 0.933 P56696 L281S Disease 0.402 0.629 0.00 56 0.713 P56696 W276S Disease 0.979 0.918 0.00 70 0.940 P56705 L12P Disease NA 0.867 0.12 -9 0.697 P56705 R83C Disease 0.829 0.946 0.00 43 0.887 P56705 A114V Disease 0.958 0.916 0.00 42 0.933 P56705 E216G Disease 0.491 0.302 0.02 39 0.498 P56715 R872H Polymorphism 0.296 0.063 0.01 26 0.093 P56715 T752M Polymorphism 0.362 0.144 0.24 19 0.020 P56715 V945L Polymorphism 0.324 0.121 0.05 34 0.058 P56715 Y251C Polymorphism 0.639 0.131 0.08 41 0.361 P56715 A1670T Polymorphism 0.113 0.039 0.46 -28 0.015 P56715 R1595Q Polymorphism 0.365 0.196 0.21 31 0.121 P56715 S1691P Polymorphism 0.515 0.058 0.14 30 0.033 P56748 T25A Polymorphism 0.579 0.739 0.39 16 0.846 P56851 L5V Polymorphism 0.414 0.075 NA 12 0.047 P56945 H558R Polymorphism 0.216 0.178 0.29 37 0.298 P56945 R491L Polymorphism 0.301 0.859 0.03 50 0.750 P56975 K552N Polymorphism 0.404 0.252 NA 32 0.175 P56975 S472R Polymorphism 0.199 0.243 0.02 38 0.284 P57054 Y118C Polymorphism 0.818 0.606 0.00 30 0.686 P57057 D247N Polymorphism 0.300 0.539 0.35 8 0.489 P57058 M648T Polymorphism NA 0.144 0.00 13 0.010 P57058 R591C Polymorphism NA 0.244 0.00 37 0.193 P57059 G15S Polymorphism NA 0.324 0.43 -40 0.263 P57059 A615V Polymorphism NA 0.068 0.09 29 0.071 P57071 T1376S Polymorphism NA 0.158 0.04 36 0.034 P57071 V1342I Polymorphism NA 0.219 0.02 33 0.208 P57075 L28F Polymorphism 0.127 0.436 0.00 54 0.547 P57075 S18G Polymorphism 0.077 0.037 0.67 -22 0.044 P57075 D466E Polymorphism 0.080 0.072 1.00 -59 0.027 P57077 I112V Polymorphism NA 0.038 0.69 -28 0.018 P57078 A12G Polymorphism NA 0.064 0.82 -32 0.013 P57078 R669H Polymorphism 0.465 0.361 0.41 38 0.442 P57078 S177N Polymorphism NA 0.214 0.45 7 0.335 P57078 V463M Polymorphism NA 0.152 0.23 31 0.276 P57081 K71N Polymorphism NA 0.189 0.15 -13 0.345 P57081 P266S Polymorphism 0.099 0.193 0.34 3 0.165 P57081 R390Q Polymorphism 0.110 0.052 NA 5 0.073 P57082 G6A Polymorphism NA 0.109 0.09 -36 0.073 P57082 A35V Polymorphism NA 0.153 0.21 -15 0.193 P57082 G248V Disease 0.997 0.886 0.00 57 0.954 P57082 Q531R Disease 0.253 0.159 0.00 37 0.298 P57087 S286R Polymorphism NA 0.347 0.03 31 0.432 P57105 V9I Polymorphism 0.167 0.153 0.40 -5 0.127 P57678 F182L Polymorphism NA 0.364 NA 27 0.276 P57678 F782L Polymorphism NA 0.650 NA 48 0.694 P57678 R684Q Polymorphism NA 0.049 NA 33 0.055 P57678 R1033C Polymorphism NA 0.102 NA 37 0.093 P57679 Q74P Polymorphism NA 0.143 0.00 20 0.179 P57679 G403S Polymorphism 0.114 0.063 0.00 -32 0.082 P57679 R443Q Disease 0.158 0.117 0.35 -8 0.036 P57679 R576Q Polymorphism 0.109 0.126 0.37 30 0.088 P57679 R760Q Polymorphism 0.216 0.108 0.25 27 0.073 P57679 S307P Disease 0.637 0.174 0.00 51 0.328 P57679 T372M Polymorphism 0.314 0.112 0.04 -15 0.117 P57679 T449K Polymorphism 0.124 0.063 0.87 -37 0.009 P57679 Y258H Polymorphism 0.252 0.061 0.37 37 0.042 P57682 R207S Polymorphism NA 0.229 0.01 -4 0.213 P57723 G198S Polymorphism 0.177 0.815 0.44 -8 0.298 P57727 V53I Polymorphism NA 0.318 0.97 -12 0.224 P57727 A426T Polymorphism 0.436 0.801 0.03 47 0.730 P57737 A174V Polymorphism 0.321 0.424 1.00 41 0.391 P57737 A403T Polymorphism 0.408 0.079 0.57 -9 0.070 P57737 L257S Polymorphism 0.969 0.792 0.01 41 0.909 P57768 P98L Polymorphism 0.666 0.210 0.01 26 0.220 P57773 V497I Polymorphism NA 0.148 NA 16 0.131 P57789 A512T Polymorphism 0.180 0.144 NA 36 0.145 P57796 R124C Disease NA 0.900 0.00 44 0.874 P58005 R71C Polymorphism 0.695 0.913 0.00 57 0.923 P58005 I227T Polymorphism 0.136 0.424 0.12 -28 0.224 P58012 A66V Disease 0.947 0.889 0.08 45 0.895 P58012 E69K Disease 0.718 0.412 0.20 10 0.451 P58012 F90S Disease 0.993 0.656 0.00 47 0.888 P58012 I80T Disease 0.993 0.861 0.00 51 0.844 P58012 I84N Disease 0.998 0.884 0.00 38 0.919 P58012 I84S Disease 0.996 0.811 0.00 40 0.913 P58012 M65V Disease 0.944 0.838 0.01 49 0.907 P58012 S58L Disease NA 0.819 0.00 46 0.854 P58012 W98G Disease 0.998 0.886 0.00 75 0.835 P58012 A179G Polymorphism 0.612 0.216 0.34 -9 0.156 P58012 H104R Disease 0.998 0.892 0.00 69 0.845 P58012 I102T Disease 0.992 0.787 0.00 52 0.877 P58012 K193R Disease 0.609 0.334 0.69 28 0.404 P58012 L106F Disease 0.997 0.777 0.00 68 0.866 P58012 L106P Disease 0.999 0.881 0.00 62 0.867 P58012 N105S Disease 0.940 0.882 0.07 48 0.857 P58012 N109K Disease 0.917 0.901 0.00 69 0.803 P58012 P285S Polymorphism 0.534 0.155 0.03 47 0.177 P58012 R103C Disease 0.999 0.888 0.00 77 0.824 P58012 S101R Disease 0.998 0.914 0.00 73 0.866 P58012 S217F Disease 0.592 0.478 0.00 50 0.634 P58012 Y215C Disease 0.952 0.308 0.15 61 0.694 P58012 Y258N Disease 0.455 0.292 0.07 52 0.447 P58173 V117I Polymorphism 0.432 0.451 0.06 -8 0.338 P58181 F20V Polymorphism 0.097 0.416 0.49 0 0.142 P58182 L56P Polymorphism 0.383 0.269 1.00 0 0.083 P58182 V47F Polymorphism 0.676 0.930 0.01 50 0.923 P58182 F113L Polymorphism 0.424 0.266 1.00 -12 0.088 P58182 L120R Polymorphism 0.442 0.251 1.00 -23 0.087 P58182 S121C Polymorphism 0.290 0.669 0.00 13 0.414 P58182 V132G Polymorphism 0.376 0.492 0.03 50 0.733 P58215 I615F Polymorphism 0.407 0.558 0.03 -4 0.608 P58294 V67I Polymorphism 0.067 0.172 0.11 6 0.145 P58304 R200P Disease 0.789 0.939 0.00 85 0.910 P58304 R200Q Disease 0.611 0.902 0.00 77 0.918 P58304 R227W Disease 0.920 0.921 0.01 55 0.941 P58335 L45P Disease 0.826 0.946 0.00 41 0.867 P58335 C218R Disease 0.810 0.925 0.06 70 0.884 P58335 G105D Disease 0.433 0.916 0.04 46 0.844 P58335 I189T Disease 0.588 0.901 0.00 53 0.883 P58335 L329R Disease 0.743 0.873 0.01 24 0.813 P58335 Y381C Disease 0.716 0.892 0.00 66 0.749 P58340 P226T Polymorphism 0.471 0.098 0.14 3 0.098 P58397 R1000Q Polymorphism NA 0.229 0.39 26 0.372 P58397 T1495I Polymorphism 0.379 0.270 0.27 21 0.375 P58397 W1177R Polymorphism NA 0.154 0.27 59 0.168 P58418 K7I Polymorphism NA 0.271 0.08 38 0.397 P58418 C40G Disease NA 0.703 0.02 35 0.738 P58418 N48K Disease NA 0.466 0.13 47 0.609 P58418 L150P Disease NA 0.875 0.01 46 0.820 P58418 M120K Disease NA 0.210 0.04 22 0.343 P58418 S105P Disease NA 0.473 0.16 25 0.549 P58499 V14M Polymorphism 0.237 0.124 0.11 -24 0.120 P58511 K51R Polymorphism NA 0.018 0.00 -30 0.050 P58753 R13W Polymorphism NA 0.125 0.01 45 0.173 P58753 S55N Polymorphism 0.316 0.033 0.01 8 0.076 P59020 G23V Polymorphism NA 0.340 NA 21 0.072 P59020 R76L Polymorphism NA 0.162 NA 15 0.033 P59025 A212G Polymorphism 0.323 0.091 0.05 14 0.101 P59025 Q229E Polymorphism 0.063 0.037 0.69 25 0.037 P59044 M163L Polymorphism 0.400 0.103 0.46 -18 0.132 P59044 Y361F Polymorphism 0.264 0.538 0.78 6 0.325 P59045 P438L Polymorphism NA 0.134 0.12 -9 0.258 P59046 G39V Polymorphism NA 0.461 0.30 22 0.373 P59046 F402L Polymorphism 0.351 0.314 0.81 9 0.213 P59047 H584P Polymorphism 0.858 0.926 0.00 68 0.951 P59047 M459I Polymorphism 0.390 0.260 0.34 -1 0.364 P59047 M912T Polymorphism 0.164 0.202 0.23 30 0.169 P59047 R761L Polymorphism 0.077 0.433 0.31 52 0.284 P59047 A1097T Polymorphism 0.135 0.712 0.58 -7 0.209 P59047 R1195Q Polymorphism NA 0.203 0.44 30 0.200 P59047 S1108C Polymorphism 0.620 0.751 0.08 26 0.785 P59047 V1181I Polymorphism 0.084 0.183 0.24 -6 0.087 P59092 C49Y Polymorphism NA 0.696 NA 25 0.445 P59095 E159K Polymorphism 0.100 0.092 0.87 -4 0.084 P59510 K876M Polymorphism 0.684 0.055 0.16 -14 0.245 P59510 R1000H Polymorphism 0.594 0.188 0.18 -14 0.447 P59510 S1273F Polymorphism 0.638 0.217 0.15 28 0.529 P59533 A49P Polymorphism NA 0.570 0.13 -17 0.417 P59533 A262V Polymorphism NA 0.321 0.23 16 0.345 P59534 K197E Polymorphism NA 0.428 0.30 5 0.276 P59535 V23L Polymorphism NA 0.341 0.63 -9 0.246 P59535 S187Y Polymorphism NA 0.527 0.85 32 0.433 P59536 P127L Polymorphism NA 0.595 0.28 -15 0.414 P59538 R35W Polymorphism NA 0.206 1.00 -42 0.051 P59538 A227V Polymorphism NA 0.805 0.12 27 0.629 P59538 Q217E Polymorphism NA 0.405 0.03 33 0.451 P59538 V240I Polymorphism NA 0.059 1.00 -39 0.021 P59542 R299C Polymorphism NA 0.222 0.00 8 0.227 P59543 F252S Polymorphism NA 0.464 0.58 -4 0.272 P59543 H148N Polymorphism NA 0.340 1.00 -12 0.191 P59543 R255L Polymorphism NA 0.290 0.66 -31 0.184 P59817 K71N Polymorphism NA 0.055 0.14 12 0.053 P59817 G249A Polymorphism NA 0.170 0.01 35 0.320 P59817 L276F Polymorphism NA 0.470 0.04 38 0.619 P59817 N136S Polymorphism NA 0.061 0.43 6 0.097 P59817 N246S Polymorphism NA 0.249 0.31 18 0.262 P59826 P449S Polymorphism 0.441 0.840 0.09 42 0.808 P59826 T290M Polymorphism 0.337 0.205 0.10 37 0.311 P59827 G167W Polymorphism NA 0.419 NA 43 0.414 P59827 G206W Polymorphism 0.681 0.350 0.01 41 0.533 P59827 N320T Polymorphism 0.224 0.371 0.48 14 0.346 P59894 V83M Polymorphism NA 0.051 NA 23 0.056 P59901 P27L Polymorphism NA 0.824 0.00 10 0.567 P59923 Y428C Polymorphism 0.740 0.636 0.06 17 0.828 P59942 E42K Polymorphism NA 0.045 NA 29 0.072 P59991 A16T Polymorphism NA 0.065 0.37 10 0.030 P59991 A16V Polymorphism NA 0.054 0.26 3 0.019 P59991 S29C Polymorphism NA 0.206 0.17 -3 0.161 P59991 A116V Polymorphism NA 0.061 0.54 -9 0.021 P60014 T72P Polymorphism 0.487 0.234 1.00 -12 0.126 P60014 T86S Polymorphism 0.353 0.268 0.81 -3 0.256 P60014 V20D Polymorphism 0.483 0.272 1.00 8 0.120 P60014 C126S Polymorphism 0.392 0.696 0.28 28 0.569 P60014 Q129P Polymorphism 0.311 0.595 0.30 13 0.440 P60014 V158M Polymorphism 0.385 0.603 0.21 1 0.536 P60022 V38I Polymorphism 0.083 0.063 0.08 12 0.037 P60153 F148S Polymorphism NA 0.183 1.00 0 0.035 P60201 A39T Disease 0.769 0.828 0.00 50 0.895 P60201 A76P Disease 0.882 0.976 0.00 51 0.853 P60201 C33Y Disease 0.973 0.978 0.00 60 0.970 P60201 C35R Disease 0.703 0.969 0.00 68 0.939 P60201 C35Y Disease 0.759 0.971 0.00 60 0.938 P60201 F32L Disease 0.824 0.913 0.00 46 0.886 P60201 F32V Disease 0.913 0.919 0.00 54 0.951 P60201 F51S Disease 0.933 0.958 0.00 39 0.916 P60201 G74R Disease 0.947 0.988 0.00 53 0.948 P60201 L31P Disease 0.943 0.965 0.00 31 0.915 P60201 L46R Disease 0.665 0.868 0.00 43 0.844 P60201 P15L Disease 0.957 0.916 0.00 37 0.947 P60201 T43I Disease 0.469 0.912 0.01 44 0.772 P60201 Y50C Disease 0.808 0.929 0.01 47 0.876 P60201 Y60C Disease 0.808 0.368 0.16 19 0.586 P60201 A242P Disease 0.558 0.734 0.05 35 0.776 P60201 A243E Disease 0.918 0.941 0.01 44 0.903 P60201 A243V Disease 0.863 0.780 0.01 29 0.840 P60201 A247T Disease 0.756 0.866 0.00 28 0.840 P60201 A248E Disease 0.501 0.587 0.01 29 0.554 P60201 A249P Disease 0.558 0.913 0.02 34 0.727 P60201 C169R Disease 0.703 0.812 0.02 47 0.837 P60201 C220Y Disease 0.770 0.964 0.00 60 0.937 P60201 C228Y Disease 0.959 0.980 0.00 57 0.968 P60201 D203E Disease 0.800 0.899 0.00 54 0.934 P60201 D203G Disease 0.888 0.940 0.00 56 0.953 P60201 D203H Disease 0.949 0.860 0.00 69 0.950 P60201 D203N Disease 0.869 0.893 0.00 56 0.944 P60201 D203V Disease 0.958 0.931 0.00 58 0.968 P60201 F237S Disease 0.570 0.799 0.00 32 0.796 P60201 G217S Disease 0.323 0.804 0.05 38 0.651 P60201 G221C Disease 0.779 0.935 0.00 46 0.738 P60201 G246A Disease 0.846 0.906 0.00 31 0.877 P60201 G246E Disease 0.924 0.948 0.00 56 0.854 P60201 H130Y Disease 0.225 0.105 0.07 49 0.042 P60201 H140Y Disease 0.251 0.161 0.09 53 0.168 P60201 I187T Disease 0.419 0.653 0.02 28 0.464 P60201 K151N Disease 0.395 0.544 0.20 12 0.626 P60201 L210H Disease 0.763 0.632 0.00 56 0.853 P60201 L224P Disease 0.736 0.950 0.00 55 0.930 P60201 L225P Disease 0.736 0.720 0.30 18 0.767 P60201 L239P Disease 0.940 0.947 0.00 52 0.946 P60201 P173S Disease 0.900 0.918 0.00 41 0.902 P60201 P211L Disease 0.332 0.880 0.01 38 0.709 P60201 P216A Disease 0.503 0.667 0.04 36 0.581 P60201 P216L Disease 0.667 0.875 0.01 32 0.802 P60201 P216S Disease 0.545 0.736 0.02 34 0.773 P60201 Q234P Disease 0.587 0.693 0.28 -6 0.752 P60201 R137W Disease 0.564 0.522 0.05 44 0.704 P60201 R205G Disease 0.891 0.927 0.00 56 0.952 P60201 S170F Disease 0.674 0.930 0.00 42 0.849 P60201 S170P Disease 0.558 0.952 0.01 59 0.920 P60201 S226P Disease 0.378 0.546 0.14 16 0.657 P60201 S253F Disease 0.529 0.596 0.00 19 0.700 P60201 T116K Disease 0.369 0.529 0.02 59 0.754 P60201 T156I Disease 0.381 0.954 0.00 38 0.734 P60201 T182P Disease 0.433 0.696 0.02 47 0.772 P60201 T183N Disease 0.526 0.844 0.02 49 0.861 P60201 V162E Disease 0.552 0.624 0.06 29 0.721 P60201 V166E Disease 0.555 0.962 0.00 47 0.847 P60201 V172A Disease 0.370 0.446 0.01 18 0.432 P60201 V209D Disease 0.678 0.693 0.00 48 0.835 P60201 V219F Disease 0.348 0.399 0.01 43 0.313 P60201 W163R Disease 0.967 0.989 0.00 52 0.958 P60201 W181C Disease 0.847 0.968 0.01 57 0.947 P60201 W212R Disease 0.509 0.964 0.02 58 0.922 P60201 Y175C Disease 0.808 0.897 0.00 44 0.865 P60201 Y207C Disease 0.817 0.934 0.00 60 0.944 P60331 P39L Polymorphism 0.957 0.816 0.13 41 0.904 P60331 P280L Polymorphism NA 0.605 0.62 7 0.459 P60331 V101M Polymorphism 0.661 0.459 0.13 19 0.603 P60368 A117P Polymorphism 0.641 0.471 1.00 33 0.570 P60370 D20N Polymorphism 0.312 0.731 0.51 36 0.541 P60370 F183C Polymorphism 0.506 0.180 0.68 -12 0.077 P60371 V159I Polymorphism NA 0.180 0.21 -4 0.220 P60372 I159V Polymorphism NA 0.116 1.00 4 0.104 P60409 M116V Polymorphism NA 0.132 0.54 -24 0.095 P60409 S290T Polymorphism 0.295 0.627 0.73 24 0.430 P60409 T325A Polymorphism NA 0.214 0.81 -3 0.178 P60409 Y129C Polymorphism NA 0.193 1.00 0 0.126 P60410 H26R Polymorphism NA 0.220 0.37 39 0.103 P60412 S130F Polymorphism 0.776 0.920 0.01 48 0.898 P60413 G226S Polymorphism NA 0.147 0.34 -7 0.126 P60484 A34D Disease 0.850 0.957 0.01 57 0.941 P60484 C71Y Disease 0.989 0.970 0.00 48 0.927 P60484 H93R Disease 0.835 0.716 0.89 38 0.799 P60484 H93Y Disease 0.819 0.930 0.14 28 0.848 P60484 I67R Disease 0.676 0.875 0.00 48 0.887 P60484 L70P Disease 0.920 0.953 0.00 38 0.898 P60484 M35R Disease 0.853 0.969 0.01 67 0.941 P60484 R47G Disease 0.842 0.936 0.02 51 0.924 P60484 Y68H Disease 0.240 0.554 0.00 27 0.685 P60484 A121G Disease 0.418 0.770 0.03 3 0.650 P60484 C105F Disease 0.722 0.909 0.00 11 0.862 P60484 C105Y Disease 0.769 0.886 0.00 31 0.854 P60484 C124R Disease 0.921 0.948 0.02 74 0.940 P60484 C124S Disease 0.816 0.883 0.09 53 0.851 P60484 C136Y Disease 0.273 0.916 0.02 32 0.722 P60484 D107Y Disease 0.773 0.532 0.06 9 0.759 P60484 D252G Disease 0.772 0.919 0.00 49 0.902 P60484 D331G Disease 0.464 0.590 0.07 44 0.601 P60484 F241S Disease 0.561 0.731 0.45 -19 0.595 P60484 F341V Disease 0.151 0.570 0.50 44 0.620 P60484 F347L Disease 0.774 0.424 0.04 15 0.484 P60484 G129E Disease 0.636 0.919 0.02 58 0.752 P60484 G165E Disease 0.893 0.842 0.10 57 0.931 P60484 G165V Disease 0.911 0.837 0.67 40 0.828 P60484 H123R Disease 0.835 0.884 0.01 63 0.938 P60484 H123Y Disease 0.819 0.946 0.13 50 0.744 P60484 I135V Disease 0.165 0.432 1.00 -46 0.230 P60484 K289E Disease 0.015 0.227 0.14 -21 0.158 P60484 K342N Disease 0.411 0.374 0.26 -18 0.404 P60484 L112P Disease 0.763 0.946 0.00 29 0.863 P60484 M134L Disease 0.446 0.829 0.66 -25 0.494 P60484 P246L Disease 0.896 0.464 0.10 -10 0.619 P60484 R130L Disease 0.988 0.876 0.11 62 0.954 P60484 R130Q Disease 0.982 0.877 0.24 55 0.940 P60484 S170R Disease 0.985 0.921 0.00 29 0.941 P60484 V290L Polymorphism 0.013 0.130 0.56 -55 0.118 P60484 V343E Disease 0.918 0.610 0.01 46 0.784 P60484 Y155C Disease 0.815 0.629 0.00 2 0.774 P60520 V51A Polymorphism 0.873 0.863 0.00 -1 0.804 P60709 P243L Polymorphism 0.761 0.938 0.00 12 0.877 P60709 R183W Disease 0.889 0.889 0.00 -8 0.858 P60852 T158I Polymorphism 0.059 0.151 0.83 38 0.076 P60891 D52H Disease 0.540 0.881 0.13 26 0.536 P60891 E43D Disease 0.537 0.380 0.31 -60 0.509 P60891 A190V Disease 0.500 0.839 0.06 -20 0.503 P60891 D183H Disease 0.771 0.647 0.02 -12 0.719 P60891 H193Q Disease 0.365 0.585 0.01 17 0.674 P60891 L129I Disease 0.551 0.738 0.01 -18 0.587 P60891 L152P Disease 0.877 0.824 0.28 23 0.844 P60891 M115T Disease 0.868 0.800 0.00 24 0.836 P60891 N114S Disease 0.408 0.784 0.00 -21 0.536 P60891 Q133P Disease 0.898 0.909 0.00 66 0.925 P60900 A233S Polymorphism 0.090 0.598 0.01 -83 0.093 P61106 A4T Polymorphism NA 0.702 0.36 -33 0.518 P61278 N61T Polymorphism 0.151 0.047 0.67 -71 0.018 P61457 C82R Disease 0.718 0.604 0.02 38 0.783 P61457 E97K Disease 0.667 0.609 0.01 31 0.782 P61457 R88Q Disease 0.219 0.414 0.34 20 0.324 P61626 D85H Disease 0.764 0.547 0.01 14 0.778 P61626 I74T Disease 0.688 0.825 0.00 48 0.883 P61626 T88N Polymorphism 0.619 0.550 0.01 5 0.531 P61758 M123V Polymorphism 0.567 0.076 1.00 -15 0.028 P61764 V84D Disease 0.921 0.819 0.00 24 0.898 P61764 C180Y Disease 0.969 0.887 0.26 38 0.899 P61764 G544D Disease 0.998 0.977 0.00 70 0.958 P61764 M443R Disease 0.111 0.850 0.02 36 0.259 P61769 A11P Disease NA 0.266 0.23 0 0.390 P61812 R91H Polymorphism NA 0.267 0.15 -41 0.358 P61812 V207L Polymorphism 0.650 0.688 1.00 -45 0.569 P61916 C47F Disease 0.943 0.868 0.00 68 0.955 P61916 C93F Disease 0.586 0.863 0.00 72 0.901 P61916 C99R Disease 0.975 0.962 0.00 78 0.963 P61916 S67P Disease 0.813 0.623 0.06 51 0.881 P61916 V30M Disease 0.515 0.038 0.25 10 0.180 P61916 V39M Disease 0.825 0.206 0.01 56 0.448 P61916 P120S Disease 0.684 0.833 0.00 49 0.883 P61956 D16N Polymorphism 0.265 0.389 0.19 -31 0.285 P62068 A81V Polymorphism 0.286 0.600 0.11 13 0.411 P62158 M73T Polymorphism 0.596 0.653 0.06 37 0.795 P62241 R110G Polymorphism 0.606 0.923 0.01 26 0.872 P62424 A24V Polymorphism 0.055 0.217 0.64 -9 0.175 P62508 T50M Polymorphism NA 0.085 0.23 24 0.087 P62736 H373P Polymorphism 0.694 0.910 0.00 27 0.877 P62736 N117T Disease 0.658 0.771 0.05 9 0.734 P62736 R118Q Disease 0.672 0.817 0.00 20 0.794 P62736 R149C Disease 0.730 0.952 0.09 -16 0.690 P62736 R258C Disease 0.856 0.873 0.01 17 0.824 P62736 R258H Disease 0.741 0.696 0.03 20 0.774 P62736 R292G Disease 0.904 0.835 0.00 1 0.883 P62736 T353N Disease 0.531 0.782 0.04 -2 0.544 P62736 V154A Disease 0.909 0.741 0.00 10 0.822 P62736 Y135H Disease 0.733 0.814 0.09 -14 0.683 P62753 K221R Polymorphism 0.106 0.166 0.51 -12 0.138 P62760 K172R Polymorphism 0.209 0.203 0.24 -59 0.263 P62807 G27S Polymorphism 0.169 0.493 0.31 -20 0.267 P62861 V19M Polymorphism 0.646 0.667 0.05 3 0.745 P62906 T154P Polymorphism 0.598 0.807 0.02 15 0.831 P62913 L20H Disease 0.875 0.823 0.00 25 0.868 P62917 I98V Polymorphism 0.090 0.198 1.00 -54 0.147 P63000 A59T Polymorphism 0.923 0.867 0.01 41 0.872 P63000 D63G Polymorphism 0.766 0.513 0.03 26 0.718 P63000 F28L Polymorphism 0.720 0.912 0.00 36 0.845 P63000 N26D Polymorphism 0.172 0.360 0.66 -34 0.227 P63000 V93G Polymorphism 0.751 0.812 0.00 7 0.817 P63000 V93I Polymorphism 0.175 0.290 0.50 -58 0.226 P63000 K130R Polymorphism 0.101 0.108 0.55 -67 0.116 P63000 K133E Polymorphism 0.209 0.329 0.29 -43 0.289 P63000 P180S Polymorphism 0.103 0.582 0.52 -55 0.124 P63000 T108I Polymorphism 0.135 0.229 0.50 -45 0.225 P63000 T135I Polymorphism 0.198 0.206 0.11 -23 0.232 P63000 V182E Polymorphism 0.086 0.485 0.98 -43 0.114 P63092 L99P Disease 0.694 0.853 0.08 30 0.859 P63092 A366S Disease 0.962 0.889 0.00 48 0.917 P63092 D156N Disease 0.674 0.920 0.00 34 0.848 P63092 E259V Disease 0.997 0.846 0.00 56 0.947 P63092 F246S Disease 0.539 0.923 0.00 42 0.863 P63092 K338N Disease 0.648 0.418 0.36 -2 0.582 P63092 P115L Disease 0.841 0.251 0.96 8 0.581 P63092 R165C Disease 0.927 0.920 0.00 42 0.894 P63092 R201C Disease 0.997 0.917 0.00 47 0.912 P63092 R201G Disease 0.991 0.907 0.00 52 0.948 P63092 R201H Disease 0.995 0.911 0.00 35 0.932 P63092 R201S Disease 0.994 0.912 0.00 42 0.939 P63092 R231H Disease 0.817 0.860 0.00 69 0.925 P63092 R258W Disease 0.922 0.786 0.18 -8 0.794 P63092 R280G Disease 0.764 0.703 0.05 9 0.833 P63092 R280K Disease 0.479 0.657 1.00 -12 0.381 P63092 R380L Polymorphism NA 0.543 0.16 14 0.591 P63092 R385H Disease NA 0.546 0.03 -11 0.489 P63092 S250R Disease 0.474 0.908 0.00 46 0.883 P63092 T242I Disease 0.677 0.837 0.00 27 0.839 P63092 V159M Disease 0.696 0.879 0.03 -8 0.748 P63092 W281R Disease 0.635 0.927 0.00 41 0.872 P63252 D71V Disease 0.994 0.942 0.00 50 0.951 P63252 R67W Disease 0.987 0.956 0.07 37 0.935 P63252 D172N Disease 0.354 0.705 0.92 -31 0.404 P63252 G300V Disease 0.986 0.829 0.01 51 0.944 P63252 N216H Disease 0.824 0.746 0.00 40 0.863 P63252 P186L Disease 0.958 0.794 0.00 32 0.897 P63252 R218W Disease 0.996 0.958 0.00 60 0.957 P63252 V302M Disease 0.924 0.832 0.01 18 0.846 P63261 T89I Disease 0.315 0.500 0.32 -53 0.379 P63261 K118M Disease 0.671 0.798 0.01 -11 0.803 P63261 P243L Polymorphism 0.761 0.938 0.00 14 0.879 P63261 P264L Disease 0.953 0.876 0.00 28 0.889 P63261 P332A Disease 0.378 0.462 0.08 5 0.430 P63261 T160I Polymorphism 0.802 0.827 0.00 24 0.858 P63261 T278I Disease 0.383 0.442 0.32 -59 0.286 P63261 V370A Disease 0.638 0.426 0.02 16 0.566 P63313 M7R Polymorphism 0.626 0.196 0.00 5 0.397 P63316 G159R Disease 0.657 0.787 0.01 26 0.783 P68032 H90Y Disease 0.300 0.600 0.38 -33 0.328 P68032 R97C Disease 0.860 0.871 0.01 -19 0.835 P68032 A297S Disease 0.348 0.198 0.57 -79 0.199 P68032 A333P Disease 0.651 0.831 0.00 3 0.850 P68032 E101K Disease 0.463 0.641 0.05 -17 0.490 P68032 E363G Disease 0.854 0.724 0.00 31 0.848 P68032 M307L Disease 0.270 0.859 0.27 -39 0.381 P68032 P166A Disease 0.810 0.892 0.00 23 0.796 P68032 R314H Disease 0.929 0.758 0.00 45 0.904 P68032 Y168C Disease 0.745 0.941 0.00 21 0.812 P68133 G17R Disease NA 0.925 0.00 23 0.859 P68133 H42Y Disease 0.426 0.423 0.31 -45 0.281 P68133 L96P Disease 0.925 0.905 0.00 30 0.901 P68133 D288G Disease 0.798 0.827 0.00 22 0.806 P68133 D294V Disease 0.595 0.835 0.01 -7 0.569 P68133 E261V Disease 0.882 0.865 0.00 51 0.912 P68133 G184D Disease 0.976 0.877 0.00 60 0.933 P68133 G270C Disease 0.954 0.914 0.00 15 0.915 P68133 I138M Disease 0.643 0.543 0.10 -59 0.440 P68133 I359L Disease 0.544 0.464 0.05 -45 0.587 P68133 L223P Disease 0.409 0.915 0.14 -6 0.520 P68133 M134V Disease 0.370 0.615 0.21 -36 0.447 P68133 M271R Disease 0.401 0.797 0.40 -20 0.458 P68133 N117S Disease 0.540 0.689 0.00 -21 0.544 P68133 N282K Disease 0.421 0.532 0.21 -49 0.415 P68133 P334S Disease 0.368 0.604 0.22 -50 0.411 P68133 Q265L Disease 0.700 0.704 0.05 8 0.759 P68133 R185C Disease 0.863 0.888 0.04 -6 0.790 P68133 R185G Disease 0.681 0.816 0.05 14 0.635 P68133 R258H Disease 0.741 0.696 0.03 18 0.775 P68133 V165L Disease 0.494 0.868 0.00 6 0.696 P68133 V372F Disease 0.700 0.763 0.03 32 0.856 P68871 H3L Polymorphism NA 0.570 0.02 -15 0.452 P68871 V12D Polymorphism 0.984 0.822 0.00 52 0.940 P69891 I76T Polymorphism 0.530 0.401 0.00 1 0.528 P69892 I76T Polymorphism 0.530 0.402 0.00 -35 0.518 P69905 K61N Polymorphism 0.368 0.748 0.00 11 0.642 P69905 L92P Polymorphism 0.986 0.934 0.00 46 0.944 P69905 N69K Polymorphism 0.083 0.415 0.38 -21 0.140 P69905 P45L Polymorphism 0.491 0.482 0.00 4 0.494 P69905 S103R Polymorphism 0.474 0.636 0.02 57 0.766 P78312 M192V Polymorphism 0.089 0.210 NA 0 0.220 P78314 G420E Disease 0.679 0.324 0.33 47 0.420 P78314 G420R Disease 0.751 0.456 0.87 49 0.547 P78314 P418H Disease 0.836 0.281 0.00 39 0.510 P78314 P418L Disease 0.709 0.220 0.00 27 0.465 P78314 P418R Disease 0.726 0.296 0.00 43 0.512 P78314 R415P Disease 0.717 0.423 0.36 33 0.405 P78314 R415Q Disease 0.514 0.184 0.40 32 0.273 P78324 A20P Polymorphism 0.460 0.341 0.23 -51 0.206 P78324 D40E Polymorphism 0.162 0.035 1.00 -57 0.023 P78324 E77K Polymorphism 0.256 0.706 0.76 20 0.440 P78324 I61N Polymorphism 0.502 0.705 0.60 -1 0.498 P78324 N81H Polymorphism 0.545 0.352 0.24 33 0.509 P78324 R125Q Polymorphism 0.155 0.200 0.37 13 0.204 P78325 G101R Polymorphism 0.152 0.230 0.37 42 0.300 P78330 D32N Disease 0.605 0.852 0.01 42 0.652 P78330 M52T Disease 0.743 0.943 0.00 59 0.936 P78332 N721T Polymorphism 0.399 0.141 0.03 28 0.164 P78334 S102A Polymorphism 0.059 0.155 0.04 8 0.181 P78337 E130K Disease 0.999 0.920 0.00 57 0.948 P78337 G299A Polymorphism NA 0.145 0.20 -24 0.103 P78345 E88D Polymorphism NA 0.104 0.02 8 0.091 P78347 L174V Polymorphism 0.582 0.821 0.00 43 0.834 P78362 P43L Polymorphism 0.374 0.191 0.46 -2 0.210 P78362 L615I Polymorphism NA 0.250 0.28 19 0.365 P78362 P515T Polymorphism NA 0.386 0.05 42 0.482 P78362 S486F Polymorphism NA 0.163 0.40 23 0.163 P78362 T426P Polymorphism NA 0.212 0.19 51 0.353 P78363 A60E Disease 0.220 0.627 0.04 46 0.666 P78363 A60T Disease 0.222 0.562 0.06 34 0.668 P78363 A60V Disease 0.262 0.585 0.06 30 0.671 P78363 C54Y Disease 0.539 0.860 0.01 61 0.903 P78363 C75G Disease NA 0.907 0.54 47 0.735 P78363 G65E Disease 0.920 0.816 0.00 66 0.925 P78363 G72R Disease NA 0.813 0.02 54 0.873 P78363 L11P Disease 0.957 0.917 0.00 49 0.957 P78363 N58K Disease 0.248 0.784 0.27 32 0.609 P78363 N96D Disease NA 0.556 0.61 46 0.606 P78363 N96H Disease NA 0.519 0.19 57 0.732 P78363 P68L Disease 0.799 0.726 0.00 36 0.858 P78363 P68R Disease 0.810 0.836 0.00 54 0.837 P78363 R18W Disease 0.943 0.865 0.00 47 0.917 P78363 R24H Disease 0.456 0.232 0.16 30 0.387 P78363 V77E Disease NA 0.442 0.12 49 0.611 P78363 A192T Disease NA 0.151 0.36 -30 0.103 P78363 A407V Disease NA 0.152 1.00 -40 0.080 P78363 A549P Disease NA 0.972 0.02 20 0.829 P78363 A854T Disease 0.110 0.218 0.47 -40 0.198 P78363 C230S Disease NA 0.928 0.00 16 0.699 P78363 C764Y Disease 0.958 0.756 0.01 40 0.841 P78363 D249G Disease NA 0.769 0.07 21 0.680 P78363 D523E Disease 0.144 0.816 0.03 -8 0.338 P78363 D645N Disease 0.937 0.824 0.00 20 0.834 P78363 D846H Polymorphism 0.925 0.708 0.00 22 0.844 P78363 E328V Disease NA 0.539 0.25 27 0.722 P78363 E471K Disease NA 0.131 0.71 8 0.204 P78363 F525C Disease 0.618 0.901 0.01 39 0.862 P78363 F608I Disease 0.745 0.942 0.02 38 0.881 P78363 F873L Disease 0.598 0.847 0.04 54 0.654 P78363 G550R Disease NA 0.921 0.11 31 0.836 P78363 G607R Disease 0.941 0.970 0.01 60 0.906 P78363 G607W Disease 0.981 0.965 0.00 53 0.953 P78363 G818E Disease 0.867 0.906 0.00 70 0.894 P78363 G851D Disease 0.923 0.510 0.35 13 0.728 P78363 G863A Disease 0.956 0.582 0.00 21 0.810 P78363 G978C Disease 0.999 0.807 0.00 51 0.964 P78363 G991R Disease 0.983 0.908 0.00 73 0.950 P78363 H914R Polymorphism 0.048 0.211 0.41 14 0.127 P78363 I156V Disease NA 0.141 1.00 3 0.116 P78363 I824T Disease 0.374 0.335 0.03 11 0.400 P78363 L244P Disease NA 0.858 0.01 54 0.884 P78363 L541P Disease 0.905 0.979 0.03 38 0.911 P78363 L686S Disease 0.547 0.316 0.00 29 0.600 P78363 L797P Disease 0.905 0.833 0.01 58 0.917 P78363 N247S Disease NA 0.607 0.43 -3 0.450 P78363 N380K Disease NA 0.411 0.53 40 0.549 P78363 N965S Disease 0.989 0.896 0.00 60 0.930 P78363 P309R Disease NA 0.318 0.19 22 0.373 P78363 Q190H Disease NA 0.273 0.03 22 0.384 P78363 Q635K Disease 0.765 0.547 0.00 44 0.729 P78363 Q636H Disease 0.851 0.311 0.11 11 0.595 P78363 Q957R Disease 0.535 0.791 0.15 39 0.878 P78363 R212C Disease NA 0.671 0.03 45 0.728 P78363 R212H Polymorphism NA 0.283 0.11 26 0.354 P78363 R220C Disease NA 0.409 0.01 44 0.596 P78363 R333W Disease NA 0.706 0.19 47 0.780 P78363 R537C Disease 0.733 0.542 0.02 22 0.754 P78363 R572P Disease 0.917 0.968 0.00 61 0.928 P78363 R572Q Disease 0.833 0.905 0.00 56 0.930 P78363 R602Q Disease 0.747 0.331 0.35 5 0.572 P78363 R602W Disease 0.954 0.688 0.03 14 0.679 P78363 R653C Disease 0.937 0.744 0.17 10 0.799 P78363 R943Q Polymorphism 0.226 0.600 0.33 0 0.221 P78363 R943W Disease 0.769 0.899 0.00 44 0.904 P78363 S100P Disease NA 0.771 0.02 35 0.653 P78363 S206R Disease NA 0.229 0.53 44 0.285 P78363 S336C Disease NA 0.682 0.01 43 0.732 P78363 S445R Disease NA 0.665 0.12 42 0.637 P78363 S752I Polymorphism 0.906 0.740 0.00 52 0.915 P78363 S765N Disease 0.343 0.475 0.07 9 0.542 P78363 S765R Disease 0.410 0.635 0.02 36 0.783 P78363 S974P Disease 0.871 0.727 0.00 52 0.910 P78363 T300N Disease NA 0.123 0.18 -27 0.127 P78363 T716M Disease 0.357 0.359 0.06 -44 0.312 P78363 T897I Disease 0.409 0.107 0.14 15 0.255 P78363 T901A Polymorphism 0.169 0.087 0.82 6 0.133 P78363 T959I Disease 0.784 0.695 0.06 32 0.780 P78363 T971N Disease 0.992 0.883 0.00 57 0.965 P78363 T972N Disease 0.940 0.845 0.03 44 0.908 P78363 V643G Polymorphism 0.808 0.623 0.01 26 0.733 P78363 V643M Disease 0.760 0.316 0.19 -10 0.572 P78363 V767D Disease 0.717 0.597 0.00 38 0.796 P78363 V849A Disease 0.192 0.379 0.04 3 0.324 P78363 V931M Disease 0.385 0.543 0.03 7 0.366 P78363 V935A Disease 0.516 0.197 0.34 -10 0.394 P78363 V989A Disease 0.243 0.546 0.01 38 0.469 P78363 W339G Disease NA 0.750 0.43 42 0.667 P78363 W821R Disease 0.991 0.833 0.00 71 0.940 P78363 Y340D Disease NA 0.805 0.19 32 0.687 P78363 A1038V Disease 0.090 0.294 0.97 -40 0.136 P78363 A1598D Disease 0.428 0.190 0.03 50 0.277 P78363 A1637T Polymorphism 0.513 0.687 0.30 28 0.559 P78363 A1794D Disease 0.474 0.500 0.16 25 0.759 P78363 A2216V Polymorphism 0.580 0.631 0.02 23 0.490 P78363 C1488F Disease NA 0.922 0.01 61 0.885 P78363 C1488R Disease NA 0.882 0.01 71 0.907 P78363 C1488Y Disease NA 0.928 0.01 45 0.830 P78363 C1490Y Disease NA 0.950 0.00 53 0.842 P78363 C2150R Disease 0.992 0.941 0.00 62 0.950 P78363 C2150Y Disease 0.995 0.911 0.00 52 0.948 P78363 D1204N Disease 0.590 0.197 0.22 0 0.420 P78363 D1532N Disease NA 0.570 0.30 41 0.522 P78363 D2177N Polymorphism NA 0.180 0.24 -24 0.218 P78363 E1022K Disease 0.838 0.873 0.00 74 0.935 P78363 E1036K Disease 0.091 0.260 0.74 -33 0.145 P78363 E1087D Disease 0.995 0.833 0.00 62 0.967 P78363 E1087K Disease 0.997 0.819 0.00 74 0.969 P78363 E1122K Disease 0.970 0.874 0.00 68 0.968 P78363 E1399K Disease 0.099 0.195 0.85 1 0.174 P78363 E1885K Disease 0.558 0.472 0.05 33 0.618 P78363 E2096K Disease 0.976 0.841 0.00 72 0.964 P78363 E2131K Disease 0.839 0.608 0.00 49 0.878 P78363 F1440S Disease 0.756 0.864 0.09 8 0.733 P78363 F1440V Disease 0.632 0.558 0.37 28 0.542 P78363 G1091E Disease 0.929 0.885 0.00 58 0.948 P78363 G1439D Disease 0.787 0.926 0.44 26 0.861 P78363 G1508C Disease NA 0.759 0.00 37 0.625 P78363 G1578R Disease NA 0.099 0.44 -16 0.071 P78363 G1748R Disease 0.510 0.701 0.13 3 0.529 P78363 G1886E Disease 0.931 0.610 0.00 47 0.839 P78363 G1961E Disease 0.928 0.605 0.00 35 0.881 P78363 G1975R Disease 0.997 0.939 0.00 78 0.975 P78363 G1977S Disease 0.997 0.908 0.00 68 0.977 P78363 G2146D Disease 0.997 0.952 0.00 75 0.974 P78363 H1406Y Disease 0.364 0.368 0.04 50 0.607 P78363 H1838Y Disease 0.777 0.312 0.05 56 0.611 P78363 H2128R Disease 0.994 0.800 0.00 71 0.965 P78363 I1562T Disease NA 0.367 0.02 44 0.481 P78363 K1031E Disease 0.975 0.753 0.00 52 0.948 P78363 K1148T Polymorphism 0.657 0.885 0.01 53 0.799 P78363 K2160R Disease 0.100 0.727 1.00 -23 0.334 P78363 L1014R Disease 0.989 0.868 0.00 70 0.964 P78363 L1201R Disease 0.799 0.641 0.54 40 0.718 P78363 L1250P Disease 0.720 0.926 0.00 55 0.917 P78363 L1388P Disease 0.909 0.906 0.01 46 0.894 P78363 L1430P Disease 0.467 0.951 0.01 52 0.840 P78363 L1525P Disease NA 0.939 0.00 56 0.911 P78363 L1631P Disease 0.844 0.906 0.01 62 0.927 P78363 L1729P Disease 0.681 0.745 0.01 42 0.834 P78363 L1763P Disease 0.903 0.712 0.05 33 0.825 P78363 L1940P Disease 0.720 0.808 0.01 30 0.873 P78363 L1970F Disease 0.920 0.702 0.00 51 0.923 P78363 L1971R Disease 0.997 0.889 0.00 68 0.974 P78363 L2027F Disease 0.876 0.837 0.02 60 0.858 P78363 L2035P Disease 0.722 0.820 0.02 56 0.906 P78363 L2060R Disease 0.930 0.884 0.00 70 0.946 P78363 L2229P Disease 0.848 0.936 0.03 22 0.867 P78363 L2241V Disease 0.941 0.833 0.00 49 0.898 P78363 M1733T Disease 0.236 0.424 0.09 2 0.195 P78363 N1799D Disease 0.791 0.870 0.00 40 0.882 P78363 N1805D Disease 0.653 0.744 0.29 11 0.778 P78363 P1314T Polymorphism NA 0.109 0.06 -11 0.232 P78363 P1380L Disease 0.987 0.908 0.00 32 0.926 P78363 P1486L Disease NA 0.622 0.06 30 0.510 P78363 P1776L Disease 0.941 0.678 0.01 -15 0.842 P78363 P1780A Disease 0.880 0.150 0.27 7 0.387 P78363 Q1513R Disease NA 0.322 0.37 37 0.336 P78363 Q1703K Disease 0.461 0.197 0.72 -6 0.195 P78363 R1055W Disease 0.691 0.420 0.01 36 0.630 P78363 R1097C Disease 0.990 0.849 0.00 63 0.961 P78363 R1108C Disease 0.939 0.662 0.00 15 0.818 P78363 R1108H Disease 0.858 0.681 0.01 27 0.797 P78363 R1108L Disease 0.821 0.708 0.02 28 0.799 P78363 R1129C Disease 0.965 0.871 0.00 58 0.944 P78363 R1129L Disease 0.898 0.880 0.01 56 0.936 P78363 R1300Q Disease NA 0.105 0.59 -5 0.121 P78363 R1443H Disease 0.777 0.541 0.20 36 0.693 P78363 R1517S Disease NA 0.108 0.44 5 0.079 P78363 R1640Q Disease 0.610 0.485 0.25 46 0.609 P78363 R1640W Disease 0.919 0.705 0.13 29 0.876 P78363 R1705L Disease 0.814 0.874 0.02 49 0.912 P78363 R1820P Disease 0.300 0.691 0.20 2 0.321 P78363 R1843W Disease 0.953 0.704 0.04 51 0.901 P78363 R1898H Disease 0.084 0.307 0.56 -29 0.206 P78363 R2030Q Disease 0.930 0.592 0.29 32 0.874 P78363 R2038W Disease 0.723 0.625 0.02 63 0.873 P78363 R2077G Disease 0.986 0.807 0.00 59 0.967 P78363 R2077W Disease 0.997 0.873 0.00 63 0.975 P78363 R2106C Disease 0.965 0.822 0.00 67 0.937 P78363 R2107C Disease 0.991 0.767 0.00 61 0.954 P78363 R2107H Disease 0.982 0.786 0.00 54 0.955 P78363 R2139W Disease 0.992 0.867 0.00 65 0.964 P78363 R2149L Disease 0.274 0.769 0.01 17 0.453 P78363 R2263L Disease 0.355 0.389 0.17 36 0.428 P78363 S1063P Disease 0.987 0.876 0.00 75 0.962 P78363 S1071L Disease 0.885 0.830 0.00 17 0.909 P78363 S1689P Disease 0.249 0.619 0.04 28 0.432 P78363 S1696N Disease 0.853 0.557 0.00 32 0.782 P78363 S1736P Disease 0.228 0.647 0.02 37 0.664 P78363 S2255I Polymorphism 0.212 0.327 0.17 -14 0.303 P78363 T1019A Disease 0.696 0.804 0.00 56 0.899 P78363 T1019M Disease 0.939 0.855 0.00 62 0.941 P78363 T1112N Disease 0.965 0.800 0.00 52 0.951 P78363 T1253M Disease 0.438 0.254 0.11 0 0.337 P78363 T1428M Disease NA 0.116 0.13 19 0.203 P78363 T1526M Disease NA 0.774 0.00 57 0.867 P78363 T1537M Disease NA 0.881 0.01 63 0.908 P78363 V1072A Disease 0.754 0.500 0.01 28 0.669 P78363 V1429A Disease NA 0.093 0.75 -5 0.075 P78363 V1433I Disease 0.134 0.174 0.52 -21 0.137 P78363 V1693I Disease 0.510 0.169 0.13 14 0.268 P78363 V1884E Disease 0.424 0.430 0.05 31 0.450 P78363 V1896D Disease 0.624 0.349 0.01 53 0.646 P78363 V2050L Disease 0.252 0.368 0.17 6 0.335 P78363 W1408L Disease 0.707 0.359 0.22 50 0.630 P78363 W1408R Disease 0.836 0.489 0.18 63 0.786 P78363 Y1652D Disease 0.808 0.518 0.05 60 0.886 P78363 Y2071F Disease 0.771 0.590 0.33 63 0.787 P78364 T693A Polymorphism 0.121 0.059 0.47 -28 0.023 P78368 E194G Polymorphism 0.531 0.297 0.03 49 0.646 P78368 E208Q Polymorphism 0.473 0.421 0.05 30 0.410 P78368 I196T Polymorphism 0.435 0.223 0.36 13 0.293 P78368 R217C Polymorphism 0.890 0.926 0.00 50 0.922 P78368 T223M Polymorphism 0.817 0.634 0.00 38 0.819 P78368 Y206H Polymorphism 0.842 0.609 0.07 51 0.908 P78380 K167N Polymorphism 0.221 0.121 0.45 40 0.204 P78385 E407K Disease 0.876 0.941 0.00 50 0.887 P78385 H493Y Polymorphism NA 0.205 1.00 32 0.062 P78386 R78H Disease 0.503 0.265 0.55 24 0.498 P78386 W155L Polymorphism 0.817 0.383 0.06 22 0.576 P78395 W7R Polymorphism NA 0.145 NA 50 0.028 P78410 A182T Polymorphism 0.107 0.467 0.72 23 0.155 P78410 R167T Polymorphism 0.100 0.349 1.00 54 0.248 P78410 S307N Polymorphism 0.092 0.131 0.16 0 0.152 P78417 A140D Polymorphism 0.191 0.528 0.61 -16 0.263 P78417 A236V Polymorphism 0.270 0.209 0.22 30 0.330 P78417 E208K Polymorphism 0.221 0.658 0.95 -15 0.348 P78423 A240V Polymorphism 0.104 0.023 0.61 -21 0.022 P78504 A31V Disease NA 0.226 0.05 32 0.359 P78504 C78S Disease NA 0.981 0.00 49 0.857 P78504 C92R Disease NA 0.865 0.00 72 0.911 P78504 C92Y Disease NA 0.918 0.00 65 0.921 P78504 F75S Disease NA 0.985 0.01 36 0.769 P78504 G33D Disease NA 0.967 0.00 38 0.783 P78504 G33S Disease NA 0.970 0.00 2 0.751 P78504 G33V Disease NA 0.940 0.00 54 0.907 P78504 I39S Disease NA 0.786 0.00 40 0.767 P78504 L37S Disease NA 0.970 0.00 40 0.787 P78504 L40P Disease NA 0.835 0.17 27 0.764 P78504 L79H Disease NA 0.949 0.00 62 0.924 P78504 A127T Disease NA 0.187 0.65 -7 0.161 P78504 A155P Disease NA 0.445 0.08 -23 0.407 P78504 C187S Disease 0.988 0.962 0.00 48 0.922 P78504 C187Y Disease 0.996 0.981 0.00 58 0.931 P78504 C220F Disease 0.996 0.938 0.00 54 0.969 P78504 C229G Disease 0.985 0.882 0.02 44 0.939 P78504 C229Y Disease 0.996 0.919 0.00 51 0.967 P78504 C271R Disease 0.994 0.769 0.20 69 0.969 P78504 C284F Disease 0.999 0.806 0.00 46 0.935 P78504 C438F Disease 0.999 0.599 0.00 66 0.906 P78504 C693Y Disease 0.914 0.750 0.00 73 0.988 P78504 C714Y Disease 0.889 0.815 0.00 77 0.974 P78504 C731S Disease 0.695 0.809 0.00 63 0.997 P78504 C740R Disease 0.857 0.795 0.00 79 0.991 P78504 C753R Disease 0.888 0.755 0.01 74 0.967 P78504 C902S Disease 0.693 0.698 0.05 56 0.776 P78504 C911Y Disease 0.520 0.903 0.01 69 0.913 P78504 G256S Disease 0.814 0.758 0.06 -4 0.757 P78504 G274D Disease 0.885 0.667 0.01 55 0.861 P78504 G386R Disease 0.648 0.568 0.02 47 0.593 P78504 I120N Disease NA 0.866 0.00 37 0.780 P78504 I152T Disease NA 0.849 0.00 30 0.750 P78504 N504S Disease 0.140 0.238 0.17 7 0.242 P78504 P123S Disease NA 0.795 0.02 13 0.582 P78504 P129R Disease NA 0.914 0.01 59 0.884 P78504 P163L Disease NA 0.478 0.28 27 0.461 P78504 P163R Disease NA 0.677 0.03 52 0.738 P78504 P269L Disease 0.899 0.644 0.00 45 0.840 P78504 R184C Disease 0.943 0.966 0.00 39 0.914 P78504 R184G Disease 0.826 0.942 0.00 44 0.879 P78504 R184H Disease 0.866 0.851 0.05 35 0.808 P78504 R184L Disease 0.832 0.896 0.01 38 0.868 P78504 R252G Disease 0.598 0.286 0.15 29 0.574 P78504 R818K Polymorphism 0.455 0.671 0.35 11 0.364 P78504 R889Q Disease 0.228 0.235 0.29 4 0.272 P78504 R937Q Disease NA 0.063 0.31 0 0.123 P78504 S913R Disease 0.062 0.247 0.53 16 0.211 P78504 V146I Polymorphism NA 0.043 0.20 -9 0.077 P78504 W224C Disease 0.954 0.788 0.00 54 0.925 P78504 W288C Disease 0.954 0.350 0.00 30 0.677 P78504 Y181N Disease 0.621 0.836 0.00 31 0.875 P78509 L997V Polymorphism 0.070 0.112 0.52 -2 0.091 P78509 T978A Polymorphism 0.213 0.149 0.00 37 0.189 P78524 I620T Polymorphism NA 0.655 0.00 32 0.608 P78524 K316N Polymorphism NA 0.433 0.02 53 0.552 P78524 S657F Polymorphism NA 0.181 0.01 22 0.295 P78524 S774G Polymorphism 0.498 0.754 0.03 29 0.628 P78527 A6S Polymorphism NA 0.159 0.03 -26 0.018 P78527 F649L Polymorphism 0.194 0.193 0.00 7 0.187 P78527 P695S Polymorphism 0.306 0.100 0.02 -24 0.149 P78527 T605S Polymorphism 0.538 0.108 0.00 -18 0.100 P78527 V420I Polymorphism 0.680 0.106 0.00 -13 0.124 P78527 A1237T Polymorphism 0.369 0.096 0.16 -17 0.098 P78527 A1619G Polymorphism 0.632 0.122 0.04 19 0.230 P78527 A2095V Polymorphism NA 0.137 0.00 19 0.245 P78527 D1588V Polymorphism 0.522 0.096 0.00 24 0.221 P78527 G1314V Polymorphism 0.383 0.152 0.00 1 0.176 P78527 G3149D Polymorphism NA 0.175 0.00 28 0.162 P78527 G3404E Polymorphism NA 0.163 1.00 35 0.130 P78527 I3434T Polymorphism NA 0.131 0.14 -12 0.092 P78527 L1190V Polymorphism 0.587 0.233 0.00 21 0.440 P78527 L3562M Polymorphism 0.640 0.284 0.01 42 0.519 P78527 L3800I Polymorphism 0.368 0.259 0.38 -15 0.193 P78527 M3932V Polymorphism 0.559 0.650 0.07 49 0.471 P78527 P3201S Polymorphism NA 0.060 0.50 -4 0.070 P78527 Q1603H Polymorphism 0.647 0.193 0.01 -3 0.223 P78527 R2598Q Polymorphism NA 0.381 0.00 66 0.292 P78527 R2899C Polymorphism NA 0.284 0.01 9 0.395 P78527 S2023P Polymorphism 0.550 0.218 0.13 1 0.415 P78527 T3198S Polymorphism NA 0.078 0.07 4 0.092 P78527 V3937M Polymorphism 0.230 0.855 0.88 -13 0.406 P78536 R202G Polymorphism NA 0.226 0.32 9 0.361 P78539 S413F Polymorphism 0.253 0.280 0.63 -1 0.306 P78543 V153M Polymorphism 0.320 0.029 0.14 -22 0.059 P78549 R21W Polymorphism NA 0.173 0.00 39 0.128 P78549 D239Y Polymorphism 0.987 0.941 0.00 79 0.933 P78549 I176T Polymorphism 0.845 0.788 0.01 32 0.798 P78556 V47M Polymorphism 0.153 0.051 0.11 10 0.044 P78559 F72L Polymorphism 0.661 0.970 0.00 37 0.869 P78559 A353S Polymorphism 0.306 0.308 0.13 18 0.371 P78559 K336T Polymorphism 0.443 0.339 0.09 48 0.444 P78559 A1690S Polymorphism 0.086 0.157 0.31 18 0.095 P78559 D1245N Polymorphism 0.578 0.131 0.01 42 0.311 P78559 D1461N Polymorphism 0.303 0.133 0.62 30 0.115 P78559 D2465N Polymorphism NA 0.157 0.25 25 0.150 P78559 H2214Y Polymorphism NA 0.275 0.06 31 0.207 P78559 I2461T Polymorphism NA 0.124 0.80 -14 0.056 P78559 K1605N Polymorphism NA 0.167 0.01 32 0.189 P78559 S1938R Polymorphism 0.096 0.073 0.05 33 0.058 P78559 W1650C Polymorphism 0.623 0.353 0.07 60 0.624 P78562 C77S Disease 0.974 0.817 0.00 47 0.898 P78562 C85F Disease 0.990 0.912 0.00 67 0.947 P78562 C85R Disease 0.988 0.954 0.00 75 0.946 P78562 C85Y Disease 0.992 0.870 0.00 68 0.946 P78562 F80S Disease 0.992 0.932 0.00 56 0.951 P78562 A573D Disease 0.438 0.869 0.01 67 0.903 P78562 A720T Disease 0.279 0.203 1.00 -33 0.180 P78562 C142F Disease 0.990 0.854 0.00 47 0.929 P78562 C693Y Disease 0.641 0.900 0.00 15 0.853 P78562 C733S Disease 0.970 0.807 0.00 52 0.927 P78562 C746W Disease 0.994 0.860 0.00 69 0.950 P78562 D237G Disease NA 0.416 0.09 0 0.374 P78562 F252S Disease 0.502 0.577 0.00 8 0.563 P78562 F731Y Disease 0.208 0.669 0.15 41 0.431 P78562 G579R Disease 0.577 0.963 0.00 73 0.933 P78562 G579V Disease 0.544 0.944 0.00 60 0.926 P78562 L138P Disease 0.686 0.914 0.03 54 0.910 P78562 L160R Disease 0.577 0.861 0.00 29 0.847 P78562 L555P Disease 0.982 0.935 0.00 66 0.944 P78562 M253I Disease 0.194 0.642 0.05 -21 0.370 P78562 N680K Disease 0.292 0.500 0.07 38 0.409 P78562 P534L Disease 0.511 0.885 0.02 56 0.889 P78562 Q621R Disease 0.252 0.877 0.00 54 0.819 P78562 R166C Disease 0.758 0.609 0.03 29 0.777 P78562 R567P Disease 0.557 0.855 0.04 24 0.580 P78562 R651P Disease 0.557 0.929 0.05 38 0.851 P78562 S141P Disease 0.475 0.926 0.01 66 0.930 P78562 W530C Disease 0.753 0.929 0.00 73 0.933 P78562 W749R Disease 0.992 0.943 0.00 59 0.958 P78562 Y317F Disease 0.187 0.664 1.00 -13 0.356 P79483 G102A Polymorphism 0.699 0.077 1.00 -46 0.044 P79483 V236M Polymorphism 0.774 0.500 0.03 25 0.776 P80075 A14V Polymorphism 0.174 0.299 1.00 -60 0.216 P80108 L17V Polymorphism 0.235 0.124 0.13 -42 0.049 P80108 I350V Polymorphism 0.087 0.117 0.71 34 0.078 P80108 M694V Polymorphism 0.174 0.049 0.17 16 0.085 P80108 T698I Polymorphism 0.068 0.120 0.49 39 0.068 P80192 R497Q Polymorphism 0.414 0.143 0.35 0 0.241 P80192 Y646C Polymorphism 0.448 0.180 0.18 7 0.108 P80303 Q338E Polymorphism 0.128 0.120 0.25 -41 0.107 P80365 A237V Disease 0.631 0.586 0.12 15 0.724 P80365 A328V Disease 0.911 0.756 0.00 23 0.849 P80365 D244N Disease 0.186 0.655 0.18 14 0.314 P80365 L179R Disease 0.824 0.611 0.08 5 0.745 P80365 L250R Disease 0.680 0.763 0.00 56 0.879 P80365 R186C Disease 0.816 0.775 0.02 41 0.826 P80365 R208C Disease 0.911 0.768 0.00 40 0.858 P80365 R208H Disease 0.798 0.780 0.01 3 0.793 P80365 R213C Disease 0.911 0.817 0.01 45 0.821 P80365 R279C Disease 0.775 0.562 0.18 36 0.766 P80365 R337C Disease 0.701 0.781 0.03 45 0.868 P80365 S180F Disease 0.610 0.775 0.70 6 0.617 P80370 S260N Polymorphism 0.163 0.146 0.57 38 0.133 P80404 R220K Disease 0.505 0.890 0.00 66 0.701 P81133 L175F Polymorphism 0.627 0.672 0.11 14 0.575 P81172 C70R Disease 0.813 0.660 0.00 78 0.872 P81172 C78Y Disease 0.854 0.447 0.00 69 0.768 P81172 G71D Disease 0.210 0.473 0.27 40 0.429 P81172 R59G Disease 0.691 0.429 0.00 50 0.448 P82094 Q430E Polymorphism NA 0.040 0.15 -15 0.038 P82094 Q682R Polymorphism NA 0.137 0.26 38 0.231 P82251 A70V Disease 0.167 0.299 0.54 -38 0.237 P82251 G63R Disease 0.858 0.912 0.03 69 0.930 P82251 I44T Disease 0.599 0.809 0.01 54 0.897 P82251 P52L Disease 0.990 0.879 0.91 59 0.935 P82251 W69L Disease 0.986 0.909 0.91 46 0.901 P82251 A126T Disease 0.569 0.813 0.02 30 0.590 P82251 A182T Disease 0.207 0.448 0.39 -31 0.277 P82251 A224V Disease 0.624 0.832 0.59 40 0.606 P82251 A331V Disease 0.574 0.636 0.29 47 0.583 P82251 A354T Disease 0.359 0.751 0.01 48 0.720 P82251 A382T Disease 0.366 0.352 0.30 -47 0.199 P82251 G105R Disease 0.982 0.716 0.00 65 0.971 P82251 G195R Disease 0.986 0.931 0.01 70 0.951 P82251 G259R Disease 0.628 0.903 0.00 56 0.914 P82251 I187F Disease 0.393 0.795 0.01 10 0.648 P82251 I241T Disease 0.523 0.154 0.05 46 0.402 P82251 L223M Polymorphism 0.263 0.635 0.22 -18 0.396 P82251 P261L Disease 0.796 0.547 0.94 -9 0.698 P82251 R333W Disease 0.856 0.961 0.00 56 0.939 P82251 S379R Disease 0.685 0.902 0.02 39 0.879 P82251 T123M Disease 0.443 0.711 0.12 8 0.570 P82251 V142A Polymorphism 0.100 0.246 0.59 20 0.163 P82251 V170M Disease 0.637 0.720 0.36 39 0.644 P82251 V330M Disease 0.526 0.713 0.05 37 0.854 P82251 W230R Disease 0.852 0.890 0.27 63 0.911 P82279 A161V Disease 0.433 0.207 0.02 46 0.432 P82279 C195F Disease 0.997 0.264 0.00 69 0.949 P82279 C250W Disease 0.999 0.319 0.00 75 0.883 P82279 C383Y Disease 0.998 0.799 0.00 72 0.989 P82279 C480G Disease 0.989 0.822 0.00 73 0.993 P82279 C480R Disease 0.995 0.895 0.00 82 0.992 P82279 C587Y Disease NA 0.851 0.03 60 0.750 P82279 C681Y Disease NA 0.946 0.00 75 0.944 P82279 C891G Disease NA 0.774 0.00 69 0.879 P82279 C948Y Disease NA 0.945 0.00 67 0.946 P82279 D584Y Disease NA 0.784 0.04 56 0.857 P82279 D837H Disease NA 0.368 0.46 57 0.604 P82279 E710Q Disease NA 0.469 0.45 43 0.541 P82279 F144V Disease 0.456 0.209 0.49 15 0.325 P82279 G846R Disease NA 0.612 0.17 57 0.633 P82279 G850S Disease NA 0.940 0.54 19 0.619 P82279 G959S Disease NA 0.305 0.54 -26 0.233 P82279 I852T Disease NA 0.785 0.39 -8 0.505 P82279 I989T Disease NA 0.691 0.12 46 0.622 P82279 M741T Disease NA 0.266 0.11 57 0.371 P82279 N894S Disease NA 0.161 0.67 16 0.160 P82279 N986I Disease NA 0.573 0.14 49 0.713 P82279 P836T Disease NA 0.435 0.48 49 0.341 P82279 R764C Disease NA 0.686 0.06 44 0.535 P82279 R769H Polymorphism NA 0.166 0.09 10 0.130 P82279 R769Q Polymorphism NA 0.175 0.33 43 0.258 P82279 T745M Disease NA 0.819 0.00 60 0.888 P82279 V162M Disease 0.094 0.208 0.15 9 0.194 P82279 V578E Disease NA 0.493 0.78 67 0.570 P82279 Y433C Disease 0.841 0.814 0.01 59 0.916 P82279 A1354T Disease 0.144 0.189 0.40 -12 0.207 P82279 C1181R Disease 0.986 0.192 0.00 73 0.759 P82279 C1218F Disease 0.981 0.214 0.02 63 0.671 P82279 C1321S Disease 0.971 0.265 0.00 55 0.748 P82279 G1103R Disease NA 0.836 0.06 65 0.762 P82279 G1205R Disease 0.717 0.186 0.00 63 0.580 P82279 I1100R Disease NA 0.370 0.37 65 0.623 P82279 I1100T Disease NA 0.307 0.43 43 0.283 P82279 L1071P Disease NA 0.763 0.21 47 0.582 P82279 L1107P Disease NA 0.709 0.06 44 0.598 P82279 L1107R Disease NA 0.588 0.06 64 0.650 P82279 M1041T Disease NA 0.143 0.45 59 0.263 P82279 N1317H Disease 0.151 0.215 0.20 57 0.281 P82279 R1383H Disease 0.264 0.221 0.04 -1 0.297 P82279 S1025I Disease NA 0.295 0.26 52 0.352 P82650 R170H Disease 0.404 0.862 NA 64 0.902 P82912 Q51H Polymorphism NA 0.095 0.00 23 0.152 P82912 R10W Polymorphism NA 0.234 0.26 12 0.087 P82921 R50C Polymorphism 0.601 0.180 0.01 -6 0.225 P82933 S13L Polymorphism NA 0.207 0.00 8 0.181 P82987 G713R Polymorphism 0.296 0.625 0.11 46 0.527 P82987 H146R Polymorphism 0.120 0.760 0.71 5 0.167 P82987 L869F Polymorphism NA 0.665 0.20 19 0.523 P82987 R855H Polymorphism NA 0.655 0.05 43 0.519 P82987 V661L Polymorphism 0.101 0.468 0.18 -16 0.036 P82987 T1370A Polymorphism NA 0.377 0.42 13 0.293 P82987 T1660I Polymorphism NA 0.687 0.24 36 0.549 P83111 R469K Polymorphism NA 0.031 1.00 -11 0.013 P84074 E21D Polymorphism 0.159 0.210 0.58 -70 0.165 P84996 L397V Disease NA 0.069 1.00 10 0.031 P84996 P374T Disease NA 0.099 0.63 32 0.039 P85298 G333R Polymorphism 0.152 0.474 0.21 17 0.167 P85298 Y172C Polymorphism 0.291 0.828 0.04 11 0.559 P98066 Q144R Polymorphism NA 0.275 0.30 -9 0.304 P98073 K77R Polymorphism NA 0.205 0.00 30 0.240 P98073 T65I Polymorphism NA 0.214 0.48 17 0.194 P98073 N660H Polymorphism 0.602 0.214 0.03 41 0.366 P98073 S545C Polymorphism NA 0.385 0.03 29 0.555 P98073 Y828C Polymorphism 0.816 0.785 0.03 42 0.816 P98082 S634N Polymorphism NA 0.180 0.03 17 0.154 P98082 T586I Polymorphism 0.235 0.147 0.21 -8 0.129 P98095 N387T Polymorphism NA 0.037 NA 13 0.014 P98095 S361G Polymorphism NA 0.066 NA 17 0.073 P98095 T854A Polymorphism 0.114 0.244 0.16 22 0.198 P98095 G1114R Polymorphism 0.638 0.827 0.00 61 0.782 P98155 L464I Polymorphism 0.432 0.433 0.24 -8 0.298 P98155 P262H Polymorphism 0.609 0.249 0.46 15 0.504 P98160 L303H Polymorphism NA 0.287 0.00 28 0.398 P98160 N765S Polymorphism 0.078 0.362 0.08 14 0.227 P98160 A3168T Polymorphism NA 0.144 0.30 37 0.349 P98160 C1532Y Disease 0.740 0.926 0.00 53 0.915 P98160 H3256Y Polymorphism NA 0.216 0.82 52 0.306 P98160 L1323V Polymorphism 0.211 0.209 0.07 19 0.196 P98160 R1186Q Polymorphism 0.087 0.329 0.11 38 0.133 P98160 S2995G Polymorphism NA 0.214 0.06 21 0.282 P98160 S4331N Polymorphism NA 0.102 0.91 20 0.131 P98160 V1967I Polymorphism 0.179 0.259 0.17 39 0.272 P98160 V3640I Polymorphism NA 0.455 0.19 35 0.268 P98161 A88V Polymorphism NA 0.092 NA -32 0.112 P98161 L13Q Disease NA 0.239 NA 2 0.024 P98161 L87M Polymorphism NA 0.137 NA 16 0.229 P98161 P61L Disease NA 0.145 NA -1 0.126 P98161 S75F Disease NA 0.175 NA 52 0.292 P98161 S99I Disease NA 0.172 NA 43 0.291 P98161 C210G Disease NA 0.460 NA 44 0.596 P98161 C508R Disease NA 0.337 0.00 67 0.644 P98161 F594Y Disease NA 0.219 NA 38 0.357 P98161 G381C Disease NA 0.385 NA 35 0.512 P98161 L845S Disease NA 0.228 NA 43 0.346 P98161 P738R Polymorphism NA 0.091 NA 32 0.085 P98161 Q164R Disease NA 0.169 NA 40 0.121 P98161 Q987H Disease NA 0.213 0.02 49 0.368 P98161 R324L Disease NA 0.153 NA 28 0.140 P98161 V690D Disease NA 0.257 NA 53 0.433 P98161 W139C Disease NA 0.360 NA 56 0.531 P98161 W967R Disease NA 0.545 0.00 73 0.852 P98161 A1516T Polymorphism NA 0.075 0.05 -3 0.061 P98161 A2752D Disease 0.602 0.460 0.21 64 0.750 P98161 A3512V Polymorphism NA 0.056 0.07 14 0.069 P98161 A3954P Disease NA 0.508 0.21 52 0.713 P98161 C2370R Disease 0.489 0.577 0.01 68 0.717 P98161 C2373Y Disease 0.703 0.476 0.42 60 0.744 P98161 D2604N Polymorphism 0.727 0.188 0.14 36 0.171 P98161 D2972N Polymorphism 0.288 0.339 0.20 49 0.321 P98161 D3815N Disease NA 0.260 0.29 33 0.277 P98161 E1811K Disease NA 0.185 NA 39 0.218 P98161 E2548Q Polymorphism 0.116 0.091 0.09 -35 0.076 P98161 E2771K Disease 0.371 0.334 0.16 35 0.460 P98161 E3632D Disease NA 0.163 0.28 -16 0.120 P98161 F3066L Disease 0.282 0.394 0.64 -14 0.269 P98161 F4155V Disease NA 0.218 0.03 30 0.246 P98161 G1166S Disease NA 0.647 NA 57 0.642 P98161 G2785D Disease 0.516 0.214 0.15 60 0.415 P98161 G2814R Disease 0.234 0.157 0.11 50 0.256 P98161 G2858S Disease 0.656 0.552 0.31 44 0.649 P98161 G3560R Disease NA 0.289 0.28 33 0.380 P98161 G3602S Disease NA 0.189 0.03 8 0.333 P98161 G4032D Disease NA 0.314 0.04 27 0.448 P98161 H2638R Disease 0.133 0.094 0.38 26 0.072 P98161 H2921P Disease 0.655 0.221 0.17 41 0.340 P98161 I2826T Disease 0.269 0.116 0.02 25 0.231 P98161 I3167F Disease 0.562 0.584 0.03 -11 0.697 P98161 I4045V Polymorphism NA 0.129 0.54 -33 0.073 P98161 L1114R Polymorphism NA 0.071 0.00 45 0.125 P98161 L2696R Disease 0.120 0.113 0.04 -22 0.061 P98161 L2763V Disease 0.297 0.154 0.03 54 0.166 P98161 L2816P Disease 0.449 0.232 0.01 34 0.400 P98161 L2993P Disease 0.696 0.375 0.01 39 0.616 P98161 L3511V Disease NA 0.049 0.06 -39 0.067 P98161 L3682P Disease NA 0.459 0.02 42 0.603 P98161 L3852P Disease NA 0.516 0.01 32 0.763 P98161 L4106P Polymorphism NA 0.457 0.01 46 0.633 P98161 M1092T Disease NA 0.085 NA 20 0.031 P98161 M2760T Polymorphism 0.325 0.243 0.12 47 0.340 P98161 M2764T Polymorphism 0.332 0.208 0.03 43 0.224 P98161 M3023V Polymorphism 0.202 0.175 0.27 34 0.214 P98161 M3678T Disease NA 0.212 0.01 31 0.254 P98161 P1168S Polymorphism NA 0.128 0.04 10 0.111 P98161 P1786L Polymorphism NA 0.148 NA 23 0.076 P98161 P2471L Disease 0.126 0.361 0.00 38 0.456 P98161 P2674S Polymorphism 0.185 0.139 0.06 -20 0.038 P98161 P2734T Polymorphism 0.288 0.109 0.04 31 0.182 P98161 P2802L Disease 0.194 0.194 0.21 33 0.284 P98161 P3193L Polymorphism 0.903 0.811 0.00 34 0.904 P98161 P3355L Disease 0.391 0.175 0.09 5 0.194 P98161 P3649L Disease NA 0.484 0.00 7 0.425 P98161 P4124S Polymorphism NA 0.199 0.53 25 0.177 P98161 P4255S Disease NA 0.155 NA 3 0.110 P98161 Q2519L Disease 0.653 0.175 0.02 35 0.216 P98161 Q3016R Disease 0.391 0.295 0.41 36 0.331 P98161 Q3751R Disease NA 0.728 0.01 55 0.844 P98161 Q4225P Disease NA 0.252 NA 32 0.379 P98161 R1340W Disease NA 0.360 0.00 47 0.458 P98161 R2200C Disease 0.662 0.157 0.10 54 0.338 P98161 R2329W Disease 0.725 0.278 0.10 42 0.479 P98161 R2392P Disease 0.372 0.345 0.13 50 0.576 P98161 R2408C Disease 0.742 0.271 0.02 50 0.563 P98161 R2765C Polymorphism 0.604 0.426 0.06 52 0.610 P98161 R2985G Disease 0.361 0.338 0.03 -3 0.287 P98161 R3039C Disease NA 0.511 0.03 34 0.745 P98161 R3247H Disease 0.427 0.398 0.27 3 0.345 P98161 R3719Q Disease NA 0.289 0.16 23 0.361 P98161 R3753W Disease NA 0.891 0.00 63 0.907 P98161 R4136G Disease NA 0.643 0.01 45 0.716 P98161 R4154C Disease NA 0.295 0.00 53 0.501 P98161 R4276W Disease NA 0.302 NA 54 0.407 P98161 S1684L Polymorphism NA 0.234 NA 7 0.345 P98161 S2423F Disease 0.452 0.152 0.02 44 0.257 P98161 S2958L Polymorphism 0.299 0.176 0.56 -13 0.256 P98161 T1242M Disease NA 0.242 0.10 68 0.329 P98161 T1649M Polymorphism NA 0.145 NA 54 0.262 P98161 T1667P Disease NA 0.210 NA 36 0.346 P98161 T1734K Polymorphism NA 0.125 NA 38 0.205 P98161 T2083I Disease NA 0.094 0.34 40 0.077 P98161 T2250M Disease 0.364 0.089 0.05 41 0.190 P98161 T2422K Disease 0.639 0.305 0.01 2 0.559 P98161 T2582M Polymorphism 0.219 0.102 0.04 30 0.144 P98161 T2649I Disease 0.762 0.126 0.04 31 0.246 P98161 T2708M Polymorphism 0.692 0.161 0.02 37 0.387 P98161 T2977N Polymorphism 0.467 0.431 0.01 47 0.533 P98161 T3382M Disease 0.455 0.171 0.01 -6 0.224 P98161 T3510M Disease NA 0.086 0.02 41 0.101 P98161 V1956E Disease NA 0.357 0.00 64 0.689 P98161 V2768M Disease 0.458 0.219 0.02 54 0.263 P98161 V2905I Polymorphism 0.248 0.106 0.40 -11 0.106 P98161 V3008L Disease 0.513 0.348 0.03 -23 0.516 P98161 V3008M Polymorphism 0.706 0.392 0.01 28 0.548 P98161 V3138M Disease 0.871 0.905 0.00 5 0.905 P98161 V3285I Disease 0.200 0.159 0.48 -39 0.198 P98161 V3375M Disease 0.270 0.191 0.06 -24 0.177 P98161 V4058A Polymorphism NA 0.144 0.44 0 0.093 P98161 W1399R Polymorphism NA 0.166 0.05 49 0.074 P98161 W3726S Disease NA 0.712 0.00 45 0.809 P98161 Y2092C Disease 0.318 0.210 0.00 61 0.228 P98161 Y2185D Disease 0.619 0.441 0.06 47 0.641 P98161 Y2336D Disease 0.838 0.397 0.03 42 0.610 P98161 Y2379C Polymorphism 0.671 0.249 0.14 46 0.527 P98164 N83S Polymorphism NA 0.288 1.00 13 0.187 P98164 A1287P Polymorphism 0.891 0.445 0.30 7 0.626 P98164 A2872T Polymorphism NA 0.367 0.33 -16 0.231 P98164 D1279A Polymorphism 0.367 0.616 0.79 27 0.328 P98164 H1083Q Polymorphism 0.372 0.333 0.73 24 0.205 P98164 I2065T Polymorphism 0.556 0.396 0.01 -31 0.510 P98164 I4210L Polymorphism NA 0.698 0.00 16 0.516 P98164 N2632D Polymorphism NA 0.458 1.00 -30 0.269 P98164 R2012K Polymorphism NA 0.460 1.00 5 0.220 P98164 R3011M Polymorphism NA 0.391 0.06 51 0.643 P98164 Y2522H Disease NA 0.842 0.00 47 0.874 P98169 A736T Polymorphism NA 0.056 0.89 -3 0.064 P98169 N760S Polymorphism NA 0.099 0.01 33 0.112 P98169 T791R Polymorphism NA 0.174 0.00 41 0.168 P98170 D242E Polymorphism NA 0.130 1.00 -4 0.133 P98170 N107S Polymorphism 0.056 0.124 0.90 -14 0.082 P98170 Q423P Polymorphism 0.322 0.295 0.13 -1 0.267 P98170 S133F Polymorphism 0.537 0.655 0.70 5 0.463 P98171 A104V Polymorphism NA 0.145 0.12 -1 0.208 P98172 I62T Disease 0.645 0.930 0.00 50 0.895 P98172 L98S Disease 0.870 0.578 0.03 29 0.727 P98172 P27R Disease 0.431 0.082 0.10 3 0.066 P98172 P54L Disease 0.895 0.595 0.59 22 0.723 P98172 C153S Disease 0.913 0.970 0.04 56 0.951 P98172 C153Y Disease 0.974 0.977 0.01 65 0.969 P98172 G151S Disease 0.916 0.937 0.13 52 0.924 P98172 G151V Disease 0.961 0.948 0.18 49 0.953 P98172 M158I Disease 0.737 0.662 0.04 56 0.861 P98172 M158V Disease 0.756 0.760 0.12 55 0.877 P98172 P119H Disease 0.978 0.823 0.00 52 0.956 P98172 P119S Disease 0.932 0.798 0.02 48 0.914 P98172 P119T Disease 0.947 0.848 0.01 49 0.939 P98172 Q115P Disease 0.867 0.926 0.00 43 0.887 P98172 S138F Disease 0.953 0.934 0.01 48 0.923 P98172 S182R Disease 0.355 0.172 0.28 5 0.276 P98172 T111I Disease 0.803 0.743 0.01 42 0.838 P98172 T137A Disease 0.290 0.859 0.06 42 0.691 P98172 T155P Disease 0.736 0.854 0.05 45 0.866 P98172 T172M Polymorphism 0.269 0.075 0.11 10 0.124 P98172 V189A Polymorphism 0.218 0.104 0.20 -14 0.085 P98174 E380A Disease 0.986 0.830 0.00 36 0.932 P98174 R443H Disease 0.878 0.782 0.33 20 0.814 P98174 R522H Disease 0.918 0.781 0.15 34 0.872 P98174 R610Q Disease 0.961 0.908 0.06 50 0.943 P98174 S205I Disease NA 0.108 0.12 -65 0.095 P98182 T140M Polymorphism NA 0.288 0.02 -4 0.223 P98187 P447Q Polymorphism 0.384 0.529 0.22 -6 0.456 P98194 A304T Disease 0.856 0.841 0.03 41 0.789 P98194 A450T Polymorphism 0.204 0.376 0.26 6 0.344 P98194 C490F Disease 0.846 0.920 0.01 63 0.926 P98194 G309C Disease 0.913 0.868 0.00 45 0.826 P98194 G645R Disease 0.996 0.915 0.00 74 0.892 P98194 L318P Disease 0.920 0.872 0.00 67 0.816 P98194 L341P Disease 0.967 0.821 0.00 55 0.919 P98194 L584P Disease 0.785 0.909 0.00 63 0.889 P98194 M641R Disease 0.966 0.957 0.00 70 0.827 P98194 P201L Disease NA 0.529 0.29 -7 0.448 P98194 P744R Disease 0.596 0.703 0.12 40 0.811 P98194 T709M Disease 0.841 0.623 0.00 27 0.790 P98196 M317V Polymorphism 0.182 0.205 0.69 -38 0.051 P98196 V1091I Polymorphism NA 0.103 0.85 -61 0.136 P99999 G42S Disease 0.672 0.842 0.00 27 0.862 Q00005 G36V Polymorphism 0.752 0.961 0.00 48 0.888 Q00056 T70P Polymorphism NA 0.117 0.27 -19 0.030 Q00056 L140P Polymorphism NA 0.275 0.37 -38 0.184 Q00056 L178F Polymorphism NA 0.195 0.05 23 0.323 Q00056 P317S Polymorphism NA 0.126 0.35 41 0.105 Q00056 T251P Polymorphism 0.738 0.850 0.27 47 0.816 Q00059 S12T Polymorphism NA 0.123 0.13 -11 0.103 Q00266 A55D Disease 0.858 0.940 0.00 58 0.925 Q00266 S38N Disease 0.707 0.748 0.01 49 0.884 Q00266 E344A Disease 0.287 0.232 0.28 -2 0.291 Q00266 G336R Disease 0.729 0.840 0.00 64 0.907 Q00266 G378S Disease 0.860 0.866 0.00 60 0.933 Q00266 I322M Disease 0.683 0.741 0.00 62 0.903 Q00266 L305P Disease 0.860 0.900 0.00 45 0.885 Q00266 P357L Disease 0.933 0.891 0.00 41 0.908 Q00266 Q119H Polymorphism 0.564 0.608 0.01 29 0.597 Q00266 R199C Disease 0.870 0.907 0.03 42 0.874 Q00266 R264C Disease 0.962 0.940 0.00 56 0.929 Q00266 R264H Disease 0.912 0.892 0.00 56 0.913 Q00266 R356Q Disease 0.603 0.873 0.00 50 0.890 Q00325 G72E Disease 0.907 0.914 0.00 57 0.935 Q00341 V229I Polymorphism 0.111 0.109 0.63 0 0.132 Q00341 W1264L Polymorphism 0.114 0.616 0.00 49 0.498 Q00526 I124T Polymorphism 0.437 0.188 0.00 38 0.414 Q00526 M264T Polymorphism NA 0.229 0.42 -31 0.155 Q00526 R214H Polymorphism 0.617 0.586 0.45 -13 0.514 Q00526 T226I Polymorphism NA 0.209 0.43 -14 0.257 Q00532 L66P Polymorphism 0.916 0.897 0.00 40 0.901 Q00532 K341N Polymorphism NA 0.234 0.08 11 0.398 Q00532 L329V Polymorphism NA 0.135 0.68 12 0.137 Q00532 Q274E Polymorphism NA 0.313 0.38 -27 0.197 Q00534 D110N Polymorphism 0.251 0.692 0.04 -23 0.476 Q00535 E225D Polymorphism NA 0.225 0.49 -27 0.290 Q00597 S26F Polymorphism 0.672 0.095 0.00 38 0.401 Q00597 I312V Polymorphism 0.118 0.112 0.29 -4 0.085 Q00604 A63D Disease NA 0.375 NA 38 0.185 Q00604 C39R Disease NA 0.756 NA 69 0.748 Q00604 C65W Disease NA 0.453 NA 73 0.292 Q00604 C65Y Disease NA 0.431 NA 69 0.264 Q00604 C69S Disease NA 0.405 NA 56 0.194 Q00604 C96W Disease NA 0.393 NA 74 0.223 Q00604 C96Y Disease NA 0.353 NA 69 0.219 Q00604 D23E Polymorphism NA 0.139 NA 3 0.047 Q00604 H42R Disease NA 0.263 NA 40 0.136 Q00604 K58N Disease NA 0.230 NA 34 0.137 Q00604 L13R Disease NA 0.759 NA 59 0.727 Q00604 L16P Disease NA 0.289 NA 39 0.108 Q00604 L61F Disease NA 0.169 NA 21 0.103 Q00604 L61P Disease NA 0.522 NA 19 0.570 Q00604 R41K Disease NA 0.216 NA 43 0.159 Q00604 R74C Disease NA 0.329 NA 46 0.178 Q00604 R90P Disease NA 0.389 NA 23 0.174 Q00604 S75C Disease NA 0.140 NA 28 0.063 Q00604 S75P Disease NA 0.140 NA 11 0.063 Q00604 V60E Disease NA 0.269 NA 66 0.152 Q00604 Y44C Disease NA 0.339 NA 51 0.186 Q00604 A105T Disease NA 0.084 NA 1 0.049 Q00604 C110G Disease NA 0.346 NA 54 0.215 Q00604 I123N Disease NA 0.608 NA 53 0.613 Q00604 K104Q Disease NA 0.185 NA 0 0.178 Q00604 L124F Disease NA 0.158 NA 34 0.117 Q00604 R121G Disease NA 0.570 NA 43 0.573 Q00604 R121Q Disease NA 0.514 NA 39 0.571 Q00604 R121W Disease NA 0.657 NA 53 0.567 Q00604 S101F Disease NA 0.110 NA 33 0.078 Q00604 Y120C Disease NA 0.602 NA 67 0.659 Q00653 E14K Polymorphism NA 0.385 0.04 31 0.235 Q00722 N324I Polymorphism 0.927 0.456 0.00 56 0.813 Q00722 P664L Polymorphism NA 0.377 0.17 19 0.384 Q00722 R598H Polymorphism 0.566 0.785 0.31 21 0.575 Q00887 L18V Polymorphism 0.098 0.699 0.14 -26 0.197 Q00887 A176T Polymorphism 0.213 0.596 0.97 8 0.356 Q00887 H397R Polymorphism 0.214 0.359 0.89 1 0.245 Q00887 I325T Polymorphism 0.119 0.207 0.92 16 0.157 Q00887 Q374L Polymorphism 0.137 0.477 0.51 7 0.165 Q00889 A258T Polymorphism 0.094 0.114 1.00 -51 0.091 Q00889 I404S Polymorphism 0.100 0.462 1.00 -7 0.142 Q00889 L155F Polymorphism 0.258 0.612 0.14 -4 0.393 Q00889 L180W Polymorphism 0.120 0.643 0.80 -66 0.090 Q00889 M161T Polymorphism 0.213 0.659 0.57 -34 0.271 Q00889 R191S Polymorphism 0.073 0.873 0.15 -28 0.195 Q008S8 A594T Polymorphism 0.339 0.238 0.20 15 0.047 Q008S8 E527K Polymorphism NA 0.189 0.11 19 0.204 Q008S8 Q483H Polymorphism NA 0.128 0.01 6 0.149 Q00973 A516V Polymorphism NA 0.051 0.75 -20 0.080 Q00973 G172R Polymorphism NA 0.151 0.10 4 0.216 Q00975 N167K Polymorphism NA 0.820 0.00 60 0.950 Q00975 E1436K Polymorphism 0.739 0.506 0.01 50 0.740 Q00G26 A6V Polymorphism NA 0.046 0.00 -29 0.075 Q00LT1 C2Y Disease NA 0.436 NA 42 0.327 Q00LT1 R17C Polymorphism NA 0.226 NA 48 0.225 Q00LT1 V30M Disease NA 0.046 NA 40 0.038 Q01094 G200S Polymorphism 0.087 0.295 0.80 -32 0.162 Q01094 G393S Polymorphism 0.438 0.095 0.58 -39 0.112 Q01094 T311N Polymorphism 0.100 0.167 0.15 -18 0.155 Q01113 G331R Polymorphism 0.079 0.054 0.62 -7 0.041 Q01113 Y288C Polymorphism 0.704 0.813 0.12 32 0.635 Q01118 I407V Polymorphism 0.097 0.105 0.05 9 0.172 Q01118 M600L Polymorphism 0.078 0.768 1.00 -33 0.236 Q01118 A1313V Polymorphism 0.401 0.797 0.15 -48 0.501 Q01196 R139Q Disease 0.917 0.961 0.00 68 0.944 Q01196 R174Q Disease 0.914 0.964 0.00 41 0.902 Q01196 S431R Polymorphism 0.740 0.677 0.20 23 0.792 Q01196 S433R Polymorphism 0.740 0.706 0.02 27 0.848 Q01201 T396M Polymorphism 0.434 0.341 0.09 30 0.488 Q01362 N211K Polymorphism 0.152 0.088 0.38 24 0.060 Q01362 T143M Polymorphism 0.282 0.149 0.14 -8 0.091 Q01415 I182V Polymorphism 0.160 0.178 1.00 2 0.118 Q01432 A320V Disease 0.435 0.301 0.32 0 0.418 Q01432 M324T Disease 0.786 0.923 0.00 54 0.927 Q01432 N310K Disease 0.796 0.958 0.00 39 0.792 Q01432 P585L Disease 0.908 0.901 0.07 36 0.902 Q01432 Q712P Disease 0.527 0.575 0.10 25 0.733 Q01432 R185W Polymorphism 0.674 0.178 0.02 35 0.420 Q01432 R331C Disease 0.935 0.886 0.00 30 0.905 Q01432 R402C Disease 0.933 0.961 0.00 41 0.906 Q01432 R573C Disease 0.971 0.976 0.00 46 0.925 Q01432 V311L Disease 0.428 0.762 0.07 44 0.797 Q01432 W450R Disease 0.956 0.952 0.00 49 0.937 Q01453 A67P Disease 0.642 0.951 0.01 52 0.878 Q01453 A67T Disease 0.441 0.839 0.02 32 0.760 Q01453 D37V Disease 0.736 0.870 0.02 53 0.902 Q01453 G93R Disease 0.963 0.982 0.00 59 0.922 Q01453 H12Q Disease 0.950 0.848 0.00 38 0.916 Q01453 L16P Disease 0.907 0.876 0.10 44 0.859 Q01453 L19P Disease 0.960 0.988 0.00 60 0.965 Q01453 L71P Disease 0.959 0.945 0.00 43 0.925 Q01453 L80P Disease 0.765 0.909 0.01 47 0.875 Q01453 L80R Disease 0.700 0.911 0.01 49 0.894 Q01453 M69K Disease 0.933 0.943 0.00 57 0.956 Q01453 S22F Disease 0.637 0.855 0.01 45 0.856 Q01453 S72L Disease 0.482 0.818 0.00 24 0.743 Q01453 S72P Disease 0.508 0.887 0.00 52 0.873 Q01453 S72W Disease 0.871 0.856 0.00 37 0.876 Q01453 S76I Disease 0.484 0.694 0.03 24 0.728 Q01453 S79C Disease 0.637 0.583 0.01 22 0.710 Q01453 S79P Disease 0.543 0.827 0.03 40 0.795 Q01453 T23R Disease 0.929 0.991 0.00 65 0.950 Q01453 V30M Disease 0.468 0.645 0.01 45 0.582 Q01453 V65F Disease 0.857 0.822 0.00 32 0.846 Q01453 W28R Disease 0.991 0.991 0.00 68 0.937 Q01453 C109R Disease 0.509 0.955 0.00 61 0.927 Q01453 G100E Disease 0.447 0.877 0.01 72 0.899 Q01453 G100R Disease 0.536 0.935 0.01 72 0.922 Q01453 G107V Disease 0.322 0.436 0.25 29 0.521 Q01453 G150C Disease 0.958 0.932 0.00 47 0.918 Q01453 G150D Disease 0.923 0.972 0.00 68 0.955 Q01453 L105R Disease 0.728 0.914 0.03 57 0.910 Q01453 L147R Disease 0.500 0.947 0.01 49 0.891 Q01453 R157G Polymorphism 0.914 0.947 0.00 53 0.957 Q01453 R157W Disease 0.980 0.972 0.00 56 0.972 Q01453 S149R Disease 0.809 0.942 0.05 55 0.939 Q01453 T118M Disease 0.727 0.895 0.00 53 0.890 Q01459 V274I Polymorphism 0.264 0.140 0.12 46 0.164 Q01484 E1425G Disease NA 0.359 0.25 19 0.322 Q01484 E3898K Disease NA 0.270 0.01 16 0.414 Q01484 L3707I Disease NA 0.244 0.01 -1 0.244 Q01484 R3873W Disease NA 0.500 0.00 37 0.714 Q01484 T3711N Disease NA 0.139 0.00 23 0.164 Q01518 C236G Polymorphism 0.302 0.508 0.58 -2 0.305 Q01518 Y249D Polymorphism 0.373 0.214 0.56 -12 0.079 Q01523 R71H Polymorphism NA 0.177 0.55 31 0.129 Q01534 I216F Polymorphism 0.531 0.750 0.01 47 0.687 Q01534 P195R Polymorphism 0.575 0.261 0.35 36 0.661 Q01546 T629M Polymorphism 0.368 0.224 0.00 43 0.251 Q01628 H3Q Polymorphism 0.197 0.190 0.14 23 0.315 Q01638 A433T Polymorphism 0.306 0.281 0.24 46 0.410 Q01638 Q501K Polymorphism 0.131 0.061 0.49 4 0.096 Q01658 E171D Polymorphism NA 0.059 0.87 4 0.039 Q01664 Q218H Polymorphism 0.087 0.035 NA 20 0.030 Q01718 P27R Polymorphism 0.727 0.757 0.01 62 0.872 Q01718 S74I Disease 0.958 0.552 0.00 24 0.851 Q01718 C251F Disease 0.976 0.924 0.00 43 0.925 Q01718 D103N Disease 0.536 0.852 0.31 52 0.731 Q01718 D107N Disease 0.835 0.752 0.04 46 0.837 Q01718 R128C Disease 0.982 0.923 0.00 74 0.958 Q01718 R137W Disease 0.827 0.879 0.00 55 0.927 Q01718 R146H Disease 0.746 0.815 0.00 60 0.799 Q01718 S120R Disease 0.646 0.794 0.14 25 0.846 Q01718 Y254C Disease 0.869 0.895 0.01 30 0.851 Q01726 D84E Polymorphism 0.324 0.899 0.00 42 0.764 Q01726 R67Q Polymorphism 0.633 0.910 0.03 36 0.738 Q01726 G104S Polymorphism 0.475 0.677 0.07 28 0.556 Q01726 I120T Polymorphism 0.551 0.509 0.00 16 0.533 Q01726 N281S Polymorphism 0.412 0.495 0.01 9 0.522 Q01726 R163Q Polymorphism 0.274 0.685 0.33 13 0.644 Q01726 V156L Polymorphism 0.200 0.748 0.03 16 0.509 Q01740 H97Q Polymorphism 0.582 0.489 0.33 15 0.566 Q01740 F327L Polymorphism 0.462 0.671 0.31 25 0.508 Q01740 I303V Polymorphism 0.280 0.103 1.00 -16 0.123 Q01740 I322V Polymorphism 0.366 0.180 0.19 -10 0.207 Q01740 R223Q Polymorphism 0.666 0.808 0.01 40 0.828 Q01740 S227T Polymorphism 0.357 0.298 0.60 -30 0.373 Q01804 A194G Polymorphism NA 0.062 0.09 38 0.077 Q01831 K86R Polymorphism 0.302 0.051 NA -2 0.067 Q01831 L16V Polymorphism NA 0.057 NA -5 0.073 Q01831 L48F Polymorphism 0.152 0.041 NA 4 0.057 Q01831 C514S Polymorphism 0.447 0.128 1.00 -15 0.029 Q01831 F287C Polymorphism 0.574 0.142 0.05 15 0.228 Q01831 K511Q Polymorphism 0.488 0.165 0.35 17 0.214 Q01831 K928Q Polymorphism 0.163 0.142 NA 26 0.145 Q01831 M513I Polymorphism 0.282 0.057 0.41 -11 0.030 Q01831 P334H Disease 0.426 0.090 0.00 20 0.148 Q01831 Q632E Polymorphism 0.244 0.066 0.60 4 0.096 Q01831 R314Q Polymorphism 0.450 0.393 0.04 50 0.672 Q01831 R492H Polymorphism 0.408 0.101 0.02 17 0.194 Q01831 R671H Polymorphism 0.747 0.478 0.06 30 0.716 Q01831 T689M Polymorphism 0.695 0.322 0.16 6 0.590 Q01860 L226F Polymorphism 0.406 0.420 0.70 -4 0.307 Q01860 T322A Polymorphism NA 0.150 0.51 22 0.135 Q01955 G43R Polymorphism NA 0.818 NA 68 0.917 Q01955 G297E Disease 0.995 0.717 NA 41 0.880 Q01955 G407R Disease NA 0.856 NA 67 0.981 Q01955 G532D Disease NA 0.845 NA 76 0.984 Q01955 G640R Disease NA 0.851 NA 69 0.984 Q01955 G739R Disease NA 0.841 NA 66 0.982 Q01955 G853R Disease NA 0.879 NA 78 0.983 Q01955 G985V Disease 0.579 0.812 NA 59 0.963 Q01955 P574L Polymorphism NA 0.500 NA 32 0.509 Q01955 R408H Polymorphism NA 0.245 NA -27 0.436 Q01955 D1347E Disease 0.200 0.432 NA -23 0.282 Q01955 G1015E Disease NA 0.882 NA 72 0.984 Q01955 G1167R Disease NA 0.889 NA 58 0.966 Q01955 G1207E Disease NA 0.786 NA 69 0.961 Q01955 G1216R Disease NA 0.864 NA 58 0.965 Q01955 G1277S Disease 0.685 0.788 NA 49 0.920 Q01955 G1334E Disease 0.790 0.554 NA 70 0.958 Q01955 I1330T Disease 0.137 0.204 NA 10 0.167 Q01955 L1474P Polymorphism 0.822 0.910 NA 30 0.896 Q01955 R1215Q Disease NA 0.412 NA -12 0.350 Q01955 R1661C Disease NA 0.945 NA 66 0.943 Q01959 R237Q Polymorphism 0.411 0.467 0.14 5 0.353 Q01968 A797P Disease 0.395 0.193 0.15 44 0.377 Q01968 C498Y Disease 0.854 0.934 0.00 59 0.932 Q01968 D451G Disease 0.622 0.834 0.00 61 0.903 Q01968 F463S Disease 0.981 0.894 0.00 50 0.934 Q01968 G357E Disease 0.766 0.846 0.01 53 0.898 Q01968 G421E Disease 0.983 0.916 0.00 70 0.940 Q01968 H375Y Disease 0.996 0.917 0.00 72 0.940 Q01968 H524Q Disease 0.998 0.874 0.00 49 0.924 Q01968 H524R Disease 0.997 0.934 0.00 58 0.946 Q01968 I533S Disease 0.679 0.854 0.04 5 0.786 Q01968 I768N Disease 0.852 0.472 0.00 43 0.673 Q01968 N424D Disease 0.993 0.914 0.00 67 0.942 Q01968 P526L Disease 0.990 0.911 0.00 29 0.926 Q01968 R318C Disease 0.891 0.780 0.01 64 0.925 Q01968 R337P Disease 0.466 0.883 0.07 59 0.891 Q01968 R500G Disease 0.993 0.904 0.00 65 0.944 Q01968 R500Q Disease 0.995 0.898 0.00 70 0.944 Q01968 S522R Disease 0.995 0.946 0.00 55 0.943 Q01968 V372G Disease 0.709 0.830 0.00 62 0.902 Q01968 V508D Disease 0.802 0.660 0.01 44 0.821 Q01968 Y479C Disease 0.878 0.878 0.00 60 0.927 Q01968 Y513C Disease 0.980 0.916 0.00 73 0.940 Q01970 R483H Polymorphism 0.300 0.329 0.06 5 0.393 Q01973 G624R Polymorphism 0.266 0.894 0.10 42 0.612 Q01973 Y646C Polymorphism 0.878 0.825 0.00 46 0.886 Q01974 C182Y Disease 0.825 0.919 0.00 43 0.890 Q01974 D672N Polymorphism 0.361 0.396 0.09 -18 0.364 Q01974 D935E Polymorphism NA 0.071 NA 4 0.029 Q01974 G490A Polymorphism 0.595 0.595 0.92 8 0.442 Q01974 N620K Disease 0.566 0.870 0.00 69 0.736 Q01974 R184C Disease 0.865 0.500 0.01 49 0.781 Q01974 R189W Disease 0.900 0.491 0.02 50 0.763 Q01974 R244Q Polymorphism NA 0.084 0.35 18 0.131 Q01974 R366W Disease 0.912 0.803 0.00 60 0.940 Q01974 S557L Polymorphism 0.290 0.168 0.11 -4 0.286 Q01974 S762L Polymorphism 0.591 0.244 0.17 32 0.493 Q02078 N263S Polymorphism 0.081 0.140 0.52 0 0.111 Q02083 V151I Polymorphism NA 0.066 0.26 -8 0.086 Q02094 S79N Disease 0.458 0.664 0.01 50 0.712 Q02094 G279E Disease 0.308 0.932 0.00 68 0.934 Q02094 G280R Disease 0.634 0.927 0.17 50 0.898 Q02094 G380V Disease 0.785 0.928 0.00 32 0.867 Q02094 V270I Disease 0.256 0.667 0.09 -8 0.431 Q02108 V25I Polymorphism NA 0.082 0.44 15 0.045 Q02127 K7Q Polymorphism NA 0.066 0.14 14 0.070 Q02156 A654T Polymorphism 0.132 0.150 0.56 -31 0.176 Q02156 T563M Polymorphism 0.606 0.429 0.26 8 0.577 Q02161 W16C Polymorphism NA 0.272 0.30 -9 0.203 Q02161 E193K Polymorphism 0.075 0.260 0.79 1 0.189 Q02161 T201R Polymorphism 0.115 0.384 0.17 29 0.183 Q02161 V306I Polymorphism 0.073 0.344 0.65 -9 0.196 Q02161 Y311C Polymorphism 0.067 0.770 0.20 40 0.210 Q02218 V1018I Polymorphism 0.080 0.247 0.48 -11 0.168 Q02223 F75V Polymorphism NA 0.637 NA 33 0.433 Q02223 I65V Polymorphism NA 0.097 NA -21 0.045 Q02223 A153T Polymorphism NA 0.181 NA 43 0.234 Q02252 G446R Disease 0.900 0.881 0.00 61 0.924 Q02318 G145E Disease 0.980 0.667 0.00 70 0.945 Q02318 R395C Disease 0.999 0.873 0.00 70 0.946 Q02318 R395S Disease 0.999 0.898 0.00 62 0.946 Q02318 R405Q Disease 0.989 0.844 0.00 28 0.936 Q02318 R474Q Disease 0.989 0.900 0.00 71 0.940 Q02318 R474W Disease 0.997 0.938 0.00 72 0.946 Q02318 R479C Disease 0.919 0.765 0.00 48 0.887 Q02318 T175M Polymorphism 0.629 0.310 0.08 22 0.565 Q02383 Q43K Polymorphism 0.099 0.240 0.07 17 0.199 Q02383 G368R Polymorphism NA 0.422 0.07 27 0.520 Q02383 H279Y Polymorphism 0.442 0.623 0.02 37 0.718 Q02383 S274N Polymorphism 0.083 0.056 1.00 -33 0.056 Q02386 P303R Polymorphism 0.581 0.351 0.02 42 0.697 Q02386 T299A Polymorphism 0.297 0.222 0.08 32 0.385 Q02388 K142R Disease NA 0.613 0.00 8 0.507 Q02388 P595L Disease NA 0.249 0.58 33 0.306 Q02388 V547F Polymorphism NA 0.229 0.05 40 0.363 Q02388 G1347R Disease NA 0.881 0.00 48 0.911 Q02388 G1519D Disease NA 0.875 0.00 60 0.997 Q02388 G1522E Disease NA 0.876 0.00 63 0.999 Q02388 G1557R Disease NA 0.878 0.00 67 0.997 Q02388 G1604R Disease 0.997 0.903 0.00 77 0.995 Q02388 G1652R Disease 0.769 0.898 0.00 60 0.986 Q02388 G1703E Disease 0.135 0.880 0.10 57 0.958 Q02388 G1776R Disease 0.998 0.873 0.00 73 0.989 Q02388 G1782R Disease 0.998 0.904 0.00 73 0.984 Q02388 G1791E Disease 0.799 0.885 0.00 81 0.984 Q02388 G1812R Disease 0.726 0.878 0.00 59 0.991 Q02388 G1982W Disease NA 0.851 0.00 46 0.928 Q02388 G2003R Disease NA 0.897 0.00 52 0.988 Q02388 G2006A Disease NA 0.864 0.00 41 0.871 Q02388 G2006D Disease NA 0.890 0.00 56 0.994 Q02388 G2009R Disease NA 0.893 0.00 63 0.999 Q02388 G2015E Disease NA 0.889 0.04 56 0.990 Q02388 G2025A Disease 0.463 0.846 1.00 60 0.992 Q02388 G2028A Disease 0.390 0.865 0.28 50 0.894 Q02388 G2028R Disease 0.705 0.889 0.01 62 0.995 Q02388 G2031S Disease 0.998 0.879 0.24 61 0.957 Q02388 G2034R Disease 0.996 0.896 0.01 71 0.995 Q02388 G2034W Disease 0.998 0.863 0.00 68 0.995 Q02388 G2037E Disease 0.996 0.898 0.01 65 0.996 Q02388 G2040D Disease 0.996 0.901 0.00 75 0.995 Q02388 G2040S Disease 0.995 0.888 0.03 56 0.992 Q02388 G2040V Disease 0.997 0.906 0.01 68 0.995 Q02388 G2043R Disease 0.997 0.892 0.00 76 0.995 Q02388 G2043W Disease 0.998 0.862 0.00 69 0.993 Q02388 G2046V Disease 0.999 0.893 0.00 70 0.990 Q02388 G2049E Disease 0.999 0.860 0.01 84 0.907 Q02388 G2055E Disease 0.998 0.794 0.01 71 0.993 Q02388 G2064R Disease 0.996 0.728 0.00 65 0.995 Q02388 G2073D Disease 0.999 0.879 0.01 62 0.993 Q02388 G2076D Disease 0.841 0.891 0.00 54 0.980 Q02388 G2079E Disease 0.998 0.886 0.01 65 0.994 Q02388 G2079R Disease 0.998 0.889 0.01 68 0.994 Q02388 G2132D Disease 0.841 0.835 0.00 71 0.983 Q02388 G2192S Disease NA 0.872 0.01 56 0.994 Q02388 G2207R Disease NA 0.880 0.47 68 0.999 Q02388 G2242R Disease NA 0.887 0.00 68 0.999 Q02388 G2251E Disease NA 0.907 0.00 75 0.999 Q02388 G2263V Disease NA 0.861 0.00 59 0.994 Q02388 G2366S Disease NA 0.838 0.05 54 0.926 Q02388 G2369S Disease NA 0.838 0.07 37 0.854 Q02388 G2569R Disease NA 0.882 0.01 65 0.999 Q02388 G2575R Disease NA 0.884 0.01 73 0.999 Q02388 G2623C Disease 0.316 0.888 0.00 47 0.757 Q02388 G2653R Disease 0.998 0.885 0.00 66 0.993 Q02388 G2671V Disease 0.816 0.883 0.01 44 0.887 Q02388 G2674D Disease 0.991 0.859 0.00 64 0.994 Q02388 G2674R Disease 0.993 0.855 0.00 67 0.994 Q02388 G2713D Disease 0.446 0.854 0.00 39 0.868 Q02388 G2713R Disease 0.538 0.893 0.00 43 0.876 Q02388 G2740A Disease 0.992 0.846 0.00 57 0.994 Q02388 G2749R Disease NA 0.859 0.08 64 0.947 Q02388 G2775S Disease 0.993 0.862 0.00 11 0.943 Q02388 M2798K Disease NA 0.432 0.72 40 0.456 Q02388 P1277L Disease NA 0.540 0.07 36 0.529 Q02388 R1772W Disease 0.572 0.536 0.02 26 0.743 Q02388 R2008C Disease NA 0.845 0.02 52 0.960 Q02388 R2008G Disease NA 0.654 0.12 44 0.658 Q02388 R2063W Disease 0.610 0.510 0.02 41 0.758 Q02388 R2791W Disease NA 0.784 0.04 43 0.826 Q02410 S184A Polymorphism NA 0.102 0.00 -29 0.035 Q02413 D828N Polymorphism 0.444 0.373 0.12 37 0.429 Q02413 L821Q Polymorphism 0.135 0.081 0.18 -47 0.025 Q02413 Y528S Polymorphism 0.065 0.252 0.39 33 0.279 Q02413 Y841F Polymorphism 0.270 0.579 0.00 33 0.560 Q02447 T164A Polymorphism 0.073 0.089 0.22 32 0.069 Q02487 N11S Polymorphism 0.075 0.058 0.80 -61 0.011 Q02487 I776V Polymorphism 0.120 0.199 0.91 -23 0.143 Q02535 S111A Polymorphism 0.126 0.077 0.00 -8 0.182 Q02539 T99I Polymorphism 0.655 0.916 0.01 30 0.827 Q02539 S115F Polymorphism 0.561 0.204 0.03 -19 0.430 Q02548 A322T Polymorphism 0.061 0.075 0.93 -37 0.045 Q02643 A176V Disease 0.918 0.779 0.00 16 0.855 Q02643 A222E Disease 0.520 0.323 0.00 20 0.537 Q02643 E121D Polymorphism 0.130 0.134 0.67 -4 0.125 Q02643 F242C Disease 0.784 0.653 0.00 32 0.791 Q02643 K329E Disease 0.289 0.653 0.01 58 0.730 Q02643 L144H Disease 0.993 0.917 0.00 49 0.947 Q02742 S158C Polymorphism 0.556 0.843 0.01 45 0.871 Q02750 F53S Disease NA 0.715 0.43 10 0.524 Q02750 Y130C Disease 0.926 0.843 0.00 60 0.926 Q02763 A226V Polymorphism 0.229 0.166 0.22 21 0.098 Q02763 A724T Polymorphism 0.135 0.333 0.26 5 0.147 Q02763 I148T Polymorphism NA 0.138 0.20 30 0.088 Q02763 R849W Disease 0.792 0.649 0.01 36 0.757 Q02763 T391I Polymorphism 0.618 0.257 0.04 50 0.585 Q02763 V486I Polymorphism 0.144 0.139 0.21 28 0.128 Q02763 V600L Polymorphism NA 0.375 0.36 -3 0.259 Q02763 V676I Polymorphism 0.153 0.217 0.21 16 0.205 Q02763 Y897S Disease 0.667 0.349 0.41 1 0.303 Q02779 P168Q Polymorphism 0.713 0.567 0.05 20 0.754 Q02790 T436P Polymorphism NA 0.085 0.30 6 0.089 Q02809 A99T Polymorphism 0.310 0.040 0.42 -38 0.085 Q02809 E67D Polymorphism 0.137 0.127 0.58 5 0.126 Q02809 A667T Disease 0.600 0.862 0.01 42 0.815 Q02809 G678R Disease 0.911 0.931 0.00 67 0.943 Q02809 H706R Disease 0.816 0.790 0.07 61 0.921 Q02809 W446G Disease 0.880 0.920 0.00 60 0.920 Q02809 W612C Disease 0.915 0.848 0.00 66 0.931 Q02817 L58P Polymorphism 0.761 0.466 0.29 2 0.572 Q02817 G832S Polymorphism 0.969 0.787 0.00 -14 0.877 Q02817 V116M Polymorphism 0.250 0.211 0.21 8 0.256 Q02817 I2154T Polymorphism NA 0.206 1.00 34 0.073 Q02817 P1689L Polymorphism NA 0.206 0.18 18 0.319 Q02817 Q2653L Polymorphism NA 0.238 0.44 45 0.390 Q02817 Q2653P Polymorphism NA 0.254 0.38 39 0.261 Q02817 S1619R Polymorphism NA 0.201 0.71 25 0.333 Q02817 T2524P Polymorphism NA 0.271 0.04 53 0.410 Q02818 R399Q Polymorphism 0.105 0.106 0.31 15 0.077 Q02833 P89A Polymorphism 0.768 0.598 0.32 -8 0.703 Q02833 R156Q Polymorphism 0.067 0.036 0.48 -27 0.048 Q02846 A52S Disease NA 0.261 0.77 10 0.344 Q02846 A328V Polymorphism NA 0.205 0.67 21 0.260 Q02846 A362S Disease NA 0.258 0.69 -16 0.192 Q02846 A693E Polymorphism 0.292 0.389 0.76 -4 0.231 Q02846 C105Y Disease NA 0.937 0.01 46 0.860 Q02846 E837D Disease 0.429 0.281 0.00 3 0.397 Q02846 F565S Disease NA 0.399 0.02 26 0.485 Q02846 I573V Disease NA 0.117 0.34 13 0.197 Q02846 L325P Disease NA 0.609 0.13 39 0.758 Q02846 L782H Polymorphism 0.105 0.389 0.03 -8 0.198 Q02846 L954P Disease 0.834 0.864 0.00 57 0.923 Q02846 P701S Disease 0.176 0.189 0.40 -3 0.207 Q02846 P858S Disease 0.999 0.877 0.00 44 0.903 Q02846 R722W Polymorphism 0.672 0.458 0.02 35 0.665 Q02846 R838C Disease 0.888 0.752 0.00 60 0.926 Q02846 R838H Disease 0.752 0.373 0.00 43 0.690 Q02878 K237E Polymorphism 0.183 0.500 0.61 0 0.294 Q02928 N226S Polymorphism 0.169 0.158 0.72 -46 0.115 Q02952 K216Q Polymorphism 0.065 0.089 0.53 -45 0.053 Q02952 E1355K Polymorphism 0.077 0.170 0.27 35 0.139 Q02952 E1600D Polymorphism 0.220 0.027 0.26 -35 0.012 Q02952 R1296L Polymorphism 0.418 0.149 0.31 18 0.113 Q02952 V1096I Polymorphism NA 0.036 0.46 10 0.029 Q02962 G76S Disease 0.878 0.876 0.00 49 0.919 Q02962 A334V Polymorphism 0.218 0.210 0.39 32 0.260 Q03013 S2P Polymorphism 0.098 0.483 1.00 -83 0.198 Q03013 L208V Polymorphism 0.089 0.278 0.52 -35 0.188 Q03013 V212M Polymorphism 0.113 0.064 0.62 -42 0.061 Q03013 Y209F Polymorphism 0.126 0.209 0.78 -36 0.145 Q03113 F242L Polymorphism 0.981 0.894 0.00 55 0.926 Q03113 Y330H Polymorphism 0.424 0.857 0.02 54 0.854 Q03154 E233D Disease 0.467 0.509 0.58 33 0.484 Q03154 R197W Disease 0.837 0.881 0.02 22 0.862 Q03154 R353C Disease 0.936 0.935 0.08 62 0.945 Q03154 R393H Disease 0.671 0.821 0.13 -8 0.781 Q03164 E502K Polymorphism NA 0.181 0.01 31 0.293 Q03164 P2354R Polymorphism NA 0.184 0.00 36 0.214 Q03164 S3773A Polymorphism NA 0.202 0.03 22 0.326 Q03167 S14N Polymorphism 0.347 0.163 0.00 -32 0.071 Q03167 F351I Polymorphism 0.454 0.603 0.05 -9 0.388 Q03167 W163L Polymorphism 0.530 0.831 0.00 36 0.830 Q03169 T565I Polymorphism 0.078 0.233 0.19 18 0.192 Q03169 T580M Polymorphism 0.099 0.100 0.18 -23 0.143 Q03252 A407T Disease NA 0.089 0.67 -50 0.138 Q03252 R215Q Disease 0.601 0.179 0.04 -18 0.269 Q03393 D96N Disease 0.640 0.722 0.10 43 0.846 Q03393 E35G Disease 0.397 0.553 0.08 41 0.745 Q03393 L26F Disease 0.762 0.718 0.02 65 0.906 Q03393 N36K Disease 0.656 0.940 0.32 43 0.861 Q03393 N47D Disease 0.619 0.694 0.29 47 0.863 Q03393 N52S Disease 0.288 0.916 0.67 13 0.508 Q03393 P87L Disease 0.211 0.124 0.20 -31 0.228 Q03393 P87S Disease 0.260 0.100 0.40 -16 0.224 Q03393 R16C Disease 0.765 0.868 0.00 52 0.894 Q03393 R25G Disease 0.644 0.790 0.02 48 0.862 Q03393 R25Q Disease 0.491 0.777 0.04 23 0.705 Q03393 T67M Disease 0.749 0.757 0.12 42 0.853 Q03393 V56M Disease 0.616 0.306 0.07 5 0.574 Q03393 V70D Disease 0.873 0.848 0.00 62 0.931 Q03393 V97M Disease 0.719 0.569 0.02 27 0.780 Q03393 Y99C Disease 0.820 0.516 0.16 24 0.773 Q03393 D116G Disease 0.659 0.689 0.04 0 0.745 Q03393 D136G Disease 0.580 0.519 0.30 4 0.539 Q03393 D136V Disease 0.617 0.457 0.21 8 0.583 Q03393 F100V Disease 0.439 0.916 0.17 44 0.834 Q03393 I114V Disease 0.427 0.582 0.07 6 0.484 Q03393 K129E Disease 0.255 0.370 1.00 -21 0.265 Q03393 T106M Disease 0.962 0.869 0.00 62 0.943 Q03393 V124L Disease 0.177 0.128 0.36 -43 0.106 Q03395 G75D Polymorphism NA 0.453 0.04 45 0.607 Q03395 P60T Polymorphism NA 0.103 0.86 25 0.080 Q03395 G118A Polymorphism 0.145 0.273 1.00 -40 0.167 Q03395 R229H Polymorphism 0.264 0.122 0.11 -3 0.057 Q03403 R3W Polymorphism 0.583 0.067 0.19 -15 0.033 Q03405 E55G Polymorphism 0.428 0.267 0.01 45 0.420 Q03405 T86A Polymorphism 0.182 0.142 0.26 41 0.146 Q03405 L317P Polymorphism 0.711 0.453 0.01 37 0.611 Q03405 N281K Polymorphism 0.108 0.111 0.29 20 0.076 Q03405 R105Q Polymorphism 0.582 0.393 0.13 -7 0.382 Q03426 H20N Disease NA 0.928 0.00 67 0.935 Q03426 H20P Disease NA 0.976 0.00 65 0.914 Q03426 H20Q Disease NA 0.940 0.00 63 0.935 Q03426 L39P Disease NA 0.972 0.03 -35 0.775 Q03426 S52N Polymorphism NA 0.254 0.52 -3 0.247 Q03426 A148T Disease 0.337 0.600 0.35 9 0.482 Q03426 A334T Disease 0.639 0.873 0.00 55 0.826 Q03426 G171R Disease 0.103 0.355 0.63 36 0.301 Q03426 G202R Disease 0.925 0.939 0.00 71 0.954 Q03426 G211E Disease 0.948 0.958 0.00 66 0.961 Q03426 G309S Disease 0.731 0.813 0.00 58 0.908 Q03426 G326R Disease 0.158 0.810 0.62 56 0.399 Q03426 G376V Disease 0.993 0.901 0.00 61 0.971 Q03426 I268T Disease 0.681 0.500 0.03 19 0.742 Q03426 L264F Disease 0.543 0.329 0.02 1 0.601 Q03426 L265P Disease 0.732 0.928 0.02 53 0.902 Q03426 L265R Disease 0.658 0.869 0.03 23 0.810 Q03426 N301T Disease 0.684 0.871 0.00 58 0.906 Q03426 P167L Disease 0.626 0.618 0.12 18 0.556 Q03426 R215Q Disease 0.362 0.161 0.39 40 0.276 Q03426 S135L Disease 0.707 0.946 0.00 53 0.784 Q03426 S150L Disease 0.581 0.398 0.10 6 0.622 Q03426 T243I Disease 0.913 0.943 0.00 -12 0.904 Q03426 V132I Disease 0.297 0.114 0.31 9 0.218 Q03426 V250I Disease 0.498 0.848 0.00 -3 0.620 Q03426 V310M Disease 0.790 0.914 0.00 60 0.930 Q03426 V377I Disease 0.251 0.333 0.27 -11 0.294 Q03431 H223R Disease 0.996 0.891 0.00 67 0.957 Q03431 I458R Disease 0.659 0.800 0.00 50 0.896 Q03431 P132L Disease 0.433 0.849 0.00 56 0.852 Q03431 R150C Disease 0.675 0.683 0.05 26 0.700 Q03431 T410P Disease 0.972 0.850 0.00 53 0.945 Q03431 T410R Disease 0.978 0.860 0.00 54 0.948 Q03468 D425A Polymorphism 0.132 0.202 0.24 37 0.249 Q03468 G446D Polymorphism NA 0.104 0.09 43 0.082 Q03468 R670W Disease 0.905 0.941 0.00 60 0.934 Q03468 V957G Disease 0.674 0.932 0.01 53 0.925 Q03468 W851R Disease 0.786 0.621 0.03 61 0.730 Q03468 D1355E Polymorphism NA 0.113 NA 11 0.125 Q03468 G1322V Polymorphism NA 0.323 NA 46 0.404 Q03468 G1410R Polymorphism NA 0.138 NA 45 0.149 Q03468 M1097V Polymorphism NA 0.058 0.02 -10 0.089 Q03468 P1042L Disease NA 0.139 0.02 3 0.161 Q03468 Q1413R Polymorphism NA 0.069 NA 22 0.116 Q03468 R1213G Polymorphism NA 0.116 NA 30 0.127 Q03468 R1230P Polymorphism NA 0.260 NA 40 0.226 Q03468 T1220I Polymorphism NA 0.126 NA -3 0.134 Q03468 T1441I Polymorphism NA 0.122 NA 17 0.073 Q03468 Y1002C Polymorphism 0.396 0.454 0.05 23 0.533 Q03518 P67S Polymorphism NA 0.211 0.00 32 0.172 Q03518 D697G Polymorphism 0.345 0.413 1.00 -15 0.106 Q03518 G479C Polymorphism 0.711 0.380 0.18 -13 0.582 Q03518 I393V Polymorphism 0.085 0.380 0.97 -51 0.169 Q03518 R708Q Polymorphism 0.369 0.796 0.02 45 0.766 Q03518 V578I Polymorphism NA 0.069 0.42 -32 0.128 Q03519 R56K Polymorphism NA 0.188 0.74 -5 0.172 Q03519 A374T Polymorphism 0.389 0.506 0.60 48 0.540 Q03519 A513S Polymorphism 0.386 0.552 0.45 -23 0.270 Q03519 R651C Polymorphism 0.128 0.664 0.19 -5 0.209 Q03519 T665A Polymorphism 0.259 0.824 0.13 60 0.824 Q03519 V379I Polymorphism 0.094 0.092 0.45 -43 0.111 Q03519 V467I Polymorphism 0.168 0.161 0.18 -35 0.151 Q03591 A296V Polymorphism 0.443 0.115 0.95 5 0.094 Q03591 H157Y Polymorphism NA 0.152 0.94 5 0.109 Q03591 L159V Polymorphism 0.160 0.181 0.51 32 0.151 Q03692 G18E Disease 0.129 0.521 0.15 56 0.255 Q03692 G18R Disease 0.162 0.493 0.12 58 0.590 Q03692 C591R Disease NA 0.787 0.01 46 0.792 Q03692 D648G Disease 0.626 0.826 0.00 12 0.727 Q03692 G595E Disease NA 0.721 0.00 72 0.719 Q03692 G595R Disease NA 0.794 0.00 72 0.887 Q03692 G618V Disease 0.698 0.377 0.01 66 0.904 Q03692 L614P Disease 0.838 0.740 0.00 -3 0.832 Q03692 L644R Disease 0.780 0.846 0.00 63 0.905 Q03692 N617K Disease 0.570 0.500 0.34 26 0.571 Q03692 Q653P Disease 0.739 0.555 0.02 38 0.761 Q03692 S600P Disease 0.579 0.820 0.00 -2 0.703 Q03692 S671P Disease 0.678 0.741 0.12 27 0.831 Q03692 V603M Polymorphism 0.404 0.355 0.01 -14 0.387 Q03692 W651R Disease 0.798 0.795 0.00 32 0.846 Q03692 Y582D Disease NA 0.788 0.00 31 0.699 Q03692 Y597C Disease 0.880 0.891 0.00 41 0.848 Q03692 Y597H Disease 0.678 0.727 0.00 35 0.801 Q03692 Y598D Disease 0.801 0.642 0.02 53 0.803 Q03701 P15S Polymorphism NA 0.248 NA 18 0.155 Q03701 K303R Polymorphism 0.370 0.645 0.00 -13 0.537 Q03923 K60T Polymorphism 0.548 0.417 0.18 20 0.616 Q03923 G184R Polymorphism 0.437 0.332 0.47 14 0.066 Q03924 K112N Polymorphism 0.318 0.310 0.61 -14 0.270 Q04323 L56F Polymorphism 0.198 0.185 0.17 6 0.252 Q04446 F257L Disease 0.698 0.783 0.01 61 0.897 Q04446 H545R Disease 0.896 0.801 0.05 64 0.928 Q04446 H628R Disease 0.686 0.829 0.09 70 0.907 Q04446 L224P Disease 0.927 0.927 0.11 61 0.951 Q04446 R190G Polymorphism 0.436 0.510 0.07 37 0.540 Q04446 R515C Disease 0.966 0.952 0.00 69 0.949 Q04446 R515H Disease 0.922 0.908 0.00 57 0.925 Q04446 R524Q Disease 0.630 0.617 0.09 53 0.648 Q04446 Y329S Disease 0.898 0.533 0.00 62 0.921 Q04609 Y75H Polymorphism 0.212 0.369 0.05 -27 0.154 Q04609 V627L Polymorphism 0.185 0.211 0.49 19 0.242 Q04656 A629P Disease NA 0.902 0.18 10 0.497 Q04656 G727R Disease 0.901 0.794 0.08 35 0.792 Q04656 G853R Disease 0.989 0.857 0.00 66 0.909 Q04656 G860V Disease 0.989 0.877 0.00 54 0.909 Q04656 G876E Disease 0.996 0.946 0.00 72 0.922 Q04656 G876R Disease 0.996 0.915 0.00 76 0.923 Q04656 I669T Polymorphism NA 0.426 0.14 -7 0.319 Q04656 L706R Disease 0.151 0.536 0.01 58 0.618 Q04656 L873R Disease 0.862 0.869 0.01 49 0.885 Q04656 Q924R Disease 0.963 0.920 0.00 39 0.854 Q04656 R703H Polymorphism 0.136 0.150 0.66 -30 0.105 Q04656 R844H Disease 0.856 0.281 0.19 7 0.580 Q04656 S637L Disease NA 0.272 0.29 -2 0.347 Q04656 V767L Polymorphism 0.181 0.584 0.66 -14 0.183 Q04656 A1007V Disease 0.957 0.839 0.01 37 0.861 Q04656 A1325V Disease 0.965 0.886 0.02 45 0.894 Q04656 A1362V Disease 0.890 0.846 0.02 35 0.862 Q04656 C1000R Disease 0.989 0.839 0.00 71 0.903 Q04656 D1044G Disease 0.999 0.814 0.00 65 0.921 Q04656 D1305A Disease 0.993 0.878 0.00 68 0.929 Q04656 G1015D Disease 0.684 0.941 0.01 72 0.912 Q04656 G1019D Disease 0.707 0.955 0.01 70 0.931 Q04656 G1118D Disease 0.941 0.926 0.00 69 0.939 Q04656 G1255R Disease 0.995 0.921 0.00 74 0.933 Q04656 G1300E Disease 0.999 0.958 0.00 70 0.933 Q04656 G1302R Disease 0.996 0.928 0.00 78 0.932 Q04656 G1302V Disease 0.997 0.933 0.00 69 0.934 Q04656 G1315R Disease 0.904 0.935 0.00 69 0.919 Q04656 G1369R Disease 0.904 0.906 0.16 49 0.900 Q04656 I1345F Disease 0.570 0.604 0.12 21 0.522 Q04656 I1464V Polymorphism NA 0.169 0.21 16 0.132 Q04656 K1282E Disease 0.992 0.946 0.00 61 0.929 Q04656 L1006P Disease 0.984 0.826 0.00 37 0.892 Q04656 L1100P Disease 0.860 0.794 0.23 22 0.830 Q04656 N1304K Disease 0.995 0.907 0.00 70 0.927 Q04656 S1344R Disease 0.690 0.642 0.03 40 0.806 Q04656 S1397F Disease 0.972 0.902 0.00 53 0.937 Q04671 G27R Disease NA 0.067 0.10 27 0.033 Q04671 R10W Disease NA 0.119 0.03 44 0.140 Q04671 S86R Disease NA 0.141 0.00 29 0.068 Q04671 A334V Disease 0.757 0.871 0.03 27 0.704 Q04671 A336V Polymorphism 0.067 0.280 0.07 -50 0.192 Q04671 A368V Disease 0.657 0.281 0.17 -2 0.551 Q04671 A481T Disease 0.316 0.925 0.28 12 0.577 Q04671 A724P Disease 0.766 0.830 0.01 60 0.866 Q04671 A787V Disease 0.657 0.895 0.01 58 0.904 Q04671 C112F Disease NA 0.409 0.12 1 0.490 Q04671 F385I Disease 0.358 0.479 0.00 -19 0.484 Q04671 G775R Disease 0.962 0.962 0.00 63 0.954 Q04671 G795R Disease 0.872 0.946 0.01 71 0.866 Q04671 H549Q Disease 0.463 0.411 0.01 38 0.385 Q04671 H615R Polymorphism 0.396 0.231 0.01 27 0.350 Q04671 I473S Disease 0.484 0.611 0.00 42 0.556 Q04671 I617L Disease 0.359 0.802 0.03 0 0.557 Q04671 K614E Disease 0.321 0.551 0.01 34 0.539 Q04671 K614N Disease 0.403 0.661 0.01 29 0.560 Q04671 L440F Polymorphism 0.632 0.806 0.26 20 0.656 Q04671 L440H Polymorphism 0.904 0.850 0.03 51 0.930 Q04671 M394I Disease 0.487 0.835 1.00 30 0.800 Q04671 M395L Disease 0.658 0.939 0.29 31 0.860 Q04671 M446V Disease 0.109 0.187 0.43 -10 0.145 Q04671 N476D Disease 0.593 0.934 0.27 62 0.741 Q04671 N489D Disease 0.289 0.936 0.01 73 0.931 Q04671 P198L Disease NA 0.389 0.00 0 0.525 Q04671 P211L Disease NA 0.356 0.00 16 0.504 Q04671 P241R Polymorphism NA 0.167 0.00 25 0.230 Q04671 P743L Disease 0.853 0.920 0.00 51 0.911 Q04671 Q799H Disease 0.285 0.614 0.01 35 0.609 Q04671 R290G Disease NA 0.342 0.00 40 0.513 Q04671 R305W Polymorphism NA 0.162 0.00 56 0.341 Q04671 R419W Disease 0.826 0.758 0.02 34 0.862 Q04671 R560H Polymorphism 0.560 0.557 0.00 42 0.576 Q04671 R720C Disease 0.921 0.582 0.04 61 0.914 Q04671 S736L Disease 0.751 0.938 0.00 37 0.869 Q04671 T404M Disease 0.905 0.677 0.01 42 0.831 Q04671 T592I Disease 0.327 0.456 0.13 24 0.441 Q04671 V443I Disease 0.157 0.450 0.23 19 0.266 Q04671 W652R Disease 0.919 0.859 0.22 55 0.925 Q04671 W679C Disease 0.982 0.899 0.01 77 0.953 Q04671 W679R Disease 0.968 0.922 0.04 78 0.952 Q04671 Y827H Disease 0.749 0.793 0.05 55 0.868 Q04695 L95P Disease 0.991 0.949 0.00 54 0.935 Q04695 L95Q Disease 0.991 0.884 0.00 36 0.921 Q04695 L99P Disease 0.986 0.939 0.00 50 0.938 Q04695 M88T Disease 0.981 0.907 0.00 39 0.914 Q04695 N92D Disease 0.974 0.839 0.00 38 0.897 Q04695 N92H Disease 0.992 0.835 0.00 44 0.914 Q04695 N92S Disease 0.977 0.883 0.00 28 0.911 Q04695 R94C Disease 0.990 0.937 0.00 23 0.876 Q04695 R94H Disease 0.927 0.897 0.00 25 0.875 Q04695 R94P Disease 0.976 0.964 0.00 56 0.941 Q04695 Y98D Disease 0.991 0.839 0.00 57 0.939 Q04695 N109D Disease 0.967 0.770 0.00 42 0.898 Q04695 V102M Disease 0.998 0.911 0.00 42 0.920 Q04721 C444Y Disease 0.953 0.662 0.00 73 0.982 Q04721 V1667F Polymorphism NA 0.230 0.72 22 0.344 Q04756 A218S Polymorphism NA 0.210 0.40 -32 0.177 Q04756 F231L Polymorphism 0.090 0.116 0.68 7 0.087 Q04756 R509H Polymorphism NA 0.669 0.32 -1 0.421 Q04756 R644Q Polymorphism NA 0.206 0.28 -18 0.165 Q04759 D354N Polymorphism NA 0.374 0.49 -27 0.270 Q04759 P330L Polymorphism NA 0.132 0.63 14 0.153 Q04760 C19Y Polymorphism NA 0.310 0.06 21 0.397 Q04760 E111A Polymorphism 0.339 0.435 0.34 11 0.387 Q04771 A15G Polymorphism NA 0.188 0.27 5 0.110 Q04771 H47Q Polymorphism NA 0.146 0.29 29 0.196 Q04771 S41F Polymorphism NA 0.356 0.44 37 0.520 Q04771 G328E Disease 0.554 0.889 0.07 23 0.844 Q04771 G328R Disease 0.412 0.875 0.18 30 0.653 Q04771 G328W Disease 0.952 0.843 0.01 43 0.865 Q04771 G356D Disease 0.991 0.927 0.00 71 0.944 Q04771 Q207E Disease 0.356 0.246 1.00 3 0.313 Q04771 R202I Disease 0.798 0.649 0.03 43 0.812 Q04771 R206H Disease 0.640 0.608 0.08 33 0.696 Q04771 R375P Disease 0.833 0.829 0.01 31 0.828 Q04826 L9V Polymorphism 0.206 0.734 0.16 -51 0.428 Q04826 E87N Polymorphism 0.416 0.541 0.22 12 0.480 Q04826 S91F Polymorphism 0.275 0.561 0.66 -18 0.380 Q04826 V17L Polymorphism 0.352 0.167 1.00 -74 0.086 Q04826 E187L Polymorphism 0.399 0.457 0.49 25 0.415 Q04826 H137Y Polymorphism 0.504 0.109 1.00 3 0.074 Q04826 L119W Polymorphism 0.816 0.817 0.13 0 0.811 Q04826 N138D Polymorphism 0.304 0.285 0.23 -16 0.220 Q04826 R155S Polymorphism 0.255 0.762 0.77 0 0.502 Q04826 S121T Polymorphism 0.237 0.376 0.59 0 0.199 Q04826 V127L Polymorphism 0.305 0.714 0.45 -36 0.476 Q04826 V306I Polymorphism 0.201 0.068 1.00 -25 0.039 Q04826 W171L Polymorphism 0.452 0.785 0.02 47 0.763 Q04828 R170H Polymorphism 0.247 0.268 0.57 -14 0.221 Q04844 G13R Disease NA 0.311 0.35 15 0.391 Q04844 G18V Polymorphism NA 0.278 0.44 -41 0.257 Q04844 L98P Disease 0.696 0.945 0.00 53 0.909 Q04844 A431P Disease 0.528 0.858 0.01 51 0.889 Q04844 L241F Disease 0.863 0.563 0.00 19 0.764 Q04844 L289F Disease 0.863 0.768 0.00 23 0.850 Q04844 P141L Disease 0.969 0.929 0.00 48 0.913 Q04844 P265L Disease 0.969 0.940 0.00 48 0.915 Q04844 R167L Disease 0.460 0.604 0.05 57 0.752 Q04844 R331W Disease 0.985 0.717 0.00 72 0.942 Q04844 S163L Disease 0.442 0.264 0.00 2 0.398 Q04844 T284P Disease 0.504 0.947 0.00 56 0.912 Q04912 P95T Polymorphism NA 0.479 0.00 36 0.551 Q04912 R75S Polymorphism NA 0.294 0.01 31 0.493 Q04912 N440S Polymorphism NA 0.344 0.65 40 0.565 Q04912 R185C Polymorphism NA 0.231 0.01 33 0.409 Q04912 S434L Polymorphism NA 0.138 0.08 -10 0.097 Q04912 R1335G Polymorphism 0.257 0.382 0.07 8 0.237 Q04912 Y1360C Polymorphism 0.882 0.751 0.02 37 0.860 Q05066 S3L Disease NA 0.187 0.00 8 0.241 Q05066 F67V Disease 0.625 0.849 0.00 64 0.913 Q05066 G95E Disease 0.999 0.896 0.01 65 0.952 Q05066 G95R Disease 0.999 0.941 0.00 65 0.954 Q05066 I68T Disease 0.563 0.777 0.00 36 0.842 Q05066 I90M Disease 0.645 0.863 0.00 56 0.905 Q05066 M64I Disease 0.999 0.821 0.00 53 0.942 Q05066 M64R Disease 0.999 0.934 0.00 63 0.953 Q05066 M78T Disease 0.348 0.758 0.01 43 0.720 Q05066 N87Y Disease 0.997 0.899 0.00 60 0.954 Q05066 R62G Disease 0.998 0.900 0.00 60 0.955 Q05066 R76S Disease 0.521 0.899 0.01 45 0.885 Q05066 S18N Disease NA 0.132 0.12 8 0.125 Q05066 S91G Disease 0.997 0.779 0.00 51 0.940 Q05066 V60A Disease 0.579 0.725 0.01 41 0.831 Q05066 V60L Disease 0.437 0.873 0.01 38 0.863 Q05066 A113T Disease 0.578 0.837 0.00 38 0.870 Q05066 F109S Disease 0.789 0.851 0.00 49 0.898 Q05066 K106I Disease 0.990 0.701 0.00 61 0.941 Q05066 L101H Disease 0.898 0.860 0.00 66 0.929 Q05066 P108R Disease 0.999 0.818 0.02 41 0.898 Q05066 P125L Disease 0.999 0.846 0.00 39 0.920 Q05066 P131R Disease 0.988 0.822 0.00 45 0.920 Q05066 R133W Disease 0.998 0.811 0.00 52 0.941 Q05066 Y127C Disease 0.999 0.871 0.00 64 0.955 Q05066 Y127F Disease 0.994 0.822 0.01 55 0.948 Q05086 C44Y Polymorphism 0.675 0.894 NA 58 0.910 Q05086 S372P Polymorphism 0.468 0.430 NA 4 0.504 Q05086 V290G Polymorphism 0.224 0.554 NA 30 0.679 Q05193 D744N Polymorphism NA 0.713 0.28 18 0.525 Q05209 E706K Polymorphism NA 0.120 0.59 23 0.059 Q05209 T573A Polymorphism NA 0.056 0.66 -23 0.058 Q05329 G12R Polymorphism NA 0.267 0.00 61 0.356 Q05329 G232E Polymorphism NA 0.690 0.89 -27 0.406 Q05397 H292P Polymorphism 0.460 0.416 0.24 16 0.398 Q05397 H292Q Polymorphism 0.296 0.316 0.07 10 0.347 Q05397 D1030E Polymorphism NA 0.679 0.00 47 0.753 Q05469 A194V Polymorphism NA 0.086 NA -12 0.037 Q05469 N499H Polymorphism 0.377 0.079 0.00 33 0.159 Q05469 R217Q Polymorphism NA 0.099 NA -22 0.026 Q05469 R938S Polymorphism 0.178 0.179 0.18 34 0.138 Q05469 S177T Polymorphism NA 0.180 NA 7 0.120 Q05469 Y100H Polymorphism NA 0.133 NA 14 0.016 Q05481 F455I Polymorphism 0.878 0.303 1.00 2 0.015 Q05481 T896A Polymorphism NA 0.274 0.78 -25 0.204 Q05481 L1164V Polymorphism NA 0.088 0.06 16 0.085 Q05513 R49H Polymorphism NA 0.086 0.13 -11 0.111 Q05513 R84H Polymorphism NA 0.086 0.20 18 0.111 Q05586 I540M Polymorphism 0.309 0.603 0.01 36 0.549 Q05655 F375S Polymorphism 0.648 0.799 0.00 42 0.839 Q05655 M494V Polymorphism 0.668 0.685 0.01 47 0.844 Q05655 V593M Polymorphism 0.335 0.296 0.14 9 0.382 Q05707 V922I Polymorphism NA 0.088 0.04 37 0.197 Q05707 V1342L Polymorphism NA 0.510 0.02 -3 0.479 Q05823 I97L Polymorphism 0.221 0.161 0.66 -33 0.203 Q05823 R462Q Polymorphism NA 0.124 0.40 47 0.107 Q05823 S406F Polymorphism NA 0.127 0.01 53 0.186 Q05901 K451E Polymorphism 0.140 0.269 0.28 23 0.141 Q05932 S528T Polymorphism 0.352 0.090 0.50 -46 0.150 Q05952 R131W Polymorphism 0.891 0.377 0.00 55 0.608 Q05996 G36V Polymorphism 0.299 0.052 1.00 -36 0.007 Q05C16 M206V Polymorphism 0.195 0.051 0.90 27 0.026 Q05C16 T282A Polymorphism 0.212 0.096 0.28 43 0.079 Q05D60 E440G Polymorphism NA 0.194 0.04 21 0.244 Q05D60 E440Q Polymorphism NA 0.146 0.13 -14 0.072 Q05D60 S175F Polymorphism NA 0.111 0.03 24 0.234 Q06033 T340M Polymorphism NA 0.660 0.00 14 0.716 Q06124 T2I Disease NA 0.290 0.39 -15 0.381 Q06124 A72G Disease NA 0.797 0.33 48 0.655 Q06124 A72S Disease NA 0.765 0.39 45 0.606 Q06124 A72T Disease NA 0.616 0.38 27 0.586 Q06124 A72V Disease NA 0.576 0.49 49 0.719 Q06124 D61G Disease NA 0.657 0.44 46 0.539 Q06124 D61N Disease NA 0.528 0.77 28 0.458 Q06124 D61V Disease NA 0.546 0.08 39 0.736 Q06124 D61Y Disease NA 0.752 0.02 57 0.857 Q06124 E69K Disease NA 0.771 0.23 56 0.821 Q06124 E69Q Disease NA 0.667 0.14 51 0.602 Q06124 E76A Disease NA 0.627 0.08 31 0.729 Q06124 E76D Disease NA 0.475 0.14 27 0.353 Q06124 E76G Disease NA 0.735 0.04 36 0.639 Q06124 E76K Disease NA 0.715 0.26 52 0.806 Q06124 E76V Disease NA 0.729 0.03 45 0.825 Q06124 G60A Disease NA 0.538 0.76 38 0.496 Q06124 N58K Disease NA 0.655 0.95 49 0.558 Q06124 Q79P Disease NA 0.736 0.27 47 0.779 Q06124 Q79R Disease NA 0.463 0.39 39 0.495 Q06124 T42A Disease NA 0.235 0.38 28 0.302 Q06124 T73I Disease NA 0.734 0.40 46 0.825 Q06124 Y62D Disease NA 0.430 0.32 42 0.543 Q06124 Y63C Disease NA 0.914 0.03 47 0.855 Q06124 A465T Disease 0.961 0.695 0.00 56 0.925 Q06124 D106A Disease NA 0.614 0.81 45 0.566 Q06124 E139D Disease NA 0.407 0.48 11 0.462 Q06124 F285L Disease 0.285 0.754 0.05 38 0.400 Q06124 F285S Disease 0.542 0.798 0.01 51 0.529 Q06124 G468A Disease 0.998 0.804 0.00 64 0.909 Q06124 G507A Disease 0.688 0.458 0.51 16 0.568 Q06124 G507R Disease 0.866 0.531 0.33 53 0.806 Q06124 I282V Disease 0.236 0.652 0.47 17 0.332 Q06124 I309V Disease 0.127 0.270 0.01 23 0.120 Q06124 L564F Disease 0.146 0.171 0.07 2 0.207 Q06124 M508V Disease 0.156 0.657 0.01 55 0.322 Q06124 N308D Disease 0.531 0.685 0.01 47 0.808 Q06124 N308S Disease 0.574 0.581 0.43 30 0.497 Q06124 Q256R Disease 0.326 0.200 0.97 39 0.256 Q06124 Q510P Disease 0.989 0.909 0.00 57 0.899 Q06124 Q510R Disease 0.982 0.863 0.00 71 0.915 Q06124 Q514P Disease 0.998 0.928 0.00 71 0.942 Q06124 R502L Disease 0.993 0.857 0.00 63 0.926 Q06124 R502W Disease 0.997 0.910 0.00 69 0.927 Q06124 R505K Disease 0.475 0.771 0.00 76 0.666 Q06124 S506T Disease 0.506 0.429 0.59 3 0.471 Q06124 T415M Disease 0.382 0.247 0.06 -10 0.372 Q06124 T472M Disease 0.861 0.872 0.02 35 0.798 Q06124 Y279C Disease 0.979 0.904 0.00 57 0.974 Q06124 Y279S Disease 0.951 0.871 0.00 48 0.903 Q06187 F25S Disease NA 0.480 0.00 34 0.635 Q06187 I61N Disease 0.210 0.530 0.00 53 0.692 Q06187 K12R Disease NA 0.409 0.00 47 0.622 Q06187 K19E Disease NA 0.272 0.01 33 0.392 Q06187 K27R Disease NA 0.153 0.42 30 0.234 Q06187 L11P Disease NA 0.423 0.00 42 0.610 Q06187 R28C Disease NA 0.765 0.00 67 0.862 Q06187 R28H Disease NA 0.744 0.00 69 0.861 Q06187 R28P Disease NA 0.803 0.00 63 0.883 Q06187 R82K Polymorphism NA 0.061 0.92 16 0.029 Q06187 S14F Disease NA 0.636 0.00 55 0.715 Q06187 T33P Disease NA 0.635 0.11 46 0.722 Q06187 V64D Disease 0.460 0.563 0.00 63 0.822 Q06187 V64F Disease 0.317 0.426 0.00 53 0.675 Q06187 Y39S Disease 0.327 0.864 0.00 59 0.826 Q06187 Y40C Disease 0.607 0.687 0.00 59 0.839 Q06187 Y40N Disease 0.392 0.593 0.00 51 0.721 Q06187 A508D Disease 0.450 0.800 0.00 52 0.856 Q06187 A523E Disease 0.796 0.874 0.01 45 0.876 Q06187 A582V Disease 0.388 0.656 0.00 38 0.752 Q06187 A607D Disease 0.390 0.630 0.01 35 0.522 Q06187 A622P Disease 0.741 0.886 0.00 28 0.868 Q06187 C154S Disease 0.523 0.938 0.03 63 0.889 Q06187 C155G Disease 0.603 0.928 0.05 74 0.930 Q06187 C155R Disease 0.764 0.948 0.00 83 0.950 Q06187 C502F Disease 0.901 0.771 0.01 31 0.839 Q06187 C502W Disease 0.962 0.756 0.00 42 0.848 Q06187 C506R Disease 0.500 0.816 0.01 47 0.856 Q06187 C506Y Disease 0.617 0.851 0.00 35 0.863 Q06187 C633Y Disease 0.904 0.949 0.00 64 0.920 Q06187 D308E Disease 0.164 0.138 1.00 -16 0.096 Q06187 D521G Disease 0.979 0.860 0.00 72 0.922 Q06187 D521H Disease 0.992 0.888 0.00 79 0.921 Q06187 D521N Disease 0.980 0.871 0.00 72 0.895 Q06187 E445D Disease 0.955 0.884 0.00 64 0.907 Q06187 E567K Disease 0.964 0.820 0.00 70 0.918 Q06187 E589D Disease 0.246 0.848 0.00 60 0.883 Q06187 E589G Disease 0.436 0.802 0.00 59 0.871 Q06187 E589K Disease 0.300 0.935 0.00 70 0.930 Q06187 F559S Disease 0.829 0.462 0.08 47 0.702 Q06187 F583S Disease 0.582 0.762 0.00 56 0.856 Q06187 F644L Disease 0.311 0.877 0.04 44 0.678 Q06187 F644S Disease 0.623 0.895 0.00 49 0.896 Q06187 G302E Disease 0.972 0.955 0.00 69 0.951 Q06187 G302R Disease 0.978 0.963 0.00 71 0.951 Q06187 G414R Disease 0.881 0.916 0.00 75 0.918 Q06187 G462D Disease 0.842 0.901 0.00 72 0.916 Q06187 G462V Disease 0.870 0.875 0.00 62 0.916 Q06187 G594E Disease 0.983 0.916 0.00 57 0.926 Q06187 G594R Disease 0.985 0.864 0.00 56 0.924 Q06187 G613D Disease 0.856 0.891 0.03 39 0.743 Q06187 H362Q Disease 0.811 0.656 0.01 55 0.790 Q06187 H364P Disease 0.661 0.788 0.12 51 0.875 Q06187 I370M Disease 0.380 0.249 0.07 -15 0.358 Q06187 I429N Disease 0.675 0.846 0.00 18 0.847 Q06187 K430E Disease 0.999 0.954 0.00 64 0.930 Q06187 K430R Disease 0.999 0.871 0.00 39 0.899 Q06187 L295P Disease 0.895 0.876 0.00 64 0.941 Q06187 L358F Disease 0.424 0.834 0.04 45 0.738 Q06187 L369F Disease 0.313 0.701 0.01 46 0.739 Q06187 L408P Disease 0.742 0.945 0.00 55 0.925 Q06187 L512P Disease 0.586 0.918 0.00 62 0.914 Q06187 L512Q Disease 0.495 0.902 0.00 46 0.882 Q06187 L518R Disease 0.662 0.734 0.00 46 0.843 Q06187 L542P Disease 0.765 0.858 0.00 43 0.855 Q06187 L647P Disease 0.898 0.943 0.00 57 0.938 Q06187 L652P Disease 0.447 0.817 0.10 17 0.794 Q06187 M477R Disease 0.474 0.886 0.00 62 0.900 Q06187 M509I Disease 0.894 0.816 0.00 50 0.904 Q06187 M509V Disease 0.905 0.881 0.00 51 0.907 Q06187 M587L Disease 0.069 0.305 1.00 -1 0.200 Q06187 M630I Polymorphism 0.538 0.851 0.02 36 0.588 Q06187 M630K Disease 0.796 0.939 0.00 58 0.923 Q06187 M630T Disease 0.746 0.918 0.00 47 0.883 Q06187 N365Y Disease 0.857 0.666 0.01 51 0.869 Q06187 N526K Disease 0.987 0.881 0.00 69 0.924 Q06187 P619A Disease 0.772 0.741 0.01 49 0.889 Q06187 P619S Disease 0.802 0.836 0.02 45 0.876 Q06187 P619T Disease 0.841 0.854 0.00 39 0.817 Q06187 Q127H Disease 0.346 0.176 0.05 13 0.283 Q06187 R288Q Disease 0.918 0.917 0.00 62 0.943 Q06187 R288W Disease 0.985 0.939 0.00 67 0.951 Q06187 R307G Disease 0.239 0.862 0.00 65 0.896 Q06187 R307T Disease 0.360 0.880 0.00 69 0.899 Q06187 R372G Disease 0.783 0.521 0.01 43 0.772 Q06187 R520Q Disease 0.732 0.901 0.00 69 0.910 Q06187 R525G Disease 0.801 0.876 0.01 48 0.883 Q06187 R525P Disease 0.864 0.957 0.01 50 0.911 Q06187 R525Q Disease 0.732 0.916 0.04 47 0.882 Q06187 R544G Disease 0.487 0.843 0.00 57 0.890 Q06187 R544K Disease 0.260 0.821 0.16 14 0.410 Q06187 R562P Disease 0.578 0.887 0.00 49 0.881 Q06187 R562W Disease 0.820 0.838 0.00 54 0.919 Q06187 R641C Disease 0.999 0.917 0.00 71 0.948 Q06187 R641H Disease 0.999 0.872 0.00 68 0.949 Q06187 S115F Disease 0.431 0.253 0.00 31 0.397 Q06187 S366F Disease 0.601 0.705 0.01 47 0.847 Q06187 S578Y Disease 0.506 0.845 0.00 55 0.888 Q06187 S592P Disease 0.484 0.843 0.00 40 0.852 Q06187 T117P Disease 0.346 0.177 0.03 25 0.304 Q06187 T184P Disease 0.346 0.148 0.28 -2 0.230 Q06187 V113D Disease 0.460 0.536 0.00 58 0.747 Q06187 V319A Disease 0.291 0.297 0.00 52 0.544 Q06187 V535F Disease 0.755 0.873 0.01 40 0.858 Q06187 V626G Disease 0.691 0.354 0.00 42 0.650 Q06187 W563L Disease 0.978 0.767 0.00 63 0.917 Q06187 W581R Disease 0.986 0.899 0.00 68 0.921 Q06187 Y334S Disease 0.944 0.704 0.00 47 0.895 Q06187 Y361C Disease 0.920 0.856 0.01 33 0.886 Q06187 Y418H Disease 0.442 0.500 0.51 -29 0.412 Q06187 Y476D Disease 0.721 0.750 0.00 61 0.890 Q06187 Y598C Disease 0.827 0.872 0.00 64 0.915 Q06190 D745N Polymorphism NA 0.084 0.18 -14 0.135 Q06190 P481A Polymorphism 0.732 0.114 NA 7 0.059 Q06265 I366V Polymorphism 0.106 0.098 1.00 -34 0.035 Q06265 S425T Polymorphism NA 0.184 0.00 1 0.072 Q06278 H1297R Polymorphism 0.118 0.177 0.43 -31 0.119 Q06323 S55N Polymorphism 0.501 0.431 0.15 7 0.450 Q06323 T244K Polymorphism 0.230 0.220 0.25 3 0.297 Q06330 D334H Polymorphism 0.325 0.477 0.01 48 0.549 Q06330 K291E Polymorphism 0.156 0.492 0.19 44 0.318 Q06330 M296K Polymorphism 0.312 0.783 0.32 49 0.839 Q06330 P425S Polymorphism 0.140 0.659 0.00 34 0.457 Q06330 R419Q Polymorphism 0.320 0.480 0.04 37 0.408 Q06418 A831T Polymorphism NA 0.139 0.14 8 0.196 Q06418 R824G Polymorphism NA 0.171 0.36 22 0.118 Q06432 G196S Polymorphism NA 0.626 0.27 48 0.642 Q06481 D632N Polymorphism 0.056 0.250 0.61 -15 0.174 Q06495 A48F Disease 0.575 0.193 0.04 -6 0.329 Q06495 V147M Disease 0.415 0.747 0.02 -1 0.571 Q06520 A63P Polymorphism 0.163 0.720 0.27 -35 0.224 Q06520 A261T Polymorphism 0.376 0.832 0.12 -1 0.580 Q06546 A291V Polymorphism NA 0.072 0.37 11 0.128 Q06546 E345K Polymorphism 0.379 0.808 0.31 -6 0.502 Q06609 R150Q Disease 0.093 0.308 0.61 -32 0.138 Q06643 G70E Polymorphism 0.555 0.119 0.28 37 0.062 Q06643 L87F Polymorphism 0.390 0.060 0.01 -28 0.101 Q06643 S84R Polymorphism 0.256 0.242 0.22 36 0.130 Q06643 A111P Polymorphism 0.574 0.511 0.01 54 0.522 Q06710 C57Y Disease 0.963 0.933 0.00 56 0.954 Q06710 L62R Disease 0.930 0.935 0.00 58 0.946 Q06710 Q40P Disease 0.431 0.667 0.20 41 0.780 Q06710 R31H Disease 0.914 0.954 0.00 61 0.942 Q06710 F329L Polymorphism NA 0.111 1.00 29 0.095 Q06730 D804H Polymorphism NA 0.136 0.33 20 0.055 Q06730 G614R Polymorphism 0.117 0.571 0.07 65 0.320 Q06730 Q549E Polymorphism 0.139 0.226 1.00 -27 0.020 Q06732 H356R Polymorphism 0.123 0.530 0.02 10 0.281 Q06732 R145C Polymorphism 0.486 0.648 0.48 13 0.348 Q06787 A145S Polymorphism 0.160 0.072 1.00 -48 0.031 Q06787 I304N Disease 0.891 0.962 0.00 55 0.943 Q07000 A73E Polymorphism 0.554 0.160 0.07 17 0.355 Q07000 G40S Polymorphism 0.549 0.867 0.11 34 0.709 Q07000 N90K Polymorphism 0.213 0.356 0.87 -20 0.277 Q07000 T97A Polymorphism 0.412 0.199 0.20 -11 0.302 Q07000 V76M Polymorphism 0.313 0.081 0.51 -42 0.135 Q07000 A182V Polymorphism 0.530 0.592 0.02 11 0.528 Q07000 E201K Polymorphism 0.396 0.711 0.69 14 0.515 Q07000 L140S Polymorphism 0.371 0.487 0.16 25 0.364 Q07001 E80K Disease 0.330 0.634 0.53 -3 0.351 Q07001 F95L Disease 0.363 0.863 0.02 46 0.825 Q07001 P271Q Disease 0.977 0.888 0.00 57 0.932 Q07001 Q288E Disease 0.821 0.798 0.03 19 0.861 Q07001 S289F Disease 0.745 0.899 0.00 14 0.840 Q07002 G46S Polymorphism NA 0.440 0.06 -7 0.402 Q07002 G65R Polymorphism 0.052 0.118 0.12 45 0.178 Q07002 T164M Polymorphism 0.120 0.820 0.00 44 0.711 Q07065 A348T Polymorphism NA 0.027 0.55 -39 0.054 Q07092 Q27H Polymorphism NA 0.085 NA 22 0.094 Q07092 T62K Polymorphism NA 0.313 NA -23 0.226 Q07092 R418Q Polymorphism NA 0.361 0.60 40 0.274 Q07157 I790V Polymorphism 0.063 0.590 0.06 28 0.189 Q07157 H1110R Polymorphism 0.126 0.091 0.00 44 0.151 Q07157 N1605S Polymorphism NA 0.206 0.00 32 0.425 Q07283 L790M Polymorphism NA 0.089 0.20 -12 0.052 Q07283 R552S Polymorphism NA 0.067 0.54 27 0.061 Q07283 L1258V Polymorphism NA 0.026 0.93 33 0.033 Q07507 V201I Polymorphism 0.144 0.118 0.00 33 0.153 Q07617 E331K Polymorphism NA 0.030 0.55 -12 0.086 Q07617 H827Y Polymorphism NA 0.160 0.04 7 0.222 Q07617 M777T Polymorphism NA 0.059 0.11 -7 0.023 Q07699 C121W Disease 0.950 0.949 0.00 71 0.962 Q07812 G39R Polymorphism 0.210 0.120 0.08 25 0.113 Q07820 A227V Polymorphism 0.552 0.207 0.25 10 0.179 Q07820 E173D Polymorphism 0.074 0.104 0.25 -14 0.067 Q07820 M231L Polymorphism 0.176 0.287 0.33 25 0.216 Q07837 E268K Disease 0.645 0.488 0.02 25 0.610 Q07837 E482K Disease 0.902 0.892 0.03 70 0.909 Q07837 F599S Disease 0.657 0.841 0.27 9 0.802 Q07837 F648S Disease 0.920 0.718 0.03 -8 0.784 Q07837 G398R Disease 0.530 0.755 0.61 65 0.631 Q07837 G481V Disease 0.993 0.905 0.00 58 0.932 Q07837 G600E Disease 0.551 0.755 0.03 36 0.694 Q07837 L678P Disease NA 0.557 NA 66 0.805 Q07837 M467K Disease 0.876 0.778 0.11 55 0.798 Q07837 M467T Disease 0.405 0.388 1.00 14 0.316 Q07837 N253K Disease 0.701 0.871 0.02 58 0.902 Q07837 P128Q Disease 0.979 0.743 0.00 47 0.887 Q07837 P508A Disease 0.820 0.797 0.00 62 0.915 Q07837 P615T Disease 0.366 0.787 0.71 -25 0.489 Q07837 Q510R Disease 0.892 0.905 0.02 33 0.865 Q07837 R181Q Disease 0.535 0.251 0.49 4 0.541 Q07837 R362C Disease 0.750 0.563 0.15 44 0.795 Q07837 R362H Disease 0.373 0.391 0.50 0 0.294 Q07837 R365W Disease 0.967 0.865 0.02 57 0.936 Q07837 R452W Disease 0.998 0.929 0.00 76 0.935 Q07837 R584T Disease 0.924 0.878 0.01 57 0.920 Q07837 T216M Disease 0.620 0.776 0.00 50 0.855 Q07837 T341A Disease NA 0.078 0.66 -3 0.114 Q07837 T652R Disease NA 0.305 NA 45 0.281 Q07837 Y151C Disease 0.996 0.855 0.00 60 0.933 Q07837 Y461H Disease 0.429 0.422 0.55 10 0.394 Q07837 Y582H Disease 0.947 0.705 0.00 46 0.882 Q07864 P99L Polymorphism 0.294 0.155 0.53 35 0.240 Q07864 F695I Polymorphism 0.514 0.868 0.00 24 0.657 Q07864 N336S Polymorphism 0.788 0.733 0.07 11 0.845 Q07864 R260Q Polymorphism 0.302 0.172 0.31 52 0.303 Q07864 A1712V Polymorphism 0.282 0.041 0.26 -1 0.154 Q07864 K1857R Polymorphism 0.142 0.069 0.38 -32 0.146 Q07864 N1396S Polymorphism 0.199 0.211 0.22 -32 0.206 Q07864 R2159C Polymorphism 0.654 0.213 0.04 66 0.762 Q07864 R2165H Polymorphism 0.607 0.603 0.04 15 0.585 Q07864 Y1395C Polymorphism 0.603 0.236 0.18 44 0.521 Q07869 R409T Polymorphism 0.233 0.500 0.43 44 0.641 Q07869 V227A Polymorphism NA 0.170 0.96 -17 0.124 Q07889 C441Y Disease NA 0.436 0.00 48 0.505 Q07889 D309Y Disease NA 0.233 0.04 24 0.382 Q07889 E108K Disease NA 0.146 0.12 26 0.252 Q07889 E433K Disease NA 0.562 0.01 10 0.502 Q07889 E846K Disease 0.197 0.613 0.73 -18 0.221 Q07889 G434R Disease NA 0.580 0.28 44 0.611 Q07889 I733F Disease 0.491 0.319 0.13 33 0.414 Q07889 L550P Disease NA 0.386 0.13 33 0.508 Q07889 M269R Disease NA 0.213 0.20 16 0.361 Q07889 Q977R Polymorphism 0.391 0.246 0.59 39 0.350 Q07889 R552G Disease NA 0.296 0.34 40 0.393 Q07889 R552K Disease NA 0.228 0.48 15 0.213 Q07889 R552S Disease NA 0.265 0.45 35 0.345 Q07889 S548R Disease NA 0.246 0.34 32 0.243 Q07889 T266K Disease NA 0.134 0.29 -12 0.188 Q07889 W432R Disease NA 0.589 0.17 38 0.723 Q07889 W729L Disease 0.248 0.165 0.80 16 0.134 Q07889 Y337C Disease NA 0.235 0.01 43 0.355 Q07889 Y702H Disease 0.760 0.236 0.31 49 0.599 Q07889 H1320R Polymorphism NA 0.118 0.07 -11 0.101 Q07890 S483N Polymorphism NA 0.091 0.49 -3 0.087 Q07912 P725L Polymorphism NA 0.037 1.00 -19 0.042 Q07912 T152M Polymorphism 0.274 0.518 0.08 -11 0.404 Q07912 R1038H Polymorphism NA 0.290 0.00 48 0.317 Q07954 V2059L Polymorphism NA 0.358 0.05 -10 0.270 Q07973 M374T Polymorphism 0.480 0.652 0.01 62 0.746 Q08043 E635A Polymorphism 0.706 0.800 0.17 29 0.798 Q08043 Q776R Polymorphism 0.249 0.105 0.93 -15 0.073 Q08043 R523Q Polymorphism 0.262 0.077 0.96 -13 0.049 Q08050 A402E Polymorphism 0.480 0.293 0.26 24 0.425 Q08050 F450L Polymorphism 0.808 0.070 1.00 -7 0.024 Q08050 P673L Polymorphism 0.926 0.203 0.00 28 0.520 Q08050 S643P Polymorphism 0.450 0.039 1.00 -37 0.010 Q08117 A168E Polymorphism 0.259 0.745 0.06 32 0.680 Q08170 G338A Polymorphism NA 0.132 0.51 -3 0.032 Q08170 Q438E Polymorphism NA 0.122 NA 13 0.104 Q08174 H25P Polymorphism NA 0.047 0.26 -39 0.014 Q08174 L15F Polymorphism NA 0.092 NA -47 0.053 Q08188 T13K Polymorphism NA 0.215 0.67 -19 0.170 Q08188 G654R Polymorphism 0.133 0.402 0.53 5 0.127 Q08188 I163L Polymorphism 0.229 0.897 0.04 6 0.528 Q08188 K562R Polymorphism 0.055 0.171 0.56 -27 0.075 Q08188 L687M Polymorphism 0.380 0.164 0.09 -11 0.283 Q08211 I894V Polymorphism 0.527 0.033 0.91 -14 0.039 Q08257 P66S Polymorphism 0.591 0.672 0.00 38 0.576 Q08289 S535L Disease 0.490 0.110 0.18 -22 0.107 Q08345 S17G Polymorphism 0.017 0.136 0.10 13 0.094 Q08345 A170D Polymorphism 0.446 0.233 0.00 49 0.400 Q08378 K1185R Polymorphism 0.210 0.081 0.34 -5 0.121 Q08397 G153D Polymorphism 0.082 0.166 0.03 44 0.233 Q08397 R141L Polymorphism 0.100 0.141 0.00 19 0.182 Q08426 V40G Polymorphism NA 0.396 0.28 -34 0.407 Q08426 L715S Polymorphism 0.135 0.136 0.52 1 0.097 Q08426 Q685K Polymorphism 0.454 0.467 1.00 -21 0.291 Q08426 T606P Polymorphism 0.404 0.313 1.00 -14 0.184 Q08431 R3S Polymorphism NA 0.078 0.44 -32 0.024 Q08477 A269D Polymorphism 0.381 0.436 0.61 -35 0.221 Q08477 V270I Polymorphism 0.335 0.045 0.12 -16 0.317 Q08477 Y106C Polymorphism 0.306 0.688 0.07 15 0.530 Q08493 R289Q Polymorphism NA 0.192 0.33 -32 0.222 Q08493 S131L Polymorphism NA 0.761 0.04 27 0.654 Q08554 C848F Polymorphism 0.130 0.526 0.02 0 0.373 Q08554 V460I Polymorphism 0.205 0.305 0.22 5 0.308 Q08708 T71I Polymorphism 0.619 0.923 0.00 42 0.692 Q08752 D196V Polymorphism 0.600 0.657 0.02 16 0.585 Q08752 G335E Polymorphism 0.126 0.199 1.00 -27 0.033 Q08828 A940T Polymorphism 0.249 0.263 0.58 25 0.356 Q08828 V984M Polymorphism 0.827 0.741 0.00 32 0.885 Q08830 I72V Polymorphism NA 0.114 0.23 -29 0.164 Q08830 M114V Polymorphism 0.219 0.824 0.06 51 0.781 Q08830 P105L Polymorphism 0.113 0.515 0.36 -15 0.085 Q08830 W256L Polymorphism 0.572 0.845 0.00 67 0.710 Q08830 Y140F Polymorphism 0.991 0.775 0.00 52 0.931 Q08881 R193Q Polymorphism 0.377 0.224 0.64 17 0.335 Q08881 R581W Polymorphism 0.743 0.730 0.01 18 0.792 Q08881 V587I Polymorphism 0.112 0.121 0.53 -19 0.122 Q08945 L225V Polymorphism 0.577 0.909 0.00 49 0.883 Q08999 Y210C Polymorphism 0.671 0.228 0.18 -9 0.444 Q08AD1 P958L Polymorphism 0.788 0.118 0.31 -12 0.325 Q08AD1 P1039R Polymorphism 0.281 0.246 0.34 21 0.255 Q08AF3 A797V Polymorphism 0.231 0.058 0.71 -15 0.057 Q08AG5 I642M Polymorphism NA 0.121 0.03 -8 0.016 Q08AG5 K226E Polymorphism 0.068 0.136 1.00 -6 0.073 Q08AG5 T276A Polymorphism 0.215 0.171 0.07 30 0.301 Q08AG5 V113M Polymorphism 0.089 0.147 0.24 -38 0.136 Q08AG5 V329A Polymorphism 0.121 0.163 0.01 -5 0.142 Q08AH1 I479V Polymorphism 0.261 0.136 0.25 12 0.248 Q08AH3 A561T Polymorphism 0.205 0.286 0.26 -49 0.263 Q08AH3 S513L Polymorphism 0.321 0.507 0.05 -16 0.392 Q08AH3 V335L Polymorphism 0.192 0.285 0.66 -3 0.248 Q08AH3 V337G Polymorphism 0.308 0.236 0.54 19 0.284 Q08AI8 A170T Polymorphism 0.057 0.032 0.44 -46 0.032 Q08AN1 H451R Polymorphism 0.484 0.244 0.46 -2 0.295 Q08ER8 P55A Polymorphism 0.636 0.691 0.04 20 0.677 Q08ER8 M573V Polymorphism NA 0.177 0.23 1 0.209 Q08ER8 V439D Polymorphism 0.550 0.301 0.62 22 0.622 Q09160 F133L Polymorphism 0.259 0.232 0.85 -25 0.297 Q09160 G131W Polymorphism 0.626 0.846 0.07 49 0.718 Q09160 R169H Polymorphism 0.507 0.879 0.13 -1 0.606 Q09160 R205H Polymorphism 0.767 0.852 0.03 33 0.808 Q09428 G7R Disease NA 0.500 0.00 62 0.789 Q09428 F27S Disease NA 0.811 0.00 46 0.797 Q09428 G70E Disease NA 0.563 0.33 54 0.754 Q09428 R74Q Disease NA 0.413 0.34 44 0.572 Q09428 R74W Disease NA 0.650 0.03 47 0.712 Q09428 V21D Disease NA 0.555 0.00 48 0.585 Q09428 V86A Disease NA 0.407 0.22 -2 0.400 Q09428 A116P Disease NA 0.652 0.22 31 0.719 Q09428 C418R Disease 0.220 0.896 0.02 45 0.678 Q09428 C435R Disease 0.552 0.845 0.09 26 0.837 Q09428 D310N Disease 0.555 0.475 0.14 34 0.575 Q09428 D673N Polymorphism 0.099 0.301 0.24 -3 0.233 Q09428 E501K Disease 0.353 0.955 0.01 61 0.861 Q09428 F132L Disease NA 0.468 1.00 -9 0.410 Q09428 F591L Disease 0.091 0.180 0.77 -57 0.131 Q09428 F686S Disease 0.753 0.782 0.00 58 0.809 Q09428 G111R Disease NA 0.227 0.18 -4 0.388 Q09428 G716V Disease 0.997 0.848 0.00 74 0.939 Q09428 H125Q Disease NA 0.442 0.44 34 0.299 Q09428 K719T Disease 0.997 0.793 0.00 70 0.924 Q09428 K889T Disease 0.445 0.109 0.30 14 0.266 Q09428 L104V Polymorphism NA 0.248 0.35 -34 0.222 Q09428 L213R Disease 0.529 0.656 0.07 24 0.601 Q09428 L503P Disease 0.845 0.927 0.00 60 0.913 Q09428 L508P Disease 0.775 0.878 0.03 51 0.858 Q09428 L582V Disease 0.443 0.423 0.32 10 0.350 Q09428 M233R Disease 0.630 0.755 0.13 40 0.845 Q09428 N188S Disease NA 0.249 0.53 -13 0.217 Q09428 N406D Disease 0.298 0.695 0.21 -22 0.477 Q09428 P551R Disease 0.493 0.911 0.22 54 0.836 Q09428 R495Q Disease 0.994 0.910 0.23 58 0.887 Q09428 R620C Disease 0.581 0.583 0.05 30 0.769 Q09428 R841G Disease 0.996 0.908 0.00 62 0.930 Q09428 S956F Disease 0.212 0.672 0.05 33 0.632 Q09428 V187D Disease NA 0.500 0.01 22 0.727 Q09428 A1457T Disease 0.578 0.194 0.02 1 0.459 Q09428 D1471H Disease 0.833 0.513 0.08 37 0.664 Q09428 D1471N Disease 0.642 0.513 0.61 18 0.461 Q09428 E1506K Disease 0.995 0.800 0.01 75 0.909 Q09428 G1342E Disease 0.813 0.922 0.00 69 0.896 Q09428 G1378R Disease 0.999 0.825 0.00 77 0.934 Q09428 G1381S Disease 0.717 0.783 0.00 70 0.884 Q09428 G1400R Disease 0.998 0.810 0.00 70 0.931 Q09428 G1478R Disease 0.735 0.937 0.00 74 0.902 Q09428 H1023Y Disease 0.527 0.506 1.00 -7 0.369 Q09428 I1424V Disease 0.274 0.252 0.70 36 0.301 Q09428 K1336N Disease 0.240 0.454 0.45 1 0.301 Q09428 K1384Q Disease 0.999 0.560 0.00 72 0.918 Q09428 L1147R Disease 0.825 0.454 0.08 37 0.688 Q09428 L1349Q Disease 0.762 0.390 0.18 39 0.643 Q09428 L1450P Disease 0.876 0.748 0.00 49 0.906 Q09428 L1543P Disease 0.850 0.518 0.06 20 0.670 Q09428 L1551V Disease 0.382 0.281 0.02 -52 0.347 Q09428 N1295K Disease 0.650 0.447 0.89 -8 0.574 Q09428 R1182Q Disease 0.666 0.228 0.59 0 0.495 Q09428 R1214Q Disease 0.666 0.825 0.19 53 0.846 Q09428 R1214W Disease 0.935 0.956 0.00 55 0.904 Q09428 R1352H Disease 0.801 0.457 0.14 50 0.696 Q09428 R1352P Disease 0.826 0.813 0.08 55 0.862 Q09428 R1379C Disease 0.914 0.660 0.01 65 0.907 Q09428 R1393H Disease 0.503 0.648 0.02 70 0.769 Q09428 R1418H Disease 0.998 0.706 0.06 73 0.896 Q09428 R1420C Disease 0.914 0.269 0.01 37 0.650 Q09428 R1436Q Disease 0.677 0.681 0.09 60 0.600 Q09428 R1486K Disease 0.473 0.825 1.00 17 0.406 Q09428 R1493Q Disease 0.999 0.792 0.00 67 0.929 Q09428 R1493W Disease 0.999 0.942 0.00 66 0.935 Q09428 S1386F Disease 0.833 0.686 0.00 49 0.896 Q09428 T1130P Disease 0.562 0.587 0.36 27 0.756 Q09428 T1138M Disease 0.831 0.121 0.12 -23 0.392 Q09428 V1360M Disease 0.694 0.446 0.01 20 0.664 Q09428 V1550D Disease 0.994 0.851 0.00 58 0.938 Q09428 V1572I Polymorphism 0.230 0.086 0.27 -5 0.169 Q09470 A242P Disease 0.635 0.819 0.14 46 0.860 Q09470 E325D Disease 0.652 0.729 0.00 11 0.688 Q09470 F184C Disease 0.945 0.758 0.00 48 0.890 Q09470 F249I Disease 0.807 0.837 0.00 69 0.926 Q09470 I177R Disease 0.721 0.783 0.00 68 0.904 Q09470 L329I Disease 0.593 0.640 0.00 14 0.553 Q09470 P244H Disease 0.923 0.845 0.00 50 0.911 Q09470 R239S Disease 0.791 0.876 0.00 50 0.901 Q09470 S342I Disease 0.878 0.794 0.00 30 0.861 Q09470 T226A Disease 0.339 0.514 1.00 -21 0.409 Q09470 T226K Disease 0.557 0.812 0.11 33 0.846 Q09470 T226M Disease 0.727 0.752 0.05 -14 0.784 Q09470 T226R Disease 0.602 0.869 0.08 23 0.857 Q09470 V174F Disease 0.790 0.608 0.01 -16 0.782 Q09470 V404I Disease 0.432 0.325 0.40 -24 0.290 Q09470 V408A Disease 0.688 0.572 0.00 16 0.768 Q09472 I997V Polymorphism 0.238 0.043 0.54 0 0.053 Q09472 M289V Polymorphism NA 0.075 0.11 0 0.085 Q09472 Q2223P Polymorphism NA 0.194 0.18 0 0.343 Q09472 T2174S Polymorphism NA 0.166 1.00 0 0.073 Q09666 G4561D Polymorphism NA 0.112 0.76 1 0.128 Q09666 I4613V Polymorphism NA 0.090 1.00 -36 0.107 Q09666 P2439L Polymorphism NA 0.184 0.00 30 0.337 Q09666 Q3003K Polymorphism NA 0.167 0.61 -20 0.106 Q09666 S3724P Polymorphism NA 0.121 0.27 -34 0.197 Q09666 T5415A Polymorphism NA 0.064 0.74 -13 0.096 Q09666 V3190I Polymorphism NA 0.075 0.16 11 0.187 Q09FC8 I229L Polymorphism 0.532 0.257 0.12 17 0.483 Q09FC8 I233V Polymorphism 0.487 0.215 0.11 -14 0.141 Q09FC8 N463D Polymorphism 0.467 0.268 0.28 1 0.331 Q09FC8 Y241C Polymorphism 0.534 0.193 1.00 60 0.259 Q09MP3 V876L Polymorphism NA 0.079 NA 49 0.064 Q09MP3 G1037D Polymorphism NA 0.079 NA 48 0.060 Q0D2J5 Y324H Polymorphism 0.075 0.324 0.31 -18 0.132 Q0D2J5 Y327H Polymorphism 0.202 0.321 0.00 40 0.376 Q0D2K0 A176D Disease 0.881 0.782 0.03 24 0.822 Q0D2K0 G142V Disease 0.527 0.908 0.10 37 0.864 Q0D2K0 G230R Disease 0.989 0.906 0.00 68 0.954 Q0D2K0 G297R Disease 0.964 0.902 0.01 65 0.948 Q0D2K0 H237N Disease 0.702 0.781 0.23 21 0.800 Q0D2K0 S208F Disease 0.975 0.696 0.01 29 0.867 Q0D2K5 P157L Polymorphism NA 0.500 0.44 29 0.471 Q0JRZ9 M371V Polymorphism NA 0.107 0.98 31 0.206 Q0P5N6 S10R Polymorphism NA 0.142 0.01 47 0.167 Q0P641 S152G Polymorphism NA 0.124 NA 51 0.131 Q0P670 Q376R Polymorphism NA 0.023 NA 5 0.022 Q0P670 S108A Polymorphism NA 0.114 0.35 46 0.141 Q0P6D6 C813R Polymorphism NA 0.040 NA 21 0.021 Q0P6D6 G529D Polymorphism NA 0.090 NA 20 0.067 Q0VAF6 L111M Polymorphism NA 0.208 NA 14 0.139 Q0VAK6 A560V Polymorphism NA 0.087 NA -28 0.026 Q0VAK6 I263T Polymorphism 0.345 0.766 0.01 33 0.721 Q0VAK6 K438M Polymorphism 0.584 0.038 NA -21 0.069 Q0VD83 A419P Polymorphism NA 0.139 0.17 23 0.037 Q0VDD7 G267R Polymorphism 0.460 0.052 0.23 10 0.044 Q0VDD7 Q500R Polymorphism 0.219 0.069 0.51 37 0.050 Q0VDD8 P274L Polymorphism NA 0.336 NA -6 0.123 Q0VDD8 T220S Polymorphism NA 0.080 NA 0 0.043 Q0VDD8 K2671E Polymorphism 0.735 0.146 0.65 -3 0.103 Q0VDG4 D18N Polymorphism NA 0.327 0.48 15 0.304 Q0VF96 L1101V Polymorphism NA 0.634 0.04 15 0.593 Q0VF96 M1270V Polymorphism NA 0.147 0.15 -5 0.067 Q0ZGT2 G245R Polymorphism NA 0.688 0.00 44 0.770 Q0ZGT2 R335K Polymorphism NA 0.074 0.00 -29 0.098 Q0ZLH3 T54I Disease NA 0.550 0.56 44 0.727 Q0ZLH3 R183W Disease NA 0.251 0.11 34 0.342 Q0ZLH3 R265C Polymorphism NA 0.275 NA 40 0.116 Q10469 H262R Disease 0.669 0.938 NA 52 0.923 Q10469 N318D Disease 0.486 0.832 NA 69 0.806 Q10469 S290F Disease 0.841 0.681 NA 40 0.786 Q10471 V554M Polymorphism NA 0.139 0.09 14 0.243 Q10472 Y414D Polymorphism 0.991 0.815 0.00 69 0.945 Q10571 Q382H Polymorphism NA 0.070 0.22 9 0.044 Q10588 A77V Polymorphism 0.171 0.300 0.20 -21 0.201 Q10588 I101V Polymorphism 0.108 0.106 0.66 -11 0.088 Q10588 R125H Polymorphism 0.493 0.189 0.06 -3 0.215 Q10589 V143F Polymorphism NA 0.158 0.19 14 0.082 Q10981 I25V Polymorphism 0.164 0.267 0.24 -26 0.176 Q10981 D172N Polymorphism 0.268 0.435 0.14 0 0.286 Q10981 G258S Polymorphism 0.198 0.822 0.05 -16 0.524 Q11128 P187L Polymorphism 0.206 0.629 0.02 12 0.522 Q12765 Q338R Polymorphism 0.481 0.280 0.03 27 0.411 Q12765 S189N Polymorphism 0.103 0.032 1.00 -50 0.022 Q12768 L619F Disease 0.505 0.539 0.00 37 0.716 Q12768 N471D Disease 0.351 0.129 0.14 0 0.220 Q12768 V626F Disease 0.700 0.893 0.00 47 0.876 Q12769 T351A Polymorphism 0.189 0.193 0.38 32 0.251 Q12772 G595A Polymorphism NA 0.103 1.00 -41 0.052 Q12772 M536L Polymorphism 0.061 0.095 1.00 -14 0.047 Q12772 V623M Polymorphism 0.347 0.099 0.00 1 0.214 Q12788 E294Q Polymorphism 0.243 0.238 0.36 -36 0.261 Q12788 S457P Polymorphism NA 0.657 0.30 16 0.533 Q12789 E2077K Polymorphism NA 0.273 NA 23 0.251 Q12789 Q1889E Polymorphism 0.311 0.072 NA -4 0.066 Q12791 D434G Disease 0.363 0.472 0.01 39 0.396 Q12794 E268K Disease 0.974 0.891 0.00 71 0.961 Q12802 G624V Polymorphism NA 0.154 NA 27 0.137 Q12802 W494R Polymorphism NA 0.133 NA 26 0.113 Q12802 G2457S Polymorphism 0.594 0.167 0.02 6 0.254 Q12802 M1216T Polymorphism NA 0.104 NA 16 0.021 Q12802 P1062A Polymorphism NA 0.095 NA 25 0.079 Q12805 R345W Disease 0.706 0.286 0.01 49 0.623 Q12809 A78P Disease NA 0.727 0.12 11 0.738 Q12809 C66G Disease NA 0.990 0.00 47 0.878 Q12809 F29L Disease NA 0.961 0.00 23 0.774 Q12809 G47V Disease NA 0.924 0.00 46 0.879 Q12809 G53R Disease NA 0.965 0.00 66 0.913 Q12809 H70R Disease NA 0.445 0.06 42 0.572 Q12809 L86R Disease NA 0.905 0.00 30 0.828 Q12809 N33T Disease NA 0.947 0.00 49 0.900 Q12809 P72Q Disease NA 0.378 0.04 4 0.344 Q12809 R56Q Disease NA 0.960 0.00 45 0.875 Q12809 T65P Disease NA 0.746 0.01 32 0.791 Q12809 A490T Polymorphism 0.560 0.801 0.51 38 0.744 Q12809 A558P Disease 0.672 0.906 0.03 46 0.853 Q12809 A561T Disease 0.936 0.748 0.07 37 0.876 Q12809 A561V Disease 0.961 0.729 0.08 36 0.882 Q12809 A614V Disease 0.548 0.607 0.01 49 0.760 Q12809 D609N Disease 0.384 0.479 0.34 42 0.432 Q12809 E637K Disease 0.971 0.903 0.01 62 0.927 Q12809 F627L Disease 0.941 0.662 0.01 50 0.908 Q12809 F640L Disease 0.941 0.647 0.12 27 0.862 Q12809 F805C Disease 0.788 0.947 0.00 64 0.775 Q12809 F805S Disease 0.553 0.922 0.00 44 0.878 Q12809 G572C Disease 0.894 0.831 0.01 53 0.916 Q12809 G572R Disease 0.848 0.895 0.00 68 0.915 Q12809 G584S Disease 0.638 0.302 0.48 34 0.637 Q12809 G601S Disease NA 0.286 0.35 -20 0.278 Q12809 G604S Disease NA 0.230 0.03 47 0.421 Q12809 G626S Disease 0.975 0.811 0.00 39 0.895 Q12809 G628S Disease 0.975 0.809 0.01 61 0.926 Q12809 I593R Disease 0.708 0.538 0.01 70 0.895 Q12809 I593T Disease 0.380 0.430 0.09 24 0.397 Q12809 K525N Polymorphism 0.972 0.804 0.00 21 0.902 Q12809 K638E Disease 0.964 0.714 0.09 21 0.858 Q12809 K897T Polymorphism 0.275 0.196 0.26 -6 0.224 Q12809 L552S Disease 0.983 0.641 0.03 16 0.809 Q12809 L564P Disease 0.863 0.833 0.03 54 0.918 Q12809 L615V Disease 0.922 0.511 0.00 52 0.874 Q12809 M645L Disease 0.603 0.773 0.05 6 0.523 Q12809 N470D Disease 0.957 0.762 0.01 58 0.923 Q12809 N588D Disease 0.294 0.395 0.50 14 0.352 Q12809 N588K Disease 0.248 0.454 0.76 15 0.324 Q12809 N629D Disease 0.956 0.255 0.14 54 0.792 Q12809 N629K Disease 0.975 0.526 0.08 54 0.912 Q12809 N629S Disease 0.963 0.460 0.07 46 0.826 Q12809 N633S Disease 0.365 0.293 0.38 34 0.390 Q12809 N861I Disease 0.986 0.933 0.00 41 0.928 Q12809 P347S Disease NA 0.162 0.24 33 0.262 Q12809 P451L Disease 0.830 0.612 0.20 23 0.828 Q12809 P632S Disease 0.378 0.617 0.01 35 0.562 Q12809 P917L Disease 0.183 0.153 0.64 -14 0.195 Q12809 R100G Disease NA 0.864 0.01 50 0.887 Q12809 R176W Disease NA 0.277 0.00 62 0.483 Q12809 R312C Disease NA 0.303 0.00 49 0.526 Q12809 R531Q Disease 0.971 0.865 0.02 34 0.893 Q12809 R534C Disease 0.992 0.898 0.00 44 0.934 Q12809 R582C Disease 0.639 0.669 0.09 52 0.814 Q12809 R752Q Disease 0.658 0.523 0.05 51 0.675 Q12809 R752W Disease 0.933 0.834 0.02 51 0.917 Q12809 R823W Disease 0.883 0.880 0.00 39 0.892 Q12809 R922W Disease 0.388 0.160 0.02 61 0.352 Q12809 S818L Disease 0.720 0.756 0.02 36 0.826 Q12809 T436M Disease NA 0.120 0.10 -2 0.240 Q12809 T474I Disease 0.980 0.579 0.03 50 0.962 Q12809 T613M Disease 0.817 0.515 0.18 57 0.844 Q12809 V612L Disease 0.310 0.354 0.10 37 0.390 Q12809 V630A Disease 0.848 0.383 0.16 32 0.704 Q12809 V630L Disease 0.764 0.369 0.16 35 0.662 Q12809 V822M Disease 0.413 0.585 0.00 62 0.780 Q12809 W585C Disease 0.973 0.959 0.00 77 0.953 Q12809 Y569H Disease 0.718 0.702 0.00 59 0.676 Q12809 Y611H Disease 0.965 0.756 0.00 78 0.922 Q12809 P1016L Polymorphism 0.249 0.075 0.09 -13 0.095 Q12809 P1020S Polymorphism 0.081 0.100 0.14 -17 0.082 Q12809 P1026L Polymorphism 0.069 0.142 0.17 -5 0.121 Q12809 R1055Q Polymorphism 0.150 0.197 0.93 3 0.173 Q12816 S738G Polymorphism 0.161 0.272 0.01 -13 0.223 Q12834 R479Q Polymorphism 0.180 0.230 0.62 -11 0.225 Q12836 P295S Polymorphism 0.507 0.197 0.71 42 0.335 Q12837 I40T Polymorphism NA 0.145 0.24 10 0.045 Q12840 Y63C Disease 0.910 0.857 0.00 54 0.918 Q12840 A361V Disease 0.303 0.331 0.34 4 0.337 Q12840 E251K Disease 0.718 0.973 0.00 78 0.932 Q12840 K253N Disease 0.833 0.592 0.05 20 0.724 Q12840 K257N Disease 0.696 0.745 0.01 27 0.829 Q12840 M198T Disease 0.826 0.907 0.00 56 0.922 Q12840 N256S Disease 0.999 0.955 0.00 55 0.933 Q12840 R204Q Disease 0.999 0.751 0.00 74 0.945 Q12840 R280C Disease 0.999 0.911 0.00 64 0.950 Q12840 R280H Disease 0.999 0.888 0.00 65 0.949 Q12840 R280L Disease 0.999 0.926 0.00 58 0.950 Q12840 Y276C Disease 0.832 0.788 0.01 46 0.882 Q12860 E824G Polymorphism 0.733 0.165 0.08 34 0.503 Q12860 V798L Polymorphism 0.112 0.403 0.15 2 0.213 Q12864 E739A Polymorphism NA 0.323 0.90 9 0.308 Q12864 I446T Polymorphism 0.628 0.177 0.29 -12 0.410 Q12866 A282T Polymorphism 0.120 0.130 0.52 43 0.122 Q12866 E540K Disease NA 0.111 0.46 30 0.197 Q12866 I518V Polymorphism 0.102 0.209 0.92 -31 0.168 Q12866 I871T Disease NA 0.288 0.61 -20 0.176 Q12866 N329S Polymorphism NA 0.109 0.50 43 0.198 Q12866 Q662E Polymorphism NA 0.642 0.32 9 0.448 Q12866 R293H Polymorphism 0.188 0.129 0.17 18 0.076 Q12866 R466K Polymorphism NA 0.137 0.99 -11 0.086 Q12866 R865W Polymorphism NA 0.662 0.11 22 0.746 Q12866 S118N Polymorphism 0.209 0.091 0.33 34 0.067 Q12866 S661C Disease NA 0.500 0.04 20 0.715 Q12866 V185M Polymorphism 0.264 0.170 0.03 46 0.279 Q12872 E538G Polymorphism 0.277 0.114 0.01 17 0.170 Q12873 A3V Polymorphism NA 0.170 NA 5 0.021 Q12882 M166V Polymorphism 0.286 0.289 0.05 39 0.391 Q12882 R235W Polymorphism 0.787 0.904 0.00 57 0.939 Q12882 S534N Polymorphism NA 0.747 0.03 38 0.651 Q12882 V995F Polymorphism 0.572 0.872 0.00 59 0.902 Q12887 T28I Polymorphism NA 0.085 0.06 21 0.081 Q12887 T62S Polymorphism NA 0.154 0.82 -8 0.102 Q12887 D336G Disease 0.824 0.888 0.02 46 0.893 Q12887 D336V Disease 0.932 0.896 0.01 46 0.904 Q12887 N204K Disease 0.722 0.833 0.02 52 0.898 Q12887 P225L Disease 0.872 0.869 0.00 45 0.827 Q12887 T196K Disease NA 0.772 0.01 49 0.844 Q12888 D841G Polymorphism 0.292 0.389 0.04 -19 0.200 Q12888 G412S Polymorphism 0.082 0.038 0.12 -12 0.043 Q12888 Q699R Polymorphism 0.115 0.182 0.28 27 0.145 Q12888 A1170G Polymorphism 0.319 0.434 NA 27 0.253 Q12888 E1137K Polymorphism 0.109 0.059 0.23 20 0.040 Q12888 I1174V Polymorphism 0.065 0.040 NA -36 0.049 Q12889 D332E Polymorphism 0.105 0.718 0.22 18 0.299 Q12889 E676Q Polymorphism NA 0.160 NA -7 0.018 Q12889 H604Q Polymorphism NA 0.138 0.02 28 0.133 Q12889 M479V Polymorphism NA 0.256 0.31 39 0.195 Q12889 S536G Polymorphism NA 0.136 0.70 29 0.053 Q12889 Y514H Polymorphism NA 0.171 0.55 13 0.023 Q12901 K379R Polymorphism 0.453 0.418 0.10 40 0.493 Q12904 P79A Polymorphism NA 0.119 0.11 12 0.138 Q12904 T104A Polymorphism NA 0.097 0.77 -42 0.079 Q12904 T117A Polymorphism NA 0.119 0.82 -53 0.087 Q12906 D50H Polymorphism 0.727 0.203 0.00 36 0.483 Q12908 L243P Disease 0.950 0.762 0.21 17 0.813 Q12908 T262M Disease 0.985 0.562 0.00 58 0.921 Q12912 T94A Polymorphism NA 0.054 0.00 -16 0.111 Q12913 A293T Polymorphism NA 0.076 0.45 31 0.089 Q12913 E872D Polymorphism NA 0.157 0.22 30 0.166 Q12913 R326Q Polymorphism NA 0.052 0.52 14 0.072 Q12913 V372I Polymorphism NA 0.178 0.23 -33 0.151 Q12913 I1235T Polymorphism 0.097 0.596 0.20 41 0.183 Q12923 E1625K Polymorphism NA 0.123 0.15 41 0.139 Q12923 I1522M Polymorphism NA 0.125 0.03 37 0.271 Q12923 L1419P Polymorphism NA 0.710 0.00 32 0.752 Q12923 Y2081D Polymorphism NA 0.212 0.03 3 0.132 Q12929 D761E Polymorphism 0.331 0.105 1.00 -26 0.100 Q12931 D395E Polymorphism 0.564 0.881 0.01 37 0.608 Q12931 R307G Polymorphism 0.266 0.222 0.15 7 0.214 Q12934 D656E Polymorphism 0.088 0.064 0.14 2 0.048 Q12948 F112S Disease 0.995 0.792 0.00 55 0.921 Q12948 L130F Disease 0.997 0.783 0.00 66 0.922 Q12950 I134F Polymorphism 0.948 0.679 0.05 49 0.884 Q12951 P243S Polymorphism 0.522 0.323 0.48 -16 0.468 Q12955 I3117V Polymorphism NA 0.104 1.00 -23 0.062 Q12955 I4257V Polymorphism NA 0.057 0.77 -21 0.010 Q12955 K3123R Polymorphism NA 0.049 0.10 -4 0.040 Q12959 P899L Polymorphism 0.323 0.917 0.00 38 0.733 Q12959 R278Q Polymorphism 0.150 0.211 0.46 1 0.163 Q12968 E94A Polymorphism 0.286 0.111 1.00 0 0.097 Q12968 L100S Polymorphism 0.086 0.147 0.54 -26 0.097 Q12968 P136L Polymorphism 0.335 0.206 0.11 20 0.327 Q12968 P382S Polymorphism 0.232 0.088 0.65 -21 0.127 Q12981 Q14H Polymorphism 0.513 0.588 NA 29 0.714 Q12986 P760S Polymorphism 0.467 0.720 0.13 36 0.643 Q13002 M867I Polymorphism NA 0.123 0.40 -49 0.167 Q13003 S310A Polymorphism 0.057 0.086 1.00 6 0.076 Q13007 H125R Polymorphism 0.508 0.292 0.08 13 0.485 Q13007 Y124H Polymorphism 0.582 0.588 0.49 31 0.472 Q13009 G247R Polymorphism 0.186 0.419 0.00 16 0.210 Q13009 G247V Polymorphism 0.215 0.380 0.00 -12 0.224 Q13011 E41A Polymorphism NA 0.077 0.08 13 0.088 Q13011 G217R Polymorphism 0.992 0.918 0.00 71 0.952 Q13018 M292V Polymorphism 0.121 0.332 0.14 49 0.204 Q13018 R142Q Polymorphism 0.438 0.212 0.71 37 0.283 Q13018 G1106S Polymorphism 0.054 0.299 0.75 -6 0.151 Q13023 A337V Polymorphism NA 0.022 NA 17 0.015 Q13023 E892K Polymorphism 0.334 0.242 0.23 28 0.362 Q13023 N408S Polymorphism NA 0.029 NA -20 0.023 Q13023 N558D Polymorphism NA 0.070 0.05 40 0.081 Q13023 D2209H Polymorphism NA 0.109 0.01 54 0.162 Q13023 E2267D Polymorphism NA 0.054 0.05 32 0.073 Q13023 N2035D Polymorphism 0.221 0.062 0.00 73 0.098 Q13023 T1516A Polymorphism 0.145 0.048 NA 35 0.070 Q13023 V1522I Polymorphism 0.194 0.040 NA 7 0.056 Q13029 S450N Polymorphism NA 0.032 0.03 -23 0.024 Q13043 P416L Polymorphism 0.073 0.203 0.43 7 0.215 Q13043 R310Q Polymorphism 0.347 0.210 0.30 -12 0.287 Q13043 V312M Polymorphism 0.180 0.137 0.18 -22 0.206 Q13049 D487N Disease 0.288 0.754 0.00 46 0.749 Q13049 P130S Disease 0.354 0.068 0.46 22 0.070 Q13049 R394H Disease 0.476 0.930 0.13 25 0.743 Q13049 T257R Polymorphism 0.360 0.130 0.57 62 0.296 Q13061 S339N Polymorphism 0.246 0.149 0.35 32 0.080 Q13061 T128S Polymorphism 0.170 0.128 0.00 3 0.138 Q13075 V535M Polymorphism 0.109 0.120 0.06 25 0.147 Q13077 M139T Polymorphism 0.247 0.097 0.55 -8 0.118 Q13084 H27Y Polymorphism 0.680 0.500 0.18 12 0.718 Q13085 A2271V Polymorphism 0.175 0.144 1.00 -28 0.104 Q13087 P39S Polymorphism NA 0.228 0.05 -21 0.254 Q13087 E185K Polymorphism 0.666 0.761 0.06 9 0.770 Q13087 T119R Polymorphism 0.973 0.862 0.00 72 0.934 Q13087 T286M Polymorphism 0.927 0.475 0.01 16 0.690 Q13093 I198T Polymorphism 0.252 0.118 0.74 -34 0.133 Q13093 K191N Polymorphism 0.454 0.222 0.08 -22 0.288 Q13093 Q281R Disease 0.507 0.310 0.57 -6 0.459 Q13093 V279F Disease 0.543 0.476 0.06 35 0.701 Q13099 M383I Polymorphism 0.116 0.063 0.49 -4 0.082 Q13103 S38F Polymorphism 0.689 0.159 0.03 19 0.353 Q13106 G122V Polymorphism 0.053 0.500 0.12 17 0.295 Q13106 P384L Polymorphism 0.939 0.355 0.03 40 0.705 Q13107 Y620C Polymorphism NA 0.918 0.14 31 0.780 Q13111 A923V Polymorphism NA 0.102 NA 12 0.065 Q13111 D167V Polymorphism 0.582 0.305 0.00 25 0.498 Q13111 K850R Polymorphism 0.168 0.070 NA -34 0.062 Q13114 M129T Polymorphism 0.421 0.079 0.56 18 0.096 Q13127 E692D Polymorphism NA 0.107 0.01 6 0.038 Q13127 P797L Polymorphism NA 0.064 0.01 24 0.056 Q13129 G957D Polymorphism NA 0.382 0.16 59 0.363 Q13129 V932A Polymorphism NA 0.095 0.12 35 0.090 Q13131 M10L Polymorphism NA 0.175 0.28 24 0.263 Q13133 G52V Polymorphism NA 0.192 0.64 5 0.323 Q13136 V71I Polymorphism 0.120 0.157 0.17 -27 0.164 Q13137 P389A Polymorphism NA 0.060 0.00 19 0.165 Q13137 T273A Polymorphism NA 0.102 0.72 -1 0.123 Q13137 V248A Polymorphism NA 0.094 0.75 8 0.157 Q13144 T91A Disease 0.190 0.227 0.27 18 0.272 Q13144 V73G Disease 0.894 0.838 0.11 6 0.881 Q13144 E650K Disease NA 0.585 0.51 54 0.681 Q13144 G386V Disease 0.880 0.986 0.01 2 0.897 Q13144 I587V Polymorphism 0.111 0.070 1.00 -31 0.045 Q13144 L106F Disease 0.694 0.266 0.06 8 0.485 Q13144 N200T Polymorphism NA 0.303 0.59 3 0.153 Q13144 R113H Disease 0.220 0.193 0.29 -11 0.226 Q13144 R195C Disease 0.856 0.764 0.00 48 0.878 Q13144 R195H Disease 0.656 0.636 0.02 34 0.745 Q13144 R299H Disease 0.772 0.761 0.10 5 0.795 Q13144 R315G Disease 0.287 0.448 0.46 39 0.290 Q13144 R315H Disease 0.300 0.225 0.21 -3 0.218 Q13144 R339P Disease 0.531 0.911 0.03 34 0.658 Q13144 R339Q Disease 0.405 0.399 0.09 30 0.452 Q13144 R339W Disease 0.894 0.636 0.01 33 0.801 Q13144 V430A Disease 0.718 0.400 0.02 49 0.547 Q13144 W628R Disease NA 0.812 0.00 52 0.804 Q13148 A90V Polymorphism NA 0.105 0.07 13 0.194 Q13148 A315T Disease NA 0.164 0.20 -17 0.229 Q13148 A382T Disease 0.166 0.158 0.06 38 0.157 Q13148 D169G Disease 0.553 0.846 0.01 22 0.611 Q13148 G287S Disease 0.052 0.281 0.46 26 0.141 Q13148 G290A Disease 0.084 0.259 1.00 24 0.161 Q13148 G294A Disease 0.084 0.217 0.36 28 0.137 Q13148 G294V Disease 0.161 0.253 0.24 39 0.306 Q13148 G295R Disease 0.181 0.303 0.29 42 0.177 Q13148 G295S Disease 0.097 0.257 0.08 -22 0.154 Q13148 G298S Disease 0.097 0.284 0.57 -8 0.208 Q13148 G335D Disease 0.143 0.381 0.03 63 0.526 Q13148 G348C Disease NA 0.232 0.01 34 0.352 Q13148 M337V Disease 0.040 0.157 1.00 46 0.100 Q13148 N267S Disease 0.169 0.083 1.00 -21 0.078 Q13148 N390D Disease 0.112 0.296 0.02 45 0.311 Q13148 N390S Disease 0.066 0.186 0.15 37 0.212 Q13148 Q331K Disease 0.050 0.275 0.06 25 0.240 Q13148 R361S Disease 0.097 0.179 0.12 22 0.106 Q13148 S332N Disease 0.107 0.196 0.03 -1 0.174 Q13148 S379C Disease 0.480 0.224 0.00 44 0.254 Q13148 S379P Disease 0.282 0.160 0.01 0 0.232 Q13148 S393L Disease 0.240 0.174 0.01 27 0.156 Q13155 A129G Polymorphism 0.244 0.116 0.60 12 0.101 Q13155 L166I Polymorphism 0.285 0.111 0.59 -36 0.090 Q13156 A33T Polymorphism 0.220 0.059 0.55 21 0.081 Q13163 A427V Polymorphism 0.234 0.391 0.38 -33 0.206 Q13163 H118R Polymorphism NA 0.244 0.57 0 0.357 Q13164 G550A Polymorphism NA 0.159 0.13 25 0.190 Q13164 R535H Polymorphism NA 0.123 0.00 49 0.169 Q13183 L44F Polymorphism 0.380 0.466 0.05 -15 0.329 Q13183 M45L Polymorphism 0.480 0.810 0.09 33 0.641 Q13183 A310P Polymorphism 0.706 0.708 0.29 36 0.774 Q13183 F254L Polymorphism 0.821 0.676 0.02 3 0.810 Q13183 I550V Polymorphism 0.203 0.125 1.00 -63 0.108 Q13183 V477M Polymorphism 0.788 0.476 0.07 16 0.685 Q13188 F418C Polymorphism 0.061 0.204 0.18 23 0.214 Q13190 P51L Polymorphism NA 0.120 0.00 4 0.096 Q13190 Q72H Polymorphism 0.380 0.251 0.06 34 0.386 Q13191 N883D Polymorphism 0.257 0.074 0.71 27 0.052 Q13200 A176T Polymorphism NA 0.128 0.39 -17 0.215 Q13200 E313D Polymorphism 0.146 0.113 0.65 -38 0.109 Q13201 G883D Polymorphism 0.358 0.155 0.09 8 0.037 Q13201 T805A Polymorphism 0.363 0.030 0.73 -37 0.010 Q13201 T964R Polymorphism 0.223 0.282 0.01 49 0.201 Q13203 A114G Polymorphism 0.286 0.313 0.14 0 0.205 Q13216 A160V Disease 0.688 0.243 0.10 35 0.513 Q13216 A205P Disease 0.610 0.185 0.07 49 0.488 Q13219 S5I Polymorphism NA 0.261 NA 1 0.135 Q13219 P325L Polymorphism NA 0.649 0.00 18 0.704 Q13219 S1224Y Polymorphism 0.515 0.475 0.13 50 0.630 Q13231 Q171H Polymorphism 0.365 0.377 0.19 -3 0.408 Q13233 C443S Polymorphism NA 0.767 0.00 24 0.751 Q13237 T22S Polymorphism NA 0.056 0.46 -42 0.016 Q13253 A36P Disease 0.502 0.241 0.07 -10 0.364 Q13253 E48K Disease 0.600 0.411 0.00 37 0.341 Q13253 P35A Disease 0.689 0.283 0.00 47 0.422 Q13253 P35R Disease 0.832 0.500 0.00 39 0.692 Q13253 P35S Disease 0.725 0.344 0.00 46 0.432 Q13253 C184Y Disease 0.893 0.871 0.00 68 0.948 Q13253 G189C Disease 0.902 0.454 0.01 53 0.659 Q13253 I220N Disease 0.673 0.412 0.01 51 0.575 Q13253 P187S Disease 0.747 0.500 0.00 49 0.814 Q13253 P223L Disease 0.838 0.524 0.00 43 0.727 Q13253 R167G Disease 0.753 0.632 0.04 31 0.718 Q13253 R204L Disease 0.751 0.601 0.00 46 0.636 Q13253 W205C Disease 0.928 0.579 0.00 67 0.937 Q13253 W217G Disease 0.822 0.740 0.00 64 0.936 Q13253 Y222C Disease 0.907 0.573 0.00 60 0.752 Q13253 Y222D Disease 0.846 0.527 0.00 55 0.895 Q13255 E741D Polymorphism 0.430 0.197 0.41 2 0.258 Q13255 R285K Polymorphism NA 0.468 0.16 20 0.403 Q13255 V929I Polymorphism NA 0.384 0.05 -13 0.255 Q13258 R7C Polymorphism 0.802 0.326 0.01 54 0.500 Q13258 E301A Polymorphism 0.150 0.259 0.69 51 0.348 Q13258 G198E Polymorphism 0.594 0.341 0.06 53 0.600 Q13258 R332Q Polymorphism 0.681 0.266 0.55 11 0.455 Q13261 N182T Polymorphism NA 0.113 NA -27 0.073 Q13263 T794M Polymorphism 0.086 0.123 0.02 -7 0.179 Q13277 E83D Polymorphism 0.099 0.283 0.48 -12 0.220 Q13277 S285P Polymorphism NA 0.727 0.14 39 0.697 Q13285 R255L Disease 0.291 0.270 0.38 23 0.328 Q13286 E295K Disease 0.840 0.944 0.00 56 0.943 Q13286 L101P Disease 0.892 0.989 0.04 44 0.904 Q13286 L170P Disease 0.942 0.991 0.00 65 0.945 Q13286 R334C Disease 0.964 0.974 0.00 76 0.967 Q13286 R334H Disease 0.917 0.925 0.01 78 0.949 Q13286 V330F Disease 0.860 0.967 0.00 55 0.943 Q13287 S16L Polymorphism 0.361 0.102 0.33 1 0.060 Q13291 P333T Polymorphism 0.713 0.487 0.00 40 0.754 Q13303 E88K Polymorphism 0.553 0.888 0.63 59 0.899 Q13308 A777V Polymorphism NA 0.106 0.34 37 0.218 Q13308 H783R Polymorphism NA 0.154 0.36 54 0.273 Q13309 L87I Polymorphism NA 0.132 0.44 7 0.114 Q13309 P85L Polymorphism NA 0.660 0.03 4 0.535 Q13310 Y382F Polymorphism NA 0.570 0.66 9 0.404 Q13315 R45W Polymorphism 0.922 0.432 0.00 29 0.569 Q13315 S49C Polymorphism 0.822 0.236 0.00 21 0.506 Q13315 D126E Polymorphism 0.281 0.094 0.00 -49 0.075 Q13315 D140H Polymorphism 0.735 0.281 0.00 40 0.550 Q13315 D814E Polymorphism 0.324 0.153 0.00 -22 0.117 Q13315 F570S Disease 0.220 0.087 0.00 4 0.069 Q13315 F582L Polymorphism 0.232 0.084 0.00 12 0.106 Q13315 F858L Polymorphism 0.540 0.166 0.31 0 0.216 Q13315 G514D Polymorphism 0.683 0.383 0.00 52 0.552 Q13315 I323V Disease 0.450 0.178 0.00 0 0.150 Q13315 K224E Disease 0.552 0.246 0.00 16 0.506 Q13315 L546V Polymorphism 0.443 0.110 0.00 14 0.191 Q13315 L942F Polymorphism 0.640 0.218 0.00 19 0.342 Q13315 L950R Disease 0.555 0.243 0.00 14 0.533 Q13315 N504S Polymorphism 0.208 0.111 0.00 4 0.103 Q13315 N768D Disease 0.328 0.190 0.00 8 0.336 Q13315 P292L Disease 0.493 0.229 0.00 25 0.392 Q13315 P872S Polymorphism 0.217 0.096 0.20 -52 0.041 Q13315 R250Q Polymorphism 0.643 0.206 0.00 7 0.258 Q13315 R785C Disease 0.151 0.202 0.07 42 0.243 Q13315 R924W Polymorphism 0.910 0.624 0.00 7 0.750 Q13315 S333F Polymorphism 0.842 0.209 0.00 35 0.450 Q13315 S707P Polymorphism 0.246 0.116 0.00 -22 0.092 Q13315 S788R Polymorphism 0.475 0.097 0.02 30 0.145 Q13315 T761S Polymorphism 0.248 0.069 0.99 2 0.106 Q13315 T935A Polymorphism 0.208 0.111 0.11 -31 0.109 Q13315 T935M Polymorphism 0.368 0.156 0.03 -15 0.077 Q13315 V182L Polymorphism 0.163 0.154 0.02 -49 0.152 Q13315 V410A Polymorphism 0.424 0.127 0.00 27 0.171 Q13315 A1427T Polymorphism 0.613 0.088 0.01 29 0.119 Q13315 A2067D Disease 0.866 0.423 0.05 49 0.649 Q13315 A2726V Disease 0.494 0.472 0.04 30 0.510 Q13315 C2464R Polymorphism 0.698 0.361 0.42 50 0.519 Q13315 C2824Y Disease 0.896 0.692 0.09 57 0.875 Q13315 D1853N Polymorphism 0.706 0.158 0.18 46 0.274 Q13315 D1853V Polymorphism 0.893 0.238 0.07 51 0.588 Q13315 D2016G Disease 0.788 0.562 0.00 57 0.906 Q13315 D2625Q Disease 0.225 0.361 0.04 41 0.404 Q13315 D2870N Polymorphism 0.716 0.878 0.03 60 0.919 Q13315 E1091D Disease 0.436 0.120 0.56 -5 0.092 Q13315 E1313Q Polymorphism 0.705 0.112 0.02 31 0.144 Q13315 E2570G Polymorphism 0.523 0.119 0.17 43 0.207 Q13315 E2668G Disease 0.671 0.466 0.04 50 0.672 Q13315 E2904G Disease 0.809 0.890 0.00 38 0.885 Q13315 F2827C Disease 0.910 0.736 0.03 59 0.912 Q13315 G2063E Disease 0.856 0.733 0.05 68 0.816 Q13315 G2287A Polymorphism 0.904 0.274 0.13 41 0.548 Q13315 G2709S Polymorphism 0.943 0.910 0.00 54 0.922 Q13315 G2867R Disease 0.912 0.950 0.00 66 0.944 Q13315 H1082L Disease 0.695 0.176 0.00 44 0.250 Q13315 H1380Y Polymorphism 0.268 0.110 1.00 -7 0.086 Q13315 H2554D Disease 0.783 0.401 0.02 62 0.882 Q13315 I2702R Disease 0.751 0.835 0.01 66 0.915 Q13315 K1454N Polymorphism 0.501 0.153 0.03 44 0.165 Q13315 L1001Q Disease 0.810 0.241 0.00 41 0.561 Q13315 L1420F Polymorphism 0.811 0.195 0.01 31 0.285 Q13315 L1420P Disease 0.952 0.291 0.00 47 0.643 Q13315 L1465P Disease 0.855 0.310 0.01 43 0.598 Q13315 L1541F Polymorphism 0.720 0.195 0.00 34 0.449 Q13315 L2307F Polymorphism NA 0.121 0.02 33 0.260 Q13315 L2332P Polymorphism 0.762 0.423 0.06 59 0.689 Q13315 L2492R Polymorphism 0.745 0.547 0.01 58 0.894 Q13315 L2656P Disease 0.768 0.709 0.05 48 0.844 Q13315 M1321I Polymorphism 0.265 0.079 0.14 19 0.085 Q13315 N1650S Polymorphism 0.173 0.090 1.00 -19 0.037 Q13315 P1054R Polymorphism 0.869 0.245 0.00 40 0.606 Q13315 P1382S Polymorphism 0.622 0.074 0.24 35 0.094 Q13315 P1566R Disease 0.837 0.312 0.00 49 0.616 Q13315 P2829L Disease 0.904 0.701 0.00 39 0.844 Q13315 R2034Q Polymorphism 0.643 0.257 0.50 41 0.456 Q13315 R2227C Disease 0.908 0.779 0.00 63 0.928 Q13315 R2719H Polymorphism 0.667 0.403 0.12 57 0.635 Q13315 R2832C Disease 0.940 0.784 0.01 56 0.929 Q13315 R2849P Disease 0.871 0.942 0.00 70 0.941 Q13315 R2909G Disease 0.875 0.878 0.00 55 0.937 Q13315 R3008C Disease 0.907 0.695 0.00 48 0.857 Q13315 S1691R Disease 0.364 0.138 0.26 42 0.255 Q13315 S2218C Disease 0.858 0.263 0.00 34 0.574 Q13315 S2855R Disease 0.931 0.916 0.00 63 0.945 Q13315 T1743I Disease NA 0.172 0.04 43 0.288 Q13315 T2335K Polymorphism 0.493 0.272 0.15 48 0.386 Q13315 T2438I Polymorphism 0.447 0.148 0.07 44 0.270 Q13315 T2640I Polymorphism 0.170 0.239 0.13 41 0.316 Q13315 V1570A Polymorphism 0.569 0.113 0.21 -15 0.094 Q13315 V1729L Polymorphism 0.586 0.131 0.30 39 0.140 Q13315 V1913G Disease 0.788 0.210 0.00 32 0.492 Q13315 V2079I Polymorphism 0.504 0.167 0.09 13 0.246 Q13315 V2424G Disease 0.700 0.182 0.05 48 0.370 Q13315 W2491R Disease 0.942 0.794 0.00 64 0.937 Q13315 Y1475C Polymorphism 0.820 0.182 0.00 38 0.371 Q13315 Y1961C Polymorphism NA 0.332 0.03 34 0.429 Q13315 Y2470D Disease 0.446 0.797 0.00 66 0.879 Q13316 R272H Polymorphism 0.536 0.229 0.61 0 0.394 Q13322 P36L Polymorphism NA 0.085 NA -6 0.062 Q13323 E19K Polymorphism NA 0.169 NA 39 0.185 Q13323 L148P Polymorphism NA 0.600 NA 42 0.327 Q13324 E220D Polymorphism 0.104 0.741 0.64 0 0.244 Q13326 G69D Disease 0.898 0.964 0.62 46 0.889 Q13326 G69R Disease 0.925 0.969 0.03 50 0.934 Q13326 C283Y Disease 0.891 0.963 0.00 65 0.950 Q13326 R116H Polymorphism 0.720 0.771 0.13 53 0.875 Q13336 M167V Polymorphism 0.336 0.140 1.00 -8 0.079 Q13336 W171R Polymorphism 0.461 0.925 0.00 48 0.740 Q13342 E516K Polymorphism 0.150 0.048 1.00 -2 0.029 Q13351 F182L Polymorphism 0.162 0.152 0.46 2 0.118 Q13351 S102P Polymorphism NA 0.097 0.13 -1 0.016 Q13352 I30V Polymorphism NA 0.086 0.61 16 0.069 Q13360 D94G Polymorphism 0.263 0.349 0.50 30 0.233 Q13360 T112M Polymorphism 0.615 0.517 0.13 13 0.636 Q13368 R585G Polymorphism NA 0.222 0.00 22 0.405 Q13370 A87V Polymorphism NA 0.180 0.02 -33 0.038 Q13371 K218N Polymorphism 0.259 0.285 0.37 -17 0.290 Q13393 V1024I Polymorphism 0.067 0.060 0.23 -6 0.099 Q13395 A425T Polymorphism NA 0.145 NA 34 0.125 Q13395 S678G Polymorphism NA 0.043 NA -14 0.067 Q13395 I1461V Polymorphism NA 0.050 0.00 -5 0.172 Q13395 T1038I Polymorphism NA 0.071 NA -28 0.062 Q13398 D110N Polymorphism NA 0.552 0.33 15 0.361 Q13402 A26E Disease 0.621 0.557 0.06 28 0.522 Q13402 G25R Disease 0.529 0.753 0.03 44 0.827 Q13402 L16S Disease NA 0.173 0.83 -18 0.096 Q13402 R90P Disease 0.588 0.728 0.07 24 0.786 Q13402 V67M Disease 0.673 0.494 0.03 44 0.711 Q13402 A198T Disease 0.708 0.940 0.01 34 0.817 Q13402 A397D Disease 0.858 0.940 0.01 48 0.894 Q13402 A457V Disease 0.769 0.464 0.00 -8 0.603 Q13402 A826T Disease 0.289 0.459 0.27 12 0.374 Q13402 E450Q Disease 0.805 0.718 0.00 20 0.860 Q13402 E602K Polymorphism 0.197 0.264 0.55 -5 0.194 Q13402 E968D Disease NA 0.224 0.40 -41 0.230 Q13402 G163R Disease 0.999 0.906 0.00 58 0.940 Q13402 G214R Disease 0.925 0.766 0.00 62 0.919 Q13402 G519D Disease 0.896 0.821 0.01 47 0.865 Q13402 G722R Disease 0.999 0.878 0.00 47 0.889 Q13402 G955S Disease NA 0.162 0.19 -55 0.143 Q13402 H133D Disease 0.998 0.951 0.00 70 0.940 Q13402 I134N Disease 0.911 0.863 0.00 40 0.869 Q13402 I205V Polymorphism 0.138 0.025 0.63 -21 0.072 Q13402 K164R Disease 0.995 0.851 0.00 45 0.900 Q13402 L651P Disease 0.922 0.888 0.02 48 0.892 Q13402 M599I Disease 0.379 0.123 0.49 18 0.260 Q13402 N458I Disease 0.999 0.874 0.00 14 0.888 Q13402 P503L Disease 0.605 0.896 0.03 8 0.843 Q13402 R212C Disease 0.952 0.891 0.00 55 0.922 Q13402 R212H Disease 0.888 0.860 0.00 50 0.917 Q13402 R241C Disease 0.952 0.921 0.00 67 0.927 Q13402 R241S Disease 0.840 0.903 0.00 58 0.923 Q13402 R244P Disease 0.554 0.858 0.26 32 0.852 Q13402 R302H Disease NA 0.436 0.11 29 0.506 Q13402 R756W Disease 0.963 0.952 0.01 67 0.940 Q13402 R853C Disease NA 0.912 0.06 13 0.797 Q13402 T165M Disease 0.913 0.933 0.00 55 0.924 Q13402 T204A Disease 0.996 0.850 0.00 53 0.936 Q13402 V597I Polymorphism 0.080 0.087 0.21 -56 0.121 Q13402 A1288P Disease 0.499 0.824 0.18 38 0.801 Q13402 A1628S Disease NA 0.115 0.70 -23 0.159 Q13402 C1666S Polymorphism 0.220 0.595 0.55 8 0.375 Q13402 E1170K Disease 0.738 0.938 0.00 46 0.889 Q13402 E1327K Disease 0.759 0.864 0.00 20 0.835 Q13402 F1992I Polymorphism NA 0.527 0.04 51 0.620 Q13402 G1740S Polymorphism 0.102 0.294 0.76 -38 0.204 Q13402 G2137E Disease NA 0.956 0.01 66 0.928 Q13402 G2163S Disease NA 0.799 0.33 20 0.534 Q13402 G2187D Disease NA 0.822 0.33 44 0.811 Q13402 L1087P Disease 0.469 0.566 0.03 36 0.529 Q13402 L1858P Disease 0.852 0.952 0.00 60 0.948 Q13402 P1887L Disease 0.910 0.951 0.00 41 0.908 Q13402 R1240Q Disease 0.777 0.915 0.00 32 0.872 Q13402 R1343S Disease 0.639 0.703 0.01 13 0.776 Q13402 R1602Q Disease NA 0.277 0.03 5 0.368 Q13402 R1743W Disease 0.735 0.354 0.01 18 0.603 Q13402 R1873W Disease 0.963 0.888 0.01 53 0.949 Q13402 R1883Q Disease 0.789 0.930 0.00 49 0.937 Q13402 T1566M Disease NA 0.102 0.00 -14 0.162 Q13402 Y1719C Disease 0.633 0.472 0.18 -22 0.625 Q13415 R19S Polymorphism NA 0.231 0.42 37 0.244 Q13415 A372V Polymorphism NA 0.091 0.13 26 0.099 Q13415 C469Y Polymorphism NA 0.187 1.00 25 0.346 Q13415 K456E Polymorphism NA 0.204 0.01 48 0.372 Q13415 M816T Polymorphism 0.238 0.310 0.43 18 0.290 Q13415 Q180H Polymorphism NA 0.091 0.00 3 0.149 Q13415 T466M Polymorphism NA 0.245 0.34 13 0.371 Q13416 M106K Polymorphism 0.217 0.367 0.07 38 0.486 Q13421 G497E Polymorphism 0.657 0.308 0.26 46 0.551 Q13421 M601V Polymorphism 0.181 0.029 1.00 -10 0.015 Q13421 R309P Polymorphism 0.232 0.334 0.31 44 0.477 Q13424 L364F Polymorphism 0.632 0.681 0.18 38 0.687 Q13426 A56T Polymorphism NA 0.256 NA 42 0.417 Q13426 A247S Polymorphism NA 0.070 NA 0 0.087 Q13426 E142Q Polymorphism NA 0.082 NA -18 0.092 Q13426 I134T Polymorphism NA 0.212 NA -29 0.196 Q13426 Q240P Polymorphism NA 0.059 NA -13 0.013 Q13427 D445E Polymorphism NA 0.183 1.00 16 0.043 Q13427 N699D Polymorphism NA 0.123 0.01 22 0.115 Q13428 W53R Disease 0.774 0.896 NA 41 0.862 Q13428 A221P Polymorphism 0.348 0.125 0.06 -27 0.081 Q13428 P516L Polymorphism 0.558 0.293 0.00 22 0.419 Q13428 P1176R Polymorphism 0.697 0.158 0.04 33 0.341 Q13438 R398W Polymorphism 0.833 0.227 0.00 25 0.455 Q13438 S454L Polymorphism 0.223 0.172 0.02 -11 0.251 Q13439 Q1028K Polymorphism NA 0.105 0.78 36 0.092 Q13454 I65V Polymorphism 0.150 0.099 1.00 -35 0.099 Q13461 S300G Polymorphism NA 0.136 0.74 9 0.029 Q13464 S108N Polymorphism 0.292 0.188 0.81 -23 0.181 Q13464 T773S Polymorphism 0.193 0.131 0.33 -36 0.118 Q13464 Q1217E Polymorphism 0.146 0.108 0.10 -17 0.153 Q13464 T1112P Polymorphism 0.406 0.160 0.29 9 0.241 Q13465 P120S Polymorphism 0.057 0.058 0.73 -7 0.053 Q13467 P216L Polymorphism 0.570 0.487 0.35 31 0.519 Q13469 H446R Polymorphism 0.414 0.623 0.35 47 0.558 Q13470 R539C Polymorphism NA 0.123 0.01 42 0.112 Q13470 S546C Polymorphism NA 0.094 0.04 20 0.124 Q13470 T514K Polymorphism NA 0.093 0.78 2 0.054 Q13470 V278I Polymorphism 0.150 0.148 0.41 -6 0.176 Q13472 D742N Polymorphism 0.490 0.186 0.65 -24 0.144 Q13472 N773D Polymorphism 0.437 0.109 0.55 40 0.257 Q13474 V68L Polymorphism NA 0.084 NA -4 0.039 Q13477 P300H Polymorphism 0.089 0.050 0.04 34 0.073 Q13478 N232K Polymorphism 0.147 0.267 0.89 8 0.163 Q13478 S310N Polymorphism 0.139 0.207 0.28 19 0.203 Q13485 E330G Disease 0.916 0.968 0.00 43 0.915 Q13485 G352R Disease 0.975 0.908 0.08 60 0.946 Q13485 G386D Disease 0.966 0.925 0.00 59 0.952 Q13485 R361C Disease 0.895 0.963 0.01 67 0.943 Q13485 W101G Polymorphism 0.937 0.970 0.00 40 0.922 Q13487 L118V Polymorphism NA 0.072 NA 16 0.117 Q13488 A141P Disease NA 0.850 0.22 6 0.576 Q13488 D517N Disease 0.940 0.978 0.06 51 0.938 Q13488 G405R Disease 0.982 0.962 0.01 54 0.954 Q13488 P161L Polymorphism NA 0.606 0.32 -17 0.472 Q13488 P775R Disease 0.354 0.603 0.37 7 0.584 Q13488 R444L Disease 0.970 0.931 0.00 61 0.958 Q13489 R401K Polymorphism 0.135 0.193 0.41 -9 0.185 Q13490 M453V Polymorphism 0.087 0.081 0.33 16 0.097 Q13492 F641L Polymorphism 0.167 0.157 0.00 18 0.284 Q13492 Q579E Polymorphism 0.079 0.416 0.16 2 0.302 Q13492 S383F Polymorphism 0.464 0.255 0.66 2 0.389 Q13495 Q580R Polymorphism 0.384 0.079 0.18 8 0.055 Q13496 L70F Disease 0.475 0.748 0.01 19 0.604 Q13496 L87P Disease 0.874 0.966 0.07 62 0.946 Q13496 R69C Disease 0.848 0.942 0.01 61 0.939 Q13496 R69P Disease 0.662 0.965 0.07 44 0.878 Q13496 R69S Disease 0.474 0.876 0.07 41 0.849 Q13496 V49F Disease 0.665 0.624 0.00 54 0.730 Q13496 Y68D Disease 0.837 0.835 0.08 63 0.915 Q13496 A279G Disease 0.615 0.887 0.04 45 0.886 Q13496 A389D Disease 0.641 0.829 0.01 47 0.877 Q13496 C444Y Disease 0.789 0.923 0.00 49 0.913 Q13496 D431N Disease 0.620 0.562 0.28 -13 0.493 Q13496 D433N Disease 0.403 0.647 0.05 10 0.513 Q13496 E157K Disease NA 0.802 0.59 26 0.557 Q13496 E404K Disease 0.223 0.584 0.19 12 0.362 Q13496 G378E Disease 0.994 0.926 0.00 73 0.954 Q13496 G378R Disease 0.995 0.886 0.00 76 0.951 Q13496 G402A Disease 0.993 0.871 0.00 60 0.955 Q13496 G402R Disease 0.997 0.887 0.00 72 0.954 Q13496 G402V Disease 0.997 0.883 0.00 65 0.955 Q13496 H232R Disease 0.426 0.731 0.01 58 0.831 Q13496 H374D Disease 0.990 0.778 0.00 71 0.943 Q13496 H469P Disease 0.630 0.892 0.01 72 0.914 Q13496 I225T Disease 0.525 0.736 0.01 43 0.829 Q13496 I264S Disease 0.760 0.677 0.02 31 0.794 Q13496 K510N Disease 0.179 0.256 0.40 9 0.236 Q13496 L202S Disease 0.503 0.777 0.00 25 0.832 Q13496 L228P Disease 0.882 0.923 0.00 45 0.906 Q13496 L391P Disease 0.846 0.896 0.00 55 0.926 Q13496 L406P Disease 0.866 0.960 0.00 66 0.944 Q13496 L470P Disease 0.866 0.760 0.06 49 0.890 Q13496 M317R Disease 0.692 0.782 0.00 58 0.902 Q13496 N180K Disease 0.367 0.500 0.05 2 0.484 Q13496 N189S Disease 0.611 0.822 0.00 70 0.885 Q13496 N481Y Disease 0.761 0.760 0.00 67 0.911 Q13496 P179S Disease 0.450 0.385 0.25 -4 0.287 Q13496 P199S Disease 0.747 0.860 0.00 47 0.752 Q13496 P205L Disease 0.838 0.893 0.00 20 0.892 Q13496 P226T Disease 0.994 0.857 0.00 52 0.946 Q13496 R184G Disease 0.624 0.827 0.01 57 0.904 Q13496 R184L Disease 0.563 0.858 0.01 54 0.891 Q13496 R241C Disease 0.996 0.964 0.00 77 0.953 Q13496 R241L Disease 0.992 0.939 0.00 68 0.956 Q13496 R421Q Disease 0.994 0.899 0.00 73 0.951 Q13496 S229P Disease 0.692 0.822 0.06 33 0.853 Q13496 S376N Disease 0.671 0.797 0.01 47 0.872 Q13496 T186I Disease 0.345 0.579 0.00 42 0.638 Q13496 T197I Disease 0.644 0.779 0.00 38 0.858 Q13496 V227M Disease 0.715 0.584 0.01 34 0.771 Q13496 V364G Disease 0.804 0.703 0.00 39 0.845 Q13496 W230C Disease 0.934 0.857 0.00 62 0.936 Q13496 W346C Disease 0.998 0.872 0.00 65 0.955 Q13496 W346S Disease 0.997 0.828 0.00 65 0.951 Q13496 W411C Disease 0.998 0.941 0.00 59 0.958 Q13496 W499R Disease 0.850 0.877 0.00 74 0.935 Q13496 Y198N Disease 0.992 0.897 0.00 60 0.951 Q13496 Y397C Disease 0.902 0.896 0.00 37 0.833 Q13501 G411S Disease 0.301 0.677 0.03 17 0.677 Q13501 G425R Disease 0.307 0.756 0.01 37 0.694 Q13501 M404T Disease 0.293 0.526 0.00 23 0.682 Q13501 M404V Disease 0.282 0.433 0.00 14 0.570 Q13501 P387L Disease 0.308 0.522 0.00 -24 0.442 Q13501 P392L Disease 0.636 0.468 0.01 -22 0.502 Q13501 S399P Disease 0.636 0.363 0.02 8 0.590 Q13508 S363L Polymorphism NA 0.333 NA 47 0.201 Q13510 A70V Polymorphism NA 0.340 0.31 25 0.385 Q13510 H23D Disease NA 0.137 0.82 3 0.083 Q13510 I93V Polymorphism NA 0.097 1.00 -25 0.103 Q13510 Q22H Disease NA 0.325 0.03 43 0.482 Q13510 V97E Disease NA 0.623 0.00 33 0.737 Q13510 Y36C Disease NA 0.725 0.13 54 0.837 Q13510 D124E Polymorphism NA 0.297 0.23 -21 0.192 Q13510 E138V Disease NA 0.862 0.00 61 0.900 Q13510 G235R Disease NA 0.749 0.30 42 0.788 Q13510 L182V Disease NA 0.591 0.00 56 0.713 Q13510 N320D Disease NA 0.901 0.00 75 0.901 Q13510 P362R Disease NA 0.827 0.02 48 0.834 Q13510 R254G Disease NA 0.948 0.00 63 0.928 Q13510 T222K Disease NA 0.655 0.03 66 0.767 Q13510 V369I Polymorphism NA 0.101 0.88 -16 0.147 Q13515 R287W Disease 0.816 0.884 0.00 40 0.869 Q13520 V234I Polymorphism NA 0.097 0.78 -48 0.131 Q13535 T64A Polymorphism NA 0.092 0.07 -2 0.037 Q13535 K297N Polymorphism 0.382 0.123 0.00 30 0.170 Q13535 V316I Polymorphism 0.324 0.282 0.00 20 0.155 Q13535 I1526V Polymorphism 0.410 0.170 0.42 4 0.145 Q13535 N1612S Polymorphism 0.306 0.115 0.73 -29 0.113 Q13535 P2434A Polymorphism 0.791 0.353 0.00 23 0.620 Q13535 S1213G Polymorphism 0.499 0.215 0.68 1 0.211 Q13535 Y1087H Polymorphism 0.561 0.191 0.54 12 0.258 Q13535 Y2132D Polymorphism 0.619 0.297 0.66 26 0.485 Q13546 A438V Polymorphism 0.242 0.097 0.05 7 0.089 Q13546 A443V Polymorphism 0.246 0.104 0.03 24 0.117 Q13546 A569V Polymorphism 0.283 0.135 0.16 6 0.122 Q13546 E234K Polymorphism 0.206 0.282 0.47 48 0.302 Q13555 S36P Polymorphism NA 0.827 0.00 9 0.575 Q13557 D167E Polymorphism 0.123 0.464 0.99 -24 0.216 Q13557 Q463E Polymorphism 0.247 0.523 0.02 40 0.520 Q13562 P197H Polymorphism 0.810 0.295 0.03 34 0.572 Q13562 R111L Disease 0.997 0.928 0.00 46 0.939 Q13563 R28P Polymorphism NA 0.286 0.00 39 0.204 Q13563 A190T Polymorphism 0.284 0.086 0.02 12 0.120 Q13563 A356P Disease 0.534 0.892 0.02 10 0.824 Q13563 C632R Disease 0.789 0.797 0.01 60 0.902 Q13563 D511V Disease 0.894 0.873 0.00 49 0.892 Q13563 F482C Polymorphism 0.565 0.799 0.05 9 0.826 Q13563 I452V Polymorphism 0.166 0.265 0.27 10 0.249 Q13563 R306Q Disease 0.246 0.545 0.02 -1 0.340 Q13563 R322Q Disease 0.865 0.955 0.00 53 0.862 Q13563 R322W Disease 0.976 0.975 0.00 60 0.951 Q13563 R420G Disease NA 0.959 0.00 60 0.892 Q13563 R807Q Disease 0.316 0.155 0.16 31 0.128 Q13563 W414G Disease 0.926 0.963 0.00 73 0.947 Q13569 V367L Polymorphism 0.108 0.041 NA -4 0.049 Q13571 R226K Polymorphism 0.079 0.047 0.71 14 0.038 Q13576 P479R Polymorphism 0.424 0.602 0.00 30 0.601 Q13576 R714W Polymorphism NA 0.187 0.03 -1 0.381 Q13576 T894I Polymorphism 0.703 0.889 0.03 22 0.857 Q13576 V455A Polymorphism 0.113 0.034 0.02 -49 0.077 Q13576 R1052I Polymorphism 0.565 0.575 0.41 8 0.471 Q13576 R1379W Polymorphism 0.683 0.328 0.01 20 0.617 Q13596 D466N Polymorphism 0.479 0.182 0.07 -4 0.270 Q13601 R134Q Polymorphism 0.466 0.286 0.32 2 0.401 Q13606 R6G Polymorphism 0.095 0.456 0.50 12 0.199 Q13606 F76S Polymorphism 0.223 0.116 1.00 -51 0.099 Q13608 A924S Polymorphism 0.157 0.494 0.42 -58 0.136 Q13608 N849T Disease 0.787 0.756 0.00 63 0.801 Q13608 P274L Disease NA 0.256 0.00 15 0.385 Q13608 P939Q Polymorphism 0.145 0.330 0.59 -26 0.296 Q13608 R601Q Polymorphism 0.977 0.924 0.00 67 0.954 Q13608 R812Q Disease 0.772 0.857 0.00 68 0.934 Q13608 R812W Disease 0.959 0.902 0.00 67 0.976 Q13608 R860Q Disease 0.969 0.851 0.00 74 0.980 Q13608 R860W Disease 0.994 0.898 0.00 72 0.990 Q13608 V882I Polymorphism 0.143 0.317 1.00 -27 0.148 Q13609 N96K Polymorphism 0.115 0.539 0.30 2 0.151 Q13610 L288F Polymorphism 0.400 0.552 0.01 24 0.611 Q13614 N545S Polymorphism 0.597 0.288 0.64 10 0.584 Q13614 R283W Disease 0.997 0.952 0.00 43 0.939 Q13617 N109S Polymorphism NA 0.671 0.00 -23 0.572 Q13618 D13H Polymorphism NA 0.137 0.21 9 0.228 Q13618 R184S Polymorphism NA 0.678 0.68 9 0.446 Q13618 V567I Polymorphism NA 0.080 0.56 -1 0.133 Q13621 D648N Disease 0.538 0.711 0.02 -7 0.569 Q13621 V272F Disease NA 0.743 0.03 1 0.604 Q13627 Q681H Polymorphism NA 0.272 0.01 45 0.274 Q13635 A393T Disease 0.348 0.322 0.60 -8 0.254 Q13635 A443G Disease 0.381 0.793 0.09 -4 0.560 Q13635 D513Y Disease 0.951 0.968 0.05 0 0.897 Q13635 F376S Disease 0.732 0.582 0.05 42 0.748 Q13635 G509R Disease 0.940 0.949 0.02 46 0.915 Q13635 G509V Disease 0.935 0.890 0.08 -12 0.895 Q13635 L175P Disease NA 0.930 0.00 40 0.779 Q13635 S827G Disease 0.240 0.135 0.42 42 0.149 Q13635 T230P Disease 0.688 0.831 0.01 46 0.859 Q13635 T728M Disease 0.334 0.069 0.26 45 0.097 Q13635 V751G Disease 0.255 0.364 0.33 31 0.329 Q13635 V908G Disease 0.899 0.508 0.02 51 0.870 Q13635 E1438D Disease 0.123 0.333 0.00 -12 0.171 Q13635 G1069R Disease 0.864 0.975 0.01 56 0.946 Q13635 P1282L Polymorphism 0.192 0.133 0.48 23 0.108 Q13635 P1315L Polymorphism 0.061 0.215 0.00 23 0.301 Q13635 S1132P Disease 0.651 0.941 0.08 48 0.892 Q13635 S1132Y Disease 0.810 0.881 0.02 29 0.887 Q13635 T1052M Disease 0.760 0.404 0.11 40 0.645 Q13635 T1195S Polymorphism 0.257 0.146 0.53 9 0.139 Q13639 C372Y Polymorphism 0.430 0.316 0.07 53 0.384 Q13642 C132F Disease 0.999 0.217 0.00 72 0.917 Q13642 C153R Disease 0.946 0.202 0.13 54 0.547 Q13642 C153Y Disease 0.961 0.214 0.10 65 0.749 Q13642 C224W Disease 0.999 0.934 0.00 75 0.948 Q13642 H123Y Disease 0.874 0.233 0.00 64 0.929 Q13642 W122S Disease 0.876 0.194 0.00 64 0.668 Q13651 L61V Polymorphism 0.341 0.105 0.20 6 0.092 Q13651 S159G Polymorphism 0.233 0.109 0.10 13 0.101 Q13651 S420L Polymorphism 0.561 0.105 NA 17 0.049 Q13698 R528G Disease 0.989 0.877 0.00 39 0.930 Q13698 R528H Disease 0.994 0.843 0.00 31 0.936 Q13698 R900S Disease 0.993 0.888 0.00 42 0.944 Q13698 E1840D Polymorphism 0.086 0.148 0.56 -15 0.114 Q13698 R1086H Disease 0.918 0.693 0.00 25 0.871 Q13698 R1239G Disease 0.990 0.863 0.00 39 0.941 Q13698 R1239H Disease 0.995 0.926 0.00 46 0.941 Q13698 R1658H Polymorphism 0.434 0.198 0.26 14 0.205 Q13702 L14P Disease NA 0.519 0.27 62 0.812 Q13702 N88K Disease 0.156 0.927 0.00 53 0.838 Q13702 V45M Disease 0.571 0.200 0.10 -6 0.412 Q13702 A189V Disease 0.482 0.668 0.28 34 0.623 Q13702 E162K Disease 0.464 0.962 0.50 53 0.851 Q13702 F139S Disease 0.345 0.760 0.02 47 0.701 Q13702 L283P Disease 0.733 0.880 0.03 54 0.678 Q13702 R164C Disease 0.724 0.359 0.00 51 0.607 Q13705 R40H Disease NA 0.273 0.12 47 0.413 Q13705 E459D Polymorphism 0.191 0.683 0.13 26 0.435 Q13705 P176R Polymorphism 0.588 0.319 0.26 24 0.565 Q13705 V494I Disease 0.144 0.103 0.12 12 0.113 Q13724 F652L Disease 0.368 0.571 0.08 15 0.648 Q13724 G222R Polymorphism 0.129 0.696 0.03 18 0.305 Q13724 G785S Polymorphism 0.210 0.114 0.73 -10 0.103 Q13724 R486T Disease 0.893 0.938 0.00 53 0.939 Q13724 R495P Polymorphism 0.707 0.971 0.03 53 0.907 Q13733 G83D Polymorphism 0.496 0.129 0.89 8 0.094 Q13733 M541R Polymorphism 0.197 0.740 0.16 9 0.342 Q13733 M586I Polymorphism 0.138 0.370 0.56 -22 0.162 Q13740 L315M Polymorphism 0.523 0.242 0.07 26 0.557 Q13740 M367I Polymorphism 0.158 0.167 0.35 7 0.154 Q13740 N258S Polymorphism 0.116 0.169 1.00 -13 0.124 Q13740 T301M Polymorphism 0.379 0.444 0.04 45 0.527 Q13740 V352M Polymorphism 0.643 0.237 0.15 49 0.508 Q13748 V75L Polymorphism NA 0.272 0.26 -7 0.276 Q13748 V440M Polymorphism 0.121 0.162 0.26 -23 0.165 Q13751 A926D Polymorphism NA 0.230 0.57 32 0.350 Q13751 E210K Disease 0.281 0.525 NA 17 0.493 Q13751 G199A Disease 0.074 0.235 NA -14 0.199 Q13751 K207Q Disease 0.295 0.137 NA 26 0.283 Q13751 M852L Polymorphism NA 0.199 0.30 -15 0.192 Q13751 N181D Polymorphism 0.269 0.166 NA 15 0.228 Q13751 N690S Polymorphism NA 0.298 0.73 -20 0.260 Q13751 P679L Disease NA 0.106 0.32 15 0.172 Q13751 R292L Polymorphism 0.410 0.307 0.02 45 0.454 Q13751 V527M Polymorphism 0.437 0.472 0.08 8 0.343 Q13753 A111P Polymorphism 0.084 0.206 0.33 -4 0.122 Q13753 D136V Polymorphism NA 0.426 0.35 32 0.433 Q13753 S608I Polymorphism 0.160 0.187 0.01 22 0.309 Q13753 S733T Polymorphism 0.086 0.091 0.44 34 0.135 Q13769 T475S Polymorphism 0.195 0.104 0.51 -12 0.165 Q13769 V579I Polymorphism 0.134 0.035 0.44 -46 0.025 Q13796 D942E Polymorphism NA 0.125 0.83 12 0.101 Q13796 L1607F Polymorphism 0.079 0.085 0.59 -8 0.085 Q13813 I1300T Polymorphism 0.172 0.182 0.25 15 0.235 Q13823 Q452H Polymorphism 0.416 0.803 0.14 -14 0.493 Q13825 A240V Disease 0.964 0.711 0.00 50 0.920 Q13835 C161Y Polymorphism NA 0.380 0.00 34 0.185 Q13835 I196V Polymorphism NA 0.036 0.98 -37 0.013 Q13873 C60Y Disease NA 0.940 0.01 58 0.913 Q13873 Q82H Disease NA 0.318 0.00 44 0.435 Q13873 C117Y Disease NA 0.977 0.02 68 0.929 Q13873 C118W Disease NA 0.962 0.01 68 0.930 Q13873 C123R Disease NA 0.969 0.00 75 0.936 Q13873 C123S Disease NA 0.973 0.02 55 0.904 Q13873 C347Y Disease 0.893 0.843 0.00 54 0.912 Q13873 C420R Disease 0.971 0.902 0.38 58 0.977 Q13873 C483R Disease 0.969 0.920 0.00 75 0.952 Q13873 D485G Disease 0.908 0.658 0.02 35 0.815 Q13873 G182D Disease 0.418 0.570 0.06 0 0.442 Q13873 K512T Disease 0.415 0.327 0.02 25 0.272 Q13873 N519K Disease 0.336 0.300 0.11 37 0.255 Q13873 R491Q Disease 0.983 0.899 0.00 73 0.956 Q13873 R491W Disease 0.996 0.927 0.00 73 0.958 Q13873 R899P Disease NA 0.487 NA -5 0.296 Q13882 A436T Polymorphism 0.175 0.070 0.52 -55 0.093 Q13888 I151M Polymorphism 0.109 0.064 1.00 -68 0.032 Q13888 V236L Polymorphism 0.167 0.454 0.28 5 0.231 Q13895 E103K Polymorphism 0.196 0.325 0.27 23 0.351 Q13901 S127P Polymorphism 0.360 0.114 0.40 -26 0.040 Q13936 A39V Disease NA 0.327 0.06 -18 0.473 Q13936 Q84R Polymorphism NA 0.227 0.31 41 0.398 Q13936 A752T Polymorphism 0.939 0.365 0.21 -12 0.617 Q13936 G402S Disease 0.975 0.766 0.00 -4 0.840 Q13936 G406R Disease 0.988 0.654 0.02 16 0.818 Q13936 G490R Disease 0.413 0.560 0.41 15 0.427 Q13936 M1869V Polymorphism NA 0.097 0.33 0 0.079 Q13939 S75N Polymorphism NA 0.374 0.57 -12 0.202 Q13946 G76E Polymorphism NA 0.270 0.04 45 0.358 Q13948 I545V Polymorphism 0.101 0.050 1.00 -1 0.051 Q13950 C123R Disease 0.855 0.984 0.00 68 0.934 Q13950 F121C Disease 0.797 0.952 0.00 47 0.890 Q13950 F197S Disease 0.947 0.987 0.00 41 0.900 Q13950 G511S Disease 0.483 0.403 0.10 -9 0.422 Q13950 L113R Disease 0.822 0.990 0.00 57 0.930 Q13950 L199F Disease 0.693 0.888 0.00 37 0.857 Q13950 M175R Disease 0.546 0.946 0.00 58 0.911 Q13950 Q209R Disease 0.359 0.930 0.00 34 0.782 Q13950 R169Q Disease 0.917 0.876 0.00 58 0.941 Q13950 R190Q Disease 0.917 0.942 0.00 67 0.944 Q13950 R190W Disease 0.985 0.965 0.00 67 0.959 Q13950 R193C Disease 0.980 0.985 0.00 68 0.955 Q13950 R225Q Disease 0.914 0.939 0.00 52 0.940 Q13950 R225W Disease 0.985 0.966 0.00 52 0.963 Q13950 S118R Disease 0.917 0.988 0.01 63 0.940 Q13950 S191N Disease 0.912 0.912 0.00 58 0.941 Q13950 T200A Disease 0.749 0.904 0.00 42 0.858 Q13950 T205R Disease 0.818 0.978 0.00 58 0.935 Q13976 N267S Polymorphism NA 0.106 0.58 -21 0.130 Q14002 A263V Polymorphism 0.342 0.513 0.00 -65 0.468 Q14002 F120I Polymorphism 0.383 0.304 0.40 -20 0.296 Q14002 Y236H Polymorphism 0.609 0.872 0.15 31 0.698 Q14003 F448L Disease 0.428 0.666 1.00 -32 0.381 Q14003 R420H Disease 0.756 0.876 0.00 57 0.923 Q14004 L403F Polymorphism NA 0.154 0.01 30 0.140 Q14004 P356A Polymorphism NA 0.128 0.02 24 0.164 Q14004 R700L Polymorphism 0.176 0.815 0.00 46 0.538 Q14004 T494A Polymorphism NA 0.136 0.06 23 0.122 Q14004 T670R Polymorphism 0.170 0.152 0.07 44 0.292 Q14005 P434S Polymorphism NA 0.182 0.81 24 0.133 Q14005 S1027T Polymorphism 0.086 0.040 0.58 -7 0.046 Q14008 Y785C Polymorphism 0.741 0.500 0.14 27 0.655 Q14012 E361K Polymorphism NA 0.145 0.89 41 0.133 Q14028 A961S Polymorphism 0.214 0.544 0.31 41 0.339 Q14028 L479I Polymorphism NA 0.168 0.06 16 0.150 Q14028 L745I Polymorphism 0.175 0.454 0.53 -24 0.199 Q14028 R100H Polymorphism NA 0.103 0.02 11 0.139 Q14031 S455A Polymorphism NA 0.202 0.58 -8 0.170 Q14031 S455P Polymorphism NA 0.221 0.60 -62 0.177 Q14031 I1162V Polymorphism 0.167 0.493 0.35 14 0.151 Q14031 L1362P Polymorphism NA 0.331 0.34 -25 0.308 Q14031 N1110K Polymorphism 0.175 0.615 0.42 7 0.162 Q14031 P1126S Polymorphism 0.246 0.408 0.38 29 0.352 Q14032 M76V Disease NA 0.929 0.00 67 0.930 Q14032 R20Q Polymorphism NA 0.113 0.53 11 0.194 Q14050 A435E Polymorphism 0.227 0.288 0.95 6 0.189 Q14050 R103Q Polymorphism 0.287 0.536 0.20 -12 0.239 Q14050 R402Q Polymorphism 0.472 0.265 0.28 2 0.285 Q14055 L335V Polymorphism 0.187 0.192 0.41 6 0.222 Q14055 Q326R Polymorphism 0.082 0.265 0.54 10 0.147 Q14055 Q326W Disease 0.490 0.290 0.02 4 0.390 Q14055 T246M Polymorphism 0.086 0.192 0.13 -19 0.180 Q14088 M102T Polymorphism 0.417 0.658 0.00 59 0.687 Q14093 A319E Polymorphism 0.061 0.088 0.95 8 0.055 Q14093 D146Y Polymorphism 0.099 0.084 0.05 39 0.061 Q14093 G208D Polymorphism 0.337 0.045 0.23 -8 0.031 Q14112 P529S Polymorphism NA 0.804 0.00 21 0.668 Q14112 R866Q Polymorphism 0.095 0.214 0.72 54 0.185 Q14112 V726M Polymorphism 0.180 0.358 0.19 42 0.293 Q14114 D46E Polymorphism 0.300 0.105 1.00 -12 0.101 Q14114 Q25R Polymorphism 0.306 0.219 0.57 -24 0.131 Q14114 I611L Polymorphism 0.648 0.417 0.19 17 0.533 Q14114 Q607R Polymorphism 0.345 0.395 0.35 2 0.020 Q14114 R736Q Polymorphism 0.569 0.119 0.53 23 0.335 Q14114 R952Q Polymorphism NA 0.198 NA 21 0.150 Q14114 W466C Polymorphism 0.995 0.871 0.00 49 0.990 Q14117 T68R Disease 0.858 0.929 0.00 71 0.930 Q14117 G435R Disease 0.875 0.950 0.00 69 0.933 Q14117 Q334R Disease 0.507 0.759 0.01 26 0.687 Q14117 R490T Disease 0.647 0.891 0.00 23 0.824 Q14117 W360R Disease 0.847 0.755 0.00 66 0.923 Q14118 S14W Polymorphism 0.219 0.175 0.95 -25 0.027 Q14126 R46Q Disease 0.830 0.885 0.00 -21 0.858 Q14126 R49H Disease 0.995 0.930 0.00 -13 0.913 Q14126 Y89C Polymorphism 0.759 0.541 0.00 41 0.829 Q14126 C507Y Disease 0.591 0.507 0.05 57 0.778 Q14126 G812C Disease 0.708 0.923 0.00 46 0.876 Q14126 I293V Polymorphism 0.118 0.254 0.33 -2 0.226 Q14126 M863L Polymorphism NA 0.049 1.00 -15 0.021 Q14126 R773K Polymorphism NA 0.277 0.15 15 0.222 Q14126 T903I Polymorphism 0.344 0.183 0.08 6 0.280 Q14126 V515I Polymorphism 0.122 0.132 1.00 -32 0.110 Q14129 A117V Polymorphism 0.358 0.082 1.00 -26 0.066 Q14135 M32I Polymorphism NA 0.136 NA 16 0.039 Q14145 D349N Polymorphism 0.124 0.648 0.57 21 0.122 Q14146 V778G Polymorphism NA 0.089 NA -22 0.008 Q14147 R17W Polymorphism NA 0.120 0.00 -8 0.046 Q14147 G117D Polymorphism NA 0.237 0.06 -1 0.215 Q14152 E386K Polymorphism 0.466 0.561 0.06 2 0.506 Q14152 K694N Polymorphism 0.364 0.411 0.23 30 0.379 Q14154 G60D Polymorphism 0.151 0.140 1.00 20 0.085 Q14154 A247T Polymorphism 0.139 0.506 0.43 6 0.236 Q14154 R468C Polymorphism NA 0.093 0.05 36 0.104 Q14156 G358R Polymorphism 0.261 0.392 0.11 -4 0.240 Q14157 Q482H Polymorphism 0.524 0.107 0.16 40 0.151 Q14160 P422L Polymorphism 0.062 0.179 0.05 31 0.250 Q14161 A552V Polymorphism 0.222 0.060 0.04 -27 0.109 Q14162 R618K Polymorphism NA 0.131 0.84 -19 0.092 Q14162 R662W Polymorphism NA 0.151 0.03 28 0.170 Q14164 A371T Polymorphism 0.259 0.094 1.00 -16 0.072 Q14164 E515D Polymorphism 0.169 0.089 0.21 -11 0.115 Q14164 G660E Polymorphism 0.761 0.127 0.11 0 0.118 Q14164 P713L Polymorphism 0.062 0.059 0.07 -1 0.044 Q14166 N95S Polymorphism NA 0.049 NA -14 0.075 Q14166 R84W Polymorphism NA 0.121 NA 30 0.255 Q14166 V297M Polymorphism NA 0.087 0.01 4 0.152 Q14166 V464M Polymorphism NA 0.153 0.11 37 0.282 Q14181 G583R Polymorphism 0.190 0.146 0.20 14 0.253 Q14181 S588N Polymorphism 0.265 0.138 0.30 21 0.241 Q14183 G48S Polymorphism 0.188 0.096 0.81 8 0.113 Q14185 A1793T Polymorphism 0.144 0.049 0.76 8 0.072 Q14188 I64T Polymorphism NA 0.628 0.00 -12 0.499 Q14190 L483M Polymorphism 0.236 0.086 0.22 -32 0.081 Q14191 K32R Polymorphism NA 0.276 0.00 20 0.396 Q14191 E343K Polymorphism NA 0.051 0.06 -4 0.045 Q14191 I912S Polymorphism 0.632 0.124 0.21 22 0.367 Q14191 K125N Disease NA 0.337 0.00 43 0.572 Q14191 K135E Disease NA 0.477 0.00 51 0.676 Q14191 L383W Polymorphism NA 0.195 0.06 38 0.302 Q14191 N240K Polymorphism NA 0.154 0.04 23 0.103 Q14191 N533S Polymorphism 0.072 0.162 1.00 -27 0.081 Q14191 Q724L Polymorphism 0.570 0.175 0.38 -9 0.231 Q14191 S708F Polymorphism 0.631 0.735 0.02 16 0.766 Q14191 V114I Polymorphism NA 0.090 0.79 -2 0.042 Q14191 C1367R Polymorphism 0.432 0.534 0.09 39 0.726 Q14191 S1079L Polymorphism 0.331 0.252 0.00 22 0.321 Q14191 S1141L Polymorphism 0.072 0.087 0.03 -26 0.098 Q14194 V461I Polymorphism 0.393 0.249 0.17 4 0.366 Q14195 A442S Polymorphism 0.179 0.411 0.45 -38 0.165 Q14197 R8P Polymorphism NA 0.814 0.00 43 0.572 Q14197 L77F Polymorphism 0.402 0.560 0.09 5 0.508 Q14203 G59S Disease 0.875 0.861 0.00 13 0.881 Q14203 R495Q Polymorphism 0.287 0.070 0.38 -7 0.105 Q14204 D3902N Polymorphism 0.203 0.299 0.22 11 0.310 Q14204 H4029Q Polymorphism 0.134 0.129 0.59 -25 0.099 Q14207 V987A Polymorphism 0.150 0.048 0.11 6 0.065 Q14207 Q1191R Polymorphism 0.091 0.132 0.24 32 0.131 Q14209 G205R Polymorphism 0.350 0.514 0.18 6 0.489 Q14209 Q226H Polymorphism 0.137 0.198 0.26 22 0.253 Q14210 A10T Polymorphism NA 0.104 0.21 -39 0.021 Q14213 V201I Polymorphism 0.058 0.133 0.34 2 0.112 Q14232 N208Y Disease 0.874 0.779 0.04 55 0.925 Q14242 M62I Polymorphism 0.107 0.049 0.28 -14 0.030 Q14244 R558W Polymorphism 0.742 0.186 0.02 34 0.439 Q14246 R2L Polymorphism NA 0.251 0.46 -80 0.109 Q14246 D174N Polymorphism NA 0.523 0.65 11 0.383 Q14246 F691C Polymorphism 0.905 0.835 0.00 53 0.901 Q14246 N254S Polymorphism NA 0.316 0.80 -3 0.288 Q14246 S140R Polymorphism NA 0.288 0.40 35 0.403 Q14246 T389M Polymorphism NA 0.290 0.05 7 0.417 Q14246 V724L Polymorphism 0.229 0.584 0.15 18 0.450 Q14264 C192Y Polymorphism 0.666 0.426 NA 45 0.586 Q14264 N569S Polymorphism 0.403 0.203 0.02 23 0.281 Q14264 Y236C Polymorphism 0.740 0.550 NA 36 0.592 Q14289 K838T Polymorphism NA 0.107 0.01 3 0.081 Q14289 L808P Polymorphism NA 0.702 0.00 16 0.553 Q14289 Q359E Polymorphism 0.085 0.115 0.45 -15 0.054 Q14289 R698H Polymorphism 0.301 0.446 0.04 -1 0.398 Q14296 A436V Polymorphism 0.071 0.060 0.18 6 0.039 Q14314 G53E Polymorphism 0.075 0.113 0.05 -2 0.107 Q14315 K2135R Polymorphism 0.130 0.156 0.25 11 0.157 Q14315 R1567Q Polymorphism 0.188 0.712 0.10 52 0.442 Q14315 S2626N Polymorphism 0.162 0.229 0.00 -16 0.264 Q14318 A87V Polymorphism NA 0.224 0.02 24 0.407 Q14324 D282N Polymorphism NA 0.397 0.86 14 0.224 Q14324 G514S Polymorphism NA 0.414 0.06 22 0.331 Q14331 K66E Polymorphism 0.128 0.285 1.00 7 0.174 Q14331 T19A Polymorphism 0.087 0.106 0.66 -14 0.043 Q14344 V221L Polymorphism 0.196 0.888 0.13 4 0.435 Q14353 A54P Disease NA 0.833 0.04 29 0.692 Q14353 H51P Disease NA 0.587 0.17 28 0.710 Q14353 M50L Disease NA 0.753 0.05 55 0.854 Q14353 W20S Disease NA 0.672 0.56 58 0.785 Q14353 C169Y Disease NA 0.718 0.71 16 0.702 Q14353 L197P Disease NA 0.799 0.01 49 0.845 Q14353 T209M Polymorphism NA 0.322 0.24 -12 0.254 Q14376 A25V Disease 0.590 0.500 0.28 26 0.619 Q14376 D69E Disease 0.566 0.784 0.06 37 0.571 Q14376 G90E Disease 0.889 0.951 0.00 60 0.927 Q14376 N34S Disease 0.584 0.896 0.11 56 0.593 Q14376 R40C Disease 0.498 0.844 0.01 57 0.882 Q14376 V94M Disease 0.878 0.940 0.00 65 0.931 Q14376 D103G Disease 0.332 0.186 0.21 4 0.303 Q14376 E165K Disease 0.874 0.952 0.00 61 0.745 Q14376 G302D Disease 0.973 0.848 0.00 57 0.932 Q14376 G319E Disease 0.471 0.907 0.07 36 0.574 Q14376 K257R Disease 0.383 0.245 0.69 -24 0.252 Q14376 L183P Disease 0.974 0.912 0.00 53 0.839 Q14376 L313M Disease 0.481 0.455 0.04 -20 0.500 Q14376 R169W Disease 0.905 0.722 0.01 39 0.791 Q14376 R239W Disease 0.990 0.846 0.00 75 0.840 Q14376 R335H Disease 0.513 0.391 0.16 4 0.571 Q14392 L223V Polymorphism 0.542 0.733 0.06 5 0.363 Q14393 S231Y Polymorphism 0.489 0.382 0.05 41 0.508 Q14393 S623L Polymorphism NA 0.080 0.33 8 0.087 Q14393 V390M Polymorphism NA 0.165 0.15 1 0.129 Q14397 P446L Polymorphism NA 0.135 0.01 39 0.146 Q14397 R540Q Polymorphism NA 0.022 1.00 -40 0.048 Q14432 D12N Polymorphism NA 0.133 0.37 33 0.042 Q14444 A263D Polymorphism 0.186 0.313 0.08 6 0.376 Q14444 Q588H Polymorphism 0.668 0.185 0.56 41 0.394 Q14444 R616H Polymorphism 0.692 0.391 0.55 46 0.472 Q14457 I403T Polymorphism 0.204 0.910 0.01 41 0.708 Q14494 D63H Polymorphism NA 0.557 NA 56 0.748 Q14498 A2V Polymorphism NA 0.264 0.00 -50 0.243 Q14500 I249V Polymorphism 0.085 0.176 1.00 -37 0.072 Q14500 Q192H Polymorphism 0.513 0.581 0.01 -12 0.545 Q14507 G62C Polymorphism 0.566 0.074 NA 11 0.072 Q14511 T577M Polymorphism NA 0.188 0.02 31 0.348 Q14515 H106D Polymorphism 0.717 0.034 0.81 9 0.040 Q14517 A131V Polymorphism NA 0.354 0.10 31 0.368 Q14517 A1564T Polymorphism NA 0.443 0.65 -20 0.183 Q14524 G9V Disease NA 0.882 0.03 43 0.826 Q14524 R27H Disease NA 0.657 0.13 33 0.502 Q14524 R43Q Disease NA 0.170 0.44 18 0.253 Q14524 V95I Disease NA 0.540 0.00 25 0.512 Q14524 A226V Disease 0.786 0.689 0.07 2 0.604 Q14524 A572D Disease 0.400 0.217 0.34 31 0.362 Q14524 A735E Disease 0.853 0.801 0.01 50 0.947 Q14524 A735V Disease 0.771 0.760 0.01 28 0.840 Q14524 A997S Disease 0.113 0.268 0.74 -36 0.209 Q14524 C896S Disease 0.851 0.873 0.02 61 0.808 Q14524 D356N Disease 0.839 0.849 0.00 53 0.802 Q14524 E161K Disease NA 0.324 0.02 59 0.630 Q14524 F532C Disease 0.868 0.643 0.09 60 0.898 Q14524 F851L Disease 0.348 0.853 0.11 35 0.483 Q14524 F892I Disease 0.508 0.924 0.01 62 0.920 Q14524 G298S Disease 0.435 0.413 0.75 2 0.310 Q14524 G319S Disease 0.585 0.473 0.03 33 0.574 Q14524 G351V Disease 0.603 0.877 0.00 34 0.683 Q14524 G514C Disease 0.743 0.392 0.14 29 0.625 Q14524 G552R Polymorphism 0.125 0.270 0.14 27 0.287 Q14524 G615E Disease 0.538 0.320 0.88 1 0.522 Q14524 G639R Disease 0.113 0.128 0.59 13 0.105 Q14524 G752R Disease 0.951 0.649 0.01 57 0.952 Q14524 H558R Polymorphism 0.078 0.085 1.00 -5 0.058 Q14524 H681P Disease 0.300 0.319 0.13 34 0.384 Q14524 I230V Disease 0.134 0.724 0.33 -1 0.257 Q14524 K126E Disease NA 0.436 0.09 50 0.609 Q14524 L212P Disease 0.926 0.857 0.00 63 0.932 Q14524 L325R Disease 0.879 0.690 0.00 66 0.916 Q14524 L567Q Disease 0.629 0.188 0.62 -36 0.399 Q14524 L619F Disease 0.378 0.220 0.43 19 0.346 Q14524 M369K Disease 0.887 0.605 0.00 60 0.890 Q14524 N406K Disease 0.813 0.891 0.01 37 0.857 Q14524 N406S Disease 0.774 0.849 0.10 34 0.616 Q14524 P336L Disease 0.732 0.813 0.00 9 0.761 Q14524 R225Q Disease 0.866 0.954 0.00 53 0.952 Q14524 R225W Disease 0.977 0.973 0.00 52 0.975 Q14524 R282H Disease 0.570 0.223 0.07 35 0.527 Q14524 R367C Disease 0.962 0.400 0.00 53 0.753 Q14524 R367H Disease 0.910 0.388 0.01 48 0.667 Q14524 R680H Disease 0.088 0.208 0.17 -7 0.182 Q14524 R814Q Disease 0.800 0.806 0.00 53 0.951 Q14524 R878C Disease 0.940 0.906 0.00 68 0.950 Q14524 R965C Disease 0.855 0.949 0.00 58 0.944 Q14524 S910L Disease 0.444 0.500 0.10 7 0.589 Q14524 S941N Disease 0.547 0.633 0.22 5 0.328 Q14524 T187I Disease NA 0.514 0.01 43 0.801 Q14524 T220I Disease 0.816 0.667 0.00 10 0.699 Q14524 T353I Disease 0.892 0.691 0.10 48 0.822 Q14524 T512I Disease 0.388 0.127 0.19 4 0.244 Q14524 V294M Disease 0.415 0.087 0.22 26 0.155 Q14524 A1180V Polymorphism 0.123 0.111 0.25 35 0.162 Q14524 A1330P Disease NA 0.881 0.01 62 0.896 Q14524 A1330T Disease NA 0.762 0.11 16 0.434 Q14524 A1569P Disease 0.445 0.654 0.03 27 0.773 Q14524 A1649V Disease 0.775 0.749 0.01 38 0.716 Q14524 A1924T Disease 0.315 0.559 0.98 -6 0.389 Q14524 C1850S Disease 0.890 0.721 0.01 24 0.864 Q14524 D1041N Polymorphism NA 0.242 0.50 12 0.319 Q14524 D1114N Disease NA 0.365 0.55 11 0.303 Q14524 D1275N Disease 0.838 0.861 0.00 54 0.969 Q14524 D1595N Disease 0.844 0.817 0.00 56 0.955 Q14524 D1714G Disease 0.837 0.526 0.02 39 0.808 Q14524 D1790G Disease 0.869 0.701 0.00 47 0.882 Q14524 D1819N Disease 0.492 0.438 0.67 -17 0.398 Q14524 D1839G Disease 0.837 0.548 0.02 57 0.911 Q14524 E1053K Disease NA 0.655 0.12 31 0.516 Q14524 E1225K Disease 0.854 0.892 0.00 58 0.941 Q14524 E1240Q Disease 0.759 0.279 0.23 -7 0.562 Q14524 E1295K Disease 0.324 0.522 0.18 28 0.301 Q14524 E1784K Disease 0.468 0.399 0.22 20 0.375 Q14524 F1250L Disease 0.758 0.859 0.00 47 0.895 Q14524 F1293S Disease 0.518 0.733 0.14 -13 0.122 Q14524 F1344S Disease 0.875 0.911 0.00 24 0.808 Q14524 F1473C Disease 0.999 0.899 0.00 61 0.969 Q14524 F1486L Disease 0.756 0.725 0.00 38 0.691 Q14524 F1705S Disease 0.921 0.947 0.00 32 0.901 Q14524 F2004L Disease 0.102 0.076 NA -25 0.066 Q14524 G1084S Disease NA 0.074 0.80 -7 0.103 Q14524 G1262S Disease 0.888 0.857 0.00 36 0.898 Q14524 G1319V Disease 0.917 0.603 0.01 44 0.856 Q14524 G1406R Disease 0.630 0.705 0.00 57 0.921 Q14524 G1408R Disease 0.903 0.679 0.04 63 0.947 Q14524 G1502S Disease 0.833 0.530 0.04 -17 0.650 Q14524 G1740R Disease 0.907 0.878 0.01 41 0.844 Q14524 G1743E Disease 0.877 0.926 0.02 62 0.847 Q14524 G1743R Disease 0.907 0.912 0.01 65 0.899 Q14524 G1935S Disease 0.054 0.417 0.43 -22 0.211 Q14524 I1660V Disease 0.499 0.763 0.00 -13 0.412 Q14524 I1768V Disease 0.401 0.176 0.00 -22 0.288 Q14524 I1968S Disease 0.468 0.140 0.70 -7 0.104 Q14524 K1236N Disease 0.542 0.531 0.01 -17 0.267 Q14524 K1527R Disease 0.223 0.642 0.69 -12 0.163 Q14524 L1501V Disease 0.627 0.579 0.01 26 0.504 Q14524 L1825P Disease 0.951 0.961 0.00 44 0.912 Q14524 M1652R Disease 0.867 0.820 0.00 58 0.826 Q14524 M1766L Disease 0.601 0.466 0.00 12 0.570 Q14524 N1325S Disease 0.316 0.546 0.07 25 0.361 Q14524 P1298L Disease 0.566 0.555 0.19 -10 0.596 Q14524 P1332L Disease 0.916 0.713 0.16 29 0.869 Q14524 P1438L Disease 0.947 0.786 0.00 44 0.869 Q14524 P2006A Disease 0.404 0.053 NA 0 0.049 Q14524 R1023H Disease NA 0.081 0.24 -13 0.120 Q14524 R1193Q Disease NA 0.480 0.42 44 0.400 Q14524 R1232W Disease 0.825 0.481 0.00 53 0.806 Q14524 R1432G Disease 0.495 0.112 0.24 28 0.261 Q14524 R1512W Disease 0.976 0.815 0.00 57 0.925 Q14524 R1623L Disease 0.862 0.924 0.00 37 0.882 Q14524 R1623Q Disease 0.804 0.919 0.09 42 0.628 Q14524 R1626P Disease 0.902 0.968 0.01 67 0.954 Q14524 R1644C Disease 0.953 0.963 0.00 49 0.944 Q14524 R1644H Disease 0.890 0.958 0.09 24 0.839 Q14524 R1826H Disease 0.691 0.605 0.22 18 0.770 Q14524 S1333Y Disease 0.890 0.670 0.00 34 0.840 Q14524 S1382I Disease 0.659 0.492 0.10 30 0.653 Q14524 S1609W Disease 0.899 0.702 0.00 11 0.816 Q14524 S1710L Disease 0.849 0.779 0.02 37 0.784 Q14524 S1787N Disease 0.547 0.238 0.10 27 0.564 Q14524 S1904L Disease 0.594 0.565 0.06 20 0.755 Q14524 T1304M Disease NA 0.678 0.00 18 0.720 Q14524 T1620K Disease 0.839 0.803 0.00 66 0.886 Q14524 T1620M Disease 0.914 0.787 0.00 42 0.868 Q14524 T1645M Disease 0.914 0.862 0.00 35 0.847 Q14524 V1405L Disease 0.658 0.723 0.01 -4 0.741 Q14524 V1763M Disease 0.810 0.150 0.00 -15 0.355 Q14524 V1777M Disease 0.773 0.457 0.05 -8 0.673 Q14524 V1951L Disease 0.098 0.108 0.24 1 0.081 Q14524 Y1494N Disease 0.892 0.809 0.01 49 0.889 Q14524 Y1795C Disease 0.846 0.697 0.00 33 0.824 Q14524 Y1795H Disease 0.620 0.477 0.00 51 0.773 Q14527 E362Q Polymorphism NA 0.072 0.00 24 0.166 Q14527 N311S Polymorphism 0.194 0.325 0.67 43 0.228 Q14532 Q72R Polymorphism 0.342 0.076 0.34 -11 0.123 Q14532 I171T Polymorphism 0.789 0.542 0.00 21 0.665 Q14532 S222Y Polymorphism 0.910 0.777 0.00 23 0.851 Q14533 G52R Polymorphism 0.377 0.571 0.11 42 0.565 Q14533 E402K Disease 0.876 0.941 0.00 51 0.887 Q14533 E413K Disease 0.895 0.800 0.00 48 0.855 Q14542 P94L Polymorphism 0.482 0.426 0.31 30 0.470 Q14562 A1069G Polymorphism 0.611 0.104 0.33 -1 0.259 Q14565 M200V Polymorphism 0.195 0.659 0.24 -12 0.314 Q14566 E806K Polymorphism 0.123 0.211 0.42 20 0.270 Q14568 T235A Polymorphism NA 0.187 1.00 -21 0.186 Q14571 A453V Polymorphism 0.348 0.229 0.06 0 0.357 Q14573 L374W Polymorphism 0.895 0.620 0.00 51 0.901 Q14573 R667Q Polymorphism 0.181 0.095 1.00 -7 0.094 Q14573 E2398Q Polymorphism 0.531 0.723 0.03 27 0.588 Q14573 G1029V Polymorphism 0.086 0.266 0.12 -18 0.248 Q14573 L1552V Polymorphism 0.350 0.110 0.05 4 0.229 Q14573 L2436V Polymorphism 0.142 0.088 1.00 -28 0.107 Q14573 R1850Q Polymorphism 0.187 0.257 0.32 -10 0.225 Q14574 A28D Polymorphism 0.030 0.362 0.03 -2 0.337 Q14574 S78T Polymorphism NA 0.150 0.74 -40 0.123 Q14574 K180Q Polymorphism 0.208 0.469 1.00 -10 0.162 Q14574 N239S Polymorphism 0.687 0.804 0.00 44 0.757 Q14574 R102K Polymorphism NA 0.238 0.58 -53 0.228 Q14574 R199W Polymorphism 0.876 0.337 0.01 43 0.661 Q14588 V208M Polymorphism 0.360 0.222 0.02 20 0.457 Q14593 G454E Polymorphism 0.835 0.510 0.06 27 0.778 Q14623 E95K Disease 0.786 0.919 0.00 35 0.868 Q14623 P46L Disease 0.597 0.768 0.00 42 0.832 Q14623 D100E Disease 0.674 0.704 0.00 59 0.897 Q14623 D100N Disease 0.776 0.775 0.00 61 0.867 Q14623 E131K Disease 0.792 0.955 0.00 28 0.834 Q14623 V190A Disease 0.699 0.739 0.00 43 0.850 Q14624 I86N Polymorphism NA 0.955 0.01 53 0.913 Q14624 L791P Polymorphism 0.088 0.316 0.29 -26 0.063 Q14624 M714I Polymorphism 0.112 0.131 0.47 8 0.091 Q14624 Q669L Polymorphism NA 0.097 0.82 -64 0.061 Q14627 W111R Polymorphism NA 0.172 0.16 55 0.130 Q14642 K45R Polymorphism 0.176 0.132 0.33 -2 0.133 Q14643 M769V Polymorphism 0.254 0.770 0.36 45 0.475 Q14653 R96Q Polymorphism 0.205 0.437 0.34 23 0.343 Q14653 E377K Polymorphism 0.232 0.737 0.08 40 0.525 Q14653 S427T Polymorphism NA 0.062 NA -37 0.020 Q14654 A18G Polymorphism 0.160 0.220 0.19 8 0.193 Q14654 C42R Disease 0.987 0.943 0.00 46 0.942 Q14654 E10K Polymorphism 0.178 0.386 0.00 22 0.229 Q14654 E23K Polymorphism 0.090 0.253 1.00 1 0.040 Q14654 F35L Disease 0.336 0.487 0.48 -25 0.363 Q14654 F35V Disease 0.498 0.522 0.30 -15 0.414 Q14654 F55L Disease 0.336 0.767 0.01 37 0.670 Q14654 G40D Disease 0.966 0.881 0.00 67 0.948 Q14654 G53D Disease 0.683 0.697 0.30 45 0.675 Q14654 G53R Disease 0.751 0.762 0.34 45 0.670 Q14654 G53S Disease 0.559 0.270 0.50 19 0.553 Q14654 H46Y Disease 0.551 0.738 1.00 12 0.629 Q14654 K67N Disease 0.529 0.686 0.00 0 0.562 Q14654 Q52R Disease 0.413 0.485 0.76 17 0.338 Q14654 R34H Disease 0.992 0.909 0.00 67 0.967 Q14654 R50P Disease 0.717 0.812 0.27 31 0.672 Q14654 R50Q Disease 0.514 0.478 0.56 -11 0.462 Q14654 V59G Disease 0.690 0.703 0.00 5 0.734 Q14654 V59M Disease 0.430 0.401 0.10 -29 0.181 Q14654 W91R Disease 0.976 0.957 0.00 48 0.933 Q14654 A101D Disease 0.086 0.746 0.57 -45 0.115 Q14654 C166Y Disease 0.825 0.783 0.00 -2 0.794 Q14654 E322K Disease 0.473 0.928 0.47 4 0.478 Q14654 F333I Disease 0.514 0.897 0.00 49 0.820 Q14654 G134A Disease 0.985 0.844 0.00 66 0.956 Q14654 H259R Disease 0.990 0.953 0.00 62 0.963 Q14654 I148S Polymorphism 0.168 0.681 0.01 0 0.615 Q14654 I182V Disease 0.201 0.228 1.00 -29 0.163 Q14654 I296L Disease 0.238 0.664 0.29 -18 0.367 Q14654 I337V Polymorphism 0.108 0.127 0.69 -44 0.100 Q14654 K170N Disease 0.987 0.947 0.00 38 0.943 Q14654 K170R Disease 0.958 0.913 0.00 0 0.803 Q14654 K170T Disease 0.988 0.942 0.00 42 0.938 Q14654 L147P Disease 0.417 0.808 0.06 23 0.790 Q14654 L164P Disease 0.811 0.830 0.02 36 0.861 Q14654 P254L Disease 0.993 0.954 0.00 52 0.956 Q14654 P266L Disease 0.974 0.934 0.00 45 0.934 Q14654 R136L Disease 0.978 0.954 0.01 56 0.957 Q14654 R195H Polymorphism 0.455 0.500 0.00 -1 0.504 Q14654 R201C Disease 0.991 0.944 0.00 68 0.957 Q14654 R201H Disease 0.981 0.843 0.00 68 0.949 Q14654 R201L Disease 0.977 0.907 0.00 61 0.954 Q14654 R301H Disease 0.961 0.813 0.00 69 0.943 Q14654 S116P Disease 0.647 0.926 0.02 63 0.930 Q14654 Y330C Disease 0.980 0.893 0.11 30 0.927 Q14654 Y330S Disease 0.952 0.858 0.00 33 0.907 Q14656 S70L Polymorphism NA 0.142 NA -7 0.095 Q14656 R138Q Polymorphism NA 0.094 NA -9 0.068 Q14674 S614R Polymorphism 0.193 0.166 NA 23 0.155 Q14674 I1136V Polymorphism 0.258 0.029 NA 4 0.073 Q14674 K1435M Polymorphism 0.535 0.142 NA 24 0.188 Q14676 R268K Polymorphism 0.147 0.054 1.00 -36 0.034 Q14676 E1509D Polymorphism 0.176 0.120 0.19 32 0.120 Q14676 P1100A Polymorphism 0.329 0.093 0.06 31 0.077 Q14676 R1883Q Polymorphism NA 0.149 0.01 46 0.171 Q14676 S1112F Polymorphism 0.609 0.174 0.01 48 0.205 Q14678 A664V Polymorphism 0.325 0.191 NA -18 0.200 Q14678 E432Q Polymorphism NA 0.254 0.00 37 0.267 Q14678 K321R Polymorphism NA 0.149 0.02 20 0.156 Q14678 N901S Polymorphism 0.296 0.158 0.00 7 0.098 Q14678 S464A Polymorphism NA 0.055 0.01 -44 0.014 Q14678 I1055T Polymorphism NA 0.110 0.25 -3 0.080 Q14679 E34Q Polymorphism NA 0.146 NA -16 0.195 Q14679 N17S Polymorphism NA 0.178 NA 28 0.038 Q14679 G518S Polymorphism NA 0.252 NA 12 0.199 Q14679 T1138I Polymorphism NA 0.150 NA 5 0.147 Q14680 K219R Polymorphism 0.076 0.231 0.05 -39 0.198 Q14680 R333K Polymorphism 0.085 0.293 0.13 -20 0.209 Q14683 E493A Disease 0.647 0.361 0.07 14 0.608 Q14686 P512L Polymorphism NA 0.118 0.05 40 0.136 Q14686 I1995V Polymorphism 0.136 0.087 0.30 -44 0.069 Q14690 A623S Polymorphism 0.345 0.259 0.61 2 0.342 Q14690 A780S Polymorphism 0.276 0.198 0.80 17 0.067 Q14690 S397N Polymorphism 0.419 0.891 0.35 25 0.690 Q14690 D1871A Polymorphism NA 0.178 0.00 17 0.251 Q14690 L1216F Polymorphism 0.355 0.101 0.08 -38 0.139 Q14690 P1453S Polymorphism 0.296 0.087 0.25 -53 0.076 Q14691 V97I Polymorphism 0.115 0.271 0.52 -20 0.206 Q14692 M884V Polymorphism 0.167 0.371 0.62 7 0.286 Q14692 R237H Polymorphism 0.808 0.964 0.00 61 0.906 Q14692 S552P Polymorphism 0.370 0.063 NA -49 0.034 Q14693 P610S Polymorphism 0.462 0.351 0.80 -24 0.261 Q14694 V204L Polymorphism NA 0.070 NA -10 0.055 Q14695 S85N Polymorphism NA 0.248 NA 17 0.083 Q14697 R173Q Polymorphism NA 0.415 0.56 21 0.313 Q14697 R309C Polymorphism 0.691 0.818 0.03 43 0.813 Q14703 I6T Polymorphism NA 0.222 0.52 5 0.115 Q14703 R90G Polymorphism 0.643 0.397 0.00 47 0.645 Q14714 S186N Polymorphism NA 0.237 NA 11 0.178 Q14739 P119L Disease NA 0.308 0.00 25 0.469 Q14739 P569R Disease 0.816 0.950 0.00 50 0.930 Q14739 R169C Polymorphism NA 0.500 0.00 42 0.723 Q14739 S154N Polymorphism NA 0.061 0.59 10 0.068 Q14746 N304K Polymorphism 0.112 0.243 0.00 -4 0.185 Q14746 V589I Polymorphism 0.134 0.102 0.37 -34 0.101 Q14749 L50P Disease 0.730 0.786 0.19 29 0.841 Q14749 H177N Disease 0.628 0.880 0.76 47 0.853 Q14749 N141S Disease 0.457 0.771 0.33 33 0.641 Q14764 R651Q Polymorphism 0.277 0.485 0.08 21 0.449 Q14764 V635I Polymorphism 0.081 0.077 0.97 -41 0.071 Q14767 P319Q Polymorphism NA 0.090 0.11 34 0.099 Q14773 V208L Polymorphism 0.084 0.145 0.88 -18 0.056 Q14774 S116P Polymorphism 0.082 0.190 0.01 41 0.163 Q14789 T911S Polymorphism NA 0.039 0.85 -15 0.056 Q14789 C1713F Polymorphism NA 0.060 0.76 46 0.095 Q14789 P1249S Polymorphism NA 0.056 0.54 13 0.041 Q14790 D285H Polymorphism 0.279 0.447 0.30 23 0.236 Q14790 R248W Disease NA 0.354 0.02 43 0.572 Q14790 S219T Polymorphism 0.195 0.159 0.36 -67 0.156 Q147U1 C450Y Polymorphism 0.961 0.432 1.00 18 0.088 Q147U7 H20Y Polymorphism NA 0.087 NA 6 0.081 Q147U7 R64W Polymorphism NA 0.095 NA 29 0.076 Q14831 G745E Polymorphism NA 0.639 0.01 22 0.771 Q14831 Y433F Polymorphism 0.415 0.409 0.69 26 0.212 Q14832 G475D Polymorphism 0.178 0.772 0.72 13 0.264 Q14833 L169F Polymorphism NA 0.929 0.00 9 0.594 Q14833 V797I Polymorphism 0.101 0.335 1.00 -34 0.229 Q14849 G216A Polymorphism NA 0.225 0.10 0 0.242 Q14849 R117Q Polymorphism NA 0.275 0.00 11 0.261 Q14896 G5R Disease NA 0.112 0.30 14 0.114 Q14896 T59A Disease NA 0.095 0.95 -10 0.074 Q14896 A416S Disease NA 0.241 0.73 4 0.182 Q14896 A521T Polymorphism NA 0.216 0.32 -14 0.234 Q14896 A832T Disease 0.244 0.334 0.30 44 0.239 Q14896 A832V Disease 0.347 0.321 0.39 41 0.204 Q14896 C565R Disease NA 0.247 0.01 75 0.467 Q14896 D228N Disease NA 0.257 0.27 37 0.321 Q14896 D603V Disease NA 0.243 0.19 56 0.265 Q14896 D604N Disease NA 0.238 0.77 35 0.279 Q14896 D769N Disease 0.458 0.264 0.10 57 0.380 Q14896 E258K Disease NA 0.703 0.21 48 0.624 Q14896 E450Q Disease NA 0.252 0.14 48 0.363 Q14896 E541Q Disease NA 0.249 0.27 42 0.424 Q14896 E758D Disease NA 0.272 0.05 0 0.289 Q14896 G263R Disease NA 0.210 0.09 45 0.337 Q14896 G278E Disease NA 0.329 0.25 55 0.316 Q14896 G279A Disease NA 0.245 0.86 -23 0.223 Q14896 G415S Polymorphism NA 0.268 0.33 57 0.392 Q14896 G489R Disease NA 0.218 0.00 59 0.386 Q14896 G506R Disease NA 0.239 0.01 61 0.359 Q14896 G522W Disease NA 0.255 0.01 58 0.464 Q14896 H257P Disease NA 0.355 0.22 53 0.599 Q14896 K810R Disease 0.486 0.323 0.16 54 0.346 Q14896 L352P Disease NA 0.736 0.11 47 0.837 Q14896 L544M Polymorphism NA 0.256 0.15 55 0.377 Q14896 L668H Disease NA 0.249 0.00 51 0.458 Q14896 N754K Disease NA 0.292 0.19 37 0.458 Q14896 N947T Disease 0.718 0.342 0.03 53 0.583 Q14896 P161S Disease NA 0.309 0.12 51 0.453 Q14896 P607L Disease NA 0.235 0.43 23 0.285 Q14896 P872H Disease 0.959 0.309 0.01 61 0.767 Q14896 Q997E Disease 0.411 0.253 0.00 19 0.216 Q14896 Q997R Disease 0.419 0.256 0.00 47 0.257 Q14896 R273H Disease NA 0.248 0.05 46 0.367 Q14896 R282W Disease NA 0.269 0.08 58 0.307 Q14896 R457H Disease NA 0.229 0.25 5 0.343 Q14896 R494G Disease NA 0.230 0.10 55 0.363 Q14896 R494Q Disease NA 0.188 0.28 61 0.372 Q14896 R501Q Disease NA 0.253 0.04 45 0.317 Q14896 R501W Disease NA 0.262 0.00 55 0.456 Q14896 R653H Disease NA 0.271 0.11 36 0.369 Q14896 R667H Disease NA 0.228 0.02 56 0.357 Q14896 R667P Disease NA 0.249 0.02 58 0.464 Q14896 R732C Disease NA 0.246 0.20 24 0.338 Q14896 R809H Disease 0.830 0.307 0.01 55 0.684 Q14896 R819Q Disease 0.429 0.309 0.13 60 0.352 Q14896 R833T Disease 0.089 0.320 0.62 21 0.039 Q14896 R833W Disease 0.728 0.301 0.02 44 0.435 Q14896 V158M Polymorphism NA 0.235 0.09 56 0.443 Q14896 V189I Polymorphism NA 0.394 0.47 16 0.314 Q14896 V219L Disease NA 0.191 0.30 43 0.239 Q14896 V256I Disease NA 0.304 0.15 47 0.334 Q14896 V895M Polymorphism 0.351 0.318 0.06 -1 0.457 Q14896 W791R Disease 0.880 0.339 0.00 68 0.849 Q14896 Y237S Disease NA 0.798 0.00 63 0.892 Q14896 A1193T Disease 0.481 0.418 0.49 13 0.324 Q14896 A1254T Disease 0.729 0.793 0.00 38 0.856 Q14896 F1112I Disease 0.685 0.276 0.02 48 0.509 Q14896 G1247R Disease 0.696 0.653 0.03 55 0.717 Q14896 I1130T Disease 0.483 0.275 0.05 20 0.066 Q14896 P1002Q Disease 0.995 0.277 0.00 39 0.694 Q14896 R1001Q Disease 0.703 0.248 0.17 41 0.480 Q14896 T1027S Disease 0.151 0.293 0.74 -1 0.218 Q14896 V1114I Disease NA 0.282 0.09 35 0.315 Q14929 E78K Polymorphism 0.305 0.557 0.57 -4 0.394 Q14929 P72L Polymorphism 0.540 0.725 0.44 3 0.482 Q14929 Q596H Polymorphism NA 0.340 0.00 0 0.451 Q14929 R381C Polymorphism 0.752 0.328 0.00 51 0.732 Q14929 S152L Polymorphism NA 0.123 0.32 -6 0.210 Q14934 S246N Polymorphism 0.413 0.073 0.44 14 0.076 Q14934 S800P Polymorphism 0.073 0.191 0.33 27 0.049 Q14943 S2L Polymorphism NA 0.435 1.00 -82 0.421 Q14943 G259R Polymorphism 0.647 0.459 0.07 27 0.580 Q14943 P203S Polymorphism 0.789 0.150 0.43 -5 0.251 Q14954 R91K Polymorphism 0.319 0.168 0.03 -8 0.231 Q14954 L111V Polymorphism 0.529 0.151 0.06 -9 0.306 Q14956 N197H Polymorphism 0.526 0.471 0.15 44 0.663 Q14956 S294F Polymorphism 0.687 0.853 0.01 43 0.860 Q14956 S538R Polymorphism 0.316 0.204 0.50 23 0.225 Q14966 I110V Polymorphism 0.093 0.193 NA 16 0.193 Q14966 N980S Polymorphism NA 0.028 0.27 15 0.045 Q14966 A1912V Polymorphism 0.105 0.051 0.05 13 0.044 Q14966 V1726M Polymorphism 0.080 0.019 NA -37 0.024 Q14978 S456P Polymorphism 0.371 0.138 0.03 27 0.061 Q14980 A794G Polymorphism 0.289 0.164 0.38 15 0.098 Q14980 K242R Polymorphism 0.336 0.118 0.23 17 0.096 Q14980 Y1836H Polymorphism 0.690 0.212 NA 18 0.198 Q14982 P95R Disease 0.167 0.620 0.56 11 0.126 Q14990 F243L Polymorphism 0.226 0.412 0.00 30 0.391 Q14990 S216N Polymorphism 0.068 0.093 0.82 -10 0.044 Q14993 E496G Polymorphism NA 0.171 NA 18 0.315 Q14994 V133G Polymorphism NA 0.362 0.38 16 0.411 Q14995 P21H Polymorphism NA 0.271 0.15 24 0.400 Q14995 L386M Polymorphism NA 0.257 0.43 -39 0.227 Q14995 Q282K Polymorphism NA 0.179 0.73 29 0.190 Q14997 I872V Polymorphism NA 0.079 0.44 15 0.100 Q14999 Q813R Polymorphism NA 0.072 0.87 -11 0.086 Q14999 R852Q Polymorphism NA 0.210 0.05 25 0.284 Q14999 H1464P Disease NA 0.717 0.01 45 0.773 Q14999 L1014R Disease 0.727 0.806 0.00 58 0.919 Q14999 Q1246G Disease 0.560 0.397 0.00 33 0.641 Q149M9 L211F Polymorphism NA 0.209 0.18 26 0.277 Q14C87 D460H Polymorphism 0.552 0.472 0.16 32 0.595 Q14C87 E436Q Polymorphism 0.836 0.911 0.00 37 0.880 Q14CN2 P43S Polymorphism NA 0.345 0.00 -25 0.285 Q14CN2 D443V Polymorphism 0.344 0.479 0.08 14 0.431 Q14CN2 V810L Polymorphism 0.258 0.757 0.00 51 0.530 Q14CN4 D366E Polymorphism 0.279 0.294 0.31 -28 0.231 Q14CN4 N171D Polymorphism 0.545 0.312 0.09 11 0.598 Q14CN4 Y264C Polymorphism 0.933 0.809 0.00 36 0.856 Q14CX7 L426F Polymorphism 0.406 0.105 0.11 6 0.123 Q14CX7 L915I Polymorphism 0.123 0.126 0.00 -58 0.058 Q14CZ0 N221S Polymorphism NA 0.059 0.54 3 0.064 Q14CZ7 L3F Polymorphism NA 0.029 0.96 -40 0.023 Q14CZ7 E459G Polymorphism 0.814 0.310 0.05 38 0.541 Q14CZ8 M218V Polymorphism 0.136 0.079 1.00 8 0.029 Q14D04 L329V Polymorphism 0.261 0.159 0.47 -3 0.124 Q14D04 S208C Polymorphism 0.549 0.098 0.10 -10 0.107 Q14D04 S271C Polymorphism 0.592 0.113 0.05 -2 0.151 Q14DG7 A658V Polymorphism 0.277 0.259 1.00 8 0.295 Q15003 V539A Polymorphism NA 0.062 0.24 -33 0.075 Q15020 D23E Polymorphism NA 0.097 0.65 -40 0.029 Q15020 V591M Disease 0.534 0.056 0.12 -19 0.140 Q15021 K580R Polymorphism 0.423 0.032 0.22 8 0.094 Q15021 V797M Polymorphism 0.331 0.122 0.03 10 0.262 Q15021 T1321S Polymorphism 0.241 0.098 NA -34 0.088 Q15024 R169Q Polymorphism 0.208 0.297 0.30 -26 0.183 Q15025 A146V Polymorphism NA 0.053 0.00 3 0.088 Q15025 A260V Polymorphism NA 0.179 0.18 -31 0.155 Q15025 P103S Polymorphism NA 0.116 0.29 -1 0.090 Q15025 P151A Polymorphism NA 0.379 0.13 32 0.283 Q15027 R68C Polymorphism NA 0.484 0.05 29 0.450 Q15027 R533W Polymorphism 0.591 0.583 0.03 55 0.836 Q15031 E831D Polymorphism 0.420 0.136 0.51 -29 0.138 Q15032 Q632P Polymorphism 0.457 0.441 0.33 28 0.321 Q15034 E946Q Polymorphism 0.209 0.288 0.39 -17 0.274 Q15040 S48R Polymorphism 0.186 0.170 0.53 6 0.065 Q15046 G179A Polymorphism NA 0.899 0.00 48 0.854 Q15046 T595S Polymorphism NA 0.079 0.81 6 0.048 Q15047 A824P Polymorphism 0.193 0.621 1.00 41 0.340 Q15047 N236S Polymorphism 0.136 0.129 0.04 6 0.128 Q15047 P506S Polymorphism NA 0.179 0.04 22 0.146 Q15048 G437D Polymorphism 0.364 0.131 0.99 38 0.112 Q15049 G59E Disease NA 0.798 NA 70 0.875 Q15049 P92S Disease NA 0.568 NA 14 0.665 Q15049 S93L Disease NA 0.313 NA 27 0.169 Q15049 C171F Polymorphism NA 0.260 NA 49 0.160 Q15049 G212R Disease NA 0.891 NA 63 0.909 Q15049 N141K Disease NA 0.484 NA 72 0.627 Q15049 N141S Disease NA 0.307 NA 50 0.299 Q15049 S280L Disease NA 0.706 NA 48 0.798 Q15049 T118R Disease NA 0.832 NA 59 0.867 Q15051 I393N Polymorphism 0.427 0.325 0.31 17 0.444 Q15051 R435C Polymorphism 0.803 0.265 0.00 47 0.472 Q15052 Q297H Polymorphism 0.727 0.490 0.06 24 0.595 Q15053 Q26K Polymorphism NA 0.074 NA 24 0.048 Q15059 A172V Polymorphism 0.132 0.110 0.61 14 0.115 Q15059 K435Q Polymorphism 0.210 0.109 0.57 -1 0.208 Q15059 R441H Polymorphism 0.257 0.159 0.24 -2 0.255 Q15063 V814M Polymorphism 0.131 0.206 NA 42 0.114 Q15067 G101S Polymorphism 0.402 0.781 0.90 14 0.576 Q15067 G178C Disease 0.929 0.939 0.00 60 0.944 Q15067 M278V Disease 0.830 0.899 0.02 61 0.849 Q15067 T153I Polymorphism 0.746 0.731 0.08 41 0.803 Q15070 V91I Polymorphism NA 0.101 0.37 11 0.157 Q15072 R8K Polymorphism 0.477 0.287 0.18 22 0.388 Q15109 G82S Polymorphism 0.592 0.362 0.61 52 0.414 Q15109 Q100R Polymorphism 0.111 0.082 0.77 0 0.079 Q15111 P454S Polymorphism 0.943 0.847 0.01 2 0.908 Q15111 S937N Polymorphism 0.251 0.135 0.22 23 0.134 Q15111 V667I Polymorphism 0.622 0.652 0.05 24 0.559 Q15116 A215V Polymorphism NA 0.183 NA -6 0.050 Q15118 A134T Polymorphism 0.164 0.132 0.61 -40 0.111 Q15118 N412T Polymorphism 0.131 0.126 0.46 -21 0.100 Q15125 E80K Disease 0.747 0.983 0.00 74 0.903 Q15125 R110Q Disease 0.900 0.969 0.00 66 0.954 Q15125 R147G Disease 0.696 0.819 0.11 49 0.821 Q15125 R147H Disease 0.774 0.833 0.05 51 0.898 Q15126 V125M Polymorphism 0.262 0.150 0.15 9 0.119 Q15131 P96L Polymorphism 0.364 0.434 0.06 17 0.456 Q15131 C358Y Polymorphism NA 0.182 1.00 -13 0.176 Q15131 N168S Polymorphism 0.999 0.911 0.00 56 0.896 Q15131 R342H Polymorphism NA 0.396 0.46 7 0.411 Q15139 H891R Polymorphism 0.054 0.049 0.63 28 0.036 Q15139 K478Q Polymorphism 0.086 0.062 1.00 -3 0.053 Q15139 P679L Polymorphism 0.337 0.272 0.03 7 0.383 Q15139 R825K Polymorphism 0.195 0.136 0.51 -4 0.117 Q15149 A2194V Polymorphism NA 0.111 0.41 -23 0.174 Q15149 A3171V Polymorphism 0.326 0.225 0.06 26 0.351 Q15149 L1321V Polymorphism 0.271 0.491 0.03 26 0.631 Q15149 R2110W Disease NA 0.488 0.04 38 0.629 Q15149 R2150W Polymorphism NA 0.540 0.01 33 0.530 Q15149 S2791P Polymorphism 0.058 0.652 0.29 1 0.136 Q15149 T3486M Polymorphism NA 0.141 0.11 16 0.249 Q15149 V3162I Polymorphism 0.148 0.150 0.36 -8 0.200 Q15154 S159N Polymorphism 0.325 0.135 0.42 -2 0.097 Q15155 K458N Polymorphism 0.306 0.177 0.10 11 0.276 Q15155 M493V Polymorphism 0.757 0.033 1.00 -20 0.007 Q15155 M580V Polymorphism 0.365 0.027 1.00 -13 0.007 Q15155 R1195G Polymorphism 0.166 0.255 0.79 16 0.136 Q15165 C311S Polymorphism 0.640 0.101 1.00 -10 0.059 Q15165 V172L Polymorphism 0.287 0.606 0.44 0 0.390 Q15198 H23Y Disease 0.373 0.070 0.00 35 0.130 Q15208 D145N Polymorphism 0.660 0.327 0.36 -9 0.583 Q15256 K314R Polymorphism NA 0.045 1.00 16 0.053 Q15256 V386I Polymorphism 0.101 0.054 0.20 -36 0.078 Q15256 V439I Polymorphism NA 0.043 0.85 -17 0.060 Q15257 S357L Polymorphism 0.534 0.160 0.01 0 0.268 Q15269 D25N Polymorphism 0.200 0.835 0.15 39 0.506 Q15269 F551I Polymorphism 0.617 0.522 0.04 46 0.568 Q15293 D73Y Polymorphism 0.745 0.578 0.00 -5 0.767 Q15293 Q74E Polymorphism 0.198 0.165 0.65 -24 0.128 Q15293 R188P Polymorphism 0.769 0.794 0.12 56 0.896 Q15319 L223P Disease 0.916 0.920 0.00 44 0.910 Q15319 L289F Disease 0.990 0.921 0.00 36 0.946 Q15323 A82V Polymorphism 0.748 0.348 0.02 -12 0.642 Q15323 A377V Polymorphism 0.209 0.156 0.52 13 0.154 Q15327 T116M Disease 0.683 0.095 0.11 -12 0.289 Q15329 G18A Polymorphism NA 0.126 0.04 -16 0.093 Q15334 Q550H Polymorphism 0.140 0.171 0.43 -15 0.118 Q15334 S148G Polymorphism NA 0.476 0.58 -24 0.342 Q15345 V609I Polymorphism 0.146 0.129 NA 27 0.105 Q15361 E473K Polymorphism NA 0.109 0.03 31 0.063 Q15361 R401Q Polymorphism NA 0.046 NA 13 0.033 Q15375 I138V Polymorphism 0.221 0.320 0.28 14 0.272 Q15375 P278S Polymorphism 0.177 0.288 0.14 -17 0.163 Q15388 V134L Polymorphism 0.314 0.080 0.57 0 0.114 Q15392 E191K Disease 0.468 0.910 0.10 55 0.891 Q15392 K306N Disease 0.276 0.326 0.22 5 0.340 Q15392 N294T Disease 0.576 0.711 0.02 23 0.539 Q15392 Y471S Disease 0.390 0.963 0.00 49 0.878 Q15397 S13N Polymorphism NA 0.092 0.00 -20 0.067 Q15397 I264V Polymorphism 0.365 0.099 0.10 -9 0.208 Q15397 R289P Polymorphism 0.166 0.500 0.28 43 0.262 Q15397 R480Q Polymorphism 0.165 0.039 0.26 -16 0.060 Q15398 G69E Polymorphism NA 0.028 NA -4 0.028 Q15398 Q324H Polymorphism NA 0.124 NA 40 0.134 Q15399 H118Y Polymorphism 0.162 0.529 0.66 20 0.258 Q15399 H305L Polymorphism NA 0.211 0.01 34 0.352 Q15399 L631R Polymorphism 0.588 0.384 0.00 0 0.605 Q15399 P733L Polymorphism 0.820 0.340 0.00 33 0.663 Q15399 S602I Polymorphism 0.602 0.153 0.40 -27 0.139 Q15413 I358T Polymorphism 0.296 0.290 0.03 35 0.404 Q15413 E1380G Polymorphism 0.453 0.485 0.02 43 0.540 Q15418 K335T Polymorphism 0.183 0.128 0.53 -8 0.128 Q15431 E805D Polymorphism 0.123 0.164 0.28 0 0.143 Q15436 F382L Disease 0.676 0.902 0.22 26 0.696 Q15436 L211V Polymorphism 0.183 0.112 0.34 6 0.137 Q15437 P433L Polymorphism 0.340 0.299 0.32 10 0.439 Q15465 R6T Disease NA 0.192 0.14 15 0.277 Q15465 D88V Disease 0.919 0.926 0.00 47 0.901 Q15465 G27A Disease 0.809 0.723 0.00 51 0.916 Q15465 G31R Disease 0.866 0.784 0.00 32 0.820 Q15465 A110D Disease 0.852 0.971 0.00 53 0.943 Q15465 A226T Disease 0.357 0.541 0.24 -6 0.455 Q15465 A373T Disease 0.703 0.928 0.01 48 0.874 Q15465 A383T Disease 0.225 0.213 0.37 -9 0.231 Q15465 C183F Disease 0.885 0.952 0.00 47 0.901 Q15465 D222N Disease 0.515 0.785 0.01 32 0.611 Q15465 E188Q Disease 0.551 0.634 0.02 9 0.548 Q15465 G290D Disease NA 0.145 0.86 17 0.241 Q15465 H140P Disease 0.918 0.987 0.00 57 0.949 Q15465 H140Q Disease 0.894 0.949 0.00 60 0.956 Q15465 I111F Disease 0.569 0.873 0.07 41 0.861 Q15465 I111N Disease 0.778 0.917 0.00 40 0.871 Q15465 I354T Disease 0.463 0.395 0.01 32 0.565 Q15465 L271P Disease 0.926 0.991 0.00 38 0.912 Q15465 N115K Disease 0.409 0.978 0.00 40 0.775 Q15465 P347Q Disease 0.935 0.798 0.00 57 0.941 Q15465 P424A Disease 0.107 0.234 0.46 -15 0.187 Q15465 Q100H Disease 0.470 0.542 0.00 26 0.745 Q15465 R381P Disease 0.899 0.936 0.00 69 0.951 Q15465 S236R Disease 0.518 0.938 0.00 56 0.841 Q15465 S436L Disease 0.052 0.681 0.02 15 0.616 Q15465 T150R Disease 0.859 0.973 0.00 62 0.950 Q15465 T267I Disease 0.832 0.939 0.00 66 0.948 Q15465 V224E Disease 0.894 0.918 0.00 55 0.947 Q15465 V332A Disease 0.448 0.796 0.00 23 0.795 Q15465 W117G Disease 0.900 0.961 0.00 55 0.953 Q15465 W117R Disease 0.931 0.964 0.00 63 0.957 Q15466 G171A Polymorphism 0.782 0.166 1.00 6 0.162 Q15468 H984R Polymorphism 0.060 0.081 0.47 26 0.067 Q15468 A1145V Polymorphism 0.076 0.056 0.79 17 0.070 Q15475 R110W Disease 0.995 0.954 0.00 45 0.941 Q15475 Y129C Disease 0.982 0.825 0.18 59 0.944 Q15477 V917M Polymorphism 0.512 0.601 0.12 -9 0.503 Q15485 A258S Polymorphism 0.511 0.739 0.00 41 0.587 Q15517 M18L Polymorphism 0.052 0.349 0.00 -73 0.358 Q15517 D527N Polymorphism 0.104 0.091 0.48 -30 0.044 Q15517 S408A Polymorphism 0.079 0.107 0.00 26 0.178 Q15517 S410L Polymorphism 0.037 0.099 0.02 30 0.165 Q15526 G124E Disease 0.970 0.880 0.00 63 0.950 Q15526 G124R Disease 0.975 0.882 0.00 62 0.951 Q15526 I246T Disease 0.261 0.753 0.02 43 0.696 Q15526 Y274D Disease 0.955 0.973 0.00 68 0.933 Q15527 R221Q Polymorphism NA 0.065 NA -23 0.017 Q15542 S130A Polymorphism NA 0.049 NA 17 0.038 Q15545 S178R Polymorphism 0.315 0.617 0.25 8 0.460 Q15554 S413G Polymorphism 0.255 0.212 0.19 17 0.272 Q15555 Y162C Polymorphism 0.900 0.710 0.00 21 0.862 Q15561 P323S Polymorphism 0.165 0.049 0.77 -44 0.059 Q15569 G574S Polymorphism 0.083 0.237 0.96 34 0.114 Q15572 A591G Polymorphism NA 0.408 0.00 29 0.223 Q15572 G523R Polymorphism NA 0.264 0.00 47 0.159 Q15572 H518Y Polymorphism NA 0.317 0.00 48 0.419 Q15572 P793L Polymorphism NA 0.133 0.00 18 0.055 Q15572 P808S Polymorphism NA 0.115 0.35 -6 0.087 Q15572 R816H Polymorphism NA 0.250 0.00 19 0.148 Q15572 S304F Polymorphism NA 0.092 NA 20 0.045 Q15573 I98M Polymorphism NA 0.163 NA 22 0.122 Q15582 A546D Disease 0.769 0.956 0.00 55 0.924 Q15582 A546T Disease 0.585 0.935 0.00 39 0.866 Q15582 F540S Disease 0.825 0.940 0.00 46 0.896 Q15582 G623D Disease 0.823 0.927 0.02 70 0.943 Q15582 H572R Disease 0.731 0.911 0.00 73 0.920 Q15582 H626P Disease 0.610 0.969 0.01 53 0.907 Q15582 H626R Disease 0.392 0.939 0.02 59 0.908 Q15582 L509R Disease 0.846 0.889 0.01 64 0.933 Q15582 L518P Disease 0.781 0.987 0.01 61 0.929 Q15582 L518R Disease 0.700 0.976 0.01 61 0.925 Q15582 L527R Disease 0.863 0.966 0.00 66 0.943 Q15582 L569R Disease 0.700 0.947 0.01 64 0.936 Q15582 N622K Disease 0.667 0.938 0.05 73 0.935 Q15582 P501T Disease 0.635 0.688 0.07 42 0.714 Q15582 P551Q Disease 0.748 0.834 0.45 33 0.862 Q15582 R124C Disease 0.840 0.345 0.08 35 0.569 Q15582 R124H Disease 0.666 0.221 0.24 33 0.464 Q15582 R124L Disease 0.585 0.304 0.41 25 0.397 Q15582 R124S Disease 0.544 0.326 0.57 25 0.407 Q15582 R555Q Disease 0.203 0.456 0.50 34 0.356 Q15582 R555W Disease 0.561 0.642 0.05 36 0.714 Q15582 R666S Disease 0.223 0.197 0.55 18 0.133 Q15582 T538R Disease 0.448 0.955 0.00 75 0.938 Q15582 V505D Disease 0.732 0.872 0.00 62 0.906 Q15583 P192R Disease 0.992 0.860 0.00 65 0.959 Q15583 P289S Polymorphism 0.306 0.175 0.20 20 0.168 Q15583 P292L Polymorphism 0.690 0.117 0.13 6 0.156 Q15583 Q236L Disease 0.627 0.316 0.10 23 0.560 Q15583 S157C Disease NA 0.243 0.18 28 0.393 Q15583 S291F Disease 0.648 0.180 0.28 37 0.232 Q15583 T280A Disease 0.164 0.070 0.41 13 0.073 Q155Q3 K300R Polymorphism NA 0.069 0.02 -65 0.114 Q15612 Q24R Polymorphism 0.528 0.882 0.02 32 0.597 Q15612 I163M Polymorphism 0.185 0.179 1.00 -19 0.118 Q15612 T240A Polymorphism 0.478 0.862 0.00 58 0.901 Q15615 R54Q Polymorphism 0.355 0.500 0.34 24 0.459 Q15617 A247V Polymorphism 0.764 0.909 0.04 3 0.702 Q15619 T209M Polymorphism 0.570 0.363 0.06 -19 0.582 Q15643 V795L Polymorphism NA 0.040 0.77 -18 0.034 Q15643 E1749A Polymorphism 0.736 0.090 0.06 27 0.283 Q15643 I1040V Polymorphism NA 0.055 0.80 -44 0.035 Q15643 R1576H Polymorphism 0.444 0.214 0.03 37 0.266 Q15643 R1752K Polymorphism 0.137 0.024 0.16 -41 0.014 Q15643 T1846I Polymorphism 0.550 0.559 NA 27 0.724 Q15646 N341I Polymorphism 0.250 0.249 0.22 31 0.318 Q15648 P753T Polymorphism NA 0.138 0.23 10 0.123 Q15652 A272T Polymorphism NA 0.049 0.06 20 0.033 Q15652 E394D Polymorphism NA 0.111 0.07 15 0.038 Q15652 S464T Polymorphism NA 0.095 0.11 18 0.083 Q15652 D2400E Polymorphism 0.178 0.133 0.97 6 0.118 Q15652 N1393Y Polymorphism 0.281 0.195 NA 37 0.208 Q15653 R339W Polymorphism 0.504 0.282 0.02 20 0.316 Q15654 L296F Polymorphism 0.384 0.873 0.68 45 0.799 Q15654 V230I Polymorphism 0.078 0.190 0.44 -15 0.137 Q15661 A18V Polymorphism 0.019 0.493 0.32 -51 0.198 Q15661 G23V Polymorphism 0.058 0.609 0.39 9 0.197 Q15661 N132K Polymorphism 0.176 0.189 0.94 23 0.233 Q15661 P170S Polymorphism 0.794 0.152 0.38 -14 0.290 Q15661 R216Q Polymorphism 0.244 0.134 0.58 -2 0.134 Q15661 T141A Polymorphism 0.161 0.189 0.21 -3 0.131 Q15661 T215S Polymorphism 0.095 0.129 0.63 -44 0.109 Q15672 A186T Disease 0.516 0.781 0.08 50 0.663 Q15672 I156V Disease 0.344 0.746 0.00 38 0.677 Q15672 L131P Disease 0.996 0.989 0.00 69 0.949 Q15672 Q119P Disease 0.871 0.890 0.08 41 0.888 Q15672 S188L Disease 0.496 0.715 0.03 46 0.715 Q15678 V505F Polymorphism NA 0.146 0.01 41 0.083 Q15714 P652S Polymorphism NA 0.119 0.64 27 0.110 Q15726 Q36R Polymorphism NA 0.077 0.00 0 0.113 Q15738 A105V Disease 0.949 0.854 0.02 27 0.851 Q15738 G205S Disease 0.980 0.886 0.00 56 0.940 Q15743 R53Q Polymorphism 0.395 0.566 0.33 30 0.500 Q15746 D914E Polymorphism 0.282 0.209 0.67 30 0.219 Q15746 P336L Polymorphism 0.057 0.190 0.59 33 0.200 Q15746 P443S Polymorphism 0.681 0.670 0.43 55 0.633 Q15746 R378H Polymorphism 0.238 0.072 0.11 27 0.205 Q15746 T276A Polymorphism 0.236 0.182 0.77 32 0.264 Q15746 T692M Polymorphism 0.390 0.338 0.28 31 0.442 Q15746 V709M Polymorphism 0.369 0.382 0.11 40 0.446 Q15746 V877M Polymorphism 0.485 0.098 0.22 43 0.104 Q15746 A1527V Polymorphism 0.923 0.434 0.24 -1 0.657 Q15751 G1411V Polymorphism NA 0.078 NA 40 0.061 Q15751 G3517R Polymorphism NA 0.267 0.00 51 0.256 Q15751 H1447N Polymorphism NA 0.195 NA 17 0.163 Q15751 L1278F Polymorphism NA 0.272 NA 25 0.145 Q15751 S1572A Polymorphism NA 0.139 NA 35 0.161 Q15751 S3152F Polymorphism NA 0.133 NA 34 0.126 Q15758 P17A Polymorphism NA 0.208 0.39 18 0.181 Q15759 R275H Polymorphism NA 0.705 0.04 -1 0.486 Q15768 R166Q Polymorphism 0.226 0.163 0.06 43 0.354 Q15772 R934C Polymorphism NA 0.461 0.03 37 0.516 Q15772 R966Q Polymorphism NA 0.491 0.55 52 0.241 Q15772 A1135V Polymorphism NA 0.158 0.15 27 0.130 Q15772 H3079R Polymorphism 0.298 0.500 0.53 24 0.343 Q15772 P1103L Polymorphism NA 0.407 0.02 14 0.360 Q15772 P2189L Polymorphism 0.314 0.139 0.36 1 0.138 Q15776 P163L Polymorphism 0.572 0.196 0.58 -5 0.207 Q15782 A182V Polymorphism 0.318 0.507 0.01 2 0.357 Q15788 V1238I Polymorphism 0.083 0.046 0.12 -3 0.061 Q15800 N124S Polymorphism 0.195 0.731 0.73 10 0.357 Q15813 S333T Polymorphism 0.248 0.327 0.40 13 0.346 Q15813 V205A Polymorphism 0.667 0.105 1.00 35 0.120 Q15814 A279T Polymorphism 0.507 0.507 0.03 37 0.762 Q15814 P169S Polymorphism 0.322 0.128 0.19 -24 0.175 Q15814 P180S Polymorphism 0.119 0.128 0.81 -43 0.113 Q15819 D40H Polymorphism 0.896 0.949 0.00 38 0.912 Q15819 E36G Polymorphism 0.474 0.749 0.44 7 0.726 Q15819 P78Q Polymorphism 0.927 0.945 0.00 49 0.949 Q15822 I279N Disease 0.906 0.702 0.00 37 0.853 Q15831 L67P Disease NA 0.834 0.09 36 0.824 Q15831 D194N Disease 0.902 0.914 0.00 68 0.798 Q15831 G163D Disease 0.682 0.858 0.00 49 0.791 Q15831 P315S Disease 0.063 0.391 0.20 -2 0.209 Q15831 R297K Disease 0.999 0.945 0.00 70 0.944 Q15831 W239C Disease 0.984 0.924 0.00 71 0.930 Q15835 P391H Disease 0.975 0.915 0.00 73 0.825 Q15835 V380D Disease 0.672 0.837 0.00 54 0.749 Q15842 V334A Polymorphism 0.202 0.217 0.50 -23 0.161 Q15848 R112C Disease NA 0.773 0.02 50 0.850 Q15848 R221S Polymorphism 0.067 0.490 0.42 26 0.083 Q15848 Y111H Polymorphism NA 0.278 0.60 15 0.211 Q15849 A880T Polymorphism NA 0.310 0.64 -12 0.356 Q15849 G443S Polymorphism 0.192 0.042 0.78 -25 0.031 Q15858 I859T Disease 0.763 0.404 0.00 45 0.651 Q15858 L869H Disease 0.950 0.586 0.00 51 0.904 Q15858 M932L Polymorphism 0.467 0.612 0.26 45 0.576 Q15858 S241T Disease 0.711 0.638 0.02 31 0.698 Q15858 F1460V Disease 0.998 0.706 0.00 62 0.973 Q15858 F1473V Disease 0.872 0.750 0.00 55 0.857 Q15858 I1472T Disease 0.763 0.472 0.01 49 0.640 Q15858 M1638K Disease 0.845 0.714 0.01 53 0.914 Q15858 R1007C Disease 0.446 0.754 0.20 1 0.488 Q15858 T1475I Disease 0.891 0.410 0.00 30 0.631 Q15858 V1309D Disease 0.923 0.568 0.00 57 0.908 Q15858 V1309F Disease 0.842 0.557 0.00 45 0.838 Q15858 V1310F Disease 0.874 0.734 0.00 50 0.926 Q15878 D859E Polymorphism NA 0.101 1.00 -44 0.089 Q15884 T233I Polymorphism NA 0.188 0.05 6 0.245 Q15910 D185H Polymorphism 0.355 0.250 0.00 31 0.407 Q15911 T428P Polymorphism NA 0.123 0.00 40 0.155 Q15911 A3374V Polymorphism NA 0.139 0.00 27 0.173 Q15911 P3421A Polymorphism NA 0.058 0.01 10 0.104 Q15928 K124E Polymorphism 0.333 0.672 0.63 -7 0.438 Q15928 K358N Polymorphism 0.651 0.372 0.02 18 0.639 Q15935 G460R Polymorphism 0.891 0.803 0.06 47 0.885 Q15937 R51G Polymorphism 0.303 0.460 0.00 26 0.481 Q15937 S401N Polymorphism 0.478 0.221 0.34 -1 0.293 Q15942 H223L Polymorphism 0.086 0.221 0.06 42 0.310 Q16082 G111S Polymorphism 0.505 0.868 0.07 49 0.846 Q16099 M824T Polymorphism NA 0.625 0.03 2 0.490 Q16134 H94R Polymorphism 0.181 0.266 0.59 -4 0.162 Q16236 S99P Polymorphism 0.471 0.108 0.26 -61 0.087 Q16281 P48L Polymorphism NA 0.054 0.30 -14 0.064 Q16281 A469T Disease 0.747 0.402 0.00 39 0.626 Q16281 C191Y Disease 0.359 0.790 0.00 29 0.755 Q16281 C510S Disease 0.958 0.524 0.00 50 0.891 Q16281 D162V Disease 0.654 0.329 0.00 54 0.640 Q16281 D260N Disease 0.613 0.800 0.01 62 0.904 Q16281 D485V Disease 0.474 0.365 0.01 46 0.542 Q16281 E194K Disease 0.562 0.648 0.25 36 0.499 Q16281 E228K Disease 0.530 0.273 0.04 61 0.796 Q16281 E590K Disease 0.584 0.310 0.04 30 0.601 Q16281 E593K Disease 0.318 0.539 0.04 14 0.523 Q16281 F249S Disease 0.733 0.915 0.00 59 0.927 Q16281 F380S Disease 0.853 0.582 0.00 39 0.812 Q16281 F547L Disease 0.903 0.892 0.00 61 0.823 Q16281 G267D Disease 0.305 0.692 0.12 49 0.592 Q16281 G513E Disease 0.682 0.908 0.00 62 0.770 Q16281 G516E Disease 0.748 0.807 0.00 49 0.882 Q16281 G525D Disease 0.999 0.946 0.00 76 0.946 Q16281 G548R Disease 0.999 0.913 0.00 79 0.713 Q16281 G557R Disease 0.848 0.766 0.00 55 0.886 Q16281 I522T Disease 0.706 0.844 0.00 56 0.884 Q16281 L186F Disease 0.548 0.559 0.03 37 0.623 Q16281 M406T Disease 0.394 0.795 0.06 38 0.648 Q16281 N182Y Disease 0.898 0.881 0.00 53 0.925 Q16281 N471S Disease 0.260 0.245 0.26 17 0.329 Q16281 P163L Disease 0.692 0.912 0.09 53 0.907 Q16281 P372S Disease 0.969 0.500 0.00 58 0.925 Q16281 R223W Disease 0.940 0.907 0.00 63 0.936 Q16281 R277C Disease 0.987 0.957 0.00 63 0.949 Q16281 R277H Disease 0.972 0.855 0.00 64 0.942 Q16281 R283Q Disease 0.830 0.697 0.04 59 0.880 Q16281 R283W Disease 0.970 0.887 0.01 55 0.932 Q16281 R410W Disease 0.906 0.818 0.00 49 0.866 Q16281 R427C Disease 0.905 0.363 0.01 55 0.696 Q16281 R436W Disease 0.941 0.909 0.00 58 0.908 Q16281 R439W Disease 0.865 0.662 0.01 44 0.822 Q16281 R563H Disease 0.658 0.730 0.00 57 0.796 Q16281 R569H Disease 0.743 0.898 0.12 52 0.796 Q16281 S341P Disease 0.121 0.721 0.11 24 0.187 Q16281 S401P Disease 0.694 0.860 0.04 63 0.839 Q16281 T224R Disease 0.565 0.824 0.07 68 0.906 Q16281 T291R Disease 0.752 0.482 0.06 57 0.782 Q16281 T369S Disease 0.323 0.105 0.05 38 0.307 Q16281 T565M Disease 0.782 0.520 0.00 51 0.819 Q16281 V529M Disease 0.943 0.851 0.00 39 0.866 Q16281 Y181C Disease 0.944 0.929 0.00 57 0.944 Q16281 Y263D Disease 0.526 0.831 0.00 66 0.910 Q16281 Y573C Disease 0.945 0.933 0.00 60 0.935 Q16288 E781K Polymorphism 0.475 0.328 0.26 -18 0.299 Q16288 R678Q Polymorphism 0.682 0.897 0.00 66 0.926 Q16322 S258N Polymorphism 0.054 0.210 0.17 17 0.206 Q16348 R57H Polymorphism 0.952 0.895 0.00 60 0.935 Q16348 Y73C Polymorphism 0.666 0.860 0.13 -5 0.809 Q16348 A609G Polymorphism 0.285 0.435 0.21 26 0.421 Q16348 L350F Polymorphism 0.102 0.776 0.41 -4 0.181 Q16348 M704L Polymorphism 0.037 0.150 0.93 -40 0.069 Q16348 P409S Polymorphism NA 0.300 0.07 47 0.446 Q16352 T92S Polymorphism 0.578 0.148 0.43 -27 0.180 Q16363 L492H Polymorphism NA 0.494 0.01 47 0.691 Q16363 N1549S Polymorphism 0.138 0.455 0.77 37 0.285 Q16394 Q27K Disease NA 0.212 1.00 -18 0.298 Q16394 A486V Disease 0.245 0.072 0.61 -13 0.097 Q16394 D164H Disease 0.780 0.566 0.14 49 0.671 Q16394 G339D Disease 0.816 0.910 0.53 70 0.698 Q16394 N316S Disease 0.535 0.269 1.00 3 0.439 Q16394 P496L Disease 0.333 0.154 0.14 10 0.173 Q16394 R280G Disease 0.696 0.881 0.04 48 0.825 Q16394 R280S Disease 0.650 0.855 0.05 35 0.707 Q16394 R340C Disease 0.888 0.639 0.15 38 0.813 Q16394 R340H Disease 0.750 0.403 0.48 25 0.498 Q16394 R340L Disease 0.686 0.500 0.64 29 0.669 Q16394 R340S Disease 0.650 0.406 0.69 38 0.473 Q16445 P404S Polymorphism 0.071 0.141 0.64 -22 0.092 Q16512 I718V Polymorphism 0.151 0.037 0.94 -43 0.048 Q16512 L555I Polymorphism NA 0.202 0.19 6 0.258 Q16512 R635Q Polymorphism 0.220 0.350 0.02 45 0.470 Q16512 V901I Polymorphism 0.161 0.198 0.11 13 0.239 Q16513 E94D Polymorphism NA 0.248 0.60 -15 0.218 Q16513 Q655R Polymorphism 0.306 0.596 0.06 22 0.534 Q16518 G40S Disease 0.988 0.898 0.00 68 0.951 Q16518 H68Y Disease 0.910 0.846 0.02 52 0.885 Q16518 L22P Disease 0.758 0.566 0.28 2 0.702 Q16518 R44Q Disease 0.924 0.912 0.00 73 0.942 Q16518 R91Q Disease 0.462 0.231 0.56 -9 0.238 Q16518 R91W Disease 0.865 0.460 0.05 30 0.681 Q16518 A132T Disease 0.280 0.525 0.54 6 0.352 Q16518 A393G Disease 0.389 0.835 0.19 23 0.602 Q16518 E417Q Disease 0.923 0.929 0.03 65 0.944 Q16518 H182Y Disease 0.908 0.890 0.19 46 0.893 Q16518 L341S Disease 0.208 0.805 0.15 24 0.470 Q16518 N321K Disease 0.149 0.488 0.22 11 0.191 Q16518 P363T Disease 0.569 0.226 0.24 7 0.466 Q16518 R515W Disease 0.985 0.942 0.02 61 0.949 Q16518 V287F Disease 0.466 0.416 0.05 -7 0.496 Q16518 V452G Disease 0.565 0.777 0.00 25 0.677 Q16518 Y144D Disease 0.690 0.812 0.03 52 0.889 Q16518 Y368H Disease 0.542 0.524 0.00 56 0.713 Q16518 Y431C Disease 0.794 0.882 0.02 62 0.869 Q16538 R459G Polymorphism NA 0.178 0.00 37 0.223 Q16539 D343G Polymorphism NA 0.202 0.21 11 0.337 Q16540 G32S Polymorphism NA 0.456 0.52 12 0.277 Q16543 G360E Polymorphism NA 0.088 0.00 2 0.119 Q16548 C19Y Polymorphism 0.227 0.091 0.99 -7 0.033 Q16548 G82D Polymorphism 0.202 0.677 0.00 51 0.772 Q16548 N39K Polymorphism 0.070 0.077 0.26 -24 0.033 Q16548 E117D Polymorphism 0.143 0.196 0.42 -22 0.115 Q16549 H708Y Polymorphism NA 0.116 0.21 30 0.098 Q16549 L688V Polymorphism NA 0.250 0.14 43 0.184 Q16549 R700M Polymorphism NA 0.187 0.00 41 0.207 Q16549 S689N Polymorphism NA 0.246 0.00 42 0.212 Q16557 K199N Polymorphism 0.096 0.511 1.00 -10 0.029 Q16558 V110L Polymorphism 0.105 0.053 0.83 -18 0.014 Q16566 Q465R Polymorphism NA 0.243 0.28 24 0.263 Q16568 L113M Polymorphism 0.412 0.249 0.00 41 0.435 Q16570 R89C Polymorphism 0.785 0.336 0.05 60 0.621 Q16570 A100T Polymorphism 0.190 0.118 0.02 9 0.114 Q16570 L203Q Polymorphism 0.528 0.210 0.30 29 0.154 Q16572 A13P Polymorphism 0.204 0.327 0.00 53 0.332 Q16572 R11Q Polymorphism 0.111 0.077 0.34 3 0.036 Q16572 R29W Polymorphism 0.628 0.765 0.01 41 0.683 Q16581 V136A Polymorphism 0.411 0.286 0.10 29 0.389 Q16584 A282G Polymorphism 0.671 0.187 0.34 36 0.434 Q16584 P252H Polymorphism NA 0.099 0.13 3 0.221 Q16585 R91C Disease 0.921 0.813 NA 43 0.876 Q16585 R91L Disease 0.771 0.787 NA 29 0.838 Q16585 R91P Disease 0.841 0.936 NA 53 0.937 Q16585 G167S Disease 0.482 0.207 NA 7 0.201 Q16585 I119F Disease 0.520 0.316 NA 49 0.474 Q16585 L108R Disease 0.483 0.590 NA 41 0.724 Q16585 M100K Disease 0.210 0.523 NA 53 0.715 Q16585 T151R Disease 0.327 0.329 NA 43 0.519 Q16586 A93V Disease 0.228 0.271 0.08 21 0.306 Q16586 D97G Disease 0.422 0.528 0.17 20 0.670 Q16586 G68E Disease 0.667 0.747 0.00 34 0.830 Q16586 G91R Disease 0.840 0.929 0.00 67 0.950 Q16586 L31P Disease 0.695 0.798 0.20 14 0.836 Q16586 L89P Disease 0.857 0.888 0.00 50 0.925 Q16586 P30L Disease 0.068 0.467 1.00 11 0.262 Q16586 R34C Disease 0.766 0.443 0.10 12 0.572 Q16586 R34H Disease 0.555 0.325 0.18 -3 0.465 Q16586 R74W Disease 0.823 0.291 0.04 32 0.531 Q16586 R77C Disease 0.589 0.785 0.01 46 0.847 Q16586 R98C Disease 0.766 0.328 0.10 25 0.513 Q16586 R98H Disease 0.555 0.192 0.18 12 0.367 Q16586 Y62H Disease 0.491 0.699 0.01 53 0.833 Q16586 E137G Disease 0.522 0.486 0.00 37 0.698 Q16586 E137K Disease 0.441 0.695 0.00 45 0.677 Q16586 I103T Disease 0.510 0.801 0.00 32 0.747 Q16586 I124T Disease 0.510 0.575 0.00 45 0.698 Q16586 L158F Disease 0.484 0.305 0.00 22 0.503 Q16586 L173P Disease 0.695 0.805 0.01 28 0.841 Q16586 P205H Disease 0.735 0.337 0.01 32 0.561 Q16586 P228Q Disease 0.763 0.420 0.00 34 0.594 Q16586 R284C Disease 0.849 0.793 0.00 61 0.933 Q16586 V175A Disease 0.264 0.184 0.02 37 0.318 Q16586 V196I Disease 0.296 0.399 0.00 23 0.310 Q16586 V242A Disease 0.306 0.270 0.03 32 0.374 Q16586 V247M Disease 0.445 0.160 0.02 25 0.277 Q16587 E117K Polymorphism 0.292 0.222 0.73 -9 0.264 Q16589 L4V Polymorphism NA 0.071 0.04 -3 0.085 Q16594 T6M Polymorphism NA 0.027 0.12 -8 0.061 Q16595 D122Y Disease NA 0.789 0.00 62 0.873 Q16595 G130V Disease NA 0.972 0.00 60 0.907 Q16595 I154F Disease NA 0.873 0.00 45 0.855 Q16595 L106S Disease NA 0.891 0.00 36 0.813 Q16595 L182F Disease NA 0.900 0.43 37 0.798 Q16595 L198R Disease NA 0.636 0.00 38 0.736 Q16595 R165C Disease NA 0.968 0.00 55 0.889 Q16595 S202C Polymorphism NA 0.136 0.01 -4 0.222 Q16595 W155R Disease NA 0.956 0.00 65 0.937 Q16600 A172G Polymorphism 0.596 0.249 0.22 23 0.119 Q16600 C209G Polymorphism 0.957 0.325 0.01 73 0.871 Q16600 D266E Polymorphism 0.556 0.264 0.61 -32 0.369 Q16602 N8Y Polymorphism NA 0.145 0.36 -9 0.092 Q16602 F16L Polymorphism NA 0.103 0.74 -60 0.076 Q16602 R274I Polymorphism 0.604 0.734 0.01 61 0.883 Q16609 T91M Polymorphism 0.092 0.198 0.20 9 0.198 Q16610 F167I Disease NA 0.482 NA 30 0.566 Q16610 G528R Polymorphism NA 0.263 NA 60 0.284 Q16610 S535F Polymorphism NA 0.078 NA -2 0.059 Q16613 R15C Polymorphism 0.472 0.088 0.13 21 0.092 Q16619 A92T Polymorphism 0.340 0.073 0.51 26 0.051 Q16620 G545V Polymorphism 0.853 0.934 0.00 66 0.935 Q16626 A183D Polymorphism 0.372 0.255 NA 16 0.205 Q16627 K61E Polymorphism 0.300 0.631 0.33 6 0.470 Q16633 T141A Polymorphism NA 0.272 NA 15 0.171 Q16635 R94S Disease 0.930 0.949 0.00 63 0.951 Q16637 A2G Disease NA 0.124 0.00 -20 0.226 Q16637 D30N Disease 0.431 0.545 0.00 11 0.471 Q16637 D44V Disease 0.817 0.637 0.00 22 0.777 Q16637 G95R Disease 0.976 0.773 0.00 49 0.938 Q16637 A111G Disease 0.632 0.665 0.00 27 0.776 Q16637 G275S Disease 0.614 0.745 0.00 55 0.882 Q16637 G279C Disease 0.904 0.654 0.00 49 0.898 Q16637 G279V Disease 0.698 0.727 0.00 52 0.882 Q16637 I116F Disease 0.429 0.788 0.02 27 0.764 Q16637 P245L Disease 0.515 0.262 0.00 19 0.516 Q16637 Q136E Disease 0.431 0.474 0.13 7 0.564 Q16637 S262G Disease 0.648 0.249 0.00 36 0.541 Q16637 S262I Disease 0.750 0.474 0.00 37 0.686 Q16637 T274I Disease 0.609 0.816 0.00 42 0.832 Q16637 Y272C Disease 0.963 0.816 0.00 57 0.945 Q16643 I446V Polymorphism 0.222 0.062 0.97 14 0.024 Q16643 S553P Polymorphism 0.102 0.130 0.10 -23 0.087 Q16644 D276Y Polymorphism 0.334 0.348 0.03 38 0.512 Q16647 P500S Polymorphism NA 0.274 0.00 16 0.324 Q16647 R236C Polymorphism 0.815 0.288 0.01 36 0.582 Q16647 S118R Polymorphism 0.457 0.603 0.25 27 0.620 Q16650 H289Q Polymorphism 0.998 0.932 0.00 45 0.916 Q16654 A17V Polymorphism NA 0.246 0.72 -16 0.227 Q16654 D109G Polymorphism 0.459 0.724 0.21 19 0.542 Q16659 L290V Polymorphism NA 0.252 0.15 -22 0.288 Q16661 P11T Polymorphism 0.098 0.094 0.63 -11 0.031 Q16665 T796A Polymorphism 0.362 0.264 0.00 41 0.426 Q16666 D103H Polymorphism 0.198 0.096 0.21 12 0.167 Q16666 K202E Polymorphism 0.089 0.452 0.68 5 0.211 Q16666 S179T Polymorphism 0.113 0.148 1.00 -15 0.077 Q16667 C79Y Disease 0.401 0.842 0.05 39 0.751 Q16667 D94V Disease 0.652 0.435 0.04 16 0.487 Q16667 F78L Disease 0.241 0.154 0.28 -1 0.130 Q16667 L95F Disease 0.156 0.072 0.12 12 0.080 Q16667 N91K Disease 0.160 0.185 0.21 -5 0.214 Q16667 W31R Disease NA 0.788 NA 52 0.843 Q16667 I108V Disease 0.107 0.310 0.12 8 0.188 Q16667 K195I Disease 0.377 0.208 0.01 0 0.218 Q16667 N187S Disease 0.322 0.206 0.43 10 0.286 Q16667 S159F Polymorphism 0.544 0.230 0.01 12 0.382 Q16670 E83K Polymorphism 0.769 0.895 0.01 42 0.853 Q16670 R73Q Polymorphism 0.403 0.606 0.31 36 0.521 Q16670 R220S Polymorphism 0.335 0.376 0.76 21 0.363 Q16671 R54C Disease NA 0.360 0.05 65 0.693 Q16671 D426G Disease 0.311 0.175 0.06 19 0.214 Q16671 D491H Disease 0.645 0.581 0.01 55 0.823 Q16671 G142V Disease NA 0.115 0.36 -3 0.189 Q16671 H282Q Disease 0.301 0.323 0.00 27 0.415 Q16671 R406Q Disease 0.052 0.267 0.32 3 0.135 Q16671 R504C Disease 0.802 0.769 0.01 54 0.902 Q16671 V458A Disease 0.265 0.430 0.20 30 0.371 Q16678 G61E Disease 0.998 0.891 0.00 78 0.953 Q16678 L77P Disease 0.686 0.909 0.00 56 0.907 Q16678 Q68R Polymorphism 0.078 0.683 0.56 -12 0.038 Q16678 R48G Polymorphism 0.269 0.530 0.16 47 0.422 Q16678 S28W Disease 0.826 0.571 0.03 30 0.764 Q16678 W57C Disease 0.778 0.734 0.02 66 0.907 Q16678 Y81N Disease 0.963 0.859 0.00 63 0.933 Q16678 A115P Disease 0.499 0.888 0.09 39 0.855 Q16678 A119S Polymorphism 0.125 0.174 0.20 -43 0.128 Q16678 A330F Disease 0.973 0.888 0.00 57 0.937 Q16678 A388T Disease 0.188 0.107 0.54 -34 0.111 Q16678 A443G Disease 0.370 0.097 0.04 -63 0.156 Q16678 D192V Disease 0.576 0.869 0.00 60 0.899 Q16678 D374N Disease 0.415 0.841 0.00 60 0.836 Q16678 D449E Polymorphism 0.274 0.178 0.31 -33 0.198 Q16678 D530G Disease NA 0.255 0.00 2 0.265 Q16678 E229K Disease 0.354 0.466 0.48 -28 0.283 Q16678 E387K Disease 0.999 0.866 0.00 75 0.943 Q16678 E499G Disease NA 0.507 0.20 25 0.484 Q16678 F445C Disease 0.981 0.912 0.00 62 0.944 Q16678 G184S Polymorphism 0.125 0.216 0.52 -35 0.149 Q16678 G232R Disease 0.660 0.757 0.45 32 0.706 Q16678 G365W Disease 0.873 0.877 0.00 37 0.858 Q16678 G466D Disease 0.968 0.920 0.02 75 0.939 Q16678 I399S Disease 0.523 0.433 0.00 45 0.670 Q16678 L345F Disease 0.428 0.272 0.05 -29 0.304 Q16678 M132R Disease 0.143 0.803 0.00 39 0.684 Q16678 N203S Disease 0.921 0.926 0.01 43 0.873 Q16678 N423Y Disease 0.973 0.823 0.00 51 0.920 Q16678 P193L Disease 0.927 0.860 0.14 6 0.829 Q16678 P437L Disease 0.976 0.846 0.00 45 0.905 Q16678 Q144H Polymorphism 0.304 0.297 0.15 4 0.349 Q16678 Q144P Disease 0.372 0.761 0.07 49 0.830 Q16678 Q144R Disease 0.078 0.320 1.00 23 0.223 Q16678 R145W Disease 0.817 0.937 0.00 73 0.943 Q16678 R266L Polymorphism 0.496 0.662 0.24 -2 0.468 Q16678 R368H Disease 0.967 0.867 0.00 43 0.892 Q16678 R390C Disease 0.810 0.860 0.00 74 0.919 Q16678 R390H Disease 0.618 0.853 0.00 77 0.915 Q16678 R390S Disease 0.488 0.867 0.00 69 0.917 Q16678 R444Q Disease 0.936 0.655 0.00 56 0.915 Q16678 R469W Disease 0.842 0.869 0.01 35 0.836 Q16678 R523T Disease NA 0.901 0.00 72 0.916 Q16678 S206N Polymorphism 0.393 0.422 0.04 2 0.233 Q16678 S215I Disease 0.298 0.321 0.01 25 0.498 Q16678 S239R Disease 0.486 0.742 0.07 35 0.559 Q16678 S515L Disease NA 0.156 0.09 -37 0.251 Q16678 V198I Disease 0.051 0.149 0.20 -5 0.146 Q16678 V320L Disease 0.223 0.158 0.42 -48 0.130 Q16678 V364M Disease 0.503 0.623 0.05 27 0.568 Q16678 V409F Disease 0.470 0.357 0.01 -29 0.207 Q16678 V422G Polymorphism 0.573 0.442 0.00 17 0.637 Q16678 V518A Polymorphism NA 0.287 0.01 27 0.391 Q16690 P322L Polymorphism NA 0.511 0.77 4 0.444 Q16696 F453Y Polymorphism 0.379 0.444 0.01 21 0.582 Q16696 R101Q Polymorphism 0.886 0.885 0.00 63 0.936 Q16696 R494C Polymorphism NA 0.952 0.00 68 0.949 Q16696 V323L Polymorphism 0.240 0.723 0.01 20 0.630 Q16698 K333N Polymorphism NA 0.263 0.08 23 0.270 Q16719 K412E Polymorphism 0.147 0.451 1.00 2 0.181 Q16720 I198M Polymorphism 0.446 0.243 0.21 3 0.345 Q16762 E228G Polymorphism 0.769 0.718 0.02 29 0.671 Q16772 I71L Polymorphism 0.424 0.957 0.03 50 0.912 Q16772 N73D Polymorphism 0.345 0.854 0.56 21 0.662 Q16787 P1208T Polymorphism NA 0.782 0.00 52 0.873 Q16787 V1206A Polymorphism NA 0.609 0.26 34 0.478 Q16798 K324N Polymorphism 0.369 0.668 0.17 -33 0.450 Q16799 G247E Polymorphism NA 0.043 0.84 0 0.093 Q16799 I357V Polymorphism NA 0.077 0.46 -5 0.046 Q16816 R323C Polymorphism 0.375 0.865 0.08 30 0.651 Q16819 M634V Polymorphism 0.128 0.083 0.14 37 0.045 Q16819 T726M Polymorphism NA 0.160 0.01 25 0.203 Q16820 P695L Polymorphism 0.398 0.165 1.00 -24 0.025 Q16820 V326M Polymorphism 0.064 0.208 0.37 3 0.099 Q16821 A931E Disease NA 0.222 NA 33 0.099 Q16822 R521H Polymorphism 0.381 0.734 0.16 -6 0.539 Q16825 K906N Polymorphism 0.387 0.095 0.14 1 0.216 Q16828 S144A Polymorphism NA 0.389 0.23 27 0.412 Q16832 M441I Polymorphism NA 0.114 0.02 17 0.096 Q16832 R478C Polymorphism NA 0.151 0.05 10 0.092 Q16836 A40T Disease NA 0.749 0.00 -13 0.308 Q16836 D57E Disease NA 0.751 0.00 17 0.469 Q16836 P258L Disease 0.971 0.902 0.00 46 0.876 Q16836 Q152H Polymorphism 0.609 0.402 0.00 22 0.151 Q16849 S419R Polymorphism NA 0.080 0.54 25 0.051 Q16850 V13A Polymorphism NA 0.211 0.03 -22 0.213 Q16851 M268I Polymorphism 0.283 0.191 1.00 -29 0.139 Q16853 T5R Polymorphism NA 0.433 0.05 32 0.565 Q16853 A408S Polymorphism 0.766 0.821 0.11 25 0.768 Q16853 A582T Polymorphism 0.261 0.398 0.50 -40 0.231 Q16853 A749V Polymorphism 0.089 0.079 1.00 -33 0.064 Q16853 G700S Polymorphism NA 0.557 0.99 -38 0.280 Q16853 H203R Polymorphism 0.076 0.219 0.46 21 0.061 Q16853 I371T Polymorphism 0.380 0.700 0.18 -28 0.507 Q16853 R329Q Polymorphism 0.076 0.518 0.33 0 0.016 Q16853 R441W Polymorphism 0.909 0.795 0.00 43 0.877 Q16854 E227K Disease 0.862 0.896 0.24 44 0.891 Q16854 L250S Disease 0.820 0.781 0.01 38 0.859 Q16854 R142K Disease 0.794 0.931 0.11 69 0.947 Q16864 G24V Polymorphism 0.725 0.989 0.00 67 0.938 Q16873 R142Q Polymorphism 0.104 0.095 0.40 46 0.075 Q16878 T45I Polymorphism 0.117 0.128 0.12 -10 0.124 Q16891 A294V Polymorphism 0.192 0.085 0.23 -35 0.088 Q16891 P124S Polymorphism 0.286 0.188 0.63 -38 0.187 Q17R55 P3S Polymorphism NA 0.047 0.23 -48 0.035 Q17R55 C160R Polymorphism NA 0.073 0.89 -5 0.020 Q17R55 V216I Polymorphism NA 0.070 0.50 -43 0.054 Q17R60 R704W Polymorphism 0.093 0.130 0.13 -20 0.046 Q17R60 R711H Polymorphism 0.391 0.248 0.00 39 0.388 Q17RB8 I265L Polymorphism NA 0.029 1.00 -52 0.023 Q17RF5 P30L Polymorphism NA 0.116 NA 44 0.182 Q17RG1 E750K Polymorphism NA 0.118 0.04 32 0.151 Q17RP2 R59W Polymorphism NA 0.273 0.02 45 0.422 Q17RP2 Q327R Polymorphism 0.410 0.056 1.00 -13 0.021 Q17RQ9 V118L Polymorphism 0.145 0.253 0.20 -22 0.181 Q17RR3 F332L Polymorphism 0.216 0.371 0.82 -5 0.166 Q17RR3 F450Y Polymorphism 0.373 0.778 0.03 54 0.837 Q17RS7 N143S Polymorphism 0.665 0.461 0.09 15 0.587 Q17RW2 I293T Polymorphism NA 0.289 0.52 -6 0.211 Q17RW2 M481L Polymorphism NA 0.444 0.77 8 0.213 Q17RW2 P546S Polymorphism NA 0.422 0.25 8 0.348 Q17RW2 P731S Polymorphism 0.090 0.458 0.37 -4 0.175 Q18PE1 D197N Polymorphism NA 0.607 NA -4 0.476 Q18PE1 G180A Disease NA 0.821 NA 38 0.772 Q18PE1 G461D Polymorphism 0.070 0.259 NA 34 0.189 Q18PE1 P415S Polymorphism 0.460 0.162 NA -16 0.168 Q18PE1 Q296R Polymorphism 0.069 0.116 NA 14 0.094 Q18PE1 R158Q Polymorphism NA 0.678 NA 67 0.885 Q18PE1 R261H Polymorphism 0.514 0.192 NA 49 0.293 Q1ED39 A266V Polymorphism NA 0.063 0.08 -19 0.027 Q1EHB4 V510L Polymorphism NA 0.098 0.71 -50 0.112 Q1HG43 P19L Polymorphism NA 0.194 0.29 -5 0.346 Q1HG44 R100G Polymorphism NA 0.142 1.00 20 0.049 Q1L6U9 G116V Polymorphism NA 0.107 NA -4 0.061 Q1MX18 D333N Polymorphism NA 0.612 NA 16 0.661 Q1X8D7 S744G Polymorphism NA 0.131 NA 39 0.128 Q1ZYL8 A2T Polymorphism NA 0.190 NA -2 0.159 Q1ZYL8 F38L Polymorphism NA 0.277 NA 14 0.091 Q24JP5 A969V Polymorphism 0.361 0.294 0.06 -10 0.417 Q24JQ0 L131F Polymorphism NA 0.046 0.07 -21 0.081 Q27J81 T1135M Polymorphism NA 0.103 0.03 16 0.147 Q29718 N87D Polymorphism 0.328 0.398 0.22 30 0.571 Q29718 T97A Polymorphism 0.412 0.151 0.21 -6 0.238 Q29718 D186G Polymorphism 0.524 0.042 1.00 -23 0.017 Q29718 S101N Polymorphism 0.295 0.142 1.00 -28 0.141 Q29836 M4T Polymorphism 0.121 0.874 0.29 -12 0.230 Q29836 V9L Polymorphism 0.206 0.257 1.00 -76 0.169 Q29836 A93R Polymorphism 0.264 0.521 0.28 2 0.381 Q29836 E69G Polymorphism 0.327 0.252 0.40 -2 0.324 Q29836 I90K Polymorphism 0.277 0.095 0.80 -10 0.161 Q29836 T97A Polymorphism 0.412 0.226 0.21 -9 0.340 Q29836 E100V Polymorphism 0.270 0.083 1.00 -19 0.098 Q29836 S101N Polymorphism 0.295 0.143 1.00 -27 0.141 Q29865 A73E Polymorphism 0.554 0.585 0.07 15 0.611 Q29865 V76M Polymorphism 0.313 0.156 0.51 -40 0.163 Q29865 V319A Polymorphism 0.177 0.402 0.07 -41 0.229 Q29960 A73E Polymorphism 0.554 0.588 0.07 17 0.615 Q29960 V76M Polymorphism 0.313 0.163 0.51 -44 0.169 Q29960 A182V Polymorphism 0.530 0.242 0.02 9 0.553 Q29960 C157W Polymorphism 0.843 0.247 1.00 -16 0.001 Q29960 E201K Polymorphism 0.396 0.704 0.66 14 0.513 Q29960 Q180W Polymorphism 0.193 0.174 0.23 3 0.163 Q29960 V272M Polymorphism 0.800 0.418 0.05 1 0.568 Q29963 A73E Polymorphism 0.554 0.585 0.07 18 0.615 Q29963 A97T Polymorphism 0.412 0.069 1.00 -48 0.031 Q29963 D33Y Polymorphism 0.422 0.356 1.00 -1 0.232 Q29963 E43K Polymorphism 0.440 0.827 0.10 19 0.630 Q29963 V76M Polymorphism 0.313 0.156 0.52 -39 0.164 Q29963 A182V Polymorphism 0.530 0.540 0.04 4 0.525 Q29963 V272M Polymorphism 0.800 0.167 0.08 30 0.363 Q29963 W180L Polymorphism 0.240 0.270 0.83 17 0.239 Q29980 D88G Polymorphism NA 0.531 0.54 25 0.401 Q29980 E39G Polymorphism 0.579 0.180 1.00 20 0.081 Q29980 P68H Polymorphism 0.820 0.860 0.00 36 0.878 Q29980 A383T Polymorphism NA 0.188 0.00 22 0.141 Q29980 D136N Polymorphism 0.739 0.886 0.26 0 0.654 Q29980 E215K Polymorphism 0.215 0.389 0.22 6 0.295 Q29980 I121M Polymorphism 0.411 0.172 0.15 -5 0.201 Q29980 R279K Polymorphism 0.274 0.654 0.46 3 0.440 Q29980 T212I Polymorphism 0.579 0.695 0.00 51 0.870 Q29980 V300A Polymorphism 0.206 0.206 0.74 -28 0.145 Q29983 C59Y Polymorphism 0.461 0.204 0.54 27 0.161 Q29983 R29P Polymorphism 0.812 0.961 0.00 42 0.888 Q29983 V49G Polymorphism 0.599 0.159 1.00 -10 0.139 Q29983 W37G Polymorphism 0.198 0.477 0.02 48 0.260 Q29983 A383T Polymorphism NA 0.187 NA 21 0.090 Q29983 G137R Polymorphism 0.937 0.827 0.18 62 0.920 Q29983 G229S Polymorphism 0.552 0.826 0.08 46 0.747 Q29983 M152V Polymorphism 0.367 0.165 0.47 -8 0.126 Q29983 M174V Polymorphism 0.070 0.354 0.29 20 0.111 Q29983 P294A Polymorphism NA 0.750 0.01 1 0.566 Q29983 Q114R Polymorphism 0.792 0.889 0.04 71 0.917 Q29983 R279S Polymorphism 0.315 0.775 0.43 20 0.598 Q29983 S291G Polymorphism NA 0.264 0.08 17 0.286 Q29983 T147S Polymorphism 0.481 0.381 0.01 29 0.413 Q29983 T236I Polymorphism 0.535 0.802 0.02 9 0.702 Q29983 V165I Polymorphism 0.109 0.069 1.00 -24 0.035 Q29983 V244L Polymorphism 0.344 0.591 0.01 0 0.406 Q29983 Y231C Polymorphism 0.975 0.837 0.00 67 0.948 Q2HXU8 T6N Polymorphism 0.349 0.289 0.27 39 0.361 Q2HXU8 V116L Polymorphism 0.080 0.030 0.53 -32 0.060 Q2I0M5 C95F Disease 0.948 0.900 0.00 59 0.957 Q2I0M5 Q65R Disease 0.797 0.911 0.02 46 0.895 Q2I0M5 C107R Disease 0.942 0.980 0.00 80 0.960 Q2I0M5 C118Y Disease 0.958 0.967 0.00 72 0.965 Q2I0M5 R106Q Polymorphism 0.379 0.256 0.12 -2 0.267 Q2KHM9 E375D Polymorphism NA 0.095 NA 17 0.096 Q2KHM9 E375G Polymorphism NA 0.042 NA 34 0.123 Q2KHM9 H201Q Polymorphism NA 0.037 NA -27 0.019 Q2KHR3 V385I Polymorphism NA 0.029 0.29 -29 0.021 Q2KHR3 N1304D Polymorphism 0.120 0.107 NA 4 0.089 Q2KHT3 G906E Polymorphism 0.423 0.106 0.00 45 0.147 Q2KHT4 F39L Polymorphism NA 0.738 0.65 -11 0.576 Q2LD37 I978T Polymorphism NA 0.269 NA 18 0.353 Q2LD37 T4786A Polymorphism NA 0.066 NA 34 0.076 Q2M1K9 N629S Polymorphism 0.124 0.293 0.49 -1 0.131 Q2M1P5 G1005R Polymorphism 0.052 0.124 0.41 19 0.080 Q2M1V0 P57S Polymorphism NA 0.082 0.85 -45 0.110 Q2M1V0 R83Q Polymorphism 0.419 0.834 0.00 55 0.719 Q2M1Z3 P221L Polymorphism 0.304 0.433 0.08 27 0.340 Q2M1Z3 I1115L Polymorphism 0.308 0.203 NA -4 0.178 Q2M1Z3 T1380I Polymorphism 0.454 0.180 NA 27 0.110 Q2M243 M267T Polymorphism NA 0.031 0.53 -18 0.014 Q2M243 P390L Polymorphism NA 0.094 0.35 12 0.054 Q2M243 T353M Polymorphism NA 0.110 0.05 11 0.111 Q2M296 L45V Polymorphism 0.262 0.139 0.22 -17 0.197 Q2M296 S296C Polymorphism 0.602 0.135 0.06 -21 0.215 Q2M2E5 A57T Polymorphism NA 0.047 NA -8 0.022 Q2M2E5 R101W Polymorphism NA 0.241 NA 41 0.093 Q2M2I5 A115T Polymorphism 0.366 0.120 0.38 31 0.206 Q2M2I5 G250D Polymorphism 0.922 0.887 0.00 27 0.879 Q2M2I5 R366C Polymorphism 0.876 0.867 0.00 7 0.784 Q2M2I5 W418R Polymorphism 0.946 0.232 1.00 -40 0.050 Q2M2I8 P771R Polymorphism NA 0.143 0.00 53 0.180 Q2M2I8 Q533H Polymorphism 0.071 0.330 0.41 28 0.131 Q2M2W7 I92V Polymorphism NA 0.053 NA 11 0.022 Q2M2Z5 H139Q Polymorphism 0.089 0.026 1.00 -22 0.008 Q2M2Z5 M236T Polymorphism 0.143 0.167 0.89 0 0.122 Q2M385 A467T Polymorphism NA 0.170 0.00 6 0.253 Q2M385 P552L Polymorphism NA 0.228 0.00 14 0.423 Q2M385 Q694R Polymorphism NA 0.057 0.06 27 0.044 Q2M3A8 E6A Polymorphism NA 0.063 NA 25 0.049 Q2M3A8 G142V Polymorphism NA 0.301 NA 23 0.076 Q2M3A8 S135F Polymorphism NA 0.160 NA 30 0.061 Q2M3C6 P427L Polymorphism NA 0.045 1.00 -41 0.025 Q2M3C7 G425R Polymorphism NA 0.256 0.13 12 0.136 Q2M3D2 N173D Polymorphism 0.107 0.069 0.86 -7 0.036 Q2M3G0 A470T Polymorphism 0.623 0.204 0.40 -8 0.471 Q2M3G0 Q460H Polymorphism 0.709 0.395 0.10 -25 0.582 Q2M3M2 I269M Polymorphism 0.297 0.142 0.32 -18 0.188 Q2M3M2 M207T Polymorphism 0.287 0.551 0.38 -43 0.240 Q2M3X9 P412L Disease 0.851 0.640 0.05 38 0.825 Q2M3X9 T343M Polymorphism 0.537 0.237 0.00 39 0.655 Q2NKQ1 R873K Polymorphism NA 0.129 0.15 -17 0.190 Q2NL68 S302R Polymorphism 0.228 0.080 0.08 32 0.085 Q2NL82 S386G Polymorphism NA 0.059 0.32 -6 0.082 Q2PPJ7 S492N Polymorphism 0.682 0.101 0.48 19 0.102 Q2PZI1 G502V Polymorphism NA 0.276 0.29 -17 0.206 Q2T9J0 T65A Polymorphism 0.137 0.241 NA -25 0.146 Q2TAA5 N108S Polymorphism 0.185 0.080 1.00 -21 0.047 Q2TAC2 E237Q Polymorphism 0.362 0.054 0.11 4 0.104 Q2TAC2 Q321R Polymorphism 0.271 0.200 0.35 6 0.219 Q2TAC2 R775G Polymorphism NA 0.126 NA 32 0.102 Q2TAC6 R807H Polymorphism NA 0.146 0.00 40 0.143 Q2TAK8 G219R Polymorphism NA 0.020 0.65 0 0.021 Q2TAL6 A120G Polymorphism NA 0.068 0.19 26 0.015 Q2TAZ0 G948R Polymorphism 0.566 0.138 0.01 40 0.165 Q2TB10 L102V Polymorphism 0.116 0.075 0.04 7 0.073 Q2TB90 D54G Polymorphism NA 0.516 0.07 47 0.625 Q2TB90 L204P Polymorphism 0.568 0.784 0.02 37 0.848 Q2TB90 N917K Polymorphism NA 0.146 NA 0 0.125 Q2TB90 T124I Polymorphism 0.588 0.372 0.15 28 0.509 Q2TBA0 N345S Polymorphism 0.087 0.145 0.78 18 0.104 Q2TBF2 T266I Polymorphism NA 0.068 0.03 24 0.130 Q2UY09 A189G Polymorphism 0.873 0.747 0.87 1 0.788 Q2UY09 I239V Polymorphism 0.556 0.086 0.52 8 0.149 Q2UY09 T327S Polymorphism 0.601 0.514 0.75 -21 0.266 Q2V2M9 R475W Polymorphism 0.751 0.683 0.01 43 0.792 Q2VPA4 I139V Polymorphism 0.145 0.288 0.31 2 0.160 Q2VPA4 L491P Polymorphism 0.201 0.242 0.24 17 0.242 Q2VPA4 N402D Polymorphism 0.208 0.342 0.65 31 0.201 Q2VPK5 M253V Polymorphism 0.152 0.063 0.98 -22 0.012 Q2VWP7 T236A Polymorphism 0.112 0.167 0.72 19 0.156 Q2VWP7 I1062L Polymorphism 0.102 0.063 0.89 -2 0.027 Q2VY69 K546E Polymorphism 0.415 0.334 0.02 51 0.705 Q2WEN9 V31F Polymorphism NA 0.394 NA 41 0.085 Q2WGJ6 C504Y Polymorphism 0.640 0.411 0.01 52 0.684 Q2WGJ6 N352Y Polymorphism 0.108 0.537 0.06 6 0.551 Q2WGN9 L273P Polymorphism 0.693 0.540 0.10 25 0.737 Q2Y0W8 D312A Polymorphism 0.425 0.457 0.20 9 0.452 Q30134 G115V Polymorphism 0.232 0.449 0.56 14 0.347 Q30154 K41T Polymorphism 0.565 0.816 0.57 31 0.611 Q30154 M20T Polymorphism 0.221 0.224 0.52 -35 0.254 Q30154 N62H Polymorphism 0.848 0.734 0.00 56 0.925 Q30154 G154A Polymorphism 0.296 0.557 1.00 -24 0.418 Q30167 V236M Polymorphism 0.774 0.513 0.03 43 0.802 Q30201 R6S Disease 0.081 0.413 0.06 -40 0.176 Q30201 G43D Disease 0.718 0.914 0.05 47 0.810 Q30201 G93R Disease 0.360 0.898 0.26 33 0.694 Q30201 R66C Disease 0.349 0.603 0.05 46 0.721 Q30201 S65C Disease 0.742 0.366 0.00 38 0.661 Q30201 V59M Polymorphism 0.303 0.500 0.00 8 0.447 Q30201 A176V Disease 0.626 0.608 0.18 -14 0.540 Q30201 C282Y Disease 0.976 0.888 0.00 69 0.947 Q30201 I105T Disease 0.403 0.430 0.01 35 0.456 Q30201 Q127H Disease 0.109 0.367 0.57 -4 0.129 Q30201 Q283P Disease 0.478 0.644 0.02 31 0.763 Q30201 R224G Disease 0.770 0.912 0.08 50 0.909 Q30201 R330M Disease 0.363 0.652 0.11 -7 0.488 Q30201 T217I Polymorphism 0.344 0.218 0.22 -13 0.330 Q30201 V295A Disease 0.239 0.229 0.37 18 0.240 Q31610 M4T Polymorphism 0.121 0.866 0.29 -7 0.232 Q31610 V9L Polymorphism 0.206 0.168 1.00 -76 0.105 Q31610 A65T Polymorphism 0.254 0.324 0.09 -22 0.353 Q31610 D98Y Polymorphism 0.197 0.187 0.95 0 0.155 Q31610 N87D Polymorphism 0.328 0.398 0.23 19 0.552 Q31610 N87K Polymorphism 0.266 0.677 0.14 25 0.676 Q31610 T97A Polymorphism 0.412 0.151 0.20 -10 0.239 Q31610 V36M Polymorphism 0.403 0.624 0.24 14 0.491 Q31610 E187A Polymorphism 0.367 0.362 0.75 26 0.387 Q31610 E187G Polymorphism 0.577 0.390 0.44 33 0.627 Q31610 E187V Polymorphism 0.511 0.356 0.64 33 0.607 Q31610 H137Y Polymorphism 0.504 0.160 1.00 3 0.099 Q31610 S101N Polymorphism 0.295 0.142 1.00 -29 0.141 Q31610 Y195H Polymorphism 0.709 0.818 0.06 41 0.746 Q31612 M4T Polymorphism 0.121 0.874 0.30 13 0.232 Q31612 N87D Polymorphism 0.328 0.396 0.25 34 0.576 Q31612 R155S Polymorphism 0.255 0.363 0.77 4 0.317 Q32M92 A17T Polymorphism NA 0.066 NA 4 0.047 Q32MK0 S70T Polymorphism NA 0.080 0.00 37 0.181 Q32MK0 V180L Polymorphism NA 0.104 0.00 32 0.154 Q32MQ0 M235V Polymorphism 0.182 0.068 0.43 -10 0.032 Q32MQ0 P288L Polymorphism 0.103 0.268 0.04 10 0.232 Q32MQ0 Q392R Polymorphism 0.215 0.069 0.66 36 0.043 Q32MZ4 E609K Polymorphism NA 0.087 0.16 42 0.080 Q32MZ4 Q275R Polymorphism 0.397 0.080 0.53 10 0.072 Q32P28 M549I Polymorphism 0.132 0.047 0.40 -24 0.067 Q32P28 P506R Polymorphism 0.887 0.717 0.01 47 0.889 Q32P28 Q644K Polymorphism 0.086 0.048 0.91 39 0.063 Q32P41 E294A Polymorphism 0.392 0.312 0.19 -8 0.277 Q32P41 S217P Polymorphism 0.526 0.384 1.00 -60 0.185 Q32P44 Q620K Polymorphism 0.487 0.182 1.00 21 0.263 Q32P51 N215D Polymorphism 0.133 0.340 0.64 34 0.271 Q33E94 S698A Polymorphism 0.176 0.077 0.00 45 0.124 Q3B820 E273K Polymorphism 0.235 0.088 0.00 21 0.189 Q3B820 I107M Polymorphism 0.220 0.067 0.10 -1 0.082 Q3B820 I236V Polymorphism 0.253 0.410 0.00 12 0.286 Q3BBV0 A510T Polymorphism 0.144 0.100 1.00 -13 0.091 Q3BBV0 C591G Polymorphism 0.119 0.145 0.63 -24 0.073 Q3BBV0 H712D Polymorphism 0.627 0.128 0.53 0 0.050 Q3BBV0 Q734P Polymorphism 0.399 0.462 0.06 38 0.558 Q3KNS1 A224G Polymorphism 0.337 0.266 0.27 -6 0.340 Q3KNS1 L152P Polymorphism NA 0.889 0.02 61 0.917 Q3KNS1 M521T Polymorphism 0.238 0.677 0.03 -11 0.417 Q3KNS1 R372K Polymorphism 0.318 0.494 1.00 37 0.484 Q3KNS1 T126A Polymorphism NA 0.137 0.55 -22 0.085 Q3KNW5 S6F Polymorphism NA 0.192 0.03 24 0.349 Q3KNW5 I114V Polymorphism 0.428 0.105 0.45 -21 0.197 Q3KQU3 R104W Polymorphism NA 0.138 0.01 31 0.170 Q3L8U1 D2312E Polymorphism 0.254 0.072 1.00 -52 0.068 Q3LFD5 N325S Polymorphism NA 0.741 0.87 16 0.442 Q3LFD5 Y130C Polymorphism 0.118 0.629 0.10 10 0.238 Q3LHN2 G32C Polymorphism NA 0.379 NA 35 0.160 Q3LI54 A61T Polymorphism NA 0.363 NA 19 0.221 Q3LI61 V17G Polymorphism NA 0.414 NA 34 0.206 Q3LI61 Y13C Polymorphism NA 0.452 NA 32 0.182 Q3LI67 Y51S Polymorphism NA 0.231 NA 49 0.058 Q3LI73 Y48C Polymorphism NA 0.293 NA 41 0.060 Q3LI76 L43M Polymorphism 0.562 0.500 0.13 53 0.761 Q3LIE5 L92R Polymorphism NA 0.364 0.80 -19 0.161 Q3LIE5 E337G Polymorphism NA 0.077 0.00 24 0.178 Q3MHD2 P77R Polymorphism 0.172 0.328 0.06 7 0.283 Q3MIN7 R615C Polymorphism 0.146 0.394 0.16 46 0.272 Q3MIV0 Y29C Polymorphism NA 0.515 NA 36 0.335 Q3MIW9 E419K Polymorphism 0.061 0.181 0.47 16 0.079 Q3MIW9 G337R Polymorphism NA 0.102 0.45 20 0.030 Q3MIX3 R17S Polymorphism NA 0.057 0.36 26 0.033 Q3MJ13 L819F Polymorphism NA 0.308 0.00 44 0.540 Q3MJ13 Q479H Polymorphism 0.349 0.266 0.09 33 0.399 Q3SXY8 R79Q Disease 0.724 0.908 0.02 56 0.673 Q3SXY8 R200C Disease NA 0.682 0.00 48 0.753 Q3SXY8 T348S Polymorphism NA 0.195 NA 22 0.149 Q3SXZ3 R413H Polymorphism 0.942 0.300 1.00 -33 0.013 Q3SY00 R305P Polymorphism NA 0.127 0.23 19 0.018 Q3SY00 S292N Polymorphism NA 0.035 1.00 -26 0.023 Q3SY00 V521M Polymorphism NA 0.041 0.26 -12 0.023 Q3SY05 V98A Polymorphism NA 0.109 NA 41 0.053 Q3SY56 V156I Polymorphism 0.147 0.114 0.39 25 0.202 Q3SY77 Y74N Polymorphism 0.838 0.562 0.01 35 0.801 Q3SY84 E122K Polymorphism 0.396 0.762 0.42 36 0.677 Q3SY84 I355F Polymorphism 0.919 0.620 0.00 29 0.804 Q3SY84 R523Q Polymorphism NA 0.305 0.00 49 0.623 Q3SY84 V107I Polymorphism 0.284 0.420 0.47 -16 0.303 Q3SYC2 C313Y Polymorphism 0.198 0.427 0.78 -4 0.333 Q3SYC2 P196H Polymorphism 0.646 0.876 0.00 24 0.768 Q3SYG4 T12A Polymorphism NA 0.299 NA 11 0.254 Q3SYG4 G141R Disease 0.896 0.937 NA 74 0.945 Q3SYG4 R521Q Polymorphism 0.115 0.483 NA 41 0.273 Q3T8J9 T416A Polymorphism 0.048 0.059 1.00 -27 0.068 Q3T8J9 M1418V Polymorphism 0.125 0.046 0.16 2 0.075 Q3T8J9 Q1539E Polymorphism 0.085 0.177 0.06 22 0.139 Q3T8J9 S1197P Polymorphism 0.062 0.049 1.00 -3 0.025 Q3T906 K4Q Disease NA 0.240 0.00 46 0.423 Q3T906 A662G Polymorphism NA 0.095 0.37 17 0.081 Q3T906 D407A Disease NA 0.943 0.00 63 0.934 Q3T906 I348L Polymorphism NA 0.654 0.07 24 0.491 Q3T906 K1236M Disease NA 0.118 0.00 15 0.176 Q3V5L5 V70I Polymorphism 0.101 0.122 0.45 20 0.081 Q3YBM2 G40E Polymorphism 0.218 0.355 0.32 56 0.605 Q3YBM2 R180W Polymorphism 0.896 0.385 0.02 53 0.594 Q3ZCT8 Q22K Polymorphism NA 0.825 0.93 5 0.470 Q3ZCV2 G126C Polymorphism NA 0.563 NA 58 0.732 Q3ZCV2 Y205H Polymorphism NA 0.077 NA -17 0.010 Q3ZCX4 M437T Polymorphism 0.129 0.609 0.04 36 0.457 Q3ZCX4 Q642R Polymorphism NA 0.341 0.01 19 0.426 Q401N2 A152T Polymorphism 0.247 0.072 0.53 -14 0.079 Q460N3 R315K Polymorphism NA 0.100 0.97 -18 0.073 Q494R4 R101H Polymorphism NA 0.022 0.16 -5 0.041 Q494X3 H233Y Polymorphism 0.939 0.428 0.02 73 0.906 Q495C1 V263I Polymorphism NA 0.177 NA 18 0.056 Q495D7 I84V Polymorphism NA 0.107 NA 27 0.053 Q495M3 A445V Polymorphism 0.675 0.559 0.71 -37 0.370 Q495M9 L48P Disease 0.687 0.435 0.01 48 0.653 Q495N2 K167E Polymorphism NA 0.350 1.00 -23 0.138 Q495N2 S421F Polymorphism 0.926 0.752 0.08 24 0.835 Q495T6 M518T Polymorphism NA 0.377 0.65 -32 0.171 Q495Z4 S32R Polymorphism NA 0.091 0.52 27 0.049 Q496F6 K19T Polymorphism NA 0.078 0.46 -11 0.098 Q496J9 D543N Polymorphism NA 0.206 0.91 53 0.113 Q496J9 T482S Polymorphism NA 0.500 0.13 16 0.461 Q499Z3 R144T Polymorphism NA 0.187 NA 52 0.259 Q49A92 A426T Polymorphism NA 0.035 NA 0 0.033 Q49AG3 A17V Polymorphism NA 0.276 1.00 -8 0.064 Q49AG3 P77S Polymorphism NA 0.113 0.00 -29 0.149 Q49AG3 Q47R Polymorphism NA 0.173 0.00 16 0.025 Q49AG3 I480V Polymorphism 0.079 0.547 0.22 10 0.235 Q49AJ0 D846N Polymorphism 0.337 0.326 NA 40 0.389 Q49AM1 A31V Polymorphism 0.094 0.070 0.67 25 0.033 Q49AM1 L14V Polymorphism 0.300 0.078 0.00 39 0.134 Q49AM3 T205P Polymorphism NA 0.098 0.00 54 0.150 Q49AR2 D405E Polymorphism 0.228 0.288 0.52 0 0.218 Q49AR2 T235P Polymorphism 0.427 0.100 0.07 48 0.108 Q49MG5 N601D Polymorphism NA 0.024 0.56 -7 0.025 Q49MG5 R177W Polymorphism 0.502 0.124 NA 27 0.112 Q4AC94 G1831W Polymorphism 0.814 0.054 0.01 30 0.305 Q4AC94 R1832G Polymorphism 0.547 0.150 0.00 36 0.210 Q4AC94 S1663N Polymorphism 0.460 0.214 0.09 32 0.253 Q4G0A6 M655V Polymorphism 0.200 0.083 1.00 -2 0.076 Q4G0A6 R324K Polymorphism NA 0.077 0.94 23 0.027 Q4G0A6 S262L Polymorphism NA 0.109 0.07 0 0.054 Q4G0N8 I158V Polymorphism NA 0.146 0.17 -21 0.218 Q4G0N8 I286V Polymorphism NA 0.041 0.47 -5 0.088 Q4G0N8 Q732K Polymorphism NA 0.157 0.02 41 0.144 Q4G0N8 T424A Polymorphism NA 0.264 0.73 -10 0.348 Q4G0N8 T705I Polymorphism 0.156 0.094 0.27 -6 0.085 Q4G0P3 N724D Polymorphism 0.045 0.561 0.00 72 0.336 Q4G0P3 R451P Polymorphism 0.541 0.725 0.00 26 0.646 Q4G0P3 T584N Polymorphism 0.461 0.733 0.00 3 0.566 Q4G0P3 I1077V Polymorphism 0.265 0.094 NA 6 0.131 Q4G0P3 V1228L Polymorphism NA 0.043 NA -36 0.046 Q4G0S4 T359M Polymorphism NA 0.091 0.03 -9 0.214 Q4G0S7 R251H Polymorphism NA 0.269 NA 22 0.194 Q4G112 S473N Polymorphism NA 0.080 NA 38 0.076 Q4G176 A17P Polymorphism NA 0.351 0.05 37 0.252 Q4KMG0 K66R Polymorphism 0.178 0.462 0.23 -4 0.174 Q4KMG0 P351A Polymorphism 0.197 0.442 0.03 19 0.281 Q4KMQ2 A128T Polymorphism NA 0.751 0.03 -4 0.577 Q4KMZ1 C217Y Polymorphism NA 0.386 NA 26 0.286 Q4L180 A884P Polymorphism 0.358 0.290 0.24 15 0.141 Q4L180 R168H Polymorphism 0.089 0.041 0.84 -30 0.034 Q4L235 A747V Polymorphism NA 0.067 0.07 3 0.086 Q4L235 K368R Polymorphism NA 0.198 0.53 -14 0.154 Q4L235 T865A Polymorphism NA 0.067 0.22 15 0.102 Q4L235 V774I Polymorphism NA 0.158 0.74 35 0.146 Q4LDE5 G428S Polymorphism NA 0.324 0.28 31 0.374 Q4LDE5 K899R Polymorphism NA 0.064 0.97 48 0.046 Q4LDE5 L1330M Polymorphism NA 0.207 0.11 9 0.316 Q4LDR2 E17V Polymorphism NA 0.051 0.05 28 0.020 Q4LDR2 M23I Polymorphism NA 0.086 0.08 33 0.045 Q4LEZ3 G96R Polymorphism NA 0.019 NA -12 0.017 Q4U2R6 M102I Polymorphism 0.372 0.192 0.24 34 0.173 Q4U2R8 L7P Polymorphism NA 0.920 0.00 56 0.919 Q4U2R8 R50H Polymorphism NA 0.354 0.13 2 0.356 Q4VC05 N120T Polymorphism 0.225 0.078 0.68 -34 0.062 Q4VNC0 E133Q Polymorphism 0.100 0.242 0.59 -18 0.219 Q4VNC0 G739S Polymorphism 0.147 0.363 0.88 -33 0.236 Q4VNC0 K1204Q Polymorphism NA 0.048 NA 2 0.053 Q4VNC0 V1131A Polymorphism NA 0.452 0.56 -37 0.270 Q4VNC1 E646D Polymorphism 0.235 0.157 0.58 2 0.255 Q4VNC1 I181M Polymorphism 0.421 0.123 0.02 23 0.311 Q4VNC1 V353A Polymorphism 0.446 0.708 0.01 44 0.643 Q4VXU2 S212A Polymorphism 0.178 0.516 0.64 -18 0.195 Q4VXU2 S492G Polymorphism NA 0.149 0.41 -10 0.159 Q4W5G0 H475R Polymorphism NA 0.070 0.49 18 0.082 Q4ZG55 V346M Polymorphism NA 0.067 0.00 6 0.139 Q4ZG55 Y1463C Polymorphism NA 0.821 0.00 43 0.781 Q4ZHG4 T438A Polymorphism NA 0.342 0.29 11 0.070 Q4ZHG4 D1180E Polymorphism NA 0.039 0.21 7 0.028 Q4ZHG4 Q1003E Polymorphism NA 0.042 0.20 21 0.027 Q502W6 I1103M Polymorphism NA 0.384 NA -23 0.459 Q502W6 T1277I Polymorphism NA 0.133 NA 35 0.081 Q504Q3 S32N Polymorphism 0.094 0.198 0.00 20 0.172 Q504Y3 L202Q Polymorphism NA 0.095 0.01 -21 0.043 Q52LW3 G1255D Polymorphism NA 0.044 1.00 -18 0.005 Q52M58 R3W Polymorphism NA 0.297 NA 8 0.075 Q52M58 V33A Polymorphism NA 0.069 NA 30 0.049 Q52M62 T18A Polymorphism NA 0.078 NA 25 0.048 Q52M62 T18M Polymorphism NA 0.104 NA 46 0.056 Q52M62 P157S Polymorphism NA 0.113 NA 3 0.053 Q52M62 S126P Polymorphism NA 0.024 NA 10 0.036 Q52M93 V467I Polymorphism 0.331 0.279 0.14 -1 0.349 Q52WX2 N250T Polymorphism 0.233 0.117 0.75 -24 0.127 Q537H7 I8T Polymorphism NA 0.088 NA 1 0.028 Q53EL6 S48Y Polymorphism NA 0.214 0.01 36 0.221 Q53EL9 A330V Polymorphism NA 0.375 0.20 -30 0.180 Q53EL9 M806T Polymorphism 0.150 0.291 0.10 6 0.142 Q53EL9 T546A Polymorphism 0.142 0.236 0.91 5 0.236 Q53EL9 V592A Polymorphism 0.380 0.147 1.00 -4 0.134 Q53EL9 Y736N Polymorphism 0.902 0.296 0.01 46 0.684 Q53ET0 M147V Polymorphism 0.157 0.041 0.30 18 0.059 Q53ET0 R379C Polymorphism 0.083 0.103 0.12 38 0.076 Q53EV4 N65H Polymorphism NA 0.199 0.14 50 0.390 Q53EV4 V317E Polymorphism 0.230 0.134 0.61 -35 0.083 Q53EZ4 C236R Polymorphism NA 0.235 0.36 31 0.127 Q53F39 A268P Polymorphism 0.206 0.128 0.32 -32 0.101 Q53F39 V197M Polymorphism 0.240 0.251 0.48 -22 0.213 Q53FA7 E223K Polymorphism 0.201 0.465 0.91 -5 0.316 Q53FE4 E91K Polymorphism NA 0.194 0.40 25 0.155 Q53FE4 G64E Polymorphism NA 0.315 0.00 39 0.185 Q53FZ2 P308T Polymorphism 0.472 0.522 0.50 14 0.456 Q53G44 H73R Polymorphism NA 0.053 0.47 18 0.071 Q53G44 A104T Polymorphism NA 0.044 0.83 -30 0.067 Q53G44 M390I Polymorphism NA 0.084 0.64 8 0.124 Q53G59 P72L Polymorphism 0.307 0.354 0.29 -12 0.318 Q53GD3 D123V Polymorphism 0.325 0.266 0.17 3 0.205 Q53GD3 G128E Polymorphism 0.074 0.133 1.00 44 0.108 Q53GD3 R493C Polymorphism 0.960 0.968 0.03 41 0.924 Q53GI3 T325M Polymorphism 0.514 0.404 0.12 31 0.652 Q53GL0 P21A Polymorphism 0.060 0.067 0.93 -29 0.059 Q53GL7 V630A Polymorphism NA 0.151 NA 17 0.007 Q53GS7 G130D Polymorphism 0.183 0.595 0.48 31 0.420 Q53GS7 I684T Disease 0.207 0.732 0.01 41 0.676 Q53GS7 R569H Disease 0.849 0.860 0.00 67 0.938 Q53GS7 V617M Disease 0.527 0.136 0.01 48 0.375 Q53H12 V3M Polymorphism NA 0.051 0.07 7 0.056 Q53H76 R110H Polymorphism 0.663 0.788 0.19 -29 0.586 Q53H96 N150K Polymorphism 0.475 0.200 0.93 -39 0.152 Q53H96 V105M Polymorphism 0.774 0.686 0.01 45 0.806 Q53HC0 A253T Polymorphism NA 0.057 0.07 0 0.035 Q53HC0 R281H Polymorphism NA 0.201 0.38 29 0.117 Q53HV7 R105W Polymorphism 0.844 0.905 0.00 47 0.910 Q53QW1 E168K Polymorphism NA 0.096 0.58 15 0.063 Q53R41 E384Q Polymorphism 0.621 0.059 0.19 25 0.058 Q53R41 M467V Polymorphism 0.373 0.079 1.00 21 0.074 Q53S58 G29A Polymorphism 0.123 0.187 0.90 -40 0.149 Q53SZ7 R222C Polymorphism 0.802 0.366 0.00 37 0.556 Q53T59 G273R Polymorphism NA 0.626 NA 24 0.693 Q53T59 P348R Polymorphism NA 0.164 NA 22 0.145 Q53T59 V260M Polymorphism NA 0.040 NA -29 0.040 Q53T94 E462D Polymorphism NA 0.037 1.00 -51 0.009 Q53T94 R292H Polymorphism NA 0.366 0.05 37 0.520 Q53T94 T487M Polymorphism NA 0.140 0.05 18 0.136 Q53T94 V282I Polymorphism NA 0.031 0.91 -25 0.022 Q53TN4 S266N Polymorphism 0.203 0.048 0.00 22 0.095 Q53TS8 H376Q Polymorphism 0.593 0.056 NA -5 0.044 Q562F6 E343A Polymorphism 0.329 0.043 NA 22 0.063 Q562F6 I496V Polymorphism 0.098 0.061 NA -31 0.031 Q562F6 N660S Polymorphism NA 0.043 NA 17 0.057 Q567U6 P228L Polymorphism 0.332 0.154 0.02 -1 0.162 Q567U6 R213C Polymorphism 0.376 0.214 0.00 24 0.347 Q56NI9 A80V Polymorphism 0.477 0.098 1.00 -13 0.071 Q56NI9 W539G Disease 0.805 0.964 0.00 60 0.951 Q56P03 Q168E Polymorphism 0.119 0.112 NA 9 0.088 Q56P42 Q81R Polymorphism NA 0.018 1.00 -12 0.011 Q56VL3 R44Q Polymorphism 0.518 0.121 0.10 10 0.274 Q580R0 P203L Polymorphism NA 0.260 NA 6 0.050 Q587J8 A201G Polymorphism NA 0.103 NA 3 0.068 Q58DX5 G68S Polymorphism NA 0.068 NA -36 0.022 Q58DX5 I128M Polymorphism NA 0.277 0.20 -18 0.241 Q58DX5 M194T Polymorphism NA 0.140 0.23 18 0.188 Q58EX7 R830H Polymorphism 0.536 0.474 0.02 33 0.712 Q58EX7 T412I Polymorphism 0.134 0.160 0.20 30 0.229 Q58EX7 S1090T Polymorphism NA 0.095 0.54 23 0.098 Q58F21 R6Q Polymorphism NA 0.152 0.37 21 0.135 Q58F21 S2F Polymorphism NA 0.399 0.00 0 0.499 Q58F21 K238N Polymorphism 0.143 0.091 0.26 25 0.214 Q58F21 K336T Polymorphism 0.149 0.352 0.07 -3 0.205 Q58F21 P696L Polymorphism NA 0.118 0.12 -8 0.020 Q58G82 T97M Polymorphism NA 0.032 0.11 0 0.075 Q58WW2 V547A Polymorphism 0.055 0.046 NA 38 0.037 Q5BJE1 A42T Polymorphism NA 0.344 NA 28 0.255 Q5BJE1 D601N Polymorphism NA 0.058 0.31 -2 0.035 Q5BJE1 L600R Polymorphism NA 0.363 0.27 20 0.220 Q5BJF6 T710S Polymorphism 0.067 0.067 0.58 -47 0.022 Q5BJH7 P56S Polymorphism 0.302 0.477 0.37 23 0.456 Q5BKX6 P277L Polymorphism 0.277 0.156 0.03 28 0.214 Q5BVD1 L66P Polymorphism NA 0.764 NA 38 0.770 Q5C9Z4 M723V Polymorphism 0.159 0.161 0.27 34 0.249 Q5C9Z4 V804L Polymorphism 0.174 0.100 0.92 17 0.125 Q5C9Z4 V812M Polymorphism 0.284 0.029 0.29 -50 0.069 Q5D1E8 G547D Polymorphism 0.360 0.148 NA 24 0.129 Q5D862 L41F Polymorphism 0.210 0.041 1.00 19 0.025 Q5D862 C298S Polymorphism NA 0.164 0.77 35 0.103 Q5D862 R107Q Polymorphism NA 0.074 0.54 30 0.068 Q5D862 E1992D Polymorphism NA 0.095 0.70 19 0.170 Q5D862 Q2239H Polymorphism NA 0.277 0.21 14 0.400 Q5DID0 M559T Polymorphism 0.465 0.034 0.00 -9 0.048 Q5DID0 V850I Polymorphism NA 0.018 NA -3 0.066 Q5DID0 D1208N Polymorphism NA 0.089 0.01 0 0.173 Q5DID0 E1115K Polymorphism NA 0.235 0.06 61 0.355 Q5DID0 G1068S Polymorphism NA 0.568 0.13 52 0.734 Q5DID0 N1309H Polymorphism NA 0.067 NA 49 0.094 Q5DID0 S1027N Polymorphism NA 0.236 0.03 47 0.353 Q5DX21 S388N Polymorphism 0.277 0.057 0.85 34 0.059 Q5EBM0 K433R Polymorphism NA 0.064 0.01 -25 0.087 Q5EG05 A56D Polymorphism 0.079 0.449 0.66 -9 0.182 Q5EG05 Q37K Polymorphism 0.089 0.202 0.83 4 0.166 Q5EG05 N167I Polymorphism NA 0.415 NA 30 0.104 Q5FBB7 Q322P Polymorphism NA 0.080 0.33 -27 0.039 Q5FVE4 E626Q Polymorphism 0.192 0.203 1.00 -67 0.089 Q5FVE4 K152R Polymorphism 0.098 0.371 0.52 -40 0.141 Q5FWF4 R546Q Polymorphism 0.182 0.080 0.03 28 0.082 Q5GFL6 A9T Polymorphism NA 0.123 0.13 3 0.114 Q5GFL6 E131G Polymorphism 0.095 0.323 1.00 16 0.061 Q5GH77 F255L Polymorphism NA 0.082 1.00 -21 0.014 Q5GH77 P232L Polymorphism NA 0.780 0.65 30 0.742 Q5H8A4 S55Y Polymorphism NA 0.479 0.07 -33 0.407 Q5H8A4 F932S Polymorphism 0.075 0.202 0.07 0 0.038 Q5H8A4 I881T Polymorphism 0.237 0.122 0.07 24 0.229 Q5H8A4 V699I Polymorphism 0.130 0.088 0.59 -27 0.077 Q5H8A4 V731I Polymorphism 0.161 0.146 0.60 11 0.142 Q5H8C1 I499V Polymorphism NA 0.140 1.00 17 0.143 Q5H8C1 L863V Polymorphism NA 0.158 0.65 -38 0.126 Q5H8C1 S803Y Polymorphism NA 0.419 0.05 50 0.683 Q5H8C1 V439L Polymorphism NA 0.397 0.06 14 0.364 Q5H8C1 N1576I Polymorphism NA 0.315 0.19 27 0.392 Q5H8C1 V1502M Polymorphism NA 0.575 0.08 -6 0.491 Q5H8C1 V2174G Polymorphism 0.603 0.334 NA 53 0.543 Q5H9K5 R214K Polymorphism 0.132 0.032 0.82 18 0.050 Q5H9L4 E61K Polymorphism NA 0.059 NA 0 0.048 Q5H9L4 L34P Polymorphism NA 0.072 NA -38 0.040 Q5H9L4 R458H Polymorphism 0.247 0.031 0.04 -12 0.058 Q5H9M0 G95D Polymorphism NA 0.097 1.00 -37 0.025 Q5H9T9 L380P Polymorphism NA 0.090 0.13 -16 0.027 Q5H9T9 P119S Polymorphism NA 0.053 0.44 -29 0.039 Q5H9U9 A583T Polymorphism NA 0.047 0.01 -20 0.085 Q5H9U9 N355K Polymorphism NA 0.082 0.34 44 0.096 Q5H9U9 S1080C Polymorphism NA 0.291 0.00 -10 0.299 Q5HY98 C95Y Polymorphism NA 0.805 1.00 -6 0.176 Q5HYA8 G545E Disease 0.827 0.266 NA 11 0.546 Q5HYA8 Q376P Disease 0.584 0.559 NA 27 0.722 Q5HYA8 Y513C Disease 0.804 0.841 NA 37 0.690 Q5HYI7 S238R Polymorphism 0.268 0.583 0.65 -3 0.290 Q5HYK9 P134L Polymorphism 0.066 0.283 0.39 20 0.233 Q5I0G3 E510D Polymorphism NA 0.193 NA -13 0.057 Q5IJ48 T90N Polymorphism 0.054 0.256 0.47 -45 0.113 Q5IJ48 H746Q Polymorphism NA 0.136 0.21 41 0.242 Q5J8X5 P58L Polymorphism NA 0.264 0.12 21 0.176 Q5JPB2 G845R Polymorphism NA 0.152 NA 18 0.135 Q5JPE7 D490N Polymorphism 0.053 0.267 NA -13 0.170 Q5JPE7 N726K Polymorphism 0.064 0.068 NA 21 0.058 Q5JPH6 S457G Polymorphism 0.179 0.208 0.38 -18 0.167 Q5JPI9 R67Q Polymorphism 0.249 0.441 0.12 27 0.403 Q5JQC9 A673G Polymorphism 0.222 0.030 0.41 -41 0.022 Q5JQC9 H233R Polymorphism 0.097 0.029 1.00 -31 0.014 Q5JQD4 T28I Polymorphism 0.208 0.109 0.00 0 0.173 Q5JQS5 D300G Polymorphism 0.725 0.780 0.01 41 0.878 Q5JQS5 T293I Polymorphism 0.805 0.076 1.00 -61 0.121 Q5JQS5 V198M Polymorphism 0.381 0.528 0.23 8 0.402 Q5JR12 L213F Polymorphism NA 0.113 0.29 33 0.209 Q5JR59 L1071Q Polymorphism NA 0.798 0.00 44 0.766 Q5JRA6 E881G Polymorphism NA 0.108 0.01 28 0.186 Q5JRA6 G1659C Polymorphism 0.187 0.536 0.01 44 0.696 Q5JRA6 K1723E Polymorphism 0.130 0.146 0.13 49 0.195 Q5JRC9 V232E Polymorphism NA 0.327 0.40 48 0.507 Q5JRM2 P233L Polymorphism NA 0.030 NA 16 0.035 Q5JRS4 Q235R Polymorphism 0.593 0.229 1.00 9 0.334 Q5JRX3 A554D Polymorphism 0.376 0.618 0.03 29 0.522 Q5JRX3 F169S Polymorphism 0.303 0.711 0.34 24 0.493 Q5JRX3 I952M Polymorphism 0.617 0.378 0.03 -25 0.535 Q5JRX3 P969L Polymorphism 0.666 0.928 0.40 18 0.846 Q5JRX3 R805Q Polymorphism 0.437 0.371 0.45 0 0.293 Q5JRX3 V328I Polymorphism 0.286 0.121 0.54 -26 0.128 Q5JRX3 V397A Polymorphism 0.323 0.196 0.83 -31 0.139 Q5JRX3 V621I Polymorphism 0.345 0.194 0.31 -11 0.271 Q5JRX3 V963I Polymorphism 0.284 0.079 0.28 -10 0.183 Q5JRX3 R1037Q Polymorphism 0.122 0.339 0.05 -10 0.210 Q5JST6 E208K Polymorphism 0.178 0.098 0.93 -25 0.082 Q5JST6 E507Q Polymorphism 0.433 0.256 0.04 17 0.372 Q5JST6 S430Y Polymorphism NA 0.116 0.14 8 0.187 Q5JT82 Q80H Polymorphism NA 0.173 0.06 55 0.185 Q5JTC6 A278S Polymorphism NA 0.103 0.36 -29 0.070 Q5JTH9 G1145S Polymorphism 0.138 0.441 0.79 -21 0.225 Q5JTN6 H172R Polymorphism 0.121 0.248 1.00 -17 0.018 Q5JTV8 M146T Polymorphism NA 0.027 1.00 14 0.035 Q5JTV8 Q293H Polymorphism NA 0.072 0.00 12 0.139 Q5JTZ9 I339V Polymorphism 0.411 0.013 0.40 -64 0.190 Q5JU00 H53R Polymorphism NA 0.089 0.28 7 0.065 Q5JU67 Y483S Polymorphism NA 0.337 0.39 -4 0.163 Q5JU69 K203E Polymorphism 0.190 0.081 1.00 -25 0.046 Q5JVG8 T189P Polymorphism 0.870 0.338 0.23 30 0.697 Q5JVL4 P77T Disease 0.183 0.170 0.01 3 0.226 Q5JVL4 D210N Disease 0.684 0.815 0.00 68 0.766 Q5JVL4 D253Y Disease 0.599 0.516 0.01 -13 0.690 Q5JVL4 F229L Disease 0.191 0.177 0.80 1 0.195 Q5JVL4 I619L Polymorphism 0.263 0.079 1.00 -5 0.086 Q5JVL4 M448T Polymorphism 0.234 0.192 1.00 8 0.163 Q5JVL4 R182H Polymorphism 0.159 0.173 0.01 -45 0.165 Q5JVL4 R221H Disease 0.314 0.552 0.00 8 0.502 Q5JVL4 R285I Polymorphism 0.700 0.891 0.00 66 0.767 Q5JVL4 R294H Polymorphism 0.832 0.964 0.00 71 0.951 Q5JVL4 R353W Disease 0.754 0.210 0.01 17 0.343 Q5JVX7 E85G Polymorphism NA 0.064 NA 24 0.059 Q5JWF2 A436D Disease NA 0.227 0.04 20 0.084 Q5JWF2 P459R Disease NA 0.314 0.02 35 0.170 Q5JWF2 R1023L Polymorphism NA 0.600 0.14 12 0.572 Q5JWR5 R596Q Polymorphism 0.411 0.188 0.07 43 0.359 Q5JWR5 Q1781L Polymorphism 0.515 0.278 0.28 3 0.495 Q5JX69 E129A Polymorphism NA 0.061 NA 2 0.077 Q5JX71 L95F Polymorphism NA 0.022 NA 9 0.060 Q5JX71 R146K Polymorphism NA 0.023 NA 23 0.065 Q5JXA9 E215A Polymorphism 0.148 0.249 0.71 5 0.049 Q5JXA9 G153E Polymorphism 0.196 0.586 0.20 66 0.467 Q5JXC2 K99N Polymorphism NA 0.055 NA 19 0.062 Q5JXC2 P381S Polymorphism NA 0.161 NA 46 0.103 Q5JXM2 L281F Polymorphism NA 0.122 0.00 -25 0.170 Q5JYT7 A633V Polymorphism 0.097 0.198 0.36 15 0.073 Q5JYT7 E940K Polymorphism 0.048 0.081 0.28 -13 0.026 Q5JYT7 K339N Polymorphism 0.104 0.111 0.51 17 0.073 Q5JZY3 A956T Polymorphism 0.297 0.415 0.18 29 0.371 Q5JZY3 F281I Polymorphism 0.224 0.240 0.28 33 0.159 Q5JZY3 G749E Polymorphism 0.513 0.935 0.11 23 0.590 Q5JZY3 L629P Polymorphism NA 0.443 1.00 24 0.199 Q5JZY3 L630P Polymorphism NA 0.723 0.19 -29 0.589 Q5JZY3 R807Q Polymorphism 0.365 0.500 0.01 45 0.572 Q5JZY3 T220K Polymorphism 0.254 0.386 0.31 -54 0.331 Q5JZY3 V103L Polymorphism 0.131 0.588 0.03 4 0.440 Q5JZY3 V645I Polymorphism 0.147 0.051 1.00 12 0.060 Q5K4L6 G110A Polymorphism 0.145 0.043 0.09 -15 0.034 Q5K4L6 R439H Polymorphism 0.653 0.586 0.05 50 0.790 Q5K651 K1495E Disease NA 0.333 0.00 23 0.494 Q5KU26 G606S Polymorphism NA 0.320 0.23 35 0.331 Q5KU26 I487V Polymorphism 0.124 0.353 0.35 5 0.141 Q5M775 M293L Polymorphism 0.115 0.099 1.00 -11 0.021 Q5M775 S274R Polymorphism 0.248 0.263 0.24 39 0.357 Q5M9Q1 Y96C Polymorphism 0.393 0.613 NA 27 0.684 Q5M9Q1 T152N Polymorphism 0.370 0.262 0.00 6 0.220 Q5MAI5 R53H Polymorphism 0.675 0.251 0.02 -1 0.561 Q5MAI5 S38P Polymorphism 0.459 0.386 0.14 28 0.566 Q5MAI5 F228C Polymorphism NA 0.768 0.14 13 0.700 Q5MAI5 H118Y Polymorphism 0.998 0.881 0.00 69 0.952 Q5MAI5 R307C Polymorphism NA 0.308 0.04 34 0.501 Q5MAI5 S288Y Polymorphism NA 0.473 0.01 27 0.669 Q5MIZ7 S293T Polymorphism 0.523 0.725 0.10 23 0.532 Q5MJ08 K48N Polymorphism 0.388 0.116 0.02 26 0.143 Q5MJ09 V89I Polymorphism 0.071 0.053 0.31 5 0.035 Q5MJ10 T8I Polymorphism 0.118 0.131 0.13 26 0.092 Q5MY95 L62P Polymorphism 0.542 0.816 1.00 -29 0.536 Q5NE16 S123G Polymorphism NA 0.164 0.03 43 0.139 Q5PT55 I287T Polymorphism 0.762 0.598 0.08 -3 0.778 Q5QGS0 I1112T Polymorphism 0.327 0.088 0.04 39 0.068 Q5QJ38 A193G Polymorphism NA 0.102 0.03 18 0.099 Q5QJE6 Y676F Polymorphism 0.209 0.871 0.00 42 0.559 Q5QJU3 A134V Polymorphism 0.104 0.149 1.00 -36 0.062 Q5R3I4 F243L Polymorphism NA 0.074 0.68 -22 0.097 Q5R3K3 E293K Polymorphism NA 0.260 0.00 46 0.266 Q5RHP9 H691R Polymorphism 0.115 0.096 0.24 44 0.064 Q5RHP9 I636V Polymorphism 0.073 0.045 0.66 0 0.036 Q5RHP9 P264A Polymorphism 0.047 0.254 NA 32 0.276 Q5RHP9 R555H Polymorphism 0.306 0.057 0.03 10 0.051 Q5RHP9 V1528M Polymorphism NA 0.119 NA -9 0.013 Q5S007 C228S Polymorphism NA 0.255 NA -5 0.122 Q5S007 D944Y Polymorphism NA 0.154 0.00 38 0.167 Q5S007 I723V Polymorphism NA 0.106 NA 0 0.106 Q5S007 L119P Polymorphism NA 0.600 NA 50 0.725 Q5S007 Q930R Disease NA 0.077 0.00 47 0.109 Q5S007 R793M Disease NA 0.177 NA 35 0.190 Q5S007 D1375E Polymorphism NA 0.316 0.00 43 0.318 Q5S007 E2395K Polymorphism NA 0.177 NA 18 0.151 Q5S007 G2019S Disease NA 0.833 0.00 65 0.904 Q5S007 G2385R Polymorphism NA 0.094 NA 36 0.080 Q5S007 I1122V Disease NA 0.199 0.06 41 0.229 Q5S007 I1371V Disease NA 0.438 0.00 28 0.333 Q5S007 I2012T Disease NA 0.270 0.07 41 0.218 Q5S007 I2020T Disease NA 0.330 0.00 45 0.318 Q5S007 L1870F Polymorphism NA 0.590 0.01 49 0.588 Q5S007 M1869T Disease NA 0.093 0.00 56 0.204 Q5S007 P1542S Disease NA 0.194 0.00 29 0.259 Q5S007 P2119L Polymorphism NA 0.646 0.00 53 0.723 Q5S007 R1398H Polymorphism NA 0.336 0.00 37 0.239 Q5S007 R1441G Disease NA 0.747 0.00 41 0.790 Q5S007 R1441H Disease NA 0.511 0.00 47 0.600 Q5S007 R1514Q Disease NA 0.116 0.12 -1 0.137 Q5S007 R1941H Disease NA 0.645 0.17 52 0.506 Q5S007 S1096C Disease 0.579 0.386 0.00 39 0.616 Q5S007 S1228T Disease 0.282 0.391 0.03 54 0.461 Q5S007 S1647T Polymorphism NA 0.255 0.00 -34 0.249 Q5S007 T2356I Disease NA 0.101 NA -19 0.075 Q5S007 V1598E Disease NA 0.710 0.00 52 0.837 Q5S007 Y1699C Disease NA 0.699 0.00 58 0.848 Q5SGD2 A262S Polymorphism 0.647 0.568 0.12 20 0.634 Q5SNV9 P453S Polymorphism NA 0.060 NA 22 0.037 Q5SNV9 R800C Polymorphism NA 0.127 NA 5 0.024 Q5SNV9 S848I Polymorphism NA 0.077 NA 26 0.063 Q5SNV9 W955R Polymorphism NA 0.181 NA 14 0.022 Q5SNV9 R1215H Polymorphism NA 0.174 NA 46 0.032 Q5SNV9 R1451G Polymorphism NA 0.205 NA 37 0.071 Q5SQ64 P39S Polymorphism NA 0.200 NA 19 0.169 Q5SQ64 A107T Polymorphism NA 0.160 NA -10 0.026 Q5SQN1 G119R Polymorphism NA 0.402 0.03 35 0.521 Q5SQN1 R381C Polymorphism NA 0.224 0.10 5 0.183 Q5SQN1 V154M Polymorphism NA 0.037 0.10 8 0.065 Q5SQS7 S239L Polymorphism 0.681 0.615 0.01 30 0.711 Q5SR56 V406L Polymorphism NA 0.397 0.24 28 0.351 Q5SRE5 N1587K Polymorphism NA 0.137 NA -15 0.019 Q5SRN2 Y36H Polymorphism NA 0.076 NA 49 0.056 Q5SRN2 A433T Polymorphism NA 0.097 0.27 26 0.052 Q5SRN2 I150F Polymorphism NA 0.214 NA 23 0.168 Q5SRN2 K400Q Polymorphism NA 0.195 0.33 29 0.166 Q5SRN2 L266W Polymorphism NA 0.305 0.04 36 0.224 Q5SRN2 P128L Polymorphism NA 0.170 NA 10 0.021 Q5SRN2 P274S Polymorphism NA 0.081 0.26 -10 0.027 Q5SRN2 S227P Polymorphism NA 0.269 NA 30 0.192 Q5SSG8 A315V Polymorphism NA 0.074 0.39 31 0.060 Q5SSG8 D319E Polymorphism NA 0.070 0.07 16 0.041 Q5SSG8 E161G Polymorphism NA 0.078 0.13 10 0.018 Q5SSG8 S328N Polymorphism NA 0.039 0.13 -14 0.057 Q5SSG8 V285A Polymorphism NA 0.062 0.69 -14 0.018 Q5SSQ6 P30S Polymorphism NA 0.186 NA 8 0.075 Q5SSQ6 P99L Polymorphism NA 0.025 1.00 -26 0.018 Q5ST30 H26Y Polymorphism NA 0.060 NA 28 0.047 Q5ST30 A965T Polymorphism 0.234 0.274 0.26 -53 0.295 Q5ST30 R917Q Polymorphism 0.624 0.886 0.01 54 0.917 Q5SVQ8 D327Y Polymorphism NA 0.488 0.02 46 0.618 Q5SVZ6 V73M Polymorphism NA 0.099 0.21 -46 0.065 Q5SVZ6 E493G Polymorphism 0.391 0.500 0.12 51 0.569 Q5SW24 T541P Polymorphism 0.485 0.083 0.32 -2 0.024 Q5SW96 S202H Disease 0.533 0.147 0.14 37 0.179 Q5SWA1 E363G Polymorphism 0.299 0.073 NA 8 0.042 Q5SWA1 K589E Polymorphism 0.096 0.068 NA -16 0.028 Q5SWA1 N308S Polymorphism 0.065 0.009 NA -16 0.035 Q5SWX8 S251C Polymorphism NA 0.186 0.12 -27 0.205 Q5SXH7 V337I Polymorphism NA 0.085 0.00 8 0.113 Q5SXM1 K144E Polymorphism 0.512 0.304 0.35 14 0.518 Q5SXM2 H799Q Polymorphism NA 0.098 0.03 -13 0.021 Q5SXM2 P1448S Polymorphism NA 0.267 NA 15 0.108 Q5SXM8 S178T Polymorphism NA 0.138 NA -11 0.129 Q5SY16 R10W Polymorphism NA 0.427 NA 62 0.452 Q5SY16 S58A Polymorphism NA 0.033 NA -40 0.008 Q5SY16 W50R Polymorphism NA 0.053 NA 2 0.012 Q5SY16 I420V Polymorphism 0.198 0.084 0.51 -35 0.107 Q5SYB0 T6P Polymorphism NA 0.058 0.32 5 0.049 Q5SYB0 A44T Polymorphism NA 0.080 0.18 -37 0.055 Q5SYB0 Y846D Polymorphism 0.504 0.648 0.10 26 0.702 Q5SYE7 G1585S Polymorphism NA 0.123 0.00 5 0.191 Q5SZB4 R312Q Polymorphism NA 0.436 NA 56 0.173 Q5SZK8 V770M Polymorphism NA 0.144 0.23 12 0.211 Q5SZK8 E1972K Disease NA 0.921 0.14 60 0.916 Q5SZK8 F1070S Polymorphism NA 0.197 0.09 7 0.220 Q5SZK8 I1045S Polymorphism NA 0.520 0.03 -1 0.543 Q5SZK8 M1039K Polymorphism NA 0.428 0.76 29 0.318 Q5SZK8 T2153S Polymorphism NA 0.261 1.00 -17 0.219 Q5SZL2 D166V Polymorphism NA 0.216 0.09 2 0.180 Q5SZL2 Q532H Polymorphism NA 0.069 0.12 10 0.101 Q5T036 L22F Polymorphism NA 0.142 NA 17 0.060 Q5T089 H330Y Polymorphism NA 0.135 NA 46 0.106 Q5T0J7 L171R Polymorphism NA 0.397 NA 44 0.359 Q5T0T0 P92S Polymorphism 0.611 0.597 0.52 33 0.520 Q5T0W9 N410S Polymorphism 0.786 0.067 0.27 2 0.056 Q5T0W9 S435R Polymorphism 0.246 0.090 0.10 32 0.085 Q5T124 A474V Polymorphism NA 0.063 0.00 -3 0.161 Q5T124 L312R Polymorphism NA 0.233 0.76 -14 0.047 Q5T160 D367G Polymorphism 0.637 0.882 0.01 29 0.715 Q5T160 K291R Polymorphism 0.524 0.709 0.01 -40 0.523 Q5T197 T158I Polymorphism 0.603 0.629 0.00 29 0.615 Q5T1C6 L17R Polymorphism NA 0.286 0.31 36 0.128 Q5T1C6 S38C Polymorphism NA 0.111 0.06 23 0.120 Q5T1M5 A106T Polymorphism NA 0.121 0.01 -33 0.090 Q5T1M5 L434F Polymorphism NA 0.119 0.00 42 0.153 Q5T1N1 A104V Polymorphism NA 0.065 NA 23 0.090 Q5T1N1 C654Y Polymorphism NA 0.270 NA 26 0.127 Q5T1N1 E167G Polymorphism NA 0.141 NA 10 0.121 Q5T1N1 L352V Polymorphism NA 0.040 NA -10 0.092 Q5T1N1 N616K Polymorphism NA 0.052 NA -9 0.029 Q5T1R4 V35I Polymorphism NA 0.058 0.27 17 0.049 Q5T1R4 H575R Polymorphism NA 0.032 0.01 -15 0.015 Q5T1R4 T2339A Polymorphism NA 0.036 NA -49 0.017 Q5T1V6 I107V Polymorphism NA 0.092 1.00 -37 0.032 Q5T200 E1429D Polymorphism NA 0.016 0.01 -34 0.035 Q5T230 G73R Polymorphism 0.675 0.406 0.10 33 0.431 Q5T280 A63V Polymorphism NA 0.088 0.20 3 0.103 Q5T280 I369T Polymorphism 0.126 0.056 0.05 -42 0.015 Q5T2D2 V50M Polymorphism 0.430 0.102 0.22 35 0.066 Q5T2D2 S144G Polymorphism NA 0.106 0.29 33 0.070 Q5T2D3 A333T Polymorphism NA 0.093 NA -23 0.085 Q5T2L2 R50H Polymorphism 0.833 0.860 0.05 52 0.723 Q5T2Q4 I288V Polymorphism NA 0.101 1.00 0 0.093 Q5T2Q4 R176Q Polymorphism NA 0.125 0.02 55 0.244 Q5T2R2 D308E Disease 0.990 0.841 0.00 68 0.940 Q5T2T1 K322R Polymorphism 0.170 0.175 1.00 -34 0.096 Q5T3F8 V307M Polymorphism NA 0.131 0.23 15 0.260 Q5T3J3 A438T Polymorphism 0.301 0.084 NA 26 0.071 Q5T3J3 S599P Polymorphism 0.472 0.432 NA -38 0.222 Q5T440 G211S Polymorphism 0.171 0.407 0.64 11 0.224 Q5T442 P90S Disease 0.923 0.910 0.00 41 0.905 Q5T442 M286T Disease 0.399 0.630 0.01 22 0.730 Q5T442 Y272D Disease 0.633 0.670 0.07 49 0.853 Q5T481 P173T Polymorphism NA 0.163 NA 30 0.090 Q5T481 W768S Polymorphism 0.572 0.093 0.06 38 0.032 Q5T4D3 V419I Polymorphism NA 0.461 0.71 16 0.307 Q5T4F4 V82I Polymorphism NA 0.088 0.75 -52 0.019 Q5T4F4 G138V Polymorphism NA 0.035 1.00 0 0.021 Q5T4F4 G191V Disease NA 0.665 0.00 34 0.706 Q5T4F7 G7A Polymorphism NA 0.065 0.00 -67 0.055 Q5T4J0 P316L Polymorphism NA 0.593 0.00 -28 0.525 Q5T4S7 M4867L Polymorphism 0.114 0.027 0.62 14 0.035 Q5T4S7 T1107A Polymorphism 0.113 0.054 0.00 14 0.096 Q5T4S7 V5084M Polymorphism 0.600 0.159 0.00 16 0.287 Q5T4T6 V94I Polymorphism NA 0.027 0.76 -37 0.012 Q5T4T6 P672S Polymorphism 0.059 0.152 0.00 -10 0.196 Q5T4W7 Q19R Polymorphism 0.057 0.067 0.66 6 0.029 Q5T5C0 N436S Polymorphism 0.132 0.131 0.97 -2 0.092 Q5T5J6 I148V Polymorphism 0.129 0.101 NA 16 0.054 Q5T5J6 L638F Polymorphism NA 0.220 NA 26 0.379 Q5T5J6 N821D Polymorphism NA 0.162 NA 42 0.176 Q5T5N4 G271E Polymorphism NA 0.485 NA 8 0.560 Q5T5N4 I256M Polymorphism NA 0.057 NA 43 0.118 Q5T5N4 T301M Polymorphism NA 0.030 NA -18 0.078 Q5T5S1 M38T Polymorphism NA 0.033 0.24 -11 0.045 Q5T5U3 N712S Polymorphism 0.068 0.061 0.60 13 0.066 Q5T5U3 A1726T Polymorphism 0.065 0.054 NA 18 0.069 Q5T5U3 S1949N Polymorphism 0.147 0.094 0.02 33 0.052 Q5T5U3 T1593A Polymorphism 0.193 0.191 0.07 25 0.138 Q5T5U3 V1610A Polymorphism 0.388 0.172 0.01 35 0.237 Q5T5Y3 A476V Polymorphism 0.206 0.131 0.40 -18 0.195 Q5T619 N111K Polymorphism NA 0.060 0.95 39 0.052 Q5T655 Q804H Polymorphism NA 0.088 0.14 31 0.195 Q5T655 S496T Polymorphism NA 0.388 0.60 -20 0.245 Q5T681 E121D Polymorphism 0.089 0.118 NA -40 0.049 Q5T6C5 P495S Polymorphism 0.168 0.096 0.64 -7 0.068 Q5T6F2 A756V Polymorphism 0.185 0.148 1.00 28 0.072 Q5T6F2 M762I Polymorphism 0.082 0.160 0.38 33 0.208 Q5T6F2 N606S Polymorphism NA 0.132 0.71 -7 0.067 Q5T6F2 P429L Polymorphism 0.145 0.388 0.02 10 0.473 Q5T6X5 I144R Polymorphism NA 0.804 0.00 74 0.909 Q5T749 Q14H Polymorphism NA 0.061 NA 15 0.054 Q5T749 V37A Polymorphism NA 0.288 NA 12 0.182 Q5T749 R168H Polymorphism NA 0.109 0.02 -30 0.140 Q5T750 S26T Polymorphism NA 0.056 NA -39 0.019 Q5T753 S59G Polymorphism NA 0.200 NA -3 0.017 Q5T7B8 D50E Polymorphism NA 0.477 NA -13 0.500 Q5T7B8 W218L Polymorphism NA 0.091 0.09 33 0.146 Q5T7B8 T1077K Polymorphism 0.373 0.054 NA 44 0.076 Q5T7N2 R27S Polymorphism NA 0.092 NA 24 0.058 Q5T7N2 K329N Polymorphism NA 0.131 NA -3 0.064 Q5T7N2 P549T Polymorphism 0.483 0.107 0.48 11 0.080 Q5T7N2 T613I Polymorphism 0.365 0.143 0.05 25 0.146 Q5T7N2 V246A Polymorphism NA 0.080 0.14 -33 0.105 Q5T7N3 A987V Polymorphism 0.104 0.043 1.00 25 0.064 Q5T7N3 G701S Polymorphism NA 0.073 0.74 42 0.092 Q5T7N3 T768A Polymorphism NA 0.101 0.81 43 0.138 Q5T7N3 V840A Polymorphism 0.213 0.672 0.16 6 0.416 Q5T7V8 E320K Polymorphism 0.321 0.228 0.00 36 0.195 Q5T8A7 G576S Polymorphism 0.114 0.058 0.69 -19 0.027 Q5T8A7 K206E Polymorphism 0.108 0.053 1.00 -11 0.035 Q5T8A7 M434T Polymorphism 0.086 0.024 0.70 -23 0.017 Q5T8A7 R346K Polymorphism 0.165 0.115 0.85 -22 0.082 Q5T8A7 R520H Polymorphism 0.486 0.090 0.16 -20 0.031 Q5T8R8 L43R Polymorphism NA 0.572 NA 23 0.339 Q5T8R8 R231G Polymorphism NA 0.205 NA 23 0.028 Q5T9A4 V7I Polymorphism 0.078 0.113 1.00 -40 0.029 Q5TA76 R59C Polymorphism NA 0.284 NA 38 0.072 Q5TAH2 A505G Polymorphism NA 0.122 0.19 11 0.242 Q5TAH2 R934S Polymorphism NA 0.118 0.00 43 0.186 Q5TAP6 G85V Polymorphism NA 0.136 0.34 -21 0.130 Q5TAP6 T101A Polymorphism NA 0.124 1.00 -37 0.109 Q5TAX3 D796Y Polymorphism NA 0.120 NA 36 0.119 Q5TB80 C266S Polymorphism NA 0.073 0.07 -10 0.053 Q5TB80 E272Q Polymorphism NA 0.056 0.16 -40 0.042 Q5TB80 E348Q Polymorphism NA 0.263 0.00 2 0.266 Q5TB80 S342C Polymorphism NA 0.250 0.00 10 0.291 Q5TBA9 G1968S Polymorphism NA 0.075 0.66 -32 0.063 Q5TBB1 H86R Disease 0.458 0.190 0.27 39 0.397 Q5TBB1 L60R Disease 0.647 0.728 0.01 46 0.841 Q5TBB1 A177T Disease 0.361 0.293 0.21 10 0.420 Q5TBB1 K162T Disease 0.598 0.330 0.00 54 0.600 Q5TBB1 T163I Disease 0.447 0.450 0.03 -6 0.523 Q5TBB1 V185G Disease 0.676 0.761 0.00 40 0.835 Q5TBB1 Y219H Disease 0.780 0.730 0.00 65 0.917 Q5TBC7 D90N Polymorphism NA 0.060 NA 21 0.029 Q5TC12 S62G Polymorphism 0.325 0.074 0.65 -15 0.021 Q5TCH4 C230S Polymorphism 0.228 0.257 0.56 -26 0.049 Q5TCH4 C231R Polymorphism 0.541 0.316 1.00 -11 0.000 Q5TCH4 G130S Polymorphism 0.361 0.901 0.00 18 0.586 Q5TCH4 K121R Polymorphism 0.110 0.197 0.75 -27 0.155 Q5TCH4 L509F Polymorphism NA 0.632 0.01 48 0.766 Q5TCH4 M491I Polymorphism NA 0.186 0.52 -19 0.150 Q5TCH4 N152Y Polymorphism 0.502 0.228 0.74 -49 0.015 Q5TCH4 R126W Polymorphism 0.326 0.573 1.00 -54 0.293 Q5TCH4 S226N Polymorphism 0.169 0.320 0.50 -40 0.159 Q5TCX8 C784G Polymorphism 0.205 0.159 0.57 -7 0.059 Q5TCX8 D420N Polymorphism 0.290 0.638 0.53 10 0.393 Q5TCX8 P982L Polymorphism NA 0.103 0.21 -11 0.122 Q5TCX8 R977C Polymorphism NA 0.110 0.04 35 0.091 Q5TCX8 S597F Polymorphism 0.787 0.520 0.00 43 0.753 Q5TCX8 T900I Polymorphism NA 0.081 0.18 12 0.093 Q5TCY1 D741E Polymorphism NA 0.275 0.01 13 0.149 Q5TCY1 E744D Polymorphism NA 0.269 0.01 11 0.130 Q5TCY1 P649R Polymorphism NA 0.180 0.08 2 0.165 Q5TCY1 K1145R Polymorphism NA 0.211 0.02 -24 0.158 Q5TCY1 L1184S Polymorphism NA 0.059 0.00 3 0.041 Q5TCZ1 K659Q Polymorphism 0.194 0.157 0.59 31 0.128 Q5TCZ1 L1073P Polymorphism 0.712 0.747 0.01 36 0.834 Q5TCZ1 R1035Q Polymorphism 0.295 0.279 0.12 45 0.384 Q5TD94 P87S Disease 0.129 0.126 0.16 4 0.064 Q5TD94 A700V Polymorphism 0.287 0.089 0.28 -24 0.069 Q5TD94 N627H Polymorphism 0.703 0.794 0.09 58 0.853 Q5TD94 T149S Polymorphism 0.100 0.085 0.23 13 0.079 Q5TD97 S243R Polymorphism 0.299 0.485 1.00 11 0.209 Q5TD97 V211M Polymorphism 0.394 0.173 0.09 52 0.377 Q5TDP6 G46E Polymorphism NA 0.244 0.00 9 0.160 Q5TEA6 G477S Polymorphism 0.293 0.921 0.07 50 0.545 Q5TEU4 L229P Disease 0.920 0.951 0.00 58 0.948 Q5TEU4 L337F Polymorphism 0.400 0.091 0.02 -10 0.177 Q5TFQ8 T51I Polymorphism 0.281 0.902 0.64 11 0.507 Q5TG30 G133R Polymorphism NA 0.091 0.24 2 0.114 Q5TG30 H463N Polymorphism 0.224 0.659 0.28 -10 0.323 Q5TG30 R413L Polymorphism 0.215 0.720 0.65 -11 0.302 Q5TGL8 P189Q Polymorphism NA 0.087 NA 12 0.084 Q5TGP6 N29S Polymorphism 0.283 0.116 NA -7 0.019 Q5TGY1 R478H Polymorphism 0.442 0.459 0.17 -12 0.353 Q5TH69 S689A Polymorphism NA 0.096 NA 10 0.075 Q5TH69 A1571T Polymorphism 0.162 0.055 0.49 3 0.074 Q5THJ4 A225T Polymorphism 0.157 0.133 0.35 18 0.160 Q5THK1 D963N Polymorphism NA 0.059 NA 14 0.035 Q5THK1 N455S Polymorphism NA 0.018 NA -9 0.022 Q5THK1 V1784I Polymorphism 0.171 0.060 NA 0 0.049 Q5THR3 D780N Polymorphism NA 0.127 0.01 11 0.080 Q5THR3 R199G Polymorphism NA 0.470 0.06 21 0.567 Q5THR3 R800W Polymorphism NA 0.203 0.01 48 0.377 Q5THR3 S384A Polymorphism NA 0.032 0.28 -14 0.051 Q5THR3 T351A Polymorphism NA 0.083 0.05 43 0.086 Q5THR3 V166A Polymorphism NA 0.096 0.12 28 0.096 Q5THR3 A1059V Polymorphism NA 0.076 1.00 -30 0.065 Q5TIA1 E657Q Polymorphism NA 0.104 NA 11 0.088 Q5TID7 F238I Polymorphism 0.447 0.267 0.00 20 0.188 Q5TID7 S323C Polymorphism 0.670 0.311 0.00 34 0.421 Q5TIE3 A319S Polymorphism NA 0.286 0.15 28 0.336 Q5TIE3 K634R Polymorphism 0.206 0.078 0.11 24 0.108 Q5TIE3 N469S Polymorphism NA 0.144 0.31 -3 0.181 Q5TYW1 S68Y Polymorphism 0.662 0.435 0.18 35 0.680 Q5TZA2 A439V Polymorphism 0.209 0.099 0.55 1 0.126 Q5TZA2 D586H Polymorphism 0.783 0.104 0.11 -4 0.285 Q5TZA2 R1097P Polymorphism 0.913 0.396 0.27 45 0.630 Q5U5R9 P19A Polymorphism NA 0.042 1.00 -43 0.019 Q5U5Z8 I90R Polymorphism NA 0.486 0.00 40 0.561 Q5U5Z8 D368G Polymorphism 0.643 0.681 0.69 33 0.693 Q5U5Z8 M671I Polymorphism 0.497 0.169 0.05 0 0.113 Q5U5Z8 R349H Polymorphism 0.341 0.519 0.35 36 0.452 Q5U5Z8 T333P Polymorphism 0.463 0.806 0.20 -9 0.514 Q5U623 S527L Polymorphism 0.119 0.053 0.12 8 0.088 Q5U649 K51R Polymorphism NA 0.225 NA 15 0.119 Q5U649 N103K Polymorphism NA 0.061 NA 27 0.063 Q5U651 R601C Polymorphism 0.094 0.350 0.00 37 0.406 Q5UIP0 M2165R Polymorphism 0.525 0.324 NA 31 0.435 Q5UIP0 V1362M Polymorphism 0.065 0.105 0.06 28 0.079 Q5VIY5 G477R Polymorphism 0.597 0.350 0.63 1 0.199 Q5VST6 R154K Polymorphism 0.190 0.339 0.52 -33 0.252 Q5VST9 A908T Polymorphism NA 0.645 0.20 0 0.444 Q5VST9 G804S Polymorphism NA 0.330 0.72 0 0.254 Q5VST9 A1101P Polymorphism NA 0.693 0.95 0 0.378 Q5VST9 A1532V Polymorphism NA 0.585 0.34 0 0.325 Q5VST9 A1601T Polymorphism NA 0.224 0.77 0 0.271 Q5VST9 E3372D Polymorphism NA 0.770 0.62 0 0.422 Q5VST9 F2116L Polymorphism NA 0.349 0.73 0 0.151 Q5VST9 G1121R Polymorphism NA 0.615 0.59 0 0.211 Q5VST9 G4039R Polymorphism NA 0.735 0.34 0 0.262 Q5VST9 K1027R Polymorphism NA 0.659 0.44 0 0.408 Q5VST9 L5269V Polymorphism NA 0.073 1.00 0 0.078 Q5VST9 Q5891E Polymorphism NA 0.088 1.00 0 0.059 Q5VST9 R2529Q Polymorphism NA 0.635 0.57 0 0.104 Q5VST9 R2812W Polymorphism NA 0.808 0.07 0 0.788 Q5VST9 R3834G Polymorphism NA 0.587 0.35 0 0.570 Q5VST9 R4516W Polymorphism NA 0.593 0.03 0 0.625 Q5VST9 R5598Q Polymorphism NA 0.220 0.00 0 0.408 Q5VST9 S3373C Polymorphism NA 0.846 0.12 0 0.484 Q5VST9 S4642C Polymorphism NA 0.669 0.10 0 0.527 Q5VST9 T1566M Polymorphism NA 0.717 0.22 0 0.436 Q5VT06 E945Q Polymorphism NA 0.097 NA -19 0.023 Q5VT06 R892T Polymorphism NA 0.313 NA 51 0.410 Q5VT06 G1213V Polymorphism NA 0.103 NA 29 0.107 Q5VT25 T231M Polymorphism 0.314 0.461 0.68 39 0.389 Q5VT25 Y790C Polymorphism 0.324 0.311 0.21 -2 0.089 Q5VT25 A1469V Polymorphism 0.350 0.237 0.00 15 0.387 Q5VT25 A1699V Polymorphism 0.142 0.155 0.02 46 0.299 Q5VT25 A1712V Polymorphism 0.064 0.077 0.29 -10 0.027 Q5VT25 R1211H Polymorphism 0.570 0.558 0.00 -9 0.516 Q5VT25 T1618A Polymorphism 0.190 0.079 0.14 23 0.098 Q5VT66 C246S Polymorphism 0.398 0.661 0.64 13 0.451 Q5VT66 M187K Polymorphism 0.365 0.804 0.40 -6 0.707 Q5VT66 M268I Polymorphism 0.640 0.575 0.45 21 0.765 Q5VT66 T165A Polymorphism 0.803 0.228 0.53 -45 0.356 Q5VT79 A177G Polymorphism 0.073 0.601 0.37 -21 0.045 Q5VTE6 P97S Polymorphism NA 0.161 1.00 -12 0.054 Q5VTH9 C33W Polymorphism NA 0.409 NA 51 0.112 Q5VTH9 G16A Polymorphism NA 0.075 NA -43 0.013 Q5VTH9 R832Q Polymorphism NA 0.147 0.02 47 0.145 Q5VTJ3 H273N Polymorphism NA 0.024 0.98 -9 0.013 Q5VTM1 V35L Polymorphism NA 0.285 0.00 20 0.171 Q5VTQ0 T62P Polymorphism NA 0.116 0.30 -25 0.106 Q5VTT5 M344T Polymorphism NA 0.463 0.91 51 0.145 Q5VTT5 I1066T Polymorphism 0.450 0.168 0.45 51 0.186 Q5VTT5 R1124Q Polymorphism 0.248 0.154 0.33 39 0.190 Q5VTY9 E165G Polymorphism 0.579 0.355 0.34 26 0.424 Q5VTY9 S182N Polymorphism 0.470 0.793 0.00 52 0.858 Q5VU43 I49T Polymorphism 0.275 0.833 0.03 13 0.684 Q5VU43 N13S Polymorphism 0.252 0.226 0.26 -1 0.218 Q5VU43 E391A Polymorphism 0.197 0.139 0.22 29 0.257 Q5VU43 H482R Polymorphism 0.156 0.066 0.37 7 0.050 Q5VU43 R681H Polymorphism 0.687 0.517 0.01 38 0.629 Q5VU43 F1013I Polymorphism 0.059 0.094 0.70 17 0.044 Q5VU43 K1359E Polymorphism 0.105 0.053 0.11 15 0.091 Q5VU65 V1491I Polymorphism 0.383 0.410 0.00 32 0.334 Q5VU92 D19G Polymorphism 0.125 0.027 1.00 2 0.016 Q5VU97 M414T Polymorphism 0.105 0.127 0.21 27 0.094 Q5VUA4 L870V Polymorphism 0.278 0.248 0.09 10 0.357 Q5VUA4 S407I Polymorphism 0.376 0.213 NA 30 0.397 Q5VUA4 A1580T Polymorphism 0.293 0.119 NA -15 0.072 Q5VUA4 T1583I Polymorphism NA 0.131 NA -2 0.076 Q5VUA4 V1797A Polymorphism 0.044 0.044 NA -7 0.021 Q5VV43 G919A Polymorphism NA 0.509 0.21 51 0.748 Q5VV43 T142P Polymorphism NA 0.027 0.21 -44 0.008 Q5VV43 Y1013C Polymorphism NA 0.211 0.19 -5 0.328 Q5VV67 S536G Polymorphism 0.074 0.033 0.06 -24 0.025 Q5VVB8 F80L Polymorphism NA 0.162 NA -28 0.009 Q5VVJ2 T264A Polymorphism 0.055 0.030 1.00 -4 0.040 Q5VW36 I523V Polymorphism NA 0.101 NA -35 0.057 Q5VW36 K1668E Polymorphism 0.099 0.058 NA -14 0.021 Q5VW36 T1373P Polymorphism NA 0.528 NA 31 0.695 Q5VW38 A189P Polymorphism NA 0.214 0.31 -32 0.194 Q5VWG9 N442S Polymorphism NA 0.207 0.69 19 0.074 Q5VWG9 S349T Polymorphism NA 0.154 0.03 18 0.191 Q5VWG9 V696A Polymorphism NA 0.097 0.75 17 0.073 Q5VWG9 V696L Polymorphism NA 0.098 0.31 20 0.073 Q5VWI1 E529K Polymorphism 0.445 0.649 0.12 33 0.752 Q5VWI1 P339Q Polymorphism 0.501 0.822 0.21 31 0.761 Q5VWI1 Q566K Polymorphism 0.173 0.300 0.16 5 0.354 Q5VWK5 Q3H Polymorphism NA 0.193 0.05 -64 0.182 Q5VWN6 C499G Polymorphism NA 0.035 NA 6 0.018 Q5VWN6 P1578S Polymorphism NA 0.154 NA 21 0.033 Q5VWN6 R1075P Polymorphism NA 0.082 NA -12 0.010 Q5VWN6 S2404N Polymorphism NA 0.066 0.30 2 0.088 Q5VWN6 V1679A Polymorphism NA 0.071 NA 6 0.064 Q5VWP2 H67Q Polymorphism 0.159 0.301 0.41 25 0.066 Q5VWP3 R6H Polymorphism NA 0.022 NA -29 0.018 Q5VWQ8 S59F Polymorphism NA 0.222 0.08 36 0.414 Q5VWT5 I125M Polymorphism 0.370 0.129 NA 15 0.114 Q5VWX1 G308A Polymorphism 0.250 0.263 0.00 -2 0.324 Q5VWZ2 I131M Polymorphism 0.094 0.786 0.15 -23 0.110 Q5VX52 V153L Polymorphism NA 0.229 NA 20 0.129 Q5VXM1 G244R Polymorphism 0.560 0.507 0.12 24 0.368 Q5VXU9 H416R Polymorphism NA 0.032 NA 9 0.030 Q5VXU9 I649T Polymorphism NA 0.182 NA 9 0.153 Q5VXU9 L968P Polymorphism NA 0.365 NA 38 0.146 Q5VXU9 N809K Polymorphism NA 0.284 NA 35 0.137 Q5VXU9 T226S Polymorphism NA 0.159 NA 24 0.039 Q5VXU9 Y932C Polymorphism NA 0.148 NA 8 0.017 Q5VXU9 N1380K Polymorphism NA 0.084 NA 0 0.054 Q5VY09 R92H Polymorphism 0.171 0.137 0.33 11 0.042 Q5VY09 P285S Polymorphism 0.844 0.135 0.00 -18 0.564 Q5VY09 Q202R Polymorphism 0.095 0.056 0.51 0 0.034 Q5VY09 V168I Polymorphism 0.196 0.064 0.56 -4 0.028 Q5VY43 R885H Polymorphism 0.209 0.227 0.16 -6 0.226 Q5VY43 S234P Polymorphism NA 0.324 1.00 10 0.194 Q5VY80 M85T Polymorphism NA 0.150 0.22 0 0.138 Q5VYJ5 D809G Polymorphism NA 0.874 0.57 49 0.868 Q5VYJ5 K653N Polymorphism NA 0.631 0.46 50 0.434 Q5VYJ5 V713A Polymorphism NA 0.575 0.86 29 0.316 Q5VYJ5 H1087Q Polymorphism NA 0.219 0.28 34 0.152 Q5VYJ5 L1049I Polymorphism NA 0.146 NA 16 0.137 Q5VYJ5 M1379R Polymorphism NA 0.707 0.04 27 0.495 Q5VYM1 L285F Polymorphism NA 0.068 0.73 10 0.037 Q5VYM1 S623T Polymorphism 0.261 0.052 0.38 -1 0.035 Q5VYX0 E37D Polymorphism 0.079 0.141 NA 10 0.119 Q5VYY1 R177I Polymorphism 0.592 0.292 0.49 5 0.502 Q5VZ03 S76C Polymorphism 0.262 0.229 0.00 21 0.354 Q5VZ19 R181Q Polymorphism NA 0.249 0.00 38 0.129 Q5VZ19 V215I Polymorphism NA 0.032 0.09 -8 0.029 Q5VZ46 H214Y Polymorphism NA 0.076 NA 29 0.059 Q5VZ46 L801F Polymorphism NA 0.053 NA 34 0.039 Q5VZ66 M493V Polymorphism 0.056 0.107 0.47 30 0.098 Q5VZ89 N1107H Polymorphism 0.304 0.122 0.75 19 0.102 Q5VZ89 T1030A Polymorphism 0.170 0.138 0.15 0 0.097 Q5VZK9 P545L Polymorphism 0.666 0.155 0.24 41 0.390 Q5VZP5 A505T Polymorphism NA 0.097 0.21 0 0.021 Q5VZP5 T1124N Polymorphism NA 0.221 0.00 18 0.125 Q5VZQ5 E38Q Polymorphism NA 0.059 NA 12 0.120 Q5VZV1 N46S Polymorphism 0.195 0.074 0.08 -14 0.050 Q5W041 E345G Polymorphism 0.378 0.267 0.29 52 0.437 Q5W041 R626Q Polymorphism 0.094 0.078 NA -4 0.044 Q5W041 S608P Polymorphism 0.504 0.204 NA -23 0.193 Q5W0A0 E63D Polymorphism 0.233 0.191 0.33 20 0.152 Q5W0A0 H453R Polymorphism 0.370 0.035 0.00 20 0.074 Q5W0A0 L303P Polymorphism 0.680 0.149 0.00 19 0.071 Q5W0A0 P439R Polymorphism 0.565 0.023 0.14 28 0.078 Q5W0A0 S174T Polymorphism 0.283 0.156 0.00 23 0.161 Q5W0A0 T427I Polymorphism 0.365 0.139 0.00 45 0.228 Q5W0A0 V653F Polymorphism 0.445 0.086 0.11 4 0.101 Q5W0Q7 P384S Polymorphism 0.328 0.486 NA 18 0.589 Q5W0Q7 S950N Polymorphism 0.072 0.033 NA 12 0.035 Q5W0U4 Q293H Polymorphism 0.217 0.733 0.17 5 0.424 Q5W0U4 T374I Polymorphism 0.120 0.558 0.01 2 0.242 Q5W0V3 F631L Polymorphism 0.378 0.553 0.03 10 0.534 Q5W0V3 L408I Polymorphism 0.616 0.284 0.38 3 0.417 Q5W186 L48F Polymorphism 0.118 0.055 0.17 -5 0.060 Q5XG87 G396S Polymorphism 0.096 0.035 NA -27 0.016 Q5XG99 A157V Polymorphism NA 0.069 0.56 -23 0.071 Q5XKE5 F195L Polymorphism 0.602 0.727 0.20 1 0.601 Q5XKL5 V60I Polymorphism NA 0.210 0.24 38 0.078 Q5XKR9 S60G Polymorphism NA 0.057 NA 38 0.053 Q5XPI4 K596E Polymorphism 0.190 0.133 NA 1 0.119 Q5XX13 A821T Polymorphism 0.143 0.198 0.00 43 0.184 Q5XXA6 F608S Polymorphism 0.551 0.522 0.03 15 0.583 Q5XXA6 G983R Polymorphism 0.155 0.135 NA 51 0.147 Q5ZPR3 P97L Polymorphism 0.151 0.491 0.31 37 0.182 Q5ZPR3 P315L Polymorphism 0.417 0.500 0.35 0 0.385 Q5ZPR3 Q137L Polymorphism 0.349 0.660 0.07 35 0.553 Q5ZPR3 R111S Polymorphism 0.284 0.532 0.37 37 0.441 Q5ZPR3 R329S Polymorphism 0.300 0.467 0.75 29 0.308 Q5ZPR3 T160M Polymorphism 0.079 0.127 0.11 38 0.194 Q5ZPR3 T378M Polymorphism 0.451 0.184 0.16 39 0.377 Q60I27 E45Q Polymorphism NA 0.131 0.14 1 0.116 Q63HK3 E615D Polymorphism NA 0.180 0.55 32 0.183 Q63HK3 L253F Polymorphism NA 0.506 0.02 40 0.529 Q63HK3 P947S Polymorphism NA 0.133 0.21 33 0.159 Q63HK5 P687L Polymorphism 0.549 0.148 0.10 3 0.166 Q63HM2 Q770H Polymorphism NA 0.215 NA 14 0.202 Q63HM2 G1000S Polymorphism 0.234 0.055 0.04 -17 0.027 Q63HN1 N72K Polymorphism 0.289 0.319 0.75 49 0.221 Q63HN1 D203E Polymorphism 0.383 0.035 1.00 -1 0.020 Q63HN8 S407N Polymorphism NA 0.112 NA -30 0.117 Q63HN8 H2764R Polymorphism 0.879 0.101 NA 12 0.234 Q63HN8 K2805E Polymorphism 0.275 0.111 NA 33 0.103 Q63HN8 V1911L Polymorphism NA 0.173 NA 13 0.137 Q63HQ0 T297I Polymorphism NA 0.101 NA 33 0.081 Q63HQ2 H576N Polymorphism 0.444 0.434 1.00 23 0.298 Q63HQ2 V745M Polymorphism 0.433 0.699 0.14 -5 0.464 Q63HQ2 W229R Polymorphism 0.534 0.200 0.88 53 0.225 Q63ZY3 G118S Polymorphism NA 0.184 0.85 -45 0.152 Q63ZY6 A90V Polymorphism 0.448 0.623 0.56 37 0.583 Q63ZY6 W47S Polymorphism 0.161 0.549 0.01 40 0.342 Q63ZY6 K303R Polymorphism NA 0.107 NA 3 0.032 Q64LD2 W88R Polymorphism NA 0.114 NA 47 0.029 Q64LD2 T119M Polymorphism NA 0.076 NA -15 0.028 Q658N2 H212Y Polymorphism NA 0.218 1.00 36 0.159 Q658Y4 I704V Polymorphism NA 0.062 0.54 -6 0.068 Q659C4 R660H Polymorphism 0.785 0.079 0.98 -27 0.022 Q66GS9 I769L Polymorphism 0.065 0.042 0.79 -51 0.019 Q66K74 L372V Polymorphism 0.218 0.709 0.02 37 0.555 Q66K74 P538Q Polymorphism 0.362 0.104 0.34 26 0.182 Q66K79 P6L Polymorphism NA 0.288 1.00 0 0.090 Q66K79 Q130L Polymorphism NA 0.125 0.22 1 0.087 Q66K80 R231S Polymorphism NA 0.282 NA 35 0.029 Q674X7 A706T Polymorphism 0.153 0.122 0.05 16 0.110 Q676U5 E307K Polymorphism 0.259 0.329 0.81 27 0.373 Q676U5 T300A Polymorphism 0.192 0.094 1.00 -27 0.110 Q67FW5 A341T Polymorphism 0.513 0.049 0.15 2 0.105 Q685J3 K227Q Polymorphism NA 0.032 0.59 48 0.035 Q685J3 T982M Polymorphism NA 0.086 0.17 53 0.146 Q685J3 D4334N Polymorphism NA 0.303 0.17 13 0.232 Q685J3 P1249A Polymorphism NA 0.158 0.86 40 0.307 Q685J3 T1246N Polymorphism NA 0.137 0.33 -1 0.236 Q685J3 T1246S Polymorphism NA 0.105 0.82 24 0.192 Q687X5 G75D Polymorphism 0.355 0.142 1.00 26 0.114 Q687X5 A122T Polymorphism 0.554 0.882 0.03 20 0.772 Q68BL7 R425Q Polymorphism 0.111 0.632 0.50 33 0.141 Q68BL8 Y10C Polymorphism NA 0.077 0.13 -54 0.018 Q68BL8 W470R Polymorphism NA 0.123 0.66 37 0.117 Q68CJ6 R492W Polymorphism NA 0.280 NA 38 0.417 Q68CL5 R47C Polymorphism NA 0.310 NA 30 0.371 Q68CP4 D590V Disease NA 0.965 NA 49 0.889 Q68CP4 E499K Disease NA 0.965 NA 59 0.925 Q68CP4 G452S Disease NA 0.658 NA 49 0.623 Q68CP4 M510K Disease NA 0.466 NA 16 0.550 Q68CP4 P311L Disease NA 0.919 NA 31 0.840 Q68CP4 P599L Disease NA 0.821 NA 22 0.596 Q68CP4 R372C Disease NA 0.976 NA 67 0.934 Q68CP4 S569L Disease NA 0.967 NA 39 0.853 Q68CQ1 E316G Polymorphism 0.441 0.076 0.16 0 0.025 Q68CQ1 H182R Polymorphism NA 0.103 0.16 21 0.068 Q68CQ1 K455R Polymorphism 0.654 0.181 0.10 21 0.231 Q68CQ1 S312F Polymorphism 0.617 0.275 0.00 36 0.521 Q68CQ1 V290M Polymorphism 0.612 0.122 0.00 -17 0.050 Q68CQ1 V509A Polymorphism 0.434 0.182 0.02 30 0.336 Q68CQ1 Y306D Polymorphism 0.393 0.173 0.56 17 0.025 Q68CQ7 R210H Polymorphism NA 0.209 0.02 43 0.343 Q68CR1 I554V Polymorphism NA 0.101 0.03 -9 0.109 Q68CZ1 A695P Disease 0.682 0.758 0.01 37 0.834 Q68CZ1 T615P Disease 0.596 0.491 0.04 47 0.729 Q68CZ6 I586T Polymorphism 0.463 0.120 NA 9 0.107 Q68D06 D642V Polymorphism 0.646 0.234 0.23 -7 0.485 Q68D06 E652K Polymorphism 0.070 0.067 1.00 -26 0.021 Q68D10 R447Q Polymorphism 0.330 0.179 0.44 30 0.104 Q68D51 D2E Polymorphism NA 0.294 0.00 9 0.193 Q68D86 C346F Polymorphism 0.611 0.185 0.07 0 0.266 Q68D86 E370G Polymorphism 0.394 0.320 0.04 37 0.495 Q68D86 K153N Polymorphism NA 0.043 0.50 7 0.062 Q68DA7 L686P Polymorphism NA 0.106 0.11 -27 0.009 Q68DD2 G30V Polymorphism NA 0.333 0.00 0 0.465 Q68DE3 V943G Polymorphism NA 0.239 NA 35 0.172 Q68DK2 T951M Polymorphism NA 0.032 0.02 34 0.096 Q68DK2 P1103L Polymorphism NA 0.178 0.00 12 0.165 Q68DK2 S1071N Polymorphism NA 0.072 0.00 11 0.174 Q68DK2 S1891N Polymorphism 0.096 0.115 0.45 34 0.123 Q68DN1 A660E Polymorphism NA 0.073 NA 13 0.034 Q68DN1 D505V Polymorphism NA 0.262 NA 8 0.175 Q68DN1 I767T Polymorphism NA 0.376 NA 47 0.135 Q68DN1 I774V Polymorphism NA 0.209 NA 33 0.195 Q68DN1 H1559Y Polymorphism NA 0.064 0.03 39 0.087 Q68DN1 S1500F Polymorphism NA 0.075 0.00 34 0.192 Q68DN1 S1665P Polymorphism NA 0.149 0.09 -29 0.093 Q68DQ2 N926H Polymorphism 0.065 0.110 0.01 45 0.205 Q68DQ2 Y761C Polymorphism 0.787 0.876 0.00 60 0.722 Q68DV7 I47V Polymorphism NA 0.042 0.03 -20 0.096 Q68DV7 P231L Polymorphism 0.881 0.156 0.11 47 0.288 Q68DV7 R117H Polymorphism 0.588 0.115 0.00 67 0.292 Q68DV7 R221Q Polymorphism 0.503 0.162 0.05 57 0.212 Q68DV7 R343H Polymorphism 0.594 0.288 0.04 24 0.480 Q68DX3 A20T Polymorphism NA 0.196 0.05 12 0.242 Q68DX3 K534E Polymorphism NA 0.176 1.00 2 0.083 Q68DY1 M65T Polymorphism 0.388 0.378 0.66 31 0.443 Q68DY1 N68H Polymorphism 0.321 0.204 0.27 -30 0.187 Q68DY1 Q89E Polymorphism 0.502 0.397 0.68 21 0.483 Q68DY1 C464Y Polymorphism 0.326 0.309 1.00 -4 0.178 Q68DY1 E500K Polymorphism 0.447 0.209 0.34 -16 0.160 Q68DY9 C182W Polymorphism 0.850 0.583 0.19 15 0.599 Q68DY9 M218L Polymorphism 0.177 0.387 0.03 -14 0.116 Q68EA5 R230W Polymorphism 0.754 0.329 0.01 58 0.529 Q68EA5 T223N Polymorphism 0.564 0.269 0.02 -14 0.113 Q68G75 P25S Polymorphism NA 0.244 NA 28 0.165 Q695T7 R57C Disease 0.981 0.954 0.00 52 0.948 Q695T7 D173N Disease 0.453 0.179 0.38 -26 0.208 Q695T7 E501K Disease 0.921 0.939 0.03 54 0.929 Q695T7 L242P Disease 0.913 0.930 0.00 35 0.884 Q695T7 V252I Polymorphism 0.084 0.079 0.55 -61 0.088 Q69YN2 C160Y Polymorphism 0.093 0.326 0.67 -11 0.037 Q69YN2 P259L Polymorphism 0.225 0.181 0.47 0 0.257 Q69YN2 R523H Polymorphism 0.367 0.242 0.12 -11 0.374 Q6A162 F85S Polymorphism 0.699 0.340 0.00 16 0.623 Q6A162 T37A Polymorphism 0.241 0.146 0.53 -28 0.128 Q6A162 R235H Polymorphism 0.622 0.556 0.01 -14 0.537 Q6A162 T153M Polymorphism 0.484 0.264 0.00 -27 0.386 Q6A163 L383M Polymorphism 0.780 0.334 0.07 -12 0.456 Q6A555 N60H Polymorphism NA 0.266 0.01 17 0.119 Q6AHZ1 N946H Polymorphism NA 0.152 NA 45 0.110 Q6AHZ1 R1328Q Polymorphism NA 0.349 NA 26 0.521 Q6AI08 A71V Polymorphism 0.294 0.085 0.13 10 0.086 Q6AI08 S1006L Polymorphism 0.273 0.068 0.10 -14 0.083 Q6AW86 S63G Polymorphism NA 0.083 0.22 -13 0.186 Q6AWC2 A773S Polymorphism 0.234 0.044 1.00 -15 0.060 Q6AWC2 D904H Polymorphism 0.113 0.063 0.07 15 0.108 Q6AWC2 V816F Polymorphism 0.115 0.180 0.16 47 0.219 Q6AWC2 A1189T Polymorphism 0.213 0.447 0.00 14 0.412 Q6AZY7 F467L Polymorphism 0.067 0.368 0.67 0 0.138 Q6AZY7 R130Q Polymorphism NA 0.094 0.36 12 0.074 Q6B0I6 A471S Polymorphism NA 0.139 NA -18 0.048 Q6B0I6 R408Q Polymorphism NA 0.077 0.48 42 0.072 Q6BCY4 E15A Polymorphism 0.261 0.266 0.57 8 0.308 Q6BDS2 K404N Polymorphism 0.354 0.052 1.00 5 0.066 Q6BDS2 K854E Polymorphism 0.192 0.076 0.05 -20 0.095 Q6BDS2 Q454R Polymorphism 0.248 0.050 0.40 1 0.057 Q6BDS2 Q984H Polymorphism 0.344 0.057 0.02 17 0.134 Q6BDS2 M1098T Polymorphism 0.476 0.652 0.00 49 0.681 Q6DD87 G379A Polymorphism NA 0.218 1.00 -33 0.166 Q6DHV5 Y237H Polymorphism 0.522 0.175 0.21 18 0.367 Q6DKI2 V126M Polymorphism 0.587 0.338 0.55 12 0.573 Q6DKI7 N81D Polymorphism NA 0.052 NA -22 0.013 Q6DN72 S427G Polymorphism NA 0.030 NA -3 0.024 Q6DN90 P640S Polymorphism 0.243 0.780 0.01 25 0.544 Q6DN90 V882I Polymorphism 0.122 0.165 0.27 0 0.148 Q6E0U4 E69D Polymorphism NA 0.112 0.10 16 0.035 Q6E0U4 N139S Polymorphism NA 0.203 0.23 20 0.067 Q6ECI4 V23L Polymorphism NA 0.441 0.42 8 0.342 Q6EEV4 A127P Polymorphism NA 0.365 NA 40 0.059 Q6EEV6 M55V Polymorphism 0.187 0.416 0.74 -9 0.222 Q6EMB2 A149V Polymorphism 0.099 0.464 0.08 36 0.160 Q6EMB2 A592T Polymorphism NA 0.158 0.02 14 0.096 Q6EMB2 E203D Polymorphism 0.158 0.542 0.09 3 0.196 Q6EMB2 A1223S Polymorphism NA 0.130 0.53 -34 0.011 Q6EMB2 F1267S Polymorphism NA 0.165 0.40 6 0.016 Q6EMK4 E384A Polymorphism 0.067 0.141 0.70 -1 0.121 Q6FHJ7 P320T Polymorphism NA 0.147 0.04 7 0.098 Q6FHJ7 R340K Polymorphism NA 0.076 1.00 26 0.043 Q6FI81 A34E Polymorphism 0.085 0.144 1.00 -19 0.086 Q6GMV1 G184S Polymorphism NA 0.207 0.00 7 0.063 Q6GMV1 I159T Polymorphism 0.064 0.061 0.53 30 0.017 Q6GPH4 E188K Polymorphism 0.280 0.050 0.70 45 0.036 Q6GPH4 R132H Polymorphism 0.507 0.042 0.20 28 0.046 Q6GPH6 G280R Polymorphism NA 0.426 0.07 43 0.457 Q6GPH6 T463M Polymorphism NA 0.143 0.02 22 0.165 Q6GTS8 I380T Polymorphism 0.140 0.295 0.17 -5 0.275 Q6GTX8 E63D Polymorphism 0.472 0.877 0.04 8 0.616 Q6GV28 C196R Polymorphism NA 0.042 0.56 8 0.025 Q6GYQ0 T931A Polymorphism 0.269 0.101 0.11 22 0.044 Q6H9L7 P133A Polymorphism NA 0.049 NA 8 0.069 Q6HA08 K277Q Polymorphism 0.183 0.604 0.29 10 0.252 Q6IA69 M591I Polymorphism 0.236 0.454 0.36 33 0.381 Q6IA69 P297L Polymorphism 0.486 0.419 0.29 11 0.421 Q6IA86 H359R Polymorphism 0.411 0.411 0.44 55 0.688 Q6IA86 H806P Polymorphism 0.382 0.425 0.12 29 0.547 Q6IA86 I541T Polymorphism 0.255 0.210 0.58 -32 0.207 Q6IA86 T128P Polymorphism 0.289 0.636 0.33 -1 0.330 Q6IA86 V305M Polymorphism 0.332 0.052 0.18 -42 0.104 Q6IAA8 S73L Polymorphism 0.339 0.265 NA 29 0.397 Q6IBS0 Q76R Polymorphism 0.266 0.170 0.42 9 0.151 Q6IBS0 R72C Polymorphism 0.901 0.887 0.00 61 0.887 Q6ICG8 C170F Polymorphism NA 0.164 0.08 27 0.149 Q6ICG8 Q285H Polymorphism NA 0.049 0.26 3 0.012 Q6ICL3 D245E Polymorphism 0.406 0.579 0.31 0 0.466 Q6IE36 L587V Polymorphism NA 0.348 0.04 8 0.412 Q6IE36 S789L Polymorphism 0.889 0.898 0.00 45 0.896 Q6IE36 T211M Polymorphism NA 0.080 0.08 -4 0.178 Q6IE81 N662S Polymorphism 0.182 0.122 1.00 -13 0.030 Q6IEE8 A405G Polymorphism 0.209 0.117 0.21 7 0.104 Q6IEE8 C462Y Polymorphism 0.623 0.129 0.39 -11 0.185 Q6IEG0 P45L Polymorphism NA 0.153 NA -11 0.147 Q6IEV9 T277P Polymorphism 0.354 0.927 0.05 51 0.796 Q6IF42 L210P Polymorphism 0.601 0.885 0.09 54 0.761 Q6IF63 T266A Polymorphism 0.070 0.287 0.54 12 0.229 Q6IF82 I104L Polymorphism 0.402 0.234 0.78 -35 0.150 Q6IF82 V145M Polymorphism 0.254 0.355 0.08 -12 0.308 Q6IF99 A208T Polymorphism 0.190 0.097 0.05 -31 0.221 Q6IFN5 P242S Polymorphism 0.147 0.073 1.00 -48 0.163 Q6IFN5 S193F Polymorphism 0.403 0.749 0.02 54 0.864 Q6IMI6 M194T Polymorphism 0.108 0.874 0.57 -6 0.150 Q6IMN6 K237R Polymorphism 0.192 0.173 0.49 16 0.141 Q6IMN6 M519V Polymorphism NA 0.064 0.87 20 0.028 Q6IMN6 S655L Polymorphism 0.394 0.154 0.10 18 0.152 Q6IPM2 A546V Polymorphism NA 0.145 0.02 -12 0.090 Q6IPM2 H101N Polymorphism NA 0.310 NA 24 0.412 Q6IPM2 L666V Polymorphism NA 0.043 NA -45 0.015 Q6IPM2 R587H Polymorphism NA 0.150 NA -17 0.079 Q6IPM2 T596A Polymorphism NA 0.049 NA 12 0.019 Q6IPM2 T690M Polymorphism NA 0.067 NA 0 0.035 Q6IPR3 M121V Polymorphism 0.250 0.070 1.00 9 0.025 Q6IPR3 R110Q Polymorphism 0.165 0.411 0.04 43 0.289 Q6IPT2 S206I Polymorphism 0.874 0.307 0.03 23 0.424 Q6IQ16 R45Q Polymorphism NA 0.782 0.30 34 0.603 Q6IQ20 D389N Polymorphism NA 0.093 0.00 -16 0.111 Q6IQ20 S152A Polymorphism NA 0.177 0.33 -21 0.190 Q6IQ23 A248V Polymorphism NA 0.035 0.08 -9 0.034 Q6IQ23 V693I Polymorphism 0.424 0.071 0.19 8 0.110 Q6IQ49 M312I Polymorphism 0.203 0.077 0.19 31 0.081 Q6IQ55 R500P Polymorphism NA 0.108 0.03 15 0.148 Q6IQ55 P1122R Polymorphism NA 0.181 0.00 17 0.187 Q6IQ55 T1062I Polymorphism NA 0.104 NA 41 0.084 Q6IQ55 V1097A Polymorphism NA 0.246 0.09 35 0.216 Q6ISB3 V415I Polymorphism 0.235 0.550 0.42 13 0.419 Q6ISS4 H87R Polymorphism 0.130 0.201 0.35 6 0.162 Q6ISS4 F115Y Polymorphism 0.079 0.215 0.37 -17 0.117 Q6IV72 D166V Polymorphism NA 0.198 0.46 27 0.263 Q6IWH7 V67I Polymorphism NA 0.066 0.40 -3 0.065 Q6J9G0 R71G Polymorphism 0.305 0.187 0.01 30 0.295 Q6J9G0 L237S Polymorphism 0.580 0.098 0.02 -43 0.280 Q6J9G0 V400L Polymorphism NA 0.235 0.57 -11 0.212 Q6JBY9 Q384R Polymorphism 0.147 0.049 0.63 9 0.036 Q6JQN1 T216P Polymorphism NA 0.148 0.03 29 0.057 Q6KB66 V238I Polymorphism 0.430 0.443 0.29 -17 0.340 Q6KC79 N674S Polymorphism 0.172 0.033 0.40 31 0.042 Q6KC79 S135N Polymorphism 0.303 0.094 NA 21 0.077 Q6KC79 A1246G Disease 0.506 0.278 0.26 0 0.499 Q6KC79 A2390T Disease 0.182 0.596 0.19 0 0.343 Q6KC79 C1311R Disease 0.401 0.471 0.05 52 0.656 Q6KC79 D1803V Disease 0.944 0.934 0.01 57 0.952 Q6KC79 G2312R Disease 0.951 0.959 0.00 50 0.957 Q6KC79 G2381A Disease 0.421 0.429 0.28 -4 0.295 Q6KC79 L1312P Disease 0.145 0.813 0.01 56 0.869 Q6KC79 L1348R Disease 0.722 0.733 0.01 55 0.880 Q6KC79 R1789L Disease 0.905 0.958 0.00 57 0.946 Q6KC79 R1856T Disease 0.904 0.774 0.13 43 0.897 Q6KC79 R2298C Disease 0.968 0.727 0.02 51 0.915 Q6KC79 R2298H Disease 0.926 0.566 0.06 51 0.858 Q6KC79 Y2430C Disease 0.817 0.727 0.01 42 0.861 Q6KC79 Y2440H Disease 0.640 0.802 0.00 56 0.823 Q6L8H2 G27S Polymorphism 0.364 0.190 0.23 34 0.036 Q6L8Q7 R23W Polymorphism NA 0.272 0.03 48 0.249 Q6L9W6 G59S Polymorphism NA 0.068 0.00 -7 0.115 Q6L9W6 K411R Polymorphism NA 0.082 0.00 27 0.189 Q6L9W6 R265Q Polymorphism NA 0.059 0.33 35 0.108 Q6MZM0 N251D Polymorphism 0.328 0.211 0.97 16 0.246 Q6MZM0 R381C Polymorphism 0.253 0.276 0.00 24 0.354 Q6MZM9 R91C Polymorphism NA 0.186 NA 12 0.118 Q6MZN7 W82C Polymorphism NA 0.589 NA 33 0.465 Q6MZN7 H123R Polymorphism NA 0.261 NA 22 0.056 Q6MZN7 V112G Polymorphism NA 0.383 NA 31 0.206 Q6MZW2 R158H Polymorphism NA 0.209 0.01 25 0.261 Q6N021 L34F Polymorphism 0.589 0.050 NA 40 0.080 Q6N021 P29R Polymorphism 0.356 0.092 NA 23 0.077 Q6N021 A912G Polymorphism 0.753 0.123 NA -3 0.183 Q6N021 G355D Polymorphism 0.561 0.278 NA 37 0.504 Q6N021 G429R Polymorphism 0.485 0.234 NA 22 0.162 Q6N021 H924R Polymorphism 0.494 0.081 NA 25 0.058 Q6N021 H949R Polymorphism 0.417 0.257 NA 16 0.340 Q6N021 P174H Polymorphism 0.550 0.064 NA 7 0.066 Q6N021 P363L Polymorphism 0.448 0.100 NA -12 0.068 Q6N021 R123H Polymorphism 0.503 0.039 NA 30 0.023 Q6N021 V218M Polymorphism 0.216 0.038 NA 42 0.028 Q6N021 Y867H Polymorphism 0.591 0.393 NA 33 0.587 Q6N021 D1242R Polymorphism NA 0.924 0.00 20 0.822 Q6N021 E1073V Polymorphism 0.316 0.194 NA 11 0.315 Q6N021 H1778R Polymorphism NA 0.079 0.37 30 0.053 Q6N021 I1762V Polymorphism NA 0.118 0.46 23 0.087 Q6N021 L1721W Polymorphism NA 0.260 0.05 30 0.136 Q6N021 M1701I Polymorphism NA 0.075 0.32 38 0.056 Q6N021 P1723S Polymorphism NA 0.152 0.49 8 0.056 Q6N021 Q1084P Polymorphism 0.642 0.185 0.30 13 0.375 Q6N021 R2000K Polymorphism NA 0.431 0.27 16 0.329 Q6N021 V1900A Polymorphism NA 0.700 0.00 29 0.770 Q6N022 E506Q Polymorphism 0.116 0.240 0.07 47 0.292 Q6N043 K781I Polymorphism NA 0.087 0.00 47 0.137 Q6N043 V568I Polymorphism NA 0.129 0.02 28 0.090 Q6NSI4 I593M Polymorphism NA 0.065 NA 25 0.071 Q6NSJ0 F385Y Polymorphism 0.552 0.818 0.13 23 0.596 Q6NSJ0 R199S Polymorphism 0.295 0.213 0.26 -5 0.115 Q6NSJ2 Q239R Polymorphism NA 0.215 0.66 -2 0.206 Q6NSJ5 E181G Polymorphism NA 0.130 0.19 2 0.136 Q6NSJ5 M190T Polymorphism NA 0.165 1.00 -2 0.075 Q6NSX1 I206V Polymorphism 0.048 0.067 0.74 -50 0.029 Q6NSZ9 P325A Polymorphism 0.380 0.071 0.51 7 0.129 Q6NT16 V204I Polymorphism 0.223 0.071 0.04 -41 0.093 Q6NT32 R71Q Polymorphism 0.976 0.860 0.00 51 0.936 Q6NT32 E261K Polymorphism 0.066 0.188 0.33 11 0.141 Q6NT32 G499R Polymorphism 0.996 0.894 0.04 54 0.899 Q6NT32 H344Q Polymorphism 0.123 0.339 0.83 8 0.200 Q6NT55 F59L Disease 0.871 0.686 0.03 17 0.783 Q6NT55 H435Y Disease 0.714 0.913 0.00 63 0.920 Q6NT55 H436D Disease 0.630 0.830 0.01 58 0.904 Q6NT55 K505Q Polymorphism NA 0.064 0.14 -22 0.130 Q6NT55 R243H Disease 0.821 0.846 0.00 40 0.794 Q6NT55 R372W Disease NA 0.594 0.00 41 0.794 Q6NT55 S178C Polymorphism 0.487 0.399 0.00 -26 0.305 Q6NT89 W27R Polymorphism NA 0.193 NA 17 0.045 Q6NTE8 Q42R Polymorphism NA 0.067 0.86 -1 0.069 Q6NTE8 Q97R Polymorphism NA 0.049 0.45 27 0.126 Q6NTE8 R154G Polymorphism NA 0.101 0.18 1 0.071 Q6NTF7 E178D Polymorphism 0.133 0.258 0.02 -15 0.255 Q6NTF7 G105R Polymorphism 0.605 0.367 0.86 -9 0.011 Q6NTF7 K121E Polymorphism 0.302 0.171 1.00 -34 0.093 Q6NUI1 G82D Polymorphism 0.599 0.236 0.15 4 0.260 Q6NUI6 Q710R Polymorphism 0.287 0.368 1.00 19 0.340 Q6NUJ1 V296M Polymorphism 0.746 0.096 0.05 45 0.179 Q6NUJ5 R89C Polymorphism NA 0.121 0.06 10 0.054 Q6NUJ5 R98G Polymorphism NA 0.101 0.22 11 0.038 Q6NUM9 A533V Polymorphism 0.316 0.228 0.28 40 0.360 Q6NUM9 G536R Polymorphism 0.906 0.940 0.08 73 0.946 Q6NUM9 P559T Polymorphism 0.382 0.562 0.49 9 0.539 Q6NUN0 E182K Polymorphism 0.213 0.189 0.71 -7 0.222 Q6NUN0 H360R Polymorphism 0.402 0.250 0.80 -44 0.165 Q6NUN0 T533M Polymorphism NA 0.091 0.06 -20 0.178 Q6NUQ1 S40C Polymorphism 0.833 0.154 NA 32 0.091 Q6NUQ4 V351M Polymorphism 0.556 0.198 0.00 25 0.445 Q6NUS8 C121G Polymorphism 0.969 0.857 0.00 56 0.955 Q6NUT2 S51A Polymorphism NA 0.040 0.73 -24 0.011 Q6NUT3 I203V Polymorphism NA 0.068 0.70 27 0.083 Q6NUT3 R243H Polymorphism NA 0.295 0.16 3 0.299 Q6NUT3 R476C Polymorphism NA 0.210 NA 46 0.111 Q6NUT3 Y182H Polymorphism NA 0.941 0.53 61 0.895 Q6NVH7 D171G Polymorphism NA 0.300 NA 30 0.152 Q6NVV3 I324V Polymorphism 0.465 0.544 0.18 -12 0.465 Q6NVY1 Y122C Disease 0.988 0.914 0.01 62 0.942 Q6NW34 F357I Polymorphism NA 0.207 NA -21 0.201 Q6NW34 P352S Polymorphism NA 0.158 NA 9 0.095 Q6NW34 S490P Polymorphism NA 0.250 NA 26 0.185 Q6NW34 T476A Polymorphism NA 0.153 NA 23 0.144 Q6NX45 P65L Polymorphism 0.098 0.296 0.83 4 0.229 Q6NX45 V147I Polymorphism 0.154 0.361 0.04 -26 0.203 Q6NX49 H203D Polymorphism NA 0.708 0.02 76 0.903 Q6NXG1 Y196C Polymorphism 0.141 0.213 0.11 4 0.203 Q6NXP0 E66G Polymorphism NA 0.097 NA 46 0.071 Q6NXP0 P541S Polymorphism NA 0.138 NA -34 0.023 Q6NXP2 I251V Polymorphism 0.432 0.063 0.95 -30 0.031 Q6NXP2 P112T Polymorphism NA 0.151 0.27 15 0.236 Q6NXP2 R136W Polymorphism 0.543 0.760 0.02 53 0.673 Q6NXR0 D135N Polymorphism NA 0.928 0.00 45 0.732 Q6NXR4 E63G Polymorphism NA 0.341 NA 34 0.270 Q6NXR4 L425R Polymorphism NA 0.587 NA 11 0.425 Q6NY19 A485T Polymorphism NA 0.182 0.91 29 0.099 Q6NY19 R359H Polymorphism NA 0.248 0.14 37 0.188 Q6NYC8 G339R Polymorphism 0.202 0.187 0.12 -9 0.136 Q6NYC8 P356L Polymorphism 0.265 0.149 0.52 -1 0.071 Q6NYC8 R222G Polymorphism 0.328 0.183 0.42 19 0.089 Q6NZ36 P126S Polymorphism NA 0.079 0.91 0 0.046 Q6NZ63 I210T Polymorphism 0.183 0.446 0.13 -33 0.181 Q6NZ63 R166M Polymorphism 0.955 0.815 0.00 63 0.954 Q6NZI2 E193Q Polymorphism 0.705 0.190 0.06 14 0.235 Q6P050 V109L Polymorphism 0.283 0.524 NA 33 0.711 Q6P093 A186S Polymorphism 0.484 0.510 0.69 8 0.465 Q6P0N0 P347R Polymorphism NA 0.562 NA 46 0.754 Q6P0Q8 L69F Polymorphism NA 0.145 0.11 12 0.131 Q6P0Q8 D388E Polymorphism NA 0.179 1.00 -38 0.100 Q6P0Q8 I659M Polymorphism 0.079 0.326 0.57 -37 0.130 Q6P0Q8 R991L Polymorphism NA 0.058 0.35 30 0.085 Q6P0Q8 A1463T Polymorphism NA 0.061 0.02 17 0.105 Q6P0Q8 D1221E Polymorphism NA 0.170 1.00 -26 0.144 Q6P0Q8 G1468A Polymorphism NA 0.115 0.26 6 0.114 Q6P0Q8 G1703E Polymorphism NA 0.154 NA 30 0.058 Q6P0Q8 K1197R Polymorphism NA 0.477 0.34 23 0.422 Q6P0Q8 K1673R Polymorphism NA 0.138 0.39 20 0.041 Q6P0Q8 R1246L Polymorphism NA 0.575 0.00 49 0.722 Q6P0Q8 T1608I Polymorphism NA 0.144 0.01 32 0.293 Q6P158 S410F Polymorphism NA 0.308 0.00 41 0.538 Q6P179 L411R Polymorphism 0.900 0.838 0.01 33 0.860 Q6P179 P214L Polymorphism 0.997 0.877 0.00 40 0.920 Q6P1A2 F63L Polymorphism NA 0.292 0.65 -28 0.232 Q6P1A2 I217T Polymorphism 0.137 0.132 0.68 -18 0.113 Q6P1J6 M708V Polymorphism 0.203 0.066 0.65 -23 0.045 Q6P1J9 L64P Disease 0.798 0.910 0.00 44 0.872 Q6P1J9 L384P Polymorphism 0.765 0.793 0.32 27 0.835 Q6P1K2 Q75R Polymorphism NA 0.026 NA -13 0.014 Q6P1K2 M137I Polymorphism NA 0.212 NA 7 0.323 Q6P1L6 P520L Polymorphism 0.421 0.209 0.02 32 0.360 Q6P1M3 R45H Polymorphism NA 0.376 0.04 4 0.337 Q6P1M3 L490P Polymorphism 0.768 0.548 0.03 23 0.737 Q6P1M3 P488L Polymorphism 0.916 0.609 0.02 36 0.795 Q6P1M3 R748H Polymorphism 0.145 0.103 0.31 17 0.118 Q6P1M3 G1001S Polymorphism NA 0.114 0.50 -30 0.086 Q6P1N0 T339P Polymorphism NA 0.240 1.00 -49 0.122 Q6P1N0 T801M Polymorphism 0.261 0.126 0.20 -23 0.141 Q6P1Q9 V68I Polymorphism 0.220 0.092 0.18 0 0.175 Q6P1Q9 E169K Polymorphism NA 0.077 0.99 -14 0.084 Q6P1X5 S447T Polymorphism 0.158 0.198 0.44 17 0.093 Q6P280 V98L Polymorphism 0.072 0.200 0.72 0 0.131 Q6P2C0 L66H Polymorphism NA 0.141 NA -30 0.093 Q6P2C0 T352M Polymorphism NA 0.044 NA -14 0.073 Q6P2D8 K480E Polymorphism 0.194 0.130 0.23 32 0.101 Q6P2D8 T473R Polymorphism 0.086 0.148 0.00 56 0.156 Q6P2H3 R48H Polymorphism NA 0.265 0.00 60 0.466 Q6P2H3 A542T Polymorphism NA 0.037 0.57 -29 0.057 Q6P2M8 Q262H Polymorphism 0.301 0.065 0.12 -21 0.178 Q6P2P2 C747Y Polymorphism 0.686 0.493 0.00 52 0.594 Q6P2P2 S483G Polymorphism 0.084 0.085 0.00 -3 0.149 Q6P2Q9 K68E Polymorphism 0.249 0.834 0.00 34 0.662 Q6P2Q9 P874L Polymorphism 0.322 0.834 0.00 20 0.670 Q6P2Q9 R227H Polymorphism 0.234 0.217 0.03 -9 0.280 Q6P2Q9 F2304L Disease 0.350 0.808 0.06 31 0.712 Q6P2Q9 F2314L Disease 0.182 0.844 0.30 47 0.669 Q6P2Q9 H2309P Disease 0.736 0.925 0.00 35 0.859 Q6P2Q9 H2309R Disease 0.555 0.894 0.00 43 0.838 Q6P2Q9 P2301T Disease 0.662 0.704 0.00 44 0.860 Q6P2Q9 R2310G Disease 0.628 0.817 0.00 50 0.892 Q6P2Q9 R2310K Disease 0.325 0.716 0.00 46 0.770 Q6P2Q9 Y2334N Disease NA 0.187 0.00 0 0.359 Q6P387 T77S Polymorphism NA 0.144 0.00 0 0.173 Q6P387 P388S Polymorphism NA 0.293 0.00 51 0.408 Q6P3R8 K255Q Polymorphism 0.475 0.244 0.36 -31 0.289 Q6P3S1 V216M Polymorphism 0.296 0.292 0.03 19 0.413 Q6P3W7 T720S Polymorphism 0.245 0.184 NA 5 0.198 Q6P3X3 Y476C Polymorphism 0.951 0.774 0.01 40 0.892 Q6P474 L429F Polymorphism 0.188 0.052 0.02 26 0.056 Q6P474 L429R Polymorphism 0.297 0.187 1.00 -7 0.038 Q6P474 M209V Polymorphism NA 0.073 0.71 10 0.082 Q6P4F1 L59F Polymorphism 0.165 0.401 0.06 22 0.243 Q6P4F1 Y268H Polymorphism 0.200 0.521 0.50 0 0.216 Q6P4H8 V114A Polymorphism 0.381 0.702 0.07 31 0.632 Q6P4I2 R249H Polymorphism NA 0.046 0.21 -21 0.062 Q6P4Q7 G126R Polymorphism NA 0.123 0.00 13 0.125 Q6P4Q7 L324P Disease 0.979 0.956 0.01 55 0.947 Q6P4Q7 R236Q Disease 0.747 0.550 0.22 34 0.757 Q6P4Q7 S196P Disease 0.589 0.934 0.01 63 0.936 Q6P4Q7 S200Y Disease 0.721 0.856 0.00 59 0.909 Q6P531 R40W Polymorphism NA 0.065 0.02 17 0.060 Q6P587 D110N Polymorphism 0.147 0.085 0.52 -29 0.120 Q6P5S2 C308G Polymorphism 0.206 0.662 0.00 35 0.603 Q6P5W5 P84L Disease NA 0.106 0.02 7 0.111 Q6P5W5 R95C Disease NA 0.416 0.01 43 0.566 Q6P5W5 C309Y Disease NA 0.873 0.03 53 0.727 Q6P5W5 G330D Disease NA 0.772 0.00 10 0.744 Q6P5W5 G374R Disease NA 0.970 0.00 38 0.832 Q6P5W5 G526R Disease 0.376 0.919 0.00 69 0.923 Q6P5W5 G630R Disease 0.401 0.672 0.16 23 0.736 Q6P5W5 L372P Disease NA 0.974 0.00 47 0.880 Q6P5W5 L410P Disease 0.376 0.882 0.01 35 0.800 Q6P5W5 N106K Disease NA 0.082 0.05 27 0.100 Q6P5W5 P200L Disease NA 0.500 0.00 6 0.626 Q6P5W5 Q303H Disease NA 0.738 0.00 38 0.759 Q6P5W5 R251W Disease NA 0.355 0.01 34 0.267 Q6P5W5 T158M Polymorphism NA 0.087 0.01 17 0.100 Q6P5Z2 A180E Polymorphism NA 0.393 0.01 12 0.567 Q6P656 P284S Polymorphism NA 0.138 NA 12 0.129 Q6P6B1 R59H Polymorphism 0.097 0.040 0.26 -32 0.012 Q6P6B1 H287R Polymorphism 0.249 0.101 0.57 9 0.057 Q6P6B7 A128G Polymorphism 0.327 0.244 0.06 37 0.408 Q6P6B7 Q353R Polymorphism NA 0.278 0.26 3 0.311 Q6P7N7 F100S Polymorphism NA 0.394 0.00 38 0.195 Q6P9A1 G262S Polymorphism 0.401 0.768 0.26 -29 0.207 Q6P9A1 H110Q Polymorphism 0.092 0.479 1.00 -16 0.136 Q6P9B6 S443L Polymorphism 0.152 0.089 0.01 17 0.169 Q6P9F0 T394K Polymorphism NA 0.169 0.15 -37 0.136 Q6P9F5 K142Q Polymorphism 0.185 0.169 0.62 13 0.161 Q6P9F7 D288N Polymorphism NA 0.097 0.08 49 0.107 Q6P9F7 N689S Polymorphism 0.998 0.641 0.01 56 0.955 Q6P9F7 Q419K Polymorphism NA 0.425 0.38 46 0.364 Q6P9H5 V65I Polymorphism 0.103 0.083 0.39 16 0.170 Q6P9H5 G171S Polymorphism 0.162 0.285 0.70 -16 0.247 Q6PB30 K62R Polymorphism NA 0.050 NA 9 0.021 Q6PCD5 T90N Polymorphism 0.068 0.041 0.75 -9 0.043 Q6PCE3 L14P Polymorphism NA 0.154 0.01 50 0.113 Q6PD74 I132L Polymorphism NA 0.201 NA -28 0.182 Q6PEW0 T295A Polymorphism NA 0.092 1.00 -5 0.034 Q6PEW0 V240I Polymorphism 0.154 0.137 1.00 -7 0.115 Q6PEW1 L179I Polymorphism 0.166 0.341 0.23 -16 0.204 Q6PEW1 R214G Polymorphism 0.230 0.274 0.14 10 0.250 Q6PEX3 S26Y Polymorphism NA 0.160 0.05 48 0.187 Q6PEY0 T20I Polymorphism 0.073 0.341 1.00 -54 0.027 Q6PEY0 F206L Polymorphism 0.111 0.137 0.67 -33 0.112 Q6PEY2 A449E Polymorphism 0.136 0.163 1.00 -21 0.079 Q6PEY2 S101N Polymorphism NA 0.060 1.00 2 0.016 Q6PEY2 S162G Polymorphism 0.212 0.114 0.63 -49 0.116 Q6PEY2 W402R Polymorphism NA 0.352 0.94 -4 0.013 Q6PEZ8 R44W Polymorphism NA 0.382 0.09 49 0.593 Q6PF04 I135R Polymorphism 0.165 0.309 0.63 11 0.237 Q6PF04 S163F Polymorphism 0.135 0.476 0.02 -6 0.270 Q6PF05 K247N Polymorphism NA 0.446 0.02 44 0.582 Q6PF05 T150M Polymorphism NA 0.115 0.06 28 0.134 Q6PG37 T486S Polymorphism 0.318 0.219 0.30 -17 0.274 Q6PGP7 L437V Polymorphism NA 0.088 0.30 -37 0.140 Q6PGP7 R1296S Polymorphism 0.199 0.219 NA 47 0.294 Q6PGQ1 I4T Polymorphism NA 0.456 0.22 2 0.283 Q6PGQ7 S210L Polymorphism 0.649 0.076 0.11 -13 0.094 Q6PGQ7 S308F Polymorphism 0.498 0.155 0.01 35 0.181 Q6PHR2 R101H Polymorphism 0.215 0.235 0.57 -35 0.238 Q6PHW0 I116T Disease 0.541 0.922 0.01 29 0.836 Q6PHW0 L260P Polymorphism 0.382 0.925 0.00 41 0.798 Q6PHW0 R101W Disease 0.757 0.762 0.00 68 0.910 Q6PI26 S489N Polymorphism 0.121 0.031 0.77 -27 0.016 Q6PI47 A413V Polymorphism NA 0.044 NA 8 0.048 Q6PI47 C390S Polymorphism NA 0.039 NA -12 0.020 Q6PI48 S45G Disease NA 0.206 0.05 -19 0.209 Q6PI48 C152F Disease 0.570 0.800 0.01 46 0.822 Q6PI48 D560V Disease 0.494 0.585 0.01 -8 0.422 Q6PI48 L613F Disease 0.727 0.748 0.05 33 0.828 Q6PI48 L626Q Disease 0.915 0.742 0.00 40 0.865 Q6PI48 L626V Disease 0.716 0.663 0.00 40 0.810 Q6PI48 Q184K Disease 0.203 0.458 0.17 -5 0.274 Q6PI48 Q248K Disease 0.904 0.924 0.00 45 0.824 Q6PI48 R179H Disease 0.959 0.851 0.00 66 0.924 Q6PI48 R263Q Disease 0.668 0.610 0.00 50 0.831 Q6PI48 Y629C Disease 0.890 0.634 0.00 50 0.884 Q6PI73 L69W Polymorphism 0.175 0.349 0.10 -53 0.220 Q6PI73 G149R Polymorphism 0.138 0.230 0.36 39 0.252 Q6PI73 P288R Polymorphism NA 0.190 1.00 13 0.281 Q6PI73 Y400H Polymorphism 0.188 0.469 0.19 0 0.240 Q6PI77 C318R Polymorphism 0.629 0.137 0.23 55 0.378 Q6PID6 L69M Polymorphism 0.640 0.125 0.21 60 0.263 Q6PID8 S2L Polymorphism NA 0.149 0.00 -27 0.136 Q6PIF6 E1647D Polymorphism 0.203 0.438 0.62 3 0.253 Q6PIJ6 S592P Polymorphism NA 0.042 NA -42 0.017 Q6PIU2 K71Q Polymorphism 0.295 0.208 0.66 -23 0.249 Q6PIU2 V19F Polymorphism 0.588 0.381 0.37 -1 0.472 Q6PIU2 L343M Polymorphism 0.385 0.144 0.03 9 0.239 Q6PIW4 V137M Polymorphism NA 0.141 0.05 32 0.158 Q6PJ21 S171L Polymorphism 0.612 0.521 0.09 25 0.705 Q6PJ69 G364R Polymorphism 0.362 0.655 0.56 43 0.390 Q6PJ69 G366S Polymorphism 0.182 0.437 0.73 -16 0.161 Q6PJI9 P201T Polymorphism 0.487 0.775 0.13 35 0.815 Q6PJP8 E59D Polymorphism NA 0.149 0.37 0 0.119 Q6PJP8 G71D Polymorphism NA 0.083 NA -13 0.032 Q6PJP8 K58E Polymorphism NA 0.107 0.13 14 0.110 Q6PJP8 I859F Polymorphism 0.573 0.459 0.05 26 0.642 Q6PJP8 P287L Polymorphism NA 0.266 1.00 1 0.103 Q6PJW8 R399C Polymorphism NA 0.061 NA 0 0.030 Q6PK04 H127Q Polymorphism 0.102 0.036 NA -37 0.024 Q6PK18 P272R Polymorphism 0.125 0.586 0.00 50 0.634 Q6PKC3 V783L Polymorphism NA 0.026 0.49 -13 0.042 Q6PKH6 L17M Polymorphism 0.027 0.144 0.46 -77 0.053 Q6PML9 L353S Polymorphism 0.803 0.508 0.08 -30 0.738 Q6PRD1 Q1176E Polymorphism NA 0.220 NA 18 0.183 Q6PRD7 K55E Polymorphism NA 0.251 NA 36 0.019 Q6PXP3 V135I Polymorphism 0.083 0.067 1.00 -31 0.026 Q6Q759 R143Q Polymorphism NA 0.297 NA 40 0.258 Q6Q759 T1253P Polymorphism 0.323 0.198 NA 2 0.215 Q6Q788 D37E Polymorphism 0.095 0.224 0.89 20 0.170 Q6Q788 G185C Polymorphism 0.593 0.300 0.02 20 0.571 Q6Q788 V153M Polymorphism 0.120 0.038 0.28 -25 0.043 Q6QHC5 A57T Polymorphism 0.168 0.104 0.07 -46 0.158 Q6QNK2 V508M Polymorphism NA 0.213 0.07 44 0.388 Q6QNY1 S13R Polymorphism NA 0.074 1.00 8 0.032 Q6R327 S837F Polymorphism 0.178 0.235 0.26 25 0.081 Q6R6M4 K438R Polymorphism NA 0.137 0.10 -14 0.084 Q6RI45 K1596E Disease 0.251 0.158 0.03 8 0.194 Q6RUI8 V7I Polymorphism NA 0.108 NA 15 0.052 Q6RUI8 G104E Polymorphism NA 0.347 NA 54 0.125 Q6RW13 A143V Polymorphism NA 0.106 0.00 30 0.138 Q6S5H4 C64W Polymorphism NA 0.270 1.00 28 0.063 Q6S5H4 C68R Polymorphism NA 0.542 0.00 46 0.477 Q6S5H4 H30D Polymorphism NA 0.278 0.02 68 0.342 Q6S5H4 M43V Polymorphism NA 0.108 1.00 -8 0.016 Q6S5H4 N88D Polymorphism NA 0.050 1.00 5 0.046 Q6S5L8 N52D Polymorphism NA 0.068 0.79 -16 0.067 Q6S5L8 K244E Polymorphism 0.067 0.746 0.08 42 0.368 Q6S5L8 Q400H Polymorphism 0.534 0.183 0.17 43 0.270 Q6S9Z5 R173H Polymorphism NA 0.867 0.00 61 0.880 Q6SA08 H33Y Polymorphism NA 0.720 0.09 14 0.629 Q6SA08 Y89C Polymorphism 0.915 0.761 0.00 63 0.914 Q6SA08 Q196R Polymorphism 0.201 0.603 0.51 4 0.256 Q6SA08 T327M Polymorphism NA 0.084 0.02 31 0.139 Q6SA08 V145M Polymorphism 0.742 0.603 0.00 29 0.803 Q6SJ93 P731A Polymorphism NA 0.043 NA 18 0.050 Q6STE5 P170S Polymorphism NA 0.306 0.60 -33 0.249 Q6T423 G448A Polymorphism 0.091 0.257 0.99 -34 0.138 Q6T423 S250G Polymorphism 0.092 0.055 0.83 -42 0.055 Q6TDU7 R33S Polymorphism 0.483 0.258 0.01 34 0.244 Q6TFL3 C821Y Polymorphism NA 0.416 NA 35 0.213 Q6TFL3 N495I Polymorphism NA 0.056 0.07 18 0.055 Q6TFL3 S121T Polymorphism NA 0.061 0.15 8 0.072 Q6U949 F125V Polymorphism NA 0.139 NA 33 0.049 Q6U949 S106I Polymorphism NA 0.194 NA 26 0.024 Q6UB98 K906R Polymorphism NA 0.204 0.01 21 0.202 Q6UB98 P277A Polymorphism 0.213 0.276 0.13 28 0.352 Q6UB98 S818N Polymorphism NA 0.100 0.01 -38 0.052 Q6UB98 T531S Polymorphism NA 0.133 0.01 12 0.037 Q6UDR6 G73S Polymorphism 0.593 0.457 0.00 63 0.870 Q6UE05 A70D Polymorphism NA 0.294 NA 50 0.285 Q6ULP2 N550S Polymorphism 0.174 0.028 0.96 -40 0.027 Q6UUV7 S72N Polymorphism 0.054 0.137 0.57 -10 0.115 Q6UUV9 T286A Polymorphism 0.592 0.716 0.13 -10 0.571 Q6UUV9 T328A Polymorphism 0.096 0.150 0.47 20 0.121 Q6UUV9 V311I Polymorphism 0.085 0.088 0.20 20 0.122 Q6UVM3 K429N Polymorphism 0.614 0.771 0.00 44 0.658 Q6UVW9 G136D Polymorphism 0.103 0.535 0.60 34 0.166 Q6UVY6 E488Q Polymorphism 0.366 0.103 0.71 7 0.143 Q6UW02 S97L Polymorphism 0.065 0.487 0.79 12 0.180 Q6UW02 L346F Polymorphism 0.123 0.810 0.15 -4 0.198 Q6UW49 L133F Polymorphism NA 0.195 0.00 32 0.228 Q6UW56 A209S Polymorphism NA 0.073 NA -24 0.054 Q6UW63 I114V Polymorphism 0.181 0.028 1.00 2 0.067 Q6UWE0 N318D Polymorphism 0.058 0.050 0.03 -14 0.021 Q6UWF7 Y398H Polymorphism 0.221 0.132 1.00 14 0.054 Q6UWH4 G432S Polymorphism NA 0.861 0.00 44 0.837 Q6UWJ1 A445T Polymorphism 0.222 0.776 0.26 -12 0.363 Q6UWL2 Q201E Polymorphism NA 0.208 0.61 30 0.262 Q6UWL6 A170T Polymorphism NA 0.216 0.40 38 0.292 Q6UWM7 A240T Polymorphism 0.334 0.681 0.06 0 0.193 Q6UWM7 T212M Polymorphism 0.424 0.401 0.23 -7 0.382 Q6UWN0 T184S Polymorphism NA 0.145 0.84 -8 0.099 Q6UWN5 A90P Polymorphism 0.133 0.132 0.12 28 0.068 Q6UWN5 N167S Polymorphism 0.084 0.157 0.43 24 0.115 Q6UWP7 I290V Polymorphism 0.309 0.225 0.68 -5 0.268 Q6UWR7 S419G Polymorphism 0.056 0.051 0.55 -8 0.077 Q6UWT4 F18I Polymorphism NA 0.118 NA -63 0.012 Q6UWV2 D228V Polymorphism 0.270 0.421 0.00 43 0.440 Q6UWV2 M155V Polymorphism 0.128 0.037 0.76 36 0.061 Q6UWV2 V168G Polymorphism 0.741 0.471 0.01 -4 0.520 Q6UWV6 L4P Polymorphism NA 0.582 0.22 21 0.589 Q6UWW0 K164E Polymorphism 0.060 0.094 1.00 -8 0.063 Q6UWW0 S152A Polymorphism 0.156 0.168 0.05 -29 0.083 Q6UWX4 V241M Polymorphism 0.702 0.837 0.01 12 0.809 Q6UWY5 A259T Polymorphism 0.319 0.438 0.44 26 0.368 Q6UWZ7 A239T Polymorphism NA 0.067 0.85 -51 0.086 Q6UX07 L336Q Polymorphism NA 0.104 0.40 26 0.060 Q6UX07 R191Q Polymorphism NA 0.162 0.66 30 0.257 Q6UX15 E66K Polymorphism 0.326 0.815 0.07 43 0.696 Q6UX39 N45S Polymorphism NA 0.192 NA 42 0.065 Q6UX41 E229K Polymorphism 0.158 0.311 0.93 48 0.243 Q6UX73 G215A Polymorphism NA 0.140 NA 16 0.133 Q6UX73 L296S Polymorphism NA 0.126 0.03 -9 0.156 Q6UXA7 V5M Polymorphism 0.310 0.030 0.06 -46 0.025 Q6UXA7 A83P Polymorphism 0.105 0.038 1.00 -42 0.005 Q6UXA7 V81A Polymorphism 0.096 0.055 1.00 -29 0.021 Q6UXA7 K165E Polymorphism 0.077 0.020 1.00 -25 0.015 Q6UXB0 C52R Polymorphism NA 0.198 NA 49 0.062 Q6UXB3 A7V Polymorphism NA 0.053 0.57 -71 0.020 Q6UXB8 T50P Polymorphism 0.363 0.582 1.00 -32 0.382 Q6UXC1 W987G Polymorphism 0.088 0.410 0.58 45 0.400 Q6UXD7 S170P Polymorphism 0.821 0.772 0.23 62 0.923 Q6UXF1 P84L Polymorphism NA 0.057 0.07 34 0.063 Q6UXG2 L1009P Polymorphism NA 0.084 NA 34 0.026 Q6UXG3 D221N Polymorphism 0.045 0.044 0.68 29 0.072 Q6UXG8 G511R Polymorphism NA 0.141 0.37 20 0.207 Q6UXH0 R147Q Polymorphism 0.054 0.038 0.43 -30 0.019 Q6UXH1 D182E Polymorphism 0.135 0.274 1.00 -18 0.209 Q6UXI9 M476T Polymorphism 0.371 0.147 1.00 17 0.218 Q6UXI9 Q159H Polymorphism 0.145 0.334 0.12 18 0.254 Q6UXN2 T146K Polymorphism 0.421 0.071 0.92 13 0.062 Q6UXN8 A107G Polymorphism 0.070 0.113 0.39 13 0.081 Q6UXP3 L82P Polymorphism 0.747 0.712 0.01 49 0.878 Q6UXU6 S90T Polymorphism NA 0.077 NA -32 0.037 Q6UXV0 S387P Polymorphism NA 0.018 NA 54 0.042 Q6UXV1 R139C Polymorphism NA 0.085 0.18 38 0.069 Q6UXX5 G387R Polymorphism NA 0.768 0.35 42 0.637 Q6UXZ3 S6A Polymorphism NA 0.069 1.00 -39 0.013 Q6UY01 L322F Polymorphism 0.121 0.507 0.08 4 0.570 Q6UY09 C512R Polymorphism NA 0.216 0.26 61 0.148 Q6UY09 I127V Polymorphism NA 0.091 0.27 -16 0.143 Q6UY09 R113H Polymorphism NA 0.638 0.00 48 0.643 Q6UY09 S355L Polymorphism NA 0.480 0.90 -6 0.402 Q6UY11 G301R Polymorphism 0.618 0.468 0.16 45 0.618 Q6UYE1 A83V Polymorphism NA 0.068 NA 17 0.056 Q6V0I7 A807V Polymorphism NA 0.514 0.29 26 0.421 Q6V0I7 Q453L Polymorphism NA 0.493 0.26 27 0.384 Q6V0I7 E4374K Polymorphism NA 0.338 0.03 30 0.346 Q6V0I7 S3873N Polymorphism 0.220 0.054 0.78 3 0.070 Q6V0L0 R245Q Polymorphism 0.253 0.418 0.57 -3 0.232 Q6V1P9 H174R Polymorphism NA 0.184 0.63 35 0.086 Q6V1P9 S344L Polymorphism NA 0.479 0.65 -14 0.235 Q6V1P9 S1205L Polymorphism NA 0.192 0.06 29 0.396 Q6V1P9 T1480R Polymorphism 0.191 0.152 0.61 -34 0.113 Q6V702 T138M Polymorphism NA 0.364 0.02 13 0.434 Q6V9R5 K205E Polymorphism 0.079 0.199 0.95 -1 0.152 Q6VVB1 C26S Disease 0.434 0.687 0.00 50 0.770 Q6VVB1 C68Y Disease 0.722 0.796 0.16 59 0.893 Q6VVB1 E67Q Disease 0.416 0.355 0.00 37 0.326 Q6VVB1 F33S Disease 0.554 0.346 0.00 56 0.390 Q6VVB1 L87P Disease 0.725 0.644 0.04 42 0.710 Q6VVB1 P69A Disease 0.442 0.285 0.14 45 0.393 Q6VVB1 S22R Disease NA 0.209 0.00 14 0.089 Q6VVB1 C160R Disease 0.382 0.264 0.12 57 0.439 Q6VVB1 D146N Disease 0.389 0.347 0.42 52 0.489 Q6VVB1 D233A Disease 0.438 0.716 0.03 61 0.862 Q6VVB1 D245N Disease 0.389 0.607 0.50 49 0.743 Q6VVB1 D308A Disease 0.438 0.187 0.17 55 0.340 Q6VVB1 I153M Disease 0.416 0.447 0.01 30 0.420 Q6VVB1 I198N Disease 0.587 0.585 0.00 40 0.719 Q6VVB1 L126P Disease 0.725 0.852 0.01 38 0.852 Q6VVB1 L279P Disease 0.725 0.585 0.20 44 0.702 Q6VVB1 P264H Disease 0.767 0.662 0.00 67 0.930 Q6VVB1 Q302P Disease 0.572 0.632 0.20 28 0.694 Q6VVB1 R253K Disease 0.243 0.084 0.29 0 0.070 Q6VVB1 W219R Disease 0.651 0.818 0.85 70 0.621 Q6VY07 F302L Polymorphism NA 0.364 0.74 -33 0.249 Q6W2J9 P85L Disease NA 0.190 NA 35 0.197 Q6W3E5 H383Y Polymorphism 0.450 0.387 0.28 55 0.378 Q6W3E5 I390V Polymorphism 0.508 0.044 0.47 -4 0.103 Q6W5P4 I315T Polymorphism 0.629 0.233 0.60 41 0.559 Q6W5P4 N107I Polymorphism 0.075 0.211 0.94 -17 0.112 Q6W5P4 Q344R Polymorphism 0.075 0.127 0.37 15 0.099 Q6W5P4 R122Q Polymorphism 0.393 0.652 0.02 46 0.647 Q6W5P4 S143G Polymorphism 0.541 0.371 0.02 20 0.607 Q6WKZ4 A768V Polymorphism 0.488 0.051 NA -19 0.006 Q6WKZ4 V651A Polymorphism NA 0.035 NA -25 0.003 Q6WN34 P335L Polymorphism 0.605 0.271 0.21 1 0.458 Q6WRI0 P571S Polymorphism NA 0.657 0.55 43 0.600 Q6WRI0 H2579Y Polymorphism NA 0.634 1.00 58 0.269 Q6WRI0 R2476W Polymorphism 0.759 0.318 0.19 57 0.728 Q6WRI0 Y1875H Polymorphism 0.102 0.263 0.97 16 0.129 Q6X4T0 P86S Polymorphism NA 0.038 NA -17 0.026 Q6X4U4 Q189H Polymorphism 0.105 0.045 0.06 16 0.029 Q6X4W1 L511V Polymorphism NA 0.329 NA 18 0.475 Q6X4W1 T480A Disease NA 0.162 NA -19 0.142 Q6X784 P68A Polymorphism 0.775 0.469 0.00 45 0.741 Q6X784 Q335E Polymorphism NA 0.084 NA 8 0.042 Q6X9E4 P6L Polymorphism NA 0.562 NA 48 0.726 Q6XPR3 S320G Polymorphism NA 0.119 0.55 -36 0.109 Q6XPS3 V367I Polymorphism 0.091 0.233 0.37 1 0.220 Q6XUX3 L432V Polymorphism 0.291 0.393 0.00 8 0.267 Q6XYB7 S158F Polymorphism 0.250 0.452 0.07 25 0.521 Q6XZB0 D444E Polymorphism 0.161 0.174 1.00 0 0.047 Q6XZB0 G364E Polymorphism 0.196 0.718 0.65 30 0.416 Q6XZF7 N373K Polymorphism NA 0.105 0.38 25 0.071 Q6XZF7 C1413W Polymorphism 0.868 0.184 0.00 54 0.520 Q6Y7W6 D606E Disease 0.519 0.316 0.02 14 0.584 Q6Y7W6 I278V Disease 0.107 0.147 0.48 -24 0.098 Q6Y7W6 N457T Disease 0.090 0.205 0.03 7 0.159 Q6Y7W6 P423L Polymorphism 0.163 0.288 0.00 24 0.302 Q6Y7W6 P460T Polymorphism 0.069 0.341 0.50 19 0.199 Q6Y7W6 S335T Disease 0.376 0.203 0.00 -12 0.325 Q6Y7W6 T112A Disease NA 0.218 1.00 -5 0.151 Q6Y7W6 H1171R Polymorphism 0.309 0.653 0.00 -53 0.466 Q6Y7W6 V1242I Disease 0.103 0.108 0.18 13 0.082 Q6YBV0 L429I Polymorphism 0.820 0.451 0.16 -22 0.605 Q6YHK3 N797S Polymorphism 0.078 0.114 0.48 -10 0.081 Q6YHK3 Y703S Polymorphism 0.060 0.271 1.00 -18 0.131 Q6YHK3 H1296R Polymorphism 0.408 0.194 0.74 -12 0.209 Q6YHK3 T1241M Polymorphism 0.068 0.389 0.02 -28 0.296 Q6YHK3 V1009M Polymorphism 0.459 0.557 0.17 -20 0.462 Q6YHU6 C1668R Polymorphism 0.463 0.482 0.06 55 0.317 Q6ZMB5 S390G Polymorphism NA 0.083 0.40 3 0.103 Q6ZMC9 F273L Polymorphism NA 0.187 1.00 -47 0.064 Q6ZMD2 A330S Polymorphism 0.439 0.202 1.00 -15 0.257 Q6ZMI3 S141N Polymorphism NA 0.379 0.06 -23 0.410 Q6ZMN8 A91P Polymorphism NA 0.229 0.39 -19 0.071 Q6ZMQ8 S815R Polymorphism NA 0.131 0.05 39 0.113 Q6ZMQ8 T118M Polymorphism NA 0.112 0.22 5 0.226 Q6ZMQ8 A1332T Polymorphism NA 0.163 0.00 28 0.266 Q6ZMQ8 E1160K Polymorphism NA 0.092 0.00 20 0.158 Q6ZMQ8 P1192S Polymorphism NA 0.051 0.01 15 0.111 Q6ZMR5 R293Q Polymorphism 0.058 0.343 0.28 40 0.434 Q6ZMT4 D392Y Polymorphism 0.709 0.409 0.01 21 0.619 Q6ZMT4 R644S Polymorphism 0.275 0.057 0.04 -18 0.061 Q6ZMU1 D251G Polymorphism 0.405 0.178 1.00 14 0.087 Q6ZMV8 G365E Polymorphism 0.900 0.547 1.00 -24 0.301 Q6ZMV9 W719R Polymorphism NA 0.067 NA 33 0.040 Q6ZMW2 R130P Polymorphism NA 0.714 0.32 17 0.458 Q6ZMW2 R165H Polymorphism NA 0.722 0.19 -22 0.338 Q6ZMY3 T109A Polymorphism NA 0.035 NA 19 0.027 Q6ZMY9 P6L Polymorphism NA 0.170 0.72 -4 0.125 Q6ZMZ3 R864H Polymorphism 0.057 0.053 0.18 -43 0.052 Q6ZN06 R231K Polymorphism 0.379 0.579 0.97 -25 0.216 Q6ZN06 Y192C Polymorphism 0.534 0.651 1.00 44 0.366 Q6ZN06 Y439F Polymorphism 0.590 0.558 0.22 28 0.557 Q6ZN16 D226H Polymorphism NA 0.428 0.01 8 0.437 Q6ZN16 G838S Polymorphism 0.795 0.900 0.00 55 0.911 Q6ZN16 S199N Polymorphism NA 0.177 0.00 0 0.253 Q6ZN16 N1029H Polymorphism 0.113 0.279 0.00 11 0.230 Q6ZN16 Q1251E Polymorphism NA 0.249 0.08 17 0.402 Q6ZN28 L31V Polymorphism NA 0.023 0.87 9 0.022 Q6ZN28 R804T Polymorphism NA 0.707 0.00 62 0.868 Q6ZN30 L550V Polymorphism 0.146 0.102 0.47 14 0.075 Q6ZN30 T782A Polymorphism 0.164 0.101 0.66 12 0.055 Q6ZN32 G263A Polymorphism NA 0.149 0.60 28 0.136 Q6ZN32 M318V Polymorphism NA 0.133 0.10 16 0.043 Q6ZN32 R151W Polymorphism 0.812 0.246 0.05 50 0.572 Q6ZN55 T711S Polymorphism NA 0.408 0.90 -18 0.221 Q6ZN57 R142G Polymorphism 0.464 0.423 0.40 52 0.478 Q6ZN66 L344F Polymorphism 0.330 0.424 0.17 -24 0.282 Q6ZN66 T278I Polymorphism 0.280 0.329 0.07 9 0.346 Q6ZN68 N333I Polymorphism NA 0.343 0.02 30 0.474 Q6ZN79 K142Q Polymorphism 0.126 0.270 0.00 44 0.362 Q6ZN79 R134C Polymorphism 0.448 0.284 0.02 -11 0.474 Q6ZN79 T126A Polymorphism 0.072 0.256 0.34 -8 0.181 Q6ZN90 A186T Polymorphism 0.271 0.091 0.07 16 0.209 Q6ZN90 L291F Polymorphism 0.765 0.862 0.00 -6 0.761 Q6ZN90 R396K Polymorphism 0.304 0.243 0.29 -42 0.137 Q6ZNA1 M219I Polymorphism NA 0.333 0.15 7 0.192 Q6ZNA1 N809S Polymorphism 0.294 0.464 0.58 -10 0.267 Q6ZNA4 A718T Polymorphism 0.353 0.261 0.02 33 0.180 Q6ZNB6 P246L Polymorphism 0.481 0.580 0.18 27 0.507 Q6ZNG1 T13R Polymorphism 0.245 0.233 0.76 0 0.201 Q6ZNI0 N425H Polymorphism 0.019 0.152 0.00 42 0.157 Q6ZNJ1 R447H Polymorphism NA 0.098 0.00 -44 0.177 Q6ZNJ1 R511G Polymorphism NA 0.204 0.08 44 0.357 Q6ZNJ1 E2747K Polymorphism 0.353 0.253 0.00 39 0.414 Q6ZNJ1 S2054F Polymorphism NA 0.382 0.00 30 0.427 Q6ZNL6 A828T Polymorphism NA 0.114 0.11 32 0.120 Q6ZNQ3 T64I Polymorphism NA 0.260 0.27 -19 0.194 Q6ZP01 D51H Polymorphism NA 0.158 0.04 53 0.128 Q6ZP01 D52H Polymorphism NA 0.125 0.19 45 0.120 Q6ZP82 N595S Polymorphism NA 0.108 NA -10 0.056 Q6ZP82 R253W Polymorphism NA 0.143 0.02 26 0.104 Q6ZP82 R360W Polymorphism NA 0.412 0.02 43 0.304 Q6ZQR6 S57R Polymorphism NA 0.309 NA 32 0.061 Q6ZQX7 E56K Polymorphism NA 0.239 NA 2 0.173 Q6ZQY2 G3R Polymorphism NA 0.233 0.11 23 0.144 Q6ZQY2 R77C Polymorphism NA 0.905 0.04 34 0.856 Q6ZR08 V32A Polymorphism NA 0.301 NA -11 0.126 Q6ZR08 D224E Polymorphism NA 0.402 0.54 3 0.286 Q6ZR08 T467P Polymorphism NA 0.716 0.13 47 0.464 Q6ZR08 D1549N Polymorphism 0.276 0.190 0.44 26 0.223 Q6ZR08 G2893S Polymorphism 0.575 0.192 0.00 12 0.354 Q6ZR08 Y1704H Polymorphism 0.220 0.508 0.53 -32 0.207 Q6ZR08 Y2740F Polymorphism 0.355 0.783 0.00 -19 0.532 Q6ZR37 M212T Polymorphism NA 0.132 0.50 -10 0.163 Q6ZR62 L27P Polymorphism NA 0.075 0.25 -6 0.009 Q6ZRC1 R86W Polymorphism NA 0.156 NA 14 0.104 Q6ZRC1 V199M Polymorphism NA 0.040 NA 20 0.031 Q6ZRF7 E14K Polymorphism NA 0.070 1.00 32 0.024 Q6ZRF8 A421T Polymorphism 0.276 0.037 0.48 -29 0.054 Q6ZRF8 N573S Polymorphism 0.169 0.061 0.58 -27 0.006 Q6ZRH7 L29P Polymorphism NA 0.891 NA 15 0.536 Q6ZRH7 M1137T Polymorphism NA 0.061 NA 47 0.051 Q6ZRI0 A919T Polymorphism 0.230 0.109 0.44 7 0.171 Q6ZRI0 S692P Polymorphism 0.318 0.232 0.30 24 0.203 Q6ZRI0 T659M Polymorphism 0.460 0.209 0.10 29 0.385 Q6ZRI0 A1112V Polymorphism 0.119 0.667 0.03 42 0.284 Q6ZRI0 R1075Q Polymorphism 0.380 0.746 0.49 33 0.453 Q6ZRI0 R2750Q Polymorphism NA 0.120 0.52 0 0.133 Q6ZRI0 T1947M Polymorphism NA 0.076 0.04 39 0.102 Q6ZRI0 W2909S Polymorphism NA 0.114 0.88 46 0.148 Q6ZRI6 A119P Polymorphism NA 0.121 NA 16 0.115 Q6ZRM9 F205L Polymorphism NA 0.078 NA -6 0.023 Q6ZRN7 A108G Polymorphism NA 0.104 NA 14 0.021 Q6ZRQ5 N419D Polymorphism NA 0.194 0.34 44 0.211 Q6ZRQ5 T564M Polymorphism NA 0.259 0.09 44 0.418 Q6ZRS4 A32D Polymorphism NA 0.336 0.00 31 0.243 Q6ZS11 P288L Polymorphism NA 0.784 0.01 37 0.707 Q6ZS81 S214P Polymorphism NA 0.199 0.01 -27 0.304 Q6ZS81 S944F Polymorphism NA 0.122 0.96 26 0.128 Q6ZS82 A96S Polymorphism 0.168 0.146 0.48 -13 0.088 Q6ZSB9 Y320S Polymorphism NA 0.112 0.42 -1 0.091 Q6ZSH3 E145D Polymorphism NA 0.200 NA 6 0.041 Q6ZSI9 C287R Polymorphism 0.061 0.745 0.41 -15 0.148 Q6ZSS7 R205G Polymorphism NA 0.167 0.31 40 0.113 Q6ZT07 E7K Polymorphism NA 0.775 0.00 41 0.768 Q6ZT77 C148Y Polymorphism 0.926 0.313 1.00 6 0.000 Q6ZT83 R88W Polymorphism NA 0.605 NA 30 0.404 Q6ZTK2 Q183H Polymorphism NA 0.017 NA -24 0.030 Q6ZTK2 V275A Polymorphism NA 0.046 NA 4 0.021 Q6ZTK2 V345I Polymorphism NA 0.210 NA 15 0.174 Q6ZTK2 W419R Polymorphism NA 0.191 NA 35 0.061 Q6ZTQ4 Q61H Polymorphism 0.214 0.335 0.04 45 0.410 Q6ZTQ4 C529Y Polymorphism 0.202 0.447 1.00 24 0.034 Q6ZTR5 C345R Polymorphism NA 0.279 NA 36 0.244 Q6ZTR5 H634Y Polymorphism NA 0.279 NA 47 0.425 Q6ZTR5 V236M Polymorphism NA 0.106 NA 42 0.111 Q6ZTR7 E22K Polymorphism 0.234 0.901 0.00 47 0.736 Q6ZTY8 G387S Polymorphism NA 0.391 NA 32 0.275 Q6ZU35 R710Q Polymorphism NA 0.385 0.01 20 0.199 Q6ZU64 K806M Polymorphism NA 0.027 NA -10 0.020 Q6ZU64 V672I Polymorphism NA 0.092 NA 16 0.108 Q6ZU64 N1858S Polymorphism NA 0.104 NA 7 0.035 Q6ZU65 P1308A Polymorphism NA 0.152 0.44 31 0.173 Q6ZU80 R16L Polymorphism NA 0.422 NA 5 0.260 Q6ZU80 H732R Polymorphism NA 0.165 0.66 34 0.148 Q6ZUB1 D682E Polymorphism 0.274 0.041 0.73 -7 0.045 Q6ZUB1 D704E Polymorphism 0.358 0.057 0.74 -12 0.092 Q6ZUB1 G700R Polymorphism 0.365 0.329 0.39 36 0.262 Q6ZUB1 K586E Polymorphism 0.297 0.300 0.05 2 0.460 Q6ZUB1 T335P Polymorphism 0.372 0.051 0.71 11 0.034 Q6ZUB1 V409M Polymorphism 0.252 0.075 0.22 -2 0.061 Q6ZUB1 D1202G Polymorphism 0.241 0.141 0.55 7 0.208 Q6ZUB1 R1350H Polymorphism 0.336 0.076 0.14 -44 0.055 Q6ZUB1 V1019E Polymorphism 0.225 0.079 0.34 28 0.034 Q6ZUJ4 E110K Polymorphism NA 0.023 NA -8 0.027 Q6ZUJ8 A83S Polymorphism NA 0.050 0.80 -1 0.035 Q6ZUJ8 E551K Polymorphism 0.357 0.322 0.00 23 0.189 Q6ZUJ8 K638R Polymorphism 0.261 0.136 0.00 -15 0.064 Q6ZUT3 G24E Disease 0.996 0.919 0.02 76 0.943 Q6ZUT3 G24R Disease 0.996 0.936 0.02 77 0.944 Q6ZUT3 A226T Disease 0.561 0.615 0.29 31 0.582 Q6ZUT3 A266P Disease 0.649 0.821 0.32 26 0.825 Q6ZUT3 C271Y Disease 0.990 0.954 0.01 61 0.949 Q6ZUT3 L142R Disease 0.950 0.914 0.01 68 0.927 Q6ZUT3 L231V Disease 0.455 0.730 0.13 17 0.487 Q6ZUT3 N221D Disease 0.865 0.811 0.02 44 0.868 Q6ZUT3 R468H Polymorphism NA 0.137 0.01 37 0.152 Q6ZUT3 S281L Polymorphism 0.615 0.569 0.71 5 0.434 Q6ZUT3 S340L Disease 0.634 0.246 0.03 10 0.534 Q6ZUT3 Y301C Disease 0.996 0.896 0.01 38 0.939 Q6ZUX3 G944V Polymorphism NA 0.597 0.00 -7 0.461 Q6ZUX3 T941A Polymorphism NA 0.096 0.11 -34 0.055 Q6ZUX3 V535A Polymorphism NA 0.079 0.60 -38 0.090 Q6ZUX7 I102V Polymorphism 0.179 0.236 0.92 -32 0.170 Q6ZV29 E368D Polymorphism NA 0.108 0.60 -38 0.139 Q6ZV29 G286S Polymorphism NA 0.476 0.04 -17 0.517 Q6ZV29 P908L Polymorphism 0.135 0.370 0.21 0 0.289 Q6ZV29 R323Q Polymorphism NA 0.087 0.69 -12 0.076 Q6ZV29 V803A Polymorphism NA 0.149 1.00 2 0.082 Q6ZV29 V824M Polymorphism NA 0.433 0.01 26 0.489 Q6ZV73 E1393K Polymorphism 0.112 0.465 0.08 43 0.258 Q6ZV77 K168E Polymorphism NA 0.180 NA 21 0.050 Q6ZVD7 R18P Disease NA 0.529 NA 63 0.357 Q6ZVD7 A863T Polymorphism 0.337 0.240 NA -19 0.135 Q6ZVD7 N825I Disease 0.801 0.148 NA 41 0.211 Q6ZVD7 Y153H Disease 0.699 0.315 NA 26 0.485 Q6ZVF9 L39V Polymorphism 0.159 0.040 NA -4 0.026 Q6ZVH7 A574S Polymorphism 0.071 0.104 0.01 -20 0.088 Q6ZVH7 I568V Polymorphism 0.056 0.085 0.01 -39 0.024 Q6ZVH7 Q829R Polymorphism 0.082 0.058 NA -10 0.059 Q6ZVH7 R167Q Polymorphism 0.133 0.213 0.39 44 0.199 Q6ZVL8 G75R Polymorphism NA 0.413 NA 43 0.086 Q6ZVL8 C136S Polymorphism NA 0.395 NA 45 0.108 Q6ZVN6 S53I Polymorphism NA 0.163 NA 26 0.013 Q6ZVN8 C80R Disease NA 0.934 0.00 62 0.925 Q6ZVN8 G99R Disease NA 0.905 0.00 61 0.904 Q6ZVN8 S85P Disease NA 0.500 0.05 34 0.705 Q6ZVN8 A168D Disease NA 0.567 0.02 45 0.715 Q6ZVN8 A310G Polymorphism NA 0.140 0.11 -5 0.111 Q6ZVN8 C321W Disease NA 0.915 0.00 66 0.930 Q6ZVN8 D172E Disease NA 0.849 0.00 58 0.893 Q6ZVN8 F170S Disease NA 0.940 0.00 58 0.915 Q6ZVN8 G250V Disease NA 0.956 0.00 63 0.940 Q6ZVN8 G320V Disease NA 0.938 0.00 62 0.923 Q6ZVN8 I222N Disease NA 0.889 0.00 38 0.784 Q6ZVN8 L101P Disease NA 0.970 0.00 52 0.836 Q6ZVN8 R288W Disease NA 0.933 0.00 71 0.938 Q6ZVN8 S205R Disease NA 0.603 0.03 31 0.586 Q6ZVN8 W191C Disease NA 0.980 0.00 66 0.940 Q6ZVT0 G578D Polymorphism 0.273 0.279 0.02 45 0.373 Q6ZVT0 S448N Polymorphism 0.117 0.173 0.60 -29 0.115 Q6ZVT0 V249A Polymorphism NA 0.115 0.64 15 0.089 Q6ZVT6 D304E Polymorphism 0.236 0.164 0.61 -5 0.147 Q6ZVW7 L333P Polymorphism NA 0.083 NA 23 0.033 Q6ZW33 Y93S Polymorphism 0.302 0.199 NA 18 0.193 Q6ZW61 I39T Polymorphism NA 0.389 0.00 44 0.573 Q6ZW61 A289P Disease NA 0.591 0.00 56 0.697 Q6ZW61 A615V Polymorphism NA 0.273 0.00 40 0.402 Q6ZW61 D467N Polymorphism NA 0.060 1.00 -30 0.006 Q6ZW61 E126D Polymorphism NA 0.209 0.61 5 0.160 Q6ZW61 G540V Disease NA 0.703 0.00 67 0.877 Q6ZW61 I170V Polymorphism NA 0.038 0.89 -15 0.026 Q6ZW61 N461H Polymorphism NA 0.331 0.00 37 0.533 Q6ZW61 P159L Disease NA 0.176 0.19 27 0.157 Q6ZW61 R484K Polymorphism NA 0.075 1.00 14 0.067 Q6ZW76 A404T Polymorphism 0.089 0.051 0.45 -12 0.049 Q6ZW76 A593T Polymorphism 0.031 0.061 0.09 -6 0.032 Q6ZWB6 P329L Polymorphism 0.161 0.082 0.00 19 0.137 Q6ZWH5 L513S Polymorphism NA 0.435 0.10 13 0.249 Q6ZWH5 L701V Polymorphism 0.611 0.171 0.43 8 0.261 Q6ZWH5 N659S Polymorphism 0.562 0.160 0.04 -32 0.229 Q6ZWI9 G234D Polymorphism NA 0.453 0.61 4 0.262 Q6ZWJ8 D623V Polymorphism 0.038 0.416 0.17 43 0.448 Q6ZWJ8 K397E Polymorphism 0.038 0.120 1.00 44 0.165 Q6ZWK6 A4T Polymorphism NA 0.133 0.07 -10 0.097 Q6ZWK6 D124N Polymorphism NA 0.108 0.50 -11 0.099 Q6ZWL3 E79D Disease 0.262 0.400 0.58 -24 0.257 Q6ZWL3 G61S Disease 0.970 0.929 0.00 65 0.955 Q6ZWL3 L22V Polymorphism 0.084 0.331 0.87 -32 0.205 Q6ZWL3 W44R Disease 0.121 0.602 0.32 19 0.154 Q6ZWL3 E275K Polymorphism 0.201 0.523 0.33 -8 0.263 Q6ZWL3 H331P Disease 0.950 0.903 0.00 55 0.757 Q6ZWL3 I111T Disease 0.678 0.591 0.01 32 0.765 Q6ZWL3 M123V Disease 0.160 0.190 0.56 -12 0.131 Q6ZWL3 R443Q Polymorphism 0.556 0.808 0.13 55 0.904 Q6ZWL3 R508H Disease NA 0.732 0.02 45 0.643 Q6ZWL3 S213N Polymorphism 0.237 0.275 0.47 -34 0.191 Q6ZWL3 S341P Disease 0.479 0.746 0.26 27 0.758 Q6ZWT7 T501A Polymorphism 0.113 0.094 0.59 -15 0.090 Q6ZYL4 L21P Disease NA 0.699 0.03 39 0.764 Q702N8 D3N Polymorphism NA 0.041 NA -29 0.024 Q702N8 H965P Polymorphism 0.192 0.021 0.26 -8 0.019 Q702N8 G1604R Polymorphism 0.357 0.036 0.19 5 0.016 Q702N8 I1724V Polymorphism 0.171 0.067 0.21 -30 0.010 Q709C8 R153H Polymorphism NA 0.173 0.07 39 0.320 Q709C8 I1132V Polymorphism 0.432 0.354 0.06 -12 0.294 Q709C8 I1495V Polymorphism 0.091 0.277 1.00 -1 0.202 Q709C8 K2808R Polymorphism 0.183 0.353 0.16 14 0.242 Q709C8 S1592Y Polymorphism 0.400 0.264 0.01 12 0.365 Q709C8 S2913N Polymorphism 0.103 0.061 1.00 -16 0.018 Q709C8 T1485A Polymorphism 0.123 0.114 0.48 17 0.148 Q709C8 V2322M Polymorphism NA 0.166 0.09 -44 0.130 Q70CQ2 M661T Polymorphism NA 0.095 NA 30 0.009 Q70CQ2 D2348N Polymorphism NA 0.242 0.29 9 0.287 Q70CQ4 I538T Polymorphism NA 0.174 0.21 -27 0.100 Q70CQ4 D1269N Polymorphism NA 0.084 0.00 31 0.163 Q70EK8 S962R Polymorphism 0.124 0.156 NA 8 0.125 Q70EL1 K976E Polymorphism NA 0.160 NA -33 0.027 Q70HW3 T208M Polymorphism 0.655 0.594 0.27 -53 0.358 Q70J99 H858Q Polymorphism 0.455 0.586 0.02 40 0.760 Q70J99 K867E Polymorphism 0.198 0.115 1.00 1 0.088 Q70UQ0 G265S Polymorphism 0.184 0.031 0.49 -29 0.042 Q70Z35 D312N Polymorphism 0.277 0.482 0.04 49 0.471 Q70Z44 A171G Polymorphism 0.156 0.423 0.69 21 0.346 Q70Z44 R435H Polymorphism 0.633 0.297 0.34 21 0.471 Q70Z53 S251F Polymorphism 0.438 0.087 0.08 10 0.180 Q711Q0 D741G Polymorphism NA 0.113 NA 19 0.114 Q711Q0 F958Y Polymorphism NA 0.212 NA 2 0.156 Q711Q0 N208K Polymorphism NA 0.090 NA 16 0.086 Q711Q0 G1084A Polymorphism NA 0.048 NA -15 0.013 Q711Q0 V1254I Polymorphism NA 0.038 NA -26 0.009 Q71DI3 M91T Polymorphism 0.127 0.761 0.69 -29 0.256 Q71DI3 A128V Polymorphism 0.349 0.941 0.09 -28 0.618 Q71F23 G16S Polymorphism NA 0.086 0.22 17 0.048 Q71F56 E251G Disease NA 0.086 0.04 7 0.116 Q71F56 D2023G Disease 0.444 0.661 0.02 25 0.587 Q71F56 R1872H Disease 0.797 0.713 0.01 23 0.830 Q71H61 V202I Polymorphism NA 0.123 0.30 7 0.188 Q71RC2 F351L Polymorphism 0.238 0.599 0.00 19 0.473 Q71RG4 R228H Polymorphism 0.268 0.066 0.18 8 0.127 Q71RS6 T111A Polymorphism 0.558 0.138 1.00 -3 0.055 Q71U36 E447K Polymorphism 0.074 0.444 0.26 4 0.232 Q71U36 I188L Disease 0.149 0.339 0.52 -46 0.229 Q71U36 L286F Disease 0.259 0.779 0.10 -31 0.436 Q71U36 P263T Disease 0.752 0.883 0.00 37 0.864 Q71U36 R264C Disease 0.845 0.945 0.00 33 0.876 Q71U36 R402C Disease NA 0.948 0.00 0 0.745 Q71U36 R402H Disease NA 0.706 0.00 -31 0.535 Q71U36 S419L Disease 0.246 0.382 0.02 -35 0.367 Q75LS8 V125G Polymorphism NA 0.657 0.00 38 0.739 Q75MW2 Q38R Polymorphism NA 0.064 1.00 -2 0.023 Q75MW2 A131T Polymorphism NA 0.023 NA 22 0.033 Q75MW2 T134A Polymorphism NA 0.037 NA 30 0.036 Q75N90 D868N Polymorphism NA 0.397 0.10 9 0.243 Q75N90 G119A Polymorphism NA 0.127 0.71 9 0.181 Q75N90 M371I Polymorphism NA 0.143 0.39 -8 0.107 Q75N90 P329L Polymorphism NA 0.244 0.77 24 0.366 Q75N90 R473Q Polymorphism NA 0.228 0.40 6 0.174 Q75N90 R935L Polymorphism NA 0.546 0.19 47 0.252 Q75N90 E1850K Polymorphism 0.469 0.360 0.02 60 0.556 Q75N90 H1966D Polymorphism 0.091 0.218 0.32 51 0.279 Q75N90 H2540Q Polymorphism NA 0.285 0.26 49 0.382 Q75N90 L1904F Polymorphism 0.087 0.167 0.19 -11 0.097 Q75N90 L1904P Polymorphism 0.570 0.189 0.13 19 0.415 Q75N90 N1431I Polymorphism 0.289 0.302 0.06 38 0.353 Q75N90 P1958H Polymorphism 0.845 0.183 0.01 49 0.531 Q75N90 Q1209R Polymorphism NA 0.344 0.20 36 0.298 Q75N90 R1083W Polymorphism 0.625 0.185 0.02 58 0.558 Q75N90 R2471H Polymorphism NA 0.603 0.13 32 0.369 Q75N90 S1293G Polymorphism 0.179 0.221 0.36 13 0.140 Q75N90 S1293N Polymorphism 0.089 0.239 0.42 -6 0.134 Q75N90 S2314N Polymorphism NA 0.315 0.11 29 0.279 Q75N90 T1939N Polymorphism 0.127 0.156 0.45 15 0.101 Q75N90 V2594I Polymorphism NA 0.135 0.55 -13 0.142 Q75V66 C356G Disease 0.644 0.952 0.22 47 0.720 Q75V66 C356R Disease 0.944 0.975 0.02 68 0.943 Q75WM6 R84G Polymorphism NA 0.045 0.14 -12 0.008 Q75WM6 R174Q Polymorphism NA 0.208 NA 0 0.182 Q75WM6 R195Q Polymorphism NA 0.208 NA 32 0.195 Q75WM6 S237F Polymorphism NA 0.048 NA 15 0.059 Q765I0 S21I Polymorphism NA 0.121 NA -58 0.010 Q76EJ3 A184S Polymorphism 0.708 0.820 0.16 28 0.699 Q76FK4 D841E Polymorphism NA 0.033 0.27 -73 0.096 Q76FK4 V748L Polymorphism NA 0.053 0.20 5 0.069 Q76FK4 G1021S Polymorphism NA 0.045 NA -3 0.056 Q76I76 S743L Polymorphism NA 0.301 0.00 10 0.196 Q76L83 T1210P Polymorphism NA 0.065 0.05 -2 0.063 Q76L83 T1242P Polymorphism 0.461 0.241 0.02 14 0.204 Q76LX8 H96D Disease 0.429 0.902 0.00 57 0.895 Q76LX8 V88M Disease 0.456 0.531 0.05 31 0.622 Q76LX8 A250V Disease 0.353 0.628 0.01 28 0.713 Q76LX8 C508Y Disease 0.998 0.884 0.00 36 0.928 Q76LX8 C908Y Disease 0.997 0.890 0.01 67 0.943 Q76LX8 C951G Disease 0.315 0.823 0.04 51 0.754 Q76LX8 E740K Polymorphism 0.171 0.706 0.23 33 0.211 Q76LX8 G982R Polymorphism 0.088 0.902 0.08 19 0.193 Q76LX8 H234Q Disease 0.997 0.754 0.00 57 0.957 Q76LX8 I673F Disease 0.444 0.742 0.01 44 0.638 Q76LX8 R102C Disease 0.775 0.791 0.05 43 0.815 Q76LX8 R193W Disease 0.833 0.693 0.03 48 0.889 Q76LX8 R268P Disease 0.610 0.625 0.25 59 0.835 Q76LX8 R398H Disease 0.614 0.693 0.00 38 0.854 Q76LX8 R528G Disease 0.550 0.627 0.15 30 0.762 Q76LX8 R625H Polymorphism NA 0.684 0.23 47 0.734 Q76LX8 R692C Disease 0.796 0.721 0.05 12 0.774 Q76LX8 T196I Disease 0.403 0.400 0.02 40 0.601 Q76LX8 W390C Disease 0.998 0.885 0.00 59 0.961 Q76LX8 C1024G Disease 0.497 0.814 0.00 56 0.833 Q76LX8 C1213Y Disease NA 0.561 NA 61 0.809 Q76LX8 G1239V Disease NA 0.159 NA 43 0.199 Q76LX8 R1123C Disease 0.721 0.732 0.02 53 0.885 Q76LX8 R1336W Disease NA 0.278 NA 49 0.423 Q76LX8 T1226I Polymorphism NA 0.120 NA 34 0.124 Q76MJ5 V69I Polymorphism NA 0.111 0.00 -24 0.123 Q76MJ5 R118C Polymorphism NA 0.724 0.00 44 0.789 Q76MJ5 R537Q Polymorphism NA 0.585 0.16 16 0.492 Q76N32 G74S Polymorphism NA 0.030 0.66 19 0.032 Q76N32 E473Q Polymorphism 0.246 0.120 0.31 -4 0.089 Q76N32 L397P Polymorphism 0.402 0.212 0.05 41 0.085 Q76N32 R462C Polymorphism 0.135 0.098 0.10 -15 0.047 Q76NI1 E436G Polymorphism NA 0.049 NA -2 0.067 Q76NI1 A1332T Polymorphism NA 0.025 0.00 -27 0.045 Q7KYR7 R124C Polymorphism 0.292 0.642 0.04 12 0.452 Q7KYR7 V207M Polymorphism 0.443 0.332 0.11 -23 0.405 Q7KZN9 R217W Disease 0.952 0.870 0.02 59 0.929 Q7KZN9 S344P Disease 0.739 0.776 0.11 16 0.798 Q7L0Q8 T121A Polymorphism 0.141 0.047 1.00 14 0.142 Q7L0X0 A347T Polymorphism 0.312 0.428 0.54 -16 0.183 Q7L0X0 G369D Polymorphism 0.545 0.342 0.91 18 0.483 Q7L0X2 G9V Polymorphism NA 0.323 NA 33 0.105 Q7L0X2 G433R Polymorphism 0.662 0.426 0.12 24 0.494 Q7L0Y3 P56R Polymorphism NA 0.053 0.10 -2 0.060 Q7L1W4 S371Y Polymorphism NA 0.347 0.05 -28 0.472 Q7L2H7 Q346R Polymorphism 0.222 0.829 0.01 39 0.631 Q7L2K0 R346K Polymorphism NA 0.066 NA 9 0.060 Q7L3B6 S291F Polymorphism NA 0.354 0.03 -15 0.496 Q7L3T8 R28S Polymorphism NA 0.219 0.02 33 0.148 Q7L3T8 N235S Polymorphism 0.180 0.524 0.75 -42 0.137 Q7L3V2 D123Y Polymorphism NA 0.664 0.12 40 0.286 Q7L513 R349Q Polymorphism 0.070 0.093 0.32 -14 0.050 Q7L576 A532P Polymorphism 0.472 0.461 0.08 -27 0.427 Q7L576 G820D Polymorphism 0.131 0.175 0.30 -40 0.033 Q7L590 A418V Polymorphism 0.500 0.158 0.98 39 0.249 Q7L590 K134R Polymorphism 0.156 0.035 0.63 -42 0.057 Q7L590 K669R Polymorphism 0.362 0.264 0.00 18 0.278 Q7L591 R12P Polymorphism NA 0.485 NA 58 0.301 Q7L592 P39A Polymorphism 0.124 0.212 0.80 9 0.193 Q7L5A8 D35Y Disease 0.967 0.971 0.00 67 0.971 Q7L5N7 M163I Polymorphism 0.695 0.047 0.97 -15 0.015 Q7L5Y1 D31E Polymorphism NA 0.666 0.00 26 0.577 Q7L5Y1 M145T Polymorphism 0.130 0.344 0.62 33 0.161 Q7L5Y9 R34C Polymorphism NA 0.824 0.00 20 0.811 Q7L622 R232H Polymorphism 0.325 0.394 0.64 -6 0.254 Q7L775 A360S Polymorphism 0.257 0.066 0.41 -13 0.084 Q7L775 V333F Polymorphism 0.461 0.664 0.06 36 0.553 Q7L7V1 D301A Polymorphism 0.575 0.550 0.58 15 0.476 Q7L7V1 E271D Polymorphism 0.680 0.520 0.38 -44 0.562 Q7L804 F152V Polymorphism 0.055 0.822 0.51 43 0.333 Q7L8L6 I288T Polymorphism 0.320 0.507 0.23 39 0.527 Q7L8L6 I377V Polymorphism 0.192 0.134 0.11 18 0.191 Q7L8W6 G41E Polymorphism 0.404 0.215 1.00 2 0.235 Q7L985 R507H Polymorphism NA 0.237 0.16 23 0.381 Q7L9B9 A358S Polymorphism 0.113 0.087 0.15 8 0.019 Q7L9B9 P416S Polymorphism 0.154 0.036 0.91 13 0.040 Q7LBE3 V744M Polymorphism 0.327 0.150 0.19 -21 0.235 Q7LDG7 G493A Polymorphism 0.156 0.112 1.00 -14 0.177 Q7LG56 W64R Disease 0.932 0.942 0.00 69 0.949 Q7LG56 C236F Disease 0.341 0.758 0.00 5 0.538 Q7LG56 E194G Disease 0.785 0.836 0.00 64 0.919 Q7LG56 E194K Disease 0.612 0.895 0.00 76 0.886 Q7LG56 I224S Disease 0.785 0.905 0.00 2 0.741 Q7LG56 L317V Disease 0.272 0.679 0.10 7 0.426 Q7LG56 M282I Disease 0.244 0.549 0.13 -15 0.394 Q7LGC8 E372K Disease 0.956 0.972 0.00 72 0.967 Q7LGC8 I348M Polymorphism 0.431 0.135 0.24 -15 0.127 Q7LGC8 L259P Disease 0.859 0.874 0.02 52 0.922 Q7LGC8 L307P Disease 0.883 0.905 0.06 63 0.935 Q7LGC8 R222W Disease 0.942 0.300 0.06 17 0.551 Q7LGC8 R304Q Disease 0.957 0.922 0.02 71 0.963 Q7RTM1 D309E Polymorphism 0.157 0.119 1.00 36 0.091 Q7RTM1 Q516H Polymorphism 0.230 0.097 0.18 39 0.110 Q7RTN6 P64S Polymorphism 0.458 0.478 0.35 -12 0.431 Q7RTP0 T45R Disease 0.546 0.564 0.01 11 0.673 Q7RTP0 G106R Disease 0.323 0.749 0.03 12 0.595 Q7RTP6 R745Q Polymorphism NA 0.184 0.51 0 0.197 Q7RTR8 Y265C Polymorphism NA 0.273 0.15 5 0.386 Q7RTS3 S263P Polymorphism 0.568 0.267 0.03 28 0.391 Q7RTS5 R64Q Polymorphism NA 0.040 0.44 30 0.027 Q7RTS5 S199P Polymorphism 0.074 0.152 1.00 -5 0.036 Q7RTS6 G465W Polymorphism 0.472 0.472 0.02 33 0.639 Q7RTS7 E271D Polymorphism 0.558 0.857 0.17 22 0.557 Q7RTS9 E87K Disease 0.636 0.552 0.03 37 0.613 Q7RTS9 N469Y Disease 0.855 0.895 0.00 63 0.936 Q7RTT3 C72R Polymorphism 0.126 0.349 0.50 33 0.179 Q7RTT9 P429T Polymorphism 0.308 0.906 0.00 38 0.734 Q7RTU1 R25Q Polymorphism 0.388 0.084 0.02 34 0.127 Q7RTU9 L1640F Polymorphism NA 0.106 0.08 23 0.113 Q7RTV5 R83K Polymorphism NA 0.034 1.00 -59 0.021 Q7RTX1 K347E Polymorphism 0.118 0.264 1.00 11 0.186 Q7RTX1 R507Q Polymorphism 0.393 0.372 0.02 18 0.454 Q7RTX7 D436N Polymorphism NA 0.053 NA 30 0.062 Q7RTX7 I293V Polymorphism 0.071 0.143 0.14 -4 0.094 Q7RTX7 L124F Polymorphism 0.196 0.414 0.16 45 0.299 Q7RTY1 D461E Polymorphism 0.517 0.733 0.20 52 0.667 Q7RTY7 I444T Polymorphism NA 0.153 0.60 24 0.072 Q7RTY7 K330E Polymorphism NA 0.106 0.10 45 0.101 Q7RTZ1 R19Q Polymorphism NA 0.143 0.38 -56 0.090 Q7RTZ1 T24A Polymorphism NA 0.097 0.14 7 0.122 Q7RTZ1 G381E Polymorphism NA 0.250 0.36 66 0.442 Q7RTZ1 N410T Polymorphism NA 0.074 0.44 12 0.033 Q7RTZ1 N410Y Polymorphism NA 0.221 1.00 22 0.056 Q7Z2D5 Q2K Polymorphism NA 0.144 0.00 -9 0.122 Q7Z2D5 A32V Polymorphism NA 0.119 0.00 4 0.162 Q7Z2E3 A212V Disease NA 0.842 0.03 40 0.823 Q7Z2E3 D281G Disease NA 0.964 0.01 40 0.836 Q7Z2E3 H215R Disease NA 0.954 0.00 65 0.941 Q7Z2E3 K211Q Disease NA 0.936 0.19 12 0.726 Q7Z2E3 L237P Disease NA 0.982 0.00 53 0.849 Q7Z2E3 P220L Disease NA 0.883 0.00 43 0.844 Q7Z2E3 R213H Disease NA 0.594 0.07 26 0.536 Q7Z2E3 V277G Disease NA 0.877 0.00 42 0.841 Q7Z2E3 W293R Disease NA 0.945 0.00 51 0.889 Q7Z2G1 R123H Polymorphism 0.287 0.641 0.25 0 0.412 Q7Z2H8 F362L Polymorphism 0.787 0.396 0.45 -53 0.528 Q7Z2K6 S44N Polymorphism NA 0.043 0.31 -29 0.023 Q7Z2W4 H565Q Polymorphism NA 0.070 0.22 17 0.110 Q7Z2W4 Q701E Polymorphism NA 0.045 0.73 36 0.113 Q7Z2W4 T851I Polymorphism NA 0.742 0.37 3 0.492 Q7Z2Y5 E579G Polymorphism NA 0.159 0.12 25 0.113 Q7Z2Y5 E679G Polymorphism 0.447 0.262 0.00 18 0.201 Q7Z2Y5 P426A Polymorphism 0.134 0.073 0.04 35 0.075 Q7Z2Y5 A1121P Polymorphism NA 0.132 0.01 20 0.105 Q7Z2Y5 M1472L Polymorphism NA 0.352 0.21 -24 0.228 Q7Z2Y5 P1106S Polymorphism NA 0.069 0.26 17 0.024 Q7Z2Z1 R287C Polymorphism NA 0.040 NA -11 0.016 Q7Z2Z1 R628C Polymorphism NA 0.293 NA 45 0.294 Q7Z2Z1 V747A Polymorphism NA 0.150 NA 19 0.124 Q7Z2Z1 S1718T Polymorphism 0.214 0.066 0.09 -13 0.041 Q7Z2Z2 E478D Polymorphism 0.072 0.096 0.39 -16 0.091 Q7Z2Z2 I617V Polymorphism 0.268 0.133 1.00 34 0.150 Q7Z2Z2 K711R Polymorphism NA 0.701 NA 17 0.508 Q7Z333 T3I Disease 0.219 0.203 NA 11 0.175 Q7Z333 A660G Polymorphism NA 0.160 NA 26 0.142 Q7Z333 L389S Disease NA 0.480 NA 40 0.599 Q7Z333 M274I Disease 0.106 0.347 NA 39 0.450 Q7Z333 N603D Disease NA 0.113 NA 14 0.110 Q7Z333 P413L Disease NA 0.480 NA 40 0.632 Q7Z333 Q653K Disease NA 0.144 NA 17 0.134 Q7Z333 R332W Disease 0.690 0.491 NA 45 0.696 Q7Z333 W305C Disease 0.615 0.426 NA 61 0.587 Q7Z333 F1152C Polymorphism NA 0.186 NA 38 0.193 Q7Z333 F1756S Disease NA 0.652 0.00 36 0.710 Q7Z333 P1061L Polymorphism NA 0.087 NA -25 0.018 Q7Z333 P2213L Disease 0.549 0.889 0.00 37 0.872 Q7Z333 P2368R Disease 0.515 0.461 0.03 16 0.513 Q7Z333 R1294C Disease NA 0.390 NA 37 0.429 Q7Z333 R2136H Disease 0.543 0.646 0.08 -10 0.531 Q7Z333 S2612G Polymorphism 0.133 0.071 0.01 12 0.080 Q7Z333 T1855A Polymorphism NA 0.083 0.02 20 0.126 Q7Z353 F397S Polymorphism NA 0.326 NA 39 0.290 Q7Z398 I359T Polymorphism 0.358 0.259 0.78 -39 0.268 Q7Z3B3 K104T Polymorphism 0.330 0.339 NA 17 0.409 Q7Z3B3 N225D Polymorphism 0.219 0.144 NA 27 0.083 Q7Z3B3 I1085T Polymorphism 0.329 0.093 NA 5 0.084 Q7Z3B3 P1010L Polymorphism 0.139 0.095 0.00 -8 0.093 Q7Z3D6 R10C Polymorphism NA 0.058 0.03 -12 0.054 Q7Z3D6 G583D Polymorphism NA 0.641 NA 56 0.703 Q7Z3D6 S237N Polymorphism NA 0.159 0.10 -27 0.166 Q7Z3E2 Q271K Polymorphism 0.122 0.020 0.84 -33 0.023 Q7Z3E5 I209T Polymorphism NA 0.075 0.17 -14 0.027 Q7Z3E5 L108F Polymorphism NA 0.284 0.15 7 0.378 Q7Z3E5 R222H Polymorphism NA 0.136 0.51 -40 0.087 Q7Z3I7 G380E Polymorphism 0.767 0.236 0.03 53 0.539 Q7Z3I7 S448C Polymorphism 0.613 0.365 0.03 2 0.538 Q7Z3I7 V500I Polymorphism 0.088 0.353 0.00 21 0.435 Q7Z3J2 Y32C Polymorphism 0.243 0.757 0.00 -5 0.630 Q7Z3J2 A506V Polymorphism 0.120 0.314 0.67 2 0.172 Q7Z3J2 N186I Polymorphism 0.220 0.201 0.03 -10 0.226 Q7Z3K6 N414K Polymorphism 0.448 0.316 0.49 10 0.255 Q7Z3K6 N530S Polymorphism 0.335 0.059 0.10 -14 0.023 Q7Z3S7 R863H Polymorphism 0.482 0.126 0.04 27 0.247 Q7Z3S9 S67P Polymorphism NA 0.179 0.40 -42 0.278 Q7Z3S9 E226Q Polymorphism NA 0.044 0.44 38 0.104 Q7Z3S9 T158I Polymorphism 0.078 0.269 0.03 14 0.227 Q7Z3S9 T196S Polymorphism 0.257 0.177 0.08 6 0.221 Q7Z3T1 C169S Polymorphism 0.953 0.881 0.00 68 0.927 Q7Z3T1 E196D Polymorphism 0.554 0.768 0.18 -3 0.507 Q7Z3T1 R179C Polymorphism 0.831 0.241 1.00 3 0.007 Q7Z3T1 V190I Polymorphism 0.620 0.290 0.19 26 0.572 Q7Z3T8 A35E Polymorphism NA 0.299 0.00 28 0.189 Q7Z3V5 K170M Polymorphism 0.843 0.527 0.06 36 0.863 Q7Z3V5 L573H Polymorphism 0.876 0.791 0.00 71 0.996 Q7Z3V5 Q189H Polymorphism 0.816 0.300 1.00 -35 0.010 Q7Z3Y7 A286T Polymorphism 0.370 0.476 0.10 -41 0.376 Q7Z3Y8 A284T Polymorphism 0.370 0.450 0.12 -39 0.334 Q7Z3Y9 W118R Polymorphism 0.508 0.702 0.14 55 0.663 Q7Z3Z2 W6R Polymorphism NA 0.759 NA 72 0.891 Q7Z3Z2 E23D Polymorphism NA 0.173 NA 25 0.151 Q7Z3Z2 R47C Polymorphism NA 0.291 NA 37 0.410 Q7Z3Z2 R68W Polymorphism NA 0.247 NA 53 0.438 Q7Z3Z2 R167K Polymorphism NA 0.034 NA -31 0.056 Q7Z3Z3 C412R Polymorphism 0.198 0.194 0.85 5 0.150 Q7Z3Z3 P375S Polymorphism 0.453 0.644 0.07 49 0.747 Q7Z3Z3 R589C Polymorphism 0.565 0.650 0.05 37 0.785 Q7Z3Z3 V418M Polymorphism 0.700 0.141 1.00 -45 0.117 Q7Z3Z4 Q78R Polymorphism NA 0.177 0.81 -6 0.098 Q7Z3Z4 K167R Polymorphism 0.099 0.077 0.43 -24 0.106 Q7Z3Z4 Q327L Polymorphism 0.224 0.260 0.28 11 0.278 Q7Z401 L284P Polymorphism 0.088 0.939 0.04 40 0.267 Q7Z402 R59W Polymorphism 0.186 0.146 0.05 10 0.219 Q7Z406 G376C Disease 0.988 0.939 0.00 51 0.940 Q7Z406 L976F Disease 0.652 0.444 0.01 11 0.639 Q7Z406 P334A Polymorphism NA 0.114 0.53 -39 0.218 Q7Z406 R726S Disease 0.971 0.863 0.00 53 0.930 Q7Z406 S120L Disease 0.721 0.752 0.01 19 0.833 Q7Z406 A1209E Polymorphism 0.123 0.771 0.21 -19 0.295 Q7Z406 V1540I Polymorphism NA 0.106 0.08 -9 0.223 Q7Z407 I219M Polymorphism NA 0.330 0.27 41 0.361 Q7Z407 N3621H Polymorphism NA 0.142 0.04 15 0.235 Q7Z407 V3000L Polymorphism 0.221 0.349 0.47 30 0.295 Q7Z408 L167P Polymorphism NA 0.403 0.34 0 0.174 Q7Z408 L2661R Polymorphism 0.862 0.591 0.00 63 0.948 Q7Z408 L2661V Polymorphism 0.559 0.441 0.00 50 0.645 Q7Z408 M2554V Polymorphism NA 0.177 0.22 4 0.150 Q7Z408 R2096K Polymorphism NA 0.091 0.95 22 0.144 Q7Z408 S3406F Polymorphism NA 0.384 NA 42 0.595 Q7Z410 T4A Polymorphism NA 0.064 0.00 14 0.120 Q7Z410 R73W Polymorphism NA 0.252 0.03 31 0.415 Q7Z410 E938K Polymorphism NA 0.196 0.83 42 0.391 Q7Z410 S793N Polymorphism NA 0.165 0.53 29 0.157 Q7Z412 G89R Disease NA 0.500 NA 61 0.794 Q7Z412 L45P Disease NA 0.822 NA 55 0.875 Q7Z412 R98W Disease NA 0.595 NA 40 0.711 Q7Z412 L153V Polymorphism NA 0.094 NA 25 0.097 Q7Z418 F58Y Polymorphism 0.436 0.260 1.00 -8 0.244 Q7Z418 A198G Polymorphism 0.770 0.034 0.41 42 0.074 Q7Z418 A233V Polymorphism NA 0.038 0.20 12 0.076 Q7Z418 E255K Polymorphism NA 0.214 0.12 59 0.245 Q7Z418 V346I Polymorphism 0.466 0.052 0.54 -16 0.072 Q7Z429 S107N Polymorphism NA 0.212 0.15 25 0.217 Q7Z434 C79F Polymorphism 0.767 0.732 0.00 50 0.729 Q7Z434 Q198K Polymorphism 0.062 0.138 1.00 43 0.173 Q7Z434 S409F Polymorphism 0.049 0.130 0.06 43 0.111 Q7Z442 V20A Polymorphism NA 0.081 0.13 -17 0.021 Q7Z442 W73R Polymorphism NA 0.142 0.57 71 0.065 Q7Z442 A863V Polymorphism NA 0.078 0.12 30 0.093 Q7Z442 C162S Polymorphism NA 0.527 NA 50 0.723 Q7Z442 L173S Polymorphism NA 0.156 0.27 -12 0.035 Q7Z442 L462V Polymorphism NA 0.133 NA -32 0.083 Q7Z442 N407S Polymorphism NA 0.196 NA 43 0.337 Q7Z442 P301A Polymorphism NA 0.159 NA 47 0.211 Q7Z442 P512L Polymorphism NA 0.169 NA 35 0.144 Q7Z442 Q120L Polymorphism NA 0.239 0.01 45 0.416 Q7Z442 V156I Polymorphism NA 0.140 0.21 37 0.135 Q7Z442 V169M Polymorphism NA 0.111 0.00 -13 0.072 Q7Z442 L2119I Polymorphism 0.154 0.289 0.02 5 0.300 Q7Z442 M1042V Polymorphism NA 0.150 0.71 20 0.111 Q7Z442 M1645V Polymorphism NA 0.080 0.15 22 0.052 Q7Z442 M1867V Polymorphism 0.097 0.093 0.76 -27 0.096 Q7Z442 Q1701H Polymorphism NA 0.134 0.40 43 0.144 Q7Z442 Q2036R Polymorphism 0.107 0.103 0.85 -36 0.092 Q7Z442 S1326P Polymorphism NA 0.323 1.00 -32 0.118 Q7Z442 S1665Y Polymorphism NA 0.195 0.84 36 0.261 Q7Z442 S2139F Polymorphism 0.356 0.145 0.47 -20 0.115 Q7Z442 T1048A Polymorphism NA 0.136 0.54 -33 0.101 Q7Z443 A471D Polymorphism NA 0.332 0.68 41 0.225 Q7Z443 H571Q Polymorphism NA 0.187 0.59 34 0.173 Q7Z443 V903I Polymorphism NA 0.367 0.53 20 0.366 Q7Z443 Y1474C Polymorphism 0.817 0.379 0.09 -28 0.503 Q7Z460 I233T Polymorphism NA 0.212 0.11 24 0.340 Q7Z465 S65N Polymorphism NA 0.109 0.51 24 0.191 Q7Z494 N386S Disease 0.310 0.170 0.00 27 0.213 Q7Z494 R397H Disease 0.336 0.170 0.01 54 0.263 Q7Z494 R973Q Disease 0.377 0.210 0.04 18 0.349 Q7Z494 S360T Disease 0.294 0.212 0.00 30 0.232 Q7Z494 A1221V Disease NA 0.604 0.03 8 0.279 Q7Z494 L1141P Disease NA 0.500 0.00 64 0.984 Q7Z494 R1305C Polymorphism NA 0.233 0.02 38 0.442 Q7Z494 S1252R Disease NA 0.610 0.01 19 0.410 Q7Z494 S1314T Disease NA 0.282 0.00 -42 0.309 Q7Z4F1 M139V Polymorphism NA 0.122 0.25 9 0.049 Q7Z4G1 H52N Polymorphism NA 0.201 0.25 -12 0.350 Q7Z4H7 H674Q Polymorphism 0.121 0.030 NA -3 0.051 Q7Z4H7 S761I Polymorphism 0.354 0.264 NA 39 0.241 Q7Z4H8 R319L Polymorphism NA 0.589 0.06 47 0.770 Q7Z4H9 G71R Polymorphism NA 0.060 0.67 16 0.051 Q7Z4H9 G237S Polymorphism NA 0.124 0.00 33 0.163 Q7Z4J2 A282E Polymorphism 0.061 0.127 1.00 2 0.146 Q7Z4L5 K846R Polymorphism 0.143 0.098 0.38 -1 0.128 Q7Z4L5 L473F Polymorphism 0.514 0.238 0.05 4 0.455 Q7Z4L5 P463S Polymorphism 0.514 0.299 0.23 -30 0.401 Q7Z4N2 V605M Polymorphism 0.329 0.161 0.10 17 0.238 Q7Z4N2 H1498Q Polymorphism 0.172 0.166 0.15 -14 0.018 Q7Z4N2 N1229T Polymorphism 0.255 0.077 0.54 -54 0.109 Q7Z4N2 R1305H Polymorphism 0.478 0.118 0.54 23 0.106 Q7Z4N8 D400N Polymorphism 0.320 0.436 0.53 17 0.335 Q7Z4Q2 R302S Polymorphism 0.177 0.147 NA 47 0.161 Q7Z4S6 M356T Disease 0.562 0.245 0.13 43 0.574 Q7Z4S6 M947R Disease NA 0.625 0.25 55 0.706 Q7Z4S6 M947T Disease NA 0.594 0.21 42 0.720 Q7Z4S6 M947V Disease NA 0.522 0.24 33 0.496 Q7Z4S6 R954Q Disease NA 0.477 0.57 46 0.646 Q7Z4S6 R954W Disease NA 0.723 0.03 46 0.803 Q7Z4S6 I1010T Disease NA 0.500 0.03 24 0.704 Q7Z4T9 S253T Polymorphism 0.214 0.034 NA -55 0.074 Q7Z4U5 D25Y Polymorphism NA 0.199 0.00 39 0.383 Q7Z4W2 D144G Polymorphism 0.105 0.236 1.00 6 0.135 Q7Z570 E542K Polymorphism 0.117 0.201 NA 35 0.197 Q7Z570 H747R Polymorphism 0.229 0.023 NA -14 0.049 Q7Z570 T707K Polymorphism 0.238 0.126 NA 52 0.098 Q7Z570 G1152R Polymorphism 0.575 0.353 0.22 38 0.435 Q7Z570 L1081V Polymorphism 0.155 0.029 0.50 -27 0.038 Q7Z572 I53L Polymorphism NA 0.078 0.63 5 0.033 Q7Z572 N390K Polymorphism NA 0.483 0.00 30 0.476 Q7Z572 V255L Polymorphism NA 0.056 1.00 -24 0.022 Q7Z591 R1119Q Polymorphism 0.142 0.148 0.27 40 0.145 Q7Z591 Y1327C Polymorphism 0.538 0.396 NA 37 0.570 Q7Z5H3 R612C Polymorphism 0.672 0.352 0.08 27 0.580 Q7Z5H5 D220N Polymorphism 0.866 0.648 0.97 -21 0.341 Q7Z5K2 V124I Polymorphism 0.173 0.041 NA 9 0.041 Q7Z5L2 D535A Polymorphism 0.190 0.085 NA 10 0.072 Q7Z5L2 H656R Polymorphism 0.355 0.165 0.20 -28 0.097 Q7Z5L2 S261G Polymorphism 0.316 0.105 NA 26 0.125 Q7Z5L9 A254V Polymorphism NA 0.056 0.55 19 0.030 Q7Z5M8 F334L Polymorphism 0.194 0.351 0.05 12 0.250 Q7Z5N4 D1016N Polymorphism NA 0.682 0.48 34 0.318 Q7Z5N4 H1641R Polymorphism NA 0.630 0.85 31 0.211 Q7Z5P9 C827Y Polymorphism 0.998 0.279 0.00 0 0.843 Q7Z5P9 D219H Polymorphism 0.215 0.447 0.14 0 0.208 Q7Z5P9 G712S Polymorphism 0.708 0.196 0.03 0 0.402 Q7Z5P9 I694M Polymorphism 0.628 0.182 0.11 0 0.425 Q7Z5P9 R207L Polymorphism 0.185 0.605 0.65 0 0.279 Q7Z5P9 S642F Polymorphism 0.833 0.668 0.29 0 0.780 Q7Z5P9 T199K Polymorphism 0.221 0.423 0.64 0 0.163 Q7Z5P9 V259I Polymorphism 0.222 0.244 0.14 0 0.300 Q7Z5P9 V285I Polymorphism 0.321 0.188 0.18 0 0.268 Q7Z5P9 V299I Polymorphism 0.187 0.176 0.04 0 0.231 Q7Z5P9 V909A Polymorphism 0.817 0.161 1.00 0 0.095 Q7Z5P9 A1462S Polymorphism NA 0.102 0.14 0 0.023 Q7Z5P9 N1037S Polymorphism 0.162 0.627 0.46 0 0.260 Q7Z5P9 S1186R Polymorphism NA 0.162 0.01 0 0.181 Q7Z5Q5 G336S Polymorphism NA 0.453 0.51 12 0.288 Q7Z5Q5 M310L Polymorphism 0.567 0.092 0.31 -12 0.032 Q7Z5Q5 Q121H Polymorphism NA 0.301 NA 36 0.208 Q7Z5Q5 R201G Polymorphism 0.581 0.191 NA 20 0.101 Q7Z5Q5 R425C Polymorphism 0.332 0.332 0.03 -6 0.307 Q7Z5R6 A617T Polymorphism 0.162 0.372 0.19 18 0.119 Q7Z5R6 T404A Polymorphism 0.188 0.189 0.45 -33 0.043 Q7Z5U6 H338P Polymorphism NA 0.164 0.16 34 0.163 Q7Z5V6 S382T Polymorphism NA 0.022 1.00 -37 0.033 Q7Z5V6 T238N Polymorphism NA 0.230 0.00 47 0.261 Q7Z5Y6 R293H Polymorphism 0.120 0.689 0.55 3 0.113 Q7Z5Y7 S171T Polymorphism 0.140 0.609 NA 11 0.384 Q7Z614 P35L Polymorphism 0.224 0.170 0.01 6 0.078 Q7Z628 T417I Polymorphism 0.717 0.401 0.19 16 0.575 Q7Z695 P626L Polymorphism NA 0.146 0.00 -2 0.329 Q7Z695 V418L Polymorphism 0.528 0.339 0.29 -40 0.541 Q7Z695 V418M Polymorphism 0.517 0.215 0.10 -38 0.459 Q7Z6A9 I124V Polymorphism NA 0.087 NA -15 0.049 Q7Z6E9 D43H Polymorphism NA 0.749 0.00 57 0.864 Q7Z6E9 K1208I Polymorphism 0.514 0.206 0.06 42 0.432 Q7Z6J0 P663S Polymorphism 0.195 0.077 0.75 -7 0.019 Q7Z6J4 Q32H Polymorphism NA 0.072 0.10 38 0.068 Q7Z6J8 T174P Polymorphism NA 0.328 0.03 42 0.542 Q7Z6J9 S93P Disease 0.715 0.429 0.06 26 0.610 Q7Z6J9 A307S Disease 0.258 0.286 0.00 9 0.340 Q7Z6M1 P58A Polymorphism 0.452 0.354 0.45 5 0.259 Q7Z6M1 R60G Polymorphism 0.060 0.621 0.88 18 0.048 Q7Z6M1 T67P Polymorphism 0.374 0.632 0.21 -4 0.452 Q7Z6M1 D313G Polymorphism 0.077 0.252 0.06 10 0.190 Q7Z6M4 T45A Polymorphism 0.191 0.288 0.00 34 0.397 Q7Z6M4 D378E Polymorphism 0.157 0.141 NA 0 0.072 Q7Z6M4 L339V Polymorphism 0.166 0.129 NA 16 0.104 Q7Z6M4 M189T Polymorphism 0.150 0.390 0.29 56 0.438 Q7Z6W7 E41A Polymorphism 0.344 0.357 0.39 18 0.368 Q7Z713 T152S Polymorphism NA 0.063 0.95 2 0.041 Q7Z745 M11V Polymorphism NA 0.085 NA -8 0.064 Q7Z745 N918K Polymorphism NA 0.085 0.31 20 0.130 Q7Z745 R526H Polymorphism NA 0.313 0.00 43 0.316 Q7Z794 A10T Polymorphism NA 0.124 0.73 -23 0.068 Q7Z7A1 A889T Polymorphism 0.174 0.150 0.56 32 0.108 Q7Z7A4 I426V Polymorphism NA 0.063 0.23 13 0.079 Q7Z7F7 R42H Polymorphism NA 0.291 0.00 64 0.383 Q7Z7G8 V866I Polymorphism NA 0.085 NA 29 0.089 Q7Z7G8 G2645D Disease NA 0.443 NA 72 0.678 Q7Z7G8 I2820T Disease NA 0.087 NA 35 0.095 Q7Z7G8 L2193R Disease NA 0.388 NA 52 0.627 Q7Z7G8 N2993S Disease NA 0.366 NA 50 0.646 Q7Z7G8 S2773L Disease NA 0.301 NA 31 0.369 Q7Z7G8 S3142R Polymorphism NA 0.253 NA 44 0.405 Q7Z7G8 V2584A Polymorphism NA 0.027 NA 2 0.063 Q7Z7G8 Y2341C Disease NA 0.324 NA 64 0.607 Q7Z7H8 V125I Polymorphism NA 0.064 0.05 6 0.097 Q7Z7J5 R131Q Polymorphism NA 0.045 0.37 22 0.051 Q7Z7K2 T324A Polymorphism NA 0.205 0.08 -56 0.264 Q7Z7L1 V121F Polymorphism 0.055 0.135 0.08 -20 0.030 Q7Z7L1 Y822C Polymorphism 0.793 0.822 0.14 20 0.659 Q7Z7L7 T539I Polymorphism 0.368 0.065 0.50 -23 0.037 Q7Z7L8 F151S Polymorphism NA 0.491 NA 17 0.355 Q7Z7L8 R110S Polymorphism NA 0.184 NA 18 0.057 Q7Z7M8 S137G Polymorphism NA 0.116 0.07 16 0.167 Q7Z7M9 P77L Polymorphism NA 0.220 0.00 32 0.204 Q86SG5 A84T Polymorphism 0.106 0.016 0.50 -41 0.009 Q86SH4 T50S Polymorphism NA 0.040 NA 3 0.026 Q86SJ6 A154T Polymorphism 0.198 0.509 0.18 21 0.284 Q86SJ6 I535T Polymorphism 0.136 0.213 0.24 -15 0.172 Q86SJ6 I644L Polymorphism 0.053 0.263 1.00 -61 0.117 Q86SM8 G159S Polymorphism 0.100 0.075 0.48 -6 0.132 Q86SQ0 P941S Polymorphism NA 0.130 0.65 -12 0.236 Q86SQ4 K230Q Polymorphism NA 0.108 NA -18 0.080 Q86SQ4 S123G Polymorphism NA 0.509 0.00 43 0.702 Q86SQ9 V253M Polymorphism 0.342 0.244 0.02 -13 0.152 Q86SX6 A146T Polymorphism NA 0.361 0.27 2 0.302 Q86T20 M141I Polymorphism NA 0.142 NA 25 0.059 Q86T26 D325A Polymorphism 0.555 0.059 1.00 -30 0.019 Q86T26 T348S Polymorphism 0.076 0.099 0.26 -16 0.102 Q86T65 R105H Polymorphism 0.239 0.731 0.09 25 0.624 Q86T90 R383C Polymorphism NA 0.274 0.00 33 0.266 Q86TB3 K2T Polymorphism NA 0.018 0.90 -45 0.016 Q86TB3 G810S Polymorphism NA 0.185 0.00 19 0.239 Q86TB3 H719Q Polymorphism NA 0.043 0.97 4 0.039 Q86TB3 K829N Polymorphism NA 0.251 0.00 29 0.184 Q86TB3 N916K Polymorphism NA 0.311 0.00 25 0.254 Q86TB3 R136S Polymorphism NA 0.063 1.00 43 0.034 Q86TB3 R825T Polymorphism NA 0.060 0.07 17 0.023 Q86TB3 S884L Polymorphism NA 0.157 0.00 18 0.222 Q86TB3 A1551S Polymorphism NA 0.103 0.24 0 0.067 Q86TB3 H1174P Polymorphism NA 0.237 0.00 39 0.228 Q86TB3 L1296V Polymorphism NA 0.031 0.08 -55 0.052 Q86TB3 P1449S Polymorphism NA 0.110 0.00 20 0.224 Q86TB3 R1884C Polymorphism NA 0.246 0.00 38 0.416 Q86TC9 S707N Polymorphism NA 0.117 0.53 30 0.105 Q86TE4 E308Q Polymorphism 0.271 0.065 0.00 -1 0.168 Q86TH1 E114K Disease 0.237 0.696 0.24 53 0.689 Q86TH1 G811R Disease 0.600 0.267 0.00 55 0.690 Q86TH1 P147L Disease 0.439 0.721 0.14 35 0.581 Q86TH1 R113H Disease 0.972 0.865 0.00 59 0.945 Q86TH1 V364I Polymorphism NA 0.117 0.55 -30 0.074 Q86TI0 S14P Polymorphism NA 0.077 NA -32 0.020 Q86TI0 T55I Polymorphism NA 0.065 0.02 5 0.082 Q86TI0 R125W Polymorphism NA 0.245 0.02 29 0.386 Q86TI0 V228G Polymorphism NA 0.078 0.26 -24 0.056 Q86TI0 Y685S Polymorphism NA 0.280 0.39 7 0.342 Q86TN4 F3L Polymorphism NA 0.043 0.63 -12 0.036 Q86TN4 H172R Polymorphism NA 0.254 0.25 1 0.399 Q86TS9 G5V Polymorphism NA 0.249 0.00 34 0.161 Q86TS9 K104R Polymorphism NA 0.026 0.68 11 0.063 Q86TX2 R266H Polymorphism NA 0.251 0.55 -11 0.219 Q86TY3 T96I Polymorphism 0.430 0.090 0.07 20 0.084 Q86TY3 A391V Polymorphism 0.382 0.039 0.98 -20 0.029 Q86TY3 Q613E Polymorphism 0.096 0.066 1.00 -60 0.007 Q86TZ1 T376S Polymorphism 0.455 0.463 0.68 -36 0.148 Q86U06 D184N Polymorphism 0.223 0.659 0.06 -1 0.423 Q86U10 C95R Polymorphism 0.418 0.581 0.51 -47 0.221 Q86U10 L96V Polymorphism 0.336 0.763 0.07 16 0.637 Q86U10 S344R Polymorphism 0.316 0.371 0.50 41 0.433 Q86U38 S308N Polymorphism NA 0.111 0.36 22 0.199 Q86UA6 K103N Polymorphism NA 0.055 0.45 -25 0.039 Q86UC2 E484K Polymorphism 0.131 0.205 NA 4 0.098 Q86UC2 G518D Polymorphism 0.178 0.056 0.37 -26 0.009 Q86UC2 M439T Polymorphism 0.158 0.661 0.21 5 0.323 Q86UC2 R213Q Polymorphism 0.067 0.019 0.77 -25 0.035 Q86UD1 H210R Polymorphism 0.177 0.077 0.76 -13 0.011 Q86UD1 R217H Polymorphism 0.088 0.181 0.30 18 0.110 Q86UD3 R68Q Polymorphism NA 0.030 0.74 -42 0.018 Q86UD4 N182D Polymorphism 0.109 0.238 0.02 3 0.200 Q86UD5 F357C Polymorphism NA 0.239 0.05 -20 0.358 Q86UD5 I159T Polymorphism NA 0.207 0.00 28 0.291 Q86UE3 A253V Polymorphism NA 0.762 0.32 57 0.678 Q86UE3 E427G Polymorphism 0.578 0.281 0.39 18 0.295 Q86UE3 L652F Polymorphism 0.827 0.352 0.10 23 0.553 Q86UE3 Q201R Polymorphism NA 0.621 0.57 3 0.165 Q86UE4 T317A Polymorphism 0.233 0.065 NA -23 0.088 Q86UE6 N330S Polymorphism 0.109 0.267 0.48 -28 0.172 Q86UE8 H6R Polymorphism NA 0.530 0.00 42 0.472 Q86UE8 A95G Polymorphism NA 0.066 0.00 -21 0.030 Q86UE8 E54D Polymorphism NA 0.406 0.01 1 0.419 Q86UE8 R109L Polymorphism NA 0.165 0.00 26 0.072 Q86UE8 R262Q Polymorphism 0.169 0.278 0.08 0 0.206 Q86UG4 A27V Polymorphism NA 0.065 0.06 -23 0.081 Q86UG4 P527A Polymorphism 0.562 0.655 0.62 40 0.511 Q86UK0 E550G Polymorphism NA 0.098 NA 2 0.093 Q86UK0 Q274R Polymorphism NA 0.302 NA 45 0.360 Q86UK0 S459T Polymorphism NA 0.100 NA 6 0.084 Q86UK0 D2365N Disease 0.321 0.489 0.42 -12 0.253 Q86UK0 E1539K Disease 0.970 0.871 0.00 57 0.983 Q86UK0 G1381E Disease 0.995 0.935 0.00 58 0.989 Q86UK0 G1651S Disease 0.972 0.548 0.00 -7 0.746 Q86UK0 N1380S Disease 0.989 0.850 0.13 34 0.861 Q86UK0 R1514H Disease 0.979 0.715 0.00 47 0.952 Q86UK5 I283R Disease 0.193 0.493 0.00 52 0.646 Q86UK5 R950W Disease 0.817 0.210 0.02 28 0.383 Q86UK5 S230G Polymorphism 0.215 0.086 0.43 23 0.060 Q86UK5 T699A Polymorphism 0.084 0.105 0.21 -17 0.034 Q86UK7 A608T Polymorphism 0.155 0.137 0.53 11 0.100 Q86UK7 C725S Polymorphism 0.167 0.174 0.79 30 0.115 Q86UK7 T637M Polymorphism 0.426 0.119 0.06 32 0.123 Q86UQ0 T12A Polymorphism NA 0.084 1.00 -16 0.040 Q86UQ0 T216R Polymorphism 0.157 0.550 0.21 -2 0.149 Q86UQ4 E799K Polymorphism NA 0.186 NA 17 0.120 Q86UQ4 I767S Polymorphism NA 0.153 NA 24 0.128 Q86UQ4 R555H Polymorphism NA 0.075 NA -37 0.018 Q86UQ4 A2178E Polymorphism NA 0.094 NA 30 0.009 Q86UQ4 I1434V Polymorphism NA 0.093 NA -1 0.031 Q86UQ4 I1889K Polymorphism NA 0.150 NA 49 0.132 Q86UQ4 K2436R Polymorphism NA 0.130 NA 11 0.110 Q86UQ4 N2033D Polymorphism NA 0.344 NA 28 0.263 Q86UQ4 N4277D Polymorphism NA 0.256 0.07 -3 0.243 Q86UQ4 S2537A Polymorphism NA 0.072 NA -16 0.009 Q86UQ8 Q116R Polymorphism NA 0.106 NA 40 0.053 Q86UR5 R820H Disease 0.684 0.818 0.42 40 0.806 Q86US8 K294Q Polymorphism 0.302 0.036 0.00 18 0.115 Q86US8 N341T Polymorphism 0.195 0.064 0.25 10 0.034 Q86US8 N575S Polymorphism NA 0.024 0.13 -16 0.032 Q86US8 R291P Polymorphism 0.652 0.257 0.00 36 0.432 Q86US8 H1233R Polymorphism NA 0.030 0.49 20 0.063 Q86UT6 P63S Polymorphism NA 0.114 0.00 14 0.092 Q86UT6 A843S Polymorphism 0.221 0.170 0.75 49 0.148 Q86UV5 S125C Polymorphism NA 0.671 0.11 16 0.720 Q86UV6 W13R Polymorphism 0.104 0.597 0.31 10 0.103 Q86UW6 D611N Polymorphism 0.269 0.027 NA -27 0.011 Q86UW6 M196V Polymorphism NA 0.065 NA 44 0.080 Q86UW6 T1587A Polymorphism NA 0.084 0.02 26 0.141 Q86UW9 A94T Polymorphism NA 0.086 0.13 38 0.164 Q86UW9 G384E Polymorphism 0.126 0.291 0.85 3 0.198 Q86UW9 T421A Polymorphism 0.060 0.056 0.48 -4 0.074 Q86UX2 N207H Polymorphism NA 0.213 0.20 51 0.401 Q86UX2 R629C Polymorphism 0.665 0.402 0.05 25 0.619 Q86UX6 A454T Polymorphism 0.045 0.088 1.00 6 0.080 Q86UX6 E467K Polymorphism 0.040 0.124 1.00 38 0.076 Q86UX6 T334A Polymorphism 0.120 0.110 0.75 -48 0.149 Q86UY8 A266E Polymorphism NA 0.349 1.00 -15 0.186 Q86UZ6 T11A Polymorphism NA 0.329 0.04 -7 0.193 Q86V20 F132L Polymorphism NA 0.050 1.00 -16 0.013 Q86V20 S550C Polymorphism NA 0.182 0.03 35 0.263 Q86V21 I118V Polymorphism 0.128 0.062 0.27 -15 0.122 Q86V24 Q39R Polymorphism NA 0.074 0.72 22 0.061 Q86V42 D181H Polymorphism NA 0.559 0.01 31 0.617 Q86V48 Q461K Polymorphism NA 0.105 0.02 25 0.158 Q86V48 T491I Polymorphism NA 0.128 0.07 4 0.119 Q86V59 S80T Polymorphism 0.278 0.487 0.67 -11 0.324 Q86V87 G667R Polymorphism 0.286 0.841 0.07 0 0.488 Q86V87 T315A Polymorphism 0.361 0.259 0.38 -15 0.219 Q86VD1 D462E Polymorphism 0.272 0.088 0.43 25 0.158 Q86VD1 H836Y Polymorphism 0.083 0.038 0.29 -23 0.045 Q86VD1 K322M Polymorphism 0.492 0.055 0.05 -7 0.128 Q86VD1 M649I Polymorphism 0.158 0.028 0.39 12 0.034 Q86VD1 S767N Polymorphism 0.079 0.025 0.52 -21 0.032 Q86VD1 S982C Polymorphism 0.422 0.173 NA 28 0.066 Q86VD1 T153P Polymorphism 0.783 0.712 0.17 32 0.718 Q86VD7 L312M Polymorphism 0.660 0.330 0.17 -17 0.570 Q86VD9 M487I Polymorphism 0.313 0.168 0.50 22 0.301 Q86VD9 V417A Polymorphism 0.321 0.482 0.21 27 0.425 Q86VF7 A132S Polymorphism 0.151 0.187 0.24 25 0.087 Q86VF7 A282T Polymorphism 0.260 0.158 0.01 14 0.255 Q86VF7 A344T Polymorphism 0.071 0.102 0.07 -28 0.092 Q86VF7 A647S Polymorphism 0.211 0.104 0.07 30 0.262 Q86VF7 A674V Polymorphism 0.164 0.121 0.00 42 0.400 Q86VF7 N519I Polymorphism 0.583 0.106 0.06 30 0.335 Q86VF7 Q186E Polymorphism 0.239 0.082 0.04 20 0.185 Q86VF7 Q360R Polymorphism 0.078 0.091 0.23 29 0.111 Q86VF7 S490L Polymorphism 0.077 0.099 0.00 18 0.204 Q86VF7 V208A Polymorphism 0.062 0.059 1.00 -19 0.031 Q86VF7 Y249C Polymorphism 0.204 0.109 0.01 36 0.312 Q86VF7 L1531P Polymorphism 0.223 0.187 0.16 -28 0.246 Q86VI1 Q561E Polymorphism 0.061 0.078 1.00 1 0.054 Q86VI1 S634G Polymorphism 0.110 0.091 0.48 -21 0.100 Q86VI3 R663C Polymorphism 0.208 0.052 0.04 -3 0.115 Q86VI3 V410L Polymorphism 0.356 0.491 0.00 22 0.510 Q86VL8 G429R Polymorphism 0.917 0.947 0.01 77 0.931 Q86VP1 S58N Polymorphism NA 0.885 0.02 38 0.675 Q86VP1 L307I Polymorphism NA 0.169 0.38 29 0.283 Q86VP3 L493S Polymorphism 0.690 0.793 0.00 44 0.850 Q86VP6 A952V Polymorphism 0.630 0.785 0.00 33 0.713 Q86VP6 V803A Polymorphism 0.374 0.300 0.05 -65 0.269 Q86VQ0 D26A Polymorphism 0.521 0.341 0.00 41 0.501 Q86VQ0 L24S Polymorphism 0.143 0.052 1.00 12 0.029 Q86VQ3 A225P Polymorphism NA 0.064 1.00 34 0.022 Q86VQ3 I314L Polymorphism NA 0.086 0.00 0 0.135 Q86VR8 M153L Polymorphism 0.061 0.171 0.27 8 0.135 Q86VS8 Y670S Polymorphism 0.797 0.815 0.02 29 0.850 Q86VV4 A271V Polymorphism NA 0.627 0.05 -14 0.540 Q86VV8 K245R Polymorphism NA 0.056 NA 24 0.072 Q86VV8 S126A Polymorphism NA 0.042 NA 15 0.070 Q86VV8 H1742R Polymorphism NA 0.341 NA -6 0.458 Q86VW0 Y49F Polymorphism 0.147 0.888 0.01 29 0.701 Q86VW0 V563A Polymorphism 0.401 0.062 0.64 18 0.121 Q86VW1 M409T Polymorphism 0.185 0.472 0.01 46 0.321 Q86VW1 V252A Polymorphism 0.460 0.386 0.04 18 0.406 Q86VW2 G397R Polymorphism NA 0.720 0.10 27 0.573 Q86VW2 Q506R Polymorphism NA 0.221 0.73 4 0.084 Q86VY4 I365V Polymorphism 0.191 0.309 0.14 16 0.264 Q86VY4 T120S Polymorphism NA 0.038 1.00 0 0.050 Q86VZ4 G442R Polymorphism 0.540 0.177 NA 39 0.128 Q86W10 P393L Polymorphism NA 0.564 0.03 4 0.463 Q86W11 Q238P Polymorphism 0.514 0.473 0.04 36 0.570 Q86W24 E21K Polymorphism NA 0.702 0.08 -13 0.526 Q86W24 K92R Polymorphism 0.152 0.302 0.78 -6 0.220 Q86W24 N48T Polymorphism 0.109 0.116 0.82 -50 0.085 Q86W24 S98L Polymorphism 0.138 0.268 0.27 6 0.178 Q86W24 E808K Polymorphism 0.249 0.355 0.20 8 0.326 Q86W24 L511F Polymorphism 0.416 0.597 0.25 31 0.515 Q86W24 L954S Polymorphism 0.088 0.243 0.25 -35 0.156 Q86W24 S951T Polymorphism 0.382 0.466 0.99 -31 0.271 Q86W24 T397I Polymorphism 0.943 0.762 0.00 51 0.921 Q86W24 V441M Polymorphism 0.465 0.416 0.09 26 0.402 Q86W24 L1010F Polymorphism 0.335 0.940 0.04 17 0.435 Q86W25 N781S Polymorphism 0.713 0.734 0.29 31 0.663 Q86W25 Q247R Polymorphism 0.173 0.742 0.42 -9 0.309 Q86W28 P25L Polymorphism NA 0.203 NA 35 0.048 Q86W28 A234T Polymorphism 0.297 0.190 0.29 13 0.321 Q86W28 A543V Polymorphism 0.325 0.221 0.32 15 0.363 Q86W28 K937R Polymorphism 0.210 0.245 0.75 -33 0.157 Q86W28 Q268R Polymorphism 0.271 0.182 0.30 21 0.289 Q86W28 Q367E Polymorphism 0.260 0.194 0.28 4 0.224 Q86W28 R651W Polymorphism 0.812 0.223 0.04 30 0.635 Q86W28 V116L Polymorphism NA 0.156 0.14 -28 0.111 Q86W28 V782A Polymorphism 0.292 0.440 1.00 -1 0.179 Q86W47 V199I Polymorphism 0.151 0.075 0.79 6 0.059 Q86WB0 T271A Polymorphism NA 0.137 0.19 31 0.116 Q86WB7 M403I Polymorphism 0.175 0.126 0.56 -7 0.144 Q86WB7 M403T Polymorphism 0.235 0.058 0.65 -41 0.053 Q86WB7 V292I Polymorphism 0.120 0.116 0.63 -21 0.128 Q86WD7 H236Q Polymorphism 0.142 0.177 0.56 -41 0.093 Q86WD7 V330A Polymorphism 0.110 0.209 0.45 39 0.244 Q86WG3 S301R Disease 0.673 0.708 0.03 35 0.672 Q86WG5 E679K Polymorphism 0.175 0.179 0.16 -22 0.066 Q86WG5 P303L Polymorphism 0.737 0.711 0.02 24 0.760 Q86WG5 Q1216E Polymorphism NA 0.111 0.02 35 0.191 Q86WH2 R232H Polymorphism 0.306 0.310 0.02 -5 0.443 Q86WI1 A957E Polymorphism NA 0.138 0.01 56 0.236 Q86WI1 W373C Polymorphism NA 0.431 0.10 25 0.584 Q86WI1 Y943H Polymorphism NA 0.106 0.00 54 0.238 Q86WI1 H3050Q Polymorphism NA 0.103 0.19 27 0.138 Q86WI1 L3862F Polymorphism NA 0.281 0.03 16 0.341 Q86WI1 T1192A Polymorphism NA 0.159 0.66 22 0.146 Q86WI1 T1539R Polymorphism NA 0.136 NA 16 0.186 Q86WI1 V4220I Polymorphism NA 0.070 0.05 18 0.042 Q86WI3 C500R Polymorphism NA 0.427 0.09 29 0.406 Q86WI3 P453L Polymorphism NA 0.188 0.40 -6 0.244 Q86WI3 S210L Polymorphism NA 0.256 0.01 15 0.376 Q86WI3 Q1105K Polymorphism 0.047 0.236 0.30 48 0.279 Q86WI3 Q1466R Polymorphism 0.187 0.272 0.76 16 0.216 Q86WJ1 E649A Polymorphism 0.085 0.265 0.71 -10 0.190 Q86WN1 N344K Polymorphism 0.090 0.164 0.62 -11 0.134 Q86WR7 A412V Polymorphism 0.144 0.050 0.05 23 0.067 Q86WS5 Y19H Polymorphism NA 0.144 0.37 25 0.023 Q86WS5 A127T Polymorphism NA 0.073 0.73 -1 0.116 Q86WT1 V446I Polymorphism 0.139 0.024 1.00 -46 0.011 Q86WT6 D15N Polymorphism 0.025 0.041 0.65 -11 0.025 Q86WT6 K104R Polymorphism 0.187 0.137 0.49 12 0.150 Q86WT6 T161M Polymorphism 0.097 0.195 0.02 -19 0.135 Q86WV1 S242G Polymorphism 0.434 0.210 0.39 -10 0.307 Q86WV6 R71H Polymorphism NA 0.071 0.59 20 0.053 Q86WV6 H232R Polymorphism NA 0.028 1.00 8 0.017 Q86WV6 R293Q Polymorphism NA 0.305 0.00 38 0.492 Q86X27 N225S Polymorphism 0.181 0.770 0.02 54 0.582 Q86X29 S363N Polymorphism NA 0.158 0.04 -8 0.122 Q86X45 I466T Polymorphism NA 0.500 0.00 8 0.650 Q86X45 T232I Polymorphism 0.155 0.092 0.14 6 0.097 Q86X53 R403S Polymorphism NA 0.130 NA -12 0.097 Q86X67 G81D Polymorphism NA 0.372 0.09 11 0.266 Q86XA0 L141V Polymorphism NA 0.133 0.55 -3 0.186 Q86XD8 H358Y Polymorphism NA 0.108 NA 7 0.101 Q86XD8 K118T Polymorphism 0.134 0.101 0.00 30 0.125 Q86XE0 A282V Polymorphism 0.113 0.715 0.32 21 0.366 Q86XE0 S354Y Polymorphism NA 0.231 0.09 18 0.363 Q86XH1 K452R Polymorphism 0.125 0.238 0.05 -18 0.208 Q86XI2 E867D Polymorphism NA 0.283 NA -2 0.380 Q86XI2 T794M Polymorphism NA 0.142 NA -20 0.085 Q86XI6 G48E Polymorphism 0.349 0.117 0.99 1 0.118 Q86XJ1 P500T Polymorphism NA 0.176 0.07 48 0.194 Q86XK2 T126S Polymorphism 0.085 0.109 NA -17 0.024 Q86XK7 V147I Polymorphism 0.321 0.099 0.92 -53 0.107 Q86XN6 I168V Polymorphism NA 0.133 0.16 20 0.309 Q86XN6 Q603E Polymorphism NA 0.480 1.00 -34 0.105 Q86XN6 S122I Polymorphism NA 0.185 0.23 41 0.416 Q86XN6 S528G Polymorphism 0.836 0.197 1.00 -24 0.031 Q86XN7 S847T Polymorphism NA 0.117 0.10 18 0.113 Q86XP0 A649G Polymorphism 0.391 0.092 1.00 -2 0.094 Q86XP0 P275R Polymorphism NA 0.282 0.06 47 0.403 Q86XP0 R573W Polymorphism 0.834 0.189 0.03 55 0.367 Q86XP0 R747G Polymorphism 0.804 0.818 0.00 43 0.865 Q86XP0 R807Q Polymorphism 0.579 0.353 0.06 57 0.550 Q86XP0 S434T Polymorphism 0.210 0.235 0.96 -15 0.200 Q86XP6 S113N Polymorphism 0.137 0.066 0.08 12 0.025 Q86XQ3 N204K Polymorphism 0.050 0.620 0.47 -8 0.038 Q86XR2 G603S Polymorphism 0.083 0.028 0.79 26 0.076 Q86XR8 R448G Polymorphism 0.073 0.124 0.73 0 0.051 Q86XU0 D56N Polymorphism 0.130 0.153 0.51 -13 0.113 Q86XX4 L466I Polymorphism NA 0.392 0.25 27 0.346 Q86XX4 S429Y Polymorphism NA 0.378 0.35 35 0.424 Q86XX4 E1135K Polymorphism NA 0.227 0.24 41 0.410 Q86XX4 G1022E Polymorphism NA 0.751 1.00 12 0.250 Q86Y07 N50D Polymorphism 0.133 0.278 0.70 22 0.170 Q86Y07 I157M Polymorphism 0.332 0.278 0.13 -28 0.294 Q86Y07 I167V Polymorphism 0.247 0.408 0.28 -18 0.288 Q86Y07 N211S Polymorphism 0.602 0.196 0.61 24 0.412 Q86Y22 T287A Polymorphism 0.128 0.206 0.76 -5 0.147 Q86Y25 F546L Polymorphism 0.096 0.755 0.01 6 0.378 Q86Y26 T781M Polymorphism 0.304 0.075 NA 18 0.037 Q86Y26 T973N Polymorphism 0.468 0.405 0.00 27 0.565 Q86Y26 R1113H Polymorphism NA 0.347 0.04 23 0.371 Q86Y29 R95T Polymorphism NA 0.162 NA 31 0.057 Q86Y30 R95T Polymorphism NA 0.162 0.00 18 0.164 Q86Y33 T8P Polymorphism NA 0.393 NA 47 0.410 Q86Y33 E17K Polymorphism NA 0.335 NA 27 0.256 Q86Y33 R503W Polymorphism 0.315 0.488 0.18 10 0.536 Q86Y34 A430T Polymorphism 0.127 0.213 0.51 33 0.246 Q86Y38 P325R Polymorphism 0.292 0.849 0.22 49 0.616 Q86Y38 V839I Polymorphism NA 0.178 0.23 -5 0.151 Q86Y46 V61M Polymorphism 0.362 0.224 0.26 19 0.329 Q86Y46 E365G Polymorphism 0.487 0.305 0.18 19 0.398 Q86YA3 T978I Polymorphism NA 0.336 NA 32 0.267 Q86YB7 N119D Polymorphism 0.676 0.194 0.88 -27 0.350 Q86YB8 D129V Polymorphism 0.271 0.230 0.22 11 0.308 Q86YC2 P864S Polymorphism NA 0.193 NA 24 0.183 Q86YD3 Q342R Polymorphism NA 0.088 NA -6 0.029 Q86YD7 A234E Polymorphism NA 0.122 1.00 -26 0.015 Q86YD7 P334L Polymorphism NA 0.334 0.03 17 0.216 Q86YD7 R343S Polymorphism NA 0.116 1.00 -22 0.059 Q86YD7 T410A Polymorphism NA 0.060 1.00 -55 0.064 Q86YE8 G166A Polymorphism 0.550 0.609 0.22 14 0.561 Q86YF9 M664L Polymorphism 0.284 0.024 0.69 -10 0.017 Q86YF9 T172M Polymorphism 0.567 0.063 0.06 -7 0.095 Q86YH2 V522G Polymorphism NA 0.304 0.38 14 0.369 Q86YH6 S382L Disease 0.472 0.846 0.00 28 0.842 Q86YJ5 Q257H Polymorphism NA 0.336 0.05 22 0.454 Q86YJ5 T307P Polymorphism NA 0.449 0.07 5 0.305 Q86YJ6 R324G Polymorphism 0.326 0.907 0.00 59 0.900 Q86YJ6 T204N Polymorphism 0.177 0.590 0.26 -53 0.177 Q86YL7 A105G Polymorphism 0.476 0.112 0.10 26 0.108 Q86YN6 A203P Polymorphism 0.365 0.109 0.07 -8 0.108 Q86YN6 R292S Polymorphism 0.412 0.309 0.00 19 0.293 Q86YP4 N296S Polymorphism 0.095 0.236 NA -19 0.164 Q86YR7 F589S Polymorphism 0.112 0.177 0.37 34 0.110 Q86YR7 F772L Polymorphism 0.097 0.378 0.65 -13 0.143 Q86YR7 I359L Polymorphism 0.079 0.114 1.00 -31 0.077 Q86YR7 N277S Polymorphism 0.472 0.073 0.68 -11 0.106 Q86YR7 Q378L Polymorphism 0.089 0.252 0.17 -38 0.190 Q86YR7 T159M Polymorphism 0.090 0.231 0.23 -24 0.183 Q86YR7 M1015T Polymorphism 0.177 0.157 1.00 -2 0.108 Q86YT9 I94N Polymorphism 0.126 0.629 0.06 45 0.600 Q86YT9 I322M Polymorphism NA 0.063 0.07 23 0.028 Q86YT9 V193A Polymorphism 0.058 0.142 0.38 37 0.114 Q86YV5 L122I Polymorphism 0.208 0.123 0.00 24 0.176 Q86YV5 R137G Polymorphism 0.467 0.325 0.00 49 0.165 Q86YV6 E39A Polymorphism NA 0.089 0.44 38 0.061 Q86YV6 C318Y Polymorphism 0.689 0.798 0.08 18 0.667 Q86YV6 Q373R Polymorphism 0.052 0.300 0.52 7 0.173 Q86YV6 T126M Polymorphism NA 0.586 0.04 0 0.357 Q86YW5 H231P Polymorphism NA 0.252 0.11 36 0.150 Q86YZ3 H273Q Polymorphism NA 0.119 0.31 35 0.050 Q86YZ3 R664Q Polymorphism NA 0.038 0.51 14 0.037 Q86YZ3 S799T Polymorphism NA 0.088 0.56 0 0.045 Q86YZ3 G2461S Polymorphism NA 0.080 1.00 28 0.063 Q86Z02 Q6R Polymorphism NA 0.163 0.04 41 0.326 Q86Z02 L1165V Polymorphism NA 0.351 0.00 28 0.310 Q86Z14 Q1020K Polymorphism NA 0.092 1.00 -23 0.035 Q86Z20 V13M Polymorphism NA 0.077 NA 28 0.054 Q8IU68 N306I Polymorphism 0.127 0.355 0.26 -45 0.153 Q8IU68 V501I Polymorphism 0.165 0.092 0.89 -10 0.120 Q8IU80 D521N Disease 0.352 0.746 0.17 17 0.527 Q8IU80 E262K Polymorphism NA 0.126 0.11 35 0.119 Q8IU80 G442R Disease NA 0.295 0.19 -5 0.362 Q8IU80 K253E Polymorphism NA 0.150 1.00 31 0.080 Q8IU80 R774C Disease 0.764 0.377 0.00 44 0.667 Q8IU89 D342G Polymorphism 0.758 0.385 0.43 27 0.606 Q8IUA0 M96T Polymorphism 0.358 0.126 0.55 -5 0.095 Q8IUA0 N137S Polymorphism 0.053 0.048 0.74 -24 0.013 Q8IUA7 N785S Polymorphism 0.329 0.469 0.38 -25 0.317 Q8IUA7 R353H Polymorphism 0.070 0.515 0.57 -20 0.020 Q8IUA7 G1356S Polymorphism 0.351 0.707 0.72 -11 0.183 Q8IUA7 K1306T Polymorphism 0.085 0.488 0.34 39 0.186 Q8IUB2 H36D Polymorphism 0.415 0.091 0.24 20 0.040 Q8IUB2 G198S Polymorphism NA 0.320 0.55 43 0.429 Q8IUB3 L8P Polymorphism NA 0.420 NA -14 0.112 Q8IUC1 C111S Polymorphism 0.518 0.562 0.04 49 0.740 Q8IUC6 R75C Polymorphism NA 0.270 0.00 41 0.175 Q8IUC6 A666T Polymorphism NA 0.093 0.00 31 0.152 Q8IUD2 T1032A Polymorphism 0.024 0.044 0.36 -36 0.009 Q8IUD6 H71Q Polymorphism 0.106 0.094 0.56 -21 0.105 Q8IUD6 R286H Disease 0.239 0.302 0.22 17 0.217 Q8IUD6 S108P Polymorphism 0.275 0.118 0.33 -40 0.087 Q8IUE1 V197I Polymorphism 0.059 0.065 0.37 -21 0.026 Q8IUF8 A17P Polymorphism NA 0.072 0.25 -24 0.070 Q8IUF8 A386T Polymorphism 0.216 0.037 0.33 10 0.076 Q8IUG1 C34S Polymorphism 0.664 0.226 0.45 45 0.384 Q8IUG5 G44E Polymorphism NA 0.054 NA -14 0.011 Q8IUG5 P177L Polymorphism NA 0.072 NA -5 0.047 Q8IUG5 S925L Polymorphism 0.651 0.387 0.13 20 0.520 Q8IUG5 W547C Polymorphism 0.571 0.458 0.19 1 0.474 Q8IUG5 A2294D Polymorphism 0.670 0.141 NA 18 0.207 Q8IUG5 G2395A Polymorphism 0.165 0.177 NA 0 0.049 Q8IUG5 G2513S Polymorphism NA 0.134 NA -32 0.008 Q8IUG5 H1119Q Polymorphism 0.116 0.153 0.41 -1 0.130 Q8IUG5 I1399V Polymorphism 0.133 0.077 0.56 -9 0.117 Q8IUG5 Q2347R Polymorphism 0.126 0.068 NA -8 0.016 Q8IUG5 R2532Q Polymorphism NA 0.137 NA 35 0.175 Q8IUG5 S1390F Polymorphism 0.539 0.492 0.01 -13 0.678 Q8IUG5 S1444T Polymorphism NA 0.148 0.30 -30 0.196 Q8IUG5 W1037S Polymorphism 0.794 0.131 0.70 54 0.185 Q8IUH2 P96Q Polymorphism 0.513 0.157 NA 29 0.057 Q8IUH8 I471V Polymorphism 0.274 0.095 0.70 -15 0.126 Q8IUH8 S601P Polymorphism 0.359 0.113 0.00 24 0.147 Q8IUH8 T659I Polymorphism NA 0.180 NA 38 0.169 Q8IUI8 L389P Polymorphism NA 0.536 0.00 32 0.410 Q8IUN9 C35R Polymorphism NA 0.331 0.00 65 0.261 Q8IUN9 R73K Polymorphism NA 0.308 1.00 0 0.223 Q8IUN9 T100M Polymorphism NA 0.114 0.09 10 0.207 Q8IUR0 S52A Polymorphism 0.191 0.112 0.81 -38 0.177 Q8IUX1 A198V Polymorphism 0.197 0.052 0.45 4 0.056 Q8IUX4 P97L Polymorphism 0.069 0.155 0.66 -17 0.140 Q8IUX4 Q61L Polymorphism 0.217 0.229 0.02 14 0.291 Q8IUX4 R48P Polymorphism NA 0.567 0.37 -27 0.334 Q8IUX4 A108S Polymorphism 0.053 0.151 0.17 -40 0.084 Q8IUX4 A178T Polymorphism 0.318 0.210 0.33 -43 0.198 Q8IUX4 V231I Polymorphism 0.158 0.190 0.16 16 0.247 Q8IUX7 D648E Polymorphism 0.173 0.571 0.85 15 0.255 Q8IUX7 P273T Polymorphism NA 0.108 0.14 27 0.081 Q8IUX7 P1001L Polymorphism 0.801 0.486 0.02 17 0.618 Q8IUX8 D535N Polymorphism 0.507 0.615 0.00 69 0.867 Q8IUX8 L508F Polymorphism 0.273 0.450 0.02 33 0.505 Q8IUX8 R164C Polymorphism 0.721 0.295 0.03 28 0.584 Q8IUZ5 H126R Polymorphism 0.192 0.193 0.53 0 0.168 Q8IV01 N170H Polymorphism 0.067 0.201 0.29 0 0.102 Q8IV03 S62G Polymorphism NA 0.090 0.75 12 0.038 Q8IV20 I254V Polymorphism NA 0.082 0.47 -5 0.154 Q8IV32 Q317L Polymorphism 0.092 0.252 0.28 16 0.128 Q8IV42 G206R Polymorphism 0.093 0.096 0.36 45 0.067 Q8IV50 S164F Polymorphism 0.693 0.216 0.04 0 0.440 Q8IV53 A23T Polymorphism 0.154 0.201 0.13 -19 0.187 Q8IV53 R489C Polymorphism 0.742 0.152 0.00 41 0.469 Q8IV63 F171L Polymorphism NA 0.123 0.59 -23 0.090 Q8IV63 P105T Polymorphism NA 0.122 0.24 0 0.108 Q8IV63 S170P Polymorphism NA 0.268 0.25 -1 0.117 Q8IV63 S371G Polymorphism 0.143 0.448 0.42 50 0.200 Q8IV63 T188A Polymorphism NA 0.129 0.12 -15 0.143 Q8IV76 Q213E Polymorphism NA 0.118 0.00 41 0.181 Q8IVB4 I540V Polymorphism 0.182 0.269 0.53 17 0.244 Q8IVB4 I589V Polymorphism 0.123 0.117 0.07 5 0.048 Q8IVE3 M228V Polymorphism 0.075 0.065 0.28 -15 0.018 Q8IVE3 P481T Polymorphism 0.558 0.088 0.03 32 0.152 Q8IVE3 R1069K Polymorphism 0.477 0.811 0.06 6 0.569 Q8IVF2 A4085V Polymorphism NA 0.084 1.00 -15 0.099 Q8IVF2 D3793N Polymorphism NA 0.164 0.21 1 0.233 Q8IVF2 D4198N Polymorphism NA 0.201 0.38 1 0.256 Q8IVF2 F4138L Polymorphism NA 0.129 0.88 -2 0.116 Q8IVF2 G5564R Polymorphism NA 0.102 NA 27 0.081 Q8IVF2 I4071M Polymorphism NA 0.132 0.30 -10 0.224 Q8IVF2 K2410R Polymorphism NA 0.122 0.34 0 0.234 Q8IVF2 K3902N Polymorphism NA 0.110 0.27 4 0.238 Q8IVF2 K4232N Polymorphism NA 0.129 0.03 5 0.257 Q8IVF2 L3177V Polymorphism NA 0.085 0.57 -22 0.128 Q8IVF2 L4326P Polymorphism NA 0.127 0.08 16 0.245 Q8IVF2 L5028M Polymorphism NA 0.334 0.23 -8 0.247 Q8IVF2 M2107V Polymorphism NA 0.115 1.00 1 0.121 Q8IVF2 M3869V Polymorphism NA 0.096 0.53 -6 0.137 Q8IVF2 M4536L Polymorphism NA 0.210 0.23 -15 0.261 Q8IVF2 P3336L Polymorphism NA 0.170 0.09 15 0.291 Q8IVF2 P5397A Polymorphism NA 0.155 0.13 19 0.241 Q8IVF2 T4664A Polymorphism NA 0.168 0.56 4 0.196 Q8IVF2 V1266M Polymorphism NA 0.127 0.05 2 0.250 Q8IVF2 V2616A Polymorphism NA 0.094 0.51 0 0.218 Q8IVF2 V3363A Polymorphism NA 0.078 0.28 -4 0.186 Q8IVF2 V3796L Polymorphism NA 0.098 0.24 -18 0.224 Q8IVF2 V4278A Polymorphism NA 0.093 0.58 0 0.158 Q8IVF4 S167P Polymorphism NA 0.081 0.27 19 0.088 Q8IVF4 D1767E Polymorphism NA 0.202 1.00 -32 0.159 Q8IVF5 R332H Polymorphism 0.475 0.193 0.02 9 0.383 Q8IVF5 R913H Polymorphism 0.115 0.162 0.00 9 0.148 Q8IVF6 E945D Polymorphism 0.056 0.124 0.51 -33 0.026 Q8IVF6 N484S Polymorphism NA 0.595 0.16 25 0.489 Q8IVF6 Y688C Polymorphism NA 0.331 0.19 9 0.192 Q8IVG5 F289S Polymorphism NA 0.904 NA 27 0.779 Q8IVG5 V266I Polymorphism NA 0.053 NA 12 0.087 Q8IVH4 L89P Disease NA 0.949 0.01 49 0.896 Q8IVH4 G218E Disease 0.235 0.781 0.05 60 0.791 Q8IVH4 R145Q Disease 0.316 0.934 0.17 49 0.858 Q8IVH4 R359G Disease 0.465 0.939 0.00 63 0.935 Q8IVH4 R359Q Disease 0.212 0.931 0.00 56 0.839 Q8IVH4 Y207C Disease 0.957 0.662 0.01 56 0.905 Q8IVL0 S210W Polymorphism NA 0.146 0.00 35 0.263 Q8IVL1 Q491H Polymorphism NA 0.258 0.11 24 0.395 Q8IVL1 E1041D Polymorphism 0.073 0.194 1.00 25 0.124 Q8IVL6 G385E Polymorphism 0.529 0.208 0.02 13 0.349 Q8IVL6 I685T Polymorphism 0.059 0.140 0.25 -11 0.059 Q8IVL6 T301A Polymorphism 0.101 0.167 0.06 -30 0.158 Q8IVL8 M85I Polymorphism 0.074 0.661 0.42 -16 0.036 Q8IVL8 S134R Polymorphism 0.224 0.578 0.57 -4 0.209 Q8IVM0 L121F Polymorphism NA 0.043 0.00 3 0.137 Q8IVM0 M156T Polymorphism 0.230 0.040 0.46 17 0.084 Q8IVS2 A303G Polymorphism 0.325 0.197 0.44 -16 0.235 Q8IVS8 L170V Polymorphism 0.152 0.685 0.09 -14 0.264 Q8IVS8 T394I Polymorphism 0.235 0.258 0.36 -32 0.215 Q8IVT2 E653G Polymorphism NA 0.130 0.42 -1 0.035 Q8IVT2 S156G Polymorphism NA 0.051 0.77 -30 0.031 Q8IVT5 V357A Polymorphism NA 0.251 0.29 15 0.363 Q8IVU3 C199R Polymorphism 0.156 0.651 0.06 50 0.460 Q8IVU3 F343L Polymorphism 0.177 0.223 1.00 -4 0.172 Q8IVU3 M123T Polymorphism 0.151 0.468 0.18 26 0.070 Q8IVV2 D398G Polymorphism 0.414 0.348 0.12 17 0.374 Q8IVV2 V547M Polymorphism 0.437 0.628 0.12 48 0.617 Q8IVV2 T1105M Polymorphism 0.350 0.221 0.06 40 0.377 Q8IVV8 C151G Polymorphism 0.323 0.229 0.42 -1 0.036 Q8IVW1 L170I Polymorphism NA 0.186 0.34 -17 0.113 Q8IVW4 M394T Polymorphism NA 0.206 0.55 25 0.214 Q8IVY1 S12L Polymorphism NA 0.138 NA 20 0.120 Q8IW00 F68S Polymorphism NA 0.157 NA 0 0.008 Q8IW19 I100V Polymorphism 0.077 0.034 1.00 -32 0.014 Q8IW19 L336F Polymorphism 0.307 0.035 0.52 -31 0.042 Q8IW36 R84K Polymorphism 0.312 0.295 1.00 -39 0.263 Q8IW36 V87A Polymorphism 0.315 0.125 0.59 -20 0.142 Q8IW41 M67I Polymorphism 0.146 0.320 0.40 -1 0.156 Q8IW41 R282K Polymorphism 0.163 0.323 1.00 -26 0.221 Q8IW45 K140E Polymorphism 0.250 0.687 1.00 -36 0.313 Q8IW45 V149I Polymorphism 0.590 0.562 0.06 6 0.526 Q8IW75 Q142K Polymorphism 0.293 0.263 1.00 -22 0.172 Q8IWA4 P523R Polymorphism 0.620 0.073 1.00 0 0.026 Q8IWA6 I46V Polymorphism NA 0.114 NA -11 0.100 Q8IWA6 V393I Polymorphism NA 0.164 NA -15 0.078 Q8IWB6 D88G Polymorphism 0.366 0.566 0.05 38 0.526 Q8IWB6 I559M Polymorphism 0.461 0.238 0.00 25 0.394 Q8IWB6 S443C Polymorphism 0.621 0.500 0.01 55 0.609 Q8IWC1 E502A Polymorphism 0.287 0.034 0.15 -17 0.014 Q8IWC1 Q628R Polymorphism 0.279 0.040 0.43 0 0.051 Q8IWD4 R147S Polymorphism NA 0.324 NA 47 0.367 Q8IWD5 R486H Polymorphism NA 0.092 0.16 35 0.079 Q8IWE2 G84R Polymorphism 0.132 0.252 0.00 31 0.170 Q8IWE2 S40L Polymorphism 0.487 0.143 0.00 -8 0.039 Q8IWE2 L116P Polymorphism 0.079 0.124 0.11 -40 0.025 Q8IWE2 P201L Polymorphism 0.293 0.140 0.98 4 0.208 Q8IWE5 I32T Polymorphism NA 0.060 0.03 -25 0.011 Q8IWF2 K374R Polymorphism NA 0.072 0.72 -46 0.063 Q8IWF9 T49A Polymorphism 0.199 0.048 0.44 -10 0.046 Q8IWG1 T674A Polymorphism 0.151 0.284 0.45 -35 0.091 Q8IWI9 S716T Polymorphism NA 0.081 NA 14 0.077 Q8IWI9 T338A Polymorphism 0.205 0.113 0.00 29 0.143 Q8IWI9 C1270R Polymorphism NA 0.235 NA 39 0.219 Q8IWI9 P1523A Polymorphism NA 0.157 0.01 40 0.257 Q8IWK6 V1166G Polymorphism 0.508 0.114 0.34 -15 0.067 Q8IWL1 N9T Polymorphism 0.109 0.054 1.00 -69 0.034 Q8IWL1 V50L Polymorphism 0.120 0.116 0.32 -17 0.100 Q8IWL2 N9T Polymorphism 0.109 0.054 1.00 -73 0.040 Q8IWL2 L50V Polymorphism 0.120 0.371 1.00 -20 0.070 Q8IWL2 V19A Polymorphism 0.093 0.026 0.66 -47 0.018 Q8IWL3 Y73C Polymorphism NA 0.883 0.00 59 0.917 Q8IWL3 I163M Polymorphism NA 0.083 1.00 -49 0.057 Q8IWL8 Q7R Polymorphism NA 0.066 NA 9 0.049 Q8IWN7 A487V Polymorphism NA 0.058 0.00 21 0.153 Q8IWN7 E795K Polymorphism 0.312 0.027 0.23 7 0.022 Q8IWN7 H222P Polymorphism 0.360 0.519 0.20 28 0.687 Q8IWN7 R136H Polymorphism 0.156 0.113 0.06 -17 0.098 Q8IWN7 R860W Polymorphism 0.840 0.196 0.01 -6 0.221 Q8IWN7 T112S Polymorphism 0.390 0.118 0.16 23 0.201 Q8IWN7 A1285S Polymorphism 0.516 0.072 0.50 14 0.041 Q8IWN7 A1563V Polymorphism 0.384 0.110 0.10 32 0.096 Q8IWN7 A1789V Polymorphism 0.210 0.171 0.01 18 0.200 Q8IWN7 E1340G Polymorphism 0.226 0.032 0.13 37 0.025 Q8IWN7 E2171K Polymorphism 0.289 0.053 0.48 48 0.090 Q8IWN7 E2220K Polymorphism 0.126 0.076 0.47 41 0.069 Q8IWN7 E2251K Polymorphism 0.124 0.076 0.66 45 0.059 Q8IWN7 G1335R Polymorphism 0.483 0.162 0.01 47 0.238 Q8IWN7 G1420E Polymorphism 0.096 0.056 0.01 22 0.044 Q8IWN7 G1896D Polymorphism 0.481 0.074 0.40 48 0.081 Q8IWN7 G2365R Polymorphism NA 0.144 0.26 40 0.149 Q8IWN7 H2415R Polymorphism NA 0.103 0.21 23 0.073 Q8IWN7 Q2168H Polymorphism 0.333 0.106 0.02 39 0.138 Q8IWP9 S42Y Polymorphism NA 0.076 NA 33 0.034 Q8IWR0 H57R Polymorphism 0.055 0.095 0.04 -2 0.035 Q8IWS0 C45Y Disease NA 0.960 0.00 66 0.928 Q8IWS0 C99F Disease NA 0.948 0.00 71 0.927 Q8IWS0 H229R Disease NA 0.181 0.57 0 0.233 Q8IWS0 K234E Disease 0.272 0.134 0.99 7 0.068 Q8IWS0 R257G Disease 0.501 0.475 0.11 40 0.638 Q8IWT1 L179F Disease 0.326 0.168 0.10 -11 0.103 Q8IWU2 P30A Polymorphism NA 0.113 0.02 19 0.156 Q8IWU2 I693T Polymorphism NA 0.089 0.00 21 0.128 Q8IWU2 V595I Polymorphism NA 0.117 0.08 13 0.114 Q8IWU2 V624M Polymorphism NA 0.083 0.00 41 0.164 Q8IWU2 A1341G Polymorphism NA 0.174 0.37 16 0.128 Q8IWU2 D1061N Polymorphism NA 0.059 0.00 36 0.149 Q8IWU2 S1401N Polymorphism NA 0.072 0.12 -16 0.088 Q8IWU9 L36V Polymorphism 0.201 0.117 0.68 -23 0.089 Q8IWU9 A328V Polymorphism 0.814 0.500 0.31 19 0.730 Q8IWU9 D479E Polymorphism 0.169 0.403 0.31 -40 0.234 Q8IWV7 H136R Disease 0.974 0.941 0.00 60 0.963 Q8IWV7 G1279S Disease 0.217 0.069 0.74 17 0.074 Q8IWV8 A1095S Polymorphism 0.233 0.051 0.62 -42 0.071 Q8IWW8 C449R Polymorphism 0.419 0.405 1.00 9 0.176 Q8IWX7 A199V Polymorphism 0.612 0.241 0.00 38 0.546 Q8IWX7 I852N Polymorphism NA 0.468 0.00 6 0.480 Q8IWX7 K377R Polymorphism 0.095 0.051 1.00 -38 0.059 Q8IWY4 G398R Polymorphism 0.077 0.847 0.08 34 0.273 Q8IWY4 S648P Polymorphism 0.151 0.418 0.27 -4 0.206 Q8IWY8 R104G Polymorphism NA 0.126 1.00 6 0.127 Q8IWY9 E698K Disease NA 0.629 0.13 40 0.509 Q8IWY9 F868I Disease NA 0.809 0.00 27 0.761 Q8IWY9 N599S Disease NA 0.132 0.00 5 0.143 Q8IWY9 P672L Disease NA 0.682 0.00 21 0.536 Q8IWY9 Q107L Polymorphism NA 0.075 0.00 -10 0.020 Q8IWY9 Q596R Polymorphism NA 0.062 0.61 -8 0.030 Q8IWY9 R714W Disease NA 0.356 0.06 40 0.448 Q8IWY9 V869M Disease NA 0.554 0.00 54 0.724 Q8IWY9 D1043V Disease NA 0.293 NA 20 0.416 Q8IWY9 P1130L Disease NA 0.483 NA 24 0.549 Q8IWY9 R1042W Disease NA 0.355 NA 45 0.535 Q8IWZ3 L175M Polymorphism NA 0.572 0.03 22 0.612 Q8IWZ3 G1586S Polymorphism NA 0.078 1.00 11 0.044 Q8IWZ3 N1760S Polymorphism 0.332 0.209 0.01 27 0.244 Q8IWZ5 V475M Polymorphism 0.319 0.037 0.03 -27 0.101 Q8IWZ6 I66F Disease NA 0.589 NA 44 0.727 Q8IWZ6 H323R Disease NA 0.078 NA -10 0.083 Q8IWZ6 T211I Disease NA 0.661 NA 45 0.711 Q8IWZ8 Q568H Polymorphism 0.482 0.527 0.02 53 0.727 Q8IX01 M552T Polymorphism 0.266 0.041 NA -25 0.007 Q8IX01 Q649R Polymorphism 0.107 0.074 NA -16 0.031 Q8IX01 Q722R Polymorphism 0.111 0.073 0.07 -1 0.046 Q8IX01 R881Q Polymorphism 0.274 0.073 0.02 -2 0.053 Q8IX03 R250C Polymorphism NA 0.210 0.03 25 0.359 Q8IX12 T588I Polymorphism 0.270 0.172 0.26 -19 0.283 Q8IX19 I167V Polymorphism NA 0.153 NA -10 0.133 Q8IX19 L175V Polymorphism NA 0.059 NA 10 0.063 Q8IX21 S541Y Polymorphism NA 0.240 0.04 24 0.175 Q8IX29 R75Q Polymorphism 0.390 0.035 0.43 -12 0.054 Q8IX29 T255N Polymorphism NA 0.252 NA -40 0.142 Q8IX90 D335E Polymorphism NA 0.331 0.08 25 0.167 Q8IXB1 D76N Polymorphism 0.115 0.409 0.24 -22 0.062 Q8IXB1 L347I Polymorphism 0.201 0.351 0.20 20 0.233 Q8IXB1 Y414C Polymorphism 0.740 0.455 0.18 41 0.620 Q8IXB3 H3Y Polymorphism NA 0.053 0.07 -10 0.062 Q8IXB3 A18T Polymorphism NA 0.038 0.69 -17 0.039 Q8IXB3 F20S Polymorphism NA 0.143 0.87 9 0.104 Q8IXB3 S57G Polymorphism 0.432 0.018 1.00 -13 0.007 Q8IXE1 C260R Polymorphism 0.180 0.500 1.00 35 0.187 Q8IXE1 N191D Polymorphism 0.097 0.171 1.00 13 0.120 Q8IXE1 S234T Polymorphism 0.224 0.354 0.60 25 0.345 Q8IXH8 P479L Polymorphism 0.593 0.285 0.13 42 0.588 Q8IXH8 R301G Polymorphism 0.055 0.472 0.10 27 0.106 Q8IXH8 V615L Polymorphism 0.068 0.180 0.61 -56 0.083 Q8IXI1 R425C Polymorphism NA 0.500 0.01 62 0.844 Q8IXJ9 L983R Polymorphism 0.497 0.567 0.03 37 0.708 Q8IXJ9 V751I Polymorphism 0.125 0.034 0.59 -42 0.020 Q8IXJ9 L1325F Polymorphism 0.451 0.096 NA 18 0.087 Q8IXK0 V475M Polymorphism 0.276 0.048 0.24 34 0.055 Q8IXQ6 I517V Polymorphism 0.112 0.125 0.20 14 0.120 Q8IXQ6 T651A Polymorphism 0.217 0.097 0.32 3 0.162 Q8IXQ6 Y528C Polymorphism 0.064 0.109 0.06 -31 0.031 Q8IXS0 M442V Polymorphism 0.323 0.106 0.00 21 0.158 Q8IXS0 Q309P Polymorphism 0.673 0.254 0.00 -5 0.372 Q8IXS2 H133R Polymorphism 0.265 0.063 0.73 -28 0.033 Q8IXT1 D757N Polymorphism NA 0.227 NA 41 0.380 Q8IXT1 R460S Polymorphism NA 0.206 NA 50 0.106 Q8IXT1 V842I Polymorphism NA 0.037 NA -25 0.011 Q8IXT5 S250F Polymorphism 0.297 0.422 0.17 31 0.435 Q8IXY8 H110R Polymorphism NA 0.134 0.07 7 0.137 Q8IXZ2 P351L Polymorphism NA 0.089 0.00 12 0.158 Q8IXZ2 R168W Polymorphism NA 0.058 0.00 19 0.131 Q8IXZ2 S399G Polymorphism NA 0.038 0.00 -34 0.031 Q8IY17 A403P Polymorphism NA 0.084 0.27 -24 0.107 Q8IY17 R929H Disease NA 0.494 0.33 -18 0.457 Q8IY17 M1051V Disease 0.316 0.394 0.02 48 0.315 Q8IY21 I998V Polymorphism NA 0.134 0.14 -23 0.114 Q8IY21 V672M Polymorphism NA 0.138 0.00 -53 0.063 Q8IY26 M8T Polymorphism NA 0.029 0.06 26 0.046 Q8IY26 S7G Polymorphism NA 0.052 0.04 32 0.045 Q8IY26 S140W Polymorphism 0.360 0.834 0.00 41 0.749 Q8IY33 A480P Polymorphism NA 0.081 0.23 -32 0.013 Q8IY33 P519L Polymorphism NA 0.155 0.03 24 0.168 Q8IY37 K508N Polymorphism NA 0.148 0.07 11 0.145 Q8IY37 R458Q Polymorphism 0.678 0.274 0.18 23 0.568 Q8IY37 V717I Polymorphism 0.671 0.061 1.00 -52 0.080 Q8IY47 L534I Polymorphism 0.298 0.736 0.62 -3 0.406 Q8IY47 P254R Polymorphism 0.623 0.849 0.53 55 0.684 Q8IY47 Q166K Polymorphism 0.220 0.482 0.61 48 0.447 Q8IY51 A432T Polymorphism 0.242 0.059 0.51 -47 0.074 Q8IY82 N581K Polymorphism NA 0.339 0.00 0 0.427 Q8IY84 E64Q Polymorphism NA 0.344 0.59 21 0.290 Q8IY84 R21W Polymorphism NA 0.183 0.02 39 0.222 Q8IY84 L260I Polymorphism 0.346 0.067 1.00 -25 0.049 Q8IY84 M320I Polymorphism 0.143 0.369 0.36 -15 0.235 Q8IY85 V312I Polymorphism 0.150 0.037 NA 3 0.038 Q8IY92 A1221V Polymorphism 0.341 0.046 NA 3 0.078 Q8IY92 A1367T Polymorphism 0.224 0.134 NA -9 0.049 Q8IY92 P1677S Polymorphism 0.128 0.048 NA 14 0.049 Q8IYA6 L19F Polymorphism NA 0.101 0.00 50 0.333 Q8IYA6 I375V Polymorphism 0.053 0.075 0.89 -7 0.036 Q8IYA6 L614S Polymorphism 0.075 0.161 0.75 -43 0.069 Q8IYA6 P379A Polymorphism 0.414 0.150 0.18 24 0.123 Q8IYB3 R170H Polymorphism 0.421 0.194 0.06 12 0.228 Q8IYB5 A212V Polymorphism 0.252 0.146 0.14 -11 0.136 Q8IYB7 P12S Polymorphism NA 0.129 NA -42 0.024 Q8IYB8 P30T Polymorphism NA 0.093 0.19 -5 0.067 Q8IYD1 P23T Polymorphism 0.062 0.106 0.00 -31 0.118 Q8IYD8 V878L Polymorphism NA 0.059 0.00 -30 0.036 Q8IYD8 P1812A Polymorphism 0.423 0.177 0.00 -15 0.201 Q8IYD9 C196F Polymorphism NA 0.276 0.00 40 0.371 Q8IYE0 N345S Polymorphism NA 0.037 0.70 6 0.061 Q8IYF1 R179P Polymorphism 0.508 0.175 0.06 -2 0.065 Q8IYF3 K130R Polymorphism NA 0.104 NA 18 0.032 Q8IYG6 R507G Polymorphism 0.129 0.046 0.67 4 0.026 Q8IYI0 A23V Polymorphism NA 0.031 NA -29 0.028 Q8IYI8 L43I Polymorphism 0.068 0.669 0.12 6 0.065 Q8IYI8 P88R Polymorphism 0.162 0.383 0.70 16 0.255 Q8IYK2 D434E Polymorphism NA 0.098 0.62 -40 0.032 Q8IYK2 V245M Polymorphism NA 0.034 0.00 -26 0.041 Q8IYL2 R352G Polymorphism 0.177 0.169 0.38 -2 0.078 Q8IYL3 A101S Polymorphism NA 0.240 0.00 5 0.164 Q8IYL9 I231L Polymorphism 0.164 0.205 0.13 -10 0.210 Q8IYM0 E553Q Polymorphism NA 0.166 NA -7 0.115 Q8IYM1 Q213R Polymorphism 0.158 0.368 0.47 -23 0.154 Q8IYM2 C168R Polymorphism NA 0.301 0.45 34 0.258 Q8IYM2 S448P Polymorphism 0.431 0.728 0.05 2 0.527 Q8IYM9 D155N Polymorphism 0.158 0.084 0.42 35 0.170 Q8IYM9 R321K Polymorphism 0.217 0.176 0.20 44 0.264 Q8IYN0 M8V Polymorphism NA 0.092 1.00 -18 0.031 Q8IYP9 H132N Polymorphism NA 0.401 0.84 48 0.580 Q8IYP9 H274R Polymorphism 0.995 0.901 0.13 78 0.959 Q8IYP9 T221A Polymorphism NA 0.090 0.60 4 0.098 Q8IYQ7 A248E Polymorphism NA 0.305 0.32 0 0.444 Q8IYQ7 L154P Polymorphism NA 0.762 0.00 55 0.875 Q8IYQ7 Q399R Polymorphism NA 0.307 0.19 -1 0.197 Q8IYR0 G170A Polymorphism 0.107 0.171 0.88 -19 0.098 Q8IYR2 I374M Polymorphism NA 0.066 0.01 -14 0.083 Q8IYR2 N101D Polymorphism NA 0.234 0.35 -11 0.255 Q8IYR2 P382R Polymorphism NA 0.055 0.00 46 0.151 Q8IYS0 L644P Polymorphism 0.513 0.836 0.00 54 0.893 Q8IYS1 K333E Polymorphism NA 0.319 0.49 -29 0.188 Q8IYS4 A241V Polymorphism NA 0.039 0.11 13 0.059 Q8IYS4 P143S Polymorphism NA 0.064 0.27 -6 0.034 Q8IYS4 S190L Polymorphism NA 0.091 0.85 30 0.061 Q8IYT1 N22D Polymorphism 0.349 0.192 0.13 56 0.411 Q8IYT1 G319D Polymorphism 0.253 0.284 1.00 16 0.176 Q8IYT1 N551D Polymorphism NA 0.022 1.00 -34 0.009 Q8IYT1 T577M Polymorphism NA 0.046 0.26 -51 0.029 Q8IYT2 L60F Polymorphism 0.315 0.024 0.19 -35 0.056 Q8IYT2 F753L Polymorphism 0.131 0.061 1.00 -35 0.008 Q8IYT2 N416S Polymorphism 0.203 0.044 0.07 -26 0.084 Q8IYT3 A269V Polymorphism 0.377 0.067 0.27 -19 0.070 Q8IYT3 A331T Polymorphism 0.204 0.189 0.57 -39 0.173 Q8IYT3 F324S Polymorphism 0.227 0.166 0.29 -19 0.056 Q8IYT3 V604I Polymorphism 0.390 0.054 0.38 18 0.106 Q8IYT3 V683I Polymorphism 0.221 0.033 0.29 -41 0.028 Q8IYT4 S160N Polymorphism NA 0.209 0.36 -11 0.180 Q8IYT8 D842E Polymorphism NA 0.120 1.00 -33 0.076 Q8IYT8 G752R Polymorphism NA 0.307 0.03 32 0.500 Q8IYT8 P242S Polymorphism 0.336 0.261 0.50 14 0.369 Q8IYU2 R17H Polymorphism 0.117 0.352 0.07 -24 0.263 Q8IYU2 I374T Polymorphism 0.129 0.262 0.37 40 0.113 Q8IYU4 D92V Polymorphism 0.819 0.984 0.00 53 0.931 Q8IYU4 G259D Polymorphism 0.487 0.654 0.26 33 0.753 Q8IYU4 Q143K Polymorphism 0.250 0.341 0.86 18 0.425 Q8IYW5 E413K Polymorphism 0.292 0.016 0.01 -8 0.059 Q8IYW5 P401Q Polymorphism 0.126 0.112 0.01 27 0.135 Q8IYX0 C223S Polymorphism 0.486 0.288 0.40 -3 0.206 Q8IYX0 Y212H Polymorphism 0.906 0.341 0.08 40 0.653 Q8IYX1 R113Q Polymorphism NA 0.169 0.59 46 0.253 Q8IYX3 R122W Polymorphism NA 0.303 0.03 50 0.345 Q8IYX7 K27E Polymorphism NA 0.119 0.00 37 0.158 Q8IYX7 N385S Polymorphism NA 0.099 0.71 5 0.082 Q8IYY4 A551V Polymorphism 0.337 0.014 0.52 -14 0.040 Q8IYY4 K645E Polymorphism 0.254 0.180 0.95 11 0.124 Q8IYY4 R321W Polymorphism 0.498 0.079 0.01 25 0.057 Q8IZ02 L241I Polymorphism 0.316 0.120 0.34 1 0.242 Q8IZ02 M360I Polymorphism 0.068 0.165 0.23 22 0.118 Q8IZ07 L505P Polymorphism 0.205 0.325 0.27 -2 0.216 Q8IZ08 Q5P Polymorphism NA 0.130 0.04 4 0.095 Q8IZ08 V481A Polymorphism 0.163 0.059 0.00 -18 0.101 Q8IZ13 A523S Polymorphism 0.082 0.032 0.60 0 0.035 Q8IZ20 G22V Polymorphism NA 0.165 NA 39 0.178 Q8IZ20 H53R Polymorphism NA 0.150 NA 21 0.024 Q8IZ20 H204N Polymorphism NA 0.149 0.24 58 0.156 Q8IZ40 T514A Polymorphism 0.228 0.063 0.83 0 0.032 Q8IZ57 H104Y Polymorphism NA 0.204 0.39 26 0.319 Q8IZ83 E110K Polymorphism 0.065 0.631 0.19 2 0.023 Q8IZC4 K101T Polymorphism 0.612 0.123 0.51 19 0.126 Q8IZC6 A265T Polymorphism NA 0.171 NA -16 0.173 Q8IZC6 A422T Polymorphism NA 0.061 NA -71 0.068 Q8IZC6 I537T Polymorphism NA 0.065 NA -56 0.029 Q8IZC6 I611F Polymorphism NA 0.401 NA -65 0.286 Q8IZC6 P720R Polymorphism 0.601 0.495 NA 46 0.579 Q8IZC6 Q120R Polymorphism NA 0.161 NA -48 0.050 Q8IZC6 R349C Polymorphism NA 0.150 NA 23 0.142 Q8IZC6 P1116Q Polymorphism 0.641 0.373 NA 36 0.587 Q8IZC6 R1354Q Polymorphism 0.395 0.792 NA -12 0.189 Q8IZC7 M121L Polymorphism 0.060 0.197 0.24 -8 0.100 Q8IZD4 N195D Polymorphism 0.323 0.194 0.50 7 0.286 Q8IZD4 N216S Polymorphism 0.178 0.029 0.55 -32 0.041 Q8IZD6 P349Q Polymorphism 0.145 0.608 0.00 52 0.615 Q8IZF2 T604M Polymorphism NA 0.111 0.11 19 0.054 Q8IZF2 V801I Polymorphism NA 0.101 0.46 -29 0.137 Q8IZF3 R507C Polymorphism 0.714 0.769 0.08 53 0.882 Q8IZF5 A404T Polymorphism NA 0.111 0.11 -18 0.041 Q8IZF6 I276M Polymorphism NA 0.236 NA 38 0.366 Q8IZF6 P368H Polymorphism NA 0.221 NA 38 0.417 Q8IZF6 S1540P Polymorphism NA 0.257 NA 44 0.423 Q8IZF7 I467V Polymorphism 0.148 0.241 0.48 7 0.242 Q8IZJ0 T10M Polymorphism NA 0.030 0.43 20 0.019 Q8IZJ1 I242V Polymorphism 0.222 0.194 0.90 17 0.263 Q8IZJ3 D539E Polymorphism NA 0.067 0.21 19 0.124 Q8IZJ3 V1156I Polymorphism 0.117 0.076 1.00 10 0.090 Q8IZJ4 R37C Polymorphism 0.761 0.450 0.00 40 0.452 Q8IZJ4 D358V Polymorphism 0.276 0.556 0.01 10 0.680 Q8IZJ4 E297K Polymorphism 0.315 0.811 0.21 40 0.563 Q8IZJ4 V378A Polymorphism NA 0.267 0.53 14 0.144 Q8IZK6 K370Q Polymorphism 0.616 0.690 0.03 21 0.575 Q8IZL9 S86L Polymorphism 0.313 0.399 0.66 -15 0.212 Q8IZL9 A137T Polymorphism 0.175 0.201 0.38 4 0.204 Q8IZL9 K281R Polymorphism NA 0.292 0.19 -36 0.209 Q8IZL9 S106N Polymorphism 0.228 0.607 0.38 -11 0.389 Q8IZN3 T334M Polymorphism 0.951 0.120 0.15 39 0.434 Q8IZP6 V92M Polymorphism NA 0.399 0.10 41 0.582 Q8IZP9 H290Q Polymorphism NA 0.044 0.09 -22 0.019 Q8IZP9 N771S Polymorphism 0.314 0.352 0.23 34 0.377 Q8IZS5 R123Q Polymorphism NA 0.040 NA 29 0.019 Q8IZS5 T145I Polymorphism NA 0.105 NA 16 0.043 Q8IZS6 I67V Polymorphism 0.133 0.096 0.37 -24 0.057 Q8IZT6 I313V Polymorphism NA 0.056 0.54 8 0.070 Q8IZT6 T869S Polymorphism NA 0.127 0.50 -30 0.130 Q8IZT6 H3258R Polymorphism NA 0.111 0.19 26 0.108 Q8IZT6 Q2620H Polymorphism NA 0.081 0.10 44 0.146 Q8IZT8 I247N Polymorphism 0.263 0.641 0.19 6 0.555 Q8IZU2 A1215T Polymorphism NA 0.168 NA 25 0.148 Q8IZU2 A1295T Polymorphism NA 0.132 NA -4 0.066 Q8IZU8 P673S Polymorphism NA 0.041 0.67 -52 0.005 Q8IZU9 R40W Disease NA 0.306 0.04 41 0.490 Q8IZU9 R336Q Disease NA 0.384 0.53 52 0.329 Q8IZU9 V731F Disease 0.115 0.180 0.35 23 0.036 Q8IZX4 Q171E Polymorphism 0.154 0.040 0.00 -23 0.075 Q8IZX4 I1411V Polymorphism 0.335 0.244 0.07 10 0.260 Q8IZX4 K1038N Polymorphism 0.802 0.416 0.01 25 0.542 Q8IZX4 K1731N Polymorphism 0.270 0.227 0.25 19 0.138 Q8IZX4 P1389S Polymorphism 0.542 0.293 0.45 17 0.497 Q8IZX4 R1016C Polymorphism 0.967 0.553 0.00 38 0.755 Q8IZX4 R1356C Polymorphism 0.863 0.352 0.00 47 0.613 Q8IZX4 T1169I Polymorphism 0.471 0.157 0.16 5 0.265 Q8IZX4 V1312L Polymorphism 0.331 0.249 0.07 22 0.275 Q8N0S2 E132D Polymorphism 0.157 0.068 0.18 6 0.113 Q8N0S2 P317A Polymorphism 0.126 0.046 0.29 -35 0.020 Q8N0S6 I117F Polymorphism NA 0.279 0.26 -32 0.092 Q8N0U4 G60A Polymorphism NA 0.036 NA -44 0.013 Q8N0U7 K403E Polymorphism NA 0.037 NA -8 0.029 Q8N0U7 L185V Polymorphism NA 0.160 NA 11 0.152 Q8N0U7 N301D Polymorphism NA 0.091 NA 16 0.055 Q8N0V4 R444Q Polymorphism 0.376 0.225 0.06 40 0.417 Q8N0W3 P701L Polymorphism NA 0.565 0.02 31 0.501 Q8N0W3 R939Q Polymorphism NA 0.293 0.12 16 0.440 Q8N0W3 V146M Polymorphism NA 0.162 0.01 13 0.156 Q8N0W3 V861M Polymorphism NA 0.219 0.11 4 0.089 Q8N0W5 L220P Polymorphism NA 0.624 NA 36 0.737 Q8N0X2 Q361H Polymorphism 0.090 0.247 0.50 -49 0.029 Q8N0X4 V128I Polymorphism NA 0.061 0.53 -13 0.125 Q8N0Y3 L61F Polymorphism 0.137 0.168 1.00 -52 0.096 Q8N0Y3 L86F Polymorphism 0.087 0.701 0.41 -5 0.222 Q8N0Y3 T239M Polymorphism 0.361 0.931 0.02 57 0.919 Q8N0Y5 K139N Polymorphism 0.311 0.713 0.15 16 0.461 Q8N0Y7 R40C Polymorphism 0.784 0.791 0.05 21 0.741 Q8N0Y7 R90Q Polymorphism 0.721 0.900 0.00 60 0.910 Q8N0Z3 R472G Polymorphism NA 0.155 0.15 29 0.052 Q8N0Z6 Q47R Polymorphism NA 0.013 0.21 -20 0.021 Q8N0Z8 R103Q Polymorphism NA 0.411 0.03 -20 0.210 Q8N114 G216R Polymorphism NA 0.331 0.13 42 0.377 Q8N119 A311T Polymorphism 0.220 0.162 0.60 -8 0.118 Q8N119 D263E Polymorphism 0.282 0.754 0.00 0 0.536 Q8N119 P115Q Polymorphism 0.675 0.908 0.00 -1 0.856 Q8N127 Y310C Polymorphism 0.356 0.520 0.15 44 0.562 Q8N130 R67H Polymorphism 0.110 0.125 0.35 -9 0.172 Q8N130 A413E Disease 0.469 0.746 0.00 59 0.839 Q8N130 G180A Polymorphism 0.800 0.450 0.00 21 0.547 Q8N130 G196R Disease 0.648 0.721 0.13 32 0.839 Q8N130 R353L Disease 0.484 0.635 0.03 30 0.590 Q8N130 R468W Disease 0.965 0.926 0.00 57 0.969 Q8N130 S138F Disease 0.880 0.652 0.01 49 0.851 Q8N130 S192L Disease 0.465 0.573 0.01 16 0.693 Q8N131 V71M Polymorphism 0.550 0.051 0.18 29 0.066 Q8N131 V86F Polymorphism 0.453 0.146 0.06 39 0.140 Q8N136 T27I Polymorphism NA 0.307 0.11 37 0.399 Q8N136 L317F Polymorphism 0.205 0.387 0.74 -26 0.181 Q8N136 T121S Polymorphism 0.118 0.445 0.42 10 0.158 Q8N137 P578Q Polymorphism NA 0.113 0.63 -9 0.047 Q8N139 M698I Polymorphism 0.133 0.533 0.20 -30 0.097 Q8N139 N610Y Polymorphism 0.458 0.488 0.33 -29 0.213 Q8N139 V282I Polymorphism 0.042 0.343 0.19 -41 0.218 Q8N145 A524T Polymorphism 0.300 0.289 0.02 34 0.395 Q8N146 I201V Polymorphism 0.083 0.107 0.59 -14 0.129 Q8N146 P137S Polymorphism 0.402 0.045 1.00 -39 0.047 Q8N146 R295K Polymorphism 0.187 0.145 1.00 -42 0.108 Q8N148 S237F Polymorphism 0.963 0.938 0.00 41 0.932 Q8N148 V295A Polymorphism 0.446 0.770 0.01 35 0.843 Q8N149 H25N Polymorphism NA 0.328 0.38 -15 0.140 Q8N149 G361A Polymorphism 0.338 0.202 1.00 -54 0.158 Q8N149 R381C Polymorphism 0.342 0.626 0.01 28 0.335 Q8N157 R548H Polymorphism NA 0.281 0.00 53 0.264 Q8N157 R723Q Disease 0.401 0.556 0.01 52 0.589 Q8N157 S761L Polymorphism 0.152 0.619 0.00 50 0.656 Q8N157 T856S Polymorphism 0.272 0.199 0.12 -30 0.188 Q8N157 V443D Disease NA 0.430 0.00 49 0.641 Q8N157 Y933C Polymorphism NA 0.291 0.00 54 0.560 Q8N157 P1140S Polymorphism NA 0.144 0.63 15 0.025 Q8N157 Q1018P Polymorphism NA 0.249 0.00 8 0.192 Q8N157 S1123F Polymorphism NA 0.129 0.00 -67 0.192 Q8N159 A279P Disease 0.549 0.512 0.01 24 0.746 Q8N159 A518T Disease 0.397 0.243 0.07 37 0.349 Q8N159 C200R Disease 0.147 0.472 0.04 45 0.373 Q8N159 L430P Disease 0.765 0.913 0.00 33 0.874 Q8N159 S410P Disease 0.502 0.739 0.08 44 0.796 Q8N159 W484R Disease 0.516 0.989 0.00 66 0.924 Q8N162 H120Y Polymorphism 0.376 0.210 1.00 -32 0.080 Q8N162 Y169C Polymorphism 0.324 0.273 1.00 -2 0.143 Q8N196 A158T Disease 0.397 0.192 0.52 0 0.195 Q8N196 A296T Disease 0.453 0.060 0.44 30 0.072 Q8N196 G365R Disease 0.505 0.116 0.54 42 0.091 Q8N196 L556V Polymorphism NA 0.022 0.99 -30 0.019 Q8N196 T552M Disease NA 0.271 0.15 34 0.170 Q8N196 V693M Polymorphism NA 0.084 0.07 31 0.064 Q8N1A6 R40M Polymorphism NA 0.051 0.07 24 0.064 Q8N1A6 H166R Polymorphism NA 0.630 0.00 52 0.715 Q8N1A6 S104L Polymorphism NA 0.090 0.00 -9 0.164 Q8N1B3 C183S Polymorphism 0.456 0.771 0.60 39 0.623 Q8N1D0 R133G Polymorphism NA 0.131 NA 27 0.020 Q8N1D5 F191L Polymorphism NA 0.099 NA 0 0.058 Q8N1E6 L220V Polymorphism 0.330 0.346 0.11 60 0.409 Q8N1F1 S78T Polymorphism NA 0.105 NA 38 0.051 Q8N1F7 S509R Polymorphism 0.321 0.541 0.09 21 0.662 Q8N1F8 R393H Polymorphism NA 0.176 0.00 -34 0.237 Q8N1F8 R410G Polymorphism NA 0.243 0.00 36 0.412 Q8N1G0 G259E Polymorphism NA 0.103 0.28 -6 0.053 Q8N1G0 R344T Polymorphism NA 0.394 0.00 56 0.710 Q8N1G1 I804V Polymorphism NA 0.059 0.01 -29 0.107 Q8N1G1 S886G Polymorphism NA 0.084 0.01 18 0.150 Q8N1H7 S309L Polymorphism NA 0.170 NA 14 0.069 Q8N1I0 E606Q Polymorphism 0.210 0.143 0.60 -43 0.216 Q8N1I0 N535D Polymorphism 0.203 0.277 0.16 -10 0.153 Q8N1I0 R853H Polymorphism 0.378 0.277 0.15 -26 0.356 Q8N1I0 F1580L Polymorphism 0.807 0.880 0.05 31 0.726 Q8N1I0 P1733A Polymorphism 0.085 0.180 0.45 14 0.133 Q8N1I0 P1917L Polymorphism 0.092 0.240 0.00 38 0.295 Q8N1I0 Q1822K Polymorphism 0.274 0.108 0.95 8 0.084 Q8N1I0 R1570K Polymorphism 0.165 0.325 0.80 -15 0.214 Q8N1I0 S1926L Polymorphism 0.283 0.111 0.48 10 0.092 Q8N1I0 V1914I Polymorphism 0.125 0.159 0.39 14 0.119 Q8N1K5 I630V Polymorphism NA 0.023 NA -24 0.016 Q8N1K5 V284G Polymorphism NA 0.383 0.21 20 0.484 Q8N1N0 K564R Polymorphism NA 0.050 0.27 48 0.044 Q8N1N0 R101Q Polymorphism NA 0.028 0.66 -40 0.026 Q8N1N4 A238T Polymorphism 0.309 0.353 0.42 -33 0.302 Q8N1N4 G224A Polymorphism 0.578 0.287 1.00 -63 0.322 Q8N1N5 V120M Polymorphism NA 0.027 NA -6 0.034 Q8N1P7 S249N Polymorphism 0.430 0.178 0.28 -13 0.198 Q8N1Q1 N68S Polymorphism 0.158 0.368 0.02 -4 0.163 Q8N1Q8 Y55S Polymorphism NA 0.412 0.13 31 0.519 Q8N1T3 S37R Polymorphism 0.204 0.534 0.44 -23 0.191 Q8N1T3 L1011P Polymorphism NA 0.330 0.32 -12 0.054 Q8N1V2 E336K Polymorphism 0.657 0.258 0.50 21 0.428 Q8N1W1 R98M Polymorphism 0.953 0.250 0.00 31 0.620 Q8N1W1 H780N Polymorphism 0.802 0.144 0.51 14 0.252 Q8N1W1 R585K Polymorphism 0.593 0.339 0.02 6 0.548 Q8N1W1 S544L Polymorphism 0.797 0.123 0.02 5 0.101 Q8N1W1 W225R Polymorphism 0.554 0.131 0.15 20 0.066 Q8N205 Q278H Polymorphism 0.085 0.047 0.59 -17 0.021 Q8N228 R126Q Polymorphism NA 0.145 0.44 51 0.261 Q8N283 N53K Polymorphism 0.116 0.315 0.07 24 0.242 Q8N283 N978D Polymorphism NA 0.218 0.78 30 0.387 Q8N2A8 L42P Polymorphism 0.394 0.531 0.00 -11 0.490 Q8N2A8 R108H Polymorphism 0.201 0.141 0.04 0 0.221 Q8N2C7 R131W Polymorphism NA 0.150 0.02 31 0.156 Q8N2C9 V98F Polymorphism NA 0.239 NA 42 0.084 Q8N2E2 Q1256K Polymorphism NA 0.324 0.53 13 0.214 Q8N2F6 P190S Polymorphism 0.104 0.245 1.00 -7 0.202 Q8N2G6 E43V Polymorphism NA 0.149 NA 13 0.098 Q8N2H3 M461T Polymorphism 0.311 0.154 0.50 -4 0.101 Q8N2H3 P428S Polymorphism 0.292 0.243 0.13 30 0.359 Q8N2K0 A349T Polymorphism 0.181 0.215 0.15 -28 0.208 Q8N2S1 R635G Polymorphism 0.559 0.471 0.34 17 0.383 Q8N2S1 T820A Polymorphism NA 0.355 0.81 -11 0.262 Q8N2X6 P50S Polymorphism NA 0.155 NA 37 0.065 Q8N2Y8 P654L Polymorphism 0.252 0.070 0.00 26 0.167 Q8N302 E133K Disease 0.142 0.155 NA 27 0.126 Q8N302 L471P Polymorphism 0.711 0.786 NA 40 0.841 Q8N302 T180A Polymorphism 0.119 0.045 0.00 -11 0.080 Q8N307 C3S Polymorphism NA 0.167 NA -17 0.022 Q8N307 V18G Polymorphism NA 0.468 NA 12 0.352 Q8N307 P590L Polymorphism NA 0.057 0.44 -1 0.037 Q8N307 R666W Polymorphism NA 0.644 NA 44 0.720 Q8N307 S671C Polymorphism NA 0.389 NA 26 0.280 Q8N323 G353R Polymorphism 0.919 0.963 0.00 75 0.957 Q8N328 Q446E Polymorphism NA 0.077 0.59 -6 0.112 Q8N335 E83K Disease 0.492 0.682 0.64 2 0.446 Q8N335 A280V Disease 0.281 0.249 0.60 -31 0.268 Q8N335 I124V Disease 0.264 0.139 0.87 -21 0.115 Q8N335 L178F Polymorphism 0.724 0.523 0.13 -32 0.554 Q8N335 R273C Disease 0.887 0.913 0.18 38 0.907 Q8N339 T20K Polymorphism 0.253 0.135 1.00 10 0.028 Q8N344 D68N Polymorphism NA 0.054 0.24 -2 0.068 Q8N344 D104N Polymorphism NA 0.057 0.18 8 0.050 Q8N344 P464S Polymorphism NA 0.121 0.07 1 0.112 Q8N344 S485G Polymorphism NA 0.125 0.00 -11 0.092 Q8N349 L156F Polymorphism 0.174 0.815 0.45 -15 0.315 Q8N386 P294S Polymorphism 0.064 0.218 NA 29 0.222 Q8N387 S19W Polymorphism NA 0.121 NA -3 0.100 Q8N394 D741Y Polymorphism 0.734 0.355 1.00 36 0.621 Q8N394 Y443S Polymorphism NA 0.244 0.40 10 0.316 Q8N398 P211S Polymorphism NA 0.082 0.15 29 0.088 Q8N3C0 E344K Polymorphism NA 0.313 0.00 0 0.300 Q8N3C0 L146F Polymorphism NA 0.146 0.22 1 0.138 Q8N3C0 C1800W Polymorphism 0.970 0.847 0.03 69 0.935 Q8N3C0 R1497T Polymorphism 0.150 0.575 0.12 9 0.174 Q8N3C0 V1425A Polymorphism 0.487 0.458 0.02 54 0.691 Q8N3D4 V538G Polymorphism NA 0.247 NA 27 0.146 Q8N3E9 P652L Polymorphism 0.578 0.836 0.01 17 0.776 Q8N3F8 H685R Polymorphism NA 0.585 0.45 26 0.437 Q8N3F8 P583L Polymorphism NA 0.137 0.18 37 0.152 Q8N3G9 E407V Polymorphism NA 0.203 NA 32 0.166 Q8N3J2 E230D Polymorphism 0.285 0.158 0.10 5 0.146 Q8N3J3 T126P Polymorphism NA 0.068 0.06 -24 0.008 Q8N3K9 Y64C Polymorphism NA 0.072 NA -22 0.032 Q8N3K9 D190G Polymorphism NA 0.380 NA 32 0.348 Q8N3K9 A1333V Polymorphism NA 0.044 NA -34 0.028 Q8N3K9 A1875V Polymorphism NA 0.078 NA 31 0.053 Q8N3K9 G2935R Polymorphism 0.376 0.362 NA 32 0.309 Q8N3K9 I1309V Polymorphism NA 0.061 NA 27 0.045 Q8N3K9 I1713N Polymorphism NA 0.149 NA 22 0.085 Q8N3K9 K2383E Polymorphism NA 0.101 NA 16 0.056 Q8N3K9 K2906N Polymorphism NA 0.053 NA 15 0.064 Q8N3K9 L1669S Polymorphism NA 0.221 NA 23 0.125 Q8N3K9 R3927Q Polymorphism 0.244 0.692 0.01 46 0.479 Q8N3K9 S1599A Polymorphism NA 0.058 NA 22 0.050 Q8N3K9 V1006A Polymorphism NA 0.081 NA -5 0.035 Q8N3K9 V2262L Polymorphism NA 0.022 NA -21 0.018 Q8N3L3 A602P Polymorphism NA 0.058 0.39 4 0.032 Q8N3L3 I527T Polymorphism NA 0.091 1.00 -12 0.063 Q8N3L3 V348M Polymorphism 0.105 0.077 0.14 -39 0.110 Q8N3P4 I1364T Polymorphism NA 0.060 0.09 -13 0.036 Q8N3P4 R1372H Polymorphism NA 0.112 0.00 38 0.143 Q8N3T1 V68G Polymorphism 0.299 0.245 0.00 34 0.226 Q8N3T1 P324A Polymorphism 0.537 0.280 0.77 -18 0.496 Q8N3U4 N699K Polymorphism 0.335 0.561 0.02 -5 0.509 Q8N3Y7 R62W Polymorphism 0.921 0.845 0.00 15 0.847 Q8N3Z3 Q242H Polymorphism NA 0.483 0.03 -23 0.429 Q8N402 T131P Polymorphism 0.392 0.218 NA -5 0.189 Q8N412 K279R Polymorphism 0.283 0.068 0.28 25 0.074 Q8N412 V420A Polymorphism NA 0.143 0.06 17 0.147 Q8N412 Y125H Polymorphism 0.579 0.724 0.00 66 0.883 Q8N423 H20R Polymorphism NA 0.380 0.44 -57 0.238 Q8N423 F326S Polymorphism 0.180 0.202 1.00 -17 0.130 Q8N423 R349G Polymorphism 0.092 0.226 0.39 18 0.149 Q8N423 T324R Polymorphism 0.139 0.379 0.52 -13 0.155 Q8N423 V235M Polymorphism 0.353 0.180 0.01 -6 0.258 Q8N427 C208R Polymorphism NA 0.359 0.01 22 0.497 Q8N434 F385C Polymorphism 0.421 0.814 0.20 4 0.530 Q8N441 P362Q Polymorphism 0.151 0.401 0.62 10 0.251 Q8N442 T329I Polymorphism 0.376 0.354 0.12 19 0.377 Q8N448 S198P Polymorphism 0.059 0.164 0.32 -30 0.056 Q8N456 G7V Polymorphism 0.067 0.355 0.24 32 0.242 Q8N456 R31H Polymorphism 0.235 0.220 0.21 -16 0.214 Q8N465 R15G Polymorphism NA 0.129 0.00 26 0.177 Q8N465 D375Y Disease 0.856 0.646 0.00 44 0.836 Q8N465 I147S Disease 0.771 0.334 0.03 39 0.631 Q8N465 N439D Disease 0.973 0.920 0.00 63 0.940 Q8N465 V444A Disease 0.636 0.423 0.11 13 0.579 Q8N475 D711Y Polymorphism 0.848 0.507 0.03 38 0.748 Q8N490 A7V Disease NA 0.208 0.00 21 0.134 Q8N490 A9V Disease NA 0.256 0.00 29 0.169 Q8N4A0 I270T Polymorphism 0.604 0.281 0.07 -10 0.367 Q8N4B4 L231F Polymorphism NA 0.134 0.00 12 0.044 Q8N4B4 S221T Polymorphism NA 0.040 0.63 26 0.048 Q8N4C6 Q1934E Polymorphism NA 0.094 0.51 -23 0.069 Q8N4C6 S1837T Polymorphism NA 0.053 0.46 -30 0.042 Q8N4C8 V863I Polymorphism NA 0.156 0.14 3 0.120 Q8N4F0 K31M Polymorphism 0.581 0.101 0.28 40 0.109 Q8N4F7 M159V Polymorphism 0.226 0.730 0.00 -10 0.457 Q8N4H0 R243G Polymorphism NA 0.172 0.11 35 0.190 Q8N4M1 V438I Polymorphism 0.065 0.274 0.50 17 0.221 Q8N4N8 A112V Polymorphism NA 0.147 0.68 0 0.130 Q8N4N8 G128R Polymorphism NA 0.163 0.03 35 0.169 Q8N4P2 I446V Polymorphism 0.139 0.414 0.47 -7 0.230 Q8N4P6 A533T Polymorphism NA 0.028 NA 12 0.032 Q8N4P6 R483H Polymorphism NA 0.159 0.00 55 0.193 Q8N4Q0 C323F Polymorphism 0.343 0.585 0.39 -67 0.301 Q8N4S0 K128R Polymorphism 0.157 0.132 0.50 -11 0.079 Q8N4S0 Q327R Polymorphism 0.097 0.152 0.44 18 0.081 Q8N4U5 A41T Polymorphism NA 0.097 0.77 -43 0.079 Q8N4U5 A82S Polymorphism 0.326 0.222 0.30 21 0.303 Q8N4U5 D261N Polymorphism 0.214 0.094 1.00 -27 0.112 Q8N4W9 K134N Polymorphism NA 0.112 0.51 -11 0.143 Q8N4X5 E726K Polymorphism 0.081 0.079 0.50 2 0.078 Q8N511 L166V Polymorphism NA 0.220 NA -38 0.198 Q8N511 V158I Polymorphism NA 0.162 NA -34 0.092 Q8N543 P173S Polymorphism 0.240 0.722 0.50 3 0.375 Q8N554 E605D Polymorphism NA 0.137 0.01 11 0.189 Q8N554 R351W Polymorphism NA 0.206 0.04 57 0.419 Q8N556 S403C Polymorphism 0.203 0.603 0.01 14 0.609 Q8N568 G119C Polymorphism NA 0.924 0.00 39 0.808 Q8N568 I583V Polymorphism 0.168 0.127 0.82 -2 0.143 Q8N5A5 S61R Polymorphism NA 0.065 NA -13 0.037 Q8N5C6 T361M Polymorphism 0.619 0.532 0.10 23 0.746 Q8N5C7 E13K Polymorphism NA 0.114 0.81 -16 0.046 Q8N5C7 S25P Polymorphism NA 0.102 0.25 23 0.082 Q8N5C8 W394R Polymorphism 0.854 0.091 0.46 22 0.046 Q8N5D6 L20F Polymorphism 0.201 0.216 0.00 -9 0.271 Q8N5D6 S21G Polymorphism 0.221 0.165 0.51 -39 0.145 Q8N5D6 D200N Polymorphism 0.456 0.915 0.12 32 0.662 Q8N5D6 Q238P Polymorphism 0.451 0.563 0.25 -3 0.511 Q8N5D6 T248I Polymorphism 0.359 0.352 0.02 29 0.513 Q8N5F7 P115H Polymorphism 0.262 0.138 0.08 -22 0.127 Q8N5G0 A109T Polymorphism NA 0.134 NA -17 0.102 Q8N5I4 E297K Polymorphism 0.207 0.547 0.54 18 0.321 Q8N5I4 V247L Polymorphism 0.712 0.104 1.00 -49 0.053 Q8N5I9 G5S Polymorphism NA 0.220 NA 43 0.090 Q8N5S1 G144S Polymorphism 0.916 0.886 0.06 64 0.872 Q8N5S3 R275T Polymorphism NA 0.333 NA 57 0.318 Q8N5S9 E375G Polymorphism 0.268 0.278 0.44 27 0.315 Q8N5U0 P242S Polymorphism NA 0.069 NA -4 0.030 Q8N5U1 S20G Polymorphism NA 0.232 0.12 11 0.360 Q8N5U6 L332F Polymorphism NA 0.125 0.03 9 0.168 Q8N5V2 M111T Polymorphism NA 0.078 0.03 26 0.039 Q8N5W8 P2L Polymorphism NA 0.095 NA -30 0.022 Q8N5Y8 S280P Polymorphism 0.228 0.201 0.00 -8 0.247 Q8N5Z5 R51G Polymorphism 0.397 0.741 0.04 23 0.751 Q8N612 R619L Polymorphism 0.243 0.178 0.36 -2 0.062 Q8N612 T491M Polymorphism 0.274 0.171 0.10 7 0.280 Q8N614 Y48C Polymorphism NA 0.629 NA 54 0.654 Q8N614 M212T Polymorphism NA 0.481 NA 39 0.276 Q8N614 S105P Polymorphism NA 0.381 NA 52 0.214 Q8N628 P68S Polymorphism 0.853 0.120 1.00 -73 0.098 Q8N635 K75T Polymorphism NA 0.047 NA -9 0.082 Q8N635 I261T Polymorphism NA 0.098 NA -37 0.040 Q8N655 N49S Polymorphism 0.145 0.063 NA 21 0.037 Q8N655 A716P Polymorphism 0.493 0.043 0.01 -37 0.005 Q8N655 E396G Polymorphism 0.392 0.060 NA 11 0.045 Q8N655 I535L Polymorphism 0.148 0.065 NA 6 0.043 Q8N655 N579S Polymorphism 0.297 0.015 0.00 -27 0.044 Q8N655 P401A Polymorphism 0.381 0.035 NA -24 0.031 Q8N661 A176T Polymorphism NA 0.519 0.00 36 0.595 Q8N693 T314P Polymorphism 0.350 0.162 0.07 -48 0.015 Q8N695 F251V Polymorphism 0.379 0.894 0.19 4 0.529 Q8N695 V193I Polymorphism 0.456 0.427 0.19 -46 0.295 Q8N699 G119S Polymorphism NA 0.246 0.81 2 0.104 Q8N6C5 N381H Polymorphism 0.386 0.348 0.19 67 0.319 Q8N6C7 H91Q Polymorphism NA 0.106 NA 23 0.051 Q8N6C7 R73S Polymorphism NA 0.087 NA 31 0.050 Q8N6C8 L107R Polymorphism 0.095 0.452 0.09 15 0.140 Q8N6C8 W307C Polymorphism 0.485 0.280 0.00 54 0.547 Q8N6C8 Y301H Polymorphism 0.163 0.196 0.68 -22 0.185 Q8N6D5 G112E Polymorphism 0.083 0.225 0.21 60 0.393 Q8N6F1 G20D Disease 0.633 0.964 0.01 31 0.869 Q8N6F1 L13F Polymorphism 0.441 0.932 0.01 -7 0.652 Q8N6F1 L90P Disease 0.757 0.943 0.00 49 0.920 Q8N6F1 Q57E Disease 0.352 0.804 0.01 43 0.682 Q8N6G6 S242N Polymorphism 0.048 0.534 0.52 31 0.078 Q8N6H7 R339H Polymorphism 0.658 0.273 0.11 28 0.539 Q8N6H7 R406W Polymorphism 0.841 0.447 0.08 40 0.642 Q8N6H7 S411N Polymorphism 0.395 0.118 0.78 -17 0.112 Q8N6I1 A6T Polymorphism NA 0.070 0.00 17 0.136 Q8N6I1 E60A Polymorphism NA 0.097 0.60 9 0.033 Q8N6L0 L116P Polymorphism NA 0.452 0.00 31 0.249 Q8N6L0 R129Q Polymorphism NA 0.033 0.62 -8 0.045 Q8N6M0 R283Q Polymorphism 0.425 0.090 0.43 -13 0.115 Q8N6M6 R386C Polymorphism NA 0.297 0.03 57 0.613 Q8N6M6 V179I Polymorphism NA 0.064 0.60 19 0.101 Q8N6M8 Q76K Polymorphism 0.174 0.670 0.00 45 0.705 Q8N6M9 H53L Polymorphism 0.391 0.277 0.70 -3 0.349 Q8N6P7 A209S Polymorphism 0.090 0.080 0.74 -14 0.025 Q8N6P7 L222P Polymorphism 0.743 0.827 0.10 14 0.690 Q8N6P7 M407V Polymorphism 0.060 0.030 0.20 -25 0.030 Q8N6P7 S130P Polymorphism 0.117 0.162 0.87 -16 0.050 Q8N6P7 V205I Polymorphism 0.195 0.110 0.84 20 0.128 Q8N6Q3 A348T Polymorphism NA 0.097 0.45 -10 0.080 Q8N6Q3 F379S Polymorphism NA 0.160 0.28 -2 0.044 Q8N6Q3 L119F Polymorphism NA 0.327 0.40 42 0.251 Q8N6Q3 L251I Polymorphism NA 0.033 1.00 -55 0.023 Q8N6Q3 R323Q Polymorphism NA 0.106 0.58 35 0.199 Q8N6R0 M359I Polymorphism 0.304 0.243 0.09 31 0.331 Q8N6S4 T413S Polymorphism 0.197 0.182 0.76 0 0.136 Q8N6T7 S46N Polymorphism NA 0.671 0.37 -58 0.384 Q8N6Y0 V525M Polymorphism 0.267 0.090 0.18 6 0.044 Q8N6Y2 T95I Polymorphism 0.096 0.270 0.19 22 0.150 Q8N6Y2 G187A Polymorphism NA 0.613 0.73 39 0.519 Q8N6Y2 K119E Polymorphism 0.193 0.136 1.00 39 0.113 Q8N715 V195A Polymorphism NA 0.090 NA 34 0.044 Q8N720 E52D Polymorphism 0.080 0.527 0.29 -9 0.155 Q8N726 P154L Polymorphism 0.601 0.176 0.35 16 0.241 Q8N729 D149A Polymorphism NA 0.161 NA 27 0.068 Q8N743 A348P Polymorphism 0.113 0.516 0.34 -17 0.098 Q8N752 S5G Polymorphism NA 0.644 0.23 23 0.488 Q8N752 D42E Polymorphism 0.554 0.109 0.40 -45 0.111 Q8N752 A257T Polymorphism 0.423 0.625 0.40 -20 0.454 Q8N752 E177K Polymorphism 0.540 0.592 0.13 42 0.572 Q8N752 P220L Polymorphism 0.955 0.897 0.11 55 0.931 Q8N752 R170S Polymorphism 0.302 0.076 0.08 15 0.197 Q8N766 S345T Polymorphism 0.173 0.030 0.64 -31 0.030 Q8N766 S347N Polymorphism 0.272 0.024 0.33 -5 0.060 Q8N7B1 A2T Polymorphism NA 0.370 0.00 -46 0.270 Q8N7B1 V20L Polymorphism NA 0.116 0.14 -16 0.077 Q8N7B9 M364I Polymorphism NA 0.022 1.00 -19 0.009 Q8N7B9 S370A Polymorphism NA 0.169 0.00 43 0.058 Q8N7E2 D166E Polymorphism 0.117 0.051 1.00 5 0.051 Q8N7K9 E201G Polymorphism NA 0.097 0.26 29 0.070 Q8N7K9 I442L Polymorphism NA 0.035 0.48 -29 0.016 Q8N7K9 S214P Polymorphism NA 0.024 0.15 -48 0.018 Q8N7L0 R134C Polymorphism NA 0.057 NA 52 0.050 Q8N7M0 L143I Polymorphism 0.067 0.133 0.40 25 0.165 Q8N7M2 R629H Polymorphism 0.319 0.542 0.00 39 0.418 Q8N7Q3 E96K Polymorphism 0.333 0.183 0.84 -13 0.121 Q8N7Q3 S292W Polymorphism 0.362 0.273 0.21 -6 0.197 Q8N7S2 V4G Polymorphism NA 0.146 0.02 -17 0.149 Q8N7S2 H51R Polymorphism NA 0.290 NA 20 0.092 Q8N7W2 N341S Polymorphism NA 0.322 0.17 11 0.257 Q8N7X0 I310T Polymorphism 0.086 0.097 0.04 21 0.103 Q8N7X2 S126G Polymorphism NA 0.118 NA 40 0.115 Q8N7Z5 D702N Polymorphism NA 0.068 0.00 -9 0.075 Q8N801 L17M Polymorphism NA 0.106 NA 33 0.099 Q8N801 Q31R Polymorphism NA 0.038 NA -15 0.018 Q8N807 A26T Polymorphism NA 0.085 1.00 -31 0.073 Q8N807 L475R Polymorphism 0.663 0.596 0.62 -4 0.422 Q8N807 R527K Polymorphism NA 0.049 1.00 -44 0.011 Q8N807 V447I Polymorphism 0.588 0.263 0.60 -31 0.088 Q8N815 T145P Polymorphism 0.486 0.784 NA 9 0.732 Q8N816 I4M Polymorphism NA 0.269 NA -29 0.099 Q8N816 L95R Polymorphism NA 0.734 NA 34 0.511 Q8N816 Y79H Polymorphism NA 0.439 NA 21 0.236 Q8N823 E340G Polymorphism 0.860 0.386 0.07 38 0.724 Q8N831 A60V Polymorphism NA 0.107 0.68 -16 0.072 Q8N831 G109S Polymorphism NA 0.048 0.29 5 0.080 Q8N831 P116L Polymorphism NA 0.110 0.25 -3 0.187 Q8N865 E13K Polymorphism NA 0.648 NA 58 0.716 Q8N865 P238Q Polymorphism NA 0.070 NA 10 0.045 Q8N878 R274C Polymorphism NA 0.366 0.02 50 0.520 Q8N883 V415I Polymorphism 0.088 0.150 0.83 3 0.096 Q8N884 T35N Polymorphism NA 0.126 NA 35 0.020 Q8N884 P261H Polymorphism 0.803 0.194 0.05 53 0.449 Q8N895 A739G Polymorphism NA 0.184 NA 39 0.180 Q8N8A6 R41Q Polymorphism NA 0.050 0.80 3 0.032 Q8N8A6 E134V Polymorphism NA 0.185 0.37 7 0.308 Q8N8A6 Q295R Polymorphism 0.197 0.433 0.06 1 0.356 Q8N8B7 S163L Polymorphism 0.366 0.146 0.34 5 0.128 Q8N8D7 V140I Polymorphism 0.131 0.109 0.23 4 0.127 Q8N8E3 K551E Polymorphism 0.227 0.319 0.60 -12 0.203 Q8N8F6 A54T Polymorphism 0.093 0.157 0.21 13 0.188 Q8N8G6 E77K Polymorphism NA 0.239 NA 29 0.046 Q8N8G6 T59M Polymorphism NA 0.212 NA 30 0.063 Q8N8J6 T129M Polymorphism NA 0.098 0.10 -24 0.208 Q8N8Q3 K114R Polymorphism NA 0.148 0.08 -13 0.203 Q8N8U9 R555W Polymorphism 0.770 0.270 0.22 45 0.599 Q8N8V2 G618R Polymorphism 0.084 0.367 0.00 53 0.563 Q8N8W4 S522P Polymorphism 0.387 0.033 0.07 -25 0.009 Q8N8W4 T490M Polymorphism 0.465 0.047 0.10 31 0.011 Q8N8Y2 E295K Polymorphism 0.331 0.463 0.03 1 0.372 Q8N8Y2 G272R Polymorphism 0.147 0.351 0.46 13 0.383 Q8N945 N99S Polymorphism 0.074 0.043 0.02 -5 0.100 Q8N960 L602V Polymorphism 0.335 0.443 0.00 32 0.601 Q8N999 P23L Polymorphism NA 0.121 0.00 -5 0.163 Q8N999 V238L Polymorphism NA 0.018 1.00 -34 0.010 Q8N9B5 A592V Polymorphism 0.067 0.025 0.30 -45 0.032 Q8N9B5 H720R Polymorphism 0.060 0.049 0.70 17 0.041 Q8N9B5 M364L Polymorphism 0.065 0.134 0.36 -39 0.042 Q8N9C0 A94P Polymorphism NA 0.113 1.00 8 0.122 Q8N9C0 L130R Polymorphism NA 0.606 0.04 65 0.829 Q8N9C0 L677F Polymorphism NA 0.234 0.13 40 0.399 Q8N9C0 R472Q Polymorphism NA 0.161 0.36 -11 0.281 Q8N9C0 V414I Polymorphism NA 0.340 0.56 3 0.320 Q8N9E0 E67K Polymorphism NA 0.084 0.37 1 0.089 Q8N9F8 D166A Polymorphism 0.098 0.209 0.79 21 0.149 Q8N9H6 L39P Polymorphism NA 0.257 NA 43 0.058 Q8N9H9 R256Q Polymorphism NA 0.020 NA -21 0.023 Q8N9K5 I188T Polymorphism 0.082 0.378 0.69 11 0.240 Q8N9K7 S111T Polymorphism NA 0.189 NA 25 0.034 Q8N9L9 R57C Polymorphism NA 0.322 0.18 33 0.503 Q8N9L9 A187D Polymorphism NA 0.942 0.00 57 0.918 Q8N9P6 L5P Polymorphism NA 0.193 NA 24 0.040 Q8N9R8 A37T Polymorphism 0.042 0.065 NA -27 0.035 Q8N9S9 D73H Polymorphism 0.177 0.280 0.01 6 0.289 Q8N9S9 Q309R Polymorphism 0.126 0.418 0.84 0 0.201 Q8N9T8 G144R Polymorphism NA 0.095 0.44 34 0.189 Q8N9T8 L451P Polymorphism 0.198 0.325 0.23 35 0.220 Q8N9T8 R342W Polymorphism 0.821 0.287 0.02 9 0.581 Q8N9T8 S315L Polymorphism 0.321 0.151 0.21 6 0.219 Q8N9V2 E132K Polymorphism 0.328 0.584 0.29 -18 0.457 Q8N9V3 H223D Polymorphism 0.125 0.308 0.63 16 0.171 Q8N9V3 K215T Polymorphism 0.333 0.672 0.03 40 0.656 Q8N9V6 L153I Polymorphism 0.105 0.252 0.33 -15 0.222 Q8N9V6 M243T Polymorphism 0.079 0.218 0.61 -1 0.132 Q8N9V7 K796E Polymorphism NA 0.202 0.03 51 0.285 Q8N9V7 Q483R Polymorphism NA 0.035 0.95 -15 0.026 Q8N9W4 E64G Polymorphism 0.782 0.081 1.00 -13 0.022 Q8N9W4 R43G Polymorphism 0.358 0.163 1.00 -3 0.093 Q8N9W4 R235P Polymorphism 0.526 0.404 0.08 51 0.529 Q8N9W4 W191R Polymorphism 0.613 0.430 0.38 16 0.499 Q8N9W5 D365N Polymorphism NA 0.137 0.16 -10 0.101 Q8N9W5 E292G Polymorphism NA 0.443 0.08 37 0.522 Q8N9W5 G331W Polymorphism NA 0.354 0.03 22 0.430 Q8N9Y4 A28T Polymorphism NA 0.067 0.00 26 0.121 Q8N9Z0 R216P Polymorphism 0.576 0.266 0.28 46 0.661 Q8N9Z0 R298I Polymorphism 0.571 0.258 0.36 15 0.572 Q8N9Z9 A290T Polymorphism NA 0.036 0.06 -29 0.012 Q8N9Z9 E267G Polymorphism NA 0.429 0.01 29 0.292 Q8NA03 N64D Polymorphism 0.281 0.043 0.58 -2 0.036 Q8NA03 G528A Polymorphism 0.325 0.149 NA 8 0.132 Q8NA47 L212S Polymorphism 0.224 0.149 0.71 -27 0.170 Q8NA54 D691N Polymorphism 0.257 0.089 0.00 -1 0.150 Q8NA54 R735P Polymorphism 0.092 0.256 0.09 8 0.053 Q8NA56 L94P Polymorphism 0.747 0.701 0.00 47 0.864 Q8NA56 A276T Polymorphism 0.094 0.280 0.00 12 0.276 Q8NA57 Q306R Polymorphism 0.285 0.035 1.00 43 0.045 Q8NA66 D64N Polymorphism NA 0.039 NA 21 0.030 Q8NA69 P497S Polymorphism NA 0.129 NA 57 0.082 Q8NA69 Y434N Polymorphism NA 0.422 NA 30 0.252 Q8NA72 A446T Polymorphism NA 0.212 0.22 -13 0.182 Q8NA82 G241E Polymorphism 0.064 0.157 NA 33 0.106 Q8NA92 K112R Polymorphism 0.273 0.075 0.47 -19 0.037 Q8NAA6 L3V Polymorphism NA 0.057 NA 4 0.046 Q8NAM6 E387K Polymorphism 0.552 0.329 0.28 -18 0.321 Q8NAT2 E722K Polymorphism 0.760 0.191 0.36 51 0.205 Q8NAT2 M104T Polymorphism NA 0.067 0.05 31 0.116 Q8NAX2 K189R Polymorphism NA 0.105 NA 4 0.068 Q8NAX2 Q100R Polymorphism NA 0.231 NA 44 0.191 Q8NB12 Q164P Polymorphism 0.500 0.264 0.27 -10 0.244 Q8NB16 D100E Polymorphism NA 0.055 0.20 -36 0.064 Q8NB16 M169L Polymorphism NA 0.072 0.65 -1 0.085 Q8NB16 R146Q Polymorphism NA 0.060 0.53 -3 0.065 Q8NB16 S132P Polymorphism NA 0.107 0.07 -3 0.115 Q8NB25 D599N Polymorphism NA 0.073 0.50 -32 0.105 Q8NB25 Q174H Polymorphism NA 0.145 0.11 35 0.138 Q8NB25 V177G Polymorphism NA 0.206 0.38 23 0.360 Q8NB49 Y522C Polymorphism NA 0.689 0.18 0 0.484 Q8NB66 S942L Polymorphism 0.185 0.093 0.00 9 0.119 Q8NB90 S673Y Polymorphism 0.726 0.766 0.00 60 0.875 Q8NBB2 V62A Polymorphism NA 0.086 NA -17 0.044 Q8NBF1 A187G Polymorphism NA 0.184 0.01 14 0.289 Q8NBF1 F157L Polymorphism 0.232 0.172 1.00 19 0.137 Q8NBF6 C257S Polymorphism NA 0.098 1.00 -6 0.063 Q8NBI3 L37F Polymorphism NA 0.056 0.21 24 0.047 Q8NBJ4 H217R Polymorphism 0.162 0.030 0.50 20 0.018 Q8NBJ9 T631M Polymorphism NA 0.133 0.05 31 0.070 Q8NBJ9 V636I Polymorphism NA 0.080 1.00 -37 0.053 Q8NBK3 L20F Disease 0.252 0.162 0.00 -62 0.111 Q8NBK3 A177P Disease 0.703 0.759 0.09 16 0.682 Q8NBK3 A279V Disease 0.378 0.791 0.07 28 0.654 Q8NBK3 A348P Disease 0.623 0.755 0.25 44 0.839 Q8NBK3 C218Y Disease 0.742 0.913 0.01 43 0.876 Q8NBK3 C336R Disease 0.822 0.833 0.01 70 0.928 Q8NBK3 N259I Disease 0.884 0.814 0.00 55 0.928 Q8NBK3 P266L Disease 0.887 0.835 0.00 46 0.878 Q8NBK3 R224W Disease 0.954 0.909 0.00 50 0.925 Q8NBK3 R345C Disease 0.767 0.883 0.00 66 0.921 Q8NBK3 R349Q Disease 0.407 0.849 0.00 73 0.912 Q8NBK3 R349W Disease 0.865 0.891 0.00 56 0.929 Q8NBK3 S155P Disease 0.823 0.748 0.06 57 0.841 Q8NBK3 W179S Disease 0.907 0.813 0.00 62 0.925 Q8NBL1 P229T Polymorphism 0.294 0.738 0.20 59 0.559 Q8NBM8 E390D Polymorphism NA 0.244 0.45 -18 0.251 Q8NBP7 A53V Polymorphism 0.064 0.104 0.22 -55 0.071 Q8NBP7 E57K Polymorphism 0.072 0.071 0.29 -45 0.055 Q8NBP7 R46L Polymorphism 0.194 0.103 0.04 -47 0.047 Q8NBP7 R93C Polymorphism 0.720 0.486 0.02 9 0.701 Q8NBP7 A239D Polymorphism 0.583 0.898 0.20 53 0.871 Q8NBP7 A522T Polymorphism NA 0.359 0.00 37 0.591 Q8NBP7 D129G Disease 0.503 0.249 0.02 -48 0.499 Q8NBP7 D374H Disease 0.675 0.451 0.52 46 0.673 Q8NBP7 D374Y Disease 0.769 0.446 1.00 47 0.624 Q8NBP7 F216L Disease 0.305 0.288 0.37 43 0.395 Q8NBP7 F515L Polymorphism NA 0.155 0.00 25 0.173 Q8NBP7 G106R Polymorphism 0.710 0.862 0.04 -42 0.663 Q8NBP7 G452D Polymorphism 0.099 0.321 0.09 32 0.218 Q8NBP7 H391N Polymorphism 0.560 0.916 0.07 51 0.898 Q8NBP7 N425S Polymorphism 0.395 0.264 0.10 -15 0.250 Q8NBP7 P616L Polymorphism NA 0.044 0.00 12 0.048 Q8NBP7 Q554E Polymorphism NA 0.077 0.01 35 0.065 Q8NBP7 Q619P Polymorphism NA 0.089 0.02 5 0.101 Q8NBP7 R215H Disease 0.649 0.173 0.17 43 0.486 Q8NBP7 R218S Disease 0.524 0.113 0.13 17 0.233 Q8NBP7 R357H Disease 0.405 0.555 0.03 34 0.759 Q8NBP7 R496W Disease 0.794 0.094 0.00 49 0.297 Q8NBP7 S127R Disease 0.540 0.634 0.05 0 0.611 Q8NBP7 S668R Polymorphism NA 0.067 0.00 16 0.175 Q8NBP7 V114A Polymorphism 0.363 0.217 0.19 -58 0.274 Q8NBR9 P22T Polymorphism NA 0.168 NA 10 0.056 Q8NBS3 N72T Polymorphism NA 0.254 NA 18 0.210 Q8NBS3 A327V Polymorphism 0.269 0.334 0.08 -1 0.343 Q8NBS3 G464D Disease 0.717 0.920 0.04 60 0.912 Q8NBS3 L843P Disease 0.775 0.961 0.00 47 0.887 Q8NBS3 M483T Polymorphism 0.556 0.715 0.01 36 0.829 Q8NBS3 M848I Polymorphism 0.097 0.587 0.60 -1 0.026 Q8NBS3 M856V Disease 0.293 0.824 0.37 29 0.503 Q8NBS3 N150S Polymorphism NA 0.119 0.43 -4 0.081 Q8NBS3 Q408H Polymorphism 0.371 0.313 0.28 43 0.493 Q8NBS3 R488K Disease 0.347 0.859 0.10 40 0.738 Q8NBS3 R755Q Disease 0.985 0.923 0.01 66 0.956 Q8NBS3 R804H Disease 0.658 0.901 0.00 63 0.915 Q8NBS3 R869C Disease 0.835 0.803 0.00 50 0.925 Q8NBS3 R869H Disease 0.658 0.816 0.00 40 0.857 Q8NBS3 S213P Disease 0.096 0.292 0.03 39 0.343 Q8NBS3 S489L Disease 0.618 0.790 0.21 32 0.748 Q8NBS3 T833M Disease 0.690 0.889 0.00 56 0.903 Q8NBS3 V824M Disease 0.541 0.873 0.00 53 0.846 Q8NBT0 G79S Polymorphism 0.146 0.506 0.56 24 0.229 Q8NBT0 Q348H Polymorphism 0.184 0.104 0.19 5 0.111 Q8NBV4 T174M Polymorphism 0.129 0.127 0.14 1 0.053 Q8NBV8 F129I Polymorphism 0.384 0.489 0.03 -37 0.453 Q8NC01 G26A Polymorphism 0.279 0.054 0.19 -24 0.080 Q8NC06 P118L Polymorphism 0.644 0.621 0.00 24 0.712 Q8NC24 G196R Polymorphism NA 0.067 0.00 24 0.165 Q8NC24 L133I Polymorphism NA 0.073 1.00 -18 0.014 Q8NC42 S9G Polymorphism 0.116 0.065 0.33 -5 0.049 Q8NC42 D356E Polymorphism 0.172 0.075 1.00 -22 0.037 Q8NC60 A153S Polymorphism NA 0.076 0.70 16 0.091 Q8NC60 K450R Polymorphism 0.090 0.041 0.00 27 0.088 Q8NC67 S456T Polymorphism 0.178 0.203 1.00 -7 0.160 Q8NC74 E607K Polymorphism 0.177 0.134 0.42 40 0.072 Q8NC74 L637R Polymorphism 0.240 0.269 0.35 46 0.292 Q8NC96 D224N Polymorphism 0.183 0.060 0.18 -6 0.071 Q8NCB2 P472L Polymorphism NA 0.091 0.24 26 0.052 Q8NCD3 E723G Polymorphism NA 0.133 NA 23 0.134 Q8NCD3 S549C Polymorphism NA 0.280 NA 18 0.153 Q8NCE0 R41H Polymorphism NA 0.172 0.01 48 0.147 Q8NCE0 R126H Polymorphism NA 0.105 0.13 13 0.099 Q8NCE0 Y309C Disease 0.875 0.876 0.03 54 0.925 Q8NCG7 Q664R Polymorphism 0.060 0.145 0.22 4 0.112 Q8NCK3 A252T Polymorphism 0.297 0.321 0.37 -39 0.069 Q8NCL4 V423I Polymorphism 0.485 0.203 0.24 -27 0.242 Q8NCL8 C22G Polymorphism NA 0.098 NA 6 0.040 Q8NCL9 C30R Polymorphism NA 0.057 NA 31 0.027 Q8NCL9 Y80H Polymorphism NA 0.647 0.00 18 0.486 Q8NCL9 R261C Polymorphism NA 0.781 0.00 53 0.825 Q8NCM8 H341Y Polymorphism NA 0.296 0.77 4 0.245 Q8NCM8 Q304L Polymorphism NA 0.127 1.00 7 0.106 Q8NCM8 R456Q Polymorphism NA 0.249 0.61 2 0.254 Q8NCM8 T302P Polymorphism NA 0.590 0.29 34 0.739 Q8NCM8 A3680V Polymorphism 0.049 0.315 0.00 16 0.280 Q8NCM8 Q4139P Polymorphism 0.323 0.440 0.24 40 0.331 Q8NCP5 K185E Polymorphism NA 0.148 0.45 57 0.112 Q8NCQ7 D245A Polymorphism 0.236 0.092 0.34 13 0.061 Q8NCR9 F75I Polymorphism NA 0.622 0.00 26 0.485 Q8NCU4 E696D Polymorphism 0.324 0.120 NA 8 0.116 Q8NCU4 R374W Polymorphism 0.888 0.500 NA 35 0.744 Q8NCV1 G44E Polymorphism NA 0.175 NA 11 0.015 Q8NCV1 G235R Polymorphism NA 0.491 0.59 46 0.432 Q8NCW0 A408P Polymorphism NA 0.049 0.04 -29 0.010 Q8NCW5 V19L Polymorphism NA 0.059 0.75 -61 0.020 Q8NCW6 D197Y Polymorphism 0.326 0.583 1.00 8 0.385 Q8ND07 D230V Polymorphism NA 0.080 0.95 -37 0.019 Q8ND07 K496E Polymorphism NA 0.094 0.69 13 0.073 Q8ND23 L1022M Polymorphism NA 0.074 0.24 -30 0.019 Q8ND56 R238Q Polymorphism 0.401 0.067 0.60 49 0.099 Q8ND56 R448Q Polymorphism 0.416 0.343 0.00 36 0.274 Q8ND61 A298T Polymorphism 0.065 0.073 NA 10 0.042 Q8ND61 A689V Polymorphism 0.408 0.110 NA -9 0.050 Q8ND61 L422V Polymorphism 0.063 0.284 0.10 32 0.202 Q8ND61 S230Y Polymorphism 0.130 0.221 NA 62 0.324 Q8ND90 R215P Polymorphism 0.752 0.732 0.04 39 0.831 Q8NDH2 P30S Polymorphism NA 0.068 NA 11 0.038 Q8NDH2 G264S Polymorphism NA 0.117 NA 12 0.088 Q8NDH2 G382A Polymorphism NA 0.034 NA 2 0.049 Q8NDH2 L347P Polymorphism NA 0.208 NA -7 0.079 Q8NDH2 E1879A Polymorphism NA 0.106 NA 28 0.084 Q8NDH2 L1382P Polymorphism NA 0.119 NA 35 0.019 Q8NDH2 N1121S Polymorphism NA 0.080 NA 9 0.035 Q8NDH2 R1209Q Polymorphism NA 0.163 NA 42 0.040 Q8NDH2 R1446C Polymorphism NA 0.118 NA 41 0.017 Q8NDH3 L513V Polymorphism NA 0.051 0.05 -33 0.012 Q8NDI1 K755Q Polymorphism 0.118 0.146 0.05 25 0.134 Q8NDN9 A24V Polymorphism 0.187 0.129 0.58 -15 0.121 Q8NDP4 P6S Polymorphism NA 0.565 0.48 12 0.407 Q8NDQ6 D53V Polymorphism 0.656 0.529 0.04 23 0.739 Q8NDV3 F473V Polymorphism 0.239 0.226 0.12 -26 0.183 Q8NDV3 R758Q Polymorphism 0.283 0.353 0.55 -7 0.289 Q8NDV3 L1050M Polymorphism 0.233 0.185 0.09 -1 0.205 Q8NDV7 A592T Polymorphism NA 0.153 0.67 11 0.128 Q8NDV7 P788S Polymorphism NA 0.141 0.21 -19 0.102 Q8NDW8 E293K Polymorphism 0.099 0.046 1.00 -25 0.016 Q8NDW8 R290K Polymorphism 0.165 0.050 1.00 17 0.071 Q8NDW8 R622W Polymorphism 0.876 0.500 0.00 53 0.873 Q8NDW8 R719Q Polymorphism 0.185 0.415 0.13 2 0.224 Q8NDW8 V108L Polymorphism 0.109 0.226 0.17 -28 0.036 Q8NDW8 R1055L Polymorphism 0.208 0.904 0.16 48 0.736 Q8NDX1 G269A Polymorphism NA 0.195 NA 16 0.171 Q8NDX1 I658V Polymorphism 0.185 0.379 0.42 -2 0.235 Q8NDX2 T8I Polymorphism NA 0.134 0.04 21 0.162 Q8NDX2 A211V Disease 0.668 0.188 0.51 -4 0.368 Q8NDX9 S131Y Polymorphism NA 0.220 0.00 47 0.236 Q8NDY8 M141T Polymorphism NA 0.222 0.03 0 0.168 Q8NDZ0 S188F Polymorphism NA 0.230 NA 36 0.125 Q8NDZ2 S221F Polymorphism NA 0.167 0.04 21 0.234 Q8NDZ2 S636F Polymorphism 0.278 0.174 NA 51 0.164 Q8NE18 T622A Polymorphism NA 0.078 0.09 2 0.046 Q8NE22 K209E Polymorphism NA 0.101 NA 6 0.099 Q8NE35 R324W Polymorphism NA 0.558 0.00 40 0.724 Q8NE62 E40A Polymorphism NA 0.399 0.03 24 0.438 Q8NE62 L78R Polymorphism NA 0.500 0.02 10 0.505 Q8NE63 A106T Polymorphism NA 0.231 0.13 -16 0.296 Q8NE63 S406R Polymorphism NA 0.062 0.00 39 0.193 Q8NE63 T381M Polymorphism NA 0.053 0.00 36 0.133 Q8NE63 V171M Polymorphism 0.716 0.126 0.13 52 0.487 Q8NE71 N198D Polymorphism NA 0.110 0.90 0 0.036 Q8NE79 M127I Polymorphism 0.143 0.114 0.12 3 0.098 Q8NE79 R129W Polymorphism 0.605 0.166 0.01 27 0.339 Q8NEA4 L86F Polymorphism NA 0.284 NA 37 0.396 Q8NEA6 S269P Polymorphism 0.208 0.136 0.29 3 0.111 Q8NEB7 T336A Polymorphism NA 0.179 0.10 45 0.152 Q8NEC5 T730P Polymorphism NA 0.182 0.00 21 0.209 Q8NEE6 D692G Polymorphism 0.199 0.213 0.13 48 0.203 Q8NEE6 I535V Polymorphism 0.111 0.234 0.61 -21 0.158 Q8NEE6 Y565C Polymorphism 0.382 0.153 0.15 35 0.331 Q8NEE8 A872S Polymorphism NA 0.295 NA 33 0.214 Q8NEE8 E588G Polymorphism NA 0.078 NA 28 0.057 Q8NEF3 H32L Polymorphism 0.144 0.077 0.07 11 0.066 Q8NEF3 K341N Polymorphism 0.112 0.100 0.20 28 0.067 Q8NEG0 R30G Polymorphism 0.653 0.671 0.02 36 0.782 Q8NEG4 R245S Polymorphism 0.590 0.635 0.01 27 0.625 Q8NEG4 R436G Polymorphism 0.707 0.217 0.00 25 0.417 Q8NEH6 E426G Polymorphism 0.228 0.187 0.02 45 0.355 Q8NEJ9 K308I Polymorphism 0.130 0.064 0.00 33 0.114 Q8NEL0 R38Q Polymorphism NA 0.085 0.63 -8 0.029 Q8NEM0 T27R Disease NA 0.437 0.00 32 0.568 Q8NEM0 L602F Polymorphism 0.307 0.062 0.05 17 0.090 Q8NEM0 P288H Polymorphism 0.481 0.263 0.02 31 0.401 Q8NEM0 P828S Polymorphism NA 0.020 0.31 -9 0.012 Q8NEM0 S580G Polymorphism 0.441 0.133 0.24 3 0.124 Q8NEM0 T682N Polymorphism 0.316 0.241 0.14 35 0.244 Q8NEM0 V761A Polymorphism 0.121 0.078 0.05 5 0.084 Q8NEM7 T773M Polymorphism 0.132 0.035 NA 3 0.044 Q8NEM8 E122Q Polymorphism NA 0.080 0.13 -47 0.102 Q8NEM8 T360I Polymorphism 0.774 0.474 0.07 37 0.673 Q8NEN0 M166T Polymorphism 0.319 0.078 NA -21 0.041 Q8NEN0 N433D Polymorphism NA 0.065 NA -14 0.080 Q8NEN9 V806A Polymorphism 0.134 0.088 0.01 4 0.112 Q8NEP3 E432D Polymorphism 0.146 0.166 0.06 -5 0.044 Q8NEP3 F545C Polymorphism 0.035 0.272 0.00 37 0.206 Q8NEP3 L633S Polymorphism 0.191 0.260 0.38 -35 0.106 Q8NEP3 P712A Polymorphism 0.155 0.081 0.00 13 0.112 Q8NEP4 G461S Polymorphism NA 0.032 0.78 -34 0.024 Q8NEP7 S171R Polymorphism NA 0.109 NA 12 0.029 Q8NEP9 H194N Polymorphism 0.063 0.664 0.03 68 0.982 Q8NEP9 K515T Polymorphism 0.053 0.511 0.02 57 0.939 Q8NEQ6 L112F Polymorphism NA 0.083 NA -4 0.059 Q8NER1 P91S Polymorphism NA 0.073 0.26 16 0.048 Q8NER1 I585V Polymorphism 0.070 0.077 1.00 -25 0.060 Q8NER1 T469I Polymorphism 0.134 0.750 0.42 23 0.291 Q8NER5 G216R Polymorphism 0.693 0.911 0.01 65 0.926 Q8NER5 I195T Polymorphism 0.926 0.577 0.00 11 0.787 Q8NER5 I355V Polymorphism 0.303 0.079 0.65 1 0.140 Q8NER5 I482V Polymorphism 0.321 0.282 0.23 1 0.215 Q8NES3 F188L Disease 0.584 0.953 0.01 36 0.854 Q8NES3 V346M Polymorphism NA 0.248 0.35 -2 0.237 Q8NET1 H45L Polymorphism NA 0.146 0.09 -10 0.081 Q8NET1 I27V Polymorphism NA 0.100 0.00 0 0.061 Q8NET1 Q53R Polymorphism NA 0.029 0.42 23 0.028 Q8NET1 R36W Polymorphism NA 0.338 0.00 65 0.355 Q8NET4 P777S Polymorphism 0.419 0.028 0.45 -16 0.032 Q8NET6 R317Q Polymorphism 0.377 0.233 0.63 -7 0.250 Q8NEU8 A433V Polymorphism 0.158 0.055 0.03 15 0.092 Q8NEV4 A833S Polymorphism 0.897 0.876 0.02 38 0.846 Q8NEV4 D204N Polymorphism NA 0.333 0.01 28 0.404 Q8NEV4 I348V Polymorphism 0.124 0.063 0.50 -19 0.103 Q8NEV4 S956N Polymorphism 0.162 0.139 0.46 -58 0.125 Q8NEV4 A1032T Polymorphism 0.161 0.482 0.20 -27 0.305 Q8NEV4 K1488E Polymorphism 0.040 0.122 0.36 31 0.082 Q8NEV4 R1313S Polymorphism NA 0.339 0.68 -2 0.151 Q8NEV4 V1045M Polymorphism 0.500 0.332 0.22 4 0.311 Q8NEV8 D777N Polymorphism 0.338 0.181 NA 24 0.164 Q8NEV8 E137V Polymorphism NA 0.134 NA 47 0.144 Q8NEV8 N892Y Polymorphism 0.568 0.052 NA 19 0.079 Q8NEV8 R118L Polymorphism NA 0.176 NA 45 0.203 Q8NEV8 V525F Polymorphism 0.594 0.400 NA 65 0.601 Q8NEV8 V899A Polymorphism 0.292 0.127 NA 4 0.054 Q8NEV8 C1311R Polymorphism 0.602 0.054 NA 13 0.071 Q8NEV8 D1240N Polymorphism 0.493 0.286 NA 17 0.159 Q8NEV8 E1656K Polymorphism 0.469 0.044 NA 36 0.058 Q8NEV8 I1735F Polymorphism 0.391 0.137 NA 25 0.037 Q8NEV8 S1236A Polymorphism 0.313 0.077 NA 26 0.076 Q8NEV8 T1343A Polymorphism 0.337 0.117 NA 21 0.055 Q8NEV9 S59A Polymorphism 0.100 0.275 NA 23 0.128 Q8NEV9 L119P Polymorphism 0.163 0.388 NA 56 0.141 Q8NEW7 R81C Disease NA 0.741 NA 73 0.867 Q8NEW7 R84W Disease NA 0.858 NA 62 0.896 Q8NEW7 R92W Disease NA 0.434 NA 22 0.387 Q8NEX5 N27T Polymorphism NA 0.045 0.54 23 0.019 Q8NEY1 H1290D Polymorphism NA 0.304 0.10 35 0.498 Q8NEY1 S1273L Polymorphism 0.074 0.516 0.01 2 0.207 Q8NEY4 N143D Polymorphism NA 0.914 0.11 30 0.828 Q8NEZ3 G1084S Polymorphism 0.586 0.798 0.01 35 0.718 Q8NEZ4 I823T Polymorphism NA 0.521 0.39 23 0.701 Q8NEZ4 P2600A Polymorphism NA 0.143 0.08 13 0.139 Q8NEZ4 S1836N Polymorphism NA 0.093 0.08 9 0.098 Q8NF50 A597V Polymorphism 0.394 0.515 1.00 38 0.522 Q8NF50 E237K Polymorphism 0.142 0.283 0.79 3 0.213 Q8NF50 N413S Polymorphism 0.122 0.205 1.00 -19 0.170 Q8NF91 L885V Polymorphism 0.135 0.102 0.31 0 0.083 Q8NF91 A2795V Polymorphism NA 0.112 0.32 0 0.201 Q8NF91 E4060D Polymorphism NA 0.109 0.33 0 0.082 Q8NF91 G8323A Polymorphism 0.098 0.183 0.76 0 0.119 Q8NF91 K3874T Polymorphism NA 0.106 0.38 0 0.173 Q8NF91 K4121N Polymorphism NA 0.246 0.46 0 0.345 Q8NF91 K4121R Polymorphism NA 0.190 0.58 0 0.133 Q8NF91 M6566I Polymorphism NA 0.215 0.44 0 0.163 Q8NF91 N8161H Polymorphism 0.253 0.226 0.15 0 0.267 Q8NF91 S2030G Polymorphism NA 0.138 0.20 0 0.126 Q8NF91 S7506G Polymorphism NA 0.241 0.44 0 0.253 Q8NF91 T8687I Polymorphism 0.411 0.124 0.10 0 0.235 Q8NF91 V1035A Polymorphism 0.162 0.089 0.23 0 0.083 Q8NF91 V4546I Polymorphism NA 0.148 0.47 0 0.121 Q8NFA0 H76Y Polymorphism 0.283 0.259 NA 49 0.421 Q8NFA0 A1469G Polymorphism NA 0.193 0.06 26 0.171 Q8NFA0 T1578I Polymorphism NA 0.178 0.05 -16 0.078 Q8NFB2 C243S Polymorphism 0.117 0.304 0.21 -6 0.169 Q8NFC6 G2361S Polymorphism NA 0.062 0.00 31 0.071 Q8NFC6 T1515A Polymorphism NA 0.041 NA -10 0.029 Q8NFC6 V1645I Polymorphism NA 0.050 0.27 -43 0.036 Q8NFD2 D4Y Polymorphism NA 0.077 0.01 34 0.135 Q8NFD2 E426K Polymorphism 0.631 0.264 1.00 -3 0.418 Q8NFD2 G318R Polymorphism NA 0.348 0.58 21 0.327 Q8NFD2 G442R Polymorphism 0.119 0.244 0.44 32 0.163 Q8NFD2 H490R Polymorphism 0.155 0.227 0.70 -25 0.145 Q8NFD2 P596L Polymorphism 0.563 0.241 0.00 39 0.545 Q8NFD2 R122H Polymorphism NA 0.639 0.02 34 0.525 Q8NFD2 S670G Polymorphism 0.073 0.240 0.71 -34 0.115 Q8NFD2 T595I Polymorphism 0.597 0.231 0.01 60 0.664 Q8NFI3 E731K Polymorphism NA 0.135 0.60 13 0.135 Q8NFI3 S596N Polymorphism 0.249 0.074 0.61 -11 0.067 Q8NFJ5 C9F Polymorphism 0.915 0.920 0.00 56 0.919 Q8NFJ5 S118G Polymorphism 0.212 0.201 0.57 13 0.235 Q8NFJ5 T182A Polymorphism 0.161 0.333 0.12 15 0.311 Q8NFJ6 R85C Polymorphism 0.820 0.813 0.00 53 0.908 Q8NFJ6 R85H Disease 0.634 0.630 0.14 38 0.571 Q8NFJ6 L173R Disease 0.668 0.619 0.02 53 0.853 Q8NFJ6 M323I Disease 0.261 0.895 0.08 50 0.787 Q8NFJ6 P290S Disease 0.998 0.911 0.00 43 0.926 Q8NFJ6 Q210R Disease 0.362 0.545 0.04 41 0.576 Q8NFJ6 R164Q Disease 0.267 0.766 0.03 35 0.523 Q8NFJ6 R268C Polymorphism 0.820 0.771 0.00 37 0.859 Q8NFJ6 T335M Polymorphism 0.664 0.186 0.04 31 0.255 Q8NFJ6 W178S Disease 0.685 0.821 0.00 64 0.906 Q8NFJ9 H35R Disease 0.340 0.298 NA 21 0.259 Q8NFJ9 K53E Disease 0.341 0.472 NA 19 0.531 Q8NFJ9 D148N Disease 0.364 0.157 NA 12 0.149 Q8NFJ9 E234K Disease 0.255 0.336 NA 17 0.333 Q8NFJ9 G305S Disease 0.214 0.274 NA -1 0.210 Q8NFJ9 L503H Disease NA 0.494 NA 47 0.723 Q8NFJ9 L518P Disease NA 0.835 NA 22 0.592 Q8NFJ9 L518Q Disease NA 0.389 NA 0 0.400 Q8NFJ9 M390R Disease 0.608 0.612 NA 46 0.747 Q8NFJ9 R160Q Disease 0.342 0.192 NA 7 0.239 Q8NFJ9 Y434S Disease 0.757 0.724 NA 40 0.818 Q8NFM7 T255M Polymorphism NA 0.055 0.05 39 0.075 Q8NFP4 L61P Polymorphism NA 0.411 0.06 47 0.355 Q8NFP9 I2501V Polymorphism 0.667 0.632 0.08 18 0.771 Q8NFQ5 T16M Polymorphism NA 0.188 0.02 35 0.192 Q8NFQ5 P149T Polymorphism 0.153 0.130 0.11 50 0.235 Q8NFQ5 S347G Polymorphism 0.188 0.072 0.60 -3 0.076 Q8NFQ6 E479A Polymorphism 0.157 0.159 0.18 31 0.264 Q8NFQ6 S451P Polymorphism 0.111 0.262 1.00 -34 0.015 Q8NFQ6 V269A Polymorphism 0.116 0.122 0.77 -19 0.106 Q8NFQ6 V302L Polymorphism 0.180 0.056 1.00 -2 0.025 Q8NFR7 M157V Polymorphism 0.101 0.054 0.61 -14 0.045 Q8NFR9 S417T Polymorphism NA 0.017 1.00 -31 0.015 Q8NFT2 R456Q Polymorphism 0.301 0.253 0.11 19 0.355 Q8NFT8 P433L Polymorphism 0.213 0.204 0.02 6 0.271 Q8NFU0 Y62C Polymorphism 0.366 0.470 0.00 47 0.630 Q8NFU0 Q331E Polymorphism 0.581 0.653 0.73 -3 0.486 Q8NFU7 I1123M Polymorphism 0.146 0.087 NA -17 0.023 Q8NFU7 N1018S Polymorphism 0.324 0.109 NA -13 0.057 Q8NFW1 P703T Polymorphism NA 0.614 0.65 20 0.423 Q8NFY4 S478N Polymorphism NA 0.144 0.32 -1 0.185 Q8NFY9 C420R Polymorphism 0.498 0.521 0.61 39 0.359 Q8NG06 W3S Polymorphism NA 0.115 0.88 -37 0.069 Q8NG06 V322I Polymorphism 0.157 0.065 0.35 5 0.152 Q8NG08 L191P Polymorphism NA 0.155 NA -21 0.010 Q8NG08 L267F Polymorphism NA 0.196 0.00 -30 0.267 Q8NG27 E606D Polymorphism 0.271 0.537 1.00 -22 0.347 Q8NG31 A486S Polymorphism NA 0.035 0.16 -38 0.017 Q8NG31 R936G Polymorphism NA 0.063 1.00 12 0.019 Q8NG31 T113A Polymorphism NA 0.036 NA -42 0.015 Q8NG31 T1473A Polymorphism NA 0.046 0.59 -15 0.034 Q8NG48 I29V Polymorphism 0.132 0.207 NA 31 0.099 Q8NG48 A331V Polymorphism 0.195 0.151 NA -5 0.119 Q8NG48 E641D Polymorphism 0.071 0.021 NA -26 0.019 Q8NG48 I541V Polymorphism 0.120 0.111 NA 7 0.065 Q8NG48 S472T Polymorphism 0.512 0.055 NA 13 0.077 Q8NG50 H32R Polymorphism NA 0.098 0.43 12 0.073 Q8NG50 C127W Polymorphism NA 0.252 1.00 -4 0.053 Q8NG57 L375P Polymorphism 0.942 0.973 0.00 57 0.979 Q8NG66 I263V Polymorphism 0.577 0.148 0.02 -23 0.339 Q8NG66 V562A Polymorphism NA 0.062 0.74 -29 0.026 Q8NG66 Y123C Polymorphism 0.533 0.685 0.16 -7 0.503 Q8NG75 S164G Polymorphism 0.224 0.092 1.00 -36 0.139 Q8NG76 A169V Polymorphism 0.220 0.725 0.05 -3 0.561 Q8NG77 T104S Polymorphism 0.130 0.227 0.66 -24 0.229 Q8NG81 F35L Polymorphism 0.228 0.920 0.01 33 0.659 Q8NG81 V78A Polymorphism 0.619 0.553 0.01 -2 0.539 Q8NG81 C178F Polymorphism 0.545 0.293 1.00 -8 0.009 Q8NG85 S104L Polymorphism 0.549 0.433 1.00 -45 0.322 Q8NG92 Y266S Polymorphism 0.057 0.142 1.00 10 0.094 Q8NG95 M29V Polymorphism 0.135 0.319 0.69 -38 0.068 Q8NG98 S75C Polymorphism 0.605 0.679 0.02 22 0.603 Q8NG98 A279D Polymorphism 0.378 0.926 0.00 48 0.862 Q8NG98 C139R Polymorphism 0.214 0.481 1.00 18 0.213 Q8NG98 C139Y Polymorphism 0.182 0.794 0.14 24 0.414 Q8NG98 H131Q Polymorphism 0.093 0.810 0.03 42 0.358 Q8NG98 L292M Polymorphism 0.566 0.862 0.03 26 0.717 Q8NG98 M136I Polymorphism 0.204 0.776 0.01 61 0.714 Q8NG98 T133M Polymorphism 0.207 0.505 0.20 7 0.386 Q8NG99 F281V Polymorphism 0.454 0.183 1.00 -35 0.119 Q8NGA0 S167F Polymorphism 0.838 0.888 0.07 37 0.904 Q8NGA0 W141C Polymorphism 0.563 0.220 1.00 -29 0.026 Q8NGA0 Y252C Polymorphism 0.942 0.903 0.01 61 0.900 Q8NGA5 H144R Polymorphism 0.203 0.441 0.80 -2 0.168 Q8NGA5 N100K Polymorphism 0.238 0.711 0.45 39 0.631 Q8NGB6 D121N Polymorphism 0.988 0.904 0.00 63 0.938 Q8NGB6 R284H Polymorphism 0.303 0.584 0.00 11 0.492 Q8NGC0 V80M Polymorphism 0.123 0.294 0.20 -42 0.239 Q8NGC0 L117F Polymorphism 0.971 0.858 0.00 47 0.923 Q8NGC1 V116I Polymorphism 0.178 0.164 0.22 2 0.221 Q8NGC2 Q234R Polymorphism 0.335 0.245 0.77 6 0.172 Q8NGC2 V118M Polymorphism 0.380 0.368 1.00 -42 0.080 Q8NGC3 L67F Polymorphism 0.158 0.184 1.00 -41 0.144 Q8NGC3 R85L Polymorphism 0.539 0.783 0.01 41 0.622 Q8NGC3 R187P Polymorphism 0.489 0.632 1.00 10 0.275 Q8NGC3 R209G Polymorphism 0.516 0.266 1.00 -10 0.012 Q8NGC4 S73G Polymorphism 0.099 0.273 0.43 -18 0.138 Q8NGC7 L32V Polymorphism 0.611 0.883 0.02 54 0.908 Q8NGC7 C259R Polymorphism 0.990 0.970 0.00 78 0.950 Q8NGC7 I107T Polymorphism 0.355 0.140 0.61 -26 0.143 Q8NGC7 L195F Polymorphism 0.225 0.155 1.00 -19 0.099 Q8NGC7 R146H Polymorphism 0.283 0.297 0.69 11 0.335 Q8NGC7 Y236H Polymorphism 0.971 0.877 0.00 82 0.940 Q8NGD1 I76T Polymorphism 0.347 0.122 0.45 -28 0.179 Q8NGD1 V135L Polymorphism 0.175 0.516 0.04 15 0.259 Q8NGD3 R319K Polymorphism NA 0.125 NA 31 0.047 Q8NGD4 R304H Polymorphism 0.129 0.644 0.15 31 0.246 Q8NGD5 L145R Polymorphism 0.918 0.935 0.00 55 0.935 Q8NGD5 M119V Polymorphism 0.867 0.911 0.03 53 0.926 Q8NGE0 F275V Polymorphism 0.361 0.132 1.00 -29 0.110 Q8NGE0 R166Q Polymorphism 0.404 0.445 0.33 3 0.349 Q8NGE0 Y279H Polymorphism 0.495 0.795 0.00 62 0.870 Q8NGE3 V200M Polymorphism 0.410 0.646 0.26 -18 0.433 Q8NGE5 G96S Polymorphism 0.804 0.864 0.02 33 0.735 Q8NGE7 R45C Polymorphism 0.540 0.545 0.11 22 0.561 Q8NGE7 E103A Polymorphism 0.313 0.243 0.30 18 0.109 Q8NGE7 R207H Polymorphism 0.352 0.396 0.13 5 0.310 Q8NGF0 L111H Polymorphism 0.202 0.655 0.26 15 0.276 Q8NGF0 V288I Polymorphism 0.114 0.068 0.42 2 0.091 Q8NGF3 I89V Polymorphism 0.083 0.108 0.11 -20 0.160 Q8NGF4 A105T Polymorphism 0.139 0.457 0.39 -31 0.228 Q8NGF6 R263Q Polymorphism 0.183 0.538 0.09 -9 0.249 Q8NGF7 L80I Polymorphism 0.100 0.810 0.01 25 0.460 Q8NGF7 Y308C Polymorphism 0.137 0.644 0.13 21 0.344 Q8NGF8 C63Y Polymorphism 0.122 0.748 1.00 -15 0.217 Q8NGG0 N57T Polymorphism 0.417 0.049 1.00 -51 0.064 Q8NGG0 V87I Polymorphism 0.252 0.165 0.47 3 0.238 Q8NGG0 V208F Polymorphism 0.101 0.874 0.30 -19 0.142 Q8NGG2 S21Y Polymorphism NA 0.133 NA 39 0.035 Q8NGG2 T64I Polymorphism 0.248 0.389 0.85 -67 0.188 Q8NGG2 V87L Polymorphism 0.110 0.208 1.00 -25 0.136 Q8NGG2 H309D Polymorphism 0.230 0.798 0.13 30 0.731 Q8NGG2 L238V Polymorphism 0.222 0.507 0.50 -30 0.343 Q8NGG3 W84G Polymorphism 0.139 0.363 0.15 33 0.375 Q8NGG4 E22V Polymorphism 0.602 0.782 0.38 43 0.723 Q8NGG5 M21V Polymorphism 0.079 0.412 0.16 3 0.227 Q8NGG5 P27T Polymorphism 0.368 0.859 0.08 30 0.584 Q8NGG8 M114I Polymorphism 0.113 0.490 0.20 -10 0.146 Q8NGH3 L82I Polymorphism 0.371 0.801 0.00 50 0.872 Q8NGH3 W165S Polymorphism 0.810 0.834 0.00 63 0.915 Q8NGH9 F49L Polymorphism 0.120 0.555 1.00 -22 0.168 Q8NGH9 F257L Polymorphism 0.112 0.620 1.00 -12 0.210 Q8NGH9 R184M Polymorphism 0.425 0.305 0.47 -7 0.092 Q8NGH9 R228H Polymorphism 0.191 0.527 0.15 6 0.339 Q8NGH9 V176I Polymorphism 0.219 0.029 1.00 -7 0.039 Q8NGI0 H264R Polymorphism 0.665 0.886 0.70 39 0.871 Q8NGI0 S249A Polymorphism 0.256 0.128 0.58 -38 0.133 Q8NGI7 Q123R Polymorphism 0.840 0.144 1.00 0 0.094 Q8NGI9 F103L Polymorphism 0.564 0.802 0.57 -4 0.464 Q8NGJ1 F102S Polymorphism 0.855 0.880 0.00 32 0.900 Q8NGJ1 M263T Polymorphism 0.409 0.169 1.00 -12 0.111 Q8NGJ1 S151T Polymorphism 0.196 0.307 0.11 -18 0.175 Q8NGJ2 A89T Polymorphism 0.193 0.316 0.02 -12 0.181 Q8NGJ2 V47I Polymorphism 0.169 0.156 0.38 -35 0.185 Q8NGJ2 G235C Polymorphism 0.441 0.756 0.08 -3 0.435 Q8NGJ4 N5S Polymorphism NA 0.844 0.71 18 0.570 Q8NGJ5 A207V Polymorphism 0.125 0.531 0.78 -33 0.084 Q8NGJ6 D72N Polymorphism 0.912 0.769 0.01 53 0.917 Q8NGJ6 R267G Polymorphism 0.099 0.737 0.19 30 0.177 Q8NGJ6 T288M Polymorphism 0.184 0.231 0.19 -45 0.070 Q8NGJ7 G59E Polymorphism 0.192 0.550 1.00 -26 0.229 Q8NGJ8 L178R Polymorphism 0.054 0.443 0.86 6 0.053 Q8NGJ8 L264F Polymorphism 0.386 0.293 0.80 -48 0.149 Q8NGK0 A94E Polymorphism 0.474 0.827 0.68 20 0.789 Q8NGK0 E96Q Polymorphism 0.268 0.769 0.12 22 0.495 Q8NGK1 I195T Polymorphism 0.199 0.126 0.54 8 0.150 Q8NGK1 R124H Polymorphism 0.484 0.904 0.02 64 0.902 Q8NGK1 S114L Polymorphism 0.716 0.848 0.03 29 0.875 Q8NGK1 Y125S Polymorphism 0.406 0.758 0.00 59 0.868 Q8NGK2 T139I Polymorphism 0.757 0.827 0.02 53 0.909 Q8NGK3 R124C Polymorphism 0.644 0.938 0.07 64 0.862 Q8NGK5 S9L Polymorphism 0.192 0.453 0.77 45 0.347 Q8NGK5 S305R Polymorphism 0.266 0.190 0.49 5 0.156 Q8NGK6 T41I Polymorphism 0.108 0.396 0.54 -40 0.158 Q8NGL0 M81R Polymorphism 0.795 0.929 0.00 65 0.933 Q8NGL1 Y36C Polymorphism 0.944 0.900 0.00 62 0.936 Q8NGL1 N136D Polymorphism 0.188 0.263 0.65 33 0.274 Q8NGL2 I46F Polymorphism 0.587 0.915 0.03 25 0.732 Q8NGL2 S287P Polymorphism 0.479 0.148 1.00 -69 0.092 Q8NGL3 L290P Polymorphism 0.718 0.895 0.00 35 0.886 Q8NGL4 C62Y Polymorphism 0.697 0.241 1.00 -25 0.004 Q8NGL4 R236L Polymorphism 0.197 0.924 0.00 57 0.643 Q8NGL6 A287V Polymorphism 0.123 0.393 1.00 -24 0.237 Q8NGL9 T49A Polymorphism 0.090 0.135 0.53 2 0.121 Q8NGL9 A203T Polymorphism 0.275 0.238 0.16 -25 0.283 Q8NGL9 L259P Polymorphism 0.262 0.280 1.00 -29 0.078 Q8NGM9 I92V Polymorphism 0.340 0.473 0.00 61 0.627 Q8NGM9 L55R Polymorphism 0.959 0.911 0.00 69 0.940 Q8NGM9 C120Y Polymorphism 0.714 0.344 1.00 -18 0.008 Q8NGM9 F200L Polymorphism 0.239 0.786 0.50 -10 0.400 Q8NGM9 R133K Polymorphism 0.169 0.307 0.30 4 0.074 Q8NGM9 R298K Polymorphism 0.282 0.158 1.00 -41 0.105 Q8NGN1 I23T Polymorphism 0.331 0.267 0.02 -4 0.228 Q8NGN2 G63S Polymorphism 0.127 0.323 0.84 -13 0.164 Q8NGN3 L24P Polymorphism 0.167 0.760 0.19 10 0.231 Q8NGN3 K295Q Polymorphism 0.526 0.852 0.02 21 0.580 Q8NGN3 M134V Polymorphism 0.125 0.414 0.43 26 0.162 Q8NGN3 R226Q Polymorphism 0.477 0.790 0.09 25 0.543 Q8NGN3 V195E Polymorphism 0.489 0.602 1.00 15 0.294 Q8NGN3 Y101C Polymorphism 0.914 0.836 0.00 14 0.869 Q8NGN4 H228R Polymorphism 0.378 0.500 1.00 4 0.392 Q8NGN4 Q172R Polymorphism 0.166 0.479 0.46 18 0.169 Q8NGN4 S136T Polymorphism 0.101 0.447 0.39 -9 0.217 Q8NGN6 T5S Polymorphism 0.095 0.347 0.59 0 0.227 Q8NGN6 G20A Polymorphism 0.104 0.449 0.71 -19 0.160 Q8NGN6 T90A Polymorphism 0.228 0.445 0.68 16 0.352 Q8NGP3 K270R Polymorphism 0.558 0.794 0.06 -2 0.512 Q8NGP4 L84F Polymorphism 0.424 0.741 0.14 6 0.480 Q8NGP4 G163S Polymorphism 0.124 0.341 0.90 -24 0.140 Q8NGP8 S282T Polymorphism 0.387 0.373 0.03 -25 0.220 Q8NGQ3 V225A Polymorphism 0.107 0.372 0.48 -24 0.160 Q8NGQ3 V225I Polymorphism 0.205 0.196 0.33 -31 0.176 Q8NGQ5 R159L Polymorphism 0.447 0.869 0.17 -8 0.487 Q8NGR2 M259I Polymorphism 0.243 0.239 0.59 -22 0.087 Q8NGR5 G234R Polymorphism 0.864 0.924 0.02 55 0.847 Q8NGR5 Y310H Polymorphism NA 0.144 0.55 -5 0.079 Q8NGR6 A230T Polymorphism 0.064 0.427 0.82 -2 0.218 Q8NGR8 R211P Polymorphism 0.252 0.582 1.00 14 0.242 Q8NGR9 T301M Polymorphism 0.279 0.153 1.00 -35 0.095 Q8NGR9 V244G Polymorphism 0.096 0.648 0.11 4 0.056 Q8NGS0 P18S Polymorphism 0.121 0.140 0.86 -17 0.134 Q8NGS3 N318S Polymorphism NA 0.085 NA -11 0.028 Q8NGS6 K293T Polymorphism 0.509 0.433 0.42 51 0.586 Q8NGS8 L69M Polymorphism 0.396 0.592 0.05 -24 0.477 Q8NGS8 L86V Polymorphism 0.288 0.546 0.51 -1 0.356 Q8NGS8 S18F Polymorphism 0.472 0.844 0.06 16 0.532 Q8NGS8 C189Y Polymorphism 0.983 0.974 0.00 70 0.947 Q8NGS8 I282V Polymorphism 0.128 0.034 0.19 -18 0.105 Q8NGS8 M290T Polymorphism 0.517 0.851 0.23 31 0.575 Q8NGS8 N195S Polymorphism 0.254 0.734 0.29 30 0.468 Q8NGS9 S160T Polymorphism 0.266 0.099 1.00 -49 0.158 Q8NGT0 T91S Polymorphism 0.278 0.426 0.20 11 0.358 Q8NGT2 H133R Polymorphism 0.159 0.464 0.37 29 0.390 Q8NGT5 R53H Polymorphism 0.231 0.500 0.67 12 0.372 Q8NGV0 V154M Polymorphism 0.502 0.682 0.19 -32 0.409 Q8NGV5 L64V Polymorphism 0.381 0.630 0.02 5 0.520 Q8NGV5 Q191H Polymorphism 0.253 0.337 0.58 -12 0.285 Q8NGV5 S277L Polymorphism 0.582 0.143 1.00 -52 0.086 Q8NGV6 C195R Polymorphism 0.954 0.924 0.00 83 0.937 Q8NGV7 I286V Polymorphism 0.226 0.034 1.00 -21 0.079 Q8NGV7 R266C Polymorphism 0.393 0.750 0.01 40 0.678 Q8NGW6 E39D Polymorphism 0.402 0.867 0.05 9 0.511 Q8NGW6 H49Y Polymorphism 0.102 0.786 0.64 5 0.273 Q8NGW6 C197R Polymorphism 0.990 0.956 0.00 79 0.948 Q8NGW6 K320R Polymorphism 0.255 0.093 1.00 -21 0.147 Q8NGW6 P211L Polymorphism 0.902 0.865 0.00 50 0.863 Q8NGW6 S134L Polymorphism 0.811 0.356 0.70 -24 0.558 Q8NGX0 A142T Polymorphism 0.267 0.136 0.67 -44 0.123 Q8NGX0 F117L Polymorphism 0.113 0.696 0.29 -38 0.102 Q8NGX0 R171P Polymorphism 0.082 0.788 0.37 -3 0.093 Q8NGX3 I78V Polymorphism 0.328 0.131 0.61 7 0.151 Q8NGX3 V16A Polymorphism 0.312 0.536 0.03 33 0.521 Q8NGX3 I137M Polymorphism 0.640 0.070 1.00 -27 0.044 Q8NGX3 K312N Polymorphism 0.232 0.354 0.07 39 0.466 Q8NGY0 A81S Polymorphism 0.255 0.401 0.62 -35 0.187 Q8NGY0 I60T Polymorphism 0.217 0.123 0.12 -33 0.227 Q8NGY0 S172P Polymorphism 0.866 0.909 0.02 23 0.835 Q8NGY1 N294T Polymorphism 0.770 0.899 0.00 59 0.928 Q8NGY2 R6Q Polymorphism 0.162 0.114 0.30 14 0.181 Q8NGY2 I159F Polymorphism 0.724 0.602 0.02 11 0.778 Q8NGY3 G20R Polymorphism 0.185 0.562 0.53 12 0.260 Q8NGY3 P264L Polymorphism 0.515 0.500 0.71 -33 0.253 Q8NGY5 A10T Polymorphism 0.129 0.125 1.00 -38 0.098 Q8NGY5 F245L Polymorphism 0.353 0.225 1.00 -37 0.143 Q8NGY5 I194T Polymorphism 0.113 0.152 0.71 12 0.133 Q8NGY5 R293H Polymorphism 0.513 0.900 0.01 52 0.899 Q8NGY6 A204V Polymorphism 0.152 0.520 0.99 -27 0.135 Q8NGY9 A202T Polymorphism 0.170 0.405 0.27 -30 0.183 Q8NGY9 G196C Polymorphism 0.445 0.543 0.13 16 0.646 Q8NGY9 K294R Polymorphism 0.565 0.791 0.12 -9 0.520 Q8NGZ3 I132V Polymorphism 0.099 0.168 0.52 30 0.181 Q8NGZ4 L164S Polymorphism 0.685 0.435 0.01 18 0.654 Q8NGZ5 P24A Polymorphism 0.754 0.689 0.18 16 0.680 Q8NGZ5 L167P Polymorphism 0.867 0.852 0.01 46 0.863 Q8NGZ5 R236G Polymorphism 0.713 0.235 1.00 11 0.193 Q8NGZ5 V120L Polymorphism 0.591 0.718 0.04 -6 0.526 Q8NGZ6 F215L Polymorphism 0.207 0.251 1.00 -29 0.167 Q8NGZ6 P159A Polymorphism 0.392 0.530 0.31 0 0.454 Q8NH01 Q309R Polymorphism 0.140 0.113 0.38 18 0.139 Q8NH03 M204T Polymorphism 0.395 0.278 0.02 13 0.400 Q8NH04 L36V Polymorphism 0.308 0.626 0.37 -34 0.423 Q8NH05 F238L Polymorphism 0.404 0.247 1.00 -7 0.182 Q8NH10 S112C Polymorphism 0.135 0.132 1.00 -48 0.105 Q8NH18 M136I Polymorphism 0.684 0.879 0.04 64 0.811 Q8NH40 T42I Polymorphism 0.390 0.416 0.49 0 0.309 Q8NH40 R237H Polymorphism 0.561 0.918 0.07 53 0.894 Q8NH40 V156I Polymorphism 0.102 0.207 0.42 -38 0.140 Q8NH41 I310M Polymorphism 0.820 0.803 0.00 30 0.891 Q8NH43 D2N Polymorphism 0.178 0.180 0.31 -76 0.217 Q8NH43 R52S Polymorphism 0.180 0.213 0.55 -3 0.087 Q8NH43 S93F Polymorphism 0.961 0.930 0.00 66 0.945 Q8NH43 G109S Polymorphism 0.503 0.796 0.15 -14 0.585 Q8NH43 M101K Polymorphism 0.689 0.935 0.00 50 0.923 Q8NH48 P30L Polymorphism 0.411 0.249 1.00 -54 0.088 Q8NH48 G247A Polymorphism 0.165 0.537 0.19 -45 0.191 Q8NH48 I198V Polymorphism 0.112 0.091 0.25 -32 0.162 Q8NH48 K296R Polymorphism 0.311 0.708 0.03 27 0.590 Q8NH49 L196Q Polymorphism 0.750 0.809 0.01 10 0.844 Q8NH49 P282S Polymorphism 0.864 0.913 0.00 42 0.858 Q8NH50 F68S Polymorphism 0.179 0.867 0.34 16 0.684 Q8NH51 I275M Polymorphism 0.546 0.590 0.03 25 0.575 Q8NH55 D209G Polymorphism 0.581 0.902 0.10 46 0.886 Q8NH55 E309K Polymorphism 0.131 0.118 0.90 -1 0.082 Q8NH59 F308S Polymorphism 0.394 0.283 0.02 32 0.432 Q8NH59 R178H Polymorphism 0.192 0.129 1.00 -37 0.096 Q8NH59 V155I Polymorphism 0.187 0.124 0.51 -23 0.160 Q8NH60 V226I Polymorphism 0.358 0.643 1.00 0 0.420 Q8NH64 E8K Polymorphism 0.389 0.348 0.89 24 0.305 Q8NH64 V196A Polymorphism 0.302 0.351 0.25 10 0.220 Q8NH67 I74L Polymorphism 0.087 0.247 1.00 -34 0.159 Q8NH67 I178V Polymorphism 0.063 0.130 0.47 -45 0.100 Q8NH67 I183V Polymorphism 0.072 0.058 1.00 -38 0.032 Q8NH69 F39L Polymorphism 0.358 0.460 1.00 -56 0.101 Q8NH69 H65R Polymorphism 0.392 0.798 0.04 43 0.805 Q8NH69 M160T Polymorphism 0.339 0.145 1.00 -39 0.094 Q8NH69 R189C Polymorphism 0.383 0.155 1.00 -24 0.100 Q8NH70 H232R Polymorphism 0.252 0.174 1.00 7 0.137 Q8NH70 K303M Polymorphism 0.172 0.379 0.21 33 0.383 Q8NH72 I133T Polymorphism 0.256 0.746 0.07 32 0.493 Q8NH73 S72T Polymorphism 0.430 0.583 0.06 -14 0.445 Q8NH74 A117V Polymorphism 0.294 0.443 1.00 -27 0.284 Q8NH74 L287P Polymorphism 0.476 0.231 1.00 -49 0.088 Q8NH76 P277S Polymorphism 0.455 0.430 0.11 -2 0.416 Q8NH79 T190N Polymorphism 0.730 0.876 0.02 65 0.909 Q8NH83 N6S Polymorphism 0.425 0.592 0.79 -23 0.436 Q8NH85 C122R Polymorphism 0.526 0.269 1.00 23 0.047 Q8NH85 I162T Polymorphism 0.142 0.154 0.39 -2 0.149 Q8NH85 Y132H Polymorphism 0.987 0.856 0.00 80 0.942 Q8NH87 C98G Polymorphism 0.199 0.636 0.00 31 0.515 Q8NH87 T62I Polymorphism 0.371 0.658 0.03 -22 0.385 Q8NH87 A259S Polymorphism 0.107 0.287 0.12 -26 0.140 Q8NH87 E185K Polymorphism 0.173 0.313 1.00 -13 0.161 Q8NH87 K231Q Polymorphism 0.114 0.500 0.10 -6 0.101 Q8NH87 V117M Polymorphism 0.169 0.258 1.00 -55 0.066 Q8NH87 Y233H Polymorphism 0.279 0.775 0.03 -7 0.416 Q8NH90 G4V Polymorphism 0.153 0.558 0.25 13 0.647 Q8NH90 S43T Polymorphism 0.124 0.434 0.00 -11 0.095 Q8NH92 H135R Polymorphism 0.154 0.174 1.00 -2 0.098 Q8NH92 I123T Polymorphism 0.166 0.109 0.26 -34 0.203 Q8NH92 L206M Polymorphism 0.073 0.237 0.22 4 0.217 Q8NH93 R54G Polymorphism 0.543 0.717 0.03 35 0.858 Q8NH94 G349R Polymorphism 0.633 0.909 0.00 30 0.910 Q8NH94 L308V Polymorphism 0.251 0.201 1.00 -42 0.179 Q8NH94 T149A Polymorphism 0.082 0.367 0.48 8 0.231 Q8NHH9 D420H Polymorphism 0.186 0.133 0.09 -6 0.212 Q8NHH9 N272S Polymorphism 0.117 0.174 0.39 -10 0.167 Q8NHJ6 F5L Polymorphism NA 0.235 1.00 -68 0.164 Q8NHJ6 R18S Polymorphism NA 0.709 0.49 -13 0.478 Q8NHJ6 K362T Polymorphism 0.506 0.251 0.04 -32 0.117 Q8NHJ6 N335D Polymorphism 0.424 0.152 0.89 -26 0.090 Q8NHJ6 Q414R Polymorphism 0.374 0.550 0.00 59 0.764 Q8NHL6 A93T Polymorphism 0.196 0.694 0.41 0 0.191 Q8NHL6 L68P Polymorphism 0.082 0.753 0.31 -38 0.165 Q8NHL6 L620F Polymorphism NA 0.144 0.49 9 0.198 Q8NHL6 S155I Polymorphism 0.179 0.168 0.83 -28 0.103 Q8NHQ9 E154G Polymorphism 0.276 0.348 0.46 17 0.356 Q8NHQ9 N264S Polymorphism 0.146 0.077 1.00 -40 0.065 Q8NHQ9 V101L Polymorphism 0.569 0.472 0.00 35 0.596 Q8NHS0 M153L Polymorphism 0.021 0.138 0.35 14 0.060 Q8NHS3 G52R Disease 0.607 0.770 0.01 59 0.868 Q8NHS3 A157P Disease 0.911 0.933 0.01 68 0.937 Q8NHS3 G310D Disease 0.959 0.873 0.00 66 0.951 Q8NHS3 G385R Polymorphism NA 0.139 0.17 51 0.158 Q8NHS3 G429D Disease 0.966 0.829 0.00 65 0.938 Q8NHS3 P447L Disease 0.961 0.811 0.00 42 0.897 Q8NHS3 R139H Disease 0.972 0.906 0.00 63 0.957 Q8NHS3 R465W Disease 0.968 0.679 0.00 56 0.933 Q8NHS3 T294K Disease 0.906 0.477 0.13 57 0.789 Q8NHS3 V109G Polymorphism 0.878 0.583 0.12 36 0.853 Q8NHS3 Y121C Disease 0.993 0.931 0.14 22 0.940 Q8NHS4 A503V Polymorphism 0.148 0.038 1.00 -32 0.013 Q8NHS9 Q155R Polymorphism NA 0.026 0.00 43 0.110 Q8NHS9 R112T Polymorphism NA 0.175 0.00 54 0.062 Q8NHU2 P74R Polymorphism 0.060 0.616 NA 61 0.706 Q8NHU2 D505E Polymorphism 0.197 0.500 NA 26 0.436 Q8NHU2 P371L Polymorphism 0.457 0.151 NA 12 0.140 Q8NHU3 T21M Polymorphism NA 0.043 0.03 19 0.105 Q8NHU6 V150A Polymorphism 0.475 0.072 0.02 14 0.102 Q8NHX9 L564P Polymorphism 0.104 0.712 0.23 16 0.217 Q8NHX9 M484L Polymorphism 0.058 0.854 0.43 -31 0.218 Q8NHY3 A540T Polymorphism NA 0.151 0.17 32 0.143 Q8NHY3 A654V Polymorphism NA 0.031 NA -23 0.004 Q8NHY5 H130Q Polymorphism 0.947 0.843 0.38 47 0.891 Q8NHY6 A620V Polymorphism 0.580 0.548 0.13 11 0.637 Q8NI08 G533R Polymorphism 0.650 0.208 0.35 35 0.137 Q8NI17 S497N Polymorphism 0.484 0.299 0.31 34 0.364 Q8NI22 D129E Disease 0.579 0.803 0.00 56 0.875 Q8NI22 I136T Disease 0.716 0.700 0.03 57 0.885 Q8NI35 C744R Polymorphism 0.061 0.254 0.11 54 0.308 Q8NI35 E362A Polymorphism 0.771 0.540 0.11 41 0.706 Q8NI35 E779K Polymorphism 0.643 0.223 0.49 54 0.509 Q8NI35 G303R Polymorphism 0.821 0.792 0.25 60 0.797 Q8NI35 I870M Polymorphism 0.051 0.186 0.14 -47 0.031 Q8NI35 A1504P Polymorphism 0.506 0.849 0.07 57 0.817 Q8NI35 G1178S Polymorphism 0.095 0.267 0.84 18 0.190 Q8NI35 V1360L Polymorphism 0.044 0.142 0.59 -39 0.068 Q8NI36 A449T Disease NA 0.625 0.49 5 0.456 Q8NI36 D658G Disease NA 0.727 0.43 42 0.559 Q8NI36 I264V Polymorphism 0.126 0.301 1.00 -1 0.232 Q8NI36 N355S Disease 0.306 0.755 0.48 31 0.535 Q8NI36 R529Q Disease NA 0.721 0.61 59 0.636 Q8NI38 V29A Polymorphism NA 0.064 0.57 2 0.033 Q8NI51 E50Q Polymorphism NA 0.067 0.30 2 0.030 Q8NI51 Q525E Polymorphism 0.115 0.227 0.28 23 0.263 Q8NI51 R448H Polymorphism NA 0.230 0.01 41 0.481 Q8NI60 E551K Disease 0.659 0.430 0.03 53 0.701 Q8NI60 G272D Disease 0.989 0.854 0.17 62 0.941 Q8NI60 G272V Disease 0.976 0.822 0.14 42 0.928 Q8NI60 G549S Disease 0.622 0.670 0.10 20 0.578 Q8NI60 R213W Disease 0.995 0.948 0.00 74 0.955 Q8NI60 Y514C Disease 0.890 0.843 0.02 54 0.915 Q8NI77 T273A Polymorphism 0.191 0.299 0.56 -52 0.153 Q8TA86 D170G Disease NA 0.082 NA 20 0.037 Q8TA86 H137L Disease NA 0.650 NA 7 0.635 Q8TA86 K210R Polymorphism NA 0.063 NA 42 0.056 Q8TAA1 P5S Polymorphism NA 0.056 NA -67 0.015 Q8TAA1 T74S Polymorphism NA 0.053 NA -41 0.015 Q8TAA9 E347A Polymorphism 0.773 0.521 0.00 39 0.800 Q8TAA9 M328T Disease 0.166 0.196 0.06 17 0.207 Q8TAA9 R274Q Disease 0.702 0.774 0.00 16 0.798 Q8TAA9 V239I Disease 0.411 0.231 0.00 -3 0.257 Q8TAB3 N557K Disease 0.998 0.679 0.00 65 0.963 Q8TAB3 V441E Disease 0.452 0.623 0.00 59 0.754 Q8TAF7 N87S Polymorphism NA 0.195 0.74 -13 0.193 Q8TAF8 R176L Disease 0.880 0.965 0.23 54 0.950 Q8TAF8 T165M Disease 0.867 0.543 0.00 30 0.734 Q8TAF8 Y127C Disease 0.913 0.910 0.12 31 0.863 Q8TAG9 L523V Polymorphism 0.261 0.270 1.00 -33 0.241 Q8TAG9 T396I Polymorphism 0.596 0.067 1.00 -33 0.018 Q8TAK5 V62I Polymorphism 0.122 0.292 0.14 -44 0.141 Q8TAM1 C91W Disease NA 0.608 0.01 49 0.700 Q8TAM1 R34P Disease NA 0.716 0.21 35 0.726 Q8TAM1 R49W Disease NA 0.453 0.01 53 0.598 Q8TAM1 C195W Disease NA 0.724 0.00 61 0.833 Q8TAM1 G677V Disease NA 0.633 0.00 58 0.709 Q8TAM1 K579R Disease NA 0.111 0.00 18 0.113 Q8TAM1 L170S Disease NA 0.326 0.00 45 0.191 Q8TAM1 L308F Disease NA 0.129 0.01 35 0.203 Q8TAM1 L414S Disease NA 0.168 0.00 32 0.199 Q8TAM1 P363L Disease NA 0.028 0.06 2 0.045 Q8TAM1 P539L Polymorphism NA 0.348 1.00 -13 0.109 Q8TAM1 S311A Disease NA 0.158 0.10 46 0.212 Q8TAM1 S329L Disease NA 0.383 0.66 29 0.522 Q8TAM1 T689P Disease NA 0.500 0.00 56 0.707 Q8TAM1 V240G Disease NA 0.547 0.00 52 0.704 Q8TAM1 Y197C Disease NA 0.374 0.12 47 0.352 Q8TAM1 Y613C Disease NA 0.754 0.00 45 0.787 Q8TAM1 Y613H Disease NA 0.587 0.00 47 0.717 Q8TAP9 M144V Disease 0.125 0.190 NA 39 0.293 Q8TAS1 Y197D Polymorphism 0.569 0.883 0.00 72 0.927 Q8TAT2 A107T Polymorphism 0.281 0.080 0.55 30 0.044 Q8TAT2 E206V Polymorphism 0.104 0.032 0.25 21 0.029 Q8TAT5 R38C Polymorphism NA 0.115 0.18 45 0.119 Q8TAT5 A547S Polymorphism NA 0.538 0.11 42 0.541 Q8TAT5 H286R Polymorphism 0.198 0.033 0.18 24 0.055 Q8TAT5 H556R Polymorphism NA 0.434 0.00 63 0.347 Q8TAT5 P117R Polymorphism 0.698 0.369 0.10 39 0.487 Q8TAW3 A149V Polymorphism 0.062 0.222 0.28 22 0.158 Q8TAW3 P237S Polymorphism 0.124 0.535 0.10 -55 0.104 Q8TAX9 P306S Polymorphism 0.064 0.176 0.20 38 0.134 Q8TAX9 R325C Polymorphism 0.761 0.160 0.13 24 0.211 Q8TAZ6 I122T Polymorphism NA 0.199 0.10 22 0.102 Q8TB03 T176A Polymorphism NA 0.056 NA -24 0.044 Q8TB22 Q88E Polymorphism 0.272 0.307 0.56 -47 0.181 Q8TB22 S483T Polymorphism 0.173 0.299 0.58 -38 0.183 Q8TB24 H215L Polymorphism 0.214 0.221 1.00 47 0.212 Q8TB24 H215R Polymorphism 0.119 0.136 0.54 22 0.119 Q8TB24 T425I Polymorphism 0.390 0.080 0.18 0 0.067 Q8TB36 R120Q Disease 0.094 0.283 0.13 50 0.174 Q8TB36 R161H Disease NA 0.372 0.22 42 0.479 Q8TB36 R282C Disease 0.904 0.885 0.02 24 0.899 Q8TB36 R310Q Disease NA 0.398 0.04 3 0.393 Q8TB37 N198T Polymorphism 0.196 0.268 0.46 -8 0.153 Q8TB45 N204S Polymorphism 0.090 0.127 0.56 19 0.176 Q8TB45 S389N Polymorphism 0.060 0.312 0.24 -21 0.258 Q8TB61 L342V Polymorphism 0.085 0.198 0.42 -14 0.166 Q8TB69 G89S Polymorphism 0.291 0.187 0.72 -15 0.194 Q8TB72 N367S Polymorphism NA 0.218 0.12 -12 0.100 Q8TBA6 A67G Polymorphism 0.571 0.123 0.00 27 0.216 Q8TBA6 M486V Polymorphism 0.259 0.047 0.27 12 0.114 Q8TBB5 L155V Polymorphism 0.489 0.558 0.40 -18 0.419 Q8TBB6 G330R Polymorphism 0.877 0.919 0.13 71 0.873 Q8TBC3 Q507L Polymorphism 0.157 0.617 0.00 30 0.431 Q8TBC4 K9R Polymorphism 0.044 0.249 0.00 11 0.200 Q8TBE0 E26G Polymorphism NA 0.102 NA 29 0.047 Q8TBE0 D182H Polymorphism NA 0.141 NA 15 0.101 Q8TBE0 Q298K Polymorphism NA 0.043 NA 17 0.026 Q8TBE3 P166A Polymorphism NA 0.105 NA 21 0.084 Q8TBE3 V138I Polymorphism NA 0.076 NA -24 0.013 Q8TBF5 P155L Polymorphism NA 0.689 0.00 46 0.763 Q8TBG4 S185P Polymorphism NA 0.500 0.22 9 0.360 Q8TBN0 Q49R Polymorphism 0.203 0.068 0.40 3 0.062 Q8TBP6 T123I Polymorphism 0.514 0.203 0.38 20 0.481 Q8TBX8 V84A Polymorphism 0.209 0.535 0.07 39 0.526 Q8TBY8 A172T Polymorphism NA 0.041 0.36 1 0.035 Q8TBZ0 L299M Polymorphism NA 0.026 0.52 -43 0.006 Q8TBZ0 L382M Polymorphism NA 0.196 0.16 -17 0.188 Q8TBZ0 S409F Polymorphism NA 0.023 0.54 29 0.027 Q8TBZ2 R688W Polymorphism NA 0.280 NA 46 0.136 Q8TBZ2 S910R Polymorphism NA 0.056 NA -3 0.024 Q8TBZ3 G444C Polymorphism 0.394 0.115 0.02 36 0.251 Q8TBZ5 E243A Polymorphism 0.164 0.414 0.06 42 0.413 Q8TBZ9 D48H Polymorphism NA 0.042 NA -16 0.019 Q8TBZ9 E221A Polymorphism NA 0.073 NA 15 0.103 Q8TBZ9 E221K Polymorphism NA 0.168 NA 27 0.107 Q8TC20 E282A Polymorphism NA 0.089 0.30 37 0.091 Q8TC21 T136K Polymorphism 0.331 0.220 0.35 -32 0.061 Q8TC21 V476G Polymorphism 0.397 0.181 0.06 9 0.247 Q8TC27 Q98R Polymorphism 0.637 0.731 0.33 33 0.669 Q8TC27 K658N Polymorphism 0.178 0.139 0.12 11 0.162 Q8TC27 L327V Polymorphism 0.260 0.905 0.17 37 0.490 Q8TC57 T195P Polymorphism NA 0.036 NA -27 0.020 Q8TC71 K483R Polymorphism 0.212 0.613 0.00 29 0.709 Q8TC71 S227P Polymorphism 0.061 0.135 0.08 41 0.125 Q8TC84 P12L Polymorphism NA 0.231 0.00 0 0.434 Q8TC84 R46S Polymorphism NA 0.153 0.01 32 0.153 Q8TC84 L329V Polymorphism 0.238 0.561 0.34 35 0.425 Q8TC90 I379M Polymorphism NA 0.059 1.00 -36 0.027 Q8TC92 E16D Polymorphism NA 0.106 NA 13 0.081 Q8TC99 A127T Polymorphism NA 0.048 0.26 35 0.047 Q8TCB6 S9N Polymorphism 0.147 0.652 0.44 27 0.329 Q8TCB6 S10N Polymorphism NA 0.654 0.32 -9 0.443 Q8TCC7 A389V Polymorphism 0.078 0.583 0.27 -3 0.017 Q8TCC7 F129L Polymorphism 0.336 0.849 0.18 11 0.521 Q8TCC7 I260R Polymorphism 0.707 0.475 0.01 45 0.580 Q8TCC7 R149S Polymorphism 0.561 0.844 0.00 61 0.911 Q8TCC7 R277W Polymorphism 0.689 0.832 0.06 31 0.755 Q8TCC7 V281A Polymorphism 0.094 0.341 0.79 -21 0.020 Q8TCD1 P37H Polymorphism NA 0.262 0.00 33 0.401 Q8TCD5 P68L Polymorphism NA 0.286 0.01 30 0.420 Q8TCE9 C67R Polymorphism 0.859 0.203 0.86 23 0.114 Q8TCG1 I759V Polymorphism 0.130 0.070 0.18 7 0.044 Q8TCG1 K126R Polymorphism 0.063 0.039 1.00 -38 0.040 Q8TCG1 P494L Polymorphism 0.382 0.428 0.01 12 0.465 Q8TCG1 R229Q Polymorphism 0.454 0.241 0.00 41 0.260 Q8TCG1 S572A Polymorphism 0.144 0.069 0.42 1 0.041 Q8TCG1 T447A Polymorphism 0.157 0.082 0.01 14 0.100 Q8TCG2 S78P Polymorphism NA 0.039 0.31 -2 0.055 Q8TCI5 K97N Polymorphism NA 0.119 NA 3 0.126 Q8TCI5 H105N Polymorphism NA 0.280 NA 32 0.392 Q8TCS8 E230Q Polymorphism 0.827 0.884 0.00 47 0.908 Q8TCT0 L306F Polymorphism 0.479 0.630 0.11 -38 0.481 Q8TCT0 T211M Polymorphism 0.227 0.195 0.07 8 0.249 Q8TCT7 S574P Polymorphism 0.359 0.095 0.12 -42 0.055 Q8TCT9 A259P Polymorphism 0.696 0.733 0.02 32 0.870 Q8TCU3 E470K Polymorphism 0.246 0.420 0.07 8 0.293 Q8TCU3 M452T Polymorphism 0.282 0.178 0.03 3 0.241 Q8TCU3 R380K Polymorphism 0.060 0.561 0.30 12 0.039 Q8TCU3 V249M Polymorphism 0.149 0.840 0.12 43 0.747 Q8TCU4 V671G Polymorphism NA 0.208 0.58 -15 0.038 Q8TCU4 G1412A Polymorphism NA 0.093 0.24 31 0.083 Q8TCU4 S2111R Polymorphism NA 0.060 0.01 24 0.052 Q8TCU5 D835N Polymorphism 0.105 0.763 0.77 44 0.223 Q8TCU5 V362M Polymorphism 0.134 0.145 0.19 19 0.213 Q8TCU5 R1041Q Polymorphism NA 0.139 0.41 32 0.103 Q8TCU6 R696C Polymorphism 0.859 0.339 0.00 54 0.634 Q8TCU6 K1340E Polymorphism 0.240 0.185 1.00 12 0.051 Q8TCW7 I12F Polymorphism 0.425 0.147 0.00 -20 0.152 Q8TCX1 P58S Polymorphism 0.224 0.201 0.59 -5 0.184 Q8TCX1 I230L Polymorphism 0.104 0.080 0.59 -14 0.068 Q8TCY9 L756F Polymorphism 0.439 0.758 0.03 36 0.663 Q8TCY9 M779L Polymorphism 0.066 0.244 0.63 -7 0.220 Q8TD07 Y82N Polymorphism NA 0.270 1.00 3 0.088 Q8TD07 A141T Polymorphism 0.133 0.108 0.13 21 0.100 Q8TD07 T142I Polymorphism 0.283 0.198 0.37 4 0.071 Q8TD10 Q141L Polymorphism 0.229 0.036 NA -18 0.063 Q8TD17 S294L Polymorphism NA 0.384 0.54 27 0.400 Q8TD19 P828T Polymorphism 0.510 0.143 0.00 13 0.241 Q8TD19 R429H Polymorphism 0.246 0.211 0.05 -28 0.150 Q8TD23 V197A Polymorphism 0.301 0.371 0.02 21 0.483 Q8TD26 Q780H Polymorphism 0.736 0.293 0.02 11 0.570 Q8TD31 A367T Polymorphism 0.334 0.103 0.46 -1 0.110 Q8TD31 G575C Polymorphism 0.162 0.082 0.06 -11 0.059 Q8TD31 K546R Polymorphism 0.151 0.019 0.50 1 0.046 Q8TD31 R627Q Polymorphism 0.406 0.401 0.44 36 0.341 Q8TD31 S776C Polymorphism 0.154 0.030 0.03 -27 0.034 Q8TD35 G9W Polymorphism NA 0.100 NA 33 0.074 Q8TD46 R89K Polymorphism 0.121 0.153 1.00 -10 0.108 Q8TD46 E312Q Polymorphism NA 0.018 0.27 -30 0.003 Q8TD57 R545W Polymorphism NA 0.328 0.02 23 0.212 Q8TD57 E3457K Polymorphism 0.156 0.349 0.82 -22 0.227 Q8TD57 R3645C Polymorphism 0.787 0.947 0.00 43 0.882 Q8TD57 R3744W Polymorphism 0.905 0.833 0.00 50 0.926 Q8TD57 V1583I Polymorphism 0.099 0.138 0.81 -15 0.129 Q8TD86 W60R Polymorphism 0.588 0.597 0.07 -25 0.217 Q8TD90 G291C Polymorphism 0.453 0.465 0.01 12 0.553 Q8TD91 A328T Polymorphism NA 0.132 0.10 -4 0.133 Q8TD91 L165M Polymorphism NA 0.056 0.11 -1 0.068 Q8TD91 S155P Polymorphism NA 0.142 0.30 22 0.115 Q8TD94 A173P Polymorphism 0.167 0.474 0.01 -15 0.277 Q8TDB6 K668M Polymorphism 0.422 0.200 0.00 24 0.409 Q8TDC0 T209N Polymorphism 0.108 0.486 0.20 28 0.292 Q8TDD1 R693Q Polymorphism NA 0.350 0.27 26 0.321 Q8TDE3 P10S Polymorphism 0.116 0.232 0.39 5 0.172 Q8TDF5 A487G Polymorphism 0.043 0.157 0.33 27 0.125 Q8TDF6 E620K Polymorphism 0.291 0.335 0.24 45 0.180 Q8TDF6 Q120L Polymorphism 0.082 0.655 0.03 27 0.381 Q8TDF6 R261C Polymorphism 0.136 0.819 0.03 38 0.287 Q8TDG4 L235P Polymorphism NA 0.257 0.01 23 0.258 Q8TDI0 S1253I Polymorphism 0.473 0.339 0.08 33 0.464 Q8TDI0 S1539P Polymorphism 0.092 0.167 0.20 -21 0.087 Q8TDI7 E800Q Polymorphism 0.162 0.453 0.04 5 0.270 Q8TDI7 E816Q Polymorphism 0.155 0.148 0.58 -31 0.101 Q8TDI7 Q205R Polymorphism 0.087 0.111 0.70 2 0.075 Q8TDI7 W217R Polymorphism 0.809 0.837 0.00 54 0.884 Q8TDI8 E81K Polymorphism 0.241 0.271 0.87 36 0.308 Q8TDI8 D572N Disease 0.616 0.735 0.48 5 0.491 Q8TDI8 M486T Polymorphism 0.166 0.141 0.60 9 0.084 Q8TDI8 M654V Disease 0.114 0.232 0.81 -40 0.115 Q8TDL5 I84V Polymorphism 0.183 0.470 0.10 47 0.314 Q8TDL5 S298P Polymorphism 0.109 0.122 0.33 7 0.032 Q8TDL5 S313I Polymorphism 0.201 0.065 0.30 0 0.020 Q8TDL5 S479T Polymorphism NA 0.053 NA 18 0.045 Q8TDL5 T140A Polymorphism 0.167 0.059 0.71 33 0.048 Q8TDL5 T464S Polymorphism 0.113 0.090 0.21 -15 0.047 Q8TDL5 V284M Polymorphism 0.603 0.220 0.12 45 0.341 Q8TDM0 E56D Polymorphism 0.250 0.118 0.64 -8 0.094 Q8TDM6 Q140R Polymorphism NA 0.061 0.00 21 0.067 Q8TDM6 P1481Q Polymorphism NA 0.346 0.19 44 0.516 Q8TDN1 G8W Polymorphism NA 0.118 NA 33 0.089 Q8TDN1 R206W Polymorphism 0.874 0.615 0.00 24 0.841 Q8TDN2 A259V Disease 0.663 0.705 0.01 49 0.855 Q8TDN2 G459D Disease 0.998 0.914 0.00 77 0.954 Q8TDN2 L126Q Disease NA 0.685 0.00 40 0.795 Q8TDN2 S256W Disease 0.947 0.831 0.00 48 0.912 Q8TDN2 W188C Disease 0.996 0.879 0.00 70 0.949 Q8TDP1 R69W Disease 0.687 0.477 0.02 47 0.708 Q8TDP1 K143I Disease 0.581 0.095 0.18 13 0.113 Q8TDQ7 P182S Polymorphism 0.582 0.860 0.00 52 0.893 Q8TDR0 M620L Polymorphism NA 0.147 1.00 -34 0.084 Q8TDR0 N228S Polymorphism NA 0.071 0.65 -20 0.016 Q8TDR4 R194H Polymorphism 0.580 0.084 0.00 14 0.110 Q8TDS4 F198L Polymorphism 0.100 0.135 1.00 4 0.101 Q8TDS4 Q187R Polymorphism 0.095 0.475 0.54 40 0.092 Q8TDU9 L329S Polymorphism NA 0.173 0.43 -7 0.159 Q8TDV0 A144V Polymorphism 0.408 0.115 0.22 37 0.234 Q8TDW0 M800I Polymorphism NA 0.152 0.03 -2 0.085 Q8TDW4 R451Q Polymorphism 0.261 0.500 0.17 -1 0.385 Q8TDW7 S412F Polymorphism NA 0.297 0.18 48 0.450 Q8TDW7 I2755V Polymorphism NA 0.269 0.78 -34 0.176 Q8TDW7 N2293S Polymorphism NA 0.457 0.84 37 0.213 Q8TDW7 Q1726R Polymorphism NA 0.144 0.68 55 0.222 Q8TDW7 S3812G Polymorphism NA 0.315 0.71 0 0.234 Q8TDW7 V1167G Polymorphism 0.893 0.190 0.00 47 0.673 Q8TDW7 V2622F Polymorphism NA 0.457 0.02 19 0.372 Q8TDX7 R35G Polymorphism 0.633 0.562 0.23 22 0.748 Q8TDX9 D812N Polymorphism 0.096 0.110 0.11 -18 0.082 Q8TDX9 T879A Polymorphism 0.216 0.071 0.02 -23 0.029 Q8TDX9 K1272E Polymorphism 0.229 0.081 NA 24 0.060 Q8TDY2 M234T Polymorphism NA 0.034 NA 5 0.044 Q8TDY2 N1314K Polymorphism 0.196 0.085 0.08 19 0.079 Q8TDY2 R1216K Polymorphism 0.087 0.012 0.24 -26 0.011 Q8TDY2 S1424F Polymorphism 0.545 0.106 0.00 29 0.211 Q8TDY3 G247R Polymorphism 0.777 0.891 0.00 52 0.781 Q8TDY4 E377A Polymorphism NA 0.379 0.04 39 0.432 Q8TDY8 N301S Polymorphism 0.127 0.743 0.32 13 0.269 Q8TDY8 C1125Y Polymorphism 0.656 0.549 NA 6 0.701 Q8TDY8 T1102A Polymorphism 0.223 0.191 NA -1 0.114 Q8TDZ2 A12T Polymorphism 0.123 0.083 0.31 -29 0.081 Q8TE02 E14K Polymorphism NA 0.294 NA 33 0.127 Q8TE02 D303Y Polymorphism NA 0.411 NA 40 0.091 Q8TE23 S9C Polymorphism NA 0.070 1.00 -67 0.029 Q8TE23 A574T Polymorphism 0.310 0.389 0.48 -17 0.214 Q8TE23 R838K Polymorphism 0.054 0.113 0.52 -33 0.075 Q8TE54 I215V Polymorphism 0.129 0.060 1.00 -22 0.038 Q8TE57 A486T Polymorphism 0.305 0.283 0.12 21 0.335 Q8TE57 E863K Polymorphism 0.120 0.384 0.76 8 0.234 Q8TE57 M110V Polymorphism NA 0.255 0.12 -53 0.173 Q8TE57 R789C Polymorphism 0.847 0.847 0.01 39 0.873 Q8TE60 L769I Polymorphism 0.048 0.254 0.19 -21 0.172 Q8TE67 G163S Polymorphism 0.070 0.171 0.99 -38 0.092 Q8TE67 H293Y Polymorphism 0.076 0.155 1.00 -26 0.078 Q8TE67 R581Q Polymorphism 0.311 0.020 1.00 39 0.071 Q8TE73 H12Q Polymorphism NA 0.040 NA 15 0.010 Q8TE73 K765N Polymorphism NA 0.287 0.48 1 0.254 Q8TE73 L591R Polymorphism NA 0.500 0.27 -26 0.352 Q8TE73 Q620K Polymorphism NA 0.259 0.50 -16 0.356 Q8TE73 E2347K Disease 0.996 0.856 0.00 67 0.934 Q8TE73 F2843S Disease 0.215 0.731 0.03 40 0.598 Q8TE73 G3519R Disease 0.993 0.872 0.00 77 0.930 Q8TE73 G4205V Disease 0.997 0.740 0.00 62 0.946 Q8TE73 I4450V Polymorphism 0.114 0.195 0.25 2 0.070 Q8TE73 Q2463R Polymorphism 0.212 0.445 0.42 9 0.197 Q8TE73 R1716L Disease NA 0.836 0.00 59 0.897 Q8TE73 R2425H Polymorphism 0.348 0.259 0.17 -28 0.317 Q8TE73 R2501P Disease 0.860 0.918 0.00 73 0.921 Q8TE73 S2264N Disease 0.512 0.524 0.04 56 0.758 Q8TE73 S3843L Disease 0.780 0.838 0.00 52 0.901 Q8TE73 T4220A Polymorphism 0.109 0.363 0.30 29 0.138 Q8TE73 W3409S Disease 0.887 0.939 0.01 64 0.919 Q8TE76 R653C Polymorphism 0.548 0.091 0.09 30 0.063 Q8TE77 E239V Polymorphism NA 0.222 0.01 30 0.364 Q8TE82 R785C Polymorphism 0.381 0.247 0.01 55 0.301 Q8TEA7 T425M Polymorphism NA 0.180 0.08 15 0.170 Q8TEB1 R207H Polymorphism 0.057 0.661 0.43 -5 0.033 Q8TEB9 A110T Polymorphism 0.246 0.198 0.35 -27 0.094 Q8TEC5 V687I Polymorphism 0.054 0.031 0.60 -51 0.033 Q8TED0 R332S Polymorphism 0.297 0.463 0.76 22 0.318 Q8TED0 T483P Polymorphism 0.506 0.739 0.04 53 0.791 Q8TEK3 L726M Polymorphism 0.331 0.052 NA 0 0.068 Q8TEK3 G1386S Polymorphism NA 0.120 NA 14 0.024 Q8TEM1 A297T Polymorphism 0.345 0.058 0.12 -40 0.096 Q8TEM1 P821A Polymorphism 0.186 0.031 0.64 24 0.118 Q8TEM1 R786L Polymorphism 0.511 0.137 0.79 -9 0.072 Q8TEM1 L1752S Polymorphism 0.256 0.125 0.03 -2 0.066 Q8TEM1 V1787M Polymorphism 0.170 0.068 0.20 7 0.026 Q8TEP8 S956P Polymorphism 0.100 0.084 NA -42 0.024 Q8TEP8 V769M Polymorphism 0.043 0.063 NA -10 0.039 Q8TEP8 K1675E Polymorphism 0.069 0.202 NA 16 0.139 Q8TEP8 L1105F Polymorphism 0.056 0.025 NA -32 0.019 Q8TEP8 R1853L Polymorphism 0.096 0.118 NA -6 0.038 Q8TEP8 S1455N Polymorphism 0.057 0.080 NA -19 0.068 Q8TEQ6 P1155S Polymorphism NA 0.108 NA -21 0.059 Q8TER0 A1362S Polymorphism 0.060 0.096 0.75 34 0.054 Q8TER0 L1228P Polymorphism NA 0.398 0.18 -3 0.386 Q8TER5 M1312T Polymorphism 0.160 0.352 0.63 24 0.160 Q8TES7 P371S Polymorphism NA 0.142 0.00 29 0.162 Q8TET4 I166V Polymorphism 0.032 0.152 1.00 -34 0.066 Q8TET4 Q848R Polymorphism 0.197 0.140 0.52 -12 0.125 Q8TEU7 A594P Polymorphism NA 0.552 0.02 55 0.703 Q8TEU7 S570A Polymorphism NA 0.101 1.00 -9 0.082 Q8TEV9 R556H Polymorphism NA 0.061 0.53 -15 0.027 Q8TEW0 D575N Polymorphism 0.249 0.513 0.26 32 0.365 Q8TEW8 Q295K Polymorphism 0.228 0.519 0.29 29 0.442 Q8TEW8 R192K Polymorphism 0.207 0.104 0.39 -9 0.058 Q8TEX9 A513V Polymorphism 0.197 0.196 0.24 -32 0.249 Q8TF05 E43K Polymorphism NA 0.205 0.00 53 0.427 Q8TF05 S593N Polymorphism 0.232 0.031 0.01 -20 0.030 Q8TF05 S595N Polymorphism 0.522 0.114 0.27 -6 0.150 Q8TF08 H27Q Polymorphism 0.672 0.235 0.00 56 0.617 Q8TF17 E657K Disease 0.667 0.798 0.00 56 0.765 Q8TF17 H696R Polymorphism 0.137 0.052 0.41 15 0.036 Q8TF17 R529Q Disease 0.706 0.682 0.00 56 0.880 Q8TF17 R658C Disease 0.925 0.633 0.00 58 0.918 Q8TF27 I82V Polymorphism NA 0.089 1.00 -33 0.063 Q8TF30 H736P Polymorphism 0.581 0.204 0.15 -20 0.168 Q8TF30 Q340K Polymorphism 0.175 0.164 0.03 -25 0.132 Q8TF30 R345Q Polymorphism 0.455 0.060 0.12 -18 0.103 Q8TF40 Q648R Polymorphism 0.173 0.023 0.75 -7 0.025 Q8TF42 A68T Polymorphism 0.300 0.142 0.05 29 0.274 Q8TF50 S511F Polymorphism 0.265 0.219 0.56 55 0.447 Q8TF62 V1190G Polymorphism NA 0.175 0.03 25 0.216 Q8TF71 K508Q Polymorphism 0.096 0.219 0.36 7 0.182 Q8TF76 G283S Polymorphism NA 0.034 0.00 -53 0.031 Q8TF76 R145H Polymorphism NA 0.102 0.00 3 0.057 Q8WTP8 P15L Polymorphism NA 0.152 0.00 26 0.166 Q8WTP8 S88C Polymorphism NA 0.248 0.05 14 0.371 Q8WTQ7 R81H Polymorphism NA 0.133 0.18 0 0.140 Q8WTQ7 C113W Polymorphism NA 0.564 0.17 56 0.743 Q8WTQ7 E309Q Polymorphism 0.156 0.130 0.64 -44 0.118 Q8WTQ7 P460T Polymorphism 0.111 0.080 0.46 -54 0.098 Q8WTQ7 R226W Polymorphism 0.982 0.576 0.00 33 0.831 Q8WTQ7 R461C Polymorphism 0.857 0.360 0.04 36 0.646 Q8WTR2 S216R Polymorphism NA 0.344 0.01 17 0.168 Q8WTR7 S74G Polymorphism 0.261 0.076 0.33 5 0.217 Q8WTR7 S662A Polymorphism 0.297 0.130 0.97 -23 0.109 Q8WTS1 E7K Disease NA 0.061 0.00 31 0.137 Q8WTS1 E260K Disease 0.572 0.862 0.56 42 0.798 Q8WTS1 Q130P Disease 0.637 0.475 0.20 46 0.674 Q8WTS1 S115G Disease 0.842 0.899 0.00 62 0.942 Q8WTT2 R504I Polymorphism 0.652 0.804 0.04 48 0.860 Q8WTT2 T655S Polymorphism NA 0.138 0.81 -16 0.129 Q8WTU0 G136S Polymorphism 0.169 0.038 0.57 -39 0.058 Q8WTU0 G239E Polymorphism 0.407 0.762 0.04 42 0.787 Q8WTU0 S142G Polymorphism 0.264 0.176 0.11 9 0.255 Q8WTV0 C511R Polymorphism NA 0.139 NA 45 0.081 Q8WTV0 G167S Polymorphism NA 0.589 0.09 -21 0.488 Q8WTW3 N392S Polymorphism NA 0.074 0.00 -21 0.097 Q8WU03 P82S Polymorphism 0.356 0.176 0.12 27 0.202 Q8WU03 L168I Polymorphism 0.368 0.636 0.06 51 0.674 Q8WU08 K58M Polymorphism 0.578 0.279 0.17 -1 0.574 Q8WU20 K303N Polymorphism 0.141 0.175 0.00 -27 0.086 Q8WU20 N449D Polymorphism 0.405 0.063 0.18 14 0.077 Q8WU67 R3C Polymorphism NA 0.375 0.00 24 0.247 Q8WU90 T408P Polymorphism 0.354 0.299 0.03 23 0.438 Q8WU90 V342E Polymorphism 0.511 0.676 0.01 14 0.681 Q8WUA8 D344E Polymorphism NA 0.062 1.00 -26 0.018 Q8WUD1 N212T Polymorphism NA 0.317 0.22 11 0.273 Q8WUF8 S131N Polymorphism 0.126 0.107 0.61 -28 0.072 Q8WUH2 H725R Polymorphism 0.063 0.166 0.70 0 0.062 Q8WUJ3 P1169A Polymorphism 0.397 0.054 0.39 -8 0.090 Q8WUJ3 V1109I Polymorphism 0.103 0.022 0.04 20 0.107 Q8WUM0 I294V Polymorphism 0.127 0.125 NA -12 0.101 Q8WUM0 Q406R Polymorphism 0.084 0.036 NA 18 0.036 Q8WUM4 A309T Polymorphism 0.119 0.217 0.56 -54 0.154 Q8WUM4 K638E Polymorphism 0.189 0.228 1.00 3 0.174 Q8WUM4 N550S Polymorphism 0.111 0.072 0.71 -44 0.112 Q8WUP2 R39C Polymorphism 0.443 0.165 0.03 33 0.208 Q8WUP2 S191F Polymorphism 0.097 0.373 0.69 27 0.164 Q8WUS8 K96E Polymorphism 0.248 0.378 0.20 12 0.152 Q8WUS8 S10T Polymorphism NA 0.138 0.58 -47 0.112 Q8WUT4 P138L Polymorphism 0.080 0.343 0.05 44 0.273 Q8WUT4 T141A Polymorphism 0.063 0.125 1.00 -44 0.059 Q8WUU5 G54S Polymorphism 0.105 0.134 0.62 -31 0.032 Q8WUX2 R82G Polymorphism 0.846 0.951 0.00 67 0.949 Q8WUY1 E93Q Polymorphism 0.100 0.284 0.36 -29 0.071 Q8WV16 W22C Polymorphism NA 0.583 NA 44 0.711 Q8WV16 L334F Polymorphism NA 0.094 0.16 1 0.091 Q8WV16 N266S Polymorphism NA 0.071 0.34 -15 0.054 Q8WV16 R439I Polymorphism NA 0.818 0.01 43 0.800 Q8WV19 I109V Polymorphism 0.306 0.095 NA -44 0.141 Q8WV22 N47S Polymorphism 0.173 0.163 0.43 23 0.180 Q8WV22 T38R Polymorphism 0.280 0.207 0.73 25 0.102 Q8WV35 R75Q Polymorphism 0.365 0.109 0.65 22 0.181 Q8WV44 A78T Polymorphism NA 0.209 0.55 10 0.213 Q8WV48 S190F Polymorphism NA 0.079 NA 4 0.034 Q8WV48 S242C Polymorphism NA 0.210 NA 21 0.156 Q8WVB6 Q82P Polymorphism NA 0.074 NA 0 0.046 Q8WVB6 S63F Polymorphism NA 0.344 NA -21 0.261 Q8WVD3 K81R Polymorphism 0.057 0.074 0.44 -23 0.059 Q8WVE0 T193N Polymorphism 0.151 0.338 0.52 -7 0.173 Q8WVE6 R86G Polymorphism NA 0.123 0.21 29 0.107 Q8WVF1 P31R Polymorphism 0.123 0.271 0.00 22 0.326 Q8WVK2 T81I Polymorphism NA 0.087 0.06 0 0.083 Q8WVR3 R295H Polymorphism NA 0.364 NA 32 0.237 Q8WVS4 E91G Polymorphism NA 0.209 NA 41 0.372 Q8WVS4 Q273R Polymorphism NA 0.027 NA -10 0.049 Q8WVT3 S301G Polymorphism 0.471 0.361 NA 27 0.529 Q8WVV4 E296A Polymorphism 0.187 0.067 0.16 33 0.043 Q8WVV4 M349L Polymorphism 0.096 0.018 1.00 -26 0.009 Q8WVV4 P207S Polymorphism 0.066 0.034 1.00 -33 0.026 Q8WVV4 Q434K Polymorphism 0.063 0.050 1.00 -14 0.040 Q8WVV4 R329Q Disease 0.349 0.336 0.05 28 0.189 Q8WVX3 P32H Polymorphism NA 0.113 0.08 44 0.118 Q8WVX9 E96K Polymorphism 0.158 0.465 0.33 25 0.264 Q8WW01 Q59H Polymorphism NA 0.742 NA 28 0.744 Q8WW14 T124M Polymorphism NA 0.228 NA 45 0.377 Q8WW18 D22E Polymorphism NA 0.061 NA -26 0.016 Q8WW24 T83M Polymorphism NA 0.110 0.12 4 0.171 Q8WW27 S75F Polymorphism NA 0.252 0.00 28 0.209 Q8WW27 F271S Polymorphism NA 0.058 0.08 24 0.023 Q8WW27 P275S Polymorphism NA 0.032 NA 14 0.043 Q8WW27 V345M Polymorphism NA 0.110 0.14 1 0.043 Q8WW38 E30G Disease 0.441 0.076 0.03 35 0.095 Q8WW38 A403G Polymorphism 0.207 0.033 0.12 -11 0.056 Q8WW38 E782D Polymorphism 0.319 0.049 0.02 -26 0.034 Q8WW38 S657G Disease 0.567 0.044 0.06 32 0.057 Q8WW38 A1055V Polymorphism NA 0.047 0.00 -19 0.088 Q8WW52 D51N Polymorphism 0.415 0.095 0.56 8 0.117 Q8WW52 A416V Polymorphism 0.116 0.057 0.31 2 0.042 Q8WW52 G526A Polymorphism 0.057 0.029 1.00 -45 0.014 Q8WW52 G546D Polymorphism 0.173 0.355 0.77 43 0.313 Q8WWA0 R313P Polymorphism NA 0.980 0.00 46 0.851 Q8WWA0 V109D Polymorphism NA 0.335 0.85 -12 0.050 Q8WWB7 I223V Polymorphism NA 0.044 1.00 -40 0.010 Q8WWF3 R88W Polymorphism NA 0.131 NA 59 0.042 Q8WWF5 V100I Polymorphism 0.412 0.071 0.52 9 0.085 Q8WWF5 V159A Polymorphism 0.270 0.231 1.00 1 0.264 Q8WWG9 G47S Polymorphism 0.453 0.866 0.11 13 0.787 Q8WWH5 R167K Polymorphism NA 0.163 0.46 -48 0.108 Q8WWI5 S644A Polymorphism 0.072 0.035 0.52 -36 0.042 Q8WWK9 M236K Polymorphism 0.130 0.105 0.96 22 0.081 Q8WWL7 G1001R Polymorphism NA 0.099 0.19 37 0.024 Q8WWN8 D218H Polymorphism NA 0.073 NA 35 0.062 Q8WWN9 S194P Polymorphism 0.473 0.137 0.14 -31 0.132 Q8WWP7 R254S Polymorphism 0.357 0.317 0.11 8 0.288 Q8WWQ0 T874I Polymorphism 0.220 0.095 0.04 -11 0.087 Q8WWQ0 L1093P Polymorphism 0.143 0.353 0.29 -41 0.042 Q8WWQ0 N1445T Polymorphism 0.372 0.089 0.16 -2 0.171 Q8WWQ0 T1135P Polymorphism 0.474 0.296 0.01 -60 0.382 Q8WWQ2 A315T Polymorphism 0.300 0.159 0.51 -19 0.217 Q8WWQ2 Y579F Polymorphism 0.048 0.324 0.89 -17 0.182 Q8WWQ8 E306K Polymorphism NA 0.637 0.92 55 0.535 Q8WWQ8 I110V Polymorphism 0.111 0.129 0.52 -15 0.141 Q8WWQ8 R787Q Polymorphism NA 0.574 0.74 0 0.328 Q8WWQ8 R881H Polymorphism 0.326 0.172 0.15 38 0.308 Q8WWQ8 N1736T Polymorphism NA 0.066 0.56 28 0.078 Q8WWQ8 Y2519S Polymorphism NA 0.152 0.01 37 0.192 Q8WWU5 G253A Polymorphism 0.185 0.111 0.46 -31 0.110 Q8WWU7 Q171R Polymorphism NA 0.279 0.53 0 0.214 Q8WWU7 R103H Polymorphism NA 0.257 0.00 -22 0.100 Q8WWX8 F258L Polymorphism 0.355 0.671 0.62 11 0.439 Q8WWY3 A194E Disease 0.589 0.613 0.03 30 0.759 Q8WWY3 A216P Disease 0.865 0.963 0.00 52 0.931 Q8WWY8 W108R Disease 0.947 0.947 0.00 73 0.942 Q8WWZ1 A51D Polymorphism 0.059 0.237 0.68 -2 0.033 Q8WWZ3 E152K Disease NA 0.435 NA 45 0.599 Q8WWZ3 L122R Disease NA 0.723 NA 51 0.809 Q8WWZ3 S103F Polymorphism NA 0.135 NA 29 0.134 Q8WWZ4 P203S Polymorphism 0.093 0.380 0.82 -38 0.162 Q8WWZ4 R1322W Polymorphism 0.970 0.783 0.00 1 0.877 Q8WWZ7 Q93K Polymorphism 0.213 0.136 0.60 -11 0.123 Q8WWZ7 M753V Polymorphism 0.192 0.095 0.40 9 0.147 Q8WWZ7 M960V Polymorphism 0.100 0.148 0.99 -7 0.085 Q8WWZ7 D1260G Polymorphism 0.159 0.241 0.22 3 0.273 Q8WWZ8 S237P Polymorphism 0.376 0.500 0.10 10 0.640 Q8WX39 C90F Polymorphism 0.750 0.440 0.42 27 0.586 Q8WX94 C761Y Disease 0.978 0.769 0.02 46 0.895 Q8WX94 G487E Polymorphism NA 0.337 1.00 -6 0.266 Q8WX94 L398R Disease 0.711 0.795 0.03 58 0.907 Q8WX94 N913S Disease 0.865 0.755 0.54 68 0.893 Q8WX94 P651S Disease 0.090 0.171 0.75 30 0.154 Q8WX94 P716A Disease 0.544 0.041 0.57 29 0.183 Q8WX94 R693P Disease 0.476 0.743 0.11 69 0.874 Q8WX94 R693Q Disease 0.242 0.438 0.30 47 0.371 Q8WX94 R693W Disease 0.788 0.494 0.02 56 0.887 Q8WX94 R721W Disease 0.788 0.302 0.01 14 0.623 Q8WX94 T971A Polymorphism NA 0.112 NA 31 0.116 Q8WX94 V319I Polymorphism 0.090 0.152 1.00 0 0.112 Q8WXA2 V46I Polymorphism NA 0.186 0.69 19 0.061 Q8WXA8 G405A Polymorphism 0.163 0.181 1.00 0 0.124 Q8WXA8 N163K Polymorphism 0.049 0.092 0.27 1 0.100 Q8WXB1 T192I Polymorphism 0.239 0.249 0.09 -3 0.274 Q8WXB4 S141G Polymorphism 0.320 0.318 0.43 19 0.305 Q8WXC7 K342M Polymorphism NA 0.052 NA 21 0.042 Q8WXC7 S380A Polymorphism NA 0.104 NA 18 0.049 Q8WXD0 I604V Polymorphism NA 0.294 0.63 26 0.371 Q8WXD0 T222P Disease 0.344 0.394 0.21 13 0.345 Q8WXD2 M233V Polymorphism 0.118 0.028 0.80 -40 0.017 Q8WXD2 S125N Polymorphism 0.151 0.144 0.39 0 0.050 Q8WXD5 G140D Polymorphism NA 0.267 NA -4 0.193 Q8WXE9 R646H Polymorphism 0.146 0.190 0.36 10 0.137 Q8WXE9 S307P Polymorphism NA 0.039 0.02 0 0.049 Q8WXE9 S851A Polymorphism 0.291 0.247 0.20 2 0.274 Q8WXF7 A161P Disease 0.547 0.862 0.03 64 0.906 Q8WXF7 F193C Polymorphism 0.849 0.770 0.01 51 0.915 Q8WXF7 H247P Disease 0.224 0.869 0.23 23 0.471 Q8WXF7 H258R Disease 0.096 0.117 0.62 -8 0.106 Q8WXF7 R217Q Disease 0.607 0.909 0.00 67 0.894 Q8WXF7 R239C Disease 0.678 0.624 0.06 26 0.774 Q8WXF7 S259Y Disease 0.621 0.544 0.13 27 0.605 Q8WXG6 R765Q Polymorphism 0.077 0.053 0.83 -11 0.059 Q8WXG6 L1040F Polymorphism 0.344 0.297 0.01 33 0.308 Q8WXG9 L127R Polymorphism NA 0.660 0.00 0 0.496 Q8WXG9 V551A Polymorphism NA 0.600 0.04 0 0.511 Q8WXG9 A2803T Polymorphism NA 0.322 0.18 0 0.252 Q8WXG9 E3471K Polymorphism NA 0.077 NA 0 0.024 Q8WXG9 E5344G Polymorphism NA 0.089 0.10 0 0.059 Q8WXG9 F3347L Polymorphism NA 0.084 0.91 0 0.064 Q8WXG9 G2379A Polymorphism NA 0.577 0.00 0 0.467 Q8WXG9 I1187V Polymorphism NA 0.165 0.08 0 0.169 Q8WXG9 L1093F Polymorphism NA 0.433 0.77 0 0.247 Q8WXG9 L2004F Polymorphism NA 0.308 0.04 0 0.379 Q8WXG9 N2345S Polymorphism NA 0.693 0.04 0 0.502 Q8WXG9 N2584S Polymorphism NA 0.082 0.88 0 0.078 Q8WXG9 P1987L Polymorphism NA 0.169 0.02 0 0.236 Q8WXG9 R2097C Polymorphism NA 0.700 0.04 0 0.518 Q8WXG9 S2764L Polymorphism NA 0.477 0.36 0 0.477 Q8WXG9 T1927M Polymorphism NA 0.445 0.01 0 0.341 Q8WXG9 V3094I Polymorphism NA 0.235 0.20 0 0.242 Q8WXH0 P8S Polymorphism 0.042 0.125 NA 0 0.104 Q8WXH0 I574T Polymorphism NA 0.293 0.03 0 0.257 Q8WXH0 A2284V Polymorphism NA 0.160 0.25 0 0.134 Q8WXH0 A2394T Polymorphism NA 0.107 0.17 0 0.057 Q8WXH0 A2395T Polymorphism NA 0.105 0.26 0 0.052 Q8WXH0 A6155V Polymorphism 0.532 0.126 0.11 0 0.198 Q8WXH0 D5547N Polymorphism 0.326 0.117 0.22 0 0.228 Q8WXH0 G2801S Polymorphism NA 0.086 0.52 0 0.052 Q8WXH0 H3309R Polymorphism NA 0.113 0.22 0 0.094 Q8WXH0 K6681E Polymorphism 0.138 0.156 1.00 0 0.082 Q8WXH0 N2358S Polymorphism NA 0.063 0.36 0 0.075 Q8WXH0 N3982H Polymorphism NA 0.107 0.13 0 0.098 Q8WXH0 P4912A Polymorphism NA 0.111 0.49 0 0.193 Q8WXH0 R1393W Polymorphism 0.639 0.171 0.04 0 0.253 Q8WXH0 R6697W Polymorphism 0.744 0.178 0.03 0 0.443 Q8WXH0 S2802G Polymorphism NA 0.116 0.11 0 0.125 Q8WXH0 V2490G Polymorphism NA 0.143 0.30 0 0.074 Q8WXH2 P645L Polymorphism 0.114 0.200 0.00 3 0.116 Q8WXH4 D249N Polymorphism 0.194 0.226 0.27 -16 0.198 Q8WXI3 R453C Polymorphism NA 0.234 0.10 12 0.306 Q8WXI4 R11W Polymorphism 0.586 0.290 NA 33 0.313 Q8WXI4 G202D Polymorphism 0.289 0.160 0.81 -16 0.103 Q8WXI4 M212I Polymorphism 0.269 0.088 0.17 36 0.161 Q8WXI4 P165L Polymorphism 0.186 0.608 1.00 3 0.415 Q8WXI4 R536H Polymorphism NA 0.145 0.02 39 0.166 Q8WXI7 A2747T Polymorphism NA 0.236 0.05 0 0.227 Q8WXI7 H5743D Polymorphism NA 0.064 0.13 0 0.035 Q8WXI7 I2150V Polymorphism NA 0.036 0.06 0 0.027 Q8WXI7 L1833F Polymorphism NA 0.067 0.02 0 0.107 Q8WXI7 M2786I Polymorphism NA 0.165 0.08 0 0.055 Q8WXI7 R1015G Polymorphism NA 0.324 0.27 0 0.067 Q8WXI7 S1953P Polymorphism NA 0.205 0.01 0 0.056 Q8WXI7 S2058P Polymorphism NA 0.157 0.00 0 0.174 Q8WXI7 T2271A Polymorphism NA 0.113 0.03 0 0.030 Q8WXI7 T2834M Polymorphism NA 0.044 0.02 0 0.039 Q8WXI7 T7065A Polymorphism NA 0.086 0.03 0 0.109 Q8WXI7 V2288L Polymorphism NA 0.146 0.14 0 0.061 Q8WXJ9 S2N Polymorphism 0.058 0.047 NA 27 0.043 Q8WXQ8 L336S Polymorphism 0.069 0.741 0.57 -19 0.144 Q8WXQ8 S378G Polymorphism 0.285 0.847 0.04 18 0.536 Q8WXR4 P21S Polymorphism NA 0.410 0.00 9 0.481 Q8WXR4 A406T Polymorphism 0.098 0.260 0.58 -31 0.139 Q8WXR4 E773G Polymorphism 0.235 0.336 0.09 4 0.314 Q8WXR4 H316L Polymorphism NA 0.087 0.69 21 0.159 Q8WXR4 K309E Polymorphism NA 0.261 1.00 -21 0.200 Q8WXR4 N267S Polymorphism NA 0.392 0.00 10 0.296 Q8WXR4 N388S Polymorphism 0.106 0.091 0.73 -36 0.141 Q8WXR4 Q638P Polymorphism 0.264 0.836 0.27 25 0.497 Q8WXR4 R185H Polymorphism NA 0.514 0.12 28 0.607 Q8WXR4 R918Q Polymorphism NA 0.566 0.60 37 0.519 Q8WXR4 R1165C Polymorphism NA 0.192 0.10 41 0.186 Q8WXR4 V1137I Polymorphism NA 0.060 0.55 7 0.062 Q8WXS3 S164T Polymorphism 0.150 0.054 0.23 14 0.039 Q8WXS8 L937M Polymorphism 0.327 0.230 0.07 6 0.332 Q8WXS8 S1017N Polymorphism 0.355 0.073 0.52 32 0.151 Q8WXU2 P2S Polymorphism NA 0.510 0.00 15 0.732 Q8WXU2 N38K Polymorphism NA 0.153 0.00 16 0.219 Q8WXU2 E191G Polymorphism NA 0.065 0.01 37 0.134 Q8WXW3 R405Q Polymorphism 0.434 0.464 0.28 35 0.550 Q8WXX0 A280T Polymorphism NA 0.169 0.52 -30 0.125 Q8WXX0 H169P Polymorphism NA 0.301 0.29 37 0.492 Q8WXX0 I315V Polymorphism NA 0.099 0.84 -32 0.096 Q8WXX0 K825E Polymorphism NA 0.286 1.00 -41 0.239 Q8WXX0 R545C Polymorphism NA 0.855 0.07 24 0.663 Q8WXX0 S438N Polymorphism NA 0.296 0.53 -44 0.223 Q8WXX0 M2020T Polymorphism 0.523 0.425 0.08 30 0.658 Q8WXX0 N2459K Polymorphism 0.259 0.417 0.93 -14 0.265 Q8WXX0 R3386H Polymorphism 0.865 0.763 0.01 61 0.926 Q8WXX0 T2569I Polymorphism 0.379 0.290 0.52 13 0.330 Q8WXX7 A303S Polymorphism NA 0.071 0.72 -34 0.026 Q8WY07 L508V Polymorphism 0.168 0.070 0.44 -33 0.110 Q8WY91 S121G Polymorphism NA 0.046 1.00 -25 0.023 Q8WYB5 V1499I Polymorphism NA 0.097 0.19 -8 0.085 Q8WYJ6 G80V Polymorphism 0.922 0.869 0.00 41 0.885 Q8WYK0 A403T Polymorphism NA 0.148 0.29 -6 0.126 Q8WYK0 V230I Polymorphism 0.190 0.437 0.33 1 0.262 Q8WYK1 S452L Polymorphism 0.626 0.743 0.23 20 0.686 Q8WYP3 A643T Polymorphism 0.133 0.143 0.45 -42 0.103 Q8WYQ5 I174V Polymorphism 0.123 0.133 NA -50 0.025 Q8WYQ5 N725D Polymorphism 0.259 0.317 NA 32 0.434 Q8WYQ9 G244A Polymorphism NA 0.078 0.76 29 0.052 Q8WYQ9 V693M Polymorphism NA 0.211 0.07 18 0.268 Q8WZ04 L16P Disease NA 0.293 NA 24 0.136 Q8WZ04 R81Q Disease 0.487 0.426 0.36 42 0.349 Q8WZ04 E110K Disease 0.440 0.545 0.30 26 0.469 Q8WZ04 R158H Disease 0.590 0.809 0.08 11 0.570 Q8WZ04 R208Q Disease 0.281 0.048 0.32 -22 0.084 Q8WZ04 W105R Disease 0.672 0.473 0.35 44 0.648 Q8WZ42 D60Y Polymorphism 0.734 0.775 NA 0 0.853 Q8WZ42 V54M Disease 0.376 0.673 NA 0 0.441 Q8WZ42 A743V Disease NA 0.203 NA 0 0.328 Q8WZ42 R279W Disease NA 0.376 NA 0 0.499 Q8WZ42 R328C Polymorphism NA 0.383 NA 0 0.499 Q8WZ42 R740L Disease NA 0.201 NA 0 0.328 Q8WZ42 R922H Polymorphism NA 0.414 NA 0 0.499 Q8WZ42 T811I Polymorphism NA 0.165 NA 0 0.158 Q8WZ42 V498I Polymorphism NA 0.144 NA 0 0.137 Q8WZ42 W976R Disease NA 0.842 NA 0 0.722 Q8WZ42 A1081T Polymorphism NA 0.192 NA 0 0.355 Q8WZ42 A2164T Polymorphism 0.405 0.706 NA 0 0.454 Q8WZ42 A8288V Polymorphism NA 0.288 NA 0 0.238 Q8WZ42 D2240Y Polymorphism 0.786 0.807 NA 0 0.860 Q8WZ42 D4427E Polymorphism NA 0.430 NA 0 0.356 Q8WZ42 G1137R Polymorphism NA 0.712 NA 0 0.570 Q8WZ42 G1345D Polymorphism NA 0.768 NA 0 0.515 Q8WZ42 G2392S Polymorphism 0.493 0.701 NA 0 0.460 Q8WZ42 G4238W Polymorphism NA 0.220 NA 0 0.385 Q8WZ42 G4303D Polymorphism NA 0.906 NA 0 0.650 Q8WZ42 I1393V Polymorphism NA 0.074 NA 0 0.191 Q8WZ42 I1544V Polymorphism NA 0.046 NA 0 0.203 Q8WZ42 I2118T Polymorphism 0.416 0.709 NA 0 0.532 Q8WZ42 I3762V Polymorphism NA 0.158 NA 0 0.120 Q8WZ42 I3877F Polymorphism NA 0.109 NA 0 0.110 Q8WZ42 I3965L Polymorphism NA 0.088 NA 0 0.092 Q8WZ42 I8474T Polymorphism NA 0.180 NA 0 0.232 Q8WZ42 K1201E Polymorphism NA 0.434 NA 0 0.365 Q8WZ42 K3154R Polymorphism 0.223 0.435 NA 0 0.323 Q8WZ42 L3590V Polymorphism NA 0.851 NA 0 0.497 Q8WZ42 L4283F Polymorphism NA 0.419 NA 0 0.330 Q8WZ42 N3026I Polymorphism 0.196 0.338 NA 0 0.133 Q8WZ42 P1744L Polymorphism 0.694 0.654 NA 0 0.654 Q8WZ42 P3637S Polymorphism NA 0.630 NA 0 0.414 Q8WZ42 Q3191E Polymorphism 0.067 0.519 NA 0 0.048 Q8WZ42 R1416C Polymorphism NA 0.409 NA 0 0.496 Q8WZ42 R1441P Polymorphism NA 0.591 NA 0 0.554 Q8WZ42 R1658G Polymorphism 0.411 0.705 NA 0 0.534 Q8WZ42 R1998H Polymorphism 0.659 0.389 NA 0 0.607 Q8WZ42 R3367Q Polymorphism NA 0.576 NA 0 0.448 Q8WZ42 R4084Q Polymorphism NA 0.133 NA 0 0.130 Q8WZ42 S1249L Polymorphism NA 0.494 NA 0 0.532 Q8WZ42 S1772G Polymorphism 0.420 0.509 NA 0 0.453 Q8WZ42 S3419N Polymorphism NA 0.330 NA 0 0.407 Q8WZ42 S3491P Polymorphism NA 0.779 NA 0 0.478 Q8WZ42 S3799Y Disease NA 0.128 NA 0 0.109 Q8WZ42 S4465N Disease NA 0.449 NA 0 0.368 Q8WZ42 T4215P Polymorphism NA 0.136 NA 0 0.134 Q8WZ42 V1202A Polymorphism NA 0.229 NA 0 0.356 Q8WZ42 V1353L Polymorphism NA 0.196 NA 0 0.375 Q8WZ42 V2823F Polymorphism 0.379 0.386 NA 0 0.320 Q8WZ42 V2930I Polymorphism 0.156 0.690 NA 0 0.200 Q8WZ42 V3250G Polymorphism 0.516 0.579 NA 0 0.470 Q8WZ42 V3261M Polymorphism 0.213 0.412 NA 0 0.276 Q8WZ42 A13418T Polymorphism NA 0.568 NA 0 0.462 Q8WZ42 A15520V Polymorphism NA 0.579 NA 0 0.441 Q8WZ42 A18222T Polymorphism NA 0.552 NA 0 0.439 Q8WZ42 A20198T Polymorphism NA 0.364 NA 0 0.429 Q8WZ42 A20198V Polymorphism NA 0.468 NA 0 0.437 Q8WZ42 A22045V Polymorphism NA 0.330 NA 0 0.218 Q8WZ42 A22770D Polymorphism NA 0.750 NA 0 0.710 Q8WZ42 A24098G Polymorphism NA 0.159 NA 0 0.231 Q8WZ42 A24098T Polymorphism NA 0.208 NA 0 0.401 Q8WZ42 A25679T Polymorphism NA 0.249 NA 0 0.232 Q8WZ42 A25923V Polymorphism NA 0.390 NA 0 0.359 Q8WZ42 A28948T Polymorphism NA 0.373 NA 0 0.359 Q8WZ42 A31124G Polymorphism NA 0.455 NA 0 0.430 Q8WZ42 C31690R Polymorphism NA 0.793 NA 0 0.478 Q8WZ42 D13469N Polymorphism NA 0.406 NA 0 0.226 Q8WZ42 D17866N Polymorphism NA 0.668 NA 0 0.459 Q8WZ42 D19495G Polymorphism NA 0.176 NA 0 0.245 Q8WZ42 D21125E Polymorphism NA 0.241 NA 0 0.195 Q8WZ42 D24954H Polymorphism NA 0.530 NA 0 0.633 Q8WZ42 D26843Y Polymorphism NA 0.581 NA 0 0.616 Q8WZ42 D29976E Polymorphism NA 0.285 NA 0 0.353 Q8WZ42 E13049G Polymorphism NA 0.521 NA 0 0.422 Q8WZ42 E13428V Polymorphism NA 0.320 NA 0 0.358 Q8WZ42 E18094A Polymorphism NA 0.054 NA 0 0.174 Q8WZ42 E22968Q Polymorphism NA 0.359 NA 0 0.359 Q8WZ42 E24265K Polymorphism NA 0.276 NA 0 0.309 Q8WZ42 E30825K Polymorphism NA 0.665 NA 0 0.453 Q8WZ42 E33419D Polymorphism NA 0.366 NA 0 0.361 Q8WZ42 E33616K Polymorphism NA 0.137 NA 0 0.241 Q8WZ42 E33886V Polymorphism NA 0.184 NA 0 0.295 Q8WZ42 F27754L Polymorphism NA 0.460 NA 0 0.365 Q8WZ42 F30818I Polymorphism NA 0.577 NA 0 0.463 Q8WZ42 G12310E Polymorphism NA 0.808 NA 0 0.479 Q8WZ42 G18109S Polymorphism NA 0.796 NA 0 0.472 Q8WZ42 G19947R Polymorphism NA 0.898 NA 0 0.672 Q8WZ42 G21925R Polymorphism NA 0.919 NA 0 0.666 Q8WZ42 G27728V Polymorphism NA 0.855 NA 0 0.658 Q8WZ42 G28993E Polymorphism NA 0.731 NA 0 0.455 Q8WZ42 G30887D Polymorphism NA 0.853 NA 0 0.666 Q8WZ42 G30887S Polymorphism NA 0.849 NA 0 0.486 Q8WZ42 G31732S Polymorphism NA 0.828 NA 0 0.661 Q8WZ42 G32637V Polymorphism NA 0.655 NA 0 0.285 Q8WZ42 I13399M Polymorphism NA 0.353 NA 0 0.238 Q8WZ42 I13430T Polymorphism NA 0.396 NA 0 0.200 Q8WZ42 I15837M Polymorphism NA 0.132 NA 0 0.240 Q8WZ42 I16090T Polymorphism NA 0.681 NA 0 0.461 Q8WZ42 I16629M Polymorphism NA 0.144 NA 0 0.240 Q8WZ42 I17637V Polymorphism NA 0.196 NA 0 0.269 Q8WZ42 I22261T Polymorphism NA 0.302 NA 0 0.216 Q8WZ42 I24584T Polymorphism NA 0.425 NA 0 0.362 Q8WZ42 I24781T Polymorphism NA 0.463 NA 0 0.371 Q8WZ42 I26134V Polymorphism NA 0.211 NA 0 0.278 Q8WZ42 I27755T Polymorphism NA 0.054 NA 0 0.152 Q8WZ42 I27929V Polymorphism NA 0.172 NA 0 0.243 Q8WZ42 I28132L Polymorphism NA 0.214 NA 0 0.219 Q8WZ42 I28572T Polymorphism NA 0.283 NA 0 0.213 Q8WZ42 I28986V Polymorphism NA 0.059 NA 0 0.216 Q8WZ42 I29090V Polymorphism NA 0.047 NA 0 0.225 Q8WZ42 I30412T Polymorphism NA 0.304 NA 0 0.307 Q8WZ42 I30856T Polymorphism NA 0.172 NA 0 0.261 Q8WZ42 I31081F Polymorphism NA 0.558 NA 0 0.459 Q8WZ42 I32558V Polymorphism NA 0.051 NA 0 0.166 Q8WZ42 I33899T Polymorphism NA 0.126 NA 0 0.237 Q8WZ42 I34306N Disease NA 0.500 NA 0 0.637 Q8WZ42 K12679E Polymorphism NA 0.785 NA 0 0.476 Q8WZ42 K13495N Polymorphism NA 0.441 NA 0 0.222 Q8WZ42 K16067I Polymorphism NA 0.500 NA 0 0.462 Q8WZ42 K22306N Polymorphism NA 0.644 NA 0 0.528 Q8WZ42 K27346R Polymorphism NA 0.140 NA 0 0.229 Q8WZ42 K33568Q Polymorphism NA 0.066 NA 0 0.223 Q8WZ42 L15705P Polymorphism NA 0.851 NA 0 0.482 Q8WZ42 L22408P Polymorphism NA 0.903 NA 0 0.483 Q8WZ42 L28998V Polymorphism NA 0.448 NA 0 0.362 Q8WZ42 L29479P Polymorphism NA 0.715 NA 0 0.454 Q8WZ42 L30211P Polymorphism NA 0.741 NA 0 0.400 Q8WZ42 L34315P Disease NA 0.880 NA 0 0.828 Q8WZ42 M32610V Polymorphism NA 0.081 NA 0 0.208 Q8WZ42 N15021T Polymorphism NA 0.517 NA 0 0.459 Q8WZ42 N17060D Polymorphism NA 0.483 NA 0 0.297 Q8WZ42 N18939S Polymorphism NA 0.220 NA 0 0.232 Q8WZ42 N24119S Polymorphism NA 0.347 NA 0 0.314 Q8WZ42 N25879K Polymorphism NA 0.542 NA 0 0.530 Q8WZ42 N31156S Polymorphism NA 0.328 NA 0 0.199 Q8WZ42 P14208T Polymorphism NA 0.466 NA 0 0.335 Q8WZ42 P18221L Polymorphism NA 0.468 NA 0 0.374 Q8WZ42 P21403S Polymorphism NA 0.684 NA 0 0.463 Q8WZ42 P22584L Polymorphism NA 0.565 NA 0 0.470 Q8WZ42 P23074L Polymorphism NA 0.500 NA 0 0.461 Q8WZ42 P25720A Polymorphism NA 0.120 NA 0 0.241 Q8WZ42 P31246T Polymorphism NA 0.632 NA 0 0.468 Q8WZ42 P33620L Polymorphism NA 0.104 NA 0 0.244 Q8WZ42 Q32281H Polymorphism NA 0.928 NA 0 0.821 Q8WZ42 R12383H Polymorphism NA 0.363 NA 0 0.235 Q8WZ42 R12798C Polymorphism NA 0.717 NA 0 0.423 Q8WZ42 R13096L Polymorphism NA 0.590 NA 0 0.429 Q8WZ42 R14131Q Polymorphism NA 0.557 NA 0 0.456 Q8WZ42 R15620Q Polymorphism NA 0.232 NA 0 0.212 Q8WZ42 R15700Q Polymorphism NA 0.711 NA 0 0.456 Q8WZ42 R16058H Polymorphism NA 0.356 NA 0 0.424 Q8WZ42 R16409C Polymorphism NA 0.403 NA 0 0.415 Q8WZ42 R16424P Polymorphism NA 0.701 NA 0 0.451 Q8WZ42 R17838H Polymorphism NA 0.319 NA 0 0.416 Q8WZ42 R18726Q Polymorphism NA 0.146 NA 0 0.232 Q8WZ42 R19000Q Polymorphism NA 0.740 NA 0 0.460 Q8WZ42 R19665H Polymorphism NA 0.500 NA 0 0.469 Q8WZ42 R19992Q Polymorphism NA 0.795 NA 0 0.473 Q8WZ42 R20057C Polymorphism NA 0.385 NA 0 0.430 Q8WZ42 R20331H Polymorphism NA 0.298 NA 0 0.213 Q8WZ42 R20359K Polymorphism NA 0.407 NA 0 0.310 Q8WZ42 R20564K Polymorphism NA 0.194 NA 0 0.302 Q8WZ42 R21730C Polymorphism NA 0.507 NA 0 0.521 Q8WZ42 R21747Q Polymorphism NA 0.570 NA 0 0.457 Q8WZ42 R21995H Polymorphism NA 0.532 NA 0 0.547 Q8WZ42 R22149H Polymorphism NA 0.269 NA 0 0.238 Q8WZ42 R22357H Polymorphism NA 0.802 NA 0 0.568 Q8WZ42 R23306C Polymorphism NA 0.560 NA 0 0.531 Q8WZ42 R24799H Polymorphism NA 0.253 NA 0 0.435 Q8WZ42 R25659H Polymorphism NA 0.190 NA 0 0.392 Q8WZ42 R26477C Polymorphism NA 0.742 NA 0 0.713 Q8WZ42 R27652C Polymorphism NA 0.260 NA 0 0.483 Q8WZ42 R28168Q Polymorphism NA 0.795 NA 0 0.470 Q8WZ42 R28538H Polymorphism NA 0.312 NA 0 0.353 Q8WZ42 R29419C Polymorphism NA 0.568 NA 0 0.628 Q8WZ42 R30107C Polymorphism NA 0.530 NA 0 0.459 Q8WZ42 R30897H Polymorphism NA 0.627 NA 0 0.530 Q8WZ42 R30907H Polymorphism NA 0.491 NA 0 0.555 Q8WZ42 R30946H Polymorphism NA 0.349 NA 0 0.410 Q8WZ42 R31107C Polymorphism NA 0.631 NA 0 0.632 Q8WZ42 R31330H Polymorphism NA 0.888 NA 0 0.682 Q8WZ42 R31724Q Polymorphism NA 0.858 NA 0 0.495 Q8WZ42 R32097C Polymorphism NA 0.487 NA 0 0.464 Q8WZ42 R32323H Polymorphism NA 0.795 NA 0 0.650 Q8WZ42 R32953H Polymorphism NA 0.318 NA 0 0.483 Q8WZ42 R32996Q Disease NA 0.204 NA 0 0.329 Q8WZ42 S14999T Polymorphism NA 0.615 NA 0 0.464 Q8WZ42 S15629I Polymorphism NA 0.563 NA 0 0.438 Q8WZ42 S20075L Polymorphism NA 0.225 NA 0 0.436 Q8WZ42 S20726P Polymorphism NA 0.579 NA 0 0.520 Q8WZ42 S20894R Polymorphism NA 0.872 NA 0 0.478 Q8WZ42 S23807N Polymorphism NA 0.253 NA 0 0.307 Q8WZ42 S30042G Polymorphism NA 0.086 NA 0 0.241 Q8WZ42 S30125F Polymorphism NA 0.522 NA 0 0.531 Q8WZ42 T19367I Polymorphism NA 0.169 NA 0 0.233 Q8WZ42 T19762I Polymorphism NA 0.210 NA 0 0.176 Q8WZ42 T20179K Polymorphism NA 0.305 NA 0 0.356 Q8WZ42 T20892N Polymorphism NA 0.455 NA 0 0.413 Q8WZ42 T22670A Polymorphism NA 0.165 NA 0 0.236 Q8WZ42 T23939M Polymorphism NA 0.416 NA 0 0.431 Q8WZ42 T24239A Polymorphism NA 0.211 NA 0 0.405 Q8WZ42 T24980M Polymorphism NA 0.243 NA 0 0.435 Q8WZ42 T25821K Polymorphism NA 0.306 NA 0 0.354 Q8WZ42 T30674I Polymorphism NA 0.333 NA 0 0.358 Q8WZ42 T33387M Polymorphism NA 0.135 NA 0 0.260 Q8WZ42 T33955I Polymorphism NA 0.364 NA 0 0.361 Q8WZ42 V12469A Polymorphism NA 0.409 NA 0 0.425 Q8WZ42 V13297A Polymorphism NA 0.600 NA 0 0.417 Q8WZ42 V14109I Polymorphism NA 0.475 NA 0 0.394 Q8WZ42 V16575M Polymorphism NA 0.398 NA 0 0.431 Q8WZ42 V19956M Polymorphism NA 0.568 NA 0 0.469 Q8WZ42 V20718I Polymorphism NA 0.071 NA 0 0.175 Q8WZ42 V22160I Polymorphism NA 0.340 NA 0 0.357 Q8WZ42 V23891A Polymorphism NA 0.197 NA 0 0.308 Q8WZ42 V24133I Polymorphism NA 0.177 NA 0 0.249 Q8WZ42 V26045I Polymorphism NA 0.095 NA 0 0.245 Q8WZ42 V29070M Polymorphism NA 0.447 NA 0 0.429 Q8WZ42 V31725I Polymorphism NA 0.797 NA 0 0.480 Q8WZ42 V31886I Polymorphism NA 0.553 NA 0 0.463 Q8WZ42 V32248I Polymorphism NA 0.469 NA 0 0.400 Q8WZ42 V32922A Polymorphism NA 0.288 NA 0 0.395 Q8WZ42 V33213L Polymorphism NA 0.225 NA 0 0.392 Q8WZ42 V33536M Polymorphism NA 0.047 NA 0 0.208 Q8WZ42 V34115A Polymorphism NA 0.295 NA 0 0.419 Q8WZ42 Y23933H Polymorphism NA 0.323 NA 0 0.407 Q8WZ55 R8L Disease NA 0.751 NA 57 0.853 Q8WZ55 R8W Disease NA 0.793 NA 63 0.883 Q8WZ55 G10S Disease NA 0.570 NA 56 0.705 Q8WZ55 G47R Disease NA 0.404 NA 56 0.398 Q8WZ64 K384N Polymorphism NA 0.188 NA 26 0.111 Q8WZ79 K47R Polymorphism 0.713 0.905 0.00 53 0.908 Q8WZ84 C127W Polymorphism 0.966 0.931 0.05 71 0.932 Q8WZ84 F102V Polymorphism 0.356 0.720 0.08 35 0.764 Q8WZ84 L194P Polymorphism 0.596 0.834 0.01 62 0.888 Q8WZ92 G7R Polymorphism 0.176 0.850 0.51 17 0.369 Q8WZA0 G104D Polymorphism NA 0.246 0.40 -6 0.220 Q8WZA1 C269Y Disease 0.580 0.818 0.07 47 0.838 Q8WZA1 C490Y Disease 0.799 0.944 0.00 51 0.918 Q8WZA1 E223K Disease 0.268 0.335 0.02 48 0.381 Q8WZA1 E250V Polymorphism 0.290 0.146 0.00 42 0.186 Q8WZA1 P493R Disease 0.722 0.940 0.00 67 0.942 Q8WZA1 R265H Disease 0.327 0.438 0.00 36 0.572 Q8WZA1 R311Q Disease 0.469 0.817 0.00 64 0.894 Q8WZA1 R442C Disease 0.847 0.972 0.00 65 0.947 Q8WZA1 S550N Disease 0.530 0.076 0.00 -8 0.106 Q8WZA1 V504I Polymorphism 0.214 0.049 0.28 -8 0.086 Q8WZA1 W425S Disease 0.731 0.956 0.00 60 0.936 Q92466 A293T Polymorphism 0.385 0.328 0.40 -29 0.448 Q92466 K244E Disease 0.431 0.515 0.99 50 0.749 Q92466 M215T Polymorphism 0.163 0.157 0.23 32 0.073 Q92466 R273H Disease 0.581 0.846 0.10 34 0.825 Q92481 P73R Disease 0.872 0.544 0.04 10 0.758 Q92481 A275D Disease 0.880 0.934 0.00 38 0.897 Q92481 R236C Disease 0.973 0.941 0.00 55 0.964 Q92481 R236S Disease 0.912 0.867 0.00 48 0.916 Q92481 R285Q Disease 0.886 0.876 0.00 12 0.881 Q92481 R300C Disease 0.959 0.949 0.00 45 0.945 Q92482 V43M Polymorphism 0.403 0.850 0.02 17 0.731 Q92484 P161S Polymorphism 0.460 0.765 0.44 22 0.598 Q92485 R381H Polymorphism 0.590 0.639 0.12 29 0.598 Q92496 G306E Polymorphism 0.545 0.761 0.01 60 0.873 Q92503 V37M Polymorphism NA 0.194 0.16 34 0.380 Q92504 D87N Polymorphism 0.215 0.154 0.62 -21 0.081 Q92504 E280G Polymorphism 0.278 0.215 0.37 14 0.294 Q92504 G124R Polymorphism 0.125 0.218 0.53 17 0.260 Q92506 H190R Polymorphism 0.252 0.055 1.00 -26 0.017 Q92521 I68L Polymorphism 0.663 0.151 0.77 -57 0.134 Q92523 S427C Polymorphism 0.213 0.414 0.19 -33 0.328 Q92523 S664Y Polymorphism 0.872 0.657 0.00 -6 0.812 Q92530 F36C Polymorphism 0.173 0.610 0.04 -23 0.393 Q92530 H174R Polymorphism 0.131 0.045 0.72 -10 0.065 Q92539 S734L Disease 0.879 0.894 0.01 34 0.899 Q92540 S627F Polymorphism 0.644 0.148 0.15 18 0.247 Q92542 E77D Polymorphism 0.159 0.220 0.77 0 0.188 Q92542 V75I Polymorphism 0.269 0.092 0.67 -34 0.167 Q92547 N955S Polymorphism 0.086 0.033 0.68 1 0.053 Q92547 S817L Polymorphism 0.616 0.156 0.00 26 0.254 Q92547 N1042S Polymorphism 0.259 0.040 0.41 -12 0.055 Q92561 R21S Polymorphism NA 0.155 0.02 31 0.164 Q92562 D48G Polymorphism NA 0.465 0.33 6 0.449 Q92562 D53Y Disease NA 0.598 0.01 58 0.749 Q92562 I41T Disease NA 0.756 0.00 49 0.845 Q92562 I411V Polymorphism 0.332 0.354 0.21 -5 0.343 Q92562 I902T Polymorphism NA 0.225 NA -7 0.143 Q92562 V654A Polymorphism 0.058 0.078 1.00 8 0.054 Q92562 Y647C Polymorphism 0.415 0.188 0.07 13 0.357 Q92563 G353S Polymorphism 0.375 0.806 0.01 34 0.747 Q92574 E51D Disease 0.252 0.185 NA -20 0.197 Q92574 L72P Disease 0.281 0.885 NA 40 0.721 Q92574 A726E Disease 0.190 0.424 0.05 39 0.436 Q92574 E577D Polymorphism 0.240 0.070 NA 15 0.046 Q92574 E809Q Polymorphism 0.108 0.111 0.12 11 0.095 Q92574 H732Y Disease 0.382 0.233 0.04 36 0.385 Q92574 L191H Disease 0.940 0.919 NA 56 0.953 Q92574 M224R Disease 0.219 0.370 NA 26 0.406 Q92574 M322T Polymorphism 0.150 0.055 NA -18 0.036 Q92574 Q654E Disease 0.155 0.171 0.06 4 0.080 Q92574 R190S Polymorphism 0.509 0.910 NA 29 0.759 Q92574 R500Q Disease 0.205 0.448 NA 28 0.287 Q92574 S829R Polymorphism 0.644 0.130 0.01 21 0.134 Q92574 T417I Disease 0.325 0.091 NA 23 0.060 Q92574 T899S Disease 0.121 0.055 0.06 -39 0.055 Q92574 G1035S Polymorphism 0.101 0.099 NA -18 0.046 Q92574 G1108S Polymorphism 0.172 0.031 NA -40 0.020 Q92575 S458R Polymorphism 0.328 0.170 0.00 27 0.208 Q92576 V525I Polymorphism NA 0.110 0.12 12 0.078 Q92576 H1834Y Polymorphism NA 0.171 NA 28 0.151 Q92583 K5N Polymorphism 0.290 0.190 0.41 -14 0.174 Q92583 V67M Polymorphism 0.455 0.105 0.06 41 0.091 Q92585 S1007N Polymorphism 0.154 0.023 0.25 -49 0.042 Q92597 M67V Polymorphism 0.248 0.531 0.02 52 0.723 Q92597 M111L Polymorphism 0.176 0.186 0.14 13 0.181 Q92600 I143T Polymorphism 0.602 0.960 0.00 49 0.897 Q92608 D1558A Polymorphism 0.120 0.221 0.24 -5 0.221 Q92608 S1746T Polymorphism 0.120 0.157 0.92 -25 0.044 Q92608 T1779S Polymorphism 0.127 0.081 0.13 -35 0.017 Q92609 I696V Polymorphism NA 0.032 NA -2 0.026 Q92614 A958V Polymorphism 0.156 0.051 1.00 12 0.035 Q92618 N4S Polymorphism NA 0.047 0.04 -16 0.059 Q92619 A886P Polymorphism 0.534 0.656 0.25 30 0.626 Q92619 M515I Polymorphism 0.233 0.370 0.21 22 0.464 Q92625 L694S Polymorphism 0.076 0.095 0.24 -19 0.029 Q92629 R96Q Polymorphism 0.086 0.733 0.00 40 0.397 Q92629 E261K Disease 0.619 0.850 0.50 38 0.747 Q92629 S150A Disease 0.237 0.352 0.19 10 0.217 Q92630 S98G Polymorphism NA 0.118 0.90 5 0.085 Q92630 F455Y Polymorphism NA 0.550 0.23 16 0.429 Q92636 Y626C Polymorphism 0.873 0.868 0.17 13 0.862 Q92643 T16A Polymorphism NA 0.121 0.58 -68 0.086 Q92665 T241M Polymorphism 0.189 0.122 0.07 -2 0.178 Q92667 A18V Polymorphism 0.503 0.417 0.00 20 0.420 Q92673 A528T Polymorphism 0.242 0.118 0.01 16 0.283 Q92681 F62L Polymorphism 0.334 0.147 0.00 45 0.094 Q92681 N271S Polymorphism 0.057 0.039 0.85 -14 0.012 Q92685 G118D Disease 0.817 0.970 0.13 64 0.942 Q92685 I107V Polymorphism 0.180 0.515 0.42 -28 0.282 Q92685 R171Q Disease 0.846 0.945 0.00 60 0.944 Q92698 D21G Polymorphism 0.071 0.083 0.04 24 0.094 Q92698 I74M Polymorphism NA 0.177 0.22 25 0.278 Q92698 I583T Polymorphism 0.522 0.223 0.36 24 0.568 Q92698 K151E Polymorphism 0.250 0.224 0.29 18 0.356 Q92698 R202C Polymorphism 0.309 0.548 0.16 4 0.459 Q92698 R380Q Polymorphism 0.474 0.191 0.17 9 0.310 Q92698 R534C Polymorphism 0.823 0.291 0.06 35 0.640 Q92729 T60N Polymorphism NA 0.175 0.25 37 0.168 Q92729 N940S Polymorphism 0.134 0.173 0.28 6 0.147 Q92729 R471L Polymorphism NA 0.553 0.70 48 0.610 Q92730 P44R Polymorphism 0.843 0.911 0.00 76 0.932 Q92734 V43F Polymorphism 0.544 0.584 NA 27 0.715 Q92734 T364P Polymorphism 0.605 0.388 0.35 -6 0.484 Q92750 I249V Polymorphism 0.105 0.032 0.35 14 0.031 Q92752 G293S Polymorphism NA 0.505 0.61 -32 0.410 Q92759 R337Q Polymorphism 0.381 0.789 0.00 28 0.614 Q92764 S36P Polymorphism NA 0.584 0.09 33 0.735 Q92764 C441Y Polymorphism NA 0.622 0.14 39 0.526 Q92765 R200W Polymorphism 0.859 0.500 0.00 30 0.750 Q92765 R324G Polymorphism NA 0.203 0.01 38 0.268 Q92766 G783V Polymorphism 0.050 0.070 0.41 21 0.125 Q92766 D1171N Polymorphism 0.413 0.202 0.31 51 0.397 Q92766 G1384R Polymorphism NA 0.127 0.25 47 0.122 Q92766 L1467P Polymorphism NA 0.298 0.18 30 0.185 Q92766 S1499Y Polymorphism NA 0.104 0.03 46 0.143 Q92769 R230C Polymorphism 0.710 0.444 0.02 34 0.667 Q92769 Y315H Polymorphism 0.612 0.788 0.13 6 0.556 Q92772 Y77S Polymorphism 0.507 0.568 0.06 43 0.583 Q92772 I132T Polymorphism 0.713 0.451 0.02 35 0.685 Q92777 T506A Polymorphism 0.098 0.107 0.49 -12 0.086 Q92781 G35S Disease 0.971 0.895 0.00 65 0.952 Q92781 I33V Polymorphism 0.500 0.228 0.67 -1 0.321 Q92781 S73F Disease 0.876 0.884 0.01 28 0.875 Q92781 A294P Disease NA 0.507 0.03 27 0.596 Q92781 C267W Disease 0.971 0.598 0.02 48 0.832 Q92781 G107R Disease 0.897 0.914 0.03 48 0.891 Q92781 G238W Disease NA 0.905 0.02 41 0.862 Q92781 R280H Disease 0.507 0.848 0.05 38 0.744 Q92781 V132M Disease 0.381 0.313 0.28 -1 0.338 Q92781 V164F Disease 0.497 0.865 0.17 48 0.793 Q92781 V177G Disease 0.557 0.581 0.20 30 0.499 Q92781 Y281H Disease 0.847 0.854 0.00 72 0.930 Q92791 Q186R Polymorphism 0.129 0.140 0.94 -5 0.108 Q92793 E1278K Disease 0.929 0.786 0.00 44 0.904 Q92793 H1470R Disease 0.906 0.651 0.01 60 0.900 Q92793 R1378P Disease 0.813 0.789 0.12 62 0.842 Q92793 R1664H Disease 0.899 0.921 0.00 64 0.945 Q92793 T1447I Disease 0.943 0.913 0.00 51 0.943 Q92793 V1414I Polymorphism 0.676 0.752 0.00 37 0.809 Q92793 Y1175C Disease 0.954 0.878 0.10 54 0.941 Q92793 Y1450H Disease 0.924 0.931 0.00 61 0.948 Q92802 Y272H Polymorphism NA 0.099 0.89 36 0.031 Q92817 Q433R Polymorphism 0.061 0.084 0.46 -21 0.106 Q92817 Y168C Polymorphism 0.764 0.263 0.01 39 0.558 Q92817 P1814S Polymorphism NA 0.085 0.17 -28 0.184 Q92820 C6R Polymorphism NA 0.152 0.84 -24 0.019 Q92820 A31T Polymorphism 0.289 0.097 0.80 -41 0.073 Q92820 T151I Polymorphism 0.561 0.226 0.14 14 0.429 Q92828 R296H Polymorphism 0.896 0.805 0.01 38 0.864 Q92832 F211V Polymorphism NA 0.231 0.68 -4 0.145 Q92832 V287I Polymorphism NA 0.100 0.65 -9 0.091 Q92834 G43E Disease 0.928 0.825 0.00 75 0.915 Q92834 G43R Disease 0.945 0.834 0.00 75 0.979 Q92834 G60V Disease 0.940 0.858 0.01 73 0.983 Q92834 H98Q Disease 0.918 0.425 0.01 67 0.671 Q92834 I75V Disease 0.109 0.351 0.83 5 0.158 Q92834 T99N Disease 0.637 0.300 0.02 50 0.620 Q92834 A262G Disease 0.363 0.167 0.46 46 0.183 Q92834 C250R Disease 0.806 0.621 0.01 72 0.964 Q92834 C250Y Disease 0.848 0.602 0.01 65 0.962 Q92834 C302R Disease 0.931 0.758 0.01 73 0.974 Q92834 C302Y Disease 0.950 0.752 0.01 66 0.975 Q92834 D312N Disease 0.248 0.449 0.08 45 0.348 Q92834 D312Y Disease 0.653 0.452 0.00 52 0.658 Q92834 E285G Disease 0.416 0.216 0.39 44 0.406 Q92834 F130C Disease 0.861 0.226 0.19 49 0.569 Q92834 G173R Disease 0.944 0.820 0.00 73 0.952 Q92834 G215V Disease 0.999 0.809 0.00 65 0.989 Q92834 G267E Disease 0.998 0.664 0.00 77 0.990 Q92834 G267R Disease 0.998 0.734 0.00 77 0.993 Q92834 G275S Disease 0.863 0.746 0.01 59 0.874 Q92834 G320R Disease 0.805 0.869 0.00 77 0.975 Q92834 G436D Disease 0.235 0.136 0.16 -1 0.186 Q92834 G566E Polymorphism 0.705 0.424 0.23 6 0.411 Q92834 I289V Disease 0.220 0.413 0.44 44 0.317 Q92834 I431V Polymorphism 0.150 0.152 0.17 -15 0.095 Q92834 N345D Polymorphism 0.476 0.331 0.27 6 0.231 Q92834 P235S Disease 0.663 0.531 0.05 57 0.568 Q92834 R127G Disease 0.682 0.223 0.38 35 0.537 Q92834 S152L Disease 0.882 0.196 0.11 42 0.560 Q92834 T533M Polymorphism 0.071 0.056 0.23 10 0.045 Q92838 C60R Disease 0.241 0.730 0.04 45 0.701 Q92838 E63K Disease 0.239 0.541 0.03 28 0.618 Q92838 H54Y Disease 0.362 0.509 0.22 12 0.598 Q92838 L55R Disease 0.311 0.850 0.00 25 0.687 Q92838 R65G Disease NA 0.457 0.05 46 0.454 Q92838 R69L Disease NA 0.324 0.00 30 0.221 Q92838 Y61H Disease 0.390 0.381 0.00 33 0.241 Q92838 A349T Disease 0.239 0.352 0.00 48 0.432 Q92838 A356D Disease 0.382 0.717 0.36 42 0.657 Q92838 C332Y Disease 0.578 0.742 0.01 61 0.832 Q92838 D298H Disease 0.497 0.582 0.06 51 0.634 Q92838 D298Y Disease 0.606 0.740 0.04 51 0.830 Q92838 F302S Disease 0.409 0.858 0.00 32 0.733 Q92838 G189E Disease 0.554 0.166 0.00 63 0.371 Q92838 G198A Disease 0.286 0.186 0.01 38 0.329 Q92838 G207R Disease 0.513 0.272 0.00 64 0.546 Q92838 G218D Disease 0.999 0.139 0.00 60 0.547 Q92838 G224A Disease 0.286 0.165 0.01 50 0.347 Q92838 G255C Disease 0.655 0.476 0.02 43 0.607 Q92838 G255D Disease 0.435 0.495 0.13 20 0.606 Q92838 G269V Disease 0.479 0.719 0.00 0 0.586 Q92838 G291R Disease NA 0.529 0.00 44 0.646 Q92838 G291W Disease NA 0.608 0.00 47 0.639 Q92838 G299S Disease 0.320 0.576 0.00 45 0.296 Q92838 H252L Disease 0.332 0.394 0.57 15 0.207 Q92838 H252Y Disease 0.315 0.400 0.08 14 0.230 Q92838 I360N Disease 0.530 0.774 0.00 39 0.765 Q92838 K158N Disease 0.243 0.251 0.32 11 0.203 Q92838 M373I Disease NA 0.436 0.03 41 0.412 Q92838 N372D Disease NA 0.185 0.01 55 0.262 Q92838 P209L Disease 0.443 0.238 0.01 26 0.201 Q92838 Q306H Disease 0.412 0.715 0.00 65 0.839 Q92838 Q358E Disease 0.200 0.561 0.08 34 0.579 Q92838 R153C Disease 0.635 0.129 0.04 42 0.227 Q92838 R155C Disease 0.557 0.135 0.02 35 0.189 Q92838 R156C Disease 0.581 0.165 0.17 43 0.204 Q92838 R156H Disease 0.379 0.128 0.02 40 0.285 Q92838 R156S Disease 0.203 0.207 0.46 35 0.245 Q92838 R357P Disease 0.501 0.771 0.38 41 0.700 Q92838 S374R Disease NA 0.577 0.00 44 0.642 Q92838 T378M Disease 0.475 0.378 0.00 53 0.453 Q92838 T378P Disease 0.407 0.513 0.00 51 0.642 Q92838 V307G Disease 0.420 0.756 0.00 53 0.795 Q92838 W274G Disease 0.485 0.778 0.23 45 0.742 Q92838 Y320C Disease 0.671 0.792 0.07 55 0.877 Q92838 Y343C Disease 0.671 0.531 0.00 59 0.809 Q92844 R394Q Polymorphism NA 0.082 NA 11 0.052 Q92847 T5I Polymorphism 0.223 0.297 0.01 48 0.436 Q92847 A204E Disease NA 0.325 0.27 27 0.358 Q92851 A414V Disease 0.345 0.235 0.55 18 0.312 Q92851 I406L Disease 0.157 0.325 1.00 -34 0.155 Q92851 L285F Disease 0.292 0.296 0.09 -14 0.340 Q92851 M147T Disease NA 0.126 0.02 -9 0.199 Q92851 P444S Polymorphism 0.443 0.766 0.11 27 0.579 Q92851 S239C Polymorphism 0.490 0.322 0.02 29 0.408 Q92851 V410I Polymorphism 0.156 0.193 0.53 5 0.211 Q92851 Y446C Polymorphism 0.756 0.913 0.19 27 0.769 Q92859 P534L Polymorphism 0.274 0.257 0.05 20 0.326 Q92878 K973M Polymorphism 0.330 0.071 0.00 25 0.164 Q92878 T191I Polymorphism 0.527 0.186 0.19 -29 0.375 Q92878 V315L Polymorphism 0.207 0.111 0.25 -10 0.118 Q92878 V842A Polymorphism 0.204 0.038 0.18 -3 0.089 Q92878 Y964H Polymorphism 0.612 0.559 0.57 60 0.660 Q92882 N48S Polymorphism NA 0.217 0.76 7 0.332 Q92882 L159F Polymorphism 0.190 0.747 0.12 32 0.619 Q92887 D333G Polymorphism 0.559 0.542 0.28 7 0.472 Q92887 I670T Polymorphism 0.321 0.481 0.01 37 0.466 Q92887 I982V Polymorphism 0.168 0.058 0.51 -40 0.106 Q92887 M246L Polymorphism NA 0.416 0.16 12 0.210 Q92887 R353H Polymorphism 0.111 0.658 0.16 4 0.090 Q92887 R768W Disease 0.999 0.968 0.00 64 0.931 Q92887 S281N Polymorphism NA 0.328 0.15 27 0.335 Q92887 S789F Polymorphism 0.948 0.872 0.00 61 0.920 Q92887 I1173F Disease 0.880 0.789 0.00 56 0.903 Q92887 N1063S Polymorphism 0.456 0.043 0.87 -23 0.050 Q92887 P1291L Polymorphism 0.720 0.564 0.58 25 0.760 Q92887 Q1382R Disease 0.999 0.872 0.00 63 0.938 Q92887 R1150H Disease 0.991 0.809 0.05 52 0.868 Q92889 V33L Polymorphism 0.251 0.423 0.48 -44 0.274 Q92889 A168V Polymorphism 0.252 0.246 0.05 -28 0.266 Q92889 A860D Polymorphism 0.332 0.405 0.64 -1 0.275 Q92889 E502K Disease 0.288 0.089 1.00 1 0.153 Q92889 E875G Polymorphism 0.549 0.376 0.07 14 0.540 Q92889 G513R Disease 0.171 0.090 0.09 38 0.195 Q92889 G703D Polymorphism 0.617 0.912 0.10 56 0.719 Q92889 G912E Polymorphism NA 0.110 0.00 13 0.153 Q92889 I225M Disease 0.824 0.631 0.00 3 0.727 Q92889 I529T Disease 0.168 0.290 1.00 -9 0.203 Q92889 I706T Polymorphism 0.796 0.780 0.02 35 0.742 Q92889 I717T Polymorphism 0.854 0.887 0.02 32 0.893 Q92889 I873V Polymorphism 0.282 0.064 0.19 -24 0.129 Q92889 L608P Disease 0.906 0.969 0.01 47 0.904 Q92889 P379S Polymorphism 0.269 0.804 0.00 -2 0.622 Q92889 R153P Disease 0.914 0.950 0.01 63 0.945 Q92889 R415Q Polymorphism 0.505 0.587 0.32 41 0.563 Q92889 R454W Disease 0.861 0.182 0.01 40 0.370 Q92889 R490Q Disease 0.166 0.121 0.55 11 0.143 Q92889 R576T Polymorphism 0.464 0.550 0.51 21 0.486 Q92889 R799W Disease 0.968 0.691 0.00 42 0.871 Q92889 S662P Polymorphism 0.206 0.546 0.34 -9 0.335 Q92889 S768F Polymorphism 0.713 0.823 0.67 33 0.853 Q92889 T567A Disease 0.261 0.280 0.61 3 0.289 Q92890 P130A Polymorphism 0.272 0.100 0.91 -24 0.209 Q92900 A69S Polymorphism NA 0.115 0.93 -5 0.063 Q92902 A186V Polymorphism 0.119 0.079 NA -2 0.084 Q92902 A480T Polymorphism 0.191 0.076 NA -1 0.089 Q92902 E100D Polymorphism 0.260 0.521 NA 17 0.679 Q92902 V630I Polymorphism 0.247 0.166 NA 28 0.205 Q92903 L99F Polymorphism 0.160 0.153 0.53 -26 0.082 Q92904 T12A Polymorphism NA 0.211 0.41 24 0.188 Q92911 G93R Disease 0.791 0.921 0.12 44 0.880 Q92911 A102P Polymorphism 0.693 0.899 0.03 21 0.842 Q92911 G395R Disease 0.858 0.918 0.00 66 0.939 Q92911 G543E Disease NA 0.609 0.10 56 0.750 Q92911 Q267E Disease 0.809 0.845 0.00 72 0.919 Q92911 T354P Disease 0.740 0.923 0.01 67 0.933 Q92915 G42C Polymorphism 0.416 0.043 0.01 21 0.108 Q92915 F145S Disease 0.830 0.938 0.00 53 0.930 Q92918 N811S Polymorphism NA 0.413 0.00 18 0.563 Q92918 P312T Polymorphism 0.511 0.117 0.55 5 0.304 Q92922 P1075H Polymorphism 0.702 0.171 0.00 39 0.494 Q92932 S140T Polymorphism NA 0.085 0.01 -17 0.134 Q92935 H379N Polymorphism 0.059 0.091 0.21 38 0.152 Q92935 R163H Polymorphism 0.301 0.338 0.02 45 0.443 Q92947 R88C Disease NA 0.684 0.00 28 0.772 Q92947 R94L Disease NA 0.759 0.28 6 0.456 Q92947 A122V Disease NA 0.490 0.28 38 0.697 Q92947 A195T Disease 0.897 0.809 0.06 48 0.847 Q92947 A293T Disease 0.374 0.599 0.03 4 0.321 Q92947 A298T Polymorphism 0.821 0.843 0.20 50 0.826 Q92947 A349T Disease 0.673 0.227 0.40 15 0.551 Q92947 A382T Disease 0.480 0.653 0.40 -1 0.402 Q92947 A421T Disease 0.462 0.408 0.61 -31 0.265 Q92947 A421V Disease 0.580 0.532 0.34 19 0.727 Q92947 A433E Disease NA 0.952 0.02 71 0.935 Q92947 C115Y Disease NA 0.943 0.39 54 0.898 Q92947 C308S Disease 0.618 0.519 0.42 19 0.491 Q92947 C375R Disease 0.705 0.860 0.06 60 0.907 Q92947 E365K Disease 0.507 0.345 0.94 29 0.561 Q92947 E414K Disease 0.924 0.950 0.03 69 0.918 Q92947 F236L Disease 0.720 0.835 0.13 34 0.607 Q92947 G101R Disease NA 0.927 0.47 38 0.547 Q92947 G178R Disease 0.769 0.934 0.02 69 0.930 Q92947 G354R Disease 0.495 0.895 0.06 53 0.885 Q92947 G354S Disease 0.671 0.643 0.18 -9 0.532 Q92947 G390A Disease 0.970 0.828 0.00 62 0.910 Q92947 G390R Disease 0.995 0.913 0.00 81 0.907 Q92947 H403R Disease 0.597 0.697 0.35 58 0.882 Q92947 L179R Disease 0.967 0.903 0.00 74 0.927 Q92947 L283P Disease 0.796 0.851 0.04 62 0.918 Q92947 L309W Disease 0.847 0.490 0.03 -7 0.650 Q92947 L407P Disease 0.897 0.892 0.20 42 0.882 Q92947 M191T Disease 0.474 0.640 0.03 35 0.549 Q92947 M266V Disease 0.518 0.716 0.04 46 0.820 Q92947 N392D Disease 0.670 0.822 0.24 60 0.902 Q92947 N406K Disease 0.393 0.765 0.12 54 0.837 Q92947 P278S Disease 0.375 0.663 0.75 27 0.564 Q92947 Q333E Disease 0.553 0.872 0.45 53 0.832 Q92947 R128G Disease NA 0.585 0.01 29 0.767 Q92947 R138G Disease 0.528 0.259 1.00 37 0.556 Q92947 R161Q Disease 0.429 0.639 0.14 25 0.500 Q92947 R227P Disease 0.892 0.868 0.04 57 0.926 Q92947 R257Q Disease 0.789 0.847 0.62 68 0.882 Q92947 R257W Disease 0.952 0.942 0.04 68 0.914 Q92947 R294W Disease 0.997 0.912 0.00 74 0.932 Q92947 R313W Disease 0.886 0.824 0.19 32 0.842 Q92947 R355C Disease 0.936 0.690 0.20 35 0.799 Q92947 R355H Disease 0.490 0.575 0.67 13 0.572 Q92947 R383C Disease 0.887 0.781 0.09 33 0.846 Q92947 R383H Disease 0.496 0.580 0.27 11 0.569 Q92947 R386Q Disease 0.545 0.692 0.02 42 0.582 Q92947 R402Q Disease 0.736 0.910 0.28 54 0.902 Q92947 R402W Disease 0.990 0.943 0.00 59 0.933 Q92947 S139L Disease 0.443 0.270 0.48 42 0.405 Q92947 S305L Disease 0.437 0.682 0.24 -14 0.211 Q92947 T416I Disease 0.970 0.909 0.08 57 0.924 Q92947 T429M Disease 0.358 0.744 0.10 50 0.799 Q92947 V148I Disease 0.366 0.197 0.39 50 0.429 Q92947 V400M Disease 0.782 0.863 0.20 33 0.614 Q92947 Y295H Disease 0.736 0.635 0.00 38 0.807 Q92953 E657G Polymorphism 0.131 0.075 0.38 15 0.034 Q92954 R180W Polymorphism NA 0.222 0.00 24 0.265 Q92954 I1272T Polymorphism 0.093 0.106 0.29 18 0.085 Q92954 N1130S Polymorphism 0.082 0.107 0.08 6 0.115 Q92956 K17R Polymorphism NA 0.109 0.10 0 0.110 Q92956 A117T Polymorphism 0.063 0.161 1.00 24 0.080 Q92956 G174E Polymorphism 0.652 0.490 0.06 51 0.653 Q92959 A396T Polymorphism 0.110 0.285 0.58 -59 0.147 Q92968 I326T Disease 0.341 0.559 0.02 35 0.650 Q92973 D34E Polymorphism NA 0.339 0.09 27 0.421 Q92985 Q412R Polymorphism 0.152 0.085 0.51 -8 0.103 Q92997 W433L Polymorphism 0.128 0.962 0.27 51 0.874 Q93033 L955F Polymorphism 0.361 0.453 0.00 33 0.618 Q93033 M415V Polymorphism 0.429 0.057 1.00 -19 0.019 Q93033 N225S Polymorphism 0.296 0.207 0.43 18 0.082 Q93033 S525R Polymorphism 0.431 0.707 0.18 10 0.531 Q93033 T631S Polymorphism 0.244 0.151 0.79 -43 0.115 Q93033 V965I Polymorphism NA 0.197 0.00 -47 0.201 Q93038 R370L Polymorphism 0.521 0.857 0.16 45 0.830 Q93038 R381H Polymorphism 0.611 0.130 0.09 29 0.335 Q93063 C85R Disease NA 0.963 0.00 28 0.813 Q93063 M42V Polymorphism NA 0.115 1.00 -15 0.033 Q93063 A202V Disease NA 0.091 0.56 21 0.125 Q93063 D227N Disease 0.927 0.886 0.00 52 0.945 Q93063 I380T Disease 0.535 0.538 0.02 17 0.544 Q93063 L152R Disease 0.735 0.954 0.00 60 0.937 Q93063 R179S Disease 0.184 0.169 0.40 12 0.233 Q93063 R223P Disease 0.730 0.975 0.03 50 0.907 Q93070 N265D Polymorphism 0.352 0.682 0.41 29 0.585 Q93074 R961W Disease 0.792 0.336 0.02 21 0.581 Q93074 N1007S Disease 0.284 0.121 0.41 -10 0.113 Q93074 Q1392R Polymorphism 0.186 0.115 0.72 1 0.200 Q93075 H217R Polymorphism NA 0.053 NA 13 0.034 Q93075 V256I Polymorphism NA 0.075 NA -10 0.044 Q93091 R89Q Polymorphism 0.184 0.066 0.77 17 0.084 Q93099 E42A Disease 0.697 0.934 0.00 57 0.916 Q93099 L25P Disease 0.252 0.962 0.00 28 0.720 Q93099 W60G Disease 0.752 0.892 0.00 61 0.907 Q93099 W97G Disease 0.747 0.904 0.00 59 0.910 Q93099 Y62C Disease 0.834 0.907 0.00 61 0.939 Q93099 A122D Disease 0.451 0.880 0.26 52 0.873 Q93099 D153G Disease 0.576 0.922 0.00 27 0.853 Q93099 D291E Disease 0.441 0.829 0.00 47 0.857 Q93099 E168K Disease 0.351 0.905 0.01 61 0.885 Q93099 F227S Disease 0.586 0.966 0.00 49 0.887 Q93099 G161R Disease 0.887 0.940 0.00 65 0.942 Q93099 G270R Disease 0.887 0.939 0.00 69 0.943 Q93099 H371R Disease 0.759 0.927 0.00 68 0.940 Q93099 I216T Disease 0.505 0.905 0.00 44 0.844 Q93099 M368V Disease 0.439 0.866 0.03 64 0.906 Q93099 P230S Disease 0.512 0.925 0.00 48 0.872 Q93099 P230T Disease 0.600 0.935 0.00 49 0.885 Q93099 R225H Disease 0.693 0.936 0.00 46 0.890 Q93099 R330S Disease 0.518 0.957 0.00 47 0.880 Q93099 S189I Disease 0.493 0.515 0.03 20 0.716 Q93099 V300G Disease 0.614 0.954 0.00 50 0.904 Q93100 A118P Disease 0.583 0.808 0.08 42 0.859 Q93100 Y770C Polymorphism 0.875 0.951 0.01 34 0.892 Q95365 V9L Polymorphism 0.206 0.265 1.00 -79 0.170 Q95365 A65T Polymorphism 0.254 0.312 0.09 -21 0.344 Q95365 C91F Polymorphism 0.375 0.588 0.66 -20 0.264 Q95365 C91S Polymorphism 0.486 0.183 0.41 -16 0.109 Q95365 E82G Polymorphism 0.726 0.820 0.00 11 0.807 Q95365 N87E Polymorphism 0.416 0.144 1.00 8 0.144 Q95365 V36M Polymorphism 0.403 0.253 0.24 12 0.358 Q95365 Y98D Polymorphism 0.197 0.518 0.59 25 0.337 Q95365 A329T Polymorphism 0.280 0.285 0.64 -24 0.330 Q95365 I104T Polymorphism 0.315 0.076 1.00 -32 0.074 Q95365 N101S Polymorphism 0.295 0.301 0.50 5 0.361 Q95365 T187M Polymorphism 0.688 0.350 0.25 26 0.621 Q95460 H39R Polymorphism 0.425 0.345 1.00 -10 0.133 Q95604 A73E Polymorphism 0.554 0.540 0.07 19 0.615 Q95604 A97T Polymorphism 0.412 0.071 1.00 -58 0.039 Q95604 V76M Polymorphism 0.313 0.146 0.51 -41 0.161 Q95604 V272M Polymorphism 0.800 0.420 0.05 5 0.570 Q969E4 Q87E Polymorphism NA 0.027 1.00 -11 0.068 Q969F2 T257K Polymorphism 0.756 0.646 0.00 47 0.821 Q969F8 C223R Disease 0.657 0.784 0.00 51 0.894 Q969F8 L102P Disease 0.721 0.516 0.08 26 0.665 Q969F8 L148S Disease 0.573 0.357 0.03 49 0.693 Q969F8 R297L Disease 0.402 0.557 1.00 22 0.328 Q969F8 R386P Disease NA 0.377 0.10 33 0.495 Q969F9 R397W Disease NA 0.645 NA 63 0.825 Q969G2 N328S Polymorphism 0.353 0.073 1.00 -12 0.067 Q969G5 A104T Polymorphism 0.308 0.124 0.32 6 0.221 Q969H0 E115K Polymorphism NA 0.093 0.05 44 0.061 Q969H0 R133G Polymorphism NA 0.089 0.02 40 0.126 Q969H0 S668G Polymorphism 0.361 0.182 0.45 3 0.290 Q969H0 T144R Polymorphism NA 0.075 0.02 53 0.112 Q969H4 R662W Polymorphism 0.825 0.078 0.03 -11 0.124 Q969H8 G12R Polymorphism NA 0.446 NA 45 0.321 Q969I6 G29R Polymorphism NA 0.089 0.42 15 0.079 Q969I6 T366M Polymorphism 0.692 0.056 0.33 -8 0.114 Q969J3 S41C Polymorphism NA 0.094 0.01 30 0.142 Q969J5 L16P Polymorphism 0.283 0.714 0.06 54 0.497 Q969J5 E190K Polymorphism 0.167 0.197 0.46 44 0.300 Q969K7 L110F Polymorphism NA 0.237 0.04 35 0.363 Q969N4 S153N Polymorphism 0.623 0.073 0.32 -5 0.170 Q969P5 G89A Polymorphism 0.251 0.194 0.49 -5 0.246 Q969P6 V256I Polymorphism 0.162 0.119 1.00 -27 0.096 Q969Q0 I66V Polymorphism 0.088 0.524 0.67 -19 0.183 Q969Q1 K237E Polymorphism 0.270 0.174 1.00 -32 0.103 Q969Q4 E164K Polymorphism 0.176 0.735 0.00 29 0.541 Q969Q4 L120M Polymorphism 0.431 0.748 0.02 0 0.196 Q969R5 I7V Polymorphism NA 0.062 NA -1 0.048 Q969S2 P304T Polymorphism 0.568 0.192 0.51 5 0.214 Q969S2 R103Q Polymorphism 0.136 0.015 0.04 11 0.030 Q969S8 V429I Polymorphism NA 0.139 0.27 29 0.143 Q969S9 E735G Polymorphism NA 0.817 0.01 48 0.730 Q969S9 R774Q Polymorphism NA 0.185 0.17 3 0.265 Q969S9 S300C Polymorphism NA 0.748 0.00 24 0.651 Q969T4 W201R Polymorphism 0.676 0.758 0.00 49 0.903 Q969V4 I146V Polymorphism NA 0.104 1.00 -42 0.074 Q969V4 V332I Polymorphism 0.088 0.067 0.52 -41 0.091 Q969V6 S648G Polymorphism 0.289 0.113 0.51 -8 0.110 Q969X1 P21L Polymorphism NA 0.135 0.58 24 0.232 Q969X6 R438H Polymorphism NA 0.070 0.17 26 0.119 Q969X6 R565W Disease NA 0.207 0.02 49 0.374 Q969Y0 T507I Polymorphism 0.214 0.337 0.21 -27 0.390 Q969Z0 A22S Polymorphism NA 0.320 0.14 28 0.240 Q969Z3 G244S Polymorphism 0.906 0.813 0.10 47 0.892 Q96A22 T23R Polymorphism NA 0.130 NA 41 0.037 Q96A26 A50V Polymorphism 0.152 0.090 0.14 6 0.110 Q96A28 V86M Polymorphism NA 0.225 0.07 28 0.370 Q96A28 D164H Polymorphism 0.751 0.368 0.07 25 0.625 Q96A28 E181K Polymorphism 0.124 0.494 0.86 22 0.393 Q96A29 I240V Polymorphism 0.643 0.115 0.28 -27 0.163 Q96A29 R147C Disease 0.996 0.978 0.00 56 0.966 Q96A29 T308R Disease 0.966 0.938 0.01 60 0.965 Q96A56 C75R Polymorphism NA 0.207 0.00 -3 0.194 Q96A70 A288S Polymorphism 0.633 0.859 0.02 37 0.718 Q96A83 P427L Polymorphism NA 0.187 NA 2 0.182 Q96A84 A107G Polymorphism 0.112 0.098 1.00 -23 0.063 Q96A99 R234Q Polymorphism 0.395 0.063 0.45 -10 0.053 Q96A99 R281K Polymorphism 0.237 0.203 1.00 -17 0.135 Q96AA3 R67C Disease 0.676 0.953 0.01 70 0.937 Q96AA3 A185T Polymorphism 0.263 0.519 0.03 47 0.606 Q96AB6 H283N Polymorphism 0.149 0.063 NA 1 0.027 Q96AC6 G67E Polymorphism NA 0.156 NA 40 0.203 Q96AD5 P195L Disease 0.962 0.761 0.00 14 0.886 Q96AE7 I145L Polymorphism NA 0.166 NA -39 0.113 Q96AE7 N270H Polymorphism NA 0.554 NA 48 0.738 Q96AH0 T154S Polymorphism 0.089 0.121 0.66 -28 0.087 Q96AJ1 R401W Polymorphism 0.220 0.083 0.01 36 0.130 Q96AN5 D143N Polymorphism 0.316 0.090 NA 19 0.096 Q96AP4 N379D Polymorphism NA 0.122 1.00 0 0.114 Q96AP7 R273C Polymorphism 0.820 0.696 0.01 58 0.768 Q96AQ2 A112D Polymorphism NA 0.555 NA 56 0.681 Q96AQ6 G357D Polymorphism 0.048 0.159 0.63 10 0.133 Q96AQ9 E226D Polymorphism NA 0.091 0.21 0 0.061 Q96AV8 M626V Polymorphism NA 0.061 1.00 1 0.041 Q96AX2 A188P Polymorphism NA 0.968 0.03 48 0.882 Q96AX9 F15L Polymorphism NA 0.101 NA 28 0.025 Q96AY2 I49V Polymorphism 0.070 0.094 0.86 14 0.052 Q96AY2 V347I Polymorphism 0.201 0.126 0.32 10 0.142 Q96B21 T59I Polymorphism 0.089 0.131 0.78 -32 0.075 Q96B33 V210M Polymorphism 0.330 0.064 0.08 26 0.071 Q96B36 A47P Polymorphism 0.169 0.255 NA 23 0.148 Q96B86 A431V Polymorphism NA 0.073 0.16 -49 0.045 Q96B96 G107S Polymorphism NA 0.248 0.13 -29 0.138 Q96B97 P382L Polymorphism 0.244 0.254 0.00 27 0.283 Q96BA8 A411T Polymorphism NA 0.050 0.25 -4 0.069 Q96BD5 R347H Polymorphism NA 0.257 0.02 22 0.340 Q96BH3 C100W Polymorphism 0.839 0.903 0.00 50 0.929 Q96BH3 D170N Polymorphism 0.257 0.584 0.10 23 0.450 Q96BH3 D215N Polymorphism 0.740 0.923 0.01 26 0.822 Q96BI1 A6T Polymorphism 0.098 0.078 0.06 17 0.045 Q96BI1 R12Q Polymorphism 0.087 0.028 0.78 -4 0.055 Q96BI1 R309Q Polymorphism 0.261 0.169 0.29 53 0.323 Q96BI1 S233F Disease 0.474 0.487 0.62 4 0.440 Q96BI1 W324C Polymorphism 0.384 0.233 0.03 17 0.401 Q96BK5 E315A Polymorphism 0.149 0.036 0.05 -3 0.024 Q96BK5 Q206H Polymorphism 0.344 0.049 0.13 29 0.067 Q96BN2 R198Q Polymorphism 0.454 0.325 0.00 48 0.597 Q96BN6 G571R Polymorphism NA 0.028 0.74 26 0.024 Q96BN8 M155L Polymorphism NA 0.050 NA -28 0.036 Q96BN8 S227N Polymorphism NA 0.169 NA -5 0.188 Q96BQ1 P60S Polymorphism 0.206 0.330 0.09 0 0.238 Q96BQ1 A118S Polymorphism 0.136 0.164 0.41 -35 0.104 Q96BQ5 R60H Polymorphism NA 0.045 0.42 -2 0.032 Q96BR1 L355P Polymorphism 0.815 0.727 0.00 57 0.906 Q96BR5 K219R Polymorphism 0.127 0.020 0.43 -33 0.057 Q96BR6 E76D Polymorphism NA 0.067 0.10 22 0.096 Q96BR9 G418A Polymorphism NA 0.165 0.09 -32 0.043 Q96BT3 P115L Polymorphism NA 0.212 0.00 9 0.243 Q96BW5 E97G Polymorphism 0.538 0.767 0.02 42 0.861 Q96BY7 N1124D Polymorphism NA 0.040 0.31 -12 0.017 Q96BY9 P78T Polymorphism 0.787 0.659 0.00 46 0.784 Q96BZ4 E27Q Polymorphism NA 0.093 0.34 -5 0.065 Q96BZ4 V135M Polymorphism NA 0.460 0.14 16 0.346 Q96BZ8 E97K Polymorphism 0.636 0.359 NA 18 0.589 Q96BZ9 N79S Polymorphism 0.139 0.170 0.74 11 0.128 Q96C10 R95Q Polymorphism 0.163 0.500 0.53 14 0.267 Q96C10 Q425R Polymorphism 0.296 0.151 0.39 -44 0.204 Q96C10 R523Q Polymorphism 0.228 0.081 0.65 -16 0.106 Q96C11 N43K Polymorphism NA 0.405 0.93 0 0.395 Q96C11 L246V Polymorphism 0.430 0.806 0.04 54 0.844 Q96C23 N190Y Polymorphism 0.544 0.549 0.88 -43 0.314 Q96C34 V4I Polymorphism NA 0.253 NA 5 0.168 Q96C34 E566K Polymorphism 0.079 0.347 0.00 31 0.245 Q96C34 L397M Polymorphism 0.064 0.136 NA -6 0.087 Q96C45 K39R Polymorphism 0.235 0.201 0.04 35 0.331 Q96C45 V18A Polymorphism NA 0.835 0.01 60 0.904 Q96C45 A542T Polymorphism 0.152 0.051 0.94 -47 0.022 Q96C45 A715T Polymorphism 0.138 0.112 0.94 -27 0.050 Q96C45 K569R Polymorphism 0.220 0.322 0.00 -19 0.241 Q96C45 N139K Polymorphism 0.580 0.803 0.01 57 0.844 Q96C45 S223N Polymorphism 0.164 0.250 0.37 35 0.256 Q96C45 A1261V Polymorphism NA 0.098 NA 3 0.023 Q96C74 A113V Polymorphism NA 0.056 0.05 5 0.109 Q96C86 G73E Polymorphism 0.096 0.550 0.00 7 0.404 Q96C92 E176G Polymorphism NA 0.173 0.25 27 0.152 Q96C92 L157V Polymorphism NA 0.214 0.05 3 0.369 Q96C92 V379M Polymorphism NA 0.200 0.11 12 0.321 Q96CA5 E223Q Polymorphism 0.174 0.104 0.61 -32 0.117 Q96CB9 T51A Polymorphism 0.086 0.145 0.46 0 0.166 Q96CB9 I325T Polymorphism 0.586 0.418 0.01 34 0.646 Q96CB9 I365V Polymorphism 0.132 0.116 0.64 -11 0.112 Q96CG3 T19M Polymorphism NA 0.214 0.01 49 0.254 Q96CM3 E155D Polymorphism 0.413 0.133 1.00 -19 0.123 Q96CM8 G75V Polymorphism 0.501 0.281 0.36 44 0.485 Q96CN9 R86W Polymorphism 0.822 0.054 NA 43 0.108 Q96CN9 A122V Polymorphism 0.341 0.085 0.00 9 0.116 Q96CN9 Q262R Polymorphism 0.285 0.095 0.09 -2 0.095 Q96CT7 E138Q Polymorphism 0.207 0.256 0.00 -16 0.256 Q96CU9 A343P Polymorphism 0.239 0.811 0.22 15 0.507 Q96CU9 H380R Polymorphism 0.352 0.560 0.31 18 0.459 Q96CU9 V145I Polymorphism 0.149 0.138 0.36 22 0.229 Q96CV9 E50K Disease NA 0.355 0.00 43 0.553 Q96CV9 H26D Disease NA 0.084 0.66 8 0.035 Q96CV9 M98K Polymorphism NA 0.083 1.00 -26 0.063 Q96CV9 E103D Disease NA 0.185 0.16 22 0.332 Q96CV9 H486R Disease NA 0.341 0.13 26 0.466 Q96CV9 P201S Polymorphism NA 0.146 0.29 7 0.133 Q96CV9 R545Q Disease NA 0.027 0.69 -23 0.047 Q96CV9 S308P Polymorphism NA 0.796 0.04 46 0.821 Q96CW5 T208S Polymorphism 0.064 0.102 0.39 -42 0.063 Q96CX3 M17V Polymorphism 0.382 0.295 0.01 23 0.408 Q96D09 R173S Polymorphism NA 0.298 0.50 22 0.450 Q96D15 R250W Polymorphism 0.856 0.255 0.03 37 0.595 Q96D31 R91W Disease NA 0.513 0.00 36 0.719 Q96D46 E6K Polymorphism NA 0.073 0.85 23 0.091 Q96D53 H174R Polymorphism 0.544 0.370 0.48 -54 0.219 Q96D53 T318M Polymorphism 0.962 0.520 0.03 34 0.795 Q96D53 T352R Polymorphism 0.741 0.231 0.57 -32 0.330 Q96D59 T82A Polymorphism 0.200 0.056 0.72 -25 0.061 Q96D59 R114Q Polymorphism 0.471 0.153 0.17 28 0.104 Q96DA0 M133V Polymorphism NA 0.124 0.08 4 0.120 Q96DC8 D162N Polymorphism 0.953 0.867 0.00 71 0.850 Q96DF8 A423V Polymorphism 0.431 0.114 0.55 -13 0.092 Q96DG6 Y155C Polymorphism 0.706 0.619 0.01 54 0.846 Q96DN0 F52L Polymorphism NA 0.567 1.00 0 0.408 Q96DN5 V709F Polymorphism NA 0.172 0.00 36 0.282 Q96DP5 V5A Polymorphism NA 0.094 0.24 6 0.047 Q96DR5 G43R Polymorphism NA 0.288 0.33 31 0.086 Q96DR5 R221C Polymorphism 0.640 0.114 0.05 38 0.193 Q96DR7 F203S Polymorphism NA 0.116 0.06 16 0.013 Q96DS6 I6V Polymorphism NA 0.020 NA -8 0.026 Q96DS6 T10A Polymorphism NA 0.211 NA 36 0.232 Q96DS6 V47F Polymorphism 0.579 0.403 0.14 47 0.380 Q96DT5 E34V Polymorphism NA 0.152 NA 21 0.126 Q96DT5 A3474T Polymorphism 0.071 0.263 0.61 -34 0.142 Q96DT5 D1640G Polymorphism NA 0.835 0.02 36 0.854 Q96DT5 I2682V Polymorphism 0.059 0.107 0.83 -49 0.078 Q96DT5 L3715V Polymorphism 0.165 0.129 1.00 -75 0.095 Q96DT5 M1316V Polymorphism NA 0.439 0.03 -4 0.206 Q96DT5 M4172V Polymorphism 0.055 0.437 0.75 4 0.126 Q96DT5 R3004Q Disease 0.862 0.715 0.12 40 0.730 Q96DT5 T4177I Polymorphism 0.303 0.228 0.15 -12 0.200 Q96DT5 V1023A Polymorphism NA 0.393 0.45 -35 0.249 Q96DU9 N314S Polymorphism 0.144 0.250 0.22 -35 0.144 Q96DW6 R66G Polymorphism 0.541 0.611 0.45 27 0.467 Q96DW6 D209H Disease 0.475 0.359 0.22 23 0.407 Q96DW6 G130E Disease 0.954 0.835 0.04 75 0.926 Q96DW6 R134H Disease 0.978 0.282 0.01 70 0.959 Q96DW6 R187P Disease 0.978 0.840 0.08 69 0.898 Q96DX8 T79I Polymorphism 0.274 0.214 0.07 5 0.311 Q96DY2 L136V Polymorphism NA 0.067 0.20 6 0.117 Q96DZ5 D175V Polymorphism 0.132 0.341 0.00 6 0.326 Q96DZ7 V162I Polymorphism NA 0.110 0.19 3 0.182 Q96E11 M216V Polymorphism 0.089 0.595 0.31 -9 0.060 Q96E22 N175Y Polymorphism 0.541 0.329 0.42 17 0.542 Q96E22 T219K Polymorphism 0.194 0.213 0.58 -31 0.172 Q96E52 N67K Polymorphism NA 0.382 0.00 61 0.458 Q96E52 I329L Polymorphism 0.327 0.865 0.48 -4 0.545 Q96E93 W58R Polymorphism 0.068 0.170 0.57 18 0.156 Q96EB6 V484D Polymorphism 0.430 0.562 0.67 -27 0.371 Q96ED9 G10R Polymorphism 0.376 0.244 0.39 16 0.414 Q96EE3 T342N Polymorphism NA 0.094 NA 15 0.065 Q96EG1 A11V Polymorphism NA 0.264 1.00 -77 0.200 Q96EG1 R385H Polymorphism 0.336 0.161 0.37 -32 0.187 Q96EG1 W274R Polymorphism 0.066 0.622 1.00 15 0.020 Q96EG3 Q153R Polymorphism NA 0.259 0.60 -7 0.212 Q96EK2 G127S Polymorphism NA 0.052 1.00 -30 0.031 Q96EK5 G66S Polymorphism 0.166 0.058 0.37 -40 0.017 Q96EK7 C511G Polymorphism NA 0.128 0.43 24 0.117 Q96EK7 D370Y Polymorphism 0.722 0.178 0.01 43 0.344 Q96EK7 M379T Polymorphism 0.402 0.156 0.65 19 0.141 Q96EK7 P433A Polymorphism 0.214 0.092 0.91 29 0.075 Q96EK7 Y428C Polymorphism 0.577 0.105 0.15 35 0.037 Q96EK7 Y440C Polymorphism 0.577 0.093 0.17 38 0.038 Q96EM0 V42A Polymorphism NA 0.239 0.24 -17 0.367 Q96EN8 A57P Disease NA 0.813 0.05 44 0.830 Q96EN8 H703N Polymorphism 0.370 0.575 0.37 -1 0.468 Q96EN8 R776C Disease 0.993 0.957 0.00 65 0.957 Q96EN8 S120N Polymorphism NA 0.500 0.06 49 0.751 Q96EN8 T294I Disease NA 0.893 0.00 45 0.836 Q96EN8 V541L Polymorphism NA 0.173 0.60 15 0.121 Q96ER3 S426G Polymorphism NA 0.056 0.03 38 0.117 Q96ER9 F360S Polymorphism NA 0.083 0.97 -4 0.021 Q96ES6 G292R Polymorphism 0.584 0.679 0.47 17 0.613 Q96EU7 D131E Polymorphism 0.059 0.067 0.43 -34 0.058 Q96EU7 E152K Disease 0.299 0.897 0.07 51 0.848 Q96EV8 P272S Polymorphism 0.134 0.230 0.09 8 0.189 Q96EW2 S64A Polymorphism 0.206 0.255 0.32 -22 0.211 Q96EY4 Q65P Polymorphism 0.177 0.250 0.20 -4 0.174 Q96EY5 C106Y Polymorphism NA 0.901 0.45 43 0.634 Q96EY8 I96T Disease 0.738 0.671 0.01 50 0.843 Q96EY8 A135T Disease 0.188 0.306 0.25 -15 0.258 Q96EY8 E193K Disease 0.833 0.892 0.00 70 0.937 Q96EY8 M239K Polymorphism 0.256 0.206 1.00 -15 0.130 Q96EY8 R191W Disease 0.974 0.938 0.00 60 0.949 Q96EZ4 G271R Polymorphism NA 0.453 NA 41 0.128 Q96F05 G97V Polymorphism NA 0.258 0.39 38 0.180 Q96F05 A150T Polymorphism NA 0.053 0.63 -39 0.014 Q96F10 R126C Polymorphism 0.710 0.707 0.01 10 0.830 Q96F25 V14M Polymorphism 0.397 0.164 0.09 11 0.173 Q96F46 P562Q Polymorphism NA 0.297 0.11 43 0.519 Q96F46 R580H Polymorphism NA 0.154 0.03 21 0.250 Q96F81 E103K Polymorphism NA 0.091 0.12 31 0.074 Q96FB5 V400L Polymorphism 0.421 0.092 0.29 -43 0.099 Q96FC9 C951R Polymorphism NA 0.443 NA 8 0.108 Q96FC9 Q567E Polymorphism NA 0.323 1.00 -20 0.180 Q96FC9 T575M Polymorphism NA 0.578 0.01 27 0.629 Q96FC9 W966C Polymorphism NA 0.216 NA 19 0.032 Q96FE5 S183F Polymorphism 0.159 0.538 0.05 51 0.765 Q96FE7 T251S Polymorphism NA 0.040 1.00 -44 0.010 Q96FG2 T70I Polymorphism NA 0.276 0.02 -12 0.399 Q96FI4 D252N Polymorphism 0.062 0.437 0.13 0 0.205 Q96FJ0 A210T Polymorphism NA 0.073 0.20 -33 0.112 Q96FJ0 E204K Polymorphism NA 0.112 0.27 -4 0.112 Q96FJ0 S196N Polymorphism NA 0.042 0.30 -16 0.108 Q96FL8 V338I Polymorphism 0.344 0.275 0.39 -8 0.292 Q96FL9 Q469K Polymorphism 0.517 0.211 0.39 28 0.455 Q96FN9 R6W Polymorphism 0.672 0.288 NA 50 0.474 Q96FQ7 P16A Polymorphism NA 0.188 NA 6 0.049 Q96FS4 S182F Polymorphism 0.888 0.236 0.00 28 0.569 Q96FV2 K103R Polymorphism 0.096 0.078 1.00 -10 0.081 Q96FX7 V66A Polymorphism 0.446 0.367 0.04 -18 0.362 Q96FX8 P143R Polymorphism 0.132 0.116 NA 34 0.097 Q96G03 E488D Polymorphism 0.404 0.376 0.57 -41 0.304 Q96G28 D243G Polymorphism 0.399 0.065 0.53 -4 0.067 Q96G46 D609N Polymorphism NA 0.656 1.00 1 0.427 Q96G91 A87T Polymorphism 0.297 0.181 0.13 -10 0.203 Q96G97 N88S Disease 0.266 0.316 0.00 30 0.243 Q96G97 S90L Disease 0.483 0.420 0.00 22 0.462 Q96G97 A212P Disease 0.765 0.908 0.00 51 0.920 Q96GD4 A52V Polymorphism NA 0.284 0.29 10 0.307 Q96GD4 H100Q Polymorphism NA 0.381 0.27 -4 0.187 Q96GD4 T179M Polymorphism 0.510 0.315 0.20 -19 0.546 Q96GE4 M165I Polymorphism 0.104 0.048 0.50 -39 0.012 Q96GE6 T154K Polymorphism 0.078 0.719 0.78 18 0.184 Q96GE9 P28T Polymorphism NA 0.105 NA -29 0.092 Q96GN5 R187S Polymorphism NA 0.296 0.00 -6 0.262 Q96GP6 A833G Polymorphism NA 0.060 0.26 12 0.034 Q96GP6 H517L Polymorphism 0.213 0.248 0.17 28 0.360 Q96GP6 P174S Polymorphism 0.643 0.225 0.42 10 0.577 Q96GP6 T425S Polymorphism 0.064 0.101 0.85 -26 0.082 Q96GQ5 Y185C Polymorphism 0.096 0.363 0.01 34 0.220 Q96GR2 A673V Polymorphism 0.209 0.255 1.00 -42 0.195 Q96GR4 P69S Polymorphism 0.981 0.927 0.00 33 0.945 Q96GX5 D606Y Polymorphism NA 0.192 NA 45 0.354 Q96GX5 E167D Disease 0.129 0.311 0.39 -8 0.172 Q96GX9 M181V Polymorphism 0.183 0.332 0.25 39 0.269 Q96GY3 P172S Polymorphism NA 0.067 NA -2 0.076 Q96H22 E288K Polymorphism NA 0.081 1.00 -6 0.059 Q96H55 L475I Polymorphism 0.528 0.709 0.02 29 0.618 Q96H55 N176S Polymorphism 0.731 0.917 0.17 41 0.622 Q96H55 Q203H Polymorphism 0.716 0.216 0.64 10 0.427 Q96H72 P346L Polymorphism 0.602 0.473 0.22 8 0.541 Q96H78 S52I Polymorphism 0.045 0.531 0.26 7 0.193 Q96H86 A332V Polymorphism 0.099 0.251 0.36 7 0.161 Q96H96 Y247C Disease 0.957 0.953 0.00 50 0.936 Q96HA1 A1215G Polymorphism 0.113 0.060 1.00 -37 0.009 Q96HA8 I32V Polymorphism 0.190 0.143 0.89 -16 0.078 Q96HA8 N93S Polymorphism 0.310 0.044 1.00 -21 0.023 Q96HA9 C91W Polymorphism 0.159 0.211 0.02 6 0.171 Q96HC4 P388S Polymorphism 0.044 0.348 0.53 25 0.215 Q96HC4 S319L Polymorphism NA 0.266 0.32 16 0.356 Q96HD1 P128R Polymorphism NA 0.605 0.01 3 0.533 Q96HD9 R8Q Polymorphism 0.241 0.056 0.19 -18 0.034 Q96HD9 V281M Polymorphism 0.407 0.362 0.01 26 0.425 Q96HF1 A45V Polymorphism NA 0.067 0.11 -11 0.112 Q96HI0 N83S Polymorphism NA 0.066 0.37 21 0.026 Q96HJ3 P53S Polymorphism 0.280 0.122 NA -5 0.092 Q96HJ3 I319V Polymorphism NA 0.188 NA 5 0.215 Q96HJ9 S8A Polymorphism NA 0.043 0.60 9 0.019 Q96HP0 P250L Polymorphism 0.534 0.492 0.40 8 0.695 Q96HP0 P555L Polymorphism 0.752 0.948 1.00 -25 0.818 Q96HP0 R826C Polymorphism 0.362 0.383 0.03 26 0.513 Q96HP4 R59Q Polymorphism NA 0.751 0.34 38 0.765 Q96HP4 R82C Polymorphism NA 0.430 0.12 38 0.513 Q96HP4 S64A Polymorphism NA 0.178 0.20 -25 0.110 Q96HP8 L187F Polymorphism 0.734 0.117 0.00 44 0.484 Q96HP8 T208A Polymorphism 0.109 0.070 0.55 -17 0.044 Q96HQ0 E141Q Polymorphism 0.105 0.677 0.34 -28 0.149 Q96HR8 P43S Polymorphism NA 0.100 0.00 1 0.079 Q96HY7 N350D Polymorphism 0.217 0.687 0.92 -12 0.263 Q96HY7 Y272D Polymorphism NA 0.699 0.66 2 0.374 Q96HZ4 R218Q Polymorphism 0.049 0.037 0.56 12 0.041 Q96I15 K52E Polymorphism 0.407 0.602 0.93 -18 0.379 Q96I15 A175T Polymorphism 0.542 0.361 0.00 23 0.481 Q96I15 F276S Polymorphism 0.266 0.511 0.39 5 0.369 Q96I51 R30G Polymorphism NA 0.312 0.52 21 0.204 Q96I76 N234S Polymorphism 0.223 0.161 NA -12 0.125 Q96I82 C76G Polymorphism 0.224 0.967 0.21 34 0.599 Q96ID5 T379M Polymorphism NA 0.441 0.08 49 0.568 Q96II8 P522L Polymorphism NA 0.209 0.00 40 0.409 Q96IJ6 S21F Polymorphism 0.951 0.435 0.00 45 0.776 Q96IQ9 Q65R Polymorphism 0.111 0.103 0.05 48 0.088 Q96IS3 R87Q Disease 0.403 0.341 0.27 36 0.398 Q96IS3 G137R Disease 0.335 0.322 0.60 43 0.447 Q96IW2 G138S Polymorphism 0.069 0.348 0.50 -2 0.195 Q96IW2 N270S Polymorphism 0.076 0.050 0.68 -6 0.043 Q96IZ0 G137A Polymorphism 0.238 0.031 NA -10 0.101 Q96IZ5 H376Y Polymorphism 0.156 0.215 0.07 0 0.114 Q96J65 A102E Polymorphism NA 0.229 1.00 -37 0.252 Q96J65 K894M Polymorphism 0.287 0.407 0.01 17 0.538 Q96J65 N587Y Polymorphism 0.373 0.285 0.75 -14 0.429 Q96J65 T989S Polymorphism 0.063 0.038 1.00 -30 0.029 Q96J65 E1191A Polymorphism 0.504 0.172 0.60 1 0.208 Q96J65 R1117C Polymorphism 0.097 0.169 0.05 7 0.201 Q96J65 Y1013H Polymorphism 0.126 0.306 0.58 -8 0.168 Q96J66 R19H Polymorphism NA 0.090 NA 39 0.077 Q96J66 A317E Polymorphism 0.084 0.795 1.00 8 0.218 Q96J66 G180R Polymorphism 0.920 0.876 0.34 20 0.888 Q96J66 V648I Polymorphism 0.294 0.533 0.33 -24 0.246 Q96J66 V687I Polymorphism 0.294 0.237 1.00 -22 0.234 Q96J86 R95H Polymorphism NA 0.543 0.00 57 0.730 Q96J86 P111S Polymorphism NA 0.209 0.44 4 0.167 Q96J92 D564A Disease 0.229 0.461 0.00 34 0.531 Q96J92 E562K Disease 0.258 0.592 0.01 29 0.654 Q96J92 P813L Polymorphism 0.112 0.129 0.01 -12 0.183 Q96J92 Q565E Disease 0.193 0.391 0.02 30 0.511 Q96J92 R1185C Disease 0.947 0.469 0.00 61 0.898 Q96J94 K491N Polymorphism 0.192 0.266 0.52 25 0.288 Q96J94 R527K Polymorphism 0.113 0.493 0.96 -2 0.087 Q96JA1 L24V Polymorphism NA 0.272 0.06 -37 0.229 Q96JA1 G993A Polymorphism NA 0.180 0.91 17 0.116 Q96JA1 Q1053P Polymorphism NA 0.364 0.02 39 0.335 Q96JB1 A727T Polymorphism NA 0.315 0.38 27 0.346 Q96JB1 I573V Polymorphism NA 0.111 0.33 -51 0.176 Q96JB1 I4271V Polymorphism 0.085 0.081 1.00 -37 0.053 Q96JB1 T2444N Polymorphism 0.229 0.420 0.27 -22 0.310 Q96JB1 T4106M Polymorphism 0.763 0.214 0.01 9 0.485 Q96JB5 L324V Polymorphism 0.113 0.040 1.00 -33 0.056 Q96JB6 D405A Polymorphism 0.701 0.532 0.07 54 0.655 Q96JB8 V562I Polymorphism NA 0.158 0.55 -42 0.130 Q96JD6 K86R Polymorphism 0.342 0.148 0.55 -19 0.152 Q96JE7 G730R Polymorphism 0.217 0.113 0.43 0 0.083 Q96JE7 H292R Polymorphism 0.243 0.161 0.35 20 0.122 Q96JE9 I247M Polymorphism 0.095 0.093 0.24 -49 0.017 Q96JG9 H2848R Polymorphism NA 0.033 NA -5 0.009 Q96JG9 K1162E Polymorphism NA 0.091 NA 14 0.045 Q96JG9 L2670Q Polymorphism NA 0.099 NA 25 0.022 Q96JG9 P1420L Polymorphism NA 0.018 NA -46 0.006 Q96JG9 R2129K Polymorphism NA 0.117 NA 7 0.105 Q96JG9 T3636A Polymorphism 0.216 0.064 NA 22 0.015 Q96JH8 D239N Polymorphism NA 0.052 0.52 24 0.140 Q96JI7 Y396C Polymorphism 0.413 0.182 NA -2 0.124 Q96JI7 F1349I Disease 0.263 0.624 NA 38 0.431 Q96JJ7 P61S Polymorphism 0.895 0.426 0.04 52 0.736 Q96JL9 A537V Polymorphism 0.129 0.173 0.13 2 0.134 Q96JM2 P1187S Polymorphism NA 0.174 0.00 -5 0.163 Q96JM3 P604R Polymorphism NA 0.107 0.02 48 0.134 Q96JM4 C83Y Polymorphism NA 0.346 0.00 37 0.208 Q96JM4 I29N Polymorphism NA 0.115 0.00 18 0.162 Q96JM4 A912T Polymorphism NA 0.036 0.02 15 0.051 Q96JM7 T183N Polymorphism NA 0.106 0.02 -2 0.168 Q96JN2 D218H Polymorphism NA 0.154 0.10 36 0.166 Q96JP5 V37I Polymorphism NA 0.095 NA 11 0.044 Q96JP5 S207G Polymorphism NA 0.139 0.20 42 0.133 Q96JP9 H53Q Polymorphism 0.133 0.182 0.44 7 0.194 Q96JP9 A243V Polymorphism 0.322 0.317 0.10 -18 0.305 Q96JQ2 P963L Polymorphism NA 0.169 NA 25 0.153 Q96JS3 H806D Polymorphism NA 0.184 0.00 28 0.053 Q96JS3 I678V Polymorphism NA 0.154 0.00 -21 0.042 Q96JS3 M592I Polymorphism NA 0.089 0.02 16 0.123 Q96JS3 P256L Polymorphism NA 0.110 0.11 0 0.113 Q96JS3 Q248E Polymorphism NA 0.207 0.48 19 0.290 Q96JY0 S41A Polymorphism 0.061 0.035 0.84 -51 0.016 Q96K12 F326S Polymorphism 0.397 0.495 0.01 -1 0.480 Q96K21 R210H Polymorphism NA 0.034 0.08 -58 0.086 Q96K58 A447V Polymorphism NA 0.569 0.21 19 0.585 Q96K58 G304E Polymorphism 0.226 0.222 0.07 45 0.368 Q96K78 R756H Polymorphism 0.585 0.177 0.54 6 0.134 Q96KA5 T537M Polymorphism NA 0.061 0.09 -9 0.088 Q96KB5 E220D Polymorphism 0.244 0.098 0.62 -4 0.161 Q96KB5 M241L Polymorphism 0.122 0.218 1.00 -22 0.146 Q96KB5 N107S Polymorphism 0.402 0.114 0.66 -18 0.146 Q96KD3 E242K Polymorphism 0.371 0.176 0.10 35 0.196 Q96KD3 S228L Polymorphism 0.319 0.060 0.12 -1 0.096 Q96KG7 P897L Polymorphism NA 0.274 0.01 25 0.340 Q96KG9 P479L Polymorphism 0.373 0.687 0.01 31 0.744 Q96KG9 W755S Polymorphism 0.195 0.367 0.00 25 0.324 Q96KJ4 D463V Polymorphism 0.863 0.173 0.02 42 0.446 Q96KJ4 S597G Polymorphism 0.227 0.082 0.30 28 0.083 Q96KK4 F60L Polymorphism 0.147 0.907 0.01 -4 0.449 Q96KK4 P57S Polymorphism 0.951 0.914 0.00 52 0.885 Q96KK4 L255I Polymorphism 0.074 0.188 1.00 -54 0.122 Q96KK4 M100V Polymorphism 0.294 0.789 0.12 22 0.583 Q96KK4 M310R Polymorphism 0.047 0.255 0.26 0 0.225 Q96KK4 P160S Polymorphism 0.102 0.158 0.90 -32 0.099 Q96KK4 P174Q Polymorphism 0.216 0.416 0.05 11 0.201 Q96KK4 R121C Polymorphism 0.516 0.909 0.00 65 0.912 Q96KK4 R138W Polymorphism 0.685 0.861 0.21 21 0.758 Q96KN3 E110K Polymorphism 0.243 0.332 0.11 -1 0.342 Q96KN7 P96Q Polymorphism 0.119 0.034 0.60 6 0.023 Q96KN7 A547S Disease 0.364 0.233 0.42 -15 0.229 Q96KN7 A960P Polymorphism 0.521 0.134 0.03 4 0.124 Q96KN7 G746E Disease 0.845 0.952 0.04 63 0.948 Q96KN7 R827L Disease 0.575 0.698 0.02 46 0.829 Q96KN7 D1114G Disease 0.520 0.244 0.47 -5 0.415 Q96KN7 G1240E Polymorphism 0.845 0.601 0.00 37 0.748 Q96KN8 Q214R Polymorphism 0.302 0.445 0.43 -30 0.274 Q96KP1 N195T Polymorphism 0.231 0.072 0.49 -2 0.047 Q96KP4 Y126H Polymorphism 0.793 0.890 0.44 70 0.851 Q96KQ7 T55N Polymorphism NA 0.080 NA 8 0.039 Q96KR6 P126S Polymorphism 0.173 0.049 0.19 27 0.042 Q96KR7 P154L Polymorphism 0.559 0.134 0.17 1 0.220 Q96KT7 L307P Polymorphism 0.079 0.352 0.16 11 0.032 Q96KV6 G79D Polymorphism 0.140 0.544 1.00 -7 0.246 Q96KV6 N300S Polymorphism 0.178 0.225 0.17 -16 0.170 Q96KV7 P250L Polymorphism NA 0.079 NA 12 0.100 Q96KV7 S165T Polymorphism NA 0.239 NA 1 0.253 Q96KV7 V537A Polymorphism NA 0.174 0.90 22 0.134 Q96KW9 V111D Polymorphism NA 0.161 NA 26 0.013 Q96L03 N16S Polymorphism 0.159 0.047 0.72 -21 0.026 Q96L08 K136E Polymorphism NA 0.060 NA 3 0.031 Q96L12 D248G Polymorphism 0.419 0.948 0.02 42 0.859 Q96L12 V274I Polymorphism 0.153 0.057 0.47 -29 0.090 Q96L34 R377Q Polymorphism 0.222 0.182 0.49 4 0.144 Q96L42 E984Q Polymorphism 0.303 0.252 0.23 -3 0.193 Q96L50 I96N Polymorphism NA 0.129 0.13 -13 0.059 Q96L50 R229W Polymorphism 0.186 0.162 0.00 -9 0.270 Q96L73 V614L Polymorphism NA 0.137 NA 47 0.044 Q96L73 A1036P Polymorphism NA 0.258 NA 59 0.310 Q96L73 C1674W Disease 0.672 0.952 0.00 50 0.895 Q96L73 C1925R Disease 0.703 0.916 0.00 76 0.934 Q96L73 C2183S Disease 0.235 0.957 0.00 54 0.885 Q96L73 G1792V Disease 0.402 0.679 0.00 43 0.656 Q96L73 G1955D Disease 0.986 0.894 0.00 68 0.943 Q96L73 H1616L Disease 0.209 0.798 0.01 59 0.857 Q96L73 H2143Q Disease 0.240 0.748 0.00 69 0.858 Q96L73 I1687N Disease 0.124 0.714 0.00 39 0.656 Q96L73 L1091I Polymorphism NA 0.083 NA 26 0.058 Q96L73 L1637P Disease 0.648 0.791 0.00 21 0.831 Q96L73 R1984Q Disease 0.971 0.857 0.00 52 0.907 Q96L73 R2005Q Disease 0.260 0.266 0.01 25 0.301 Q96L73 R2017Q Disease 0.968 0.903 0.00 62 0.938 Q96L73 R2017W Disease 0.993 0.898 0.00 68 0.944 Q96L73 Y1997C Disease 0.819 0.881 0.00 55 0.920 Q96L91 T1308I Polymorphism 0.367 0.191 0.35 37 0.172 Q96L93 G810R Polymorphism NA 0.116 0.23 -24 0.119 Q96L93 R824S Polymorphism NA 0.276 0.21 22 0.218 Q96L93 N1119S Polymorphism NA 0.146 NA -39 0.088 Q96L96 E929D Polymorphism NA 0.021 0.16 15 0.047 Q96L96 Q602R Polymorphism NA 0.082 0.46 25 0.051 Q96L96 R336H Polymorphism NA 0.219 0.07 26 0.260 Q96L96 R836L Polymorphism NA 0.153 0.27 34 0.128 Q96L96 T414S Polymorphism NA 0.067 0.03 35 0.074 Q96L96 T761M Polymorphism NA 0.026 0.01 36 0.027 Q96L96 A1137G Polymorphism NA 0.196 0.05 14 0.171 Q96L96 A1873V Polymorphism NA 0.044 NA 12 0.079 Q96L96 R1412W Polymorphism NA 0.184 0.02 28 0.255 Q96LA6 V124M Polymorphism 0.652 0.390 0.08 57 0.713 Q96LA9 F8L Polymorphism NA 0.060 0.80 -21 0.039 Q96LA9 N25K Polymorphism NA 0.145 0.96 -27 0.111 Q96LA9 Y54C Polymorphism NA 0.707 0.15 19 0.558 Q96LA9 A182V Polymorphism 0.559 0.317 0.61 -3 0.583 Q96LB0 C82R Polymorphism NA 0.420 0.35 47 0.307 Q96LB1 F78L Polymorphism NA 0.774 0.02 17 0.598 Q96LB1 N16H Polymorphism NA 0.425 0.03 58 0.580 Q96LB1 N62S Polymorphism NA 0.487 0.14 31 0.445 Q96LB1 V43I Polymorphism NA 0.435 0.35 2 0.347 Q96LB2 I36V Polymorphism NA 0.214 0.14 9 0.309 Q96LB3 I55M Polymorphism NA 0.161 0.09 -31 0.083 Q96LB3 N355T Polymorphism NA 0.054 0.50 -6 0.074 Q96LB8 I13L Polymorphism NA 0.069 0.73 -75 0.010 Q96LB8 Q92R Polymorphism NA 0.175 0.32 7 0.199 Q96LB8 D301N Polymorphism 0.221 0.200 1.00 -2 0.104 Q96LB8 G192V Polymorphism NA 0.553 0.23 22 0.466 Q96LD8 T207A Polymorphism NA 0.063 0.93 -34 0.032 Q96LI9 R187H Polymorphism NA 0.083 NA 24 0.095 Q96LJ7 T241I Polymorphism NA 0.176 0.22 14 0.294 Q96LL9 F167L Polymorphism 0.159 0.477 0.00 38 0.560 Q96LM5 G93E Polymorphism NA 0.054 NA -8 0.010 Q96LM9 K141E Polymorphism NA 0.049 NA 16 0.025 Q96LP2 A187V Polymorphism 0.460 0.068 0.00 -26 0.103 Q96LP2 R150G Polymorphism 0.078 0.174 0.48 8 0.101 Q96LP6 P182R Polymorphism NA 0.098 NA 23 0.078 Q96LQ0 T83I Polymorphism 0.142 0.113 NA -1 0.012 Q96LS8 P90L Polymorphism NA 0.142 NA 41 0.069 Q96LT6 L146F Polymorphism NA 0.071 0.32 -20 0.072 Q96LW4 T505K Polymorphism NA 0.068 0.11 6 0.073 Q96LW9 K205R Polymorphism 0.075 0.091 0.26 -11 0.108 Q96LW9 R222Q Polymorphism 0.365 0.255 0.88 12 0.349 Q96LX8 T30S Polymorphism 0.244 0.102 0.32 -47 0.185 Q96LY2 R346H Polymorphism NA 0.253 NA -45 0.172 Q96LZ2 F50S Polymorphism NA 0.109 0.17 -25 0.125 Q96LZ7 G259D Polymorphism NA 0.622 0.07 32 0.529 Q96M02 M57I Polymorphism 0.260 0.126 NA -4 0.110 Q96M02 D531E Polymorphism 0.241 0.043 NA -18 0.041 Q96M11 D211G Disease NA 0.486 0.00 49 0.692 Q96M20 R37H Polymorphism 0.628 0.589 0.00 39 0.734 Q96M29 A59T Polymorphism NA 0.138 0.03 -38 0.193 Q96M29 H196R Polymorphism NA 0.250 0.35 11 0.308 Q96M29 M239T Polymorphism NA 0.316 0.01 34 0.510 Q96M29 Q315R Polymorphism 0.103 0.046 0.55 -6 0.086 Q96M32 R102Q Polymorphism NA 0.123 NA 3 0.131 Q96M34 D99G Polymorphism 0.353 0.320 0.34 20 0.218 Q96M34 N45T Polymorphism 0.309 0.115 0.63 24 0.101 Q96M63 P468L Polymorphism 0.518 0.157 0.45 -9 0.170 Q96M66 R171S Polymorphism NA 0.091 NA 29 0.058 Q96M69 A661V Polymorphism 0.097 0.063 1.00 -39 0.026 Q96M69 D302Y Polymorphism 0.668 0.355 0.01 4 0.581 Q96M83 K449T Polymorphism 0.072 0.036 0.15 16 0.039 Q96M95 T51P Polymorphism NA 0.150 0.27 25 0.247 Q96M96 M298T Disease 0.864 0.768 0.22 34 0.841 Q96MA6 I5T Polymorphism NA 0.091 1.00 -45 0.018 Q96MC2 K357E Polymorphism 0.204 0.124 0.72 -13 0.096 Q96MC2 S702I Polymorphism 0.434 0.098 0.11 -9 0.186 Q96MC2 V633F Polymorphism 0.756 0.225 0.01 11 0.555 Q96MC2 V734M Polymorphism NA 0.041 0.20 -4 0.106 Q96MC9 G213A Polymorphism NA 0.273 NA 9 0.082 Q96MC9 P233S Polymorphism NA 0.117 NA 5 0.053 Q96MC9 T259M Polymorphism NA 0.207 NA 21 0.033 Q96MF6 P79H Polymorphism 0.377 0.207 0.07 21 0.369 Q96MF7 V66A Polymorphism 0.389 0.075 0.05 5 0.100 Q96MG2 R233Q Polymorphism 0.418 0.192 0.19 28 0.189 Q96MI9 P417L Polymorphism NA 0.080 0.20 -59 0.030 Q96MK2 L580P Polymorphism 0.680 0.573 0.14 -6 0.284 Q96MN2 A144T Polymorphism 0.185 0.134 1.00 -56 0.096 Q96MN2 E383D Polymorphism 0.147 0.119 0.64 -6 0.116 Q96MN2 L774M Polymorphism 0.350 0.737 0.00 14 0.494 Q96MN2 P390Q Polymorphism 0.210 0.270 0.28 -41 0.264 Q96MN2 Q925L Polymorphism 0.098 0.734 0.15 -11 0.158 Q96MN2 R708H Polymorphism 0.139 0.664 1.00 -27 0.162 Q96MN9 P249S Polymorphism NA 0.120 0.20 -9 0.099 Q96MR6 C345S Polymorphism 0.362 0.212 0.09 33 0.305 Q96MR6 N241D Polymorphism NA 0.089 0.05 39 0.109 Q96MS0 L5P Disease NA 0.456 0.00 -23 0.522 Q96MS0 I66L Disease NA 0.591 0.28 7 0.306 Q96MS0 E319K Disease 0.289 0.153 0.30 43 0.379 Q96MS0 G361E Disease 0.718 0.552 0.02 22 0.606 Q96MS0 R416H Polymorphism 0.726 0.395 0.13 14 0.512 Q96MS0 R703P Disease 0.627 0.898 0.12 53 0.805 Q96MS0 S705P Disease 0.392 0.719 0.21 32 0.474 Q96MT3 R104Q Disease 0.456 0.791 0.01 50 0.728 Q96MT4 I2F Polymorphism NA 0.267 NA 6 0.047 Q96MT4 P43S Polymorphism NA 0.110 NA 29 0.062 Q96MT8 S651L Polymorphism NA 0.107 0.30 -11 0.043 Q96MX3 Q21R Polymorphism 0.090 0.077 0.58 11 0.041 Q96MX6 M241V Polymorphism NA 0.301 0.63 28 0.293 Q96MY7 G11A Polymorphism NA 0.114 NA -40 0.106 Q96MZ4 H54R Polymorphism NA 0.079 NA 4 0.039 Q96N16 K251R Polymorphism 0.112 0.133 0.49 -29 0.102 Q96N23 T558A Polymorphism NA 0.040 NA -34 0.030 Q96N38 I473V Polymorphism 0.429 0.394 0.03 42 0.493 Q96N38 I474V Polymorphism 0.456 0.440 0.32 1 0.317 Q96N66 F261L Polymorphism 0.114 0.177 0.90 -17 0.116 Q96N76 R188W Polymorphism NA 0.312 1.00 -32 0.160 Q96N76 S311T Polymorphism NA 0.852 0.00 51 0.887 Q96N77 Q363P Polymorphism NA 0.416 0.03 75 0.725 Q96N77 S231C Polymorphism 0.098 0.460 0.03 -48 0.281 Q96N87 A4D Polymorphism 0.045 0.542 0.05 8 0.170 Q96N87 C12S Polymorphism 0.227 0.271 0.73 -21 0.164 Q96N95 H211L Polymorphism 0.442 0.408 0.33 45 0.425 Q96N96 R20W Polymorphism NA 0.213 0.00 52 0.129 Q96NA2 A81T Polymorphism NA 0.164 0.46 23 0.158 Q96NA2 R281Q Polymorphism 0.275 0.500 0.22 38 0.664 Q96NA8 F18L Polymorphism NA 0.246 1.00 42 0.156 Q96NA8 R55P Polymorphism NA 0.050 0.39 43 0.034 Q96NB3 F135L Polymorphism 0.112 0.298 0.71 11 0.135 Q96NB3 S154T Polymorphism 0.117 0.041 0.59 0 0.032 Q96NF6 I81V Polymorphism 0.106 0.073 NA 5 0.070 Q96NF6 R26G Polymorphism 0.134 0.238 NA 18 0.100 Q96NG3 A18G Polymorphism 0.486 0.539 0.03 33 0.735 Q96NH3 R82Q Polymorphism NA 0.066 NA -2 0.019 Q96NH3 I280V Polymorphism NA 0.037 NA -31 0.072 Q96NL0 L47M Polymorphism NA 0.889 0.00 22 0.839 Q96NL0 E206G Polymorphism 0.170 0.938 0.10 38 0.540 Q96NL8 P19A Polymorphism NA 0.072 0.37 -12 0.045 Q96NR8 I51N Disease 0.987 0.940 0.00 65 0.945 Q96NR8 L99I Disease 0.674 0.750 0.00 51 0.800 Q96NR8 T49M Disease 0.815 0.773 0.01 53 0.903 Q96NR8 H151D Disease 0.915 0.779 0.03 71 0.823 Q96NR8 H151N Disease 0.923 0.750 0.03 60 0.828 Q96NR8 P230A Disease 0.993 0.808 0.00 66 0.927 Q96NR8 R161Q Polymorphism 0.319 0.252 0.60 -5 0.313 Q96NR8 S175P Disease 0.961 0.880 0.00 69 0.816 Q96NR8 Y226C Disease 0.928 0.747 0.18 23 0.831 Q96NT5 G147R Disease 0.806 0.721 0.01 55 0.902 Q96NT5 P425R Disease 0.519 0.208 0.10 11 0.430 Q96NT5 R113C Disease 0.956 0.962 0.00 73 0.954 Q96NT5 R113S Disease 0.843 0.913 0.00 66 0.937 Q96NT5 R376W Disease 0.986 0.822 0.00 45 0.923 Q96NT5 S318R Disease 0.817 0.760 0.00 20 0.849 Q96NT5 T295A Polymorphism 0.212 0.127 0.85 -21 0.122 Q96NU7 P360H Polymorphism 0.473 0.637 0.08 35 0.585 Q96NW7 H1054Y Polymorphism NA 0.073 0.19 0 0.057 Q96NX5 E259Q Polymorphism 0.263 0.073 0.48 -55 0.135 Q96NX5 V329I Polymorphism 0.041 0.148 0.19 -1 0.133 Q96NY8 F53L Polymorphism 0.233 0.167 0.58 -3 0.095 Q96NY9 Q481H Polymorphism 0.811 0.523 0.11 25 0.739 Q96NY9 R180P Polymorphism 0.173 0.583 0.10 29 0.638 Q96NY9 R350W Polymorphism 0.935 0.368 0.01 38 0.655 Q96P09 A225T Polymorphism 0.132 0.221 0.61 -20 0.188 Q96P09 A225V Polymorphism 0.096 0.272 0.11 18 0.208 Q96P11 P183S Polymorphism NA 0.590 0.54 11 0.433 Q96P15 I181T Polymorphism 0.126 0.338 0.14 -25 0.021 Q96P15 I354T Polymorphism 0.476 0.270 0.10 28 0.401 Q96P31 N28D Polymorphism NA 0.286 0.83 -18 0.202 Q96P31 N721S Polymorphism NA 0.186 NA 28 0.062 Q96P31 P660L Polymorphism NA 0.141 0.24 1 0.073 Q96P44 G560S Polymorphism 0.998 0.481 0.06 62 0.944 Q96P44 L277P Polymorphism NA 0.940 0.00 -28 0.569 Q96P44 T343M Polymorphism 0.129 0.236 0.08 27 0.306 Q96P48 R358Q Polymorphism NA 0.207 0.30 47 0.364 Q96P63 K227E Polymorphism 0.338 0.672 0.62 -16 0.377 Q96P63 N289T Polymorphism 0.407 0.483 0.20 -7 0.396 Q96P66 L376P Polymorphism NA 0.462 0.35 21 0.397 Q96P66 V124L Polymorphism 0.166 0.722 0.14 -20 0.265 Q96P69 R342H Polymorphism 0.536 0.128 0.21 31 0.032 Q96PC2 R60W Polymorphism NA 0.122 0.02 20 0.275 Q96PC2 A308V Polymorphism 0.206 0.180 0.27 -7 0.228 Q96PC2 V312I Polymorphism 0.336 0.160 0.38 -23 0.221 Q96PD2 D723N Polymorphism 0.473 0.242 0.48 27 0.235 Q96PD4 E126G Polymorphism 0.648 0.405 0.05 36 0.621 Q96PD4 H161R Polymorphism NA 0.355 0.04 36 0.280 Q96PD4 V155I Polymorphism 0.447 0.355 0.14 47 0.435 Q96PD5 M270K Polymorphism NA 0.356 0.00 48 0.585 Q96PD5 R394Q Polymorphism NA 0.733 0.10 6 0.530 Q96PD5 T257N Polymorphism NA 0.145 0.02 -15 0.101 Q96PD7 M361I Polymorphism 0.195 0.302 0.30 -26 0.150 Q96PD7 R317G Polymorphism 0.867 0.965 0.03 52 0.943 Q96PE2 G450E Polymorphism NA 0.156 0.00 44 0.053 Q96PE2 A1465D Polymorphism 0.394 0.223 0.02 46 0.378 Q96PE3 T604A Polymorphism NA 0.051 0.09 11 0.033 Q96PE6 R7K Polymorphism NA 0.330 0.30 -19 0.382 Q96PE6 E28K Polymorphism 0.174 0.236 0.02 39 0.335 Q96PE6 L69M Polymorphism 0.292 0.086 0.28 -44 0.200 Q96PE6 G205R Polymorphism 0.067 0.283 0.52 -2 0.039 Q96PE6 I379V Polymorphism 0.174 0.293 0.56 -20 0.234 Q96PE7 R104L Polymorphism 0.234 0.444 0.58 -7 0.345 Q96PF2 K27R Polymorphism NA 0.628 0.05 -32 0.487 Q96PF2 C245S Polymorphism 0.400 0.431 0.01 15 0.453 Q96PF2 T280M Polymorphism 0.019 0.126 0.11 -17 0.195 Q96PF2 Y197C Polymorphism 0.466 0.720 0.16 46 0.848 Q96PG2 P219L Polymorphism 0.244 0.050 0.10 17 0.040 Q96PH1 R576H Polymorphism 0.376 0.507 0.01 19 0.666 Q96PI1 P45S Polymorphism NA 0.106 NA 2 0.061 Q96PJ5 R60Q Polymorphism 0.262 0.500 0.58 44 0.383 Q96PJ5 N255S Polymorphism 0.368 0.442 0.09 9 0.433 Q96PJ5 Y493C Polymorphism NA 0.348 0.14 57 0.301 Q96PK2 I39V Polymorphism NA 0.131 1.00 7 0.101 Q96PK2 T498I Polymorphism NA 0.304 NA 37 0.184 Q96PK2 A4852T Polymorphism NA 0.258 0.58 -38 0.183 Q96PK2 K1743T Polymorphism NA 0.150 NA 19 0.139 Q96PK2 K4745R Polymorphism 0.374 0.250 0.30 -3 0.285 Q96PK2 M2792V Polymorphism NA 0.058 0.44 -11 0.085 Q96PK2 T5296I Polymorphism 0.614 0.201 0.14 12 0.514 Q96PL5 H26Y Polymorphism NA 0.058 0.09 32 0.102 Q96PL5 C259R Polymorphism 0.649 0.539 0.44 41 0.383 Q96PN7 T431A Polymorphism 0.202 0.111 0.68 5 0.061 Q96PN8 I71V Polymorphism 0.135 0.038 1.00 0 0.058 Q96PN8 S235L Polymorphism 0.661 0.720 0.04 37 0.704 Q96PP8 E4Q Polymorphism NA 0.425 0.05 -11 0.276 Q96PP8 T35M Polymorphism NA 0.293 0.01 19 0.379 Q96PP9 E546K Polymorphism 0.176 0.100 1.00 -26 0.102 Q96PP9 E551G Polymorphism 0.352 0.252 0.36 11 0.394 Q96PP9 E551K Polymorphism 0.180 0.137 0.86 -24 0.117 Q96PP9 M542I Polymorphism 0.418 0.098 1.00 -27 0.100 Q96PP9 M545I Polymorphism 0.150 0.297 0.20 29 0.219 Q96PP9 M545L Polymorphism 0.423 0.158 1.00 -11 0.101 Q96PP9 Y541N Polymorphism 0.543 0.135 1.00 -34 0.064 Q96PQ0 T745I Polymorphism 0.350 0.414 0.07 27 0.501 Q96PQ1 A82V Polymorphism NA 0.124 0.13 18 0.243 Q96PQ1 P81T Polymorphism NA 0.727 0.26 34 0.673 Q96PQ1 G218R Polymorphism 0.848 0.776 0.60 54 0.928 Q96PQ1 H217Q Polymorphism 0.485 0.159 0.70 15 0.135 Q96PQ1 H398Y Polymorphism 0.311 0.245 1.00 46 0.402 Q96PQ1 Y494S Polymorphism 0.176 0.110 0.70 -4 0.108 Q96PQ1 Y586C Polymorphism 0.353 0.058 0.06 32 0.086 Q96PQ6 Q19H Polymorphism NA 0.071 0.61 19 0.039 Q96PQ7 I10L Polymorphism NA 0.179 NA -49 0.074 Q96PQ7 G508S Polymorphism 0.861 0.878 0.28 22 0.723 Q96PS8 R15Q Polymorphism 0.365 0.607 0.64 19 0.437 Q96PS8 H123Y Polymorphism 0.393 0.769 1.00 -2 0.386 Q96PT3 A60V Polymorphism NA 0.349 0.22 16 0.393 Q96PT3 P118L Polymorphism 0.495 0.588 0.30 37 0.590 Q96PT3 S180A Polymorphism 0.041 0.109 0.54 -4 0.077 Q96PT3 S180T Polymorphism 0.046 0.235 0.54 -1 0.136 Q96PU5 P355L Polymorphism 0.091 0.323 0.40 -11 0.196 Q96PV4 R349W Polymorphism 0.812 0.131 0.19 37 0.296 Q96PV7 P816S Polymorphism 0.487 0.122 NA 10 0.057 Q96PX1 P80H Polymorphism 0.613 0.585 0.00 15 0.541 Q96PX8 L552M Polymorphism 0.233 0.083 0.18 44 0.249 Q96PX9 A72T Polymorphism NA 0.111 0.14 21 0.102 Q96PX9 V37A Polymorphism NA 0.235 0.43 11 0.063 Q96PX9 G149S Polymorphism NA 0.126 0.23 27 0.015 Q96PY6 I10F Polymorphism 0.963 0.832 0.00 60 0.949 Q96PY6 A463V Polymorphism 0.585 0.303 NA 33 0.434 Q96PY6 A598T Polymorphism NA 0.182 NA -8 0.142 Q96PY6 E724G Polymorphism NA 0.155 NA 44 0.154 Q96PY6 Q883E Polymorphism NA 0.243 NA 1 0.233 Q96PY6 D1180N Polymorphism NA 0.258 NA 60 0.475 Q96PZ7 G3312W Polymorphism NA 0.801 0.11 62 0.798 Q96PZ7 M2041I Polymorphism NA 0.299 0.36 44 0.230 Q96PZ7 Q3370H Polymorphism NA 0.738 0.08 64 0.622 Q96PZ7 S3479N Polymorphism NA 0.045 1.00 -21 0.012 Q96Q04 V900L Polymorphism NA 0.118 0.22 5 0.085 Q96Q06 S659G Polymorphism NA 0.126 0.75 -20 0.096 Q96Q06 A1124T Polymorphism NA 0.111 0.18 53 0.108 Q96Q06 R1134C Polymorphism 0.565 0.080 0.09 50 0.081 Q96Q27 P160S Polymorphism 0.779 0.285 0.01 49 0.664 Q96Q42 E159K Polymorphism 0.319 0.429 0.69 51 0.550 Q96Q80 A211V Polymorphism 0.323 0.137 0.24 -11 0.231 Q96Q80 F149L Polymorphism 0.350 0.681 0.30 17 0.483 Q96Q83 D228E Polymorphism NA 0.215 0.26 -7 0.222 Q96Q89 E490D Polymorphism 0.072 0.151 0.31 29 0.122 Q96Q89 E1127Q Polymorphism 0.402 0.109 0.00 30 0.155 Q96Q89 I1789V Polymorphism NA 0.113 NA 1 0.113 Q96QA5 R18Q Polymorphism 0.355 0.100 0.51 21 0.201 Q96QB1 L81V Polymorphism NA 0.045 NA 5 0.032 Q96QB1 R27C Polymorphism NA 0.151 NA -5 0.025 Q96QB1 H998Q Polymorphism NA 0.089 0.06 14 0.107 Q96QB1 N712S Polymorphism 0.143 0.169 0.30 12 0.140 Q96QB1 Q254H Polymorphism NA 0.231 NA 54 0.228 Q96QB1 Q320H Polymorphism NA 0.083 0.00 -7 0.032 Q96QB1 S1209C Polymorphism 0.805 0.588 0.08 39 0.758 Q96QB1 V1025A Polymorphism 0.235 0.350 0.52 34 0.304 Q96QC0 R173P Polymorphism 0.146 0.411 0.01 -17 0.240 Q96QD5 A192T Polymorphism 0.311 0.116 0.59 -2 0.115 Q96QD8 N48K Polymorphism NA 0.220 0.89 15 0.351 Q96QE3 N699H Polymorphism NA 0.080 NA 34 0.080 Q96QE5 I348V Polymorphism 0.113 0.032 1.00 -42 0.022 Q96QF7 R471H Polymorphism 0.363 0.143 0.04 25 0.123 Q96QK1 V602D Polymorphism 0.772 0.720 0.02 55 0.889 Q96QP1 Q67R Polymorphism NA 0.417 NA 43 0.599 Q96QP1 E910D Polymorphism NA 0.262 NA 17 0.174 Q96QP1 G681D Polymorphism NA 0.262 NA 16 0.113 Q96QP1 G870S Polymorphism NA 0.216 NA 27 0.076 Q96QP1 H642R Polymorphism NA 0.043 NA 26 0.067 Q96QP1 L320M Polymorphism NA 0.020 NA -47 0.009 Q96QP1 N175D Polymorphism NA 0.273 NA 13 0.147 Q96QP1 N916D Polymorphism NA 0.031 NA 19 0.028 Q96QP1 P660L Polymorphism NA 0.087 NA 7 0.040 Q96QP1 T292M Polymorphism NA 0.378 NA 58 0.447 Q96QP1 A1160G Polymorphism 0.481 0.766 0.03 49 0.842 Q96QP1 R1084Q Polymorphism 0.159 0.193 0.09 35 0.302 Q96QS3 A521T Disease 0.154 0.105 0.19 -9 0.115 Q96QS3 L343Q Disease 0.963 0.870 0.00 47 0.908 Q96QS3 P353L Disease 0.998 0.851 1.00 49 0.921 Q96QS3 P353R Disease 0.998 0.909 0.02 70 0.940 Q96QS3 R332H Disease 0.999 0.857 0.00 72 0.952 Q96QS3 R332P Disease 0.999 0.941 0.00 74 0.952 Q96QS3 T333N Disease 0.929 0.753 0.00 67 0.928 Q96QS6 G72D Polymorphism NA 0.921 0.00 82 0.932 Q96QS6 G211R Polymorphism 0.095 0.672 0.40 33 0.055 Q96QS6 R148Q Polymorphism 0.427 0.643 0.32 27 0.584 Q96QS6 S266R Polymorphism 0.195 0.635 0.09 23 0.288 Q96QT4 G68V Polymorphism 0.325 0.408 0.01 30 0.368 Q96QT4 F949Y Polymorphism NA 0.523 0.85 35 0.470 Q96QT4 A1254V Polymorphism 0.500 0.116 0.12 14 0.221 Q96QT4 D1306E Polymorphism 0.433 0.110 0.30 -13 0.103 Q96QT4 I1145V Polymorphism 0.249 0.102 0.30 8 0.188 Q96QT4 I1211T Polymorphism 0.549 0.475 0.00 5 0.648 Q96QT4 Q1064R Polymorphism 0.478 0.612 0.46 45 0.525 Q96QT4 R1444K Polymorphism 0.162 0.134 NA -8 0.044 Q96QT4 T1482I Polymorphism 0.354 0.234 NA 10 0.156 Q96QU1 S19A Polymorphism 0.119 0.306 0.04 -62 0.238 Q96QU1 D435A Polymorphism NA 0.319 0.44 6 0.287 Q96QU1 G262D Disease NA 0.303 0.33 44 0.296 Q96QU1 G380S Polymorphism NA 0.478 0.78 -22 0.173 Q96QU1 R134G Disease 0.644 0.179 0.24 29 0.467 Q96QU1 R929Q Polymorphism NA 0.348 0.58 12 0.214 Q96QU1 Q1342K Disease NA 0.464 1.00 30 0.315 Q96QU8 V1029L Polymorphism 0.256 0.522 0.10 28 0.440 Q96QV1 V341I Polymorphism 0.074 0.180 0.82 11 0.089 Q96QZ0 G95R Polymorphism NA 0.046 0.57 14 0.041 Q96R08 C141Y Polymorphism 0.285 0.752 1.00 -12 0.274 Q96R09 V208A Polymorphism 0.422 0.511 0.08 -38 0.340 Q96R28 C235R Polymorphism 0.436 0.707 0.80 4 0.316 Q96R48 A255T Polymorphism 0.598 0.699 0.28 -15 0.517 Q96R67 V283L Polymorphism 0.217 0.208 1.00 -30 0.149 Q96RA2 T197M Polymorphism 0.215 0.437 0.37 -9 0.159 Q96RB7 S171N Polymorphism 0.189 0.104 1.00 -10 0.160 Q96RB7 V280L Polymorphism 0.188 0.883 0.05 -1 0.467 Q96RC9 E22G Polymorphism 0.175 0.469 0.13 25 0.291 Q96RC9 C178R Polymorphism 0.968 0.929 0.00 82 0.942 Q96RD0 L27F Polymorphism 0.259 0.872 0.08 5 0.490 Q96RD0 L164F Polymorphism 0.218 0.414 1.00 -20 0.273 Q96RD1 C130Y Polymorphism 0.979 0.239 1.00 -4 0.132 Q96RD1 H165D Polymorphism 0.740 0.596 0.79 29 0.389 Q96RD1 V246I Polymorphism 0.200 0.623 0.24 11 0.408 Q96RD2 F105Y Polymorphism 0.579 0.866 0.08 46 0.891 Q96RD3 I39V Polymorphism 0.121 0.059 1.00 -51 0.039 Q96RD3 S95P Polymorphism 0.451 0.856 0.25 30 0.569 Q96RD3 F170Y Polymorphism 0.219 0.328 0.03 35 0.413 Q96RD3 I159V Polymorphism 0.122 0.071 0.54 -27 0.106 Q96RD3 M199R Polymorphism 0.187 0.856 0.10 15 0.477 Q96RD7 I272V Polymorphism NA 0.060 0.35 -45 0.053 Q96RD9 Q457R Polymorphism 0.348 0.222 0.61 27 0.282 Q96RF0 K593T Polymorphism NA 0.064 NA 35 0.051 Q96RG2 E796K Polymorphism NA 0.354 NA 31 0.218 Q96RG2 L514S Polymorphism NA 0.185 NA -4 0.069 Q96RG2 P844Q Polymorphism NA 0.108 NA 33 0.102 Q96RG2 Q426R Polymorphism NA 0.190 NA 18 0.163 Q96RG2 R937H Polymorphism NA 0.117 0.00 32 0.166 Q96RG2 T512A Polymorphism NA 0.044 NA 29 0.062 Q96RG2 V694M Polymorphism NA 0.096 NA 30 0.081 Q96RG2 F1266C Polymorphism 0.203 0.468 0.00 -40 0.258 Q96RI0 F296V Polymorphism 0.919 0.755 0.00 36 0.840 Q96RI0 P310L Polymorphism 0.601 0.458 0.68 -22 0.481 Q96RI0 R215Q Polymorphism 0.414 0.388 0.10 32 0.413 Q96RI8 A228V Polymorphism 0.463 0.465 0.16 -9 0.324 Q96RI8 C291Y Polymorphism 0.640 0.722 1.00 -15 0.674 Q96RI8 V265I Polymorphism 0.357 0.177 0.02 22 0.279 Q96RI9 A278T Polymorphism 0.343 0.324 0.58 -21 0.180 Q96RJ0 R23C Polymorphism 0.951 0.758 0.00 31 0.850 Q96RJ0 T252A Polymorphism 0.785 0.826 0.02 33 0.847 Q96RK0 S982G Polymorphism 0.260 0.128 0.09 20 0.057 Q96RK4 K46R Polymorphism NA 0.405 0.58 -13 0.240 Q96RK4 A364E Disease 0.410 0.733 0.10 65 0.849 Q96RK4 D368G Disease 0.391 0.751 0.07 33 0.629 Q96RK4 I354T Polymorphism 0.062 0.253 0.03 6 0.166 Q96RK4 L327P Disease 0.667 0.486 0.00 54 0.783 Q96RK4 L351R Disease 0.554 0.564 0.04 68 0.784 Q96RK4 M472V Disease NA 0.239 0.19 1 0.135 Q96RK4 N165H Disease 0.182 0.325 0.57 14 0.333 Q96RK4 P503L Disease NA 0.110 0.00 6 0.158 Q96RK4 R295P Disease 0.566 0.298 0.05 62 0.868 Q96RK4 S457I Disease 0.276 0.107 0.20 14 0.092 Q96RL1 P435L Polymorphism NA 0.281 0.00 4 0.408 Q96RL7 I90K Disease NA 0.685 0.11 53 0.829 Q96RL7 F565L Polymorphism 0.153 0.465 0.42 -30 0.236 Q96RL7 V898A Polymorphism 0.225 0.125 0.59 10 0.122 Q96RL7 A1095P Disease 0.720 0.838 0.28 24 0.862 Q96RL7 I2486T Polymorphism 0.297 0.441 0.26 43 0.547 Q96RL7 R1490K Polymorphism 0.153 0.176 1.00 -10 0.106 Q96RL7 S1452P Disease 0.380 0.308 0.15 18 0.415 Q96RL7 V1973I Polymorphism 0.123 0.243 0.51 19 0.214 Q96RL7 W2460R Disease 0.894 0.596 0.04 39 0.779 Q96RL7 Y1587C Polymorphism 0.656 0.275 0.02 41 0.485 Q96RL7 Y2721C Disease 0.750 0.528 0.12 35 0.750 Q96RN1 I639V Polymorphism 0.048 0.135 0.36 40 0.113 Q96RN1 S230N Polymorphism 0.053 0.699 0.29 24 0.106 Q96RP7 A467V Polymorphism 0.354 0.118 0.15 -15 0.244 Q96RP7 R353Q Polymorphism NA 0.056 0.42 -28 0.099 Q96RP8 M418T Polymorphism 0.084 0.149 0.72 21 0.087 Q96RP8 P189R Polymorphism 0.062 0.245 0.57 29 0.237 Q96RP9 M496R Disease NA 0.949 0.00 77 0.885 Q96RP9 N174S Disease 0.861 0.888 0.00 61 0.789 Q96RP9 V215I Polymorphism NA 0.351 1.00 -5 0.257 Q96RQ3 A289V Disease 0.509 0.857 0.01 54 0.817 Q96RQ3 D532H Disease 0.362 0.428 0.13 54 0.655 Q96RQ3 L437P Disease 0.812 0.882 0.00 60 0.903 Q96RQ3 M325R Disease 0.583 0.781 0.03 51 0.655 Q96RQ3 N560T Polymorphism 0.208 0.582 0.63 1 0.235 Q96RQ3 R385S Disease 0.994 0.861 0.00 66 0.831 Q96RQ3 S535F Disease 0.440 0.428 0.06 30 0.507 Q96RQ9 A501S Polymorphism 0.290 0.805 0.23 22 0.537 Q96RR1 A359T Disease 0.362 0.743 0.11 29 0.624 Q96RR1 A475P Disease 0.754 0.936 0.16 62 0.911 Q96RR1 E427G Polymorphism 0.564 0.607 0.14 42 0.749 Q96RR1 I367T Disease 0.529 0.912 0.02 48 0.822 Q96RR1 K319E Disease 0.197 0.091 0.44 -4 0.101 Q96RR1 K319T Disease 0.486 0.059 0.15 14 0.106 Q96RR1 L381P Disease 0.908 0.935 0.01 55 0.840 Q96RR1 P335L Disease 0.658 0.538 0.60 20 0.652 Q96RR1 R354P Disease 0.349 0.703 0.07 35 0.509 Q96RR1 R374Q Disease 0.755 0.560 0.15 61 0.908 Q96RR1 S369P Disease 0.551 0.727 0.02 41 0.728 Q96RR1 S369Y Disease 0.677 0.330 0.01 45 0.564 Q96RR1 T457I Disease 0.378 0.277 0.05 3 0.354 Q96RR1 W315L Disease 0.424 0.431 0.31 39 0.459 Q96RR1 W474C Disease 0.906 0.749 0.06 57 0.919 Q96RR1 Y508C Disease 0.825 0.822 0.14 43 0.856 Q96RR4 C123Y Polymorphism NA 0.201 0.41 18 0.128 Q96RR4 R492H Polymorphism 0.218 0.630 0.05 16 0.460 Q96RS0 F754C Polymorphism 0.074 0.106 0.27 1 0.101 Q96RT1 K914R Polymorphism NA 0.133 0.01 30 0.163 Q96RT1 S274L Polymorphism NA 0.462 0.62 26 0.230 Q96RT6 I682V Polymorphism 0.082 0.144 0.44 5 0.091 Q96RT7 L104P Polymorphism NA 0.402 NA 0 0.481 Q96RT7 L567S Polymorphism 0.066 0.124 0.02 11 0.038 Q96RT7 T1377A Polymorphism NA 0.121 NA -22 0.089 Q96RT7 V1621L Polymorphism NA 0.061 0.23 -15 0.063 Q96RU7 R153H Polymorphism 0.429 0.801 0.04 -15 0.526 Q96RU8 R298C Polymorphism 0.930 0.540 0.04 29 0.780 Q96RU8 V267I Polymorphism 0.270 0.137 0.21 -15 0.247 Q96RV3 A594T Polymorphism NA 0.137 0.44 38 0.066 Q96RV3 L814I Polymorphism NA 0.077 0.40 19 0.072 Q96RW7 D5087V Polymorphism 0.466 0.267 0.00 45 0.467 Q96RW7 E2893G Polymorphism NA 0.273 0.28 54 0.568 Q96RW7 H4084Y Polymorphism 0.331 0.205 0.14 46 0.383 Q96RW7 I2418T Polymorphism NA 0.372 0.10 45 0.524 Q96RW7 M2327I Polymorphism NA 0.213 0.39 46 0.357 Q96RW7 Q5345R Disease 0.105 0.571 0.75 49 0.485 Q96RW7 T1056A Polymorphism NA 0.250 0.67 11 0.208 Q96RW7 V1184F Polymorphism NA 0.257 0.08 41 0.462 Q96RY7 R621Q Polymorphism 0.079 0.031 NA -2 0.077 Q96RY7 V398I Polymorphism 0.191 0.074 NA -9 0.053 Q96RY7 A1070V Polymorphism 0.205 0.353 0.27 -1 0.226 Q96S06 P562R Polymorphism NA 0.254 0.00 17 0.418 Q96S06 R364Q Polymorphism NA 0.099 0.00 21 0.231 Q96S06 S203P Polymorphism NA 0.736 0.14 -42 0.467 Q96S06 V164A Polymorphism NA 0.829 0.00 28 0.650 Q96S37 R90H Disease 0.521 0.358 0.00 28 0.619 Q96S37 A226V Polymorphism 0.221 0.429 0.05 -2 0.130 Q96S37 E298D Disease 0.292 0.400 0.52 12 0.461 Q96S37 G164S Disease 0.979 0.835 0.02 33 0.862 Q96S37 L418R Disease 0.651 0.771 0.16 47 0.816 Q96S37 M430T Disease 0.441 0.582 0.43 36 0.424 Q96S37 Q312L Polymorphism 0.289 0.556 0.45 -27 0.247 Q96S37 Q382L Disease 0.896 0.857 0.06 43 0.851 Q96S37 R477H Disease 0.915 0.940 0.55 21 0.905 Q96S37 T217M Disease 0.562 0.561 0.08 0 0.507 Q96S37 V138M Disease 0.974 0.932 0.00 68 0.913 Q96S38 E96K Polymorphism 0.203 0.444 0.17 -14 0.323 Q96S38 P42T Polymorphism 0.196 0.613 0.00 34 0.657 Q96S38 A546P Polymorphism 0.602 0.253 0.23 -14 0.434 Q96S38 P319L Polymorphism 0.110 0.071 0.00 18 0.149 Q96S38 P424L Polymorphism 0.341 0.202 0.02 11 0.310 Q96S38 P561R Polymorphism 0.861 0.227 0.10 41 0.453 Q96S42 H165R Polymorphism 0.218 0.224 0.32 -6 0.247 Q96S42 R183Q Disease 0.061 0.121 0.65 -33 0.038 Q96S44 A25T Polymorphism 0.234 0.135 0.18 20 0.075 Q96S44 R123Q Polymorphism 0.197 0.517 0.30 -18 0.386 Q96S44 T129A Polymorphism 0.135 0.097 0.50 -65 0.154 Q96S52 R253H Polymorphism 0.348 0.196 0.13 -27 0.309 Q96S66 S368R Polymorphism NA 0.070 1.00 -26 0.014 Q96S96 K125E Polymorphism 0.264 0.371 0.65 32 0.338 Q96SB4 I72T Polymorphism 0.556 0.853 0.27 44 0.650 Q96SB8 A691T Polymorphism 0.311 0.071 0.46 -33 0.116 Q96SB8 K928Q Polymorphism 0.307 0.319 0.47 -24 0.249 Q96SB8 R464G Polymorphism 0.412 0.303 0.28 18 0.323 Q96SB8 I1046M Polymorphism 0.462 0.556 0.00 57 0.736 Q96SD1 H35D Disease NA 0.966 0.00 69 0.941 Q96SE0 P54Q Polymorphism 0.353 0.142 0.64 -29 0.126 Q96SE0 W371C Polymorphism 0.240 0.869 0.16 34 0.592 Q96SE7 M117V Polymorphism 0.324 0.207 0.58 15 0.225 Q96SK2 H505R Polymorphism 0.193 0.655 0.05 18 0.670 Q96SK3 S2A Polymorphism NA 0.346 0.55 -69 0.200 Q96SK3 R70H Polymorphism 0.709 0.230 0.13 2 0.597 Q96SK3 A653P Polymorphism 0.775 0.888 0.04 50 0.923 Q96SK3 F123L Polymorphism 0.328 0.752 0.31 28 0.574 Q96SK3 K531R Polymorphism 0.683 0.661 0.33 31 0.643 Q96SN8 A183P Polymorphism 0.585 0.719 0.01 27 0.786 Q96SN8 E289Q Polymorphism 0.144 0.097 0.06 -14 0.102 Q96SQ7 L150P Polymorphism 0.150 0.356 0.29 30 0.266 Q96SQ9 P466L Polymorphism NA 0.825 1.00 7 0.481 Q96ST2 A390V Polymorphism 0.008 0.074 0.11 -5 0.118 Q96ST2 V425I Polymorphism 0.007 0.066 0.24 -36 0.047 Q96ST8 R194W Polymorphism NA 0.108 0.07 25 0.049 Q96SZ5 P39A Polymorphism 0.127 0.077 NA 19 0.062 Q96T21 R540Q Disease 0.218 0.385 0.00 23 0.551 Q96T51 H298Q Polymorphism 0.134 0.199 0.60 15 0.267 Q96T53 T46A Polymorphism NA 0.128 0.56 -33 0.041 Q96T53 G231E Polymorphism 0.513 0.185 0.37 64 0.550 Q96T55 P301H Polymorphism NA 0.047 0.00 36 0.114 Q96T58 D1363E Polymorphism NA 0.050 NA -24 0.114 Q96T58 L1091P Polymorphism 0.666 0.110 NA -29 0.059 Q96T60 A63V Polymorphism 0.272 0.036 0.29 -19 0.061 Q96T60 R180S Polymorphism 0.146 0.350 0.05 5 0.176 Q96T60 Y196N Polymorphism 0.855 0.694 0.35 8 0.758 Q96T76 Q409P Polymorphism 0.589 0.500 0.20 55 0.731 Q96T76 R306H Polymorphism 0.581 0.443 0.02 40 0.644 Q96T76 R983H Polymorphism 0.430 0.207 0.08 -14 0.184 Q96T88 D240H Polymorphism 0.855 0.360 0.01 50 0.636 Q99062 E405K Polymorphism 0.159 0.048 0.84 36 0.057 Q99062 M231T Polymorphism 0.280 0.289 0.38 -11 0.122 Q99062 Q346R Polymorphism 0.133 0.113 0.52 39 0.171 Q99081 G300S Polymorphism 0.087 0.179 0.72 0 0.116 Q99102 S585A Polymorphism NA 0.139 0.11 5 0.132 Q99102 A1578S Polymorphism 0.080 0.208 0.05 26 0.274 Q99217 W4S Disease 0.477 0.802 0.00 29 0.756 Q99217 P56T Disease 0.354 0.642 0.02 5 0.648 Q99217 T37I Disease 0.935 0.860 0.02 25 0.882 Q99250 F385Y Polymorphism 0.222 0.221 1.00 -2 0.159 Q99250 R188W Disease NA 0.876 0.00 59 0.888 Q99250 R223Q Disease 0.866 0.910 0.00 49 0.922 Q99250 V892I Disease 0.127 0.525 0.57 -12 0.093 Q99250 L1003I Disease 0.191 0.405 0.23 -7 0.269 Q99250 L1330F Disease 0.798 0.567 0.00 7 0.717 Q99250 L1563V Disease 0.394 0.815 0.01 27 0.577 Q99250 R1319Q Disease 0.557 0.733 0.25 18 0.398 Q99259 S12C Disease NA 0.207 0.00 35 0.182 Q99259 R532Q Polymorphism 0.171 0.405 0.30 20 0.223 Q99259 V474G Polymorphism 0.170 0.634 0.38 -8 0.184 Q99435 N347D Polymorphism 0.146 0.399 0.25 21 0.258 Q99435 P631L Polymorphism 0.779 0.634 0.01 41 0.754 Q99453 Q143R Disease 0.956 0.895 0.03 42 0.846 Q99453 R141Q Disease 0.988 0.939 1.00 56 0.919 Q99456 P15S Polymorphism NA 0.286 0.72 -15 0.153 Q99456 A137P Disease 0.958 0.906 0.00 49 0.928 Q99456 I426S Disease 0.981 0.850 0.00 45 0.909 Q99456 L140R Disease 0.984 0.907 0.00 47 0.916 Q99456 M129T Disease 0.981 0.888 0.00 37 0.912 Q99456 Q130P Disease 0.970 0.958 0.00 42 0.899 Q99456 R135G Disease 0.967 0.848 0.00 38 0.887 Q99456 R135I Disease 0.981 0.837 0.00 40 0.903 Q99456 R135S Disease 0.959 0.768 0.00 33 0.873 Q99456 R135T Disease 0.962 0.916 0.00 41 0.895 Q99456 V143L Disease 0.995 0.844 0.00 35 0.917 Q99456 Y429C Disease 0.999 0.759 0.00 56 0.942 Q99456 Y429D Disease 0.999 0.699 0.00 60 0.942 Q99466 E317Q Polymorphism 0.362 0.388 0.07 13 0.375 Q99466 K117Q Polymorphism 0.317 0.213 0.26 -13 0.143 Q99466 K851R Polymorphism NA 0.275 0.17 -5 0.191 Q99466 P204L Polymorphism 0.540 0.574 0.02 18 0.518 Q99466 P206L Polymorphism 0.540 0.451 0.12 13 0.243 Q99466 Q284H Polymorphism 0.496 0.318 0.01 38 0.432 Q99466 S809I Polymorphism NA 0.572 0.01 45 0.664 Q99466 T320A Polymorphism NA 0.454 0.02 -13 0.200 Q99467 N53K Polymorphism NA 0.245 0.93 -23 0.235 Q99467 D259N Polymorphism NA 0.594 0.47 36 0.411 Q99489 H230Y Polymorphism 0.263 0.681 0.64 -1 0.268 Q99489 L255R Polymorphism 0.413 0.614 0.01 22 0.537 Q99489 Q189E Polymorphism 0.318 0.190 1.00 -32 0.160 Q99490 G507S Polymorphism NA 0.159 0.07 -55 0.150 Q99490 G1124V Polymorphism 0.952 0.782 0.00 55 0.934 Q99497 E64D Disease 0.117 0.517 0.63 -32 0.068 Q99497 M26I Disease NA 0.756 0.43 14 0.640 Q99497 R98Q Polymorphism 0.183 0.244 0.49 -13 0.152 Q99497 A104T Disease 0.761 0.859 0.34 58 0.914 Q99497 D149A Disease 0.462 0.835 0.01 65 0.887 Q99497 L166P Disease 0.904 0.942 0.20 54 0.935 Q99501 S490G Polymorphism NA 0.028 0.16 -4 0.057 Q99502 P20A Polymorphism NA 0.160 0.00 0 0.256 Q99502 D429G Disease 0.635 0.966 0.00 50 0.903 Q99502 G426S Disease 0.667 0.951 0.00 55 0.919 Q99502 L505R Disease 0.871 0.981 0.00 65 0.945 Q99502 L583P Disease 0.846 0.952 0.00 63 0.948 Q99502 R440Q Disease 0.535 0.705 0.03 41 0.806 Q99502 S242G Disease NA 0.532 0.04 51 0.689 Q99502 S487P Disease 0.343 0.843 0.15 53 0.857 Q99518 F69Y Polymorphism 0.286 0.463 0.72 6 0.345 Q99518 F81S Polymorphism 0.869 0.747 0.00 40 0.866 Q99518 N413K Polymorphism 0.394 0.600 1.00 -31 0.299 Q99518 R238Q Polymorphism 0.529 0.716 0.03 22 0.592 Q99518 R391T Polymorphism 0.707 0.690 0.02 20 0.811 Q99519 G68V Disease NA 0.595 0.26 36 0.488 Q99519 G88A Polymorphism NA 0.858 0.25 55 0.826 Q99519 L91R Disease NA 0.971 0.00 58 0.922 Q99519 P80L Disease NA 0.933 0.00 52 0.899 Q99519 V54M Disease NA 0.150 0.00 48 0.289 Q99519 A298V Disease 0.413 0.397 0.42 -33 0.423 Q99519 F260Y Disease 0.229 0.507 0.08 19 0.427 Q99519 G219A Disease 0.185 0.476 1.00 -14 0.256 Q99519 G227R Disease 0.367 0.777 0.23 41 0.630 Q99519 G243R Disease 0.334 0.967 0.01 72 0.911 Q99519 G328S Disease 0.162 0.434 0.84 7 0.226 Q99519 L231H Disease 0.270 0.605 0.01 51 0.721 Q99519 L270F Disease 0.453 0.775 0.19 37 0.802 Q99519 L270P Disease 0.767 0.971 0.07 42 0.860 Q99519 L363P Disease 0.582 0.935 0.00 10 0.729 Q99519 P316S Disease 0.170 0.795 0.27 -5 0.347 Q99519 P335Q Disease 0.152 0.814 0.00 42 0.697 Q99519 R225P Disease 0.276 0.603 0.30 -4 0.317 Q99519 R294S Disease 0.077 0.486 0.70 41 0.333 Q99519 R341G Disease 0.241 0.960 0.00 60 0.912 Q99519 S182G Disease 0.161 0.828 0.35 -10 0.269 Q99519 V217M Disease 0.317 0.611 0.04 44 0.595 Q99519 W240R Disease 0.109 0.969 0.00 74 0.920 Q99519 Y370C Disease 0.819 0.970 0.00 58 0.945 Q99527 P16L Polymorphism NA 0.171 0.68 6 0.138 Q99538 V18I Polymorphism 0.080 0.067 0.16 18 0.084 Q99542 P488T Polymorphism 0.434 0.233 0.21 -31 0.239 Q99542 R103C Polymorphism 0.841 0.852 0.00 38 0.885 Q99547 I58V Polymorphism 0.262 0.136 NA 0 0.139 Q99550 G125S Polymorphism NA 0.199 NA 6 0.111 Q99551 A231T Polymorphism 0.066 0.038 0.55 -28 0.019 Q99551 A294T Polymorphism 0.077 0.028 0.85 -36 0.022 Q99558 P928H Polymorphism 0.703 0.278 NA 38 0.538 Q99558 T764A Polymorphism 0.203 0.047 0.06 19 0.050 Q99570 D393N Polymorphism NA 0.046 0.01 5 0.092 Q99570 F273L Polymorphism NA 0.075 0.67 -37 0.081 Q99570 L699V Polymorphism NA 0.295 0.26 -40 0.231 Q99570 R342H Polymorphism NA 0.720 0.01 -17 0.525 Q99570 R347W Polymorphism NA 0.225 0.08 39 0.260 Q99570 G1043V Polymorphism NA 0.659 0.00 55 0.643 Q99571 A6S Polymorphism NA 0.028 1.00 -53 0.047 Q99572 V76A Polymorphism 0.064 0.149 0.27 27 0.135 Q99572 A348T Polymorphism 0.102 0.058 1.00 -32 0.023 Q99572 A433V Polymorphism 0.119 0.056 0.12 9 0.064 Q99572 E496A Polymorphism NA 0.388 0.00 40 0.624 Q99572 G150R Polymorphism 0.984 0.921 0.00 59 0.963 Q99572 H521Q Polymorphism NA 0.083 0.21 -5 0.035 Q99572 P430R Polymorphism 0.454 0.161 0.01 29 0.219 Q99572 R270C Polymorphism 0.614 0.576 0.19 11 0.585 Q99572 R270H Polymorphism 0.310 0.394 0.56 -18 0.193 Q99572 R276H Polymorphism 0.696 0.817 0.16 29 0.684 Q99572 R307Q Polymorphism 0.515 0.974 0.00 74 0.943 Q99574 S49P Disease NA 0.950 0.02 68 0.946 Q99574 S52R Disease NA 0.944 0.01 66 0.946 Q99575 E460A Polymorphism 0.462 0.198 0.40 9 0.234 Q99575 K522N Polymorphism 0.462 0.407 0.22 26 0.455 Q99575 L994V Polymorphism NA 0.081 NA 11 0.140 Q99575 S127L Polymorphism 0.287 0.385 0.54 34 0.377 Q99590 V1261L Polymorphism 0.521 0.097 0.03 14 0.128 Q99593 G80R Disease 0.997 0.958 0.00 65 0.954 Q99593 I54T Disease 0.614 0.349 0.03 17 0.606 Q99593 Q49K Disease NA 0.238 0.35 25 0.291 Q99593 R237Q Disease 0.983 0.932 0.01 60 0.952 Q99593 R237W Disease 0.997 0.957 0.00 64 0.951 Q99616 A5S Polymorphism 0.415 0.265 0.12 -68 0.305 Q99616 N29S Polymorphism 0.115 0.106 0.72 0 0.106 Q99638 C3F Polymorphism 0.192 0.584 1.00 -14 0.366 Q99638 L71Q Polymorphism 0.643 0.605 0.00 16 0.615 Q99638 S100A Polymorphism 0.254 0.217 0.71 -2 0.212 Q99640 P417R Polymorphism 0.135 0.119 0.60 39 0.104 Q99640 R140C Polymorphism 0.472 0.787 0.12 13 0.788 Q99640 R246H Polymorphism 0.313 0.188 0.21 -31 0.192 Q99640 V445A Polymorphism 0.269 0.110 0.55 34 0.099 Q99645 S150C Polymorphism 0.536 0.476 0.09 18 0.562 Q99650 D553N Polymorphism 0.447 0.290 0.50 -8 0.114 Q99650 E527K Polymorphism 0.144 0.128 0.87 41 0.174 Q99650 G618A Disease 0.789 0.255 0.24 17 0.461 Q99650 H187Q Polymorphism NA 0.139 0.38 16 0.131 Q99650 I691T Disease 0.414 0.414 0.01 52 0.502 Q99650 P936S Polymorphism NA 0.149 0.00 34 0.064 Q99665 M13V Polymorphism NA 0.069 0.44 -39 0.018 Q99665 G420R Polymorphism 0.322 0.141 0.50 48 0.253 Q99665 G465D Polymorphism 0.158 0.484 0.33 40 0.269 Q99665 H720R Polymorphism 0.124 0.085 1.00 16 0.061 Q99665 I185V Polymorphism 0.125 0.186 0.62 -1 0.170 Q99665 L808R Polymorphism NA 0.470 0.02 29 0.359 Q99665 Q426H Polymorphism 0.581 0.072 0.15 25 0.144 Q99665 R149Q Polymorphism 0.271 0.725 0.54 51 0.518 Q99665 T201I Polymorphism 0.505 0.220 0.25 28 0.361 Q99674 K232N Polymorphism 0.207 0.089 0.08 16 0.048 Q99678 R260C Polymorphism 0.789 0.789 0.18 19 0.731 Q99683 D1315N Polymorphism NA 0.079 0.03 -9 0.100 Q99683 T1314I Polymorphism NA 0.097 1.00 -33 0.079 Q99684 S36N Polymorphism 0.163 0.059 0.10 18 0.078 Q99684 K403R Disease NA 0.321 0.17 15 0.341 Q99684 N382S Disease 0.433 0.313 0.79 -12 0.251 Q99689 D123E Polymorphism 0.312 0.156 0.25 -10 0.241 Q99697 K134E Disease 0.686 0.521 0.00 66 0.906 Q99697 L100Q Disease 0.888 0.866 0.00 44 0.894 Q99697 L151V Disease 0.368 0.353 0.52 24 0.354 Q99697 N154T Disease 0.438 0.230 0.53 -22 0.273 Q99697 P110L Disease 0.887 0.854 1.00 44 0.869 Q99697 P110R Disease 0.893 0.902 0.02 56 0.924 Q99697 R108H Disease 0.855 0.074 0.46 48 0.214 Q99697 R115H Disease 0.855 0.872 0.00 63 0.931 Q99697 R130W Disease 0.953 0.883 0.00 57 0.932 Q99697 R136C Disease 0.935 0.833 0.00 71 0.929 Q99697 R137P Disease 0.868 0.894 0.00 81 0.926 Q99697 T114P Disease 0.649 0.843 0.09 57 0.898 Q99697 V129L Disease 0.497 0.603 0.00 30 0.770 Q99698 E702G Polymorphism NA 0.165 0.00 -15 0.105 Q99698 H123R Polymorphism NA 0.129 0.00 -45 0.144 Q99698 L192V Polymorphism NA 0.094 0.00 27 0.090 Q99698 F2598Y Polymorphism NA 0.372 0.00 35 0.432 Q99698 G2804D Polymorphism NA 0.128 0.99 40 0.051 Q99698 R1563H Disease NA 0.230 0.00 -8 0.440 Q99698 T2116M Polymorphism NA 0.108 0.02 22 0.015 Q99698 V1999D Disease NA 0.368 0.00 41 0.570 Q99698 V2936I Polymorphism 0.827 0.210 0.04 9 0.309 Q99700 S248N Polymorphism NA 0.167 0.05 23 0.144 Q99705 R210H Polymorphism 0.997 0.794 0.00 71 0.942 Q99705 T411M Polymorphism 0.373 0.374 0.01 20 0.409 Q99705 Y250H Polymorphism 0.800 0.461 0.02 16 0.627 Q99706 Y53C Polymorphism 0.094 0.146 0.05 10 0.169 Q99706 D271N Polymorphism 0.137 0.158 1.00 -18 0.100 Q99707 R61K Polymorphism NA 0.257 0.68 -26 0.186 Q99707 D919G Polymorphism 0.179 0.381 0.21 -8 0.165 Q99707 H920D Disease 0.390 0.719 0.09 44 0.682 Q99707 P1173L Disease NA 0.666 0.22 34 0.797 Q99708 H387Y Polymorphism 0.312 0.088 0.07 25 0.100 Q99708 K357N Polymorphism 0.121 0.044 0.67 -51 0.055 Q99714 L122V Disease 0.173 0.636 0.18 7 0.254 Q99714 N247S Disease 0.607 0.733 0.03 57 0.626 Q99714 R130C Disease 0.881 0.930 0.00 49 0.907 Q99715 A461P Polymorphism 0.668 0.380 0.18 51 0.673 Q99715 I1738T Polymorphism NA 0.196 0.84 17 0.225 Q99715 I2596V Polymorphism NA 0.351 0.04 0 0.258 Q99720 R211Q Polymorphism NA 0.103 0.33 7 0.094 Q99728 P24S Polymorphism NA 0.143 0.00 17 0.039 Q99728 C557S Polymorphism NA 0.434 0.05 -1 0.294 Q99728 C645R Polymorphism 0.216 0.403 0.85 30 0.230 Q99728 R378S Polymorphism NA 0.457 0.07 24 0.316 Q99728 R658C Polymorphism 0.507 0.302 0.00 47 0.584 Q99728 S186G Polymorphism NA 0.127 0.01 -55 0.169 Q99728 S241C Polymorphism NA 0.218 0.06 22 0.390 Q99728 S728F Polymorphism 0.370 0.568 0.00 36 0.715 Q99728 V507M Polymorphism 0.335 0.181 0.12 -42 0.247 Q99732 T49M Disease 0.315 0.122 0.16 1 0.121 Q99732 G112S Disease 0.488 0.915 0.00 46 0.682 Q99732 L122V Disease 0.434 0.276 0.15 35 0.382 Q99732 T115N Disease 0.234 0.603 0.60 53 0.445 Q99732 W116G Disease 0.940 0.854 0.00 65 0.943 Q99735 A101V Polymorphism 0.093 0.443 0.21 -6 0.204 Q99741 R378H Polymorphism 0.765 0.622 0.08 41 0.819 Q99741 T238A Polymorphism 0.152 0.606 0.25 18 0.359 Q99741 T299M Polymorphism 0.695 0.519 0.06 33 0.782 Q99747 P92S Polymorphism 0.131 0.055 0.49 -29 0.074 Q99758 L101P Disease NA 0.787 0.12 -5 0.558 Q99758 N140H Polymorphism NA 0.360 0.12 9 0.430 Q99758 N568D Disease 0.987 0.873 0.00 75 0.973 Q99758 L1553P Disease 0.866 0.796 0.00 52 0.947 Q99758 Q1591P Disease 0.513 0.730 0.11 30 0.801 Q99759 A325G Polymorphism NA 0.197 0.37 25 0.227 Q99759 V281M Polymorphism NA 0.126 0.02 -24 0.165 Q99797 R340Q Polymorphism NA 0.327 0.65 -39 0.233 Q99797 S488G Polymorphism 0.154 0.590 0.63 -12 0.175 Q99798 A768S Polymorphism 0.359 0.438 0.59 7 0.371 Q99808 I216T Polymorphism 0.304 0.495 0.08 -15 0.404 Q99814 G537W Disease 0.937 0.348 0.19 36 0.516 Q99828 I106T Polymorphism 0.405 0.375 0.55 -8 0.393 Q99829 P347R Polymorphism 0.601 0.939 0.16 21 0.681 Q99829 Q211R Polymorphism 0.311 0.684 0.28 43 0.477 Q99835 D473H Polymorphism 0.534 0.600 0.00 58 0.716 Q99836 L93P Disease 0.894 0.958 NA 60 0.947 Q99836 R196C Disease 0.924 0.963 0.00 72 0.951 Q99848 R223H Polymorphism 0.222 0.104 0.14 2 0.186 Q99856 G556S Polymorphism 0.089 0.122 0.00 37 0.054 Q99873 K78M Polymorphism NA 0.743 0.02 30 0.804 Q99873 L158F Polymorphism 0.953 0.894 0.09 59 0.943 Q99884 L345V Polymorphism 0.244 0.695 0.08 -28 0.236 Q99895 D35H Polymorphism 0.611 0.561 0.05 30 0.759 Q99895 R80W Polymorphism 0.437 0.726 0.05 12 0.713 Q99895 D260N Polymorphism 0.370 0.370 0.52 0 0.279 Q99895 G217R Polymorphism 0.972 0.906 0.00 70 0.941 Q99895 L220R Polymorphism 0.963 0.885 0.00 58 0.937 Q99895 P249L Polymorphism 0.970 0.805 0.00 62 0.933 Q99928 T352A Polymorphism 0.047 0.045 0.80 1 0.097 Q99932 A69T Polymorphism 0.302 0.156 0.01 33 0.129 Q99944 R86K Polymorphism 0.091 0.187 0.29 9 0.132 Q99944 A204E Polymorphism 0.494 0.171 0.71 18 0.204 Q99954 G28R Polymorphism NA 0.088 0.82 12 0.065 Q99958 S125L Disease 0.997 0.871 0.00 57 0.838 Q99959 C796R Disease 0.857 0.895 0.01 63 0.931 Q99959 K654Q Disease 0.456 0.913 0.08 9 0.725 Q99959 S140F Disease NA 0.077 0.00 32 0.175 Q99959 S615F Disease 0.917 0.927 0.00 50 0.928 Q99972 C9S Polymorphism NA 0.495 NA 17 0.583 Q99972 A17S Polymorphism NA 0.380 0.05 -30 0.259 Q99972 C25R Disease NA 0.623 0.03 35 0.698 Q99972 G12R Polymorphism NA 0.227 NA 37 0.086 Q99972 L95P Polymorphism NA 0.665 0.00 50 0.741 Q99972 N73S Polymorphism NA 0.077 0.66 -5 0.046 Q99972 Q19H Polymorphism NA 0.384 0.19 21 0.157 Q99972 Q48H Disease NA 0.116 0.02 34 0.108 Q99972 R76K Polymorphism NA 0.500 0.40 -9 0.386 Q99972 R82C Disease NA 0.184 0.03 30 0.241 Q99972 R82H Polymorphism NA 0.149 0.20 4 0.106 Q99972 V53A Disease NA 0.254 0.01 39 0.403 Q99972 A363T Disease 0.354 0.914 0.02 56 0.849 Q99972 A427T Disease 0.354 0.361 0.01 -20 0.431 Q99972 A445V Disease 0.096 0.428 0.27 -4 0.352 Q99972 C245Y Disease NA 0.838 0.01 34 0.745 Q99972 C433R Disease 0.987 0.958 0.00 66 0.975 Q99972 D208E Disease NA 0.073 1.00 -33 0.056 Q99972 D380A Disease 0.968 0.909 0.00 54 0.950 Q99972 D380G Disease 0.960 0.944 0.00 59 0.953 Q99972 D380H Disease 0.983 0.923 0.00 68 0.953 Q99972 D380N Disease 0.957 0.946 0.00 54 0.963 Q99972 E261K Disease 0.370 0.467 0.19 -15 0.315 Q99972 E300K Disease 0.790 0.939 0.00 32 0.864 Q99972 E323K Disease 0.370 0.684 0.30 32 0.570 Q99972 E352K Disease 0.370 0.454 0.31 16 0.298 Q99972 F369L Disease 0.265 0.793 0.20 26 0.460 Q99972 G244V Disease NA 0.364 0.07 37 0.456 Q99972 G246R Disease NA 0.908 0.00 28 0.678 Q99972 G252R Disease NA 0.752 0.44 14 0.750 Q99972 G364V Disease 0.647 0.823 0.29 27 0.751 Q99972 G367R Disease 0.677 0.908 0.06 59 0.784 Q99972 G399V Disease 0.647 0.871 0.01 48 0.892 Q99972 G434S Disease 0.984 0.838 0.00 46 0.929 Q99972 I345M Disease 0.256 0.622 0.00 38 0.707 Q99972 I360N Disease 0.675 0.856 0.00 41 0.881 Q99972 I465M Disease 0.380 0.568 0.01 47 0.606 Q99972 I477N Disease 0.663 0.731 0.00 53 0.883 Q99972 I477S Disease 0.509 0.662 0.00 47 0.783 Q99972 I499F Disease 0.452 0.605 0.01 38 0.789 Q99972 I499S Disease 0.529 0.508 0.00 36 0.781 Q99972 K423E Disease 0.363 0.788 0.01 52 0.831 Q99972 L215P Polymorphism NA 0.858 0.12 46 0.847 Q99972 N450D Disease 0.329 0.307 0.77 0 0.180 Q99972 N480K Disease 0.962 0.877 0.00 57 0.948 Q99972 P274R Disease 0.643 0.926 0.01 48 0.892 Q99972 P361S Disease 0.498 0.467 0.17 12 0.415 Q99972 P370L Disease 0.622 0.853 0.01 40 0.673 Q99972 P481L Disease 0.921 0.861 0.00 28 0.873 Q99972 P481T Disease 0.895 0.869 0.01 39 0.892 Q99972 Q337E Disease 0.322 0.551 0.03 17 0.686 Q99972 Q337R Disease 0.333 0.702 0.02 44 0.745 Q99972 R126W Disease NA 0.279 0.01 16 0.383 Q99972 R158Q Disease NA 0.237 0.56 -2 0.194 Q99972 R272G Disease 0.541 0.711 0.03 34 0.814 Q99972 R342K Disease 0.253 0.471 0.56 6 0.337 Q99972 R422C Polymorphism 0.955 0.577 0.03 29 0.771 Q99972 R422H Disease 0.894 0.162 0.16 0 0.489 Q99972 R470C Disease 0.801 0.384 0.01 46 0.673 Q99972 S341P Disease 0.533 0.920 0.01 44 0.699 Q99972 S393N Disease 0.454 0.659 0.08 25 0.766 Q99972 S393R Disease 0.504 0.856 0.04 20 0.842 Q99972 S502P Disease 0.032 0.423 0.23 20 0.360 Q99972 T293K Disease 0.447 0.607 0.21 25 0.480 Q99972 T353I Disease 0.439 0.092 0.41 -21 0.160 Q99972 T377K Disease 0.447 0.767 0.01 56 0.707 Q99972 T377M Disease 0.634 0.495 0.00 54 0.871 Q99972 T438I Disease 0.439 0.290 0.17 17 0.384 Q99972 T448P Disease 0.552 0.662 0.11 -3 0.666 Q99972 V251A Disease NA 0.719 0.00 17 0.591 Q99972 V402I Polymorphism 0.450 0.473 0.00 31 0.503 Q99972 V426F Disease 0.508 0.650 0.36 0 0.454 Q99972 W286R Disease 0.666 0.760 0.00 51 0.878 Q99972 Y437H Disease 0.977 0.863 0.00 63 0.953 Q99972 Y471C Disease 0.791 0.791 0.00 63 0.912 Q99972 Y473C Polymorphism 0.950 0.635 0.01 59 0.932 Q99973 A553G Polymorphism NA 0.180 0.32 -18 0.180 Q99973 K434N Polymorphism NA 0.089 0.54 -13 0.074 Q99973 T137M Polymorphism NA 0.078 0.00 23 0.076 Q99973 A2310S Polymorphism NA 0.315 0.11 28 0.357 Q99973 C1468Y Polymorphism NA 0.185 0.95 -2 0.067 Q99973 R1351Q Polymorphism NA 0.052 0.00 2 0.098 Q99973 R1772Q Polymorphism NA 0.471 0.20 43 0.353 Q99973 S1195P Polymorphism NA 0.175 0.75 -33 0.071 Q99973 V2214I Polymorphism 0.166 0.662 0.40 35 0.215 Q99983 D200G Polymorphism 0.741 0.209 0.04 37 0.528 Q99983 E212G Polymorphism 0.444 0.633 0.04 9 0.310 Q99983 I282T Polymorphism 0.269 0.359 0.00 37 0.440 Q99985 F302S Polymorphism 0.945 0.835 0.00 21 0.875 Q99985 V337M Polymorphism 0.702 0.934 0.00 40 0.875 Q99988 V9L Polymorphism NA 0.055 1.00 -1 0.024 Q99988 H202D Polymorphism NA 0.492 0.41 25 0.436 Q99990 T59I Polymorphism 0.189 0.097 0.04 29 0.119 Q99996 M475I Polymorphism NA 0.055 0.28 30 0.070 Q99996 N2804S Polymorphism 0.485 0.021 0.31 1 0.050 Q99996 Q3448R Polymorphism 0.438 0.021 0.59 35 0.085 Q99996 S1582L Disease NA 0.024 0.01 0 0.019 Q9BPW4 I9V Polymorphism 0.100 0.033 1.00 -41 0.025 Q9BPW4 V12L Polymorphism 0.132 0.036 0.92 -41 0.020 Q9BPW4 A319E Polymorphism 0.053 0.843 0.00 33 0.301 Q9BPW4 M159V Polymorphism 0.198 0.129 0.31 -28 0.109 Q9BPW4 S326L Polymorphism 0.052 0.152 0.03 -15 0.106 Q9BPW9 D286H Polymorphism 0.855 0.744 0.04 48 0.876 Q9BPX3 A64P Polymorphism 0.596 0.612 0.35 20 0.541 Q9BPX3 M581I Polymorphism 0.113 0.201 0.94 -11 0.169 Q9BPX7 G265E Polymorphism 0.886 0.959 0.00 41 0.904 Q9BQ08 P20L Polymorphism 0.820 0.320 0.18 5 0.452 Q9BQ16 I112V Polymorphism 0.134 0.128 1.00 -5 0.123 Q9BQ50 R180C Polymorphism 0.485 0.257 0.08 27 0.373 Q9BQ51 S58T Polymorphism 0.097 0.195 0.87 -20 0.212 Q9BQ51 F229S Polymorphism 0.067 0.180 0.12 -22 0.025 Q9BQ51 I241T Polymorphism 0.163 0.238 0.11 -15 0.288 Q9BQ52 S52F Polymorphism NA 0.089 0.05 8 0.104 Q9BQ52 A541T Polymorphism 0.326 0.261 0.39 -14 0.252 Q9BQ52 D436N Polymorphism 0.387 0.333 0.33 24 0.337 Q9BQ52 S217L Polymorphism 0.208 0.182 0.22 2 0.197 Q9BQ52 S627L Polymorphism 0.233 0.230 0.31 -21 0.220 Q9BQ65 R115K Polymorphism 0.119 0.105 1.00 -30 0.067 Q9BQ89 L284I Polymorphism NA 0.100 0.77 -33 0.079 Q9BQ95 R278C Polymorphism 0.317 0.244 0.03 23 0.345 Q9BQA5 P4S Polymorphism NA 0.096 0.05 -21 0.085 Q9BQA5 S78C Polymorphism NA 0.263 0.23 -2 0.278 Q9BQB6 R58G Disease 0.293 0.722 0.00 23 0.483 Q9BQB6 R98W Disease 0.674 0.163 0.04 40 0.371 Q9BQB6 V29L Disease 0.550 0.758 0.00 28 0.664 Q9BQB6 V45A Disease 0.584 0.255 0.06 44 0.551 Q9BQB6 L128R Disease 0.776 0.982 0.00 52 0.922 Q9BQD3 P157A Polymorphism 0.087 0.041 0.23 -8 0.040 Q9BQE5 I245V Polymorphism 0.073 0.223 1.00 -29 0.042 Q9BQF6 K79Q Polymorphism 0.068 0.167 NA -23 0.137 Q9BQG0 M1208L Polymorphism 0.085 0.033 0.28 1 0.036 Q9BQI3 F292L Polymorphism NA 0.227 0.84 6 0.276 Q9BQI3 K132T Polymorphism 0.128 0.121 0.33 34 0.180 Q9BQI3 R134K Polymorphism 0.117 0.074 0.93 -3 0.087 Q9BQI3 R145H Polymorphism 0.073 0.039 0.32 -19 0.036 Q9BQI5 E112Q Polymorphism NA 0.264 0.05 15 0.377 Q9BQI5 K131R Polymorphism NA 0.043 0.56 -6 0.062 Q9BQI7 R31Q Polymorphism NA 0.114 0.00 -23 0.012 Q9BQI7 R51M Polymorphism NA 0.146 0.06 34 0.063 Q9BQK8 Q679H Polymorphism 0.068 0.206 0.25 -14 0.118 Q9BQL6 A534T Polymorphism 0.478 0.159 0.26 -6 0.212 Q9BQL6 I160T Polymorphism 0.122 0.193 0.20 -20 0.140 Q9BQL6 R526K Polymorphism 0.134 0.056 1.00 -20 0.015 Q9BQM9 Q62R Polymorphism NA 0.040 NA -40 0.018 Q9BQN1 E134K Polymorphism 0.410 0.220 0.35 21 0.361 Q9BQN1 Y600H Polymorphism 0.354 0.077 NA 23 0.065 Q9BQP7 S15C Polymorphism NA 0.149 NA 30 0.142 Q9BQP9 A41E Polymorphism 0.548 0.334 0.64 19 0.254 Q9BQQ3 T425M Polymorphism 0.221 0.052 0.04 -9 0.018 Q9BQS6 Q2P Polymorphism NA 0.400 0.00 26 0.247 Q9BQS8 R282H Polymorphism 0.286 0.088 0.05 -6 0.084 Q9BQS8 R447C Polymorphism 0.577 0.032 0.04 34 0.110 Q9BQS8 T381M Polymorphism 0.083 0.036 0.01 -65 0.081 Q9BQT8 W299C Polymorphism 0.488 0.948 0.00 52 0.899 Q9BQT9 S209G Polymorphism 0.112 0.117 0.47 -28 0.050 Q9BR10 P94L Polymorphism NA 0.437 NA 29 0.295 Q9BR76 R476L Polymorphism 0.402 0.399 0.05 6 0.405 Q9BRB3 T14A Polymorphism 0.129 0.038 NA -3 0.027 Q9BRD0 R120C Polymorphism NA 0.283 0.11 21 0.274 Q9BRD0 R242I Polymorphism NA 0.509 0.03 53 0.752 Q9BRF8 V86I Polymorphism NA 0.187 0.00 12 0.235 Q9BRG1 I76V Polymorphism 0.127 0.067 1.00 -44 0.028 Q9BRJ9 A53P Polymorphism NA 0.066 0.26 -25 0.011 Q9BRK4 R299W Polymorphism NA 0.353 0.11 59 0.650 Q9BRK5 N50D Polymorphism 0.234 0.106 0.30 -18 0.094 Q9BRP4 A53V Polymorphism NA 0.163 0.24 13 0.239 Q9BRP4 C139S Polymorphism 0.767 0.572 0.88 -6 0.595 Q9BRP8 E66Q Polymorphism 0.374 0.200 0.43 -27 0.355 Q9BRQ3 G36C Polymorphism NA 0.291 0.03 7 0.418 Q9BRQ3 T129R Polymorphism NA 0.925 0.00 55 0.911 Q9BRQ6 A95S Polymorphism 0.416 0.164 0.00 -23 0.157 Q9BRQ8 M135T Polymorphism 0.189 0.575 0.40 10 0.238 Q9BRR0 R3T Polymorphism 0.575 0.089 0.82 -21 0.079 Q9BRR0 F34L Polymorphism 0.080 0.097 0.94 -34 0.070 Q9BRR0 G33V Polymorphism 0.177 0.098 0.17 -3 0.177 Q9BRR0 H246Q Polymorphism 0.151 0.353 0.33 25 0.329 Q9BRR0 K200A Polymorphism 0.097 0.096 0.76 11 0.113 Q9BRR0 K200E Polymorphism 0.098 0.174 1.00 -6 0.090 Q9BRR0 K200T Polymorphism 0.091 0.187 0.49 -4 0.156 Q9BRR8 E909K Polymorphism NA 0.048 0.28 6 0.035 Q9BRR8 H724R Polymorphism 0.053 0.022 0.68 -23 0.045 Q9BRR8 L476P Polymorphism 0.120 0.669 0.36 -30 0.209 Q9BRR8 L728S Polymorphism 0.060 0.080 0.70 -34 0.023 Q9BRR9 R137C Polymorphism NA 0.092 0.00 41 0.155 Q9BRU9 H170R Polymorphism 0.221 0.081 0.22 22 0.151 Q9BRU9 K195Q Polymorphism 0.386 0.622 0.07 33 0.577 Q9BRU9 P215L Polymorphism 0.327 0.152 0.18 -18 0.248 Q9BRX9 G278S Polymorphism 0.146 0.720 0.57 -30 0.188 Q9BRY0 P257L Polymorphism 0.182 0.051 0.33 27 0.123 Q9BS31 A469T Polymorphism NA 0.090 0.33 10 0.178 Q9BS31 G352D Polymorphism 0.673 0.577 0.04 51 0.881 Q9BS40 H53R Polymorphism NA 0.128 0.06 16 0.131 Q9BS91 N247I Polymorphism 0.207 0.363 0.00 -6 0.440 Q9BS92 A159G Polymorphism 0.502 0.384 0.53 3 0.425 Q9BS92 K154E Polymorphism 0.499 0.774 0.07 46 0.768 Q9BSA4 D423E Polymorphism 0.153 0.672 0.10 -8 0.315 Q9BSA9 Q65P Polymorphism NA 0.380 0.09 48 0.490 Q9BSD7 G106E Polymorphism 0.154 0.111 0.30 -7 0.110 Q9BSE5 G105R Polymorphism 0.302 0.534 0.89 -10 0.334 Q9BSF8 T145A Polymorphism 0.128 0.091 NA -27 0.047 Q9BSG5 G198A Polymorphism 0.231 0.065 1.00 -32 0.009 Q9BSH4 G145S Polymorphism 0.774 0.891 0.00 43 0.742 Q9BSI4 A43T Polymorphism NA 0.325 NA 0 0.192 Q9BSI4 K280E Disease NA 0.538 NA 30 0.710 Q9BSI4 P241S Polymorphism NA 0.168 NA 35 0.212 Q9BSI4 R282H Disease NA 0.447 NA 37 0.215 Q9BSI4 R282S Disease NA 0.458 NA 30 0.337 Q9BSJ2 A111T Polymorphism NA 0.104 0.08 -50 0.053 Q9BSJ2 A809T Polymorphism 0.120 0.058 0.60 0 0.101 Q9BSJ5 F356L Polymorphism NA 0.520 NA 5 0.416 Q9BSJ6 S199C Polymorphism NA 0.076 NA 9 0.074 Q9BSK2 L242I Polymorphism 0.162 0.398 1.00 -42 0.229 Q9BSL1 E374D Polymorphism 0.412 0.500 0.00 6 0.446 Q9BSN7 G57A Polymorphism NA 0.074 0.00 9 0.075 Q9BSQ5 V53I Polymorphism 0.082 0.076 1.00 -50 0.084 Q9BSQ5 L198R Disease 0.570 0.732 0.00 55 0.847 Q9BSQ5 S289N Polymorphism 0.430 0.117 0.00 34 0.179 Q9BSQ5 V120I Polymorphism 0.166 0.141 0.36 -18 0.109 Q9BSU3 A6T Polymorphism 0.415 0.686 0.26 26 0.637 Q9BSV6 R58W Disease 0.767 0.463 0.19 35 0.640 Q9BSW2 A98T Polymorphism 0.362 0.192 0.60 -41 0.181 Q9BSW2 A128V Polymorphism 0.175 0.086 0.86 -10 0.134 Q9BSW2 E154K Polymorphism 0.101 0.192 0.50 46 0.200 Q9BSW2 H212Q Polymorphism 0.099 0.081 0.52 0 0.073 Q9BT09 M145I Polymorphism 0.271 0.438 0.08 34 0.511 Q9BT22 D429E Polymorphism 0.128 0.086 0.41 -52 0.113 Q9BT22 Q342P Disease 0.446 0.500 0.23 10 0.647 Q9BT22 Q455R Polymorphism 0.115 0.144 0.59 -34 0.103 Q9BT22 R438W Polymorphism 0.593 0.587 0.00 23 0.755 Q9BT22 S150R Disease 0.417 0.864 0.06 44 0.688 Q9BT22 S258L Disease 0.211 0.370 0.27 34 0.313 Q9BT22 S267N Polymorphism 0.118 0.158 0.46 -12 0.123 Q9BT30 R191Q Polymorphism 0.091 0.058 0.57 -1 0.066 Q9BT88 G231V Polymorphism 0.201 0.569 0.20 48 0.396 Q9BT92 E417K Polymorphism NA 0.082 0.87 7 0.089 Q9BT92 K127R Polymorphism NA 0.013 1.00 -32 0.027 Q9BTA9 T309A Polymorphism 0.065 0.051 0.25 24 0.050 Q9BTA9 T531S Polymorphism 0.152 0.184 0.50 22 0.175 Q9BTC0 P13L Polymorphism NA 0.107 NA 1 0.102 Q9BTC0 M544T Polymorphism 0.189 0.130 NA 18 0.049 Q9BTC0 P276L Polymorphism 0.353 0.662 0.00 47 0.672 Q9BTC0 P1220Q Polymorphism NA 0.044 0.00 -6 0.056 Q9BTL4 A133V Polymorphism 0.126 0.056 0.15 14 0.043 Q9BTP7 S126F Polymorphism NA 0.231 0.04 30 0.404 Q9BTP7 S158L Polymorphism NA 0.075 0.28 -4 0.067 Q9BTV4 A318V Polymorphism 0.183 0.222 NA -33 0.108 Q9BTV4 M179T Polymorphism 0.162 0.093 NA -17 0.041 Q9BTV4 S358L Disease 0.697 0.623 NA 11 0.663 Q9BTV6 G158R Polymorphism NA 0.072 0.72 18 0.080 Q9BTV7 T428K Polymorphism 0.360 0.068 1.00 -30 0.028 Q9BTW9 M617T Polymorphism 0.166 0.102 1.00 -26 0.083 Q9BTW9 S923N Polymorphism 0.228 0.134 0.42 -30 0.125 Q9BTW9 L1185P Polymorphism 0.401 0.656 0.00 23 0.509 Q9BTX1 G154D Polymorphism 0.163 0.095 0.88 -3 0.041 Q9BTX3 D82Y Polymorphism 0.258 0.377 0.06 34 0.507 Q9BTX3 L102P Polymorphism 0.762 0.810 0.05 42 0.841 Q9BU19 P230R Polymorphism NA 0.145 0.22 10 0.137 Q9BU20 E86G Polymorphism 0.180 0.597 0.18 58 0.689 Q9BU23 T479M Polymorphism NA 0.329 0.03 27 0.414 Q9BU61 G77R Disease 0.711 0.983 0.00 75 0.931 Q9BU61 R122P Disease 0.337 0.810 0.13 33 0.602 Q9BU70 S7P Polymorphism NA 0.071 0.10 -37 0.017 Q9BU70 V324M Polymorphism 0.439 0.068 0.00 47 0.134 Q9BUB4 H167N Polymorphism NA 0.048 0.53 -21 0.052 Q9BUB5 L158V Polymorphism 0.480 0.189 0.72 -26 0.222 Q9BUB7 D259E Polymorphism 0.151 0.021 1.00 -35 0.024 Q9BUD6 E122A Polymorphism 0.095 0.120 1.00 6 0.079 Q9BUD6 V242L Polymorphism 0.094 0.078 0.73 32 0.132 Q9BUI4 H243R Polymorphism 0.212 0.467 0.38 48 0.500 Q9BUK6 T324I Polymorphism 0.426 0.306 0.23 31 0.383 Q9BUL8 D102A Polymorphism 0.199 0.044 NA 10 0.083 Q9BUM1 G262R Disease 0.887 0.875 0.00 32 0.882 Q9BUM1 L185P Disease 0.681 0.724 0.06 45 0.777 Q9BUM1 R253H Disease 0.813 0.476 0.01 56 0.792 Q9BUN8 I171V Polymorphism 0.244 0.167 0.52 -46 0.126 Q9BUP0 K186R Polymorphism 0.193 0.175 0.46 -16 0.243 Q9BUR4 P11S Polymorphism 0.086 0.214 0.38 34 0.250 Q9BUR4 R68G Polymorphism 0.227 0.105 0.42 46 0.055 Q9BUR4 A522G Polymorphism 0.120 0.047 1.00 -47 0.018 Q9BUR4 E494Q Polymorphism 0.267 0.206 0.04 -4 0.309 Q9BUR4 N187T Polymorphism 0.153 0.194 0.09 -18 0.249 Q9BUR4 P136R Polymorphism 0.159 0.137 0.56 53 0.200 Q9BUT1 N70S Polymorphism 0.143 0.124 0.41 -52 0.123 Q9BUU2 A219T Polymorphism 0.163 0.069 0.25 -18 0.077 Q9BUV0 E239G Polymorphism NA 0.109 0.07 27 0.109 Q9BUV0 Y147H Polymorphism NA 0.488 0.42 32 0.610 Q9BUY5 A4V Polymorphism NA 0.076 1.00 -36 0.024 Q9BUY5 T219A Polymorphism 0.334 0.600 0.11 30 0.512 Q9BUY7 A15V Polymorphism NA 0.062 0.08 4 0.033 Q9BUZ4 R178G Polymorphism 0.607 0.458 0.38 52 0.566 Q9BV10 T67M Disease 0.989 0.822 0.01 59 0.956 Q9BV10 F142V Disease 0.416 0.929 0.02 44 0.818 Q9BV10 G101R Disease 0.803 0.574 0.39 13 0.742 Q9BV10 I393V Polymorphism 0.301 0.418 0.19 11 0.335 Q9BV10 L158P Disease 0.922 0.948 0.24 21 0.888 Q9BV10 R146Q Disease 0.877 0.925 0.00 58 0.943 Q9BV19 T178M Polymorphism 0.142 0.045 0.15 6 0.061 Q9BV29 K2I Polymorphism NA 0.165 NA 46 0.141 Q9BV36 R35W Disease NA 0.897 0.00 47 0.845 Q9BV36 G172D Polymorphism 0.080 0.079 0.03 5 0.097 Q9BV36 H347R Polymorphism 0.107 0.021 0.07 -13 0.056 Q9BV36 L153P Polymorphism 0.071 0.302 0.09 -37 0.185 Q9BV36 R139W Polymorphism 0.832 0.727 0.01 42 0.857 Q9BV38 A172T Polymorphism 0.330 0.161 1.00 -51 0.125 Q9BV44 R459Q Polymorphism NA 0.106 0.41 6 0.165 Q9BV73 Q995H Polymorphism 0.473 0.090 0.29 23 0.169 Q9BV73 Q1072E Polymorphism 0.243 0.047 1.00 15 0.061 Q9BV79 R227K Polymorphism NA 0.168 0.88 -36 0.189 Q9BV79 R258L Polymorphism 0.372 0.822 0.02 33 0.637 Q9BV87 P366L Polymorphism 0.514 0.507 0.00 4 0.573 Q9BV94 L556F Polymorphism 0.284 0.088 NA 8 0.066 Q9BV94 R510Q Polymorphism 0.061 0.232 0.32 25 0.165 Q9BV99 N143S Polymorphism 0.306 0.116 0.57 4 0.046 Q9BVC3 H376R Polymorphism 0.406 0.067 1.00 5 0.021 Q9BVC5 G185D Polymorphism NA 0.077 0.61 23 0.052 Q9BVG8 G391V Polymorphism NA 0.174 0.30 -5 0.239 Q9BVI0 V605M Polymorphism 0.228 0.071 0.02 25 0.102 Q9BVJ6 V487A Polymorphism 0.159 0.105 0.53 -10 0.084 Q9BVJ7 E124V Polymorphism 0.276 0.382 0.49 8 0.367 Q9BVK2 T47P Disease 0.871 0.983 0.00 65 0.947 Q9BVK2 G275D Disease 0.982 0.942 0.00 69 0.960 Q9BVK2 I439T Polymorphism 0.439 0.175 0.06 -43 0.264 Q9BVK2 N222S Polymorphism 0.209 0.241 0.54 -30 0.227 Q9BVK8 Y132H Polymorphism 0.627 0.643 0.00 52 0.623 Q9BVL2 A34T Polymorphism 0.134 0.148 0.08 46 0.113 Q9BVL2 S166P Polymorphism 0.543 0.301 0.26 25 0.535 Q9BVN2 S362F Polymorphism 0.397 0.082 0.22 2 0.061 Q9BVN2 V493A Polymorphism 0.077 0.053 0.93 -27 0.017 Q9BVP2 R39Q Polymorphism NA 0.168 0.53 3 0.210 Q9BVP2 V367M Polymorphism 0.100 0.375 0.13 -58 0.031 Q9BVQ7 N592D Polymorphism 0.180 0.701 0.01 41 0.578 Q9BVR0 L759P Polymorphism 0.830 0.214 0.15 8 0.153 Q9BVS4 S96C Polymorphism 0.852 0.562 0.01 34 0.802 Q9BVS4 E409D Polymorphism 0.197 0.101 0.05 -26 0.080 Q9BVS4 H144R Polymorphism 0.204 0.500 0.34 8 0.336 Q9BVS4 R155H Polymorphism 0.793 0.865 0.00 26 0.867 Q9BVS4 R507H Polymorphism 0.440 0.325 NA 13 0.505 Q9BVS4 V175I Polymorphism 0.390 0.671 0.07 24 0.564 Q9BVW5 A111G Polymorphism 0.578 0.368 0.42 13 0.468 Q9BVW5 N270S Polymorphism 0.069 0.033 0.94 -11 0.036 Q9BVX2 V103F Polymorphism NA 0.605 0.17 -3 0.473 Q9BW04 P87S Polymorphism 0.395 0.126 0.00 15 0.145 Q9BW04 N157T Polymorphism 0.126 0.041 0.59 -20 0.015 Q9BW04 R258G Polymorphism 0.249 0.066 0.39 7 0.025 Q9BW11 Q114H Polymorphism 0.387 0.084 0.26 -14 0.179 Q9BW19 R219Q Polymorphism NA 0.105 0.58 -24 0.133 Q9BW66 R164H Polymorphism NA 0.129 0.39 -8 0.106 Q9BW71 G521W Polymorphism 0.894 0.347 NA 36 0.551 Q9BWE0 A97V Polymorphism 0.144 0.559 0.56 -7 0.153 Q9BWH6 K165M Polymorphism 0.530 0.100 0.01 20 0.165 Q9BWH6 R582G Polymorphism 0.470 0.216 0.00 17 0.376 Q9BWS9 R331Q Polymorphism 0.206 0.046 0.32 9 0.110 Q9BWT7 R289Q Polymorphism 0.082 0.054 0.35 22 0.096 Q9BWV1 K883N Polymorphism 0.228 0.236 0.61 53 0.367 Q9BWV1 Q915H Polymorphism 0.463 0.168 0.06 48 0.199 Q9BWV2 K209E Polymorphism NA 0.215 NA 40 0.116 Q9BWV7 G3R Polymorphism NA 0.227 NA 48 0.078 Q9BWV7 P63S Polymorphism NA 0.149 0.03 4 0.026 Q9BWV7 I356V Polymorphism 0.210 0.588 1.00 -49 0.272 Q9BWV7 T127A Polymorphism 0.208 0.241 0.49 14 0.274 Q9BWW8 N173K Polymorphism 0.059 0.595 0.76 -10 0.180 Q9BWW9 S406C Polymorphism NA 0.122 NA 31 0.050 Q9BWW9 T272M Polymorphism 0.561 0.261 0.04 34 0.550 Q9BX26 P523L Polymorphism 0.541 0.101 NA 7 0.117 Q9BX26 T353K Polymorphism 0.539 0.162 0.16 33 0.159 Q9BX26 T751I Polymorphism 0.366 0.516 0.00 14 0.658 Q9BX59 G151R Polymorphism NA 0.362 0.04 50 0.553 Q9BX59 T334M Polymorphism NA 0.398 0.15 18 0.415 Q9BX63 P47A Disease 0.953 0.580 0.02 4 0.793 Q9BX63 A349P Disease 0.394 0.811 0.08 17 0.577 Q9BX63 C832Y Polymorphism 0.863 0.874 0.01 39 0.893 Q9BX63 F531V Polymorphism NA 0.520 0.34 39 0.519 Q9BX63 I633M Polymorphism 0.255 0.603 0.06 38 0.437 Q9BX63 L195P Polymorphism NA 0.342 0.10 19 0.268 Q9BX63 M299I Disease 0.172 0.352 0.49 13 0.180 Q9BX63 P919S Polymorphism NA 0.133 0.64 -11 0.072 Q9BX63 Q255H Disease 0.976 0.920 0.00 60 0.950 Q9BX63 Q540L Polymorphism NA 0.315 0.31 1 0.207 Q9BX63 R173C Polymorphism NA 0.454 0.02 32 0.583 Q9BX63 R264W Polymorphism 0.876 0.915 0.00 29 0.916 Q9BX63 R419W Polymorphism 0.701 0.563 0.02 29 0.755 Q9BX63 R707C Disease 0.278 0.492 0.10 40 0.415 Q9BX63 V193I Polymorphism NA 0.051 0.37 -34 0.080 Q9BX63 V935G Polymorphism NA 0.173 0.46 6 0.113 Q9BX63 W647C Disease 0.842 0.682 0.17 48 0.814 Q9BX63 D1148E Polymorphism NA 0.061 1.00 -61 0.007 Q9BX66 R74W Polymorphism 0.955 0.261 NA 2 0.412 Q9BX66 G175V Polymorphism 0.343 0.180 NA 28 0.212 Q9BX66 Y485C Polymorphism 0.770 0.119 0.01 -16 0.154 Q9BX69 R93K Polymorphism 0.074 0.033 0.14 -12 0.025 Q9BX69 D426V Polymorphism 0.696 0.473 0.04 21 0.667 Q9BX79 P90L Disease 0.605 0.688 0.00 44 0.768 Q9BX79 G339S Polymorphism 0.126 0.350 0.00 -3 0.224 Q9BX79 M527I Polymorphism 0.077 0.175 1.00 -23 0.071 Q9BX79 P293L Disease 0.615 0.621 0.00 38 0.743 Q9BX79 R655C Disease 0.797 0.854 0.00 67 0.946 Q9BX79 T321P Disease 0.546 0.732 0.00 44 0.814 Q9BX79 T644M Disease 0.628 0.706 0.00 52 0.625 Q9BX82 G406D Polymorphism 0.345 0.745 0.34 58 0.475 Q9BX82 M192I Polymorphism 0.423 0.453 0.47 2 0.348 Q9BX82 S556C Polymorphism 0.958 0.819 0.01 33 0.923 Q9BX84 F948L Polymorphism 0.261 0.803 0.42 26 0.538 Q9BX84 S141L Disease 0.963 0.953 0.00 35 0.933 Q9BX84 H1243R Polymorphism 0.276 0.105 0.05 43 0.141 Q9BX84 K1584E Polymorphism NA 0.264 NA 30 0.189 Q9BX84 N1071D Polymorphism 0.809 0.852 0.35 52 0.803 Q9BXA7 A50T Polymorphism NA 0.156 0.53 -18 0.139 Q9BXA7 H83Y Polymorphism 0.187 0.379 0.01 11 0.366 Q9BXA7 G288W Polymorphism 0.101 0.167 0.02 36 0.236 Q9BXA7 G293E Polymorphism 0.039 0.106 0.82 24 0.083 Q9BXA7 R237C Polymorphism 0.751 0.414 0.08 25 0.578 Q9BXA7 V233L Polymorphism 0.187 0.212 1.00 3 0.174 Q9BXA9 T533A Polymorphism 0.215 0.130 0.28 29 0.269 Q9BXB1 D844G Polymorphism NA 0.476 0.00 44 0.536 Q9BXB1 N233S Polymorphism 0.082 0.382 0.22 49 0.245 Q9BXB1 S215G Polymorphism 0.104 0.192 0.24 31 0.260 Q9BXB7 E90G Polymorphism NA 0.097 NA 39 0.062 Q9BXB7 N50S Polymorphism NA 0.022 NA 4 0.033 Q9BXB7 Q564R Polymorphism NA 0.098 NA 38 0.111 Q9BXB7 R283Q Disease NA 0.429 NA 22 0.317 Q9BXB7 V423M Polymorphism NA 0.069 NA 29 0.056 Q9BXC0 H43Q Polymorphism 0.773 0.294 0.53 32 0.609 Q9BXC1 S162P Polymorphism 0.317 0.639 0.26 16 0.419 Q9BXC9 N70S Disease NA 0.373 NA 27 0.280 Q9BXC9 R23P Disease NA 0.848 NA 36 0.768 Q9BXC9 V75G Disease NA 0.641 NA 15 0.664 Q9BXC9 A504V Polymorphism NA 0.231 NA 13 0.337 Q9BXC9 D104A Disease NA 0.604 NA 47 0.722 Q9BXC9 D174E Disease NA 0.500 NA 45 0.574 Q9BXC9 L349W Disease NA 0.387 NA 18 0.499 Q9BXC9 R315Q Disease NA 0.684 NA 48 0.643 Q9BXC9 R315W Disease NA 0.835 NA 52 0.807 Q9BXC9 R632P Disease NA 0.916 NA 69 0.925 Q9BXC9 R643H Disease NA 0.110 NA -13 0.170 Q9BXC9 T558I Disease NA 0.466 NA 25 0.558 Q9BXF3 R293H Polymorphism NA 0.144 0.00 27 0.163 Q9BXF9 R3H Polymorphism NA 0.058 0.38 -37 0.060 Q9BXF9 E410D Polymorphism 0.817 0.906 0.00 31 0.741 Q9BXF9 G282A Polymorphism 0.141 0.316 0.62 -8 0.152 Q9BXF9 V296A Polymorphism 0.327 0.213 0.09 5 0.314 Q9BXG8 E302K Polymorphism 0.321 0.035 0.64 1 0.078 Q9BXI2 G159C Polymorphism 0.457 0.697 0.06 -15 0.693 Q9BXI2 V181G Polymorphism 0.279 0.252 0.35 0 0.309 Q9BXI2 V226I Polymorphism 0.123 0.047 0.53 -31 0.095 Q9BXI6 R411H Polymorphism 0.134 0.101 0.13 23 0.082 Q9BXI9 G2V Polymorphism NA 0.093 0.00 20 0.161 Q9BXI9 P23R Polymorphism 0.168 0.118 0.06 29 0.100 Q9BXJ0 Q44R Polymorphism 0.287 0.387 0.62 0 0.184 Q9BXJ0 S163R Disease 0.451 0.789 0.14 10 0.693 Q9BXJ7 T41I Disease 0.159 0.281 NA -13 0.191 Q9BXJ8 Q86R Polymorphism 0.163 0.054 0.26 -16 0.111 Q9BXK5 I46R Polymorphism 0.208 0.079 NA 36 0.083 Q9BXK5 I46T Polymorphism 0.249 0.072 NA -13 0.039 Q9BXK5 I55V Polymorphism 0.066 0.023 NA -56 0.050 Q9BXK5 P360S Polymorphism 0.156 0.219 0.00 -31 0.156 Q9BXL7 S694L Polymorphism 0.441 0.242 0.19 24 0.357 Q9BXM0 A406T Polymorphism 0.128 0.117 0.72 -50 0.110 Q9BXM0 E495Q Polymorphism NA 0.133 0.50 -33 0.195 Q9BXM0 K935E Polymorphism 0.261 0.290 0.13 24 0.356 Q9BXM0 E1259K Polymorphism 0.356 0.312 0.27 33 0.321 Q9BXM0 P1083R Polymorphism 0.632 0.687 0.06 35 0.781 Q9BXM0 R1411C Polymorphism 0.792 0.154 0.01 46 0.450 Q9BXM7 C92F Disease NA 0.386 NA 39 0.264 Q9BXM7 A168P Disease 0.512 0.764 0.00 63 0.889 Q9BXM7 A217D Disease 0.306 0.873 0.08 51 0.851 Q9BXM7 A340T Polymorphism 0.058 0.048 0.39 -4 0.027 Q9BXM7 A383T Polymorphism 0.135 0.086 0.27 -21 0.071 Q9BXM7 C388R Disease 0.537 0.942 0.03 59 0.904 Q9BXM7 D362H Polymorphism 0.604 0.912 0.00 80 0.921 Q9BXM7 E240K Disease 0.091 0.832 0.06 59 0.805 Q9BXM7 E417G Disease 0.788 0.758 0.00 59 0.905 Q9BXM7 G309D Disease 0.094 0.915 0.34 14 0.175 Q9BXM7 H271Q Disease 0.273 0.718 0.31 70 0.883 Q9BXM7 L148W Polymorphism 0.345 0.066 0.01 -8 0.059 Q9BXM7 L268V Disease 0.123 0.290 0.28 17 0.207 Q9BXM7 L347P Disease 0.664 0.955 0.00 54 0.904 Q9BXM7 L461S Polymorphism 0.398 0.819 0.03 23 0.756 Q9BXM7 L489P Disease 0.541 0.850 0.00 64 0.902 Q9BXM7 M318L Polymorphism 0.292 0.910 0.31 43 0.667 Q9BXM7 M341I Polymorphism 0.056 0.196 0.37 -14 0.229 Q9BXM7 N235I Polymorphism 0.118 0.106 0.02 26 0.153 Q9BXM7 N521T Polymorphism 0.069 0.203 0.11 7 0.237 Q9BXM7 P196L Disease 0.337 0.166 0.00 20 0.220 Q9BXM7 P209L Polymorphism 0.144 0.128 0.07 14 0.101 Q9BXM7 P305L Polymorphism 0.182 0.795 0.64 35 0.592 Q9BXM7 Q115L Polymorphism 0.250 0.153 0.00 15 0.062 Q9BXM7 R147H Disease 0.172 0.298 0.01 26 0.216 Q9BXM7 R279H Disease 0.207 0.302 0.04 13 0.248 Q9BXM7 R464H Disease 0.415 0.221 0.02 14 0.362 Q9BXM7 T313M Disease 0.609 0.585 0.17 44 0.754 Q9BXN2 I223S Polymorphism 0.456 0.748 0.23 31 0.573 Q9BXR5 G381D Polymorphism 0.122 0.765 0.11 34 0.243 Q9BXR5 I775F Polymorphism 0.404 0.838 0.23 -18 0.534 Q9BXR5 M326T Polymorphism NA 0.420 0.42 55 0.604 Q9BXR5 R799P Polymorphism NA 0.285 NA 41 0.160 Q9BXR5 R799Q Polymorphism NA 0.136 NA 8 0.024 Q9BXR5 Y736C Polymorphism 0.791 0.849 0.02 53 0.905 Q9BXR6 L529R Polymorphism 0.739 0.598 0.53 38 0.735 Q9BXR6 R356H Polymorphism 0.367 0.221 0.06 38 0.228 Q9BXS6 T33A Polymorphism NA 0.169 0.08 -17 0.158 Q9BXT4 V864L Polymorphism 0.419 0.161 0.48 -46 0.140 Q9BXT6 M57L Polymorphism 0.076 0.088 0.16 -44 0.039 Q9BXT6 I454L Polymorphism NA 0.069 1.00 -35 0.073 Q9BXT6 Q820R Polymorphism NA 0.187 0.54 1 0.176 Q9BXT6 R182C Polymorphism 0.520 0.347 0.00 -17 0.553 Q9BXT6 S683G Polymorphism NA 0.096 0.07 43 0.171 Q9BXT6 V650I Polymorphism NA 0.163 0.29 24 0.167 Q9BXT8 K346N Polymorphism NA 0.270 0.00 40 0.149 Q9BXT8 S501G Polymorphism NA 0.140 0.00 -8 0.123 Q9BXT8 E1380K Polymorphism 0.049 0.065 0.02 36 0.087 Q9BXT8 N1110K Polymorphism 0.280 0.153 1.00 -10 0.088 Q9BXU1 Q71H Polymorphism NA 0.055 0.00 32 0.049 Q9BXU1 A393T Polymorphism NA 0.227 NA 34 0.209 Q9BXU1 A600T Polymorphism NA 0.055 NA 11 0.033 Q9BXU1 E709K Polymorphism NA 0.476 0.02 26 0.476 Q9BXU1 G410E Polymorphism NA 0.105 NA -3 0.017 Q9BXU1 T362P Polymorphism NA 0.311 NA 36 0.225 Q9BXU1 T1010S Polymorphism NA 0.159 0.00 17 0.170 Q9BXW6 S810P Polymorphism NA 0.508 0.08 -17 0.470 Q9BXW7 R369S Polymorphism 0.097 0.110 NA -5 0.101 Q9BXW9 K33R Polymorphism NA 0.025 NA 27 0.094 Q9BXW9 Q65H Polymorphism NA 0.123 NA 28 0.112 Q9BXW9 T61M Polymorphism NA 0.118 NA 31 0.122 Q9BXW9 G901V Polymorphism NA 0.138 NA 23 0.124 Q9BXW9 I172M Polymorphism NA 0.086 NA -41 0.080 Q9BXW9 K865R Polymorphism NA 0.086 NA 22 0.102 Q9BXW9 L446V Polymorphism NA 0.086 NA -2 0.125 Q9BXW9 P714L Polymorphism NA 0.077 NA 7 0.082 Q9BXW9 R302W Disease NA 0.846 NA 52 0.868 Q9BXW9 R328Q Polymorphism NA 0.061 NA 2 0.086 Q9BXW9 S126G Disease NA 0.049 NA 24 0.088 Q9BXW9 T193A Polymorphism NA 0.149 NA 8 0.132 Q9BXW9 R1236H Disease NA 0.550 NA 45 0.666 Q9BXX0 A215T Polymorphism 0.211 0.071 0.42 -25 0.066 Q9BXX3 R985C Polymorphism 0.155 0.238 0.01 34 0.290 Q9BXX3 T611A Polymorphism NA 0.133 0.47 25 0.105 Q9BXY0 Q277R Polymorphism 0.165 0.019 0.78 6 0.013 Q9BY07 S251N Polymorphism 0.129 0.201 0.17 -5 0.195 Q9BY11 A334V Polymorphism 0.390 0.108 0.30 5 0.158 Q9BY12 A1139T Polymorphism NA 0.039 NA -33 0.051 Q9BY12 P1088T Polymorphism NA 0.121 NA -12 0.114 Q9BY14 G99V Polymorphism NA 0.950 0.00 47 0.850 Q9BY15 A236V Polymorphism NA 0.375 0.23 11 0.343 Q9BY15 E127Q Polymorphism NA 0.084 0.57 14 0.146 Q9BY27 N195K Polymorphism 0.170 0.099 1.00 5 0.033 Q9BY32 P32T Disease 0.219 0.166 0.17 0 0.242 Q9BY43 G153R Polymorphism 0.483 0.852 0.01 19 0.806 Q9BY44 E582K Polymorphism 0.095 0.052 0.87 -38 0.064 Q9BY49 E149K Polymorphism 0.292 0.472 0.92 -17 0.205 Q9BY64 L365H Polymorphism 0.993 0.102 1.00 -48 0.092 Q9BY66 V1186L Polymorphism 0.066 0.193 0.29 -9 0.145 Q9BY76 P5L Polymorphism NA 0.290 0.00 7 0.222 Q9BY76 M41I Polymorphism 0.123 0.187 0.32 -31 0.170 Q9BY76 R72L Polymorphism 0.314 0.189 0.24 4 0.307 Q9BY76 S67R Polymorphism 0.081 0.067 0.62 -27 0.071 Q9BY76 E167K Polymorphism 0.054 0.221 0.97 -30 0.165 Q9BY76 E190Q Polymorphism 0.367 0.111 0.09 42 0.287 Q9BY76 F237V Polymorphism 0.392 0.919 0.00 64 0.748 Q9BY76 G233R Polymorphism 0.660 0.887 0.00 62 0.764 Q9BY76 G361R Polymorphism 0.873 0.855 0.00 71 0.917 Q9BY76 R371Q Polymorphism 0.415 0.219 0.51 19 0.368 Q9BY76 R384W Polymorphism 0.543 0.835 0.00 57 0.900 Q9BY76 V308M Polymorphism 0.107 0.612 0.08 55 0.619 Q9BY76 W349C Polymorphism 0.935 0.930 0.00 72 0.778 Q9BY79 I182T Disease 0.109 0.490 0.00 36 0.516 Q9BY79 Q514H Polymorphism 0.071 0.411 0.08 45 0.389 Q9BY79 V136M Polymorphism NA 0.321 0.13 -23 0.195 Q9BY84 V366M Polymorphism 0.245 0.105 0.09 29 0.089 Q9BYB0 A224T Polymorphism 0.295 0.366 0.01 34 0.463 Q9BYB4 E30K Polymorphism NA 0.148 0.19 26 0.267 Q9BYC2 E250D Polymorphism 0.146 0.566 0.61 -29 0.229 Q9BYD2 E67G Polymorphism 0.378 0.349 0.01 10 0.406 Q9BYD2 E210A Polymorphism NA 0.264 0.02 12 0.363 Q9BYD9 E234K Polymorphism 0.338 0.576 0.17 10 0.466 Q9BYE3 G43V Polymorphism NA 0.213 0.24 36 0.024 Q9BYE9 A415G Polymorphism NA 0.200 0.37 0 0.177 Q9BYE9 L766P Polymorphism 0.676 0.367 0.00 18 0.549 Q9BYE9 Q107H Polymorphism NA 0.148 0.00 13 0.312 Q9BYE9 T901M Polymorphism NA 0.226 0.15 24 0.404 Q9BYE9 V424A Polymorphism NA 0.237 0.77 -19 0.257 Q9BYE9 V948M Polymorphism NA 0.283 0.01 42 0.491 Q9BYF1 N638S Polymorphism 0.337 0.232 0.06 11 0.264 Q9BYG3 P144Q Polymorphism NA 0.359 0.15 -9 0.316 Q9BYG7 R39S Polymorphism 0.373 0.099 0.08 29 0.191 Q9BYG7 T134A Polymorphism 0.517 0.122 0.67 -13 0.121 Q9BYG8 R150K Polymorphism 0.088 0.095 0.90 -51 0.038 Q9BYH1 P52L Polymorphism NA 0.118 NA -3 0.016 Q9BYH1 M430I Polymorphism 0.145 0.306 0.21 -1 0.144 Q9BYH1 W185L Polymorphism NA 0.173 0.27 11 0.197 Q9BYH8 T307S Polymorphism NA 0.083 0.08 -12 0.019 Q9BYI3 L53P Disease NA 0.737 0.00 23 0.732 Q9BYJ0 F84L Polymorphism 0.241 0.114 0.74 34 0.102 Q9BYJ0 P90S Polymorphism 0.101 0.041 0.67 -3 0.021 Q9BYJ1 R396S Disease 0.934 0.557 0.02 22 0.844 Q9BYJ1 V500F Disease 0.739 0.696 0.04 43 0.786 Q9BYJ4 D282H Polymorphism 0.724 0.287 0.07 55 0.659 Q9BYK8 L1821R Polymorphism NA 0.120 NA 0 0.051 Q9BYK8 Q2049E Polymorphism NA 0.062 0.13 -15 0.012 Q9BYK8 R1381K Polymorphism 0.046 0.307 0.11 -41 0.121 Q9BYK8 S1152L Polymorphism NA 0.083 NA 18 0.141 Q9BYK8 V1308L Polymorphism 0.137 0.135 0.04 -8 0.117 Q9BYP7 Q704H Polymorphism 0.537 0.131 0.02 -16 0.103 Q9BYP9 C56S Polymorphism 0.760 0.445 0.14 54 0.543 Q9BYQ7 H66R Polymorphism 0.681 0.284 0.48 3 0.308 Q9BYR2 C6R Polymorphism 0.636 0.826 0.01 65 0.910 Q9BYR4 P152S Polymorphism 0.463 0.240 0.37 0 0.382 Q9BYR7 S8G Polymorphism 0.076 0.086 0.69 42 0.054 Q9BYR7 I46T Polymorphism 0.084 0.120 1.00 16 0.047 Q9BYS8 T83A Polymorphism NA 0.105 0.55 31 0.166 Q9BYS8 V32A Polymorphism NA 0.083 0.47 12 0.056 Q9BYT1 N228S Polymorphism 0.164 0.047 0.50 0 0.082 Q9BYT1 T397M Polymorphism 0.468 0.633 0.22 59 0.641 Q9BYT3 E98D Polymorphism NA 0.217 0.56 -4 0.220 Q9BYT8 S417G Polymorphism 0.319 0.649 0.03 -11 0.498 Q9BYT9 L781V Polymorphism 0.412 0.671 0.41 8 0.425 Q9BYU1 M177V Polymorphism 0.270 0.883 0.37 49 0.613 Q9BYV1 T212I Polymorphism 0.212 0.500 0.56 -1 0.269 Q9BYW1 D60N Polymorphism 0.239 0.286 0.40 19 0.319 Q9BYW1 R232Q Polymorphism 0.057 0.660 0.42 12 0.086 Q9BYW2 V768L Polymorphism 0.180 0.115 NA 20 0.092 Q9BYX2 L253S Polymorphism NA 0.078 0.03 15 0.092 Q9BYX4 A946T Polymorphism 0.320 0.067 0.52 -9 0.121 Q9BYZ2 V14M Polymorphism NA 0.091 0.02 -12 0.058 Q9BYZ2 I326T Polymorphism 0.250 0.442 0.08 25 0.394 Q9BYZ2 P259S Polymorphism 0.172 0.862 0.60 1 0.292 Q9BYZ8 N135H Polymorphism 0.255 0.146 0.03 7 0.180 Q9BZ11 A365S Polymorphism 0.129 0.151 0.69 -16 0.105 Q9BZ11 D441E Polymorphism 0.280 0.593 0.04 17 0.478 Q9BZ11 L612H Polymorphism 0.799 0.205 0.52 49 0.526 Q9BZ11 N109S Polymorphism 0.352 0.111 0.77 -15 0.148 Q9BZ11 P336S Polymorphism 0.487 0.558 1.00 -33 0.383 Q9BZ11 P774S Polymorphism 0.220 0.128 0.43 -15 0.103 Q9BZ11 T272M Polymorphism 0.624 0.261 0.07 54 0.669 Q9BZ11 V316I Polymorphism 0.172 0.138 0.30 35 0.200 Q9BZ11 V710I Polymorphism 0.124 0.098 0.85 -22 0.107 Q9BZ19 R295C Polymorphism 0.610 0.627 0.01 40 0.726 Q9BZ23 G126A Polymorphism NA 0.036 NA -38 0.013 Q9BZ23 G219V Disease NA 0.977 0.00 64 0.933 Q9BZ23 G521R Disease 0.943 0.961 0.00 78 0.950 Q9BZ23 I497T Disease 0.585 0.892 0.00 30 0.672 Q9BZ23 L111Q Polymorphism NA 0.179 NA 39 0.048 Q9BZ23 L282V Disease 0.419 0.830 0.01 43 0.762 Q9BZ23 L413P Disease 0.831 0.965 0.01 36 0.881 Q9BZ23 N355S Disease 0.269 0.447 0.02 -3 0.301 Q9BZ23 N404I Disease 0.654 0.585 0.04 11 0.733 Q9BZ23 N500I Disease 0.767 0.918 0.25 42 0.859 Q9BZ23 R264W Disease NA 0.733 0.02 38 0.782 Q9BZ23 R278C Disease 0.882 0.707 0.00 23 0.854 Q9BZ23 R286C Disease 0.835 0.632 0.00 33 0.784 Q9BZ23 S351P Disease NA 0.880 0.05 45 0.850 Q9BZ23 S471N Disease 0.784 0.852 0.37 27 0.757 Q9BZ23 T234A Disease NA 0.373 0.10 -5 0.271 Q9BZ23 T327I Disease 0.256 0.190 0.40 -33 0.283 Q9BZ23 T528M Disease 0.181 0.195 0.14 -40 0.151 Q9BZ29 K1416E Polymorphism 0.292 0.619 0.12 40 0.474 Q9BZ71 Q626H Disease 0.094 0.058 0.53 -30 0.068 Q9BZ72 P9L Polymorphism NA 0.343 0.39 6 0.305 Q9BZ76 A628S Polymorphism NA 0.483 0.30 -37 0.296 Q9BZ95 R383P Polymorphism 0.452 0.595 0.12 26 0.506 Q9BZA7 R1018Q Polymorphism NA 0.056 0.00 30 0.081 Q9BZA8 V917F Polymorphism 0.079 0.118 1.00 -18 0.028 Q9BZA8 A1320T Polymorphism NA 0.049 1.00 -37 0.011 Q9BZA8 N1012K Polymorphism 0.118 0.130 1.00 -6 0.055 Q9BZC1 G388S Polymorphism 0.147 0.404 0.14 32 0.270 Q9BZC7 H583P Polymorphism 0.101 0.259 0.35 0 0.129 Q9BZD2 R18G Polymorphism 0.396 0.169 0.59 25 0.142 Q9BZD2 G427S Disease 0.994 0.686 0.00 58 0.946 Q9BZD2 G437R Disease 0.696 0.712 0.05 65 0.899 Q9BZD2 S158F Polymorphism 0.339 0.749 0.16 41 0.681 Q9BZD2 V239I Polymorphism 0.178 0.146 0.85 0 0.129 Q9BZD4 S229L Polymorphism 0.325 0.130 0.32 1 0.098 Q9BZD6 E33K Polymorphism NA 0.048 0.95 -32 0.066 Q9BZD6 C143R Polymorphism 0.179 0.507 0.81 36 0.299 Q9BZD7 N153S Polymorphism 0.149 0.035 0.55 -14 0.039 Q9BZE0 T492A Polymorphism 0.191 0.128 0.39 0 0.069 Q9BZE1 C366S Polymorphism 0.267 0.054 1.00 -15 0.013 Q9BZE2 Y3D Polymorphism NA 0.330 0.54 -24 0.197 Q9BZE2 A46S Polymorphism NA 0.140 0.60 -54 0.102 Q9BZE2 E460D Polymorphism NA 0.192 0.00 3 0.256 Q9BZE9 V318M Polymorphism 0.483 0.343 0.03 36 0.408 Q9BZF2 M148I Polymorphism 0.195 0.151 1.00 -29 0.096 Q9BZF2 T156I Polymorphism 0.294 0.131 0.18 17 0.248 Q9BZF3 R53Q Polymorphism NA 0.099 0.44 34 0.072 Q9BZG8 I51M Polymorphism NA 0.617 0.09 -16 0.505 Q9BZG8 K226R Polymorphism 0.211 0.250 0.25 -49 0.279 Q9BZI7 Y160D Disease 0.979 0.974 0.17 56 0.973 Q9BZJ0 F51L Polymorphism NA 0.328 NA 10 0.117 Q9BZJ0 G35R Polymorphism NA 0.225 NA 43 0.071 Q9BZJ0 T158A Polymorphism NA 0.067 NA 23 0.060 Q9BZJ3 V83M Polymorphism 0.573 0.556 0.24 35 0.605 Q9BZL6 V324M Polymorphism 0.300 0.198 0.15 23 0.257 Q9BZM6 L101I Polymorphism NA 0.730 0.36 22 0.553 Q9BZP6 F377L Polymorphism 0.526 0.405 0.06 34 0.633 Q9BZP6 I339V Polymorphism 0.130 0.043 0.30 -44 0.102 Q9BZP6 V324G Polymorphism 0.933 0.378 0.28 9 0.651 Q9BZQ2 V563M Polymorphism 0.434 0.335 0.02 29 0.488 Q9BZQ8 D692N Polymorphism 0.290 0.131 0.49 4 0.041 Q9BZQ8 G830S Polymorphism 0.422 0.117 NA 16 0.107 Q9BZS1 A384T Disease 0.623 0.668 0.05 57 0.875 Q9BZS1 F371C Disease 0.998 0.890 0.00 68 0.948 Q9BZS1 I363V Disease 0.911 0.564 0.01 43 0.832 Q9BZS1 R397W Disease 0.996 0.924 0.00 54 0.948 Q9BZV2 G23V Disease 0.975 0.966 0.00 50 0.958 Q9BZV2 T422A Disease 0.828 0.884 0.00 36 0.884 Q9BZV3 K344N Polymorphism 0.498 0.132 0.26 31 0.127 Q9BZV3 T674I Polymorphism 0.196 0.067 0.65 -15 0.028 Q9BZV3 P1013L Polymorphism 0.819 0.637 0.12 23 0.708 Q9BZW2 I392T Polymorphism 0.690 0.415 0.03 -8 0.638 Q9BZW2 Q157E Polymorphism 0.215 0.295 1.00 8 0.309 Q9BZW2 T240M Polymorphism 0.450 0.158 0.67 -39 0.107 Q9BZW2 V332A Polymorphism 0.511 0.421 0.11 -11 0.574 Q9BZW2 Y205C Polymorphism NA 0.366 0.10 29 0.423 Q9BZW5 I17T Polymorphism NA 0.467 0.04 27 0.551 Q9BZW8 S323F Polymorphism 0.675 0.249 0.04 37 0.354 Q9BZY9 P17R Polymorphism 0.657 0.745 0.01 63 0.906 Q9BZY9 E421K Polymorphism NA 0.151 NA 16 0.058 Q9BZY9 R118C Polymorphism 0.164 0.724 0.05 50 0.297 Q9BZZ2 A974V Polymorphism NA 0.659 1.00 43 0.375 Q9BZZ2 H919P Polymorphism NA 0.756 0.28 29 0.400 Q9BZZ2 K239R Polymorphism 0.541 0.569 0.39 34 0.379 Q9BZZ2 R464H Polymorphism 0.617 0.598 0.23 54 0.542 Q9BZZ2 A1519P Polymorphism NA 0.819 0.72 38 0.693 Q9BZZ2 R1487W Polymorphism NA 0.847 0.02 56 0.785 Q9BZZ2 S1335Y Polymorphism NA 0.831 0.11 42 0.751 Q9BZZ5 G493S Polymorphism 0.148 0.219 0.22 -26 0.143 Q9BZZ5 M300V Polymorphism 0.232 0.069 0.08 6 0.093 Q9BZZ5 P276S Polymorphism 0.179 0.195 0.35 -35 0.165 Q9C000 L155H Polymorphism NA 0.231 0.10 33 0.131 Q9C000 R404Q Polymorphism 0.272 0.799 0.08 14 0.579 Q9C000 T246S Polymorphism NA 0.092 0.09 3 0.099 Q9C000 M1119V Polymorphism 0.127 0.132 0.00 -31 0.059 Q9C000 R1366C Polymorphism NA 0.213 NA 35 0.157 Q9C000 V1241L Polymorphism NA 0.120 NA -50 0.062 Q9C009 Q61P Polymorphism NA 0.182 0.26 11 0.062 Q9C019 A42T Polymorphism 0.163 0.117 0.60 -53 0.185 Q9C019 S324N Polymorphism 0.062 0.090 1.00 10 0.085 Q9C029 A18S Polymorphism NA 0.392 0.69 -34 0.252 Q9C029 V258A Polymorphism 0.081 0.241 0.37 4 0.112 Q9C035 H43Y Polymorphism 0.211 0.461 1.00 -11 0.177 Q9C035 G249D Polymorphism 0.149 0.181 0.87 -10 0.115 Q9C035 P479L Polymorphism 0.884 0.715 0.74 32 0.852 Q9C035 V112F Polymorphism 0.511 0.548 0.04 26 0.519 Q9C075 S393F Polymorphism 0.355 0.628 0.02 20 0.698 Q9C093 A904V Polymorphism NA 0.015 0.12 -44 0.019 Q9C093 A934P Polymorphism NA 0.111 0.10 34 0.016 Q9C093 R366K Polymorphism NA 0.387 0.00 30 0.430 Q9C098 E633D Polymorphism NA 0.182 0.06 34 0.242 Q9C0A0 Q513H Polymorphism 0.557 0.471 0.23 16 0.551 Q9C0A6 M1137V Polymorphism 0.470 0.041 NA 25 0.027 Q9C0B2 G628C Polymorphism NA 0.883 NA 45 0.796 Q9C0B2 I363V Polymorphism 0.181 0.026 0.68 -37 0.022 Q9C0B6 L390V Polymorphism NA 0.042 1.00 -43 0.006 Q9C0B9 T941A Polymorphism 0.240 0.127 0.09 28 0.052 Q9C0C2 S714N Polymorphism NA 0.121 0.03 3 0.154 Q9C0C6 T203A Polymorphism NA 0.032 0.40 -16 0.038 Q9C0C9 G1207S Polymorphism NA 0.074 NA 19 0.063 Q9C0D0 I247M Polymorphism 0.352 0.144 0.09 22 0.136 Q9C0D2 A499E Polymorphism 0.245 0.061 1.00 -28 0.009 Q9C0D2 E1026K Polymorphism 0.259 0.039 0.74 2 0.038 Q9C0D2 L1459R Polymorphism NA 0.259 0.30 40 0.154 Q9C0D4 S523N Polymorphism NA 0.023 NA 15 0.032 Q9C0D5 G1511S Polymorphism 0.142 0.037 1.00 32 0.026 Q9C0D5 T1573A Polymorphism NA 0.034 1.00 -23 0.012 Q9C0E2 T451A Polymorphism 0.145 0.089 0.36 21 0.095 Q9C0F0 V1652M Polymorphism 0.342 0.119 NA 22 0.032 Q9C0G0 N69S Polymorphism NA 0.056 0.00 12 0.110 Q9C0G0 G512R Polymorphism NA 0.055 0.12 53 0.030 Q9C0G0 N972T Polymorphism NA 0.111 0.01 22 0.143 Q9C0I3 G382S Polymorphism 0.451 0.120 0.00 18 0.082 Q9C0J1 L87P Polymorphism NA 0.411 0.17 45 0.325 Q9C0J8 A33S Polymorphism 0.141 0.315 0.00 1 0.420 Q9GZK3 A183P Polymorphism 0.726 0.598 0.51 8 0.621 Q9GZK3 Q234R Polymorphism 0.492 0.205 1.00 1 0.158 Q9GZK4 V223M Polymorphism 0.885 0.894 0.00 47 0.910 Q9GZL7 I75V Polymorphism 0.195 0.319 1.00 9 0.244 Q9GZL7 E286G Polymorphism 0.468 0.265 0.35 23 0.402 Q9GZM6 R122H Polymorphism 0.595 0.862 0.02 61 0.822 Q9GZN0 Q318H Polymorphism 0.142 0.277 0.53 28 0.151 Q9GZP0 I190V Polymorphism 0.103 0.081 0.18 -13 0.031 Q9GZP1 L41V Polymorphism NA 0.107 0.30 -13 0.090 Q9GZP1 S65C Polymorphism NA 0.127 0.11 -16 0.074 Q9GZP7 A269D Polymorphism 0.618 0.803 0.17 -55 0.442 Q9GZP7 I139T Polymorphism 0.855 0.670 1.00 -15 0.345 Q9GZP7 S241F Polymorphism 0.746 0.953 0.77 -10 0.580 Q9GZQ3 A6T Polymorphism 0.194 0.064 0.00 -4 0.137 Q9GZQ4 M388V Polymorphism 0.042 0.046 0.85 -10 0.028 Q9GZQ4 P383L Polymorphism 0.613 0.225 0.07 19 0.535 Q9GZQ4 S298T Polymorphism 0.071 0.286 1.00 -26 0.170 Q9GZR1 A820V Polymorphism 0.204 0.055 0.01 20 0.120 Q9GZR1 R717P Polymorphism 0.656 0.891 0.04 55 0.896 Q9GZR1 T121M Polymorphism 0.489 0.187 NA 29 0.334 Q9GZR1 Y1106C Polymorphism NA 0.059 NA 4 0.060 Q9GZR2 R141K Polymorphism NA 0.031 1.00 -40 0.034 Q9GZR5 I267T Polymorphism 0.797 0.317 0.19 -21 0.592 Q9GZS9 A311T Polymorphism 0.220 0.114 0.51 1 0.200 Q9GZT5 P302T Polymorphism 0.084 0.601 0.36 -14 0.026 Q9GZT8 T324I Polymorphism 0.265 0.223 0.45 15 0.056 Q9GZT9 P317R Disease 0.906 0.934 0.09 51 0.918 Q9GZT9 R371H Disease 0.715 0.953 0.04 49 0.874 Q9GZU0 R140S Polymorphism NA 0.227 NA 30 0.200 Q9GZU0 W116C Polymorphism NA 0.765 NA 48 0.794 Q9GZU1 D362Y Disease 0.954 0.983 0.02 58 0.948 Q9GZU1 F465L Disease 0.726 0.891 0.02 48 0.869 Q9GZU1 L106P Disease 0.952 0.988 0.00 45 0.736 Q9GZU1 L447P Disease 0.895 0.989 0.00 57 0.946 Q9GZU1 R403C Disease 0.963 0.987 0.00 50 0.959 Q9GZU1 T232P Disease 0.550 0.775 0.07 21 0.806 Q9GZU1 V446L Disease 0.426 0.878 0.22 -17 0.575 Q9GZU2 A235T Polymorphism NA 0.060 0.47 -3 0.066 Q9GZU2 D983G Polymorphism 0.291 0.302 0.56 57 0.354 Q9GZU2 E624G Polymorphism 0.343 0.186 0.01 40 0.427 Q9GZU2 N947S Polymorphism NA 0.184 0.40 13 0.278 Q9GZU2 V839L Polymorphism NA 0.323 0.43 24 0.242 Q9GZU2 R1576H Polymorphism NA 0.145 0.40 68 0.340 Q9GZU2 R1576L Polymorphism NA 0.295 0.56 68 0.576 Q9GZU5 C31S Disease 0.999 0.738 0.00 41 0.861 Q9GZU5 A143P Disease 0.573 0.601 0.34 42 0.782 Q9GZU5 A187K Disease NA 0.531 0.01 59 0.838 Q9GZU5 F298S Disease 0.899 0.848 0.00 55 0.963 Q9GZU5 G370V Disease 0.934 0.598 0.01 24 0.828 Q9GZU5 L184P Disease 0.949 0.864 0.00 67 0.972 Q9GZU5 L213Q Disease 0.691 0.500 0.00 61 0.935 Q9GZU5 L232P Disease 0.703 0.706 0.00 81 0.939 Q9GZU5 L285P Disease 0.975 0.836 0.00 55 0.982 Q9GZU5 L307P Disease 0.749 0.881 0.00 61 0.931 Q9GZU5 L347P Disease 0.949 0.835 0.00 53 0.921 Q9GZU5 N216S Disease 0.700 0.456 0.18 50 0.665 Q9GZU5 N264K Disease 0.978 0.592 0.00 59 0.936 Q9GZU5 N312S Disease 0.965 0.862 0.00 59 0.887 Q9GZU5 P151L Disease 0.643 0.708 0.17 30 0.615 Q9GZU5 P175R Disease 0.348 0.798 0.05 41 0.646 Q9GZV9 S71G Disease 0.640 0.454 0.15 30 0.566 Q9GZV9 P195S Polymorphism 0.728 0.240 0.14 -7 0.383 Q9GZV9 R176Q Disease 0.431 0.065 0.13 12 0.100 Q9GZV9 R179Q Disease 0.431 0.155 0.02 4 0.174 Q9GZV9 R179W Disease 0.850 0.239 0.00 40 0.497 Q9GZW5 P110T Polymorphism 0.661 0.868 0.00 37 0.807 Q9GZW8 P112H Polymorphism 0.704 0.190 0.54 25 0.329 Q9GZX3 G52D Disease 0.972 0.968 0.00 77 0.959 Q9GZX3 H42Y Disease 0.672 0.719 0.02 48 0.853 Q9GZX3 L15P Disease 0.775 0.554 0.00 22 0.661 Q9GZX3 L22R Disease 0.744 0.612 0.19 28 0.634 Q9GZX3 L59P Disease 0.837 0.960 0.01 56 0.928 Q9GZX3 M70L Disease 0.276 0.500 0.10 44 0.617 Q9GZX3 N61T Disease 0.128 0.929 0.03 45 0.686 Q9GZX3 P31S Disease 0.086 0.133 0.46 -26 0.080 Q9GZX3 P72S Disease 0.972 0.917 0.00 51 0.956 Q9GZX3 R50C Disease 0.985 0.940 0.00 84 0.960 Q9GZX3 R93H Disease 0.969 0.821 0.00 55 0.942 Q9GZX3 R97P Disease 0.804 0.864 0.02 56 0.872 Q9GZX3 S51L Disease 0.698 0.906 0.01 66 0.879 Q9GZX3 S53L Disease 0.954 0.947 0.00 64 0.953 Q9GZX3 S98W Disease 0.915 0.599 0.00 24 0.768 Q9GZX3 V66L Disease 0.648 0.523 0.03 45 0.638 Q9GZX3 V76M Disease 0.665 0.554 0.01 40 0.702 Q9GZX3 Y68H Disease 0.705 0.932 0.00 75 0.937 Q9GZX3 A128V Disease 0.596 0.239 0.77 15 0.486 Q9GZX3 A206T Disease 0.776 0.809 0.01 56 0.901 Q9GZX3 A206V Disease 0.836 0.771 0.01 55 0.917 Q9GZX3 A217T Disease 0.147 0.131 0.68 12 0.177 Q9GZX3 C102G Disease 0.959 0.967 0.00 48 0.931 Q9GZX3 C102Y Disease 0.989 0.979 0.00 58 0.952 Q9GZX3 D203E Disease 0.912 0.932 0.00 65 0.946 Q9GZX3 D221E Disease 0.470 0.197 1.00 18 0.241 Q9GZX3 D221Y Disease 0.870 0.605 0.17 62 0.879 Q9GZX3 E274K Disease 0.956 0.962 0.00 70 0.966 Q9GZX3 F107S Disease 0.755 0.670 0.01 47 0.783 Q9GZX3 F121L Disease 0.888 0.864 0.00 43 0.834 Q9GZX3 H249P Disease 0.510 0.696 0.21 55 0.841 Q9GZX3 K174R Disease 0.841 0.884 0.00 55 0.926 Q9GZX3 L152P Disease 0.837 0.713 0.29 49 0.882 Q9GZX3 L200R Disease 0.978 0.990 0.00 62 0.959 Q9GZX3 L276P Disease 0.813 0.960 0.00 49 0.911 Q9GZX3 M104V Disease 0.436 0.306 0.04 29 0.408 Q9GZX3 P204Q Disease 0.988 0.940 0.00 64 0.969 Q9GZX3 Q122P Disease 0.585 0.601 0.06 51 0.568 Q9GZX3 R127C Disease 0.901 0.621 0.00 63 0.907 Q9GZX3 R162G Disease 0.295 0.328 0.35 26 0.146 Q9GZX3 R166P Disease 0.531 0.924 0.01 33 0.860 Q9GZX3 R177H Disease 0.969 0.943 0.01 60 0.963 Q9GZX3 R202S Disease 0.968 0.968 0.00 75 0.965 Q9GZX3 R205L Disease 0.971 0.984 0.00 69 0.963 Q9GZX3 R205Q Disease 0.957 0.941 0.00 73 0.964 Q9GZX3 R211Q Disease 0.957 0.889 0.02 71 0.956 Q9GZX3 R211W Disease 0.992 0.934 0.00 70 0.965 Q9GZX3 S131P Disease 0.876 0.883 0.03 42 0.887 Q9GZX3 S210F Disease 0.978 0.944 0.00 78 0.963 Q9GZX3 V198E Disease 0.794 0.881 0.00 69 0.915 Q9GZX3 Y110C Disease 0.963 0.909 0.00 50 0.954 Q9GZX3 Y268C Disease 0.983 0.954 0.00 58 0.964 Q9GZX3 Y358D Disease 0.941 0.975 0.01 73 0.953 Q9GZX5 R132C Polymorphism 0.570 0.172 0.60 6 0.184 Q9GZX6 S158G Polymorphism NA 0.094 NA 6 0.088 Q9GZX7 R24W Disease NA 0.987 0.00 67 0.928 Q9GZX7 W80R Disease 0.698 0.978 0.04 60 0.930 Q9GZX7 F151S Disease 0.958 0.987 0.00 52 0.963 Q9GZX7 L106P Disease 0.961 0.993 0.00 54 0.931 Q9GZX7 M139V Disease 0.888 0.974 0.00 72 0.953 Q9GZY8 S7C Polymorphism NA 0.077 NA 29 0.054 Q9GZY8 S7I Polymorphism NA 0.105 NA 37 0.068 Q9GZZ6 E355A Polymorphism 0.332 0.096 0.34 5 0.252 Q9H000 R388Q Polymorphism 0.255 0.180 0.08 52 0.174 Q9H009 V64I Polymorphism NA 0.128 0.25 -10 0.164 Q9H015 I306T Polymorphism 0.069 0.203 0.64 -19 0.109 Q9H019 P58S Polymorphism 0.236 0.085 0.54 2 0.098 Q9H069 R191W Polymorphism 0.217 0.647 0.01 31 0.700 Q9H078 R295T Polymorphism 0.423 0.198 0.38 33 0.224 Q9H093 R341L Polymorphism 0.303 0.206 0.23 28 0.337 Q9H093 T309S Polymorphism 0.080 0.178 1.00 -46 0.073 Q9H094 D444E Polymorphism 0.132 0.137 0.45 -31 0.156 Q9H094 L459V Polymorphism 0.139 0.112 0.72 -43 0.098 Q9H094 R198Q Polymorphism 0.204 0.039 1.00 -12 0.036 Q9H095 A112D Polymorphism NA 0.184 0.03 26 0.350 Q9H0A9 P113L Polymorphism 0.573 0.102 0.00 17 0.245 Q9H0B3 A614V Polymorphism NA 0.038 0.02 -17 0.006 Q9H0B3 M359T Polymorphism NA 0.104 0.00 26 0.053 Q9H0B3 P823R Polymorphism 0.735 0.057 NA 23 0.123 Q9H0B3 P835L Polymorphism 0.200 0.035 NA -26 0.041 Q9H0B3 S285T Polymorphism NA 0.015 NA -32 0.016 Q9H0B8 T322S Polymorphism NA 0.435 0.95 -25 0.213 Q9H0C3 R90H Polymorphism NA 0.144 NA 15 0.134 Q9H0D2 K791E Polymorphism 0.271 0.266 0.00 39 0.248 Q9H0D2 P486S Polymorphism NA 0.074 NA -21 0.023 Q9H0D6 R743M Polymorphism 0.405 0.217 0.11 3 0.389 Q9H0E7 R348G Polymorphism NA 0.561 0.41 55 0.565 Q9H0F5 A206T Polymorphism 0.249 0.045 0.93 -34 0.045 Q9H0F6 P294S Polymorphism 0.563 0.076 0.51 25 0.092 Q9H0F6 P311R Polymorphism 0.276 0.062 0.71 -11 0.073 Q9H0F7 T31M Disease 0.651 0.886 0.00 69 0.906 Q9H0F7 T31R Disease 0.501 0.909 0.00 79 0.910 Q9H0F7 G169A Disease 0.593 0.830 0.07 48 0.856 Q9H0F7 L170W Disease 0.880 0.722 0.00 47 0.875 Q9H0H3 M257L Polymorphism 0.068 0.500 0.36 -45 0.040 Q9H0I3 S6T Polymorphism NA 0.060 0.00 -31 0.115 Q9H0I9 R442Q Polymorphism 0.504 0.897 0.01 68 0.918 Q9H0J4 H906Y Polymorphism NA 0.034 1.00 43 0.072 Q9H0J4 H974R Polymorphism NA 0.069 0.53 54 0.038 Q9H0J4 I630V Polymorphism 0.122 0.368 1.00 24 0.240 Q9H0J9 A620V Polymorphism 0.277 0.687 0.13 13 0.459 Q9H0K1 P828L Polymorphism NA 0.154 0.00 -27 0.119 Q9H0K1 P829S Polymorphism NA 0.170 0.00 8 0.175 Q9H0K1 R809Q Polymorphism NA 0.057 0.06 34 0.041 Q9H0K1 T458I Polymorphism NA 0.133 0.16 -8 0.130 Q9H0K6 I343V Polymorphism 0.262 0.113 0.79 -8 0.136 Q9H0M4 E365K Polymorphism 0.348 0.232 0.03 47 0.255 Q9H0M5 E269G Polymorphism 0.694 0.217 0.04 23 0.548 Q9H0M5 L321V Polymorphism 0.320 0.500 0.03 65 0.695 Q9H0P0 D137V Disease 0.770 0.787 0.01 51 0.903 Q9H0P0 G280R Disease 0.897 0.967 0.00 65 0.935 Q9H0P0 L181P Disease 0.906 0.965 0.01 57 0.945 Q9H0P0 N229S Disease 0.690 0.894 0.00 58 0.904 Q9H0R4 R85Q Polymorphism 0.115 0.485 0.72 -5 0.111 Q9H0R5 R225W Polymorphism 0.952 0.705 0.00 36 0.880 Q9H0R5 V469M Polymorphism 0.352 0.239 0.42 -19 0.243 Q9H0R6 N263S Polymorphism 0.297 0.099 0.03 -19 0.240 Q9H0T7 V19A Polymorphism 0.084 0.154 0.35 12 0.172 Q9H0T7 L191P Polymorphism NA 0.621 0.29 -20 0.393 Q9H0T7 S184G Polymorphism NA 0.168 0.36 8 0.212 Q9H0U3 V311G Disease 0.575 0.392 0.08 3 0.596 Q9H0U9 A74P Polymorphism NA 0.040 0.50 -55 0.041 Q9H0W5 K507N Polymorphism NA 0.193 0.00 23 0.224 Q9H0W7 T170M Polymorphism 0.585 0.107 0.23 15 0.138 Q9H0Y0 S62P Polymorphism NA 0.235 0.02 -5 0.224 Q9H0Y0 T212M Polymorphism NA 0.045 0.00 23 0.061 Q9H0Z9 P212H Polymorphism 0.123 0.098 0.02 33 0.120 Q9H0Z9 V226L Polymorphism NA 0.060 0.09 27 0.046 Q9H106 N55D Polymorphism 0.183 0.328 0.08 -2 0.024 Q9H114 W88R Polymorphism 0.075 0.106 1.00 27 0.067 Q9H115 A61T Polymorphism 0.655 0.888 0.00 50 0.909 Q9H116 D667N Polymorphism NA 0.078 0.49 43 0.094 Q9H116 K318N Polymorphism 0.176 0.169 0.08 23 0.331 Q9H116 N190S Polymorphism NA 0.083 0.55 39 0.095 Q9H161 P102S Polymorphism NA 0.172 0.75 31 0.047 Q9H161 R218Q Disease 0.999 0.902 0.00 74 0.949 Q9H161 R257T Polymorphism 0.992 0.945 0.02 65 0.940 Q9H161 R272P Disease 0.838 0.751 0.15 64 0.913 Q9H171 E88K Polymorphism NA 0.226 0.50 25 0.094 Q9H171 G70R Polymorphism NA 0.135 0.30 25 0.068 Q9H172 P352L Polymorphism 0.229 0.100 0.35 -5 0.203 Q9H173 Q80R Polymorphism 0.241 0.058 0.80 -27 0.055 Q9H1B5 G60R Polymorphism NA 0.084 0.00 25 0.153 Q9H1C3 A37T Polymorphism NA 0.166 0.00 -20 0.139 Q9H1C7 C90S Polymorphism NA 0.446 0.00 34 0.494 Q9H1D0 C157R Polymorphism 0.179 0.641 0.18 25 0.287 Q9H1D0 M681T Polymorphism 0.173 0.102 1.00 -13 0.023 Q9H1D0 R359Q Polymorphism 0.299 0.229 0.29 2 0.283 Q9H1E3 E119G Polymorphism 0.348 0.090 0.04 14 0.199 Q9H1E3 L137P Polymorphism 0.702 0.300 0.15 7 0.423 Q9H1E5 G303R Polymorphism NA 0.014 0.64 1 0.020 Q9H1E5 Y215C Polymorphism NA 0.516 NA 15 0.445 Q9H1H9 F1600S Polymorphism NA 0.579 NA 17 0.690 Q9H1I8 R96C Polymorphism 0.759 0.358 NA 7 0.520 Q9H1I8 D546G Polymorphism 0.737 0.911 NA 44 0.835 Q9H1I8 P423S Polymorphism 0.343 0.091 NA -26 0.088 Q9H1I8 R509Q Polymorphism 0.198 0.056 NA 10 0.085 Q9H1I8 R639L Polymorphism 0.360 0.401 NA 44 0.593 Q9H1K0 L591P Polymorphism 0.058 0.075 0.24 10 0.021 Q9H1M0 F54L Polymorphism 0.156 0.177 1.00 1 0.108 Q9H1M3 T149S Polymorphism NA 0.153 NA 30 0.170 Q9H1P6 I99V Polymorphism NA 0.182 NA 19 0.085 Q9H1R3 A87V Disease NA 0.152 0.40 36 0.172 Q9H1R3 A95E Disease NA 0.230 0.01 43 0.252 Q9H1R3 K324N Polymorphism NA 0.518 0.03 28 0.789 Q9H1X1 V261I Polymorphism 0.116 0.077 1.00 -2 0.069 Q9H1Y3 A167V Polymorphism 0.134 0.186 0.07 -17 0.209 Q9H1Y3 V183I Polymorphism NA 0.230 0.02 25 0.312 Q9H208 A134T Polymorphism 0.324 0.464 0.60 -26 0.311 Q9H208 I240T Polymorphism 0.202 0.470 0.11 3 0.254 Q9H209 L246F Polymorphism 0.630 0.921 0.01 18 0.597 Q9H209 R221H Polymorphism 0.498 0.395 0.54 -2 0.310 Q9H209 R262Q Polymorphism 0.116 0.435 1.00 21 0.280 Q9H211 A135V Polymorphism NA 0.126 0.85 3 0.116 Q9H221 D19H Polymorphism 0.394 0.192 0.11 49 0.293 Q9H221 G574E Disease 0.173 0.960 0.06 64 0.744 Q9H221 G574R Disease 0.224 0.950 0.04 65 0.926 Q9H221 G575R Polymorphism 0.889 0.918 0.00 73 0.930 Q9H221 L501P Disease 0.894 0.889 0.00 29 0.814 Q9H221 L572P Disease 0.894 0.975 0.01 61 0.937 Q9H221 L596R Disease 0.619 0.686 0.09 58 0.882 Q9H221 P231T Disease 0.833 0.794 0.04 53 0.891 Q9H221 R184H Disease 0.576 0.583 0.22 7 0.708 Q9H221 R263Q Disease 0.721 0.790 0.03 19 0.784 Q9H221 R405H Disease 0.837 0.884 0.01 31 0.880 Q9H221 R543S Disease 0.441 0.199 1.00 -2 0.120 Q9H221 V210M Polymorphism 0.464 0.346 0.05 17 0.372 Q9H221 Y641F Polymorphism 0.228 0.491 0.85 -27 0.328 Q9H222 R50C Polymorphism 0.785 0.848 0.09 34 0.866 Q9H222 C600Y Polymorphism 0.712 0.960 1.00 47 0.800 Q9H222 E146Q Disease 0.727 0.794 0.00 51 0.673 Q9H222 I523V Polymorphism 0.111 0.137 0.91 -22 0.112 Q9H222 N437K Disease 0.359 0.360 0.07 9 0.383 Q9H222 Q604E Polymorphism 0.300 0.257 0.78 0 0.245 Q9H222 R389H Disease 0.581 0.475 0.41 7 0.510 Q9H222 R419H Disease 0.581 0.749 0.03 44 0.835 Q9H222 R419P Disease 0.624 0.950 0.04 68 0.946 Q9H222 R550S Disease 0.447 0.452 0.02 15 0.434 Q9H222 T517S Polymorphism 0.278 0.289 0.07 -7 0.200 Q9H227 C354R Polymorphism 0.068 0.224 1.00 -16 0.031 Q9H227 D106N Polymorphism 0.185 0.231 0.50 -34 0.147 Q9H237 G60R Disease NA 0.900 0.02 68 0.906 Q9H237 C385R Disease 0.408 0.884 0.02 56 0.751 Q9H237 G168R Disease 0.734 0.990 0.00 67 0.914 Q9H237 H341L Disease 0.997 0.940 0.00 56 0.969 Q9H237 R365G Disease 0.763 0.917 0.03 43 0.838 Q9H237 R365Q Disease 0.683 0.851 0.06 54 0.888 Q9H237 S136F Disease 0.677 0.695 0.04 64 0.901 Q9H237 V258E Disease 0.826 0.852 0.11 62 0.933 Q9H237 W439R Disease 0.605 0.951 0.00 73 0.938 Q9H244 R256Q Disease 0.969 0.321 0.31 50 0.809 Q9H244 R265W Disease NA 0.500 0.02 27 0.436 Q9H251 A366T Disease NA 0.455 0.39 8 0.178 Q9H251 A484P Disease 0.703 0.428 0.02 50 0.667 Q9H251 D124G Disease 0.634 0.706 0.00 50 0.814 Q9H251 D990N Disease 0.513 0.299 0.75 44 0.488 Q9H251 E247K Disease NA 0.831 0.17 42 0.752 Q9H251 E960K Polymorphism 0.101 0.106 0.18 46 0.206 Q9H251 G490A Polymorphism 0.614 0.449 0.06 38 0.501 Q9H251 H755Y Disease NA 0.172 1.00 46 0.256 Q9H251 L480Q Disease 0.548 0.245 0.09 11 0.532 Q9H251 N452S Disease NA 0.201 0.08 33 0.348 Q9H251 P240L Disease NA 0.254 0.32 26 0.283 Q9H251 R301Q Disease NA 0.678 0.29 22 0.511 Q9H251 R582Q Disease 0.254 0.201 0.53 52 0.252 Q9H251 S496N Polymorphism 0.101 0.283 0.43 -9 0.166 Q9H251 V746I Polymorphism NA 0.234 0.42 40 0.381 Q9H251 A1586P Disease NA 0.321 0.23 40 0.493 Q9H251 D1341N Disease NA 0.355 0.48 38 0.396 Q9H251 D1846N Disease NA 0.336 0.12 46 0.406 Q9H251 D1930N Disease NA 0.220 0.16 38 0.342 Q9H251 D2045N Disease NA 0.282 0.07 -20 0.278 Q9H251 D2148N Disease NA 0.309 0.41 20 0.355 Q9H251 D2202N Disease NA 0.236 0.14 46 0.419 Q9H251 D2376N Polymorphism NA 0.331 0.00 49 0.468 Q9H251 D2376V Disease NA 0.433 0.00 53 0.608 Q9H251 D2954N Polymorphism NA 0.743 0.96 10 0.461 Q9H251 E1595K Disease NA 0.195 0.09 51 0.359 Q9H251 E2588Q Polymorphism NA 0.157 0.58 -1 0.136 Q9H251 F1888S Disease NA 0.349 0.01 41 0.586 Q9H251 G1186D Disease NA 0.325 0.51 58 0.500 Q9H251 G2017S Disease NA 0.383 0.00 49 0.511 Q9H251 G2744S Disease NA 0.841 0.33 38 0.546 Q9H251 G2771S Disease NA 0.500 0.00 14 0.464 Q9H251 I2125M Polymorphism NA 0.315 0.02 -23 0.366 Q9H251 I2669V Polymorphism NA 0.495 0.80 -9 0.139 Q9H251 I2950N Disease NA 0.783 0.00 34 0.835 Q9H251 N1098S Disease NA 0.383 0.00 42 0.470 Q9H251 N2962S Polymorphism NA 0.270 0.76 0 0.245 Q9H251 P1206R Disease NA 0.324 0.00 57 0.653 Q9H251 P1788L Disease NA 0.277 0.05 -4 0.286 Q9H251 P3059T Disease 0.606 0.114 0.00 -13 0.157 Q9H251 Q1496H Disease NA 0.158 0.10 56 0.381 Q9H251 Q1716P Disease NA 0.710 0.24 13 0.451 Q9H251 R1060W Disease 0.900 0.338 0.18 60 0.675 Q9H251 R1349C Polymorphism NA 0.722 0.17 33 0.831 Q9H251 R1507Q Disease NA 0.141 0.37 53 0.292 Q9H251 R1746Q Disease NA 0.515 0.72 1 0.146 Q9H251 R1912W Disease NA 0.224 0.01 56 0.562 Q9H251 R2029W Disease NA 0.556 0.07 49 0.867 Q9H251 R2171C Polymorphism NA 0.389 0.07 40 0.526 Q9H251 R2465W Disease NA 0.147 0.00 43 0.371 Q9H251 R2608H Disease NA 0.238 0.11 12 0.358 Q9H251 R2833G Disease NA 0.325 0.42 34 0.440 Q9H251 R2956C Disease NA 0.718 0.18 47 0.806 Q9H251 R3175H Disease 0.684 0.103 0.00 -14 0.301 Q9H251 R3189W Disease 0.889 0.270 0.00 43 0.504 Q9H251 S1876N Polymorphism NA 0.177 0.14 -6 0.242 Q9H251 S2517G Disease NA 0.169 0.17 26 0.327 Q9H251 S3245F Disease NA 0.141 NA 39 0.135 Q9H251 T1209A Disease NA 0.170 0.79 49 0.266 Q9H251 T1575A Polymorphism NA 0.224 0.49 39 0.215 Q9H251 T1671S Polymorphism NA 0.279 0.74 30 0.349 Q9H251 T1999S Polymorphism NA 0.254 0.66 -3 0.248 Q9H251 T2530I Disease NA 0.231 0.14 2 0.361 Q9H251 V1090I Disease 0.140 0.163 0.31 34 0.275 Q9H251 V1620M Polymorphism NA 0.195 0.03 40 0.389 Q9H251 V1807M Polymorphism NA 0.126 0.18 54 0.364 Q9H251 V1908I Polymorphism NA 0.144 1.00 -9 0.119 Q9H251 V2283I Polymorphism NA 0.224 0.59 39 0.342 Q9H251 V2933E Polymorphism NA 0.413 0.75 -6 0.244 Q9H251 V2968A Disease NA 0.494 0.11 26 0.496 Q9H254 G1331S Polymorphism 0.224 0.662 0.49 16 0.327 Q9H257 S12N Polymorphism 0.078 0.257 0.16 -26 0.037 Q9H267 L30P Disease 0.939 0.954 0.01 60 0.956 Q9H267 F513S Polymorphism 0.250 0.838 0.04 32 0.553 Q9H267 S243F Disease 0.924 0.646 0.01 36 0.828 Q9H270 V770I Polymorphism 0.154 0.102 0.52 -12 0.121 Q9H295 D349G Polymorphism 0.215 0.142 0.34 23 0.105 Q9H2A2 F402S Polymorphism 0.793 0.867 0.00 57 0.921 Q9H2B2 S142N Polymorphism NA 0.095 0.49 -3 0.183 Q9H2B4 Q556R Polymorphism 0.132 0.435 0.50 -17 0.149 Q9H2C0 A51P Disease 0.453 0.919 0.01 35 0.869 Q9H2C0 I86F Disease 0.375 0.649 0.02 24 0.580 Q9H2C0 R15S Disease NA 0.204 0.54 17 0.200 Q9H2C0 S52G Disease 0.361 0.799 0.00 35 0.730 Q9H2C0 S79L Disease 0.493 0.634 0.01 17 0.579 Q9H2C0 V82F Disease 0.458 0.757 0.01 20 0.787 Q9H2C0 Y89C Disease 0.745 0.831 0.00 62 0.915 Q9H2C0 C570Y Disease 0.679 0.934 0.01 64 0.935 Q9H2C0 E486K Disease NA 0.286 0.47 50 0.398 Q9H2C0 G368R Disease 0.617 0.938 0.00 69 0.848 Q9H2C0 G474R Disease 0.617 0.793 0.00 73 0.915 Q9H2C0 I423T Disease 0.396 0.750 0.01 44 0.710 Q9H2C0 L309R Disease 0.582 0.775 0.01 47 0.680 Q9H2C0 P315L Disease 0.555 0.856 0.09 9 0.477 Q9H2C0 R138H Disease 0.417 0.384 0.01 26 0.414 Q9H2C0 R269Q Disease 0.376 0.852 0.02 36 0.585 Q9H2C0 R545C Disease 0.761 0.457 0.00 52 0.556 Q9H2C0 R545H Disease 0.549 0.306 0.01 29 0.454 Q9H2C0 V195F Disease 0.456 0.937 0.00 45 0.788 Q9H2C2 G101E Polymorphism 0.162 0.349 0.25 10 0.187 Q9H2D1 R117H Polymorphism 0.125 0.231 0.27 -5 0.155 Q9H2D6 E1372D Polymorphism NA 0.110 0.26 -13 0.095 Q9H2D6 F1187L Polymorphism NA 0.388 0.52 29 0.182 Q9H2D6 G1019R Disease NA 0.327 0.00 51 0.524 Q9H2D6 W1377R Polymorphism NA 0.084 0.01 0 0.020 Q9H2E6 D567E Polymorphism 0.260 0.573 0.48 15 0.372 Q9H2E6 R559H Polymorphism 0.351 0.290 0.54 -2 0.269 Q9H2F3 G19S Disease 0.781 0.935 0.00 65 0.946 Q9H2F3 E147K Disease 0.908 0.957 0.00 32 0.904 Q9H2F3 T250A Polymorphism NA 0.440 0.74 -16 0.191 Q9H2F9 V249A Polymorphism 0.388 0.131 0.68 22 0.284 Q9H2G2 A658G Polymorphism NA 0.075 0.10 -47 0.038 Q9H2G2 C552Y Polymorphism NA 0.229 0.01 41 0.106 Q9H2G2 T697I Polymorphism NA 0.059 0.06 -12 0.090 Q9H2G9 Q40R Polymorphism 0.134 0.090 NA 20 0.084 Q9H2J7 A400V Polymorphism NA 0.373 0.29 -35 0.240 Q9H2J7 I603M Polymorphism 0.235 0.248 0.21 0 0.283 Q9H2K0 T68I Polymorphism 0.290 0.111 0.04 10 0.129 Q9H2K8 C727Y Polymorphism NA 0.854 0.04 41 0.816 Q9H2L4 V42G Polymorphism NA 0.633 NA 17 0.680 Q9H2L5 H10Y Polymorphism NA 0.041 1.00 -20 0.065 Q9H2M9 G1052C Disease 0.933 0.913 0.00 52 0.950 Q9H2M9 S1092T Polymorphism 0.403 0.250 0.26 47 0.373 Q9H2R5 P134L Polymorphism 0.128 0.363 0.54 9 0.220 Q9H2S5 D268N Polymorphism 0.147 0.639 0.18 19 0.241 Q9H2U9 I205V Polymorphism 0.067 0.096 1.00 -30 0.085 Q9H2U9 L570V Polymorphism 0.318 0.206 0.23 49 0.382 Q9H2U9 N638H Polymorphism 0.353 0.722 0.24 6 0.472 Q9H2U9 V244M Polymorphism 0.889 0.850 0.00 53 0.915 Q9H2V7 A230P Polymorphism 0.752 0.612 0.28 -11 0.631 Q9H2W1 A183S Polymorphism 0.191 0.128 0.72 40 0.239 Q9H2W6 H106Y Polymorphism 0.084 0.040 1.00 -14 0.027 Q9H2X0 P94S Polymorphism NA 0.114 0.58 -3 0.139 Q9H2X0 M630L Polymorphism 0.574 0.062 0.35 -15 0.015 Q9H2X3 D291N Polymorphism NA 0.718 0.34 0 0.426 Q9H2X3 Y205C Polymorphism 0.740 0.633 0.16 48 0.763 Q9H2X3 Y251C Polymorphism 0.740 0.886 0.17 51 0.789 Q9H2X6 R792Q Polymorphism NA 0.293 0.26 17 0.355 Q9H2Y7 M656V Polymorphism NA 0.098 NA -2 0.029 Q9H2Y7 W103R Polymorphism NA 0.248 NA -6 0.105 Q9H2Y7 P1162T Polymorphism NA 0.121 NA 13 0.027 Q9H2Y9 L33F Polymorphism NA 0.065 0.00 -30 0.025 Q9H300 A137G Polymorphism 0.667 0.258 0.18 -10 0.441 Q9H300 V262L Polymorphism 0.550 0.307 0.50 -46 0.488 Q9H306 R22W Polymorphism NA 0.460 0.02 -57 0.517 Q9H306 I477V Polymorphism 0.077 0.134 NA -51 0.062 Q9H306 W304L Polymorphism 0.670 0.907 0.05 56 0.794 Q9H307 S441T Polymorphism 0.290 0.053 0.43 -81 0.205 Q9H310 G315R Polymorphism 0.368 0.944 0.00 58 0.921 Q9H310 V143D Polymorphism 0.494 0.939 0.00 52 0.896 Q9H322 A70G Polymorphism 0.096 0.038 1.00 -51 0.007 Q9H324 A25T Disease NA 0.131 0.70 -10 0.189 Q9H324 R119Q Polymorphism NA 0.247 0.59 -36 0.229 Q9H330 D9E Polymorphism NA 0.026 1.00 -22 0.018 Q9H330 A314T Polymorphism NA 0.075 0.17 -35 0.045 Q9H330 T787A Polymorphism 0.598 0.307 0.00 -6 0.583 Q9H339 I102T Polymorphism 0.539 0.755 0.01 24 0.853 Q9H339 L220F Polymorphism 0.557 0.868 0.07 1 0.512 Q9H340 K5T Polymorphism NA 0.263 0.86 5 0.164 Q9H340 I90T Polymorphism 0.325 0.835 0.11 60 0.851 Q9H340 F192L Polymorphism 0.196 0.464 0.57 24 0.295 Q9H340 L172F Polymorphism 0.322 0.802 0.14 42 0.737 Q9H340 T123A Polymorphism 0.989 0.061 1.00 -11 0.047 Q9H344 T134A Polymorphism 0.270 0.320 0.42 13 0.353 Q9H346 R154C Polymorphism 0.941 0.931 0.19 40 0.910 Q9H347 T290S Polymorphism 0.241 0.055 0.83 -20 0.043 Q9H3D4 C308Y Disease 0.981 0.974 0.00 68 0.969 Q9H3D4 C345R Disease 0.972 0.957 0.00 74 0.969 Q9H3D4 C347S Disease 0.929 0.956 0.00 58 0.953 Q9H3D4 C561G Disease 0.660 0.461 0.00 45 0.576 Q9H3D4 D351G Disease 0.916 0.946 0.00 62 0.949 Q9H3D4 D351H Disease 0.963 0.885 0.00 66 0.937 Q9H3D4 D603H Polymorphism 0.361 0.227 0.00 31 0.383 Q9H3D4 I549T Disease 0.377 0.168 0.01 37 0.211 Q9H3D4 K232E Disease 0.884 0.833 0.00 19 0.813 Q9H3D4 K233E Disease 0.652 0.828 0.00 48 0.833 Q9H3D4 L553F Disease 0.354 0.259 0.00 51 0.430 Q9H3D4 P348S Disease 0.944 0.832 0.00 58 0.935 Q9H3D4 R243Q Disease 0.926 0.942 0.00 63 0.948 Q9H3D4 R243W Disease 0.987 0.963 0.00 66 0.966 Q9H3D4 R266Q Disease 0.923 0.936 0.00 64 0.966 Q9H3D4 R318C Disease 0.981 0.978 0.00 67 0.966 Q9H3D4 R318H Disease 0.958 0.947 0.00 68 0.964 Q9H3D4 R318Q Disease 0.923 0.957 0.00 59 0.946 Q9H3D4 R319C Disease 0.977 0.978 0.00 58 0.965 Q9H3D4 R319H Disease 0.947 0.951 0.00 65 0.953 Q9H3D4 R319S Disease 0.926 0.962 0.00 52 0.939 Q9H3D4 R337Q Disease 0.901 0.923 0.00 58 0.836 Q9H3D4 R343Q Disease 0.901 0.916 0.00 62 0.944 Q9H3D4 R343W Disease 0.983 0.964 0.00 66 0.965 Q9H3D4 R352G Disease 0.922 0.935 0.00 42 0.906 Q9H3D4 S129L Polymorphism NA 0.194 0.16 3 0.324 Q9H3D4 S311N Disease 0.912 0.900 0.00 70 0.943 Q9H3D4 S580P Disease 0.321 0.294 0.01 41 0.424 Q9H3E2 I586V Polymorphism 0.108 0.083 0.41 31 0.095 Q9H3E2 T725I Polymorphism 0.267 0.170 0.09 19 0.181 Q9H3G5 A435V Polymorphism 0.232 0.474 0.50 -1 0.252 Q9H3H5 I393V Polymorphism 0.204 0.087 0.67 -24 0.121 Q9H3H5 Y170C Disease 0.883 0.904 0.12 31 0.889 Q9H3L0 L259P Disease 0.717 0.923 NA 24 0.848 Q9H3L0 T182N Disease 0.087 0.441 NA 37 0.203 Q9H3L0 Y249C Disease 0.843 0.680 NA 47 0.839 Q9H3M7 R177Q Polymorphism 0.116 0.233 0.57 8 0.135 Q9H3M9 L266F Polymorphism 0.310 0.058 0.15 15 0.109 Q9H3N8 H206R Polymorphism 0.193 0.427 0.81 10 0.184 Q9H3P2 S335A Polymorphism 0.190 0.142 0.55 -30 0.057 Q9H3P7 E187D Polymorphism 0.295 0.107 0.03 -13 0.136 Q9H3R0 E206D Polymorphism 0.380 0.671 0.24 -1 0.486 Q9H3R0 N697S Polymorphism 0.138 0.427 0.48 16 0.232 Q9H3R0 Q767E Polymorphism 0.174 0.650 1.00 40 0.437 Q9H3R0 V1039I Polymorphism 0.190 0.140 0.16 -30 0.045 Q9H3S1 D345H Disease 0.613 0.837 0.01 28 0.860 Q9H3S1 F350C Disease 0.980 0.909 0.00 23 0.946 Q9H3S1 R510Q Polymorphism 0.934 0.869 0.14 37 0.891 Q9H3S1 R713Q Disease 0.400 0.161 0.44 42 0.133 Q9H3S3 R46Q Polymorphism NA 0.068 0.58 10 0.034 Q9H3S3 F369L Polymorphism 0.142 0.071 0.13 -15 0.153 Q9H3S5 F365L Polymorphism 0.132 0.158 0.38 -53 0.117 Q9H3S7 A944T Polymorphism NA 0.068 0.83 26 0.027 Q9H3U1 T796M Polymorphism NA 0.321 0.00 33 0.438 Q9H3U5 I271T Polymorphism 0.474 0.375 0.03 17 0.457 Q9H3U5 K168E Polymorphism 0.246 0.900 0.00 45 0.625 Q9H3Y6 G75R Polymorphism 0.772 0.852 0.02 48 0.888 Q9H3Y6 I88V Polymorphism 0.133 0.159 0.03 1 0.163 Q9H3Y6 R73C Polymorphism 0.493 0.257 0.01 49 0.435 Q9H3Y6 A397V Polymorphism 0.516 0.745 0.05 -17 0.411 Q9H3Y6 A453T Polymorphism 0.321 0.084 0.42 -27 0.219 Q9H3Y6 D377E Polymorphism 0.256 0.450 0.37 -14 0.290 Q9H3Y6 P218L Polymorphism NA 0.275 0.31 -9 0.289 Q9H3Y6 P325L Polymorphism 0.575 0.293 0.28 -7 0.519 Q9H3Y6 P452L Polymorphism 0.734 0.808 0.08 42 0.763 Q9H3Y6 S465T Polymorphism 0.184 0.079 0.54 -57 0.134 Q9H3Y6 V255M Polymorphism 0.586 0.934 0.00 49 0.869 Q9H3Y6 V301L Polymorphism 0.208 0.723 0.10 38 0.349 Q9H3Y6 V457L Polymorphism 0.208 0.157 0.21 -29 0.167 Q9H422 C191R Polymorphism 0.627 0.771 0.02 52 0.843 Q9H422 P729L Polymorphism NA 0.259 0.05 23 0.351 Q9H422 V474I Polymorphism NA 0.086 0.34 -47 0.157 Q9H427 G95E Polymorphism 0.999 0.926 0.00 69 0.959 Q9H444 D129V Disease 0.886 0.830 0.00 27 0.882 Q9H444 E161K Disease 0.718 0.694 0.01 44 0.846 Q9H488 D348N Polymorphism 0.161 0.500 0.92 22 0.314 Q9H489 P246H Polymorphism 0.972 0.702 0.00 48 0.916 Q9H497 F13L Polymorphism 0.109 0.125 NA -46 0.030 Q9H4A3 A141T Polymorphism NA 0.333 0.03 29 0.488 Q9H4A3 A149V Polymorphism NA 0.235 0.59 21 0.205 Q9H4A3 D527G Polymorphism 0.555 0.913 0.06 56 0.908 Q9H4A3 I509T Polymorphism 0.416 0.317 0.40 50 0.367 Q9H4A3 T674A Polymorphism 0.304 0.129 0.02 41 0.299 Q9H4A3 P1823L Polymorphism 0.100 0.118 0.00 3 0.147 Q9H4A3 R1957H Polymorphism 0.553 0.609 0.05 38 0.766 Q9H4B4 S498L Polymorphism 0.206 0.139 0.69 -7 0.112 Q9H4B7 Q43P Polymorphism NA 0.839 0.11 23 0.611 Q9H4B7 R307H Polymorphism 0.144 0.177 1.00 -21 0.110 Q9H4D5 N186I Polymorphism 0.540 0.579 0.18 45 0.724 Q9H4E7 N287T Polymorphism 0.135 0.138 0.26 7 0.066 Q9H4E7 R578H Polymorphism 0.534 0.432 0.00 42 0.530 Q9H4G1 H109P Polymorphism 0.247 0.063 0.61 -6 0.025 Q9H4I8 E3K Polymorphism NA 0.078 0.00 -28 0.109 Q9H4I8 S46N Polymorphism 0.497 0.333 0.54 -32 0.180 Q9H4I8 C306R Polymorphism 0.758 0.109 0.17 2 0.081 Q9H4K1 F195L Polymorphism 0.077 0.104 0.69 -13 0.075 Q9H4K1 R180C Polymorphism 0.651 0.141 0.05 3 0.414 Q9H4K1 R262Q Polymorphism 0.068 0.029 0.04 -17 0.036 Q9H4K7 H93R Polymorphism 0.457 0.262 1.00 18 0.273 Q9H4L7 L135F Polymorphism NA 0.092 NA 36 0.070 Q9H4L7 P351Q Polymorphism NA 0.208 0.03 29 0.183 Q9H4L7 S245Y Polymorphism NA 0.060 0.00 35 0.153 Q9H4L7 S247N Polymorphism NA 0.046 0.01 7 0.069 Q9H4L7 V972A Polymorphism 0.989 0.848 0.01 45 0.904 Q9H4M7 T714A Polymorphism 0.224 0.073 0.15 8 0.055 Q9H4Y5 N142D Polymorphism 0.339 0.161 0.95 -37 0.116 Q9H501 I824L Polymorphism 0.190 0.045 0.78 7 0.074 Q9H503 T78S Polymorphism 0.066 0.091 0.27 29 0.044 Q9H511 V156I Polymorphism 0.169 0.057 0.54 25 0.116 Q9H568 R245C Polymorphism 0.760 0.609 0.03 8 0.688 Q9H582 A794V Polymorphism NA 0.074 NA 42 0.061 Q9H582 M556V Polymorphism NA 0.049 0.02 -19 0.037 Q9H583 D957G Polymorphism 0.376 0.166 0.13 25 0.164 Q9H583 H348R Polymorphism 0.106 0.043 0.67 -4 0.031 Q9H583 M607V Polymorphism 0.135 0.198 0.13 15 0.283 Q9H583 E2017G Polymorphism 0.282 0.140 0.38 37 0.240 Q9H583 N1694S Polymorphism 0.268 0.072 0.83 6 0.080 Q9H583 N1967D Polymorphism 0.178 0.178 0.35 18 0.128 Q9H583 R1654H Polymorphism 0.522 0.103 0.22 22 0.118 Q9H583 S1559N Polymorphism 0.321 0.025 0.37 -33 0.070 Q9H583 V1854A Polymorphism 0.195 0.052 0.76 22 0.084 Q9H583 Y1433C Polymorphism 0.529 0.201 0.16 34 0.267 Q9H598 S423G Polymorphism NA 0.293 0.54 -22 0.248 Q9H5F2 Q85H Polymorphism NA 0.151 0.04 20 0.161 Q9H5F2 V40A Polymorphism NA 0.282 0.00 50 0.434 Q9H5H4 E181D Polymorphism NA 0.122 0.62 39 0.202 Q9H5K3 M301T Polymorphism 0.284 0.141 0.04 6 0.167 Q9H5K3 V254M Polymorphism 0.572 0.303 0.00 50 0.575 Q9H5K3 Y140F Polymorphism 0.226 0.249 0.11 34 0.213 Q9H5L6 L299F Polymorphism NA 0.076 NA 6 0.104 Q9H5L6 M284I Polymorphism NA 0.594 0.00 -13 0.463 Q9H5L6 N812D Polymorphism 0.272 0.072 NA 12 0.028 Q9H5Q4 P156L Polymorphism NA 0.570 0.22 33 0.704 Q9H5Z1 I189T Polymorphism 0.857 0.259 0.01 18 0.519 Q9H5Z1 P703L Polymorphism NA 0.393 0.00 -13 0.412 Q9H5Z6 I257T Polymorphism NA 0.080 0.69 -37 0.025 Q9H607 A109G Polymorphism NA 0.058 0.46 -10 0.045 Q9H611 I640N Polymorphism 0.153 0.075 0.41 -20 0.013 Q9H628 M163V Polymorphism NA 0.136 0.28 -17 0.157 Q9H633 Q149K Polymorphism 0.117 0.050 0.00 35 0.106 Q9H649 A295V Polymorphism 0.064 0.549 0.55 18 0.143 Q9H668 S248C Polymorphism NA 0.068 0.11 -7 0.052 Q9H668 T151A Polymorphism NA 0.181 0.49 17 0.124 Q9H694 G8D Polymorphism 0.247 0.247 0.00 36 0.240 Q9H694 N945S Polymorphism NA 0.304 0.00 -1 0.457 Q9H6A9 K813N Polymorphism 0.224 0.216 0.04 33 0.319 Q9H6A9 Q258R Polymorphism NA 0.032 0.72 31 0.015 Q9H6B4 R69H Polymorphism 0.498 0.290 0.15 26 0.384 Q9H6F5 Q153H Polymorphism 0.069 0.138 0.13 37 0.080 Q9H6K4 G93S Disease 0.571 0.807 0.10 9 0.786 Q9H6K4 Q105E Disease 0.160 0.131 0.95 -11 0.183 Q9H6L5 Q379E Polymorphism NA 0.056 0.64 -22 0.066 Q9H6Q3 V210M Polymorphism 0.470 0.099 0.23 -21 0.093 Q9H6Q4 V38M Polymorphism NA 0.130 0.14 16 0.244 Q9H6Q4 H444R Polymorphism 0.175 0.151 0.48 0 0.130 Q9H6R0 R118C Polymorphism 0.954 0.658 0.05 43 0.794 Q9H6R7 T102M Polymorphism NA 0.045 0.09 -8 0.015 Q9H6T0 P627S Polymorphism 0.186 0.245 0.07 -4 0.327 Q9H6T0 S111L Polymorphism NA 0.066 0.08 -13 0.072 Q9H6U8 A232P Polymorphism 0.955 0.887 0.05 36 0.926 Q9H6U8 E523K Disease 0.482 0.485 0.04 51 0.682 Q9H6U8 S255L Polymorphism 0.368 0.466 0.69 -24 0.416 Q9H6U8 V289I Polymorphism 0.520 0.559 0.16 -1 0.444 Q9H6U8 Y287C Disease 0.991 0.977 0.00 60 0.968 Q9H6W3 F218S Polymorphism 0.803 0.979 0.00 44 0.896 Q9H6Y5 F323L Polymorphism 0.446 0.074 1.00 -22 0.025 Q9H6Z9 S234T Polymorphism 0.183 0.035 0.00 1 0.055 Q9H706 A490V Polymorphism 0.282 0.090 0.15 -2 0.087 Q9H706 T243N Polymorphism 0.544 0.500 0.00 10 0.511 Q9H707 W242C Polymorphism 0.922 0.467 1.00 9 0.144 Q9H714 G152R Polymorphism 0.465 0.092 0.00 26 0.044 Q9H741 Q55R Polymorphism 0.215 0.103 0.15 0 0.096 Q9H777 M355V Polymorphism 0.081 0.392 0.50 23 0.416 Q9H788 S275N Polymorphism 0.418 0.109 0.52 -36 0.209 Q9H790 G172V Polymorphism NA 0.190 0.62 23 0.054 Q9H792 S792I Polymorphism NA 0.121 NA 19 0.112 Q9H792 R1071K Polymorphism 0.148 0.086 NA 19 0.054 Q9H792 R1699G Polymorphism 0.857 0.539 NA 44 0.819 Q9H792 S1542T Polymorphism 0.255 0.096 NA 32 0.095 Q9H792 T1077P Polymorphism 0.529 0.146 NA 5 0.160 Q9H799 I1023V Polymorphism NA 0.044 NA -21 0.020 Q9H7B2 G60S Polymorphism 0.144 0.172 0.77 -39 0.099 Q9H7C9 V92M Polymorphism NA 0.215 0.00 48 0.383 Q9H7D0 Q250R Polymorphism 0.011 0.241 0.08 -10 0.103 Q9H7D0 E1836K Polymorphism 0.030 0.078 0.26 1 0.048 Q9H7D0 K1285R Polymorphism 0.122 0.118 0.54 -26 0.099 Q9H7D0 Q1023R Polymorphism 0.111 0.357 0.82 -9 0.291 Q9H7H0 A346P Polymorphism 0.275 0.628 0.14 -3 0.391 Q9H7N4 T895A Polymorphism 0.399 0.076 0.27 11 0.037 Q9H7P9 I622V Polymorphism NA 0.055 0.25 19 0.037 Q9H7P9 R647H Polymorphism NA 0.092 0.14 29 0.031 Q9H7P9 T540I Polymorphism NA 0.097 0.16 24 0.072 Q9H7R0 I93V Polymorphism NA 0.068 1.00 -27 0.038 Q9H7R0 G422R Polymorphism 0.093 0.346 0.64 1 0.037 Q9H7R0 P110T Polymorphism NA 0.083 0.42 8 0.187 Q9H7T9 K82T Polymorphism NA 0.035 0.04 35 0.091 Q9H7U1 C755Y Polymorphism NA 0.233 0.14 31 0.151 Q9H7U1 P821S Polymorphism NA 0.183 0.00 40 0.330 Q9H7U1 S819P Polymorphism NA 0.023 0.85 -43 0.004 Q9H7V2 G54R Polymorphism 0.379 0.123 0.14 60 0.130 Q9H7Y0 R128K Polymorphism NA 0.060 0.37 -12 0.077 Q9H7Y0 R146Q Polymorphism NA 0.164 0.46 7 0.151 Q9H7Z3 C32F Polymorphism 0.242 0.173 0.16 21 0.152 Q9H7Z7 R298H Polymorphism 0.133 0.068 0.40 -38 0.055 Q9H814 R82C Polymorphism 0.781 0.411 0.00 51 0.644 Q9H816 H61Y Polymorphism 0.452 0.193 0.72 -8 0.191 Q9H816 R46L Polymorphism 0.575 0.600 0.68 35 0.479 Q9H816 D462N Polymorphism 0.310 0.107 NA 19 0.052 Q9H867 A63D Polymorphism 0.361 0.478 0.29 20 0.587 Q9H875 S7A Polymorphism 0.113 0.019 0.82 -21 0.024 Q9H875 D106Y Polymorphism 0.494 0.484 0.00 15 0.617 Q9H892 M468L Polymorphism 0.158 0.070 0.02 13 0.131 Q9H8E8 A738S Polymorphism 0.377 0.639 NA -1 0.610 Q9H8E8 P600R Polymorphism 0.746 0.726 NA 59 0.915 Q9H8G2 V233M Polymorphism NA 0.033 NA 16 0.056 Q9H8H0 V115A Polymorphism 0.232 0.121 0.47 6 0.090 Q9H8H2 I799V Polymorphism NA 0.053 0.55 7 0.032 Q9H8H2 R687Q Polymorphism NA 0.208 0.49 -12 0.215 Q9H8J5 V55I Polymorphism 0.118 0.022 NA -13 0.027 Q9H8J5 D165N Polymorphism 0.200 0.113 NA 15 0.043 Q9H8J5 N375Y Polymorphism 0.420 0.064 NA 30 0.067 Q9H8L6 S831R Polymorphism 0.501 0.360 0.02 35 0.563 Q9H8M1 L48F Polymorphism 0.343 0.060 0.21 16 0.085 Q9H8M9 R150H Polymorphism NA 0.309 0.29 18 0.247 Q9H8V3 S15T Polymorphism NA 0.098 0.00 4 0.159 Q9H8W5 C375Y Polymorphism 0.412 0.565 1.00 28 0.736 Q9H8W5 M496T Polymorphism 0.102 0.119 0.74 -11 0.086 Q9H8W5 R353Q Polymorphism 0.416 0.723 0.18 52 0.642 Q9H8W5 R413Q Polymorphism 0.416 0.273 0.37 63 0.465 Q9H8X2 R277W Polymorphism 0.830 0.312 0.06 48 0.497 Q9H8X3 S27C Polymorphism NA 0.100 NA 36 0.058 Q9H8X3 K119R Polymorphism NA 0.109 NA 16 0.060 Q9H8X9 R341Q Polymorphism NA 0.061 0.12 32 0.022 Q9H8X9 R372H Polymorphism NA 0.241 NA 25 0.064 Q9H8Y1 L53F Polymorphism NA 0.066 0.20 16 0.036 Q9H8Y5 P676L Polymorphism NA 0.135 0.01 -7 0.165 Q9H8Y5 R569W Polymorphism NA 0.352 0.07 26 0.503 Q9H8Y8 S432F Polymorphism 0.089 0.115 0.71 -6 0.067 Q9H900 S344G Polymorphism NA 0.022 1.00 -45 0.016 Q9H902 A20E Disease 0.878 0.942 0.00 47 0.905 Q9H930 T225M Polymorphism NA 0.088 0.24 -22 0.066 Q9H936 P206L Disease 0.859 0.277 0.68 8 0.605 Q9H939 N322D Polymorphism 0.210 0.025 0.66 -20 0.049 Q9H939 N322S Polymorphism 0.146 0.039 1.00 0 0.052 Q9H967 S614G Polymorphism NA 0.843 0.05 49 0.681 Q9H972 A190V Polymorphism NA 0.054 NA 26 0.060 Q9H981 T56I Polymorphism NA 0.257 0.11 7 0.364 Q9H987 S833Y Polymorphism NA 0.238 0.22 39 0.266 Q9H992 T100S Polymorphism 0.154 0.075 0.37 -20 0.028 Q9H993 K73N Polymorphism 0.582 0.461 0.18 -30 0.541 Q9H993 A317T Polymorphism 0.287 0.168 0.67 -49 0.160 Q9H993 G150E Polymorphism 0.215 0.067 0.88 -4 0.039 Q9H9A5 T348S Polymorphism 0.288 0.467 0.08 -11 0.330 Q9H9A6 I500V Polymorphism 0.188 0.330 0.06 -21 0.146 Q9H9A7 Y100H Polymorphism 0.266 0.610 0.00 57 0.609 Q9H9B4 N26S Polymorphism 0.145 0.197 0.27 -16 0.164 Q9H9B4 P266S Polymorphism 0.883 0.788 0.06 35 0.856 Q9H9D4 R337P Polymorphism NA 0.819 0.11 44 0.835 Q9H9F9 I461L Polymorphism 0.258 0.782 0.57 -8 0.408 Q9H9J2 T138I Polymorphism NA 0.129 0.01 20 0.265 Q9H9J4 L1030P Polymorphism NA 0.192 NA 16 0.095 Q9H9P8 G55D Disease 0.997 0.939 0.00 77 0.961 Q9H9P8 G57R Disease 0.998 0.967 0.00 79 0.960 Q9H9P8 H98R Disease 0.941 0.901 0.00 74 0.937 Q9H9P8 H98Y Disease 0.928 0.895 0.00 72 0.931 Q9H9P8 K81E Disease 0.529 0.752 0.00 21 0.628 Q9H9P8 R33S Polymorphism NA 0.305 0.54 32 0.243 Q9H9P8 E176D Disease 0.424 0.810 0.00 39 0.760 Q9H9P8 H434P Disease 0.887 0.932 0.22 60 0.945 Q9H9P8 P302L Disease 0.939 0.810 0.36 45 0.911 Q9H9Q4 R57G Disease NA 0.543 0.00 54 0.730 Q9H9Q4 C123R Disease NA 0.916 0.00 64 0.929 Q9H9Q4 Q256L Polymorphism NA 0.086 0.05 -7 0.083 Q9H9S5 R54W Disease 0.729 0.658 NA 61 0.841 Q9H9S5 A114G Disease 0.344 0.134 NA 13 0.120 Q9H9S5 A455D Disease 0.297 0.345 0.02 53 0.604 Q9H9S5 C318Y Disease 0.241 0.834 NA 39 0.677 Q9H9S5 D360N Disease 0.538 0.667 0.08 39 0.740 Q9H9S5 D401N Disease 0.259 0.146 0.00 7 0.161 Q9H9S5 L276I Disease 0.230 0.156 NA 15 0.134 Q9H9S5 P217T Disease 0.250 0.500 NA 34 0.650 Q9H9S5 P315T Disease 0.297 0.564 NA 21 0.655 Q9H9S5 P316R Disease 0.081 0.586 NA 7 0.625 Q9H9S5 P316S Disease 0.257 0.534 NA 11 0.639 Q9H9S5 P448L Disease 0.151 0.683 0.02 47 0.655 Q9H9S5 P462S Disease 0.231 0.682 0.00 50 0.793 Q9H9S5 R143S Disease 0.471 0.259 NA 27 0.388 Q9H9S5 R312C Disease 0.720 0.458 NA 37 0.641 Q9H9S5 R339H Disease 0.501 0.614 0.05 23 0.698 Q9H9S5 R339L Disease 0.417 0.833 0.06 30 0.749 Q9H9S5 S221R Disease 0.514 0.203 NA 41 0.356 Q9H9S5 V405L Disease 0.207 0.500 0.19 18 0.595 Q9H9S5 Y307N Disease 0.291 0.883 NA 43 0.683 Q9H9S5 Y309C Disease 0.661 0.884 NA 57 0.907 Q9H9S5 Y328S Disease 0.303 0.678 0.06 -2 0.554 Q9H9S5 Y465S Disease 0.283 0.325 0.08 13 0.409 Q9H9V9 A11V Polymorphism NA 0.021 NA 13 0.029 Q9H9V9 D65E Polymorphism NA 0.062 0.49 6 0.056 Q9H9V9 A461V Polymorphism 0.116 0.033 0.12 -4 0.041 Q9H9Y2 S9G Polymorphism NA 0.074 0.41 -7 0.025 Q9H9Y2 M223I Polymorphism 0.359 0.281 0.43 9 0.203 Q9H9Y4 Q227R Polymorphism 0.158 0.437 0.20 -9 0.154 Q9H9Y6 S295L Polymorphism NA 0.268 0.52 3 0.214 Q9HA72 V136G Polymorphism NA 0.655 0.10 22 0.515 Q9HA72 V194M Polymorphism NA 0.118 0.13 16 0.208 Q9HA82 A366T Polymorphism 0.148 0.056 0.41 9 0.096 Q9HA82 G301S Polymorphism 0.315 0.694 0.51 -7 0.422 Q9HA92 L126S Polymorphism 0.371 0.277 0.38 12 0.379 Q9HAC7 R336W Disease 0.314 0.454 0.19 -12 0.259 Q9HAD4 G61D Polymorphism 0.606 0.667 0.06 46 0.799 Q9HAH1 R137C Polymorphism 0.801 0.812 0.03 41 0.893 Q9HAH1 R146L Polymorphism 0.440 0.597 0.14 -9 0.140 Q9HAS3 R4K Polymorphism NA 0.142 0.00 28 0.049 Q9HAS3 S5N Polymorphism NA 0.080 0.40 16 0.021 Q9HAS3 I328V Polymorphism 0.131 0.212 0.75 -46 0.130 Q9HAS3 L131F Polymorphism 0.709 0.483 0.00 -18 0.564 Q9HAS3 L418I Polymorphism 0.236 0.121 0.48 -18 0.147 Q9HAS3 R349Q Polymorphism 0.075 0.696 0.15 38 0.178 Q9HAS3 Y513F Polymorphism 0.236 0.500 0.54 -27 0.405 Q9HAT1 R105Q Polymorphism 0.434 0.120 0.53 13 0.233 Q9HAT1 R517S Polymorphism 0.239 0.151 NA 57 0.232 Q9HAT2 K71R Polymorphism 0.233 0.188 0.00 0 0.288 Q9HAV4 K610N Polymorphism NA 0.371 0.14 -20 0.377 Q9HAV4 S241N Polymorphism NA 0.136 0.49 -16 0.101 Q9HAW4 P892T Polymorphism 0.237 0.066 0.56 18 0.086 Q9HAW7 W208R Polymorphism 0.577 0.451 0.23 12 0.488 Q9HAW8 M59I Polymorphism 0.635 0.459 0.47 -17 0.429 Q9HAW8 L244I Polymorphism NA 0.756 0.33 -35 0.528 Q9HAW8 T202I Polymorphism 0.959 0.865 0.03 6 0.880 Q9HAW9 H53N Polymorphism 0.944 0.798 0.00 34 0.849 Q9HAW9 A144V Polymorphism 0.684 0.709 1.00 -44 0.557 Q9HAW9 G154A Polymorphism 0.808 0.862 0.04 9 0.818 Q9HAW9 K132R Polymorphism 0.661 0.421 0.26 -21 0.561 Q9HAW9 M212L Polymorphism 0.610 0.690 0.60 -20 0.447 Q9HAW9 T202A Polymorphism 0.895 0.745 0.01 30 0.844 Q9HAY2 K93R Polymorphism 0.089 0.288 0.28 -18 0.221 Q9HAY6 R267S Polymorphism 0.185 0.249 0.05 32 0.190 Q9HAZ1 I363V Polymorphism 0.171 0.025 0.20 -1 0.160 Q9HAZ1 L352F Polymorphism 0.792 0.631 0.25 44 0.820 Q9HAZ2 S533P Polymorphism NA 0.226 0.34 48 0.209 Q9HB14 G305R Polymorphism 0.688 0.201 0.02 0 0.215 Q9HB14 G389A Polymorphism 0.511 0.227 0.00 28 0.418 Q9HB21 T320A Polymorphism 0.098 0.068 0.56 -33 0.015 Q9HB29 L550P Polymorphism 0.850 0.582 0.00 35 0.713 Q9HB29 V352I Polymorphism 0.078 0.175 0.77 -21 0.081 Q9HB40 L3V Polymorphism NA 0.096 0.00 -57 0.086 Q9HB55 M145I Polymorphism 0.231 0.896 0.01 29 0.560 Q9HB55 M275I Polymorphism 0.571 0.681 0.05 17 0.561 Q9HB55 P340A Polymorphism 0.774 0.089 0.06 -47 0.302 Q9HB58 A128V Polymorphism 0.329 0.111 0.14 25 0.128 Q9HB58 A206V Polymorphism 0.334 0.057 0.43 3 0.032 Q9HB58 E212G Polymorphism 0.503 0.162 0.29 25 0.138 Q9HB58 E267G Polymorphism 0.504 0.183 0.07 30 0.238 Q9HB58 L425S Polymorphism 0.433 0.087 0.02 -21 0.087 Q9HB58 M249V Polymorphism 0.230 0.068 0.18 24 0.073 Q9HB58 M523T Polymorphism 0.197 0.099 0.36 34 0.142 Q9HB58 M579I Polymorphism 0.166 0.094 0.18 4 0.154 Q9HB58 S173L Polymorphism 0.527 0.077 0.33 -34 0.088 Q9HB58 S210A Polymorphism 0.196 0.127 0.93 12 0.101 Q9HB65 Q11E Polymorphism 0.215 0.079 NA 21 0.058 Q9HB65 W140R Polymorphism 0.444 0.436 0.09 46 0.185 Q9HB96 R89L Polymorphism NA 0.156 NA -6 0.032 Q9HB96 A502T Polymorphism NA 0.057 NA 18 0.069 Q9HB96 G340R Polymorphism NA 0.483 NA 49 0.543 Q9HB96 R343Q Polymorphism NA 0.038 NA -5 0.032 Q9HBA0 P19S Polymorphism NA 0.145 0.42 -30 0.146 Q9HBA0 R616Q Disease 0.396 0.579 0.02 46 0.749 Q9HBA0 V620I Disease 0.492 0.127 0.12 19 0.179 Q9HBE5 G484S Polymorphism 0.166 0.079 0.00 -5 0.149 Q9HBE5 R191C Polymorphism 0.644 0.075 0.05 39 0.079 Q9HBE5 S318R Polymorphism 0.459 0.294 0.03 36 0.442 Q9HBG4 G175D Disease NA 0.971 0.00 46 0.877 Q9HBG4 G820R Disease 0.967 0.959 0.01 57 0.951 Q9HBG4 M580T Disease 0.391 0.630 0.01 16 0.592 Q9HBG4 P524L Disease 0.967 0.956 0.32 36 0.922 Q9HBG4 R449H Disease 0.975 0.921 0.00 69 0.958 Q9HBG4 R807Q Disease 0.967 0.955 0.00 62 0.958 Q9HBG7 M602V Polymorphism NA 0.035 NA -32 0.019 Q9HBH1 W11R Polymorphism NA 0.226 NA 49 0.059 Q9HBH7 V9L Polymorphism NA 0.093 0.34 22 0.074 Q9HBH7 S13I Polymorphism NA 0.051 0.03 28 0.073 Q9HBH9 Q10K Polymorphism NA 0.264 1.00 1 0.098 Q9HBH9 R428Q Polymorphism NA 0.081 0.34 45 0.086 Q9HBI1 P52R Polymorphism 0.588 0.588 0.03 45 0.600 Q9HBI6 R146C Polymorphism 0.543 0.691 0.06 30 0.794 Q9HBJ7 E586K Polymorphism NA 0.062 0.72 38 0.067 Q9HBJ7 N368S Polymorphism 0.143 0.121 0.65 36 0.139 Q9HBK9 M287T Polymorphism 0.160 0.094 0.00 -18 0.188 Q9HBK9 T306I Polymorphism 0.398 0.735 0.00 21 0.616 Q9HBL0 R466C Polymorphism NA 0.293 0.02 45 0.374 Q9HBL0 W1197R Polymorphism NA 0.086 0.65 15 0.042 Q9HBL6 E43K Polymorphism 0.258 0.188 0.74 -3 0.181 Q9HBL6 L117V Polymorphism 0.238 0.373 0.27 -35 0.164 Q9HBL8 P252L Polymorphism 0.451 0.823 0.05 -8 0.543 Q9HBQ8 A110V Polymorphism 0.188 0.076 0.02 28 0.167 Q9HBT6 P328H Polymorphism 0.384 0.450 0.23 38 0.543 Q9HBT6 P391L Polymorphism 0.337 0.236 0.31 13 0.331 Q9HBT6 Q371R Polymorphism 0.082 0.320 0.18 -22 0.145 Q9HBU1 A48T Polymorphism NA 0.278 0.75 -22 0.119 Q9HBV1 R106Q Polymorphism 0.130 0.069 0.16 -13 0.108 Q9HBW9 H599Q Polymorphism 0.563 0.449 0.26 32 0.553 Q9HBW9 V300L Polymorphism NA 0.281 0.67 -11 0.274 Q9HBX8 V592A Polymorphism 0.067 0.163 0.11 2 0.079 Q9HBY0 T171K Polymorphism 0.438 0.813 0.25 32 0.747 Q9HBY8 S12T Polymorphism NA 0.107 NA -3 0.053 Q9HBY8 H349Y Polymorphism 0.608 0.929 0.01 62 0.907 Q9HBZ2 G679S Polymorphism 0.061 0.170 0.85 -17 0.071 Q9HC10 A53V Polymorphism NA 0.087 NA -19 0.120 Q9HC10 A964E Disease 0.567 0.712 0.00 50 0.871 Q9HC10 I515T Disease 0.504 0.638 0.00 47 0.735 Q9HC10 P490Q Disease 0.745 0.480 0.01 36 0.716 Q9HC10 Q255H Disease 0.862 0.892 0.00 43 0.883 Q9HC10 R794H Disease 0.663 0.773 0.02 39 0.816 Q9HC10 R818W Polymorphism 0.714 0.293 0.01 44 0.572 Q9HC10 R822W Disease 0.879 0.314 0.02 33 0.591 Q9HC10 A1083P Polymorphism 0.365 0.572 0.24 0 0.427 Q9HC10 D1322E Polymorphism 0.149 0.134 1.00 0 0.126 Q9HC10 F1795C Disease 0.869 0.951 0.00 52 0.937 Q9HC10 G1888D Polymorphism 0.933 0.942 0.00 60 0.949 Q9HC10 L1011P Disease 0.779 0.987 0.01 34 0.867 Q9HC10 L1138P Disease 0.665 0.988 0.00 42 0.864 Q9HC10 P1646S Polymorphism 0.283 0.395 0.16 -12 0.315 Q9HC10 P1825A Disease 0.879 0.894 0.00 14 0.795 Q9HC10 P1987R Disease 0.952 0.923 0.00 67 0.953 Q9HC10 R1939Q Disease 0.864 0.949 0.00 26 0.878 Q9HC10 T1688K Polymorphism 0.566 0.897 0.01 53 0.842 Q9HC10 V1625M Polymorphism 0.373 0.291 0.02 13 0.386 Q9HC16 H186R Polymorphism 0.375 0.327 0.57 8 0.256 Q9HC16 Q275E Polymorphism 0.264 0.392 0.08 19 0.367 Q9HC21 G177A Disease 0.935 0.944 0.01 48 0.939 Q9HC23 G32R Disease 0.845 0.613 0.00 71 0.691 Q9HC23 R73C Disease 0.833 0.338 0.01 47 0.602 Q9HC24 A2V Polymorphism NA 0.077 0.15 -32 0.166 Q9HC29 L81V Polymorphism 0.444 0.181 0.00 45 0.274 Q9HC29 A612T Disease 0.341 0.877 0.01 20 0.666 Q9HC29 D382E Disease 0.275 0.804 0.14 6 0.469 Q9HC29 E383K Disease 0.355 0.811 0.01 55 0.826 Q9HC29 H496L Disease 0.484 0.247 1.00 -3 0.153 Q9HC29 L469F Disease 0.404 0.694 0.05 -3 0.543 Q9HC29 N289S Polymorphism 0.346 0.440 0.44 -28 0.293 Q9HC29 R334Q Disease 0.417 0.721 0.01 5 0.559 Q9HC29 R334W Disease 0.843 0.803 0.00 18 0.861 Q9HC29 R471C Polymorphism 0.116 0.750 0.03 -12 0.344 Q9HC29 V955I Polymorphism 0.092 0.392 0.19 -18 0.168 Q9HC35 K398R Polymorphism 0.706 0.353 0.50 -5 0.584 Q9HC35 S978L Polymorphism NA 0.085 0.00 11 0.146 Q9HC36 A8S Polymorphism NA 0.140 0.66 18 0.107 Q9HC36 G45E Polymorphism NA 0.101 1.00 1 0.086 Q9HC36 I185V Polymorphism 0.095 0.355 0.68 -14 0.205 Q9HC38 M282I Polymorphism 0.216 0.109 0.71 19 0.113 Q9HC52 G317V Polymorphism 0.359 0.066 0.01 -13 0.060 Q9HC58 L49P Polymorphism NA 0.312 0.14 7 0.224 Q9HC58 V55I Polymorphism 0.069 0.062 0.76 22 0.062 Q9HC58 V168I Polymorphism 0.407 0.057 0.64 -48 0.110 Q9HC62 T301K Polymorphism NA 0.111 1.00 -16 0.025 Q9HC77 D63H Polymorphism NA 0.127 0.04 45 0.156 Q9HC77 M21V Polymorphism NA 0.271 0.00 53 0.470 Q9HC77 P55A Polymorphism NA 0.092 0.00 38 0.178 Q9HC77 P85T Polymorphism NA 0.146 0.00 35 0.174 Q9HC77 E151G Polymorphism NA 0.160 0.00 38 0.380 Q9HC77 S879A Polymorphism NA 0.099 0.44 -27 0.071 Q9HC77 E1235V Disease NA 0.948 0.00 61 0.922 Q9HC84 R51W Polymorphism 0.286 0.209 0.02 47 0.316 Q9HC96 A341V Polymorphism 0.219 0.115 1.00 1 0.082 Q9HC96 R202H Polymorphism NA 0.341 0.14 -23 0.411 Q9HC97 A25T Polymorphism 0.186 0.238 0.30 8 0.255 Q9HC97 V29I Polymorphism 0.101 0.219 0.14 -28 0.232 Q9HC97 V76M Polymorphism 0.491 0.123 0.15 -33 0.241 Q9HC97 T108M Polymorphism 0.634 0.628 0.05 9 0.508 Q9HC97 T253M Polymorphism 0.128 0.379 0.20 25 0.297 Q9HCC0 E99Q Disease 0.449 0.791 0.03 45 0.749 Q9HCC0 A218T Disease 0.556 0.911 0.02 60 0.910 Q9HCC0 A478G Polymorphism 0.483 0.903 0.00 29 0.882 Q9HCC0 C167R Disease 0.642 0.938 0.02 46 0.904 Q9HCC0 I437V Disease 0.198 0.089 0.61 -23 0.182 Q9HCC0 P310R Disease 0.489 0.814 0.13 44 0.743 Q9HCC0 R155Q Disease 0.660 0.870 0.11 55 0.797 Q9HCC0 R193C Disease 0.834 0.936 0.05 42 0.902 Q9HCC0 R268T Disease NA 0.359 0.58 6 0.323 Q9HCC0 S173L Disease 0.722 0.907 0.01 53 0.908 Q9HCC0 V339M Disease 0.553 0.835 0.02 41 0.885 Q9HCC9 S603N Polymorphism 0.165 0.081 0.52 16 0.051 Q9HCC9 S672P Polymorphism 0.234 0.150 0.33 38 0.135 Q9HCE0 E844D Polymorphism NA 0.065 0.44 -15 0.072 Q9HCE0 A1511V Polymorphism NA 0.061 0.91 3 0.026 Q9HCE0 I1131V Polymorphism NA 0.142 1.00 9 0.117 Q9HCE0 R1985Q Polymorphism NA 0.061 0.60 33 0.065 Q9HCE0 S1864N Polymorphism NA 0.064 0.14 15 0.087 Q9HCE6 D69N Polymorphism NA 0.077 NA 10 0.058 Q9HCE7 S466Y Polymorphism 0.777 0.601 0.00 48 0.824 Q9HCF4 M270T Polymorphism 0.136 0.087 0.34 20 0.015 Q9HCF6 N1732T Polymorphism NA 0.152 NA 29 0.034 Q9HCG1 R7Q Polymorphism NA 0.261 0.37 -19 0.192 Q9HCG8 A656V Polymorphism 0.383 0.152 0.18 7 0.223 Q9HCG8 D741V Polymorphism 0.216 0.110 0.24 17 0.088 Q9HCG8 R794Q Polymorphism 0.107 0.122 0.11 34 0.095 Q9HCI5 E339D Polymorphism NA 0.097 0.49 24 0.063 Q9HCI6 F75L Polymorphism NA 0.514 NA 8 0.367 Q9HCI6 V81M Polymorphism NA 0.095 NA 21 0.045 Q9HCJ1 P5L Disease NA 0.574 0.00 31 0.509 Q9HCJ1 P5T Disease NA 0.459 0.00 38 0.402 Q9HCJ1 M48T Disease NA 0.444 0.00 -35 0.164 Q9HCJ1 C331R Disease NA 0.889 0.00 53 0.859 Q9HCJ1 G389R Disease NA 0.342 0.01 49 0.364 Q9HCJ1 W292R Disease NA 0.892 0.00 60 0.863 Q9HCK1 R160K Polymorphism 0.208 0.039 NA -33 0.025 Q9HCK4 I945T Disease 0.466 0.247 1.00 13 0.230 Q9HCK4 A1236T Disease NA 0.075 0.11 3 0.078 Q9HCL2 S4Y Polymorphism NA 0.141 0.00 14 0.176 Q9HCL2 I43V Polymorphism 0.057 0.053 0.94 -53 0.018 Q9HCL2 I386T Polymorphism 0.196 0.371 0.09 0 0.309 Q9HCM1 H106Q Polymorphism NA 0.264 0.00 41 0.122 Q9HCM1 I202V Polymorphism NA 0.100 0.36 -12 0.020 Q9HCM1 S346N Polymorphism 0.313 0.072 NA 20 0.082 Q9HCM1 S352G Polymorphism 0.279 0.062 0.12 10 0.068 Q9HCM1 S433T Polymorphism 0.264 0.069 0.00 23 0.165 Q9HCM1 T1010K Polymorphism 0.438 0.072 0.77 32 0.050 Q9HCM1 T1338A Polymorphism NA 0.024 0.52 0 0.028 Q9HCM1 V1226I Polymorphism 0.333 0.062 0.66 -31 0.027 Q9HCM4 A462T Polymorphism 0.728 0.091 0.97 -35 0.085 Q9HCM4 H334Y Polymorphism 0.754 0.523 1.00 -1 0.691 Q9HCN3 R567W Polymorphism 0.788 0.616 0.00 38 0.769 Q9HCP6 M403V Polymorphism 0.352 0.042 1.00 -5 0.022 Q9HCQ7 D42G Polymorphism 0.446 0.282 0.59 7 0.121 Q9HCR9 R804H Polymorphism 0.516 0.825 0.21 52 0.674 Q9HCS4 G533R Polymorphism NA 0.153 0.35 46 0.176 Q9HCS5 V132I Polymorphism 0.526 0.553 0.40 -10 0.365 Q9HCS7 A702T Polymorphism 0.164 0.149 0.59 -2 0.097 Q9HCS7 V126I Polymorphism 0.092 0.085 0.55 24 0.120 Q9HCU4 Y1639H Polymorphism NA 0.230 0.45 27 0.349 Q9HCU8 G59R Polymorphism NA 0.639 0.00 60 0.695 Q9HCU8 R39P Polymorphism NA 0.184 0.15 0 0.025 Q9HCX3 L121P Polymorphism 0.253 0.273 0.38 12 0.231 Q9HD23 P35S Polymorphism 0.153 0.132 0.35 21 0.044 Q9HD33 C10G Polymorphism NA 0.462 0.00 22 0.242 Q9HD33 R213H Polymorphism 0.667 0.226 0.10 -8 0.518 Q9HD34 S11A Polymorphism 0.266 0.194 0.54 -5 0.253 Q9HD43 H348Y Polymorphism NA 0.203 0.03 56 0.336 Q9HD43 K781N Polymorphism NA 0.481 0.87 19 0.397 Q9HD43 I1076V Polymorphism 0.144 0.695 0.78 -20 0.187 Q9HD67 V32I Polymorphism 0.158 0.194 0.29 11 0.241 Q9HD67 E273D Polymorphism 0.173 0.400 0.22 15 0.262 Q9HD67 R324W Polymorphism 0.264 0.736 0.24 36 0.342 Q9HD67 R700Q Polymorphism 0.348 0.421 0.11 32 0.407 Q9HD90 K68T Polymorphism 0.704 0.410 0.01 30 0.578 Q9HDC5 D624H Polymorphism 0.739 0.071 0.28 27 0.082 Q9HDC5 T507M Polymorphism 0.493 0.135 0.03 22 0.156 Q9HDC9 I65V Polymorphism NA 0.084 NA 7 0.178 Q9HDC9 R282Q Polymorphism 0.230 0.349 0.37 3 0.282 Q9HDC9 R374W Polymorphism 0.552 0.449 0.04 -7 0.559 Q9NNX1 K296R Polymorphism 0.258 0.240 0.63 -14 0.283 Q9NNX6 A382S Polymorphism NA 0.758 0.29 1 0.548 Q9NNX6 L242V Polymorphism NA 0.852 0.43 -9 0.635 Q9NNZ6 Q100R Polymorphism 0.112 0.058 0.00 19 0.135 Q9NP31 N52S Polymorphism NA 0.054 0.72 -23 0.028 Q9NP31 R272C Polymorphism 0.733 0.192 0.01 27 0.374 Q9NP58 L293V Polymorphism 0.533 0.488 0.58 37 0.540 Q9NP59 A77D Disease NA 0.592 0.03 40 0.751 Q9NP59 G80V Disease NA 0.989 0.00 60 0.887 Q9NP59 Y64N Disease NA 0.911 0.04 44 0.846 Q9NP59 D157G Disease NA 0.958 0.01 47 0.698 Q9NP59 D181V Disease NA 0.907 0.00 55 0.841 Q9NP59 D270V Disease NA 0.265 0.48 47 0.390 Q9NP59 G267D Disease NA 0.214 0.10 24 0.220 Q9NP59 G323V Disease NA 0.763 0.08 23 0.778 Q9NP59 N144D Disease NA 0.388 0.64 3 0.385 Q9NP59 N144H Disease NA 0.275 0.19 -20 0.329 Q9NP59 N144T Disease NA 0.372 0.71 -13 0.362 Q9NP59 Q182H Disease NA 0.383 0.03 53 0.670 Q9NP59 Q248H Polymorphism NA 0.142 0.31 22 0.212 Q9NP61 A482T Polymorphism 0.687 0.413 0.22 4 0.493 Q9NP61 Q468H Polymorphism 0.479 0.132 0.47 30 0.127 Q9NP61 S231G Polymorphism 0.175 0.221 0.48 -39 0.171 Q9NP61 S355R Polymorphism 0.535 0.252 0.73 20 0.454 Q9NP70 L354P Polymorphism 0.799 0.600 0.00 -13 0.724 Q9NP71 D244E Polymorphism 0.261 0.487 0.09 -23 0.381 Q9NP71 Q241H Polymorphism 0.533 0.122 0.04 -22 0.099 Q9NP72 A198T Polymorphism NA 0.224 0.67 0 0.234 Q9NP72 N113S Polymorphism 0.152 0.631 0.14 -8 0.253 Q9NP74 H73Q Polymorphism 0.671 0.047 0.33 -27 0.065 Q9NP74 N229S Polymorphism NA 0.749 0.33 18 0.551 Q9NP78 V121M Polymorphism NA 0.157 0.10 1 0.255 Q9NP79 I239M Polymorphism 0.294 0.161 0.02 -8 0.275 Q9NP81 S83L Polymorphism NA 0.173 0.28 4 0.188 Q9NP81 T35A Polymorphism NA 0.059 1.00 0 0.029 Q9NP85 G92C Disease NA 0.378 0.02 35 0.536 Q9NP85 P20L Disease NA 0.121 0.12 2 0.104 Q9NP85 D160G Disease 0.721 0.574 0.01 47 0.828 Q9NP85 R138Q Disease 0.879 0.926 0.03 54 0.900 Q9NP85 R291W Disease 0.917 0.767 0.02 35 0.859 Q9NP85 V180M Disease 0.548 0.458 0.07 29 0.424 Q9NP86 E140K Polymorphism 0.256 0.850 0.05 45 0.591 Q9NP87 G220A Polymorphism 0.807 0.748 0.00 17 0.826 Q9NP87 V246F Polymorphism 0.714 0.906 0.01 63 0.791 Q9NP91 A9G Polymorphism 0.051 0.210 0.51 -63 0.114 Q9NP91 T199M Polymorphism 0.895 0.876 0.00 27 0.873 Q9NP94 L48P Polymorphism 0.680 0.964 0.21 38 0.869 Q9NP94 M80V Polymorphism NA 0.034 0.31 33 0.064 Q9NP94 H154Y Polymorphism 0.394 0.451 0.16 34 0.561 Q9NP95 D206N Polymorphism 0.516 0.404 0.00 26 0.624 Q9NP95 G116R Polymorphism 0.903 0.841 0.19 48 0.871 Q9NP95 P175A Polymorphism 0.405 0.562 0.29 8 0.454 Q9NP97 I71F Polymorphism 0.731 0.472 NA 34 0.687 Q9NP97 S13R Polymorphism 0.430 0.569 NA 20 0.732 Q9NP99 F214L Polymorphism 0.150 0.123 1.00 -21 0.031 Q9NP99 K135T Polymorphism 0.368 0.224 0.34 33 0.213 Q9NPA1 A53T Polymorphism 0.212 0.325 0.33 27 0.404 Q9NPA1 L75V Polymorphism 0.241 0.141 0.20 -24 0.115 Q9NPA1 N165S Polymorphism 0.296 0.106 0.27 -6 0.191 Q9NPA5 F425Y Polymorphism 0.103 0.263 1.00 6 0.216 Q9NPB6 V286I Polymorphism 0.154 0.129 0.28 6 0.130 Q9NPC4 M37V Polymorphism 0.135 0.129 0.10 -32 0.047 Q9NPC4 G187D Polymorphism 0.912 0.990 0.00 72 0.958 Q9NPC4 P251L Polymorphism 0.515 0.953 0.00 50 0.898 Q9NPC4 Q163R Polymorphism 0.171 0.354 0.67 2 0.133 Q9NPD5 M233I Polymorphism 0.108 0.470 1.00 -50 0.128 Q9NPD5 S112A Polymorphism 0.192 0.156 1.00 -50 0.117 Q9NPE3 R34W Disease 0.936 0.911 0.00 55 0.945 Q9NPF0 Q8R Polymorphism NA 0.094 NA -55 0.020 Q9NPF0 G220R Polymorphism NA 0.151 0.08 52 0.066 Q9NPG4 S640N Polymorphism 0.154 0.702 0.22 19 0.232 Q9NPG8 V53M Polymorphism NA 0.152 0.30 -7 0.099 Q9NPH3 V473M Polymorphism 0.621 0.260 0.16 39 0.490 Q9NPH6 V167I Polymorphism 0.185 0.026 0.53 -8 0.061 Q9NPI5 E178K Polymorphism 0.325 0.364 0.56 -5 0.250 Q9NPJ1 G49V Polymorphism 0.453 0.655 0.16 20 0.725 Q9NPJ1 G52D Disease 0.701 0.354 0.91 54 0.411 Q9NPJ1 H84Y Disease 0.571 0.453 0.00 50 0.646 Q9NPJ1 I32M Disease 0.444 0.432 0.24 38 0.345 Q9NPJ1 T57A Disease 0.341 0.883 0.00 60 0.885 Q9NPJ1 Y37C Disease 0.849 0.734 0.00 48 0.879 Q9NPJ1 A181P Disease 0.635 0.985 0.00 62 0.886 Q9NPJ1 A242S Disease 0.228 0.621 0.05 11 0.481 Q9NPJ1 C499S Disease 0.308 0.445 0.01 49 0.316 Q9NPJ1 D286A Disease 0.497 0.191 0.58 28 0.242 Q9NPJ1 D492N Disease 0.296 0.174 0.03 40 0.253 Q9NPJ1 G345E Disease 0.687 0.961 0.00 61 0.923 Q9NPJ1 G532V Polymorphism NA 0.148 0.00 40 0.160 Q9NPJ1 I339V Disease 0.080 0.264 0.06 31 0.196 Q9NPJ1 L277P Disease 0.766 0.863 0.28 48 0.848 Q9NPJ1 R155L Disease 0.368 0.310 0.82 47 0.425 Q9NPJ1 R518H Disease 0.073 0.040 0.60 -5 0.012 Q9NPJ1 S236P Disease 0.332 0.552 0.04 25 0.517 Q9NPJ1 S460P Disease 0.613 0.701 0.02 56 0.889 Q9NPJ1 S511A Disease 0.202 0.112 0.00 -2 0.126 Q9NPJ1 T237A Disease 0.105 0.075 0.16 -23 0.083 Q9NPJ1 T237P Disease 0.302 0.331 0.06 5 0.360 Q9NPR2 S792A Polymorphism 0.033 0.072 NA 29 0.050 Q9NPR9 L79P Polymorphism NA 0.250 0.15 -39 0.157 Q9NPY3 P541S Polymorphism 0.059 0.078 1.00 -23 0.083 Q9NQ11 R762W Polymorphism 0.791 0.928 0.00 54 0.935 Q9NQ31 R23K Polymorphism NA 0.195 NA 8 0.325 Q9NQ31 I132T Polymorphism NA 0.083 NA -3 0.069 Q9NQ32 P144L Polymorphism NA 0.090 NA 7 0.074 Q9NQ33 R54L Polymorphism NA 0.031 0.71 -4 0.027 Q9NQ36 T591M Polymorphism 0.072 0.474 0.57 -10 0.220 Q9NQ38 I588M Polymorphism 0.645 0.750 0.01 47 0.858 Q9NQ38 K969E Polymorphism NA 0.161 0.29 61 0.183 Q9NQ38 Q267R Polymorphism 0.600 0.118 1.00 28 0.109 Q9NQ38 S887R Polymorphism NA 0.217 0.11 56 0.369 Q9NQ38 V395M Polymorphism 0.418 0.114 0.00 -4 0.205 Q9NQ40 I303V Polymorphism 0.307 0.348 0.14 20 0.306 Q9NQ48 D246N Polymorphism 0.166 0.198 NA 11 0.285 Q9NQ48 K152E Polymorphism 0.158 0.385 NA 11 0.394 Q9NQ50 R129H Polymorphism 0.111 0.033 NA -39 0.014 Q9NQ55 G358V Polymorphism 0.365 0.162 0.20 8 0.186 Q9NQ55 Q408R Polymorphism 0.119 0.016 0.49 -24 0.011 Q9NQ60 T274K Polymorphism NA 0.214 NA 51 0.267 Q9NQ66 E854K Polymorphism 0.211 0.103 0.62 4 0.138 Q9NQ75 R491K Polymorphism 0.065 0.129 0.53 13 0.132 Q9NQ75 T629N Polymorphism 0.182 0.062 0.47 15 0.029 Q9NQ76 V330I Polymorphism 0.103 0.066 NA -43 0.071 Q9NQ79 A253T Polymorphism 0.236 0.112 NA 38 0.275 Q9NQ86 K428R Polymorphism NA 0.160 0.61 3 0.120 Q9NQ86 N456S Polymorphism NA 0.273 0.52 19 0.299 Q9NQ94 V555M Polymorphism NA 0.250 0.11 29 0.138 Q9NQA5 A8V Polymorphism NA 0.072 0.13 -16 0.088 Q9NQA5 L712F Polymorphism 0.294 0.073 0.07 36 0.094 Q9NQA5 R154H Polymorphism 0.222 0.428 0.05 25 0.311 Q9NQB0 K346N Polymorphism 0.775 0.686 0.01 26 0.710 Q9NQC1 R581G Polymorphism 0.443 0.217 0.21 3 0.176 Q9NQC7 E747G Disease 0.711 0.520 NA 38 0.712 Q9NQC8 C9Y Polymorphism NA 0.058 1.00 -19 0.027 Q9NQE7 A204G Polymorphism 0.293 0.468 1.00 -39 0.291 Q9NQF3 E3K Polymorphism NA 0.080 NA -21 0.089 Q9NQG6 G78R Polymorphism NA 0.171 0.02 0 0.199 Q9NQG6 D264N Polymorphism NA 0.147 0.06 12 0.088 Q9NQG6 R169W Polymorphism NA 0.238 0.01 26 0.360 Q9NQG7 E229G Polymorphism 0.127 0.053 NA -14 0.081 Q9NQG7 H606Y Polymorphism 0.212 0.517 NA 47 0.512 Q9NQG7 L443V Polymorphism 0.181 0.050 NA -31 0.054 Q9NQG7 Q625H Polymorphism 0.157 0.246 NA 29 0.202 Q9NQH7 I450L Polymorphism NA 0.623 0.08 39 0.675 Q9NQL9 A164T Polymorphism 0.099 0.104 0.37 -34 0.079 Q9NQL9 G356V Polymorphism 0.198 0.079 0.22 -29 0.009 Q9NQN1 R123H Polymorphism 0.588 0.928 0.03 63 0.840 Q9NQN1 V287A Polymorphism 0.482 0.440 0.01 21 0.466 Q9NQR4 V231A Polymorphism 0.789 0.715 0.01 43 0.853 Q9NQR9 S324P Polymorphism 0.778 0.812 0.14 23 0.848 Q9NQS1 Q228R Polymorphism 0.175 0.203 NA 7 0.219 Q9NQS7 G2V Polymorphism 0.332 0.454 NA 18 0.323 Q9NQS7 R100H Polymorphism 0.195 0.064 0.02 -13 0.073 Q9NQT4 T5M Polymorphism 0.306 0.040 0.07 24 0.035 Q9NQT4 C33W Polymorphism 0.905 0.785 0.01 68 0.921 Q9NQT5 Y225H Polymorphism 0.516 0.250 0.38 0 0.507 Q9NQT6 A24S Polymorphism 0.268 0.140 0.72 19 0.136 Q9NQU5 E184K Polymorphism NA 0.252 0.24 51 0.113 Q9NQU5 E475K Polymorphism 0.261 0.428 0.50 8 0.357 Q9NQU5 G205E Polymorphism NA 0.053 0.23 43 0.051 Q9NQU5 H215R Polymorphism NA 0.055 0.62 12 0.022 Q9NQU5 P208T Polymorphism NA 0.123 0.02 43 0.161 Q9NQU5 P337L Polymorphism NA 0.121 0.09 27 0.126 Q9NQU5 R103C Polymorphism NA 0.181 0.01 45 0.348 Q9NQU5 T210M Polymorphism NA 0.071 0.13 38 0.047 Q9NQV7 Y335H Polymorphism NA 0.416 0.64 15 0.458 Q9NQW1 V89A Polymorphism 0.165 0.115 1.00 5 0.123 Q9NQW1 L129F Polymorphism 0.177 0.145 1.00 -28 0.069 Q9NQW1 R478T Polymorphism 0.740 0.812 0.00 48 0.736 Q9NQW1 A1169S Polymorphism 0.279 0.076 0.26 -36 0.085 Q9NQW5 N435K Polymorphism NA 0.069 NA 36 0.055 Q9NQW6 R185K Polymorphism NA 0.021 1.00 -38 0.006 Q9NQW8 R25H Polymorphism NA 0.177 0.15 39 0.023 Q9NQW8 D494N Disease 0.581 0.710 0.14 42 0.538 Q9NQW8 D513Y Disease 0.720 0.783 0.01 49 0.679 Q9NQW8 E199K Disease NA 0.537 0.65 53 0.546 Q9NQW8 E755G Polymorphism 0.116 0.061 0.09 30 0.076 Q9NQW8 F525N Disease 0.998 0.917 0.00 49 0.824 Q9NQW8 G107R Disease NA 0.054 0.12 42 0.065 Q9NQW8 G558C Disease 0.880 0.825 0.04 60 0.748 Q9NQW8 K148E Disease NA 0.124 0.84 -7 0.036 Q9NQW8 L595F Disease 0.568 0.819 0.02 60 0.683 Q9NQW8 M466T Disease 0.406 0.927 0.00 54 0.617 Q9NQW8 P309L Disease 0.999 0.934 0.00 44 0.937 Q9NQW8 R203Q Disease NA 0.414 0.10 -2 0.251 Q9NQW8 S156F Disease NA 0.358 0.03 12 0.473 Q9NQW8 S435F Disease 0.738 0.909 0.00 37 0.826 Q9NQW8 T672P Disease 0.414 0.857 0.26 1 0.682 Q9NQW8 Y469D Disease 0.737 0.831 0.05 53 0.764 Q9NQX3 N10Y Disease 0.494 0.309 NA 39 0.279 Q9NQX4 P1396L Polymorphism 0.292 0.863 0.00 -5 0.684 Q9NQZ2 T23M Polymorphism NA 0.130 0.00 16 0.162 Q9NQZ5 R140P Polymorphism 0.256 0.148 0.24 8 0.055 Q9NQZ8 R27G Polymorphism 0.267 0.222 0.37 24 0.257 Q9NQZ8 V105I Polymorphism 0.080 0.117 0.21 0 0.128 Q9NR16 G582A Polymorphism 0.362 0.555 0.80 15 0.220 Q9NR16 G1055S Polymorphism 0.242 0.754 0.04 38 0.467 Q9NR16 M1108T Polymorphism 0.212 0.147 0.64 19 0.130 Q9NR20 A70S Polymorphism 0.421 0.816 0.23 -10 0.558 Q9NR20 V95I Polymorphism 0.107 0.285 0.45 -17 0.227 Q9NR20 N189S Polymorphism 0.453 0.490 0.25 37 0.458 Q9NR23 G213R Polymorphism 0.063 0.444 0.53 -28 0.197 Q9NR33 G17V Polymorphism NA 0.049 0.00 -18 0.066 Q9NR46 P319L Polymorphism NA 0.102 0.05 30 0.197 Q9NR48 S1416P Polymorphism NA 0.149 0.06 31 0.109 Q9NR50 A87V Disease 0.813 0.824 0.06 9 0.663 Q9NR50 R225Q Disease 0.413 0.269 0.09 58 0.339 Q9NR55 V11I Polymorphism 0.050 0.101 0.28 11 0.050 Q9NR63 A420G Polymorphism 0.256 0.137 0.38 -17 0.191 Q9NR63 L264S Polymorphism 0.092 0.326 0.72 10 0.184 Q9NR63 V181M Polymorphism 0.600 0.544 0.08 29 0.557 Q9NR63 V479I Polymorphism NA 0.034 0.82 -18 0.061 Q9NR80 D33H Polymorphism NA 0.155 NA -1 0.125 Q9NR96 H79Q Polymorphism NA 0.244 0.12 25 0.232 Q9NR96 A882T Polymorphism NA 0.590 0.07 38 0.604 Q9NR99 V764L Polymorphism NA 0.066 0.32 36 0.089 Q9NR99 P1665S Polymorphism NA 0.117 0.34 42 0.096 Q9NR99 T1484A Polymorphism NA 0.100 0.16 32 0.050 Q9NRA0 R652Q Polymorphism NA 0.192 0.00 16 0.105 Q9NRA2 R39C Disease 0.998 0.967 0.00 75 0.958 Q9NRA2 G371V Disease 0.683 0.858 0.05 34 0.763 Q9NRA2 H183R Disease 0.809 0.628 0.36 60 0.899 Q9NRA2 K136E Disease 0.512 0.936 0.34 53 0.682 Q9NRA2 P334R Disease 0.998 0.840 0.20 65 0.935 Q9NRB3 P94L Polymorphism 0.183 0.067 0.79 -1 0.068 Q9NRB3 A145P Polymorphism 0.327 0.358 0.22 1 0.347 Q9NRB3 R109S Polymorphism 0.041 0.117 0.77 5 0.098 Q9NRC1 A186T Polymorphism 0.215 0.352 0.12 -7 0.405 Q9NRC1 I361V Polymorphism 0.203 0.696 0.06 -46 0.443 Q9NRC6 A3275G Polymorphism NA 0.664 0.59 28 0.448 Q9NRC6 Q2862R Polymorphism NA 0.135 0.78 3 0.210 Q9NRC6 R1345H Polymorphism 0.421 0.346 0.16 32 0.330 Q9NRC6 R1367T Polymorphism 0.300 0.490 0.41 3 0.238 Q9NRD1 P201T Polymorphism NA 0.098 0.44 19 0.198 Q9NRD8 Q36H Disease NA 0.332 0.00 50 0.638 Q9NRD8 R376W Disease NA 0.731 0.04 25 0.770 Q9NRD9 I962T Polymorphism 0.385 0.291 0.53 -12 0.243 Q9NRD9 C1026R Polymorphism NA 0.547 0.35 16 0.309 Q9NRD9 L1178F Polymorphism NA 0.692 0.98 -30 0.375 Q9NRE2 A681T Polymorphism 0.324 0.246 0.33 3 0.371 Q9NRF2 V541A Polymorphism 0.236 0.866 0.01 23 0.730 Q9NRF9 D126A Polymorphism 0.262 0.118 0.80 13 0.086 Q9NRG0 C55Y Polymorphism 0.602 0.246 0.97 -27 0.342 Q9NRG0 H126R Polymorphism 0.156 0.058 0.03 -27 0.044 Q9NRG4 G165E Polymorphism 0.164 0.230 0.35 5 0.197 Q9NRG7 G207V Polymorphism 0.674 0.826 0.01 43 0.838 Q9NRG9 Q15K Disease 0.520 0.157 NA -2 0.118 Q9NRG9 H160R Disease 0.449 0.910 0.15 60 0.902 Q9NRG9 S263P Disease 0.168 0.880 0.01 58 0.742 Q9NRH2 L260S Polymorphism 0.224 0.436 0.04 39 0.549 Q9NRH2 P391S Polymorphism 0.199 0.341 0.06 -3 0.244 Q9NRI5 G5V Polymorphism NA 0.288 NA 36 0.217 Q9NRI5 L330F Polymorphism 0.579 0.331 NA 31 0.534 Q9NRI5 S704C Polymorphism 0.732 0.150 NA 15 0.257 Q9NRJ4 D979N Polymorphism 0.254 0.223 NA 31 0.231 Q9NRJ4 S522N Polymorphism 0.138 0.073 NA -11 0.074 Q9NRK6 A150S Polymorphism 0.138 0.216 0.74 -34 0.164 Q9NRK6 D545N Polymorphism 0.240 0.877 0.07 4 0.226 Q9NRK6 R242G Polymorphism 0.700 0.906 0.17 46 0.809 Q9NRL2 D344E Polymorphism 0.144 0.140 1.00 10 0.101 Q9NRL2 N1366K Polymorphism NA 0.067 0.03 13 0.074 Q9NRM0 S22N Polymorphism 0.075 0.055 0.47 -10 0.024 Q9NRM0 T275M Polymorphism 0.386 0.489 0.21 -25 0.455 Q9NRM0 V282I Polymorphism 0.158 0.182 0.23 -10 0.172 Q9NRM1 I648T Polymorphism 0.064 0.153 0.79 -40 0.056 Q9NRM1 P724L Polymorphism 0.664 0.728 0.01 23 0.691 Q9NRM6 A209V Polymorphism NA 0.078 1.00 -8 0.058 Q9NRM6 C499R Polymorphism NA 0.632 0.18 64 0.792 Q9NRM6 G177R Polymorphism NA 0.583 0.00 52 0.744 Q9NRM7 S91L Polymorphism NA 0.239 0.00 13 0.238 Q9NRM7 A324V Polymorphism NA 0.095 0.09 29 0.096 Q9NRM7 L1025P Polymorphism NA 0.737 0.05 20 0.574 Q9NRP2 T11S Polymorphism 0.251 0.398 0.00 8 0.267 Q9NRP7 I90M Polymorphism 0.291 0.163 0.01 19 0.300 Q9NRP7 D329N Polymorphism 0.311 0.090 0.02 40 0.132 Q9NRP7 K295R Polymorphism 0.200 0.218 0.05 24 0.214 Q9NRP7 L462V Polymorphism 0.162 0.132 0.00 15 0.153 Q9NRP7 Q638P Polymorphism 0.091 0.057 1.00 -42 0.013 Q9NRP7 R240W Polymorphism 0.646 0.577 0.00 24 0.744 Q9NRP7 R477W Polymorphism 0.666 0.279 0.00 43 0.474 Q9NRP7 R839Q Polymorphism 0.278 0.147 0.00 -9 0.162 Q9NRP7 S767T Polymorphism 0.176 0.284 0.00 -14 0.147 Q9NRP7 G1003D Polymorphism 0.141 0.231 0.00 16 0.200 Q9NRP7 H1313P Polymorphism 0.518 0.131 0.00 23 0.219 Q9NRQ2 I155V Polymorphism 0.061 0.166 0.55 19 0.152 Q9NRR1 S51L Polymorphism NA 0.078 NA -3 0.047 Q9NRR2 I126M Polymorphism 0.434 0.654 0.00 38 0.669 Q9NRR2 W160S Polymorphism 0.659 0.462 0.18 54 0.677 Q9NRR4 P67T Polymorphism NA 0.119 0.03 32 0.149 Q9NRS6 R334C Polymorphism 0.544 0.050 0.04 39 0.104 Q9NRX1 G71A Polymorphism 0.128 0.259 0.52 2 0.219 Q9NRX5 L199V Polymorphism 0.242 0.344 0.70 -49 0.264 Q9NRX5 S225G Polymorphism 0.177 0.276 1.00 -12 0.170 Q9NS23 K21Q Polymorphism NA 0.067 0.18 7 0.016 Q9NS23 R53C Polymorphism NA 0.173 0.15 37 0.121 Q9NS23 A137S Polymorphism 0.212 0.079 0.13 -38 0.141 Q9NS23 D133E Polymorphism NA 0.027 0.84 -11 0.026 Q9NS23 H319R Polymorphism 0.490 0.130 0.09 23 0.150 Q9NS23 Y329C Polymorphism 0.280 0.229 0.15 20 0.302 Q9NS25 V74L Polymorphism 0.122 0.088 0.62 -7 0.043 Q9NS39 A626T Polymorphism 0.405 0.453 0.32 8 0.360 Q9NS40 G958A Polymorphism 0.081 0.061 0.42 -10 0.066 Q9NS56 E517K Polymorphism 0.130 0.024 0.00 32 0.091 Q9NS62 K768R Polymorphism 0.067 0.048 1.00 -36 0.056 Q9NS62 R224G Polymorphism 0.327 0.361 0.00 25 0.525 Q9NS62 V125G Polymorphism 0.556 0.758 0.00 52 0.853 Q9NS68 S31T Polymorphism NA 0.018 0.08 -46 0.013 Q9NS68 V405I Polymorphism NA 0.032 NA 12 0.028 Q9NS73 L7H Polymorphism NA 0.085 NA -9 0.046 Q9NS73 R22S Polymorphism NA 0.088 NA 7 0.029 Q9NS82 R413Q Polymorphism 0.196 0.368 0.19 6 0.283 Q9NS86 I74V Polymorphism 0.135 0.091 0.60 -4 0.057 Q9NS87 A211V Polymorphism 0.351 0.198 1.00 -35 0.150 Q9NS87 T996S Polymorphism NA 0.068 0.99 -42 0.031 Q9NS87 E1272D Polymorphism NA 0.146 0.09 11 0.049 Q9NS87 L1206M Polymorphism NA 0.127 0.15 -50 0.069 Q9NS91 E6A Polymorphism 0.361 0.326 0.31 31 0.494 Q9NS93 P248L Polymorphism NA 0.221 NA 9 0.346 Q9NS98 I232T Polymorphism 0.385 0.867 0.00 60 0.911 Q9NS98 V332I Polymorphism 0.147 0.221 0.04 0 0.196 Q9NSA1 G141S Polymorphism 0.468 0.298 0.52 16 0.375 Q9NSB2 I206V Polymorphism 0.296 0.056 0.50 -18 0.098 Q9NSB2 R184Q Polymorphism 0.606 0.911 0.10 27 0.644 Q9NSB2 S198N Polymorphism 0.279 0.258 0.52 -52 0.251 Q9NSC2 S159G Polymorphism NA 0.241 0.06 33 0.224 Q9NSC2 G1265E Polymorphism 0.527 0.268 1.00 57 0.570 Q9NSC7 I424V Polymorphism 0.182 0.075 0.54 -1 0.097 Q9NSD5 V426I Polymorphism 0.077 0.319 0.53 -50 0.192 Q9NSE4 A14V Polymorphism NA 0.186 0.00 18 0.168 Q9NSE4 I522V Polymorphism 0.463 0.289 0.03 39 0.424 Q9NSE7 S228N Polymorphism NA 0.055 0.11 -3 0.073 Q9NSI5 D350E Polymorphism NA 0.026 0.14 -21 0.005 Q9NSI5 N156K Polymorphism NA 0.133 0.05 29 0.120 Q9NSI5 R170W Polymorphism NA 0.196 0.01 23 0.205 Q9NSI6 Q83E Polymorphism 0.079 0.126 0.31 48 0.115 Q9NSI8 G63A Polymorphism NA 0.159 1.00 -7 0.180 Q9NST1 C99G Polymorphism 0.220 0.245 0.34 -4 0.194 Q9NST1 G115C Polymorphism 0.550 0.428 0.12 11 0.509 Q9NST1 I148M Polymorphism 0.406 0.718 0.02 59 0.826 Q9NST1 T216P Polymorphism 0.527 0.656 0.10 16 0.535 Q9NSU2 D73N Disease 0.639 0.818 0.00 67 0.851 Q9NSU2 D255N Disease 0.418 0.603 0.00 55 0.734 Q9NSU2 E321G Polymorphism 0.233 0.041 0.40 3 0.030 Q9NSU2 R169H Disease 0.621 0.456 0.00 -9 0.463 Q9NSU2 V256D Disease 0.692 0.841 0.00 46 0.873 Q9NSY1 D212V Polymorphism 0.559 0.134 0.02 34 0.443 Q9NSY1 G405S Polymorphism 0.054 0.142 0.33 -6 0.107 Q9NSY1 R288H Polymorphism 0.062 0.546 0.04 30 0.048 Q9NSY1 T1002S Polymorphism 0.284 0.202 0.00 -28 0.159 Q9NSY2 G74S Polymorphism 0.423 0.211 0.72 -10 0.335 Q9NT22 S532N Polymorphism 0.260 0.056 0.49 -36 0.047 Q9NT68 N728S Polymorphism 0.277 0.373 NA 31 0.311 Q9NT68 V1719F Polymorphism 0.399 0.294 NA 29 0.430 Q9NTG1 V26A Polymorphism NA 0.070 NA -1 0.041 Q9NTG1 L914P Polymorphism NA 0.156 0.13 -13 0.025 Q9NTG1 V993A Polymorphism NA 0.125 0.67 -10 0.069 Q9NTG1 I1147M Polymorphism NA 0.136 0.01 49 0.132 Q9NTG1 N1091S Polymorphism NA 0.107 0.18 0 0.093 Q9NTG1 N1411D Polymorphism NA 0.199 0.52 -26 0.162 Q9NTG1 V1729I Polymorphism 0.102 0.286 0.12 20 0.169 Q9NTG7 R80W Polymorphism NA 0.110 NA 10 0.092 Q9NTG7 G369S Polymorphism 0.764 0.335 0.40 -14 0.578 Q9NTI2 A1029T Polymorphism NA 0.181 0.41 -14 0.230 Q9NTJ3 E415D Polymorphism 0.495 0.484 0.17 4 0.448 Q9NTJ3 N356S Polymorphism 0.198 0.453 0.62 -40 0.203 Q9NTJ3 S181R Polymorphism 0.643 0.561 0.03 40 0.742 Q9NTJ4 V950M Polymorphism 0.449 0.419 0.31 -5 0.402 Q9NTJ4 V960I Polymorphism 0.129 0.068 1.00 -23 0.059 Q9NTK1 I44M Polymorphism NA 0.203 0.00 50 0.367 Q9NTQ9 E204A Polymorphism 0.996 0.950 0.00 47 0.932 Q9NTQ9 F137L Disease 0.444 0.851 0.04 -29 0.511 Q9NTQ9 R103C Polymorphism 0.826 0.823 0.00 25 0.843 Q9NTX9 Y380C Polymorphism NA 0.475 NA 56 0.581 Q9NU02 L324Q Polymorphism NA 0.546 0.30 51 0.737 Q9NU02 R742Q Polymorphism NA 0.097 0.52 7 0.105 Q9NU22 F440V Polymorphism 0.200 0.392 0.23 44 0.290 Q9NU22 A1044V Polymorphism 0.387 0.223 0.23 35 0.232 Q9NU22 A4044S Polymorphism 0.243 0.085 0.34 -17 0.121 Q9NU22 A4167T Polymorphism NA 0.049 0.14 -42 0.117 Q9NU22 D4783E Polymorphism 0.210 0.285 0.22 3 0.264 Q9NU22 H2972P Polymorphism 0.422 0.169 NA 43 0.180 Q9NU22 I4720T Polymorphism 0.310 0.189 0.09 17 0.279 Q9NU22 N5251K Polymorphism 0.212 0.112 0.12 31 0.255 Q9NU22 R3986L Polymorphism 0.392 0.284 0.01 -7 0.248 Q9NU23 T60P Polymorphism 0.540 0.370 0.01 36 0.610 Q9NU63 H193N Disease 0.626 0.246 0.00 66 0.873 Q9NU63 H374D Disease 0.652 0.823 0.00 84 0.994 Q9NU63 N114S Polymorphism 0.078 0.198 0.16 -28 0.123 Q9NU63 R166H Disease 0.255 0.162 0.17 -3 0.193 Q9NUA8 Y595C Polymorphism NA 0.094 0.00 -8 0.077 Q9NUB1 V488M Polymorphism 0.435 0.743 0.04 10 0.379 Q9NUM3 E64D Polymorphism 0.109 0.181 0.56 -22 0.102 Q9NUM3 M221T Polymorphism 0.171 0.320 0.15 -24 0.084 Q9NUM4 T185S Polymorphism NA 0.163 0.76 -11 0.101 Q9NUN5 T144A Polymorphism NA 0.853 0.00 49 0.875 Q9NUP7 A48V Polymorphism 0.303 0.157 0.31 37 0.242 Q9NUQ3 I246V Polymorphism 0.116 0.033 0.30 -46 0.050 Q9NUQ7 N83T Polymorphism NA 0.068 0.22 -39 0.075 Q9NUQ8 P503L Polymorphism 0.314 0.556 0.06 -2 0.580 Q9NUQ8 R510H Polymorphism 0.154 0.218 0.33 -24 0.138 Q9NUR3 L33M Polymorphism NA 0.069 NA 30 0.056 Q9NUT2 V152I Polymorphism 0.076 0.189 0.65 -51 0.163 Q9NUU6 F319L Polymorphism NA 0.239 0.67 16 0.401 Q9NUV7 L140V Polymorphism 0.135 0.132 0.58 -30 0.109 Q9NUW8 A134T Polymorphism 0.175 0.066 0.41 -19 0.068 Q9NUW8 H493R Disease 0.700 0.967 0.00 76 0.942 Q9NUW8 R304Q Polymorphism 0.455 0.262 0.55 3 0.286 Q9NUX5 V529M Polymorphism 0.269 0.115 0.02 38 0.169 Q9NUZ1 P535L Polymorphism 0.694 0.629 0.22 0 0.756 Q9NV06 I42V Polymorphism NA 0.135 0.49 -41 0.125 Q9NV06 N70S Polymorphism 0.147 0.164 0.42 -11 0.132 Q9NV12 P6S Polymorphism NA 0.143 NA 13 0.150 Q9NV58 Q835H Polymorphism NA 0.395 0.00 57 0.531 Q9NV66 D671N Polymorphism 0.132 0.853 0.12 43 0.305 Q9NV92 A136V Polymorphism 0.070 0.153 0.03 -5 0.137 Q9NVC3 L46P Polymorphism 0.603 0.456 0.24 -9 0.517 Q9NVC3 T78I Polymorphism 0.669 0.574 0.17 15 0.314 Q9NVC6 F357L Polymorphism 0.056 0.052 0.26 1 0.053 Q9NVD3 I387V Polymorphism 0.400 0.107 0.47 26 0.127 Q9NVE4 A156T Polymorphism NA 0.062 NA -38 0.047 Q9NVE4 F217L Polymorphism NA 0.078 NA -14 0.033 Q9NVE5 V666A Polymorphism NA 0.147 NA -4 0.135 Q9NVE7 Q684R Polymorphism 0.087 0.024 0.47 -18 0.021 Q9NVH0 Q393H Polymorphism 0.160 0.084 NA -22 0.044 Q9NVH1 T290A Polymorphism 0.129 0.131 0.18 19 0.165 Q9NVI1 P55L Polymorphism NA 0.452 NA 24 0.441 Q9NVI1 C742S Polymorphism 0.162 0.533 NA 33 0.375 Q9NVI7 G15D Polymorphism 0.165 0.174 0.00 29 0.224 Q9NVI7 S101N Polymorphism NA 0.138 0.93 -18 0.118 Q9NVN8 R320H Polymorphism 0.484 0.806 0.02 33 0.738 Q9NVP1 K647R Polymorphism 0.008 0.438 0.57 -11 0.199 Q9NVR7 K149R Polymorphism 0.177 0.029 1.00 -36 0.011 Q9NVS9 R229W Disease 0.984 0.925 0.00 71 0.952 Q9NVU7 A490D Polymorphism NA 0.234 0.63 -18 0.238 Q9NVU7 K258Q Polymorphism 0.470 0.646 0.22 45 0.665 Q9NVV4 S546N Polymorphism 0.071 0.086 0.00 6 0.109 Q9NVV5 Q151E Polymorphism 0.318 0.212 0.85 11 0.259 Q9NVV9 F81L Disease 0.917 0.902 0.02 56 0.866 Q9NVX0 T76P Polymorphism NA 0.538 NA 42 0.736 Q9NVZ3 D149A Polymorphism 0.797 0.818 0.02 39 0.863 Q9NW13 L351P Disease 0.863 0.831 0.00 44 0.883 Q9NW15 R462Q Polymorphism 0.470 0.513 0.22 5 0.454 Q9NW15 V583A Polymorphism 0.342 0.108 0.52 9 0.226 Q9NW38 S144F Polymorphism 0.585 0.182 NA 13 0.345 Q9NW81 R9C Polymorphism 0.714 0.360 0.01 58 0.514 Q9NW97 R92Q Polymorphism NA 0.115 NA 43 0.124 Q9NW97 V34A Polymorphism NA 0.247 NA 39 0.287 Q9NWK9 G9R Polymorphism NA 0.128 0.00 43 0.164 Q9NWM3 R169H Polymorphism 0.425 0.185 NA 27 0.208 Q9NWM3 R316Q Polymorphism 0.530 0.429 NA 61 0.763 Q9NWN3 G704V Polymorphism NA 0.246 NA 44 0.222 Q9NWN3 L533P Polymorphism NA 0.084 NA -27 0.015 Q9NWN3 V432A Polymorphism NA 0.141 0.80 4 0.041 Q9NWQ4 V132E Polymorphism 0.303 0.799 0.00 44 0.750 Q9NWR8 I63N Polymorphism NA 0.357 0.01 -17 0.067 Q9NWR8 I255V Polymorphism 0.076 0.187 0.00 18 0.210 Q9NWR8 Y253F Polymorphism 0.101 0.703 0.00 6 0.346 Q9NWS0 M9L Polymorphism NA 0.029 0.36 -7 0.024 Q9NWS0 G10E Polymorphism NA 0.050 1.00 -2 0.028 Q9NWS0 D230E Polymorphism 0.207 0.069 0.91 -38 0.088 Q9NWS0 P287L Polymorphism 0.433 0.070 0.06 -2 0.052 Q9NWS8 R47H Polymorphism 0.427 0.083 0.05 22 0.030 Q9NWS8 S42I Polymorphism 0.356 0.115 0.03 16 0.034 Q9NWS8 T132M Polymorphism 0.268 0.135 0.01 31 0.150 Q9NWS9 R387H Polymorphism 0.051 0.467 0.00 -23 0.314 Q9NWT8 Q107H Polymorphism NA 0.074 NA 13 0.082 Q9NWW0 P92Q Polymorphism NA 0.123 0.00 6 0.188 Q9NWW5 E72Q Disease 0.375 0.250 NA 3 0.122 Q9NWW5 R62H Disease 0.550 0.554 NA 56 0.771 Q9NWW5 G123D Disease 0.602 0.833 NA 62 0.887 Q9NWW5 M241T Disease 0.430 0.737 NA 38 0.751 Q9NWW5 P159L Disease 0.624 0.401 NA 24 0.551 Q9NWW5 P299L Disease 0.624 0.809 NA 27 0.796 Q9NWW5 W300R Disease 0.667 0.907 NA 34 0.656 Q9NWW5 Y221C Disease 0.791 0.902 NA 57 0.907 Q9NWW5 Y221S Disease 0.559 0.806 NA 44 0.804 Q9NWY4 E331D Polymorphism 0.136 0.084 0.56 -47 0.030 Q9NWZ3 A428T Polymorphism 0.246 0.384 0.59 -41 0.215 Q9NWZ3 M355V Polymorphism 0.208 0.471 0.51 31 0.280 Q9NX00 G120S Polymorphism NA 0.107 NA -46 0.025 Q9NX02 E302Q Polymorphism 0.063 0.606 0.60 -12 0.036 Q9NX02 R364K Polymorphism 0.083 0.691 0.30 12 0.089 Q9NX02 T221M Polymorphism 0.709 0.570 0.22 49 0.767 Q9NX02 A1052E Polymorphism NA 0.162 0.38 6 0.141 Q9NX08 A17P Polymorphism NA 0.081 NA -23 0.021 Q9NX18 G78R Disease 0.960 0.974 0.00 71 0.969 Q9NX20 G29S Polymorphism 0.403 0.656 0.00 19 0.481 Q9NX20 R207C Polymorphism 0.634 0.187 0.01 16 0.385 Q9NX45 S14L Polymorphism NA 0.113 0.21 21 0.039 Q9NX46 E209K Polymorphism 0.312 0.288 0.44 -10 0.281 Q9NX52 L273M Polymorphism 0.455 0.140 0.22 -3 0.253 Q9NX57 N134S Polymorphism NA 0.072 0.93 -3 0.106 Q9NX58 D151Y Polymorphism 0.505 0.175 0.06 17 0.187 Q9NX58 H265R Polymorphism 0.269 0.080 0.68 5 0.052 Q9NX78 A245S Polymorphism NA 0.469 NA 23 0.558 Q9NX94 S302P Polymorphism NA 0.146 0.00 30 0.012 Q9NXA8 E305G Polymorphism NA 0.299 0.01 32 0.447 Q9NXB0 L39F Polymorphism 0.617 0.166 0.00 48 0.253 Q9NXB9 T216A Polymorphism 0.584 0.282 0.30 -26 0.471 Q9NXB9 V225M Polymorphism 0.470 0.465 0.41 -34 0.275 Q9NXD2 R648H Polymorphism 0.147 0.146 0.62 16 0.073 Q9NXF7 N45S Polymorphism NA 0.082 NA 18 0.037 Q9NXF7 T129I Polymorphism NA 0.060 NA 28 0.029 Q9NXF8 V201I Polymorphism 0.789 0.054 0.65 -1 0.111 Q9NXG0 R562C Polymorphism NA 0.189 0.03 51 0.402 Q9NXG0 T284A Polymorphism NA 0.031 0.34 -35 0.019 Q9NXG2 E311D Polymorphism NA 0.076 0.00 -35 0.061 Q9NXJ0 A10D Polymorphism NA 0.201 0.03 20 0.179 Q9NXN4 P95R Polymorphism 0.583 0.679 0.05 26 0.613 Q9NXN4 G106S Polymorphism 0.394 0.739 0.22 10 0.486 Q9NXN4 T489A Polymorphism 0.079 0.132 0.52 10 0.058 Q9NXR8 D20G Disease 0.557 0.512 0.61 32 0.747 Q9NXS2 P214L Polymorphism 0.518 0.178 0.18 -5 0.388 Q9NXW2 E304K Polymorphism 0.511 0.434 0.26 16 0.525 Q9NXZ1 N741K Polymorphism 0.057 0.053 0.15 0 0.067 Q9NY15 G1127R Polymorphism NA 0.185 0.06 49 0.314 Q9NY15 M2506T Polymorphism NA 0.093 0.14 -12 0.027 Q9NY25 R141H Polymorphism 0.504 0.263 0.41 10 0.438 Q9NY27 S282C Polymorphism 0.234 0.097 0.08 14 0.090 Q9NY28 Y53D Polymorphism 0.182 0.143 NA 13 0.008 Q9NY28 Y53N Polymorphism 0.128 0.098 NA -15 0.007 Q9NY28 A337V Polymorphism 0.464 0.473 0.57 7 0.256 Q9NY28 D438G Polymorphism 0.789 0.921 0.00 47 0.764 Q9NY28 V515F Polymorphism 0.448 0.298 0.08 18 0.232 Q9NY33 E690K Polymorphism NA 0.719 0.06 50 0.662 Q9NY33 Q145H Polymorphism 0.319 0.114 0.12 -42 0.232 Q9NY33 R678H Polymorphism NA 0.147 0.57 -47 0.202 Q9NY46 S606T Polymorphism 0.357 0.324 0.04 8 0.394 Q9NY46 D1803N Polymorphism 0.442 0.229 0.06 1 0.332 Q9NY46 L1813S Polymorphism 0.930 0.735 0.00 39 0.871 Q9NY46 V1107A Polymorphism NA 0.162 0.92 4 0.204 Q9NY47 A138V Polymorphism 0.666 0.083 1.00 -15 0.102 Q9NY56 N61K Polymorphism 0.068 0.425 0.74 5 0.210 Q9NY57 R198G Polymorphism NA 0.322 0.44 9 0.349 Q9NY65 A128V Polymorphism NA 0.487 0.02 1 0.536 Q9NY72 S97N Polymorphism 0.686 0.322 0.88 18 0.415 Q9NY74 P715L Polymorphism 0.268 0.174 NA 26 0.167 Q9NY74 S389N Polymorphism 0.271 0.046 NA -18 0.016 Q9NY91 T4M Polymorphism NA 0.176 0.02 40 0.256 Q9NY91 A46T Polymorphism NA 0.545 0.11 -35 0.515 Q9NY99 S168Y Polymorphism 0.676 0.494 0.14 25 0.695 Q9NYB0 K324E Polymorphism 0.268 0.045 1.00 -5 0.037 Q9NYC9 R151H Polymorphism NA 0.144 0.20 -30 0.091 Q9NYC9 D4036N Polymorphism 0.397 0.376 0.07 -14 0.322 Q9NYC9 K2961R Polymorphism 0.112 0.265 0.18 7 0.241 Q9NYC9 K2968N Polymorphism 0.384 0.471 0.41 2 0.384 Q9NYC9 M2087V Polymorphism 0.055 0.529 1.00 -34 0.030 Q9NYC9 M4374I Polymorphism 0.089 0.234 0.29 -32 0.202 Q9NYC9 R1158W Polymorphism NA 0.744 0.01 43 0.823 Q9NYC9 W4462R Polymorphism 0.618 0.311 0.02 39 0.640 Q9NYF0 A464V Polymorphism 0.205 0.055 0.28 9 0.048 Q9NYF0 G697S Polymorphism 0.132 0.097 0.72 2 0.064 Q9NYF0 S628A Polymorphism 0.216 0.077 0.43 11 0.056 Q9NYF3 R21C Polymorphism NA 0.059 0.05 36 0.061 Q9NYF5 M802V Polymorphism 0.087 0.110 0.40 6 0.075 Q9NYF8 L461H Polymorphism 0.753 0.276 0.20 12 0.320 Q9NYF8 N629S Polymorphism 0.349 0.296 0.10 -16 0.255 Q9NYF8 S209C Polymorphism 0.463 0.243 0.05 25 0.146 Q9NYG2 H220Q Polymorphism 0.728 0.307 0.36 13 0.500 Q9NYH9 K35R Polymorphism 0.274 0.177 0.89 -19 0.140 Q9NYH9 L134V Polymorphism 0.569 0.684 0.92 23 0.560 Q9NYI0 P293L Polymorphism NA 0.128 NA 10 0.067 Q9NYI0 T186M Polymorphism NA 0.077 NA 33 0.044 Q9NYI0 T186P Polymorphism NA 0.073 NA 28 0.028 Q9NYJ7 A115T Polymorphism NA 0.341 0.63 -26 0.220 Q9NYJ7 G385D Disease 0.600 0.376 0.05 53 0.597 Q9NYJ7 L142Q Polymorphism NA 0.768 0.00 9 0.694 Q9NYJ7 L218P Polymorphism 0.254 0.442 0.27 21 0.221 Q9NYK1 Q11L Polymorphism NA 0.178 0.29 -33 0.083 Q9NYK1 A448V Polymorphism NA 0.079 0.30 9 0.159 Q9NYK6 D136E Polymorphism NA 0.183 0.00 46 0.252 Q9NYK6 N115K Polymorphism NA 0.062 0.40 12 0.041 Q9NYK6 Y217H Polymorphism NA 0.115 0.43 -23 0.032 Q9NYL2 A281V Polymorphism 0.353 0.576 0.01 23 0.532 Q9NYL2 K784T Polymorphism NA 0.138 NA 45 0.148 Q9NYL2 P740T Polymorphism NA 0.141 NA 30 0.031 Q9NYL5 N324K Polymorphism 0.137 0.169 0.27 -13 0.162 Q9NYL5 R103H Polymorphism 0.087 0.596 0.02 -10 0.164 Q9NYM4 P374Q Polymorphism NA 0.285 0.12 -8 0.281 Q9NYQ3 L221M Polymorphism 0.527 0.543 0.00 35 0.791 Q9NYQ6 S664W Polymorphism 0.740 0.248 0.19 46 0.540 Q9NYQ6 C1126R Polymorphism NA 0.538 0.81 36 0.192 Q9NYQ6 E2903Q Polymorphism NA 0.125 0.18 -22 0.109 Q9NYQ6 G2948S Polymorphism NA 0.159 0.60 -22 0.081 Q9NYQ6 L1995P Polymorphism NA 0.567 0.28 -25 0.370 Q9NYQ6 T2045M Polymorphism NA 0.171 0.22 7 0.251 Q9NYQ6 V1242I Polymorphism NA 0.235 0.25 -13 0.270 Q9NYQ8 F686S Polymorphism NA 0.262 0.62 8 0.282 Q9NYQ8 R574C Polymorphism NA 0.558 0.06 56 0.938 Q9NYQ8 G1004S Polymorphism 0.042 0.399 0.22 10 0.225 Q9NYQ8 G1571S Polymorphism NA 0.689 0.07 17 0.497 Q9NYQ8 M3631I Polymorphism NA 0.251 0.69 -8 0.170 Q9NYQ8 Q3953H Polymorphism 0.723 0.217 0.13 5 0.376 Q9NYQ8 R1895W Polymorphism NA 0.581 0.02 42 0.785 Q9NYQ8 R3318Q Polymorphism NA 0.707 0.44 12 0.306 Q9NYQ8 R3318W Polymorphism NA 0.686 0.02 15 0.654 Q9NYQ8 V1462M Polymorphism NA 0.237 0.14 25 0.380 Q9NYR8 H136Q Polymorphism 0.377 0.454 0.39 17 0.419 Q9NYU1 A821T Polymorphism 0.240 0.182 0.66 15 0.252 Q9NYU1 M994L Polymorphism 0.175 0.256 0.41 19 0.177 Q9NYU1 F1274L Polymorphism 0.776 0.905 0.33 32 0.697 Q9NYV4 P530A Polymorphism NA 0.088 0.00 41 0.169 Q9NYV4 L1189Q Polymorphism NA 0.063 0.22 -24 0.039 Q9NYV4 P1275L Polymorphism NA 0.165 0.05 31 0.033 Q9NYV6 I348M Polymorphism 0.499 0.165 0.17 -24 0.198 Q9NYV7 N172K Polymorphism NA 0.343 1.00 -12 0.242 Q9NYV8 T86A Polymorphism NA 0.275 0.50 -13 0.188 Q9NYV9 N259S Polymorphism NA 0.585 0.45 -18 0.425 Q9NYW1 L238V Polymorphism NA 0.860 0.07 -18 0.598 Q9NYW1 V187A Polymorphism NA 0.417 0.51 -31 0.207 Q9NYW2 M308V Polymorphism NA 0.157 1.00 28 0.041 Q9NYW3 M304I Polymorphism NA 0.156 0.04 22 0.232 Q9NYW4 G20S Polymorphism NA 0.911 0.03 53 0.864 Q9NYW4 P113L Polymorphism NA 0.633 0.45 44 0.564 Q9NYW5 F62L Polymorphism NA 0.284 0.48 -26 0.186 Q9NYW5 T74M Polymorphism NA 0.168 0.25 2 0.231 Q9NYW5 V96L Polymorphism NA 0.200 1.00 -26 0.174 Q9NYW5 I191V Polymorphism NA 0.143 0.89 -23 0.137 Q9NYW5 S171N Polymorphism NA 0.439 0.53 -11 0.285 Q9NYW7 C141Y Polymorphism NA 0.690 0.42 -2 0.485 Q9NYW7 R111H Polymorphism NA 0.297 0.01 27 0.401 Q9NYW7 R206W Polymorphism NA 0.843 0.02 12 0.631 Q9NYY3 P487L Polymorphism 0.414 0.227 0.03 28 0.352 Q9NYZ2 R96Q Polymorphism 0.160 0.551 0.49 10 0.190 Q9NYZ3 A200V Polymorphism 0.285 0.047 0.27 9 0.037 Q9NYZ3 A274T Polymorphism 0.300 0.058 0.53 19 0.052 Q9NYZ3 A635T Polymorphism 0.123 0.022 0.11 -26 0.032 Q9NYZ3 D463E Polymorphism 0.140 0.043 0.79 13 0.046 Q9NYZ3 S322N Polymorphism 0.222 0.095 0.49 6 0.068 Q9NYZ3 T181A Polymorphism 0.078 0.034 0.76 -17 0.029 Q9NYZ4 R388G Polymorphism 0.595 0.557 0.02 58 0.788 Q9NZ08 Q730E Polymorphism 0.091 0.393 0.37 15 0.150 Q9NZ20 E116Q Polymorphism NA 0.146 NA -1 0.138 Q9NZ20 H307Y Polymorphism 0.285 0.112 NA 34 0.115 Q9NZ20 L157V Polymorphism 0.235 0.590 0.02 12 0.531 Q9NZ53 V456A Polymorphism 0.317 0.179 0.21 12 0.199 Q9NZ56 R1291G Polymorphism 0.250 0.459 0.03 14 0.439 Q9NZ56 R1468H Polymorphism 0.094 0.215 0.04 -6 0.204 Q9NZ71 N124S Polymorphism 0.144 0.144 0.67 -29 0.102 Q9NZ94 R451C Disease 0.862 0.617 0.13 14 0.755 Q9NZA1 T114A Polymorphism NA 0.067 0.36 5 0.032 Q9NZB2 Y327H Polymorphism 0.589 0.645 0.12 26 0.791 Q9NZB8 C80G Disease NA 0.889 0.00 71 0.914 Q9NZB8 C84F Disease NA 0.881 0.00 77 0.914 Q9NZB8 R67W Disease NA 0.899 0.00 69 0.915 Q9NZB8 R73W Disease NA 0.913 0.00 63 0.921 Q9NZB8 G126D Disease NA 0.869 0.00 78 0.911 Q9NZB8 G127D Disease NA 0.894 0.00 81 0.901 Q9NZB8 G324E Disease 0.910 0.909 0.00 75 0.933 Q9NZB8 G324R Disease 0.925 0.859 0.00 77 0.925 Q9NZB8 R123W Disease NA 0.943 0.00 62 0.924 Q9NZB8 R319Q Disease 0.842 0.927 0.00 58 0.937 Q9NZC2 D134G Disease NA 0.587 0.32 22 0.355 Q9NZC2 H157Y Polymorphism NA 0.219 0.52 45 0.236 Q9NZC2 K186N Disease NA 0.492 0.12 32 0.633 Q9NZC2 L211P Polymorphism NA 0.138 NA 31 0.036 Q9NZC3 E328K Polymorphism NA 0.115 0.60 12 0.107 Q9NZC3 R218Q Polymorphism 0.523 0.488 0.64 -21 0.469 Q9NZC7 P98L Polymorphism 0.262 0.561 0.08 18 0.598 Q9NZC7 A179T Polymorphism 0.137 0.266 0.54 -11 0.157 Q9NZC7 L216V Polymorphism 0.206 0.257 0.29 11 0.181 Q9NZC7 L272F Polymorphism NA 0.453 0.16 -14 0.317 Q9NZC7 P282A Polymorphism NA 0.192 0.41 19 0.305 Q9NZC9 A468P Disease 0.760 0.933 0.01 58 0.929 Q9NZC9 I548N Disease 0.492 0.589 0.00 52 0.736 Q9NZC9 K647Q Disease 0.432 0.874 0.04 58 0.862 Q9NZC9 K647T Disease 0.650 0.904 0.00 58 0.915 Q9NZC9 R114H Polymorphism NA 0.059 NA 23 0.061 Q9NZC9 R586W Disease 0.895 0.834 0.01 62 0.922 Q9NZC9 R644W Disease 0.953 0.929 0.00 62 0.924 Q9NZC9 R645C Disease 0.937 0.898 0.00 64 0.923 Q9NZC9 R764Q Disease 0.746 0.844 0.02 66 0.915 Q9NZC9 R820H Disease 0.855 0.936 0.00 77 0.923 Q9NZC9 S315R Polymorphism NA 0.055 NA 39 0.093 Q9NZC9 S579L Disease 0.580 0.784 0.00 55 0.867 Q9NZC9 T705I Disease 0.565 0.368 0.27 40 0.638 Q9NZE8 R29H Polymorphism 0.414 0.219 0.00 43 0.238 Q9NZE8 Y180C Polymorphism 0.896 0.901 0.00 69 0.960 Q9NZH6 G31V Polymorphism 0.575 0.104 0.09 -14 0.144 Q9NZH6 N54S Polymorphism 0.056 0.046 1.00 -27 0.028 Q9NZH6 P50R Polymorphism 0.064 0.224 0.08 38 0.210 Q9NZH7 R36C Polymorphism 0.752 0.054 0.06 31 0.071 Q9NZH8 Q69K Polymorphism 0.292 0.135 0.97 -16 0.069 Q9NZI7 T212A Polymorphism 0.245 0.947 0.00 54 0.899 Q9NZJ0 A436V Polymorphism 0.199 0.039 0.56 -8 0.058 Q9NZJ4 A694T Polymorphism NA 0.095 NA -3 0.067 Q9NZJ4 N232K Polymorphism NA 0.459 NA 27 0.369 Q9NZJ4 K2017N Polymorphism NA 0.120 NA 45 0.133 Q9NZJ4 K2958R Polymorphism NA 0.072 NA 11 0.113 Q9NZK5 H335R Polymorphism 0.086 0.109 0.35 4 0.095 Q9NZL3 H506D Polymorphism 0.467 0.465 0.00 81 0.828 Q9NZL9 A293T Polymorphism 0.404 0.618 0.15 -10 0.426 Q9NZM1 R1399C Polymorphism 0.578 0.592 0.06 54 0.818 Q9NZM1 V1136I Polymorphism 0.292 0.126 0.18 16 0.255 Q9NZM1 Y1198F Polymorphism 0.073 0.345 0.59 20 0.199 Q9NZN5 Y973F Polymorphism 0.499 0.352 0.62 -2 0.406 Q9NZN8 A460T Polymorphism 0.631 0.872 0.14 8 0.636 Q9NZN9 D90H Polymorphism 0.312 0.859 0.03 34 0.629 Q9NZN9 V33A Polymorphism 0.179 0.252 0.20 4 0.172 Q9NZN9 C239R Disease 0.924 0.955 0.00 67 0.955 Q9NZN9 Y134F Polymorphism 0.436 0.415 1.00 35 0.300 Q9NZP0 S69L Polymorphism 0.094 0.647 0.79 -7 0.112 Q9NZP6 A757T Polymorphism NA 0.026 0.11 0 0.029 Q9NZP6 G253R Polymorphism NA 0.119 0.12 10 0.048 Q9NZP6 P343A Polymorphism NA 0.160 1.00 19 0.111 Q9NZP6 T929P Polymorphism NA 0.055 0.34 30 0.022 Q9NZP6 V212A Polymorphism NA 0.192 0.09 28 0.181 Q9NZQ3 T324S Polymorphism 0.156 0.871 NA 41 0.515 Q9NZQ8 V254A Polymorphism 0.653 0.404 0.27 -9 0.581 Q9NZQ8 V335L Polymorphism 0.382 0.110 1.00 -44 0.102 Q9NZR1 P63A Polymorphism 0.410 0.359 0.14 1 0.415 Q9NZR2 Q48R Polymorphism NA 0.142 0.63 39 0.159 Q9NZR2 V4264L Polymorphism NA 0.217 0.17 32 0.233 Q9NZR4 D144E Disease 0.056 0.446 0.83 -6 0.212 Q9NZR4 G160D Disease NA 0.433 0.59 8 0.399 Q9NZR4 H244R Disease 0.653 0.781 0.15 48 0.786 Q9NZR4 L159M Disease NA 0.279 0.24 -27 0.293 Q9NZR4 R166W Disease 0.831 0.906 0.00 64 0.937 Q9NZS2 L67F Polymorphism 0.155 0.089 0.70 48 0.137 Q9NZS9 R245H Polymorphism 0.595 0.132 0.00 27 0.205 Q9NZT1 K74R Polymorphism 0.127 0.164 0.09 -7 0.128 Q9NZT2 R545S Polymorphism 0.169 0.087 0.53 22 0.024 Q9NZU0 E460D Polymorphism 0.093 0.096 0.74 -13 0.059 Q9NZV1 E502K Polymorphism 0.343 0.206 0.59 17 0.254 Q9NZV7 A110T Polymorphism NA 0.065 0.14 -62 0.015 Q9NZV7 Q408R Polymorphism 0.271 0.206 0.03 20 0.221 Q9NZV7 R473K Polymorphism 0.206 0.360 1.00 37 0.140 Q9NZW4 Y6D Disease NA 0.797 0.00 39 0.745 Q9NZW4 P17T Disease NA 0.500 0.00 41 0.709 Q9NZW4 R68W Polymorphism NA 0.596 0.00 28 0.693 Q9NZW4 V18F Disease NA 0.491 0.00 57 0.638 Q9NZW4 D243N Polymorphism NA 0.172 0.02 -22 0.047 Q9P003 A3G Polymorphism NA 0.633 0.00 -5 0.500 Q9P035 E56K Polymorphism 0.104 0.266 0.17 16 0.202 Q9P0G3 H45Y Polymorphism 0.121 0.274 1.00 -21 0.159 Q9P0G3 R64H Polymorphism 0.084 0.588 0.20 -1 0.018 Q9P0K1 H119Y Polymorphism 0.179 0.756 0.97 22 0.410 Q9P0K1 V207I Polymorphism 0.117 0.173 0.19 -52 0.146 Q9P0K7 A44T Polymorphism 0.633 0.207 0.17 26 0.501 Q9P0K7 A870S Polymorphism NA 0.136 0.57 -29 0.056 Q9P0K7 V499L Polymorphism 0.063 0.294 0.00 15 0.208 Q9P0K8 P229R Polymorphism NA 0.265 0.28 7 0.242 Q9P0K8 P310S Polymorphism NA 0.180 0.90 -19 0.028 Q9P0L0 M8T Polymorphism NA 0.655 0.00 52 0.663 Q9P0L0 P104L Polymorphism 0.690 0.215 0.42 0 0.474 Q9P0L1 R24C Polymorphism NA 0.128 0.10 -11 0.098 Q9P0L1 E359K Polymorphism 0.394 0.797 0.24 16 0.448 Q9P0L1 F153S Polymorphism NA 0.232 0.45 5 0.143 Q9P0L2 E691G Polymorphism NA 0.284 0.00 35 0.362 Q9P0L2 P578L Polymorphism NA 0.154 0.31 33 0.252 Q9P0L2 R645G Polymorphism NA 0.566 0.00 38 0.521 Q9P0L9 V393I Polymorphism 0.160 0.139 1.00 -45 0.103 Q9P0M9 T24A Polymorphism NA 0.102 0.01 -21 0.102 Q9P0P0 Y118H Polymorphism 0.430 0.348 0.56 -13 0.287 Q9P0S9 F108L Polymorphism 0.658 0.052 0.65 -29 0.027 Q9P0S9 H112D Polymorphism NA 0.262 0.00 29 0.204 Q9P0V8 P5T Polymorphism 0.125 0.094 0.60 -28 0.042 Q9P0W0 I97N Polymorphism 0.706 0.619 0.00 44 0.800 Q9P0W5 A481V Polymorphism 0.118 0.101 NA 7 0.068 Q9P0W5 E101K Polymorphism 0.326 0.080 NA 25 0.058 Q9P0W8 D2N Polymorphism NA 0.160 NA 34 0.157 Q9P0W8 V74M Polymorphism NA 0.082 NA -28 0.066 Q9P0W8 G324E Polymorphism NA 0.368 NA 42 0.226 Q9P0W8 S165N Polymorphism NA 0.033 NA 8 0.066 Q9P0X4 G1782R Polymorphism 0.624 0.198 0.19 36 0.222 Q9P0X4 I1040V Polymorphism NA 0.155 0.51 -12 0.068 Q9P0X4 T1513M Polymorphism 0.484 0.213 0.22 38 0.312 Q9P107 D641N Polymorphism 0.369 0.255 0.56 -47 0.273 Q9P109 V321I Polymorphism 0.122 0.174 0.42 7 0.131 Q9P126 G64D Polymorphism 0.261 0.126 0.28 2 0.193 Q9P126 I20V Polymorphism 0.128 0.070 0.58 17 0.086 Q9P126 S24P Polymorphism 0.107 0.234 0.26 -21 0.175 Q9P126 S28F Polymorphism 0.299 0.529 0.03 34 0.691 Q9P127 P14S Polymorphism NA 0.196 0.00 17 0.086 Q9P1A6 P419Q Polymorphism 0.948 0.483 0.18 32 0.709 Q9P1Q5 R128H Polymorphism 0.180 0.222 1.00 0 0.151 Q9P1Q5 V233M Polymorphism 0.199 0.661 0.03 0 0.350 Q9P1U0 Q14H Polymorphism 0.269 0.081 0.00 23 0.123 Q9P1U1 R250Q Polymorphism 0.091 0.518 0.06 7 0.054 Q9P1V8 K454E Polymorphism NA 0.127 0.75 21 0.045 Q9P1W3 M654V Polymorphism 0.127 0.065 0.51 0 0.085 Q9P1W9 G138D Polymorphism 0.464 0.419 0.84 -47 0.178 Q9P1W9 I280V Polymorphism 0.168 0.159 0.41 -4 0.187 Q9P1Y5 P335S Polymorphism 0.211 0.286 0.12 -41 0.255 Q9P1Z0 A539V Polymorphism NA 0.116 0.18 28 0.101 Q9P1Z0 M550I Polymorphism NA 0.075 0.24 19 0.059 Q9P1Z0 N561S Polymorphism NA 0.086 0.45 23 0.078 Q9P1Z3 P630L Polymorphism 0.142 0.116 0.01 -8 0.140 Q9P1Z9 E917K Polymorphism 0.350 0.161 0.22 10 0.071 Q9P1Z9 D1518N Polymorphism NA 0.599 NA 56 0.719 Q9P1Z9 F1146L Polymorphism 0.054 0.302 NA 9 0.150 Q9P202 A440T Polymorphism 0.344 0.265 1.00 -41 0.199 Q9P202 M613T Polymorphism 0.110 0.118 0.12 -13 0.035 Q9P206 L310I Polymorphism NA 0.108 0.66 -36 0.038 Q9P206 P770L Polymorphism NA 0.057 0.02 30 0.069 Q9P209 P412T Polymorphism 0.297 0.111 0.04 16 0.155 Q9P209 T509A Polymorphism 0.185 0.074 0.03 -3 0.048 Q9P212 H1927R Polymorphism 0.249 0.349 1.00 29 0.068 Q9P212 S1484L Disease 0.699 0.739 0.00 38 0.845 Q9P218 P134L Polymorphism NA 0.076 0.08 -2 0.092 Q9P219 A811E Polymorphism NA 0.188 0.87 28 0.126 Q9P219 L637V Polymorphism NA 0.247 0.51 14 0.320 Q9P219 A1028V Polymorphism NA 0.066 0.35 6 0.038 Q9P225 S312T Polymorphism NA 0.892 0.55 15 0.598 Q9P225 E1326G Polymorphism NA 0.223 0.39 9 0.330 Q9P225 R2548H Polymorphism 0.525 0.290 0.59 -13 0.341 Q9P241 T43I Polymorphism 0.434 0.166 0.20 26 0.308 Q9P241 A337T Polymorphism 0.696 0.618 0.04 14 0.746 Q9P241 C171R Polymorphism 0.113 0.366 0.39 39 0.183 Q9P241 F522L Polymorphism NA 0.138 0.70 21 0.190 Q9P241 S959N Polymorphism 0.204 0.223 0.47 -41 0.181 Q9P241 R1183K Polymorphism 0.173 0.169 1.00 -47 0.102 Q9P241 V1240I Polymorphism NA 0.273 0.34 -54 0.271 Q9P243 G64R Polymorphism NA 0.251 0.00 36 0.266 Q9P243 P102S Polymorphism NA 0.090 1.00 -24 0.077 Q9P243 R672K Polymorphism NA 0.061 0.73 27 0.087 Q9P255 T106K Polymorphism 0.447 0.627 0.59 25 0.502 Q9P266 E729A Polymorphism NA 0.061 0.25 16 0.072 Q9P273 S385C Polymorphism 0.226 0.287 0.01 39 0.344 Q9P275 K814N Polymorphism NA 0.097 0.00 36 0.151 Q9P275 Q806R Polymorphism NA 0.045 0.29 -10 0.031 Q9P275 R828C Polymorphism NA 0.054 0.00 48 0.020 Q9P275 R887P Polymorphism NA 0.083 NA 36 0.081 Q9P278 T298S Polymorphism NA 0.066 1.00 -24 0.058 Q9P283 I220T Polymorphism 0.164 0.431 0.64 -30 0.160 Q9P283 V840D Polymorphism 0.373 0.376 0.04 -22 0.216 Q9P283 D1028G Polymorphism NA 0.627 0.74 32 0.409 Q9P286 A555S Polymorphism 0.553 0.509 0.02 30 0.589 Q9P286 P187A Polymorphism NA 0.165 0.28 33 0.150 Q9P286 R335P Polymorphism NA 0.179 0.41 28 0.103 Q9P286 S511N Polymorphism 0.139 0.338 0.29 1 0.104 Q9P287 E254Q Polymorphism 0.398 0.766 0.18 26 0.602 Q9P289 Q9R Polymorphism NA 0.196 0.30 19 0.165 Q9P298 S86N Polymorphism 0.189 0.130 0.27 -33 0.054 Q9P2B2 S277T Polymorphism 0.077 0.238 1.00 0 0.181 Q9P2B2 V837I Polymorphism 0.158 0.108 0.00 -12 0.106 Q9P2B4 S409G Polymorphism NA 0.157 0.50 2 0.109 Q9P2B4 V296M Polymorphism NA 0.081 0.11 12 0.093 Q9P2D0 A1185V Polymorphism 0.193 0.029 0.13 17 0.067 Q9P2D0 V1065I Polymorphism 0.345 0.097 0.46 12 0.075 Q9P2D1 H55R Disease NA 0.109 0.02 39 0.141 Q9P2D1 S834F Disease 0.705 0.954 0.01 58 0.935 Q9P2D1 A2789T Disease 0.254 0.153 0.00 22 0.246 Q9P2D1 F2750L Polymorphism 0.171 0.148 0.56 -12 0.072 Q9P2D1 H2096R Disease 0.221 0.697 0.00 24 0.674 Q9P2D1 I1028V Disease 0.443 0.082 0.10 30 0.243 Q9P2D1 K2948E Disease NA 0.067 0.00 28 0.047 Q9P2D1 L1257R Disease 0.982 0.913 0.00 59 0.943 Q9P2D1 L1294P Disease 0.985 0.911 0.00 57 0.943 Q9P2D1 L1815P Disease NA 0.961 0.00 46 0.868 Q9P2D1 P2880L Disease 0.551 0.111 0.09 21 0.159 Q9P2D1 Q1214R Disease 0.969 0.888 0.00 56 0.941 Q9P2D1 R2319S Disease 0.658 0.793 0.01 46 0.853 Q9P2D1 W1031G Disease 0.999 0.831 0.00 60 0.943 Q9P2D6 I725V Polymorphism NA 0.021 0.00 -26 0.071 Q9P2D7 E205D Polymorphism NA 0.175 NA -33 0.132 Q9P2D7 V441L Polymorphism NA 0.341 0.58 -1 0.220 Q9P2D7 R1663C Polymorphism 0.902 0.719 0.06 47 0.868 Q9P2D8 V1597A Polymorphism NA 0.081 NA -48 0.022 Q9P2E2 I341V Polymorphism 0.116 0.035 0.65 22 0.189 Q9P2E3 Q924H Polymorphism NA 0.135 0.05 -40 0.209 Q9P2E3 G1297S Polymorphism 0.092 0.182 0.05 -17 0.112 Q9P2F6 A522T Polymorphism 0.345 0.061 0.03 20 0.176 Q9P2F8 T49A Polymorphism NA 0.078 0.25 -38 0.029 Q9P2F8 G1639S Polymorphism 0.170 0.080 0.49 -12 0.059 Q9P2F8 S1403L Polymorphism 0.222 0.132 0.02 23 0.252 Q9P2F8 T1322A Polymorphism 0.267 0.059 1.00 -5 0.025 Q9P2G1 L1016M Polymorphism NA 0.215 NA 4 0.117 Q9P2H0 A178T Polymorphism NA 0.026 NA -35 0.062 Q9P2H0 A302T Polymorphism NA 0.022 NA -25 0.029 Q9P2H0 I281T Polymorphism NA 0.097 NA 16 0.060 Q9P2H0 S275Y Polymorphism NA 0.107 NA 33 0.103 Q9P2H0 M1021T Polymorphism NA 0.253 NA 31 0.158 Q9P2H3 A701P Disease NA 0.785 0.00 62 0.863 Q9P2H3 H105Q Disease 0.689 0.865 0.00 75 0.905 Q9P2H3 T586S Polymorphism 0.044 0.027 0.79 -39 0.017 Q9P2J2 R474P Polymorphism 0.256 0.333 0.15 36 0.312 Q9P2J2 P1117T Polymorphism NA 0.085 0.00 17 0.185 Q9P2J2 S1026T Polymorphism NA 0.139 0.00 3 0.338 Q9P2J8 K135N Polymorphism 0.337 0.272 0.46 25 0.342 Q9P2K1 E376A Polymorphism 0.211 0.081 0.06 21 0.079 Q9P2K1 V660I Polymorphism 0.503 0.038 0.00 -44 0.060 Q9P2K1 L1551P Disease NA 0.719 0.02 36 0.741 Q9P2K1 P1122S Disease NA 0.635 0.00 46 0.722 Q9P2K1 Q1096H Disease 0.510 0.493 0.00 0 0.442 Q9P2K1 R1528C Disease NA 0.763 0.01 48 0.748 Q9P2K3 K42R Polymorphism 0.270 0.652 0.10 27 0.512 Q9P2K5 S465G Polymorphism 0.086 0.187 0.37 -19 0.088 Q9P2K8 K1336R Polymorphism 0.404 0.660 0.01 -21 0.519 Q9P2K8 Q1406H Polymorphism 0.387 0.164 0.15 24 0.325 Q9P2K8 T1060R Polymorphism 0.295 0.500 0.05 7 0.433 Q9P2K9 G182S Polymorphism NA 0.034 0.02 21 0.051 Q9P2K9 G661A Polymorphism NA 0.143 0.08 6 0.140 Q9P2L0 E983G Polymorphism 0.403 0.097 0.01 10 0.205 Q9P2M4 E446Q Polymorphism NA 0.514 0.26 -10 0.442 Q9P2N2 I168V Polymorphism NA 0.119 1.00 -22 0.078 Q9P2N2 T190S Polymorphism NA 0.085 0.73 -4 0.093 Q9P2N4 S96P Polymorphism NA 0.549 0.32 -82 0.409 Q9P2N4 D1674E Polymorphism 0.095 0.159 0.92 4 0.120 Q9P2N4 E1791Q Polymorphism 0.352 0.293 0.00 47 0.432 Q9P2N4 K1921E Polymorphism NA 0.312 0.00 42 0.537 Q9P2N6 V707I Polymorphism 0.270 0.116 0.42 16 0.053 Q9P2P1 E997K Polymorphism 0.377 0.142 0.80 44 0.089 Q9P2P1 T457M Polymorphism NA 0.070 0.10 37 0.030 Q9P2P1 I1551V Polymorphism NA 0.062 0.40 12 0.114 Q9P2R7 V13M Polymorphism NA 0.143 0.03 22 0.153 Q9P2R7 G118R Disease 0.947 0.949 0.00 68 0.947 Q9P2R7 R284C Disease 0.972 0.913 0.00 71 0.946 Q9P2S2 L81Q Polymorphism NA 0.334 0.61 34 0.487 Q9P2S5 I331M Polymorphism 0.109 0.208 0.09 -25 0.181 Q9P2S5 V358I Polymorphism 0.132 0.056 0.36 -45 0.274 Q9P2S6 I424M Polymorphism 0.152 0.118 0.01 32 0.074 Q9P2S6 T649M Polymorphism 0.557 0.065 0.03 10 0.133 Q9P2T0 H297Y Polymorphism NA 0.023 1.00 -24 0.020 Q9P2T1 G242D Polymorphism 0.982 0.950 0.00 71 0.946 Q9P2U7 P431R Polymorphism 0.527 0.942 0.02 53 0.861 Q9P2U8 N551S Polymorphism NA 0.116 0.80 -5 0.092 Q9P2V4 L154M Polymorphism 0.424 0.779 0.04 10 0.443 Q9P2V4 P389T Polymorphism NA 0.072 0.23 15 0.082 Q9P2V4 S591G Polymorphism NA 0.078 0.52 19 0.083 Q9P2W7 A131T Polymorphism NA 0.375 0.27 -37 0.260 Q9P2W9 D32Y Polymorphism 0.648 0.500 0.02 38 0.640 Q9P2W9 S51G Polymorphism 0.271 0.096 0.51 -29 0.159 Q9TNN7 A73E Polymorphism 0.554 0.588 0.07 20 0.615 Q9TNN7 K90N Polymorphism 0.213 0.276 0.47 -28 0.199 Q9TNN7 V76M Polymorphism 0.313 0.163 0.50 -42 0.169 Q9TNN7 A223V Polymorphism 0.313 0.246 0.56 -10 0.326 Q9TNN7 N138D Polymorphism 0.304 0.287 0.23 -26 0.219 Q9TNN7 V272M Polymorphism 0.800 0.426 0.05 6 0.577 Q9UBB9 N177S Polymorphism 0.236 0.204 0.57 13 0.301 Q9UBC1 C224R Polymorphism 0.090 0.054 NA 37 0.043 Q9UBC3 R54P Polymorphism 0.413 0.471 0.00 37 0.469 Q9UBC3 A585V Disease 0.643 0.750 0.04 57 0.888 Q9UBC3 A603T Disease 0.629 0.902 0.05 36 0.831 Q9UBC3 A766P Disease 0.767 0.893 0.02 39 0.835 Q9UBC3 D817G Disease 0.591 0.961 0.00 48 0.849 Q9UBC3 G663S Disease 0.309 0.943 0.12 23 0.572 Q9UBC3 H814R Disease 0.500 0.937 0.01 42 0.756 Q9UBC3 L664P Disease 0.867 0.987 0.01 26 0.801 Q9UBC3 R840Q Disease 0.589 0.807 0.00 39 0.797 Q9UBC3 S270P Disease 0.709 0.919 0.00 44 0.847 Q9UBC3 V606A Disease 0.573 0.528 0.05 33 0.724 Q9UBC3 V699G Disease 0.694 0.920 0.05 56 0.921 Q9UBC3 V726G Disease 0.289 0.923 0.32 49 0.555 Q9UBC3 V818M Disease 0.732 0.760 0.00 50 0.883 Q9UBC5 C506S Polymorphism 0.381 0.168 0.82 10 0.152 Q9UBC5 E385D Disease 0.997 0.913 0.00 49 0.928 Q9UBC5 G662E Disease 0.362 0.569 1.00 -33 0.258 Q9UBC5 G674D Disease 0.999 0.925 0.00 56 0.952 Q9UBC5 P426L Polymorphism 0.448 0.324 0.05 -16 0.474 Q9UBC5 S797F Disease 0.580 0.353 0.04 -36 0.587 Q9UBC5 S910P Disease 0.322 0.460 0.24 8 0.508 Q9UBC5 T996I Polymorphism NA 0.070 0.23 -15 0.076 Q9UBC5 V306M Disease 0.349 0.506 0.09 -52 0.328 Q9UBD3 H28D Polymorphism 0.087 0.153 0.65 25 0.033 Q9UBD3 R29K Polymorphism 0.092 0.044 0.92 -3 0.042 Q9UBD5 Q126R Polymorphism 0.219 0.595 0.20 -4 0.366 Q9UBD5 R588C Polymorphism 0.948 0.827 0.02 62 0.939 Q9UBD5 T287M Polymorphism 0.526 0.208 0.11 -4 0.440 Q9UBD5 T389P Polymorphism 0.648 0.680 0.04 28 0.728 Q9UBD5 V217I Polymorphism 0.239 0.093 0.13 -37 0.169 Q9UBD9 R197L Disease 0.877 0.450 0.00 36 0.617 Q9UBF2 I547L Polymorphism 0.361 0.399 0.94 -28 0.241 Q9UBF9 S39F Disease NA 0.226 NA 47 0.199 Q9UBF9 S55F Disease NA 0.091 NA 46 0.077 Q9UBF9 S60C Disease NA 0.134 NA 33 0.110 Q9UBF9 S60F Disease NA 0.141 NA 49 0.146 Q9UBF9 S95I Disease NA 0.124 NA 33 0.107 Q9UBF9 T57I Disease NA 0.120 NA 34 0.076 Q9UBG3 A27V Polymorphism 0.593 0.097 0.27 -31 0.123 Q9UBG3 G480S Polymorphism NA 0.284 NA 6 0.152 Q9UBG3 Q374H Polymorphism NA 0.061 0.02 47 0.100 Q9UBH0 N47S Polymorphism 0.442 0.199 1.00 18 0.308 Q9UBK2 G482S Polymorphism NA 0.022 1.00 -35 0.024 Q9UBK8 I49M Polymorphism NA 0.403 0.03 28 0.453 Q9UBK8 V83M Disease 0.604 0.279 0.05 51 0.663 Q9UBK8 A156T Disease 0.468 0.338 0.03 41 0.507 Q9UBK8 A542V Polymorphism 0.220 0.211 0.36 -6 0.240 Q9UBK8 C432R Disease 0.778 0.553 0.03 41 0.731 Q9UBK8 G514R Disease 0.974 0.898 0.00 77 0.896 Q9UBK8 G581R Disease 0.505 0.930 0.01 53 0.904 Q9UBK8 H622Y Polymorphism 0.300 0.368 0.05 1 0.364 Q9UBK8 K377R Polymorphism 0.217 0.098 0.56 40 0.154 Q9UBK8 L360V Polymorphism 0.102 0.296 0.77 -24 0.225 Q9UBK8 P477R Polymorphism 0.754 0.730 0.01 60 0.711 Q9UBK8 S284T Polymorphism NA 0.362 0.77 -34 0.244 Q9UBL6 F77L Polymorphism 0.257 0.770 0.04 48 0.569 Q9UBL6 P633L Polymorphism NA 0.320 0.00 2 0.504 Q9UBM1 R3W Polymorphism 0.182 0.063 0.29 -37 0.035 Q9UBM1 V58I Polymorphism 0.094 0.161 0.62 -30 0.100 Q9UBM1 V58L Polymorphism 0.167 0.244 0.53 -33 0.188 Q9UBM4 R229C Polymorphism 0.786 0.561 0.19 13 0.660 Q9UBM4 R325W Polymorphism 0.914 0.334 0.00 52 0.607 Q9UBM7 L68P Disease 0.673 0.834 0.08 0 0.718 Q9UBM7 L99P Disease 0.545 0.782 0.05 20 0.814 Q9UBM7 P51S Disease 0.439 0.920 0.00 -6 0.762 Q9UBM7 T93M Disease 0.429 0.159 0.09 27 0.299 Q9UBM7 A247V Disease 0.414 0.439 0.08 7 0.412 Q9UBM7 C183Y Disease 0.653 0.723 0.01 0 0.808 Q9UBM7 C311G Disease 0.452 0.841 0.01 15 0.811 Q9UBM7 C311Y Disease 0.471 0.741 0.03 -10 0.553 Q9UBM7 C380R Disease 0.490 0.631 0.05 53 0.743 Q9UBM7 C380S Disease 0.208 0.461 0.17 24 0.358 Q9UBM7 C380Y Disease 0.599 0.537 0.04 52 0.585 Q9UBM7 E448K Disease 0.288 0.843 0.03 51 0.861 Q9UBM7 E448Q Disease 0.306 0.694 0.04 23 0.549 Q9UBM7 F235S Disease 0.483 0.668 0.01 28 0.786 Q9UBM7 F255L Disease 0.282 0.357 0.57 0 0.285 Q9UBM7 G138V Disease 0.591 0.932 0.01 60 0.917 Q9UBM7 G147D Disease 0.710 0.937 0.01 70 0.941 Q9UBM7 G244R Disease 0.774 0.932 0.00 68 0.944 Q9UBM7 G344R Disease 0.737 0.819 0.65 30 0.770 Q9UBM7 G410R Disease 0.492 0.953 0.01 60 0.923 Q9UBM7 G410S Disease 0.273 0.837 0.06 47 0.697 Q9UBM7 H119L Disease 0.103 0.226 0.04 -13 0.243 Q9UBM7 H405Y Disease 0.534 0.962 0.00 66 0.936 Q9UBM7 H426P Disease 0.430 0.938 0.12 58 0.917 Q9UBM7 I145L Disease 0.123 0.440 0.96 0 0.223 Q9UBM7 I297T Disease 0.898 0.910 0.00 47 0.899 Q9UBM7 K198E Disease 0.473 0.726 0.04 54 0.850 Q9UBM7 L109P Disease 0.521 0.918 0.02 39 0.854 Q9UBM7 L157P Disease 0.611 0.734 0.05 20 0.808 Q9UBM7 Q107H Disease 0.439 0.685 0.12 36 0.577 Q9UBM7 R242C Disease 0.987 0.939 0.00 71 0.957 Q9UBM7 R242H Disease 0.973 0.869 0.00 75 0.945 Q9UBM7 R352Q Disease 0.276 0.867 0.04 59 0.885 Q9UBM7 R352W Disease 0.640 0.920 0.00 55 0.920 Q9UBM7 R362C Disease 0.840 0.965 0.00 63 0.943 Q9UBM7 R404C Disease 0.840 0.962 0.00 76 0.943 Q9UBM7 R404S Disease 0.543 0.933 0.00 69 0.935 Q9UBM7 R443C Disease 0.990 0.959 0.00 71 0.957 Q9UBM7 R446Q Disease 0.960 0.936 0.00 56 0.955 Q9UBM7 R450L Disease 0.584 0.812 0.05 26 0.718 Q9UBM7 S113C Disease 0.105 0.202 0.21 -4 0.123 Q9UBM7 S169L Disease 0.451 0.654 0.30 -12 0.417 Q9UBM7 S397L Disease 0.564 0.875 0.00 40 0.868 Q9UBM7 T154M Disease 0.737 0.745 0.00 28 0.817 Q9UBM7 T289I Disease 0.353 0.412 0.17 -4 0.490 Q9UBM7 V281M Disease 0.588 0.869 0.01 13 0.844 Q9UBM7 V326L Disease 0.309 0.561 0.27 -35 0.384 Q9UBM7 V353A Disease 0.124 0.196 0.59 -26 0.097 Q9UBM7 W182C Disease 0.609 0.531 0.18 -7 0.714 Q9UBM7 W182L Disease 0.283 0.485 0.85 -14 0.247 Q9UBM7 W248C Disease 0.984 0.896 0.00 58 0.949 Q9UBM7 Y324H Disease 0.632 0.875 0.00 69 0.915 Q9UBM7 Y408H Disease 0.959 0.936 0.00 80 0.955 Q9UBN7 T994I Polymorphism 0.053 0.170 0.01 24 0.170 Q9UBP0 S44L Polymorphism NA 0.321 NA 23 0.219 Q9UBP0 A485V Disease 0.985 0.785 0.00 59 0.917 Q9UBP0 A551Y Disease 0.772 0.352 0.08 25 0.634 Q9UBP0 A556V Disease 0.981 0.831 0.04 37 0.852 Q9UBP0 C448Y Disease 0.486 0.396 0.04 40 0.547 Q9UBP0 D441G Disease 0.885 0.874 0.00 64 0.891 Q9UBP0 D470V Disease 0.781 0.888 0.00 60 0.869 Q9UBP0 D493G Disease 0.987 0.910 0.00 65 0.921 Q9UBP0 D555N Disease 0.550 0.608 0.03 29 0.558 Q9UBP0 D584H Disease 0.770 0.806 0.31 55 0.772 Q9UBP0 E512D Disease 0.156 0.295 0.21 -20 0.223 Q9UBP0 F381C Disease 0.975 0.697 0.03 59 0.871 Q9UBP0 G370R Disease 0.969 0.764 0.17 55 0.963 Q9UBP0 G559D Disease 0.240 0.437 0.27 32 0.413 Q9UBP0 I344K Disease 0.851 0.803 0.00 71 0.919 Q9UBP0 I406V Disease 0.221 0.393 0.48 11 0.318 Q9UBP0 K388R Disease 0.975 0.790 0.02 52 0.862 Q9UBP0 L195V Disease NA 0.299 0.10 45 0.478 Q9UBP0 L378Q Disease 0.794 0.530 0.00 10 0.778 Q9UBP0 L426V Disease 0.773 0.425 0.22 23 0.499 Q9UBP0 L534P Disease 0.832 0.880 0.03 49 0.919 Q9UBP0 M390V Disease 0.224 0.411 0.01 34 0.424 Q9UBP0 N386K Disease 0.555 0.414 0.01 57 0.656 Q9UBP0 N386S Disease 0.520 0.421 0.04 12 0.562 Q9UBP0 P361L Disease 0.989 0.889 0.04 49 0.850 Q9UBP0 P435L Disease 0.774 0.904 0.00 47 0.859 Q9UBP0 P489L Disease 0.989 0.850 0.04 54 0.883 Q9UBP0 Q347K Disease 0.435 0.506 0.02 38 0.766 Q9UBP0 R424G Disease 0.807 0.671 0.00 42 0.820 Q9UBP0 R459G Disease 0.684 0.683 0.16 51 0.670 Q9UBP0 R460C Disease 0.993 0.816 0.00 54 0.943 Q9UBP0 R460L Disease 0.983 0.871 0.00 46 0.927 Q9UBP0 R499C Disease 0.974 0.879 0.00 66 0.908 Q9UBP0 R499H Disease 0.940 0.892 0.00 59 0.892 Q9UBP0 R503L Disease 0.673 0.596 0.43 54 0.794 Q9UBP0 R503W Disease 0.912 0.863 0.04 59 0.845 Q9UBP0 R562G Disease 0.908 0.824 0.00 49 0.908 Q9UBP0 R562Q Disease 0.880 0.813 0.03 42 0.792 Q9UBP0 S362C Disease 0.671 0.234 0.05 -3 0.485 Q9UBP0 S399L Disease 0.470 0.578 0.41 21 0.427 Q9UBP0 S407R Disease 0.798 0.741 0.05 56 0.700 Q9UBP0 S436F Disease 0.872 0.711 0.02 50 0.886 Q9UBP0 T614I Disease NA 0.158 0.01 0 0.219 Q9UBP0 T615I Disease NA 0.211 0.02 19 0.383 Q9UBP0 W607C Disease 0.983 0.912 0.00 59 0.954 Q9UBP4 E49D Polymorphism NA 0.092 0.00 13 0.111 Q9UBP5 V140M Polymorphism 0.457 0.168 0.11 7 0.183 Q9UBQ7 R170Q Polymorphism 0.183 0.713 0.33 -1 0.310 Q9UBR1 A85E Disease NA 0.349 0.27 12 0.422 Q9UBR1 A340D Polymorphism 0.891 0.824 0.02 47 0.883 Q9UBR4 Y111C Disease 0.862 0.842 0.00 70 0.928 Q9UBS0 P267L Polymorphism 0.849 0.514 0.65 11 0.690 Q9UBS4 I264V Polymorphism 0.086 0.172 0.32 8 0.208 Q9UBS5 A20V Polymorphism NA 0.070 0.00 -13 0.173 Q9UBS5 F645L Polymorphism 0.165 0.649 0.03 -23 0.387 Q9UBT6 I612V Polymorphism 0.081 0.077 0.02 -40 0.038 Q9UBT6 S423R Polymorphism 0.361 0.264 0.03 7 0.389 Q9UBT6 S635N Polymorphism 0.034 0.092 0.00 -28 0.089 Q9UBT6 S832N Polymorphism NA 0.115 NA 14 0.106 Q9UBT6 T595I Polymorphism 0.051 0.131 0.00 14 0.105 Q9UBT7 N91T Polymorphism 0.519 0.142 0.28 -28 0.335 Q9UBT7 E203K Polymorphism 0.784 0.293 0.62 -14 0.447 Q9UBT7 E527Q Polymorphism 0.352 0.117 0.13 4 0.115 Q9UBT7 T424S Polymorphism 0.274 0.282 0.22 -51 0.087 Q9UBU3 L72M Polymorphism 0.404 0.178 0.20 -13 0.155 Q9UBU3 Q90L Polymorphism 0.403 0.417 0.25 20 0.483 Q9UBU7 H575R Polymorphism 0.138 0.151 0.13 31 0.048 Q9UBU7 Y112N Polymorphism 0.572 0.298 0.55 26 0.516 Q9UBV2 V714I Polymorphism 0.245 0.262 0.63 23 0.324 Q9UBV4 G82R Polymorphism 0.085 0.732 0.07 12 0.172 Q9UBW5 S48N Polymorphism 0.106 0.081 0.14 -33 0.082 Q9UBW5 N529D Polymorphism 0.226 0.016 0.75 24 0.035 Q9UBX0 R160C Disease 0.996 0.913 0.00 76 0.959 Q9UBX1 Q153R Polymorphism NA 0.047 0.02 28 0.080 Q9UBX5 P87S Disease 0.096 0.212 0.73 32 0.122 Q9UBX5 R71Q Disease 0.250 0.184 0.03 50 0.290 Q9UBX5 V60L Disease 0.262 0.204 0.46 16 0.255 Q9UBX5 A363T Disease 0.446 0.302 0.11 -39 0.327 Q9UBX5 G412E Disease 0.867 0.833 0.40 20 0.778 Q9UBX5 I169T Disease 0.720 0.275 0.01 55 0.581 Q9UBX5 R351W Disease 0.913 0.513 0.03 58 0.910 Q9UBX5 S227P Disease 0.652 0.378 0.01 45 0.603 Q9UBX7 A32T Polymorphism NA 0.159 0.41 -37 0.104 Q9UBX7 G49E Polymorphism 0.323 0.746 0.81 -56 0.427 Q9UBX8 I379V Polymorphism 0.054 0.042 0.69 -26 0.078 Q9UBY8 H92Y Polymorphism 0.066 0.107 1.00 27 0.056 Q9UBY8 L16M Disease 0.159 0.060 0.00 -14 0.082 Q9UBY8 R24G Disease 0.377 0.582 0.00 29 0.694 Q9UBY8 G237R Disease 0.722 0.694 0.10 61 0.894 Q9UBY8 R204C Disease 0.831 0.744 0.13 73 0.939 Q9UBY8 T170M Disease 0.681 0.149 0.01 62 0.403 Q9UBY8 W263C Disease 0.851 0.715 0.18 47 0.862 Q9UBY8 Y158C Disease 0.821 0.587 0.01 64 0.928 Q9UBZ4 R141C Polymorphism NA 0.345 0.00 62 0.279 Q9UBZ9 D700N Polymorphism 0.317 0.157 0.10 9 0.227 Q9UBZ9 F257S Polymorphism NA 0.118 0.45 7 0.067 Q9UBZ9 L660W Polymorphism 0.927 0.881 0.00 50 0.922 Q9UBZ9 M656V Polymorphism 0.125 0.565 0.03 36 0.311 Q9UBZ9 N306D Polymorphism NA 0.088 0.00 11 0.174 Q9UBZ9 N373S Polymorphism NA 0.118 0.00 -10 0.210 Q9UBZ9 P902S Polymorphism NA 0.196 0.00 -23 0.219 Q9UBZ9 S921I Polymorphism NA 0.140 0.01 14 0.247 Q9UBZ9 V138M Polymorphism NA 0.151 0.03 -4 0.240 Q9UBZ9 L1102P Polymorphism NA 0.290 0.00 14 0.251 Q9UBZ9 N1074K Polymorphism NA 0.155 0.00 0 0.146 Q9UBZ9 N1091T Polymorphism NA 0.097 0.04 8 0.117 Q9UBZ9 P1060T Polymorphism NA 0.176 0.00 8 0.255 Q9UDT6 D961E Polymorphism 0.274 0.080 1.00 9 0.064 Q9UDT6 R977P Polymorphism 0.145 0.047 0.22 20 0.018 Q9UDV6 H293Y Polymorphism NA 0.450 0.35 49 0.422 Q9UDV7 M273V Polymorphism 0.048 0.118 0.60 -11 0.081 Q9UDX3 S3G Polymorphism NA 0.065 0.32 -56 0.237 Q9UDX3 E211K Polymorphism 0.434 0.865 0.03 23 0.646 Q9UDX3 R124G Polymorphism 0.213 0.556 0.24 41 0.617 Q9UDX4 R214H Polymorphism 0.464 0.454 0.07 36 0.538 Q9UDY2 V48A Disease NA 0.353 0.00 49 0.651 Q9UDY2 M668I Polymorphism 0.239 0.256 0.24 38 0.338 Q9UDY6 R65H Polymorphism 0.616 0.141 0.24 23 0.382 Q9UEE5 E126D Polymorphism 0.100 0.168 0.58 -16 0.129 Q9UEE5 M167T Polymorphism 0.344 0.416 0.36 15 0.364 Q9UEF7 F45V Polymorphism 0.123 0.455 0.11 19 0.348 Q9UEF7 C370S Polymorphism 0.142 0.364 0.57 14 0.149 Q9UEF7 F352V Polymorphism 0.544 0.820 0.08 53 0.614 Q9UEW3 F282S Polymorphism 0.091 0.248 0.75 2 0.030 Q9UF12 P91R Polymorphism NA 0.148 0.02 28 0.148 Q9UF12 R525Q Polymorphism 0.725 0.959 0.00 26 0.869 Q9UF33 F703S Polymorphism NA 0.415 0.00 11 0.399 Q9UFD9 R1419C Polymorphism 0.052 0.469 0.01 46 0.434 Q9UFF9 L32P Polymorphism 0.179 0.624 0.25 4 0.248 Q9UFN0 R100Q Polymorphism 0.394 0.450 0.37 54 0.297 Q9UG01 R953H Polymorphism 0.546 0.092 0.08 10 0.098 Q9UG22 V74F Polymorphism 0.323 0.373 0.29 -23 0.404 Q9UG22 H161R Polymorphism 0.219 0.318 0.57 -24 0.171 Q9UGC7 R76Q Polymorphism 0.109 0.631 0.45 -44 0.093 Q9UGC7 T38A Polymorphism 0.070 0.071 0.72 -56 0.026 Q9UGC7 L177F Polymorphism 0.595 0.293 0.37 -37 0.440 Q9UGF5 V278M Polymorphism 0.474 0.677 0.05 -3 0.451 Q9UGF6 I45M Polymorphism 0.231 0.467 1.00 -14 0.308 Q9UGF6 L23W Polymorphism 0.363 0.738 0.05 3 0.480 Q9UGF7 T97I Polymorphism 0.695 0.749 0.41 11 0.666 Q9UGF7 Y277H Polymorphism 0.780 0.908 0.00 62 0.829 Q9UGI8 A221V Polymorphism NA 0.243 0.07 38 0.326 Q9UGI9 P71A Polymorphism NA 0.081 0.27 5 0.054 Q9UGI9 R340W Polymorphism 0.874 0.284 0.02 25 0.603 Q9UGJ0 M6L Polymorphism NA 0.157 NA -4 0.186 Q9UGJ0 H383R Disease 0.602 0.696 0.15 34 0.555 Q9UGJ0 N488I Disease 0.688 0.826 0.07 8 0.780 Q9UGJ0 R302Q Disease 0.636 0.545 0.08 53 0.777 Q9UGJ0 R531G Disease 0.922 0.952 0.00 45 0.901 Q9UGJ0 R531Q Disease 0.939 0.922 0.01 40 0.904 Q9UGJ0 T400N Disease 0.942 0.948 0.01 52 0.946 Q9UGK3 D93N Polymorphism 0.062 0.051 0.33 -35 0.074 Q9UGK8 G457E Polymorphism NA 0.210 0.00 47 0.124 Q9UGK8 K429E Polymorphism 0.090 0.110 0.67 -11 0.051 Q9UGL9 C96Y Polymorphism NA 0.475 NA 61 0.370 Q9UGM3 P42T Polymorphism NA 0.309 0.86 33 0.334 Q9UGM3 P65L Polymorphism NA 0.195 0.18 39 0.308 Q9UGM3 S52W Polymorphism NA 0.330 0.01 42 0.486 Q9UGM3 S54L Polymorphism NA 0.082 0.30 31 0.135 Q9UGM3 V60A Polymorphism NA 0.199 0.16 27 0.180 Q9UGM3 N322D Polymorphism NA 0.465 0.17 48 0.443 Q9UGM3 P357S Polymorphism NA 0.432 0.73 35 0.398 Q9UGM3 P856S Polymorphism NA 0.377 0.73 -24 0.237 Q9UGM3 Q337L Polymorphism NA 0.163 0.29 26 0.249 Q9UGM3 R364G Polymorphism NA 0.651 0.00 54 0.932 Q9UGM3 R656W Polymorphism NA 0.558 0.18 60 0.518 Q9UGM3 R670C Polymorphism NA 0.441 0.06 53 0.713 Q9UGM3 T649M Polymorphism NA 0.331 0.14 53 0.528 Q9UGM3 T719M Polymorphism NA 0.212 0.11 43 0.407 Q9UGM3 T780M Polymorphism NA 0.340 0.12 46 0.438 Q9UGM3 H1084Y Polymorphism 0.732 0.864 0.00 61 0.898 Q9UGM3 M1169T Polymorphism 0.110 0.221 0.59 34 0.139 Q9UGM3 R1176W Polymorphism 0.598 0.365 0.22 56 0.660 Q9UGM3 R1434W Polymorphism 0.661 0.446 0.17 39 0.570 Q9UGM3 R1860L Polymorphism 0.149 0.785 0.33 38 0.341 Q9UGM3 S1095P Polymorphism 0.240 0.337 0.68 17 0.289 Q9UGM3 S1102T Polymorphism 0.081 0.060 0.57 32 0.093 Q9UGM3 T1961P Polymorphism 0.319 0.384 0.22 33 0.500 Q9UGM3 V1545M Polymorphism 0.495 0.623 0.00 49 0.795 Q9UGM3 V2255M Polymorphism NA 0.333 0.00 37 0.433 Q9UGM5 K360R Polymorphism 0.254 0.021 0.28 -16 0.043 Q9UGM6 L360P Polymorphism NA 0.892 0.00 22 0.846 Q9UGN5 D235G Polymorphism 0.628 0.514 0.24 5 0.730 Q9UGN5 I331T Polymorphism 0.413 0.148 0.52 0 0.239 Q9UGN5 R296Q Polymorphism 0.269 0.298 0.46 10 0.347 Q9UGP4 G36D Polymorphism NA 0.375 NA 55 0.408 Q9UGP4 G415R Polymorphism 0.077 0.228 0.12 47 0.287 Q9UGR2 D379N Polymorphism 0.425 0.126 NA -33 0.112 Q9UGT4 S110T Polymorphism 0.088 0.072 0.21 -5 0.082 Q9UGU0 S722G Polymorphism 0.274 0.081 NA 0 0.036 Q9UGU0 T485N Polymorphism 0.369 0.083 0.21 39 0.071 Q9UGU0 Y1910C Polymorphism 0.762 0.842 0.00 63 0.916 Q9UH17 P98L Polymorphism 0.638 0.174 0.40 -30 0.419 Q9UH17 R351H Polymorphism NA 0.172 0.56 -71 0.099 Q9UH17 S109A Polymorphism 0.093 0.103 1.00 -68 0.100 Q9UH17 T146K Polymorphism 0.083 0.168 1.00 -35 0.073 Q9UH36 A99T Polymorphism NA 0.053 0.28 -43 0.062 Q9UH65 Q505E Polymorphism 0.065 0.060 0.99 -28 0.058 Q9UH99 L89R Polymorphism NA 0.484 NA 56 0.734 Q9UH99 T33A Polymorphism NA 0.168 NA 5 0.170 Q9UH99 R348C Polymorphism NA 0.171 0.03 31 0.309 Q9UHA7 Q12R Polymorphism 0.155 0.036 0.64 9 0.086 Q9UHA7 G134R Polymorphism 0.679 0.175 0.55 6 0.182 Q9UHB4 V522I Polymorphism 0.206 0.058 1.00 -3 0.060 Q9UHB7 T136P Polymorphism 0.531 0.126 0.34 6 0.280 Q9UHC1 Q24E Disease NA 0.837 0.00 36 0.862 Q9UHC1 R93G Polymorphism 0.607 0.937 0.00 62 0.935 Q9UHC1 E624Q Disease 0.234 0.167 NA 29 0.159 Q9UHC1 F120S Polymorphism 0.638 0.326 0.10 43 0.583 Q9UHC1 G981S Disease NA 0.072 NA -46 0.006 Q9UHC1 H494R Polymorphism 0.106 0.098 0.01 30 0.124 Q9UHC1 K231Q Polymorphism 0.440 0.264 0.17 32 0.220 Q9UHC1 L492V Polymorphism 0.131 0.157 0.00 33 0.159 Q9UHC1 N499S Disease 0.108 0.086 0.00 22 0.109 Q9UHC1 P844L Polymorphism NA 0.068 NA 16 0.118 Q9UHC1 R600Q Polymorphism 0.079 0.099 NA -17 0.027 Q9UHC1 R647C Disease 0.429 0.059 NA -6 0.028 Q9UHC1 R797H Polymorphism NA 0.093 NA -36 0.024 Q9UHC1 S817G Disease NA 0.059 NA 6 0.074 Q9UHC1 S845G Polymorphism NA 0.072 NA -5 0.095 Q9UHC1 S966P Polymorphism NA 0.089 NA -40 0.045 Q9UHC1 T606P Polymorphism 0.114 0.272 NA 13 0.330 Q9UHC1 T942I Polymorphism NA 0.161 NA 4 0.133 Q9UHC1 V420I Polymorphism 0.162 0.047 0.06 17 0.074 Q9UHC1 V723I Polymorphism 0.209 0.125 NA -24 0.088 Q9UHC1 V741F Polymorphism NA 0.190 NA 24 0.363 Q9UHC1 Y720C Polymorphism 0.387 0.073 NA -31 0.046 Q9UHC1 A1394T Disease 0.524 0.595 0.08 23 0.728 Q9UHC1 D1073N Polymorphism NA 0.165 0.02 42 0.259 Q9UHC1 D1105E Polymorphism NA 0.351 0.00 22 0.240 Q9UHC1 E1451K Disease NA 0.340 NA 22 0.440 Q9UHC1 G1163D Polymorphism NA 0.305 0.02 37 0.286 Q9UHC1 G1319R Polymorphism 0.829 0.275 0.01 53 0.488 Q9UHC1 N1007S Disease NA 0.028 NA -34 0.009 Q9UHC6 G731S Polymorphism 0.893 0.868 0.03 15 0.819 Q9UHC6 L226M Polymorphism 0.259 0.312 0.20 21 0.354 Q9UHC6 N407S Polymorphism 0.075 0.509 0.71 -9 0.081 Q9UHC6 N418D Polymorphism 0.279 0.632 0.15 0 0.373 Q9UHC6 R114Q Polymorphism 0.248 0.235 0.32 17 0.234 Q9UHC6 S382N Polymorphism 0.398 0.737 0.20 39 0.595 Q9UHC6 T218M Polymorphism 0.412 0.794 0.02 50 0.867 Q9UHC6 Y716C Polymorphism 0.749 0.518 0.18 39 0.786 Q9UHC6 D1038N Polymorphism NA 0.173 0.50 17 0.137 Q9UHC6 D1129H Polymorphism 0.589 0.922 0.01 70 0.924 Q9UHC6 I1253T Polymorphism 0.396 0.579 0.01 -13 0.504 Q9UHC6 S1114G Polymorphism 0.316 0.279 0.36 -20 0.359 Q9UHC6 T1278I Polymorphism 0.378 0.214 0.78 -44 0.132 Q9UHC6 V1102A Polymorphism 0.301 0.092 0.07 24 0.248 Q9UHC7 V243L Polymorphism 0.160 0.327 0.03 16 0.328 Q9UHC7 V439A Polymorphism 0.127 0.171 0.55 -33 0.159 Q9UHC9 M510I Polymorphism 0.328 0.158 0.42 14 0.153 Q9UHD1 A329D Polymorphism 0.052 0.086 0.59 -5 0.031 Q9UHD2 K291E Polymorphism 0.637 0.617 0.37 46 0.650 Q9UHD2 K570Q Polymorphism 0.138 0.235 0.02 37 0.305 Q9UHD2 N388D Polymorphism 0.074 0.189 0.70 23 0.145 Q9UHD2 R271Q Polymorphism 0.060 0.084 0.64 -8 0.083 Q9UHD8 M576V Polymorphism 0.177 0.097 0.48 7 0.118 Q9UHD8 P145L Polymorphism NA 0.121 0.01 21 0.168 Q9UHD8 R106W Disease NA 0.374 0.00 30 0.588 Q9UHD8 S111F Disease NA 0.136 0.00 21 0.212 Q9UHF1 A186G Polymorphism 0.312 0.264 0.45 24 0.324 Q9UHF1 P183S Polymorphism 0.219 0.116 0.39 -5 0.128 Q9UHF1 V153I Polymorphism 0.083 0.236 0.41 1 0.192 Q9UHF7 A919T Disease 0.312 0.907 0.00 32 0.666 Q9UHF7 R908P Disease 0.598 0.975 0.00 56 0.905 Q9UHF7 R908Q Disease 0.382 0.948 0.00 51 0.865 Q9UHF7 R952C Disease 0.766 0.246 0.01 42 0.587 Q9UHF7 R952H Disease 0.554 0.222 0.01 35 0.558 Q9UHF7 S654L Polymorphism NA 0.079 0.01 29 0.110 Q9UHF7 T901P Disease 0.502 0.958 0.05 51 0.840 Q9UHF7 V894D Disease 0.628 0.635 0.00 48 0.797 Q9UHG0 S221G Polymorphism 0.222 0.131 0.32 -36 0.129 Q9UHG3 S465G Polymorphism NA 0.832 0.00 49 0.841 Q9UHG3 T414S Polymorphism NA 0.104 0.78 -44 0.126 Q9UHI7 I218V Polymorphism 0.371 0.513 0.60 -27 0.399 Q9UHI7 V264M Polymorphism 0.484 0.597 0.08 -23 0.492 Q9UHK0 S36R Polymorphism 0.093 0.152 0.24 30 0.109 Q9UHK6 V9M Polymorphism NA 0.769 0.02 40 0.830 Q9UHK6 S52P Disease 0.894 0.877 0.02 42 0.860 Q9UHK6 G175D Polymorphism 0.898 0.941 0.00 63 0.863 Q9UHK6 L107P Disease 0.864 0.849 0.00 42 0.856 Q9UHK6 M261I Polymorphism 0.282 0.299 0.40 18 0.221 Q9UHK6 P238S Polymorphism 0.497 0.317 0.11 18 0.406 Q9UHK6 Q239H Polymorphism 0.743 0.475 0.13 27 0.612 Q9UHK6 R118Q Polymorphism 0.247 0.117 0.74 -45 0.112 Q9UHL4 A89G Polymorphism 0.101 0.478 1.00 -41 0.049 Q9UHM6 P10L Polymorphism NA 0.065 0.94 -2 0.039 Q9UHM6 G444D Polymorphism NA 0.102 0.62 31 0.079 Q9UHN1 A169T Polymorphism 0.303 0.041 0.62 16 0.091 Q9UHN1 G451E Disease 0.370 0.275 0.39 39 0.380 Q9UHN6 D423E Polymorphism 0.180 0.490 0.38 11 0.300 Q9UHN6 R245K Polymorphism 0.114 0.029 0.78 -7 0.046 Q9UHN6 I1010V Polymorphism 0.272 0.199 0.00 -17 0.212 Q9UHN6 S1254N Polymorphism 0.421 0.210 0.12 29 0.296 Q9UHP6 T42M Polymorphism 0.655 0.140 0.13 46 0.272 Q9UHR4 S460T Polymorphism 0.145 0.224 0.32 -22 0.198 Q9UHW5 A52V Polymorphism 0.092 0.182 1.00 -14 0.066 Q9UHW9 F415S Polymorphism NA 0.536 0.06 15 0.475 Q9UHX3 L614F Polymorphism 0.066 0.500 1.00 -30 0.023 Q9UHX3 S665F Polymorphism 0.218 0.576 0.06 28 0.434 Q9UHX3 T605I Polymorphism 0.254 0.410 0.38 30 0.136 Q9UHY1 H460R Polymorphism 0.210 0.110 0.42 5 0.222 Q9UHY8 R329C Polymorphism 0.510 0.116 0.18 4 0.267 Q9UI10 A93V Polymorphism NA 0.075 0.00 -24 0.155 Q9UI10 A228V Disease 0.657 0.827 0.14 32 0.857 Q9UI10 C465R Disease 0.150 0.463 0.36 -3 0.266 Q9UI10 R357Q Disease 0.368 0.662 0.05 14 0.527 Q9UI10 R374C Disease 0.880 0.677 0.18 23 0.811 Q9UI10 Y489H Disease 0.724 0.742 0.01 52 0.820 Q9UI17 H109R Disease 0.353 0.432 0.12 4 0.392 Q9UI17 S279P Polymorphism 0.078 0.537 0.23 -61 0.033 Q9UI26 N260D Polymorphism 0.200 0.229 0.92 38 0.191 Q9UI33 G481E Polymorphism 0.142 0.265 1.00 21 0.247 Q9UI33 M777R Polymorphism 0.885 0.691 0.00 60 0.959 Q9UI33 Y1198H Polymorphism 0.245 0.616 0.04 31 0.357 Q9UI38 Q75P Polymorphism NA 0.153 0.29 43 0.123 Q9UI42 L27F Polymorphism 0.139 0.617 0.49 -61 0.163 Q9UI42 G303C Polymorphism 0.072 0.782 0.09 -3 0.125 Q9UI42 P157T Polymorphism 0.648 0.860 0.31 -13 0.600 Q9UI42 R183L Polymorphism 0.985 0.918 0.00 50 0.905 Q9UI46 G515S Disease 0.628 0.887 0.03 28 0.773 Q9UI46 Q326H Polymorphism NA 0.280 0.60 -11 0.219 Q9UI46 V335I Polymorphism 0.525 0.437 0.11 21 0.539 Q9UIA0 M74V Polymorphism 0.300 0.529 0.36 -7 0.302 Q9UIA9 C835Y Polymorphism 0.268 0.801 0.10 49 0.823 Q9UIA9 E398D Polymorphism 0.114 0.345 0.66 -3 0.190 Q9UIE0 F434Y Polymorphism 0.202 0.287 1.00 -62 0.062 Q9UIE0 S310C Polymorphism 0.207 0.288 1.00 -36 0.037 Q9UIF7 V22M Polymorphism NA 0.180 0.00 20 0.186 Q9UIF7 A370V Polymorphism 0.153 0.203 0.42 -8 0.190 Q9UIF7 G393D Disease 0.322 0.940 0.04 59 0.736 Q9UIF7 G500E Polymorphism 0.079 0.294 0.00 36 0.340 Q9UIF7 L526M Polymorphism 0.295 0.181 0.00 23 0.262 Q9UIF7 P402S Disease 0.195 0.746 0.00 56 0.812 Q9UIF7 Q335H Polymorphism 0.385 0.120 0.18 34 0.241 Q9UIF7 Q411R Disease 0.164 0.206 0.11 4 0.212 Q9UIF7 R531Q Polymorphism 0.056 0.104 0.68 14 0.072 Q9UIF7 S512F Polymorphism 0.384 0.139 0.03 19 0.170 Q9UIF7 W128R Disease 0.805 0.876 0.01 28 0.851 Q9UIF7 Y176C Disease 0.958 0.900 0.00 60 0.934 Q9UIF8 G702V Polymorphism 0.453 0.183 0.22 23 0.152 Q9UIF8 L422S Polymorphism NA 0.125 NA -30 0.006 Q9UIF8 S2024N Polymorphism NA 0.137 0.17 37 0.228 Q9UIG4 P84L Polymorphism NA 0.112 0.28 45 0.125 Q9UIG5 E34K Polymorphism NA 0.132 NA 17 0.053 Q9UIG5 E34Q Polymorphism NA 0.209 NA 6 0.035 Q9UIG5 P24T Polymorphism NA 0.093 NA 3 0.050 Q9UIG5 S66C Polymorphism NA 0.123 NA 11 0.037 Q9UII6 R62Q Polymorphism 0.236 0.405 0.60 -15 0.259 Q9UII6 C156Y Polymorphism 0.176 0.615 1.00 -13 0.215 Q9UII6 R190G Polymorphism 0.458 0.664 0.23 20 0.738 Q9UIK4 R271W Polymorphism 0.463 0.713 0.02 20 0.405 Q9UIL4 K28M Polymorphism NA 0.808 0.23 26 0.686 Q9UIL4 A255T Polymorphism NA 0.168 0.59 23 0.156 Q9UIQ6 I963V Polymorphism 0.314 0.183 0.27 13 0.258 Q9UIR0 A352T Polymorphism 0.329 0.641 0.00 3 0.517 Q9UIR0 P379L Polymorphism 0.104 0.201 1.00 -2 0.122 Q9UIR0 P393Q Polymorphism 0.087 0.281 0.45 -14 0.022 Q9UIR0 S334L Polymorphism 0.464 0.886 0.21 7 0.605 Q9UIR0 V188M Polymorphism 0.243 0.240 0.21 42 0.307 Q9UIU6 H605P Polymorphism NA 0.187 0.35 18 0.179 Q9UIV8 G293S Polymorphism 0.215 0.127 1.00 -34 0.082 Q9UIW0 P254R Polymorphism 0.127 0.424 0.00 52 0.442 Q9UJ04 R30L Polymorphism NA 0.092 0.22 -24 0.025 Q9UJ71 A55V Polymorphism NA 0.145 0.01 12 0.137 Q9UJ71 N288D Polymorphism 0.423 0.576 0.13 17 0.457 Q9UJ71 Q136E Polymorphism NA 0.169 1.00 3 0.115 Q9UJA3 E341K Polymorphism 0.094 0.286 0.78 29 0.177 Q9UJA3 S365N Polymorphism NA 0.217 0.50 -17 0.220 Q9UJA9 I171V Polymorphism 0.165 0.345 0.32 -12 0.197 Q9UJA9 Y283C Polymorphism 0.950 0.869 0.01 41 0.889 Q9UJN7 G59C Polymorphism 0.598 0.512 0.02 24 0.774 Q9UJQ1 I81V Polymorphism NA 0.263 0.47 20 0.182 Q9UJQ1 S158G Polymorphism NA 0.111 0.15 21 0.076 Q9UJQ4 H888R Disease 0.958 0.902 0.00 71 0.945 Q9UJQ4 I798L Polymorphism 0.152 0.095 0.68 28 0.158 Q9UJQ4 L507R Polymorphism 0.528 0.618 0.63 35 0.447 Q9UJQ7 P99S Polymorphism 0.220 0.305 0.78 -12 0.231 Q9UJS0 E141K Polymorphism NA 0.164 0.30 -17 0.134 Q9UJS0 E601K Disease 0.584 0.784 0.00 69 0.783 Q9UJT1 M76T Polymorphism NA 0.652 0.32 6 0.353 Q9UJT2 E167K Polymorphism NA 0.402 0.00 35 0.148 Q9UJU3 F159L Polymorphism NA 0.293 0.44 3 0.323 Q9UJU3 G163E Polymorphism NA 0.756 1.00 38 0.619 Q9UJV8 E143K Polymorphism 0.453 0.131 0.00 44 0.107 Q9UJW0 P95T Polymorphism 0.155 0.129 NA -19 0.125 Q9UJW0 Y263C Polymorphism 0.531 0.377 NA 13 0.560 Q9UJW2 T3A Polymorphism NA 0.130 0.00 -50 0.038 Q9UJW2 I433L Polymorphism 0.199 0.179 0.84 -26 0.144 Q9UJW2 V413I Polymorphism 0.375 0.353 0.28 6 0.357 Q9UJW3 R278G Polymorphism 0.763 0.901 0.01 21 0.867 Q9UJW7 R337C Polymorphism 0.811 0.783 0.12 7 0.824 Q9UJW8 A41V Polymorphism NA 0.145 0.52 -20 0.081 Q9UJW8 C272S Polymorphism 0.579 0.508 0.24 -19 0.237 Q9UJX0 E439D Polymorphism NA 0.211 0.54 0 0.185 Q9UJX2 P9L Polymorphism NA 0.186 NA -4 0.120 Q9UJX5 E800G Polymorphism 0.407 0.137 NA 44 0.063 Q9UJX5 R465Q Polymorphism 0.140 0.186 NA 25 0.182 Q9UJY1 R78M Polymorphism 0.322 0.215 0.26 21 0.332 Q9UJY1 K141E Disease 0.406 0.443 0.00 47 0.636 Q9UJY1 K141N Disease 0.492 0.398 0.00 41 0.626 Q9UJY4 A424P Polymorphism 0.409 0.128 0.31 -19 0.063 Q9UJZ1 L129P Polymorphism 0.964 0.889 0.03 62 0.929 Q9UK10 Q50R Polymorphism 0.190 0.179 0.39 32 0.278 Q9UK10 T679S Polymorphism NA 0.620 0.19 -41 0.177 Q9UK12 K50E Polymorphism 0.481 0.669 0.69 11 0.366 Q9UK22 K118T Polymorphism NA 0.253 0.14 3 0.364 Q9UK32 D692N Polymorphism NA 0.153 0.45 -14 0.120 Q9UK39 H140Y Polymorphism 0.350 0.268 0.10 27 0.355 Q9UK53 A335D Disease NA 0.332 0.15 22 0.320 Q9UK53 C358S Disease 0.907 0.940 0.00 70 0.952 Q9UK53 L125R Polymorphism NA 0.263 NA 22 0.055 Q9UK53 N359S Disease 0.424 0.601 0.04 37 0.601 Q9UK55 S61G Polymorphism NA 0.268 0.17 -31 0.356 Q9UK55 G139R Polymorphism NA 0.809 0.13 0 0.547 Q9UK55 R196H Polymorphism 0.314 0.333 0.06 -5 0.365 Q9UK61 A831G Polymorphism NA 0.091 0.46 4 0.063 Q9UK61 V998I Polymorphism NA 0.085 0.41 29 0.057 Q9UK61 T1046R Polymorphism NA 0.146 0.25 -19 0.030 Q9UK80 P91S Polymorphism 0.175 0.105 0.55 21 0.052 Q9UK80 G321D Polymorphism 0.247 0.618 0.64 27 0.351 Q9UK80 P336T Polymorphism 0.298 0.230 0.47 -17 0.272 Q9UK85 L24R Polymorphism NA 0.478 NA 36 0.445 Q9UKA4 H1070R Polymorphism 0.109 0.095 NA 27 0.075 Q9UKB3 C129W Polymorphism 0.201 0.096 0.06 43 0.042 Q9UKB3 M124I Polymorphism 0.101 0.036 0.84 14 0.025 Q9UKB5 G263R Polymorphism NA 0.106 0.00 15 0.059 Q9UKE5 A999T Polymorphism NA 0.169 0.77 34 0.092 Q9UKE5 G910E Polymorphism NA 0.170 1.00 0 0.110 Q9UKF2 L359P Polymorphism 0.408 0.716 0.29 20 0.413 Q9UKG1 E700G Polymorphism NA 0.120 0.12 18 0.107 Q9UKG4 P451S Polymorphism 0.468 0.155 0.22 23 0.267 Q9UKG9 V474L Polymorphism 0.242 0.235 0.58 -22 0.215 Q9UKI3 R4W Polymorphism 0.698 0.036 0.03 -46 0.034 Q9UKJ1 S279L Polymorphism NA 0.157 NA -11 0.040 Q9UKJ3 C1161W Polymorphism NA 0.196 0.05 44 0.194 Q9UKK3 A899T Polymorphism NA 0.393 0.19 40 0.468 Q9UKK3 F215Y Polymorphism 0.153 0.375 NA -12 0.181 Q9UKK3 K991R Polymorphism NA 0.196 0.14 -11 0.201 Q9UKK3 S122N Polymorphism 0.270 0.071 NA -15 0.071 Q9UKK3 G1265A Polymorphism NA 0.066 0.01 -23 0.090 Q9UKK3 S1253T Polymorphism NA 0.156 0.08 13 0.142 Q9UKK3 V1012I Polymorphism NA 0.286 0.02 -18 0.118 Q9UKL3 P1659S Polymorphism 0.065 0.057 NA -37 0.035 Q9UKL6 E10A Polymorphism NA 0.196 0.05 24 0.216 Q9UKM9 V139M Polymorphism 0.533 0.146 0.02 -17 0.358 Q9UKN7 C1977R Polymorphism 0.232 0.777 0.54 -4 0.369 Q9UKN7 G2018R Polymorphism NA 0.224 0.61 9 0.096 Q9UKN7 I2113F Disease 0.114 0.913 0.03 22 0.709 Q9UKN7 N2111Y Disease 0.532 0.550 0.02 -33 0.578 Q9UKN7 Q2716H Disease 0.333 0.734 0.00 59 0.819 Q9UKN7 Y2682F Polymorphism 0.126 0.313 0.00 30 0.207 Q9UKP4 T307M Polymorphism 0.192 0.180 0.02 48 0.359 Q9UKP4 G1583A Polymorphism 0.107 0.379 0.78 -10 0.088 Q9UKP4 T1319A Polymorphism NA 0.063 NA 36 0.093 Q9UKQ2 E226D Polymorphism 0.267 0.105 0.19 -7 0.242 Q9UKQ2 T604P Polymorphism 0.971 0.874 0.00 21 0.935 Q9UKR8 L55P Polymorphism NA 0.865 0.29 37 0.607 Q9UKR8 S233C Polymorphism NA 0.218 0.00 33 0.158 Q9UKS6 A61V Polymorphism 0.693 0.512 0.01 28 0.756 Q9UKT4 Q107E Polymorphism NA 0.030 1.00 -31 0.005 Q9UKT6 P209L Polymorphism NA 0.030 1.00 11 0.014 Q9UKU7 A320T Disease 0.902 0.878 0.00 43 0.876 Q9UKU7 D134Y Disease 0.345 0.431 1.00 -18 0.255 Q9UKU7 G137R Disease 0.982 0.901 0.00 71 0.925 Q9UKU7 M128I Disease 0.633 0.324 0.31 27 0.577 Q9UKU7 M152T Disease 0.337 0.333 0.11 52 0.633 Q9UKU7 Q385R Disease 0.489 0.584 0.19 39 0.739 Q9UKU7 R302Q Disease 0.969 0.937 0.00 74 0.926 Q9UKU7 R334C Disease 0.745 0.836 0.18 38 0.868 Q9UKU7 V203I Disease 0.714 0.443 0.09 13 0.543 Q9UKV3 R257K Polymorphism NA 0.193 0.14 -7 0.201 Q9UKV3 S467P Polymorphism NA 0.402 0.04 14 0.174 Q9UKV3 S478F Polymorphism NA 0.279 0.01 -4 0.181 Q9UKW4 P616S Polymorphism 0.562 0.121 0.37 33 0.316 Q9UKX2 E706K Disease 0.961 0.862 0.00 67 0.943 Q9UKX3 G701R Polymorphism 0.985 0.860 0.00 66 0.948 Q9UKX3 M1071V Polymorphism 0.313 0.236 0.36 6 0.339 Q9UKX3 R1294Q Polymorphism 0.291 0.069 1.00 -37 0.030 Q9UKX5 M471L Polymorphism 0.134 0.449 1.00 6 0.147 Q9UKY0 S6I Polymorphism 0.329 0.177 0.00 21 0.209 Q9UKY0 F70L Polymorphism 0.099 0.402 0.00 25 0.174 Q9UKY0 H31R Polymorphism 0.381 0.414 0.00 48 0.384 Q9UKY0 P56L Polymorphism 0.645 0.318 0.00 37 0.376 Q9UKY0 S22P Polymorphism 0.368 0.352 0.00 52 0.160 Q9UKY0 T26P Polymorphism 0.253 0.298 0.01 10 0.201 Q9UKY0 L149S Polymorphism 0.530 0.594 0.00 18 0.400 Q9UKY0 T174M Polymorphism 0.165 0.048 0.02 -42 0.025 Q9UKZ4 Y40H Polymorphism NA 0.438 0.00 61 0.695 Q9UKZ4 K641E Polymorphism 0.171 0.408 0.33 43 0.204 Q9UKZ4 M371T Polymorphism 0.090 0.104 1.00 3 0.051 Q9UKZ4 M632V Polymorphism 0.196 0.446 0.14 40 0.067 Q9UKZ9 V280A Polymorphism 0.089 0.399 0.84 19 0.208 Q9UL01 P34L Polymorphism NA 0.291 NA 19 0.150 Q9UL01 T25I Polymorphism NA 0.320 NA 26 0.172 Q9UL12 G22C Polymorphism NA 0.099 0.00 30 0.064 Q9UL12 E372D Polymorphism 0.173 0.270 0.01 1 0.252 Q9UL16 E291G Polymorphism 0.495 0.127 0.01 21 0.252 Q9UL17 H33Q Polymorphism NA 0.153 NA 41 0.066 Q9UL17 I339V Polymorphism 0.057 0.099 0.69 -23 0.056 Q9UL36 S643G Polymorphism NA 0.414 0.17 43 0.464 Q9UL41 R386Q Polymorphism 0.407 0.080 0.24 37 0.059 Q9UL42 E186K Polymorphism 0.343 0.140 0.16 11 0.251 Q9UL49 E380D Polymorphism NA 0.093 NA 26 0.087 Q9UL58 N36S Polymorphism 0.296 0.046 0.98 -40 0.016 Q9UL58 S263F Polymorphism 0.454 0.635 0.74 48 0.418 Q9UL59 Y66C Polymorphism 0.740 0.386 0.19 0 0.409 Q9UL59 H160R Polymorphism NA 0.205 0.47 -2 0.244 Q9UL59 I185R Polymorphism NA 0.574 0.46 44 0.525 Q9UL59 L128H Polymorphism NA 0.449 0.43 -10 0.414 Q9UL63 C469G Polymorphism 0.245 0.321 0.46 8 0.382 Q9ULB1 Y400N Polymorphism 0.579 0.668 0.39 42 0.562 Q9ULB4 Y6C Polymorphism NA 0.286 0.17 -46 0.095 Q9ULB4 A38V Polymorphism NA 0.170 0.28 -24 0.198 Q9ULC3 C85R Disease 0.411 0.742 0.01 63 0.700 Q9ULC3 K40R Polymorphism 0.254 0.249 0.02 7 0.333 Q9ULC3 G207S Polymorphism NA 0.470 0.67 -7 0.254 Q9ULC3 S101A Polymorphism 0.104 0.179 0.27 -17 0.152 Q9ULC5 M182V Polymorphism 0.664 0.255 0.61 -42 0.222 Q9ULD0 D573N Polymorphism 0.339 0.748 0.37 -5 0.471 Q9ULD0 N725S Polymorphism 0.374 0.843 0.16 0 0.476 Q9ULD0 P511L Polymorphism 0.790 0.881 0.01 26 0.804 Q9ULD0 T637M Polymorphism 0.588 0.573 0.05 -15 0.471 Q9ULD2 Q75K Disease NA 0.264 0.00 44 0.246 Q9ULD2 A563S Disease NA 0.224 0.05 -25 0.170 Q9ULD2 C148R Polymorphism NA 0.640 0.00 59 0.667 Q9ULD2 H575R Polymorphism NA 0.247 0.16 26 0.168 Q9ULD2 K453T Polymorphism NA 0.096 0.07 20 0.075 Q9ULD2 K911T Polymorphism NA 0.157 0.01 5 0.265 Q9ULD2 N873H Disease NA 0.025 0.12 -9 0.070 Q9ULD2 T425M Polymorphism NA 0.098 0.00 27 0.076 Q9ULD2 E1105Q Polymorphism NA 0.099 0.26 6 0.193 Q9ULD2 K1063T Polymorphism NA 0.175 0.01 34 0.259 Q9ULD2 Q1201R Disease NA 0.754 0.10 43 0.638 Q9ULD4 A278G Polymorphism 0.779 0.824 0.01 42 0.865 Q9ULE0 A495T Polymorphism NA 0.044 0.69 12 0.076 Q9ULE0 Y593C Polymorphism 0.786 0.673 0.03 40 0.702 Q9ULE3 I777T Polymorphism 0.176 0.126 0.81 -18 0.095 Q9ULE4 N952S Polymorphism NA 0.088 0.93 32 0.137 Q9ULE6 R721C Polymorphism NA 0.309 0.01 46 0.422 Q9ULE6 S141L Polymorphism NA 0.191 0.28 -14 0.191 Q9ULF5 T87S Polymorphism NA 0.171 0.25 -9 0.140 Q9ULG1 I882V Polymorphism NA 0.178 0.31 40 0.159 Q9ULG6 A517D Polymorphism 0.266 0.353 0.39 29 0.434 Q9ULG6 E161V Polymorphism 0.238 0.131 0.00 37 0.185 Q9ULG6 G553D Polymorphism 0.133 0.086 0.33 5 0.076 Q9ULG6 H673R Polymorphism 0.097 0.219 0.99 13 0.174 Q9ULG6 R436L Polymorphism 0.172 0.105 0.09 18 0.093 Q9ULG6 Y418H Polymorphism 0.278 0.066 0.55 12 0.030 Q9ULH0 I538T Polymorphism NA 0.613 0.00 8 0.546 Q9ULH0 Q1608H Polymorphism NA 0.291 0.00 15 0.251 Q9ULH0 R1307H Polymorphism NA 0.175 0.79 -1 0.128 Q9ULH1 I728V Polymorphism 0.230 0.215 1.00 -20 0.174 Q9ULH4 D770N Polymorphism NA 0.129 0.00 26 0.128 Q9ULI0 S118P Polymorphism NA 0.088 NA -29 0.040 Q9ULI1 L569M Polymorphism NA 0.224 0.00 36 0.319 Q9ULI3 Q145R Polymorphism NA 0.197 NA 34 0.258 Q9ULI3 V980L Polymorphism NA 0.089 0.47 -20 0.040 Q9ULJ1 K350R Polymorphism 0.141 0.140 0.95 22 0.154 Q9ULJ1 R177H Polymorphism 0.652 0.302 0.10 30 0.557 Q9ULJ3 K218Q Polymorphism NA 0.131 NA 31 0.105 Q9ULJ3 N185S Polymorphism NA 0.031 NA -14 0.030 Q9ULJ8 M331V Polymorphism NA 0.083 0.72 -8 0.062 Q9ULL4 V598I Polymorphism 0.158 0.254 0.44 -20 0.202 Q9ULL4 M1535T Polymorphism 0.185 0.129 0.71 13 0.120 Q9ULL8 R722H Polymorphism 0.382 0.168 0.12 14 0.102 Q9ULL8 S1089L Disease 0.320 0.066 NA 0 0.014 Q9ULM0 M438V Polymorphism 0.056 0.029 0.42 -22 0.011 Q9ULM3 Q993H Polymorphism NA 0.177 0.06 67 0.187 Q9ULM3 V530I Polymorphism 0.203 0.041 0.29 40 0.047 Q9ULT0 V538L Polymorphism 0.241 0.050 0.96 15 0.027 Q9ULT0 V545I Polymorphism 0.077 0.102 0.12 -12 0.122 Q9ULU4 V752A Polymorphism NA 0.090 0.00 -8 0.092 Q9ULV0 K307N Polymorphism NA 0.430 0.50 -20 0.201 Q9ULV0 R219H Disease 0.267 0.917 0.00 61 0.926 Q9ULV0 R656C Disease 0.662 0.886 0.00 61 0.921 Q9ULV0 R918H Polymorphism 0.499 0.215 0.07 6 0.380 Q9ULV0 V108G Disease 0.241 0.642 0.00 36 0.688 Q9ULV1 M105V Disease 0.555 0.546 1.00 0 0.345 Q9ULV1 M157V Disease 0.196 0.528 0.13 24 0.393 Q9ULV3 A219T Polymorphism 0.104 0.132 0.11 -39 0.055 Q9ULV3 S578F Polymorphism 0.598 0.156 NA 25 0.235 Q9ULV3 V638M Polymorphism 0.096 0.046 NA -52 0.072 Q9ULV8 H405Y Polymorphism 0.177 0.169 0.03 22 0.202 Q9ULW8 R618Q Polymorphism 0.338 0.261 0.36 -9 0.240 Q9ULW8 V171M Polymorphism 0.315 0.153 0.05 26 0.271 Q9ULX3 R231Q Polymorphism 0.261 0.029 1.00 -45 0.017 Q9UM01 T5I Disease NA 0.119 0.00 -6 0.172 Q9UM01 G54V Disease 0.995 0.939 0.99 61 0.936 Q9UM01 M50K Disease 0.766 0.957 0.00 66 0.942 Q9UM01 S53L Disease 0.851 0.934 0.33 42 0.902 Q9UM01 A140P Disease 0.812 0.932 0.01 58 0.869 Q9UM01 E251D Disease 0.921 0.715 0.63 53 0.868 Q9UM01 F152L Disease 0.152 0.272 0.68 -6 0.159 Q9UM01 G338D Disease 0.839 0.794 0.04 58 0.914 Q9UM01 K191E Disease 0.972 0.963 0.29 42 0.913 Q9UM01 L124P Disease 0.781 0.900 0.06 38 0.787 Q9UM01 L261P Disease 0.861 0.872 0.28 19 0.862 Q9UM01 L334R Disease 0.932 0.888 0.01 66 0.927 Q9UM01 N365Y Disease 0.469 0.414 0.46 22 0.416 Q9UM01 R333M Disease 0.997 0.943 0.00 74 0.954 Q9UM01 S238F Disease 0.834 0.898 0.00 50 0.921 Q9UM01 S386R Disease 0.665 0.848 0.21 46 0.876 Q9UM01 S489P Disease 0.513 0.768 0.00 -15 0.563 Q9UM01 T188I Disease 0.586 0.861 0.61 29 0.720 Q9UM07 D89N Polymorphism 0.515 0.382 0.15 40 0.563 Q9UM07 D260N Polymorphism 0.351 0.313 0.87 10 0.259 Q9UM07 M164T Polymorphism 0.163 0.137 0.30 -1 0.195 Q9UM07 P102T Polymorphism 0.376 0.371 0.21 -1 0.420 Q9UM07 R131T Polymorphism 0.238 0.380 0.34 27 0.384 Q9UM07 S275F Polymorphism 0.457 0.286 0.09 27 0.395 Q9UM13 R46Q Polymorphism 0.529 0.769 0.31 47 0.809 Q9UM44 N344K Polymorphism NA 0.072 0.04 34 0.092 Q9UM44 S364R Polymorphism NA 0.371 0.09 45 0.283 Q9UM47 C43G Disease NA 0.858 0.01 49 0.708 Q9UM47 C49F Disease NA 0.909 0.13 57 0.890 Q9UM47 C49Y Disease NA 0.940 0.05 71 0.930 Q9UM47 C65S Disease NA 0.848 0.00 59 0.921 Q9UM47 C67Y Disease NA 0.854 0.00 77 0.934 Q9UM47 C76R Disease NA 0.886 0.00 83 0.929 Q9UM47 C76W Disease NA 0.882 0.00 81 0.932 Q9UM47 C87R Disease NA 0.857 0.00 63 0.940 Q9UM47 C87Y Disease NA 0.882 0.00 71 0.942 Q9UM47 C93F Disease NA 0.743 0.00 62 0.927 Q9UM47 C93Y Disease NA 0.829 0.00 54 0.926 Q9UM47 R54C Disease NA 0.353 0.03 23 0.330 Q9UM47 R90C Disease NA 0.151 0.04 49 0.256 Q9UM47 S60C Disease NA 0.435 0.06 -3 0.190 Q9UM47 W71C Disease NA 0.325 0.00 56 0.684 Q9UM47 A319C Disease 0.825 0.198 0.06 2 0.536 Q9UM47 C106W Disease NA 0.778 0.00 73 0.957 Q9UM47 C108W Disease NA 0.794 0.00 78 0.970 Q9UM47 C108Y Disease NA 0.826 0.00 72 0.972 Q9UM47 C117F Disease NA 0.779 0.00 72 0.966 Q9UM47 C123F Disease NA 0.756 0.00 68 0.989 Q9UM47 C123Y Disease NA 0.814 0.00 67 0.992 Q9UM47 C128Y Disease NA 0.821 0.05 75 0.995 Q9UM47 C134W Disease NA 0.783 0.01 82 0.983 Q9UM47 C144F Disease NA 0.821 0.00 71 0.996 Q9UM47 C144S Disease NA 0.827 0.00 66 0.997 Q9UM47 C144Y Disease NA 0.846 0.00 66 0.997 Q9UM47 C146R Disease NA 0.875 0.02 78 0.996 Q9UM47 C155S Disease NA 0.824 0.01 53 0.966 Q9UM47 C162S Disease NA 0.788 0.07 45 0.872 Q9UM47 C174F Disease NA 0.824 0.00 71 0.996 Q9UM47 C174R Disease NA 0.847 0.00 81 0.996 Q9UM47 C174Y Disease NA 0.809 0.00 72 0.997 Q9UM47 C183F Disease NA 0.768 0.00 69 0.994 Q9UM47 C183R Disease NA 0.805 0.00 78 0.995 Q9UM47 C183S Disease NA 0.756 0.00 63 0.994 Q9UM47 C185G Disease NA 0.614 0.00 71 0.952 Q9UM47 C185R Disease NA 0.800 0.00 82 0.992 Q9UM47 C194F Disease NA 0.805 0.00 77 0.961 Q9UM47 C194R Disease NA 0.807 0.00 81 0.961 Q9UM47 C194S Disease NA 0.784 0.00 71 0.961 Q9UM47 C194Y Disease NA 0.793 0.00 76 0.974 Q9UM47 C201Y Disease NA 0.745 0.00 69 0.976 Q9UM47 C206Y Disease NA 0.706 0.00 75 0.990 Q9UM47 C212S Disease 0.583 0.709 0.00 68 0.950 Q9UM47 C222G Disease 0.837 0.540 0.00 69 0.960 Q9UM47 C222Y Disease 0.945 0.700 0.00 71 0.979 Q9UM47 C224Y Disease 0.996 0.722 0.00 77 0.994 Q9UM47 C233S Disease 0.826 0.746 0.00 65 0.927 Q9UM47 C233Y Disease 0.945 0.721 0.00 67 0.952 Q9UM47 C240S Disease 0.780 0.736 0.03 62 0.909 Q9UM47 C245R Disease 0.926 0.695 0.00 81 0.950 Q9UM47 C251R Disease 0.932 0.695 0.00 83 0.981 Q9UM47 C260Y Disease 0.994 0.782 0.00 72 0.995 Q9UM47 C379S Disease 0.999 0.702 0.00 64 0.938 Q9UM47 C395R Disease 0.996 0.681 0.00 69 0.974 Q9UM47 C428S Disease 0.848 0.306 0.00 62 0.843 Q9UM47 C428Y Disease 0.953 0.299 0.00 70 0.869 Q9UM47 C440G Disease 0.999 0.186 0.00 75 0.893 Q9UM47 C440R Disease 0.999 0.255 0.00 84 0.967 Q9UM47 C446S Disease 0.993 0.313 0.00 71 0.968 Q9UM47 C455R Disease 0.999 0.284 0.00 78 0.968 Q9UM47 C484F Disease 0.948 0.268 0.00 77 0.872 Q9UM47 C484Y Disease 0.958 0.265 0.00 78 0.851 Q9UM47 C495Y Disease 0.999 0.260 0.00 77 0.968 Q9UM47 C511R Disease 0.944 0.240 0.00 78 0.868 Q9UM47 C542Y Disease 0.869 0.255 0.00 70 0.859 Q9UM47 C549Y Disease 0.958 0.431 0.00 67 0.857 Q9UM47 C775S Disease 0.478 0.752 0.02 55 0.912 Q9UM47 F142C Disease NA 0.695 0.00 34 0.800 Q9UM47 F984C Disease NA 0.286 0.02 57 0.553 Q9UM47 G149C Disease NA 0.859 0.01 47 0.881 Q9UM47 G171C Disease NA 0.824 0.00 56 0.977 Q9UM47 G420C Disease 0.468 0.424 0.08 21 0.354 Q9UM47 G953C Disease NA 0.413 0.01 63 0.664 Q9UM47 H170R Polymorphism NA 0.614 0.05 54 0.529 Q9UM47 P496L Polymorphism 0.182 0.139 0.11 36 0.245 Q9UM47 R110C Disease NA 0.241 0.18 44 0.379 Q9UM47 R133C Disease NA 0.224 0.05 38 0.391 Q9UM47 R141C Disease NA 0.161 0.03 39 0.297 Q9UM47 R153C Disease NA 0.745 0.05 33 0.775 Q9UM47 R169C Disease NA 0.645 0.01 25 0.411 Q9UM47 R182C Disease NA 0.492 0.01 51 0.783 Q9UM47 R207C Disease NA 0.375 0.06 40 0.430 Q9UM47 R213K Disease 0.218 0.567 0.44 24 0.186 Q9UM47 R332C Disease NA 0.175 0.10 61 0.404 Q9UM47 R421C Disease 0.727 0.400 0.05 59 0.627 Q9UM47 R449C Disease 0.630 0.304 0.05 48 0.609 Q9UM47 R544C Disease 0.424 0.306 0.07 40 0.457 Q9UM47 R558C Disease 0.515 0.338 0.06 49 0.620 Q9UM47 R578C Disease 0.486 0.341 0.18 64 0.656 Q9UM47 R607C Disease 0.602 0.294 0.18 58 0.555 Q9UM47 R728C Disease NA 0.295 0.02 47 0.490 Q9UM47 R985C Disease NA 0.172 0.06 42 0.388 Q9UM47 S118C Disease NA 0.184 0.01 29 0.380 Q9UM47 S145C Disease NA 0.585 0.05 19 0.699 Q9UM47 S180C Disease NA 0.500 0.05 44 0.800 Q9UM47 S335C Disease NA 0.213 0.03 23 0.387 Q9UM47 Y150C Disease NA 0.796 0.01 60 0.979 Q9UM47 Y189C Disease NA 0.473 0.01 64 0.763 Q9UM47 Y258C Disease 0.826 0.248 0.00 54 0.695 Q9UM47 Y337C Disease NA 0.151 0.17 37 0.308 Q9UM47 A1020P Polymorphism NA 0.408 0.21 21 0.334 Q9UM47 C1015R Disease NA 0.625 0.00 79 0.966 Q9UM47 C1261R Disease NA 0.780 0.00 80 0.950 Q9UM47 C1261Y Disease NA 0.806 0.00 74 0.954 Q9UM47 D1063C Disease NA 0.432 0.01 55 0.706 Q9UM47 H1133Q Polymorphism NA 0.303 0.02 53 0.581 Q9UM47 R1006C Disease NA 0.195 0.04 26 0.365 Q9UM47 R1031C Disease NA 0.364 0.19 31 0.386 Q9UM47 R1231C Disease NA 0.509 0.16 30 0.763 Q9UM47 Y1021C Disease NA 0.363 0.17 27 0.387 Q9UM54 C442Y Disease 0.606 0.561 0.03 17 0.724 Q9UM54 E216V Disease NA 0.190 0.11 14 0.236 Q9UM54 H246R Disease 0.718 0.906 0.00 70 0.876 Q9UM73 S90L Polymorphism NA 0.345 NA 30 0.278 Q9UM73 A704T Polymorphism 0.102 0.457 0.00 42 0.262 Q9UM73 V163L Polymorphism NA 0.233 NA 25 0.126 Q9UM73 V476A Polymorphism 0.151 0.087 NA -29 0.033 Q9UM73 D1529E Polymorphism NA 0.074 0.00 11 0.104 Q9UM73 E1419K Polymorphism 0.156 0.527 0.02 33 0.344 Q9UM73 F1376S Polymorphism 0.871 0.876 0.00 44 0.881 Q9UM73 G1121D Polymorphism 0.442 0.778 0.18 -6 0.407 Q9UM73 K1416N Polymorphism 0.213 0.166 0.01 -7 0.172 Q9UM73 M1328L Polymorphism 0.181 0.613 0.02 24 0.408 Q9UM73 P1599H Polymorphism NA 0.382 NA 36 0.294 Q9UM73 T1012M Polymorphism NA 0.137 0.10 -6 0.105 Q9UM82 L443F Polymorphism 0.381 0.034 NA 13 0.049 Q9UMD9 T4A Polymorphism NA 0.182 0.00 19 0.264 Q9UMD9 G428S Polymorphism NA 0.111 0.11 -31 0.072 Q9UMD9 G627V Disease 0.999 0.865 0.00 64 0.992 Q9UMD9 G633D Disease 0.993 0.847 0.00 66 0.998 Q9UMD9 M238T Polymorphism NA 0.366 0.02 27 0.429 Q9UMD9 S265C Disease NA 0.182 0.00 20 0.217 Q9UMD9 T210M Polymorphism NA 0.178 0.00 32 0.352 Q9UMD9 R1303Q Disease NA 0.287 0.54 45 0.320 Q9UMF0 A348T Polymorphism 0.081 0.286 0.13 25 0.230 Q9UMN6 P587R Polymorphism NA 0.187 0.22 40 0.253 Q9UMN6 P754L Polymorphism NA 0.191 0.12 20 0.166 Q9UMN6 P1097L Polymorphism NA 0.216 0.09 19 0.372 Q9UMN6 P1829L Polymorphism NA 0.170 0.00 40 0.188 Q9UMQ6 I521V Polymorphism 0.146 0.383 1.00 9 0.259 Q9UMQ6 S544R Polymorphism 0.497 0.248 0.41 33 0.387 Q9UMQ6 S728N Polymorphism 0.057 0.235 1.00 -29 0.189 Q9UMQ6 V266M Polymorphism 0.211 0.355 0.07 -48 0.204 Q9UMR3 I152M Disease 0.506 0.813 0.18 -40 0.490 Q9UMR5 A34E Polymorphism 0.128 0.222 1.00 24 0.185 Q9UMR7 H36L Polymorphism NA 0.147 0.62 44 0.248 Q9UMS0 M25K Polymorphism 0.120 0.207 NA 47 0.276 Q9UMS6 G154A Polymorphism NA 0.070 0.46 -35 0.034 Q9UMS6 Q174H Polymorphism NA 0.083 0.00 44 0.162 Q9UMS6 T573A Polymorphism 0.108 0.038 0.76 11 0.025 Q9UMW8 T169M Polymorphism 0.119 0.271 0.12 -4 0.242 Q9UMX1 P15L Polymorphism 0.248 0.165 NA -8 0.082 Q9UMX1 A340S Polymorphism 0.102 0.088 NA 20 0.081 Q9UMX9 P58A Disease 0.963 0.882 0.00 -11 0.904 Q9UMX9 P58S Disease 0.970 0.900 0.00 -11 0.917 Q9UMX9 A477T Disease 0.525 0.537 0.05 44 0.772 Q9UMX9 A486V Disease 0.835 0.500 0.10 20 0.742 Q9UMX9 D157N Disease 0.598 0.695 0.45 13 0.490 Q9UMX9 G188V Disease 0.977 0.940 0.03 28 0.936 Q9UMX9 L361P Disease 0.569 0.920 0.21 46 0.866 Q9UMX9 T500P Polymorphism 0.329 0.510 0.11 26 0.584 Q9UMX9 V507L Polymorphism 0.415 0.593 0.15 6 0.626 Q9UMX9 W202C Disease 0.992 0.870 0.00 65 0.943 Q9UMX9 Y317C Disease 0.624 0.604 0.01 51 0.838 Q9UMZ3 I1734T Polymorphism NA 0.420 0.02 46 0.350 Q9UMZ3 T1040I Polymorphism 0.385 0.159 0.11 33 0.307 Q9UN36 T45S Polymorphism 0.839 0.903 0.00 43 0.894 Q9UN66 E232G Polymorphism 0.412 0.543 0.36 20 0.705 Q9UN66 E244Q Polymorphism 0.170 0.461 0.35 -14 0.247 Q9UN66 F767L Polymorphism 0.418 0.776 0.00 38 0.633 Q9UN66 G759V Polymorphism 0.600 0.491 0.01 29 0.614 Q9UN66 I382T Polymorphism 0.178 0.444 0.18 15 0.193 Q9UN66 K199N Polymorphism 0.376 0.592 0.02 19 0.510 Q9UN66 K305E Polymorphism 0.264 0.522 1.00 36 0.342 Q9UN66 S745N Polymorphism 0.406 0.309 0.02 18 0.456 Q9UN72 A663G Polymorphism 0.722 0.487 0.01 32 0.743 Q9UN72 R138K Polymorphism 0.409 0.615 0.44 -9 0.155 Q9UN74 E55D Polymorphism 0.320 0.370 0.37 -32 0.285 Q9UN88 L15I Polymorphism NA 0.327 0.02 -40 0.211 Q9UN88 F478I Polymorphism NA 0.058 0.01 -8 0.027 Q9UNA0 R614H Polymorphism 0.502 0.583 0.01 26 0.586 Q9UNA1 N417S Disease 0.129 0.241 0.98 12 0.226 Q9UND3 R93C Polymorphism 0.525 0.427 0.16 -3 0.411 Q9UNE0 C87R Disease NA 0.770 0.03 74 0.875 Q9UNE0 R89H Disease NA 0.468 0.12 39 0.585 Q9UNE0 R420Q Disease NA 0.432 0.00 52 0.494 Q9UNF0 M294I Polymorphism 0.539 0.863 0.32 40 0.850 Q9UNF0 V324F Polymorphism NA 0.638 0.04 45 0.674 Q9UNF1 Q266R Polymorphism 0.186 0.286 0.05 15 0.251 Q9UNH5 R345Q Polymorphism 0.273 0.065 0.54 -5 0.101 Q9UNH6 F186L Polymorphism 0.573 0.872 0.00 9 0.629 Q9UNH6 S278N Polymorphism 0.374 0.342 0.13 13 0.392 Q9UNI1 M59V Polymorphism 0.275 0.201 0.45 7 0.183 Q9UNI1 Q243R Polymorphism 0.313 0.127 1.00 -2 0.087 Q9UNK4 H96R Polymorphism 0.079 0.279 0.21 11 0.180 Q9UNK4 R121L Polymorphism 0.213 0.462 0.11 31 0.459 Q9UNK9 G141W Polymorphism NA 0.251 0.00 43 0.152 Q9UNM6 L205F Polymorphism 0.746 0.778 0.02 33 0.733 Q9UNN8 S219G Polymorphism 0.184 0.335 0.21 7 0.173 Q9UNQ0 V12M Polymorphism 0.060 0.172 1.00 -27 0.061 Q9UNQ0 D296H Polymorphism 0.781 0.797 0.14 36 0.748 Q9UNQ0 D620N Polymorphism 0.220 0.392 1.00 -8 0.268 Q9UNQ0 F431L Polymorphism 0.123 0.951 0.02 34 0.512 Q9UNQ0 Q141K Polymorphism 0.119 0.578 0.93 -14 0.060 Q9UNQ0 Q166E Polymorphism 0.086 0.667 0.74 -37 0.041 Q9UNQ0 S248P Polymorphism 0.461 0.872 0.15 44 0.833 Q9UNS1 A129S Polymorphism NA 0.064 0.65 -4 0.094 Q9UNS1 M870V Polymorphism 0.247 0.235 0.00 38 0.323 Q9UNS1 R924W Polymorphism 0.811 0.290 0.00 42 0.584 Q9UNS1 I1017T Polymorphism 0.153 0.071 0.32 -18 0.039 Q9UNS1 P1018L Polymorphism 0.091 0.216 0.00 -3 0.282 Q9UNU6 R234H Polymorphism 0.644 0.525 0.11 29 0.562 Q9UNX4 P234A Polymorphism NA 0.144 0.75 -10 0.195 Q9UNY4 K167E Polymorphism NA 0.233 0.01 2 0.179 Q9UNZ2 D290N Polymorphism 0.076 0.390 0.39 27 0.258 Q9UNZ5 K39R Polymorphism NA 0.172 0.00 35 0.325 Q9UP38 V343M Polymorphism 0.622 0.563 0.01 4 0.632 Q9UP52 V22I Disease NA 0.052 0.77 -15 0.012 Q9UP52 M172K Disease 0.130 0.500 0.10 39 0.423 Q9UP52 Q690P Disease 0.259 0.735 0.17 18 0.626 Q9UP65 A38P Polymorphism 0.220 0.299 0.33 -44 0.171 Q9UP65 D411N Polymorphism 0.630 0.568 0.13 41 0.543 Q9UP65 T226S Polymorphism 0.291 0.213 0.35 -25 0.174 Q9UPA5 A741T Polymorphism 0.315 0.026 0.43 18 0.070 Q9UPA5 A3863T Polymorphism NA 0.045 0.24 -26 0.013 Q9UPA5 G1213D Polymorphism 0.549 0.286 0.22 7 0.516 Q9UPI3 V16A Polymorphism NA 0.074 0.49 -30 0.011 Q9UPN9 V961M Polymorphism 0.239 0.115 0.07 -23 0.232 Q9UPN9 P1090T Polymorphism NA 0.155 0.23 -14 0.184 Q9UPQ3 D148G Polymorphism 0.413 0.746 0.00 28 0.732 Q9UPQ3 V671I Polymorphism NA 0.154 0.04 -10 0.201 Q9UPQ7 A783V Polymorphism 0.167 0.083 0.21 -18 0.076 Q9UPQ8 C99S Disease 0.254 0.485 NA 32 0.555 Q9UPQ8 Y441S Disease 0.114 0.534 NA 22 0.381 Q9UPR0 A742V Polymorphism 0.163 0.769 0.09 7 0.357 Q9UPR0 H890R Polymorphism NA 0.244 0.13 12 0.341 Q9UPR0 P809H Polymorphism 0.227 0.900 0.00 70 0.921 Q9UPR3 N1004D Polymorphism 0.151 0.161 NA 23 0.163 Q9UPR5 V429L Polymorphism 0.296 0.964 0.08 51 0.637 Q9UPR6 D589N Polymorphism 0.338 0.751 0.04 29 0.678 Q9UPR6 P235L Polymorphism NA 0.196 0.48 -38 0.294 Q9UPR6 S164L Polymorphism NA 0.196 0.14 28 0.340 Q9UPS8 V1304I Polymorphism NA 0.056 0.80 -33 0.068 Q9UPT6 T753A Polymorphism 0.134 0.149 0.69 -19 0.196 Q9UPT8 E287K Polymorphism NA 0.116 0.02 -7 0.166 Q9UPT8 A1228G Polymorphism 0.352 0.158 0.39 -29 0.155 Q9UPU5 G1940S Polymorphism NA 0.326 0.26 15 0.334 Q9UPU5 V2468A Polymorphism NA 0.181 0.44 19 0.086 Q9UPV0 S94N Polymorphism NA 0.058 NA 7 0.014 Q9UPV0 Q1119R Polymorphism NA 0.020 0.04 12 0.047 Q9UPW6 S263P Polymorphism 0.323 0.248 0.25 -24 0.199 Q9UPX6 I832V Polymorphism NA 0.235 0.00 -4 0.195 Q9UPZ3 L417M Polymorphism 0.563 0.200 0.00 26 0.193 Q9UPZ6 D771E Polymorphism 0.302 0.358 0.98 36 0.346 Q9UPZ6 F238L Polymorphism NA 0.093 0.80 2 0.127 Q9UPZ9 A615T Polymorphism NA 0.092 0.16 19 0.097 Q9UPZ9 R272Q Disease NA 0.915 0.00 75 0.925 Q9UPZ9 R476Q Polymorphism NA 0.068 0.19 13 0.045 Q9UPZ9 T471K Polymorphism NA 0.102 0.41 41 0.089 Q9UPZ9 V320I Polymorphism NA 0.178 0.19 -15 0.100 Q9UQ03 L238V Polymorphism 0.354 0.680 0.12 -19 0.502 Q9UQ07 D86N Polymorphism 0.344 0.530 0.03 30 0.558 Q9UQ07 K230R Polymorphism NA 0.130 0.31 -25 0.191 Q9UQ07 P248S Polymorphism NA 0.117 0.42 -57 0.170 Q9UQ07 Q398R Polymorphism NA 0.185 0.53 40 0.161 Q9UQ10 A2P Polymorphism NA 0.848 0.00 -36 0.742 Q9UQ10 S66N Polymorphism 0.290 0.210 0.52 -32 0.132 Q9UQ10 V200M Polymorphism 0.579 0.195 0.14 -5 0.338 Q9UQ10 V247A Polymorphism 0.201 0.274 1.00 -7 0.159 Q9UQ13 S2G Disease NA 0.120 0.00 12 0.262 Q9UQ35 P804T Polymorphism NA 0.060 0.60 5 0.045 Q9UQ49 R15Q Polymorphism NA 0.023 1.00 -36 0.015 Q9UQ52 F150S Polymorphism 0.516 0.522 0.05 2 0.173 Q9UQ72 A176T Polymorphism 0.213 0.246 0.86 -11 0.203 Q9UQ84 R93G Polymorphism 0.688 0.749 0.09 47 0.842 Q9UQ84 V27A Polymorphism 0.735 0.859 0.03 34 0.801 Q9UQ84 A137S Polymorphism 0.489 0.358 0.39 16 0.512 Q9UQ84 D428N Polymorphism 0.370 0.244 0.28 -19 0.387 Q9UQ84 E589K Polymorphism 0.122 0.125 0.67 25 0.078 Q9UQ84 F438C Polymorphism 0.570 0.146 0.11 19 0.154 Q9UQ84 H726P Polymorphism 0.635 0.115 0.21 27 0.090 Q9UQ84 N279S Polymorphism 0.395 0.410 0.74 3 0.413 Q9UQ84 N299S Polymorphism 0.359 0.307 1.00 1 0.263 Q9UQ84 P757L Polymorphism 0.157 0.248 0.12 0 0.316 Q9UQ84 R634Q Polymorphism 0.218 0.093 0.40 -1 0.101 Q9UQ84 S610G Polymorphism 0.532 0.164 0.25 41 0.178 Q9UQ84 V458M Polymorphism 0.289 0.056 0.26 -12 0.023 Q9UQ84 V460L Polymorphism 0.373 0.043 0.39 0 0.075 Q9UQ88 C57R Polymorphism NA 0.222 0.14 21 0.099 Q9UQ88 R93W Polymorphism NA 0.255 0.01 20 0.206 Q9UQ90 F623C Polymorphism 0.830 0.467 0.18 23 0.695 Q9UQ90 N730D Polymorphism 0.128 0.311 0.94 -48 0.129 Q9UQ90 S692T Disease 0.413 0.774 0.01 57 0.840 Q9UQ90 T503A Polymorphism 0.088 0.200 0.28 0 0.213 Q9UQB8 Q519R Polymorphism 0.136 0.059 0.17 15 0.028 Q9UQC2 P344L Polymorphism 0.280 0.130 1.00 19 0.107 Q9UQC9 V80I Polymorphism 0.354 0.171 0.52 -28 0.248 Q9UQC9 G534D Polymorphism 0.184 0.150 0.57 1 0.122 Q9UQC9 Q306E Polymorphism 0.312 0.714 0.05 19 0.672 Q9UQF0 S307N Polymorphism 0.087 0.201 0.78 13 0.171 Q9UQF0 S477F Polymorphism 0.370 0.633 0.01 28 0.699 Q9UQF0 V129A Polymorphism 0.302 0.129 0.04 22 0.151 Q9UQF2 S59N Disease NA 0.149 0.06 23 0.156 Q9UQF2 A322V Polymorphism NA 0.135 0.00 -3 0.147 Q9UQL6 G565A Polymorphism NA 0.152 1.00 -7 0.136 Q9UQL6 R137Q Polymorphism NA 0.135 0.79 -12 0.099 Q9UQN3 I29V Polymorphism 0.164 0.114 0.04 -3 0.152 Q9UQN3 D148Y Disease 0.787 0.773 0.01 43 0.846 Q9UQP3 M859V Polymorphism 0.164 0.365 0.41 15 0.032 Q9UQP3 R440S Polymorphism NA 0.265 0.79 40 0.285 Q9UQP3 T499M Polymorphism NA 0.360 0.11 -4 0.385 Q9UQP3 T941M Polymorphism 0.671 0.329 0.12 54 0.657 Q9UQP3 D1135E Polymorphism 0.078 0.500 0.03 30 0.166 Q9UQQ1 Q2H Polymorphism NA 0.105 0.32 -45 0.075 Q9UQQ1 K398T Polymorphism 0.519 0.727 0.06 0 0.566 Q9UQQ2 W262R Polymorphism 0.049 0.094 0.16 8 0.074 Q9UQV4 E32G Polymorphism 0.170 0.122 0.18 18 0.093 Q9Y210 E897K Disease NA 0.908 0.00 34 0.856 Q9Y210 N143S Disease 0.450 0.792 0.04 29 0.643 Q9Y210 N157T Polymorphism 0.529 0.239 0.53 24 0.522 Q9Y210 P112Q Disease 0.837 0.579 0.06 -21 0.752 Q9Y210 R895C Disease NA 0.971 0.00 60 0.920 Q9Y210 S270T Disease 0.912 0.869 0.00 32 0.816 Q9Y215 P59Q Disease 0.623 0.272 0.02 21 0.458 Q9Y215 C444Y Disease 0.540 0.638 0.00 38 0.723 Q9Y215 D342E Disease 0.215 0.316 0.12 36 0.243 Q9Y215 R410Q Disease 0.268 0.157 0.11 -3 0.068 Q9Y215 Y430S Disease 0.362 0.453 0.00 20 0.300 Q9Y217 A131T Polymorphism 0.176 0.204 0.73 -10 0.174 Q9Y219 E501K Polymorphism 0.085 0.290 0.55 40 0.296 Q9Y222 V479I Polymorphism 0.013 0.159 0.27 31 0.122 Q9Y223 P27S Disease NA 0.267 0.03 -47 0.263 Q9Y223 P36L Disease NA 0.254 0.04 -4 0.285 Q9Y223 A460V Disease NA 0.152 0.49 20 0.150 Q9Y223 A524V Disease 0.354 0.733 0.02 42 0.724 Q9Y223 A600T Disease 0.322 0.474 0.18 38 0.452 Q9Y223 A630T Disease 0.322 0.689 0.07 32 0.543 Q9Y223 A631T Disease 0.322 0.849 0.00 41 0.659 Q9Y223 A631V Disease 0.354 0.836 0.00 40 0.709 Q9Y223 C303V Disease NA 0.418 0.16 -8 0.189 Q9Y223 D176V Disease NA 0.251 0.05 -3 0.366 Q9Y223 D225N Disease NA 0.334 0.48 -9 0.215 Q9Y223 D378Y Disease NA 0.555 0.01 51 0.727 Q9Y223 F528C Disease 0.741 0.839 0.02 62 0.861 Q9Y223 G206S Disease NA 0.383 0.48 -1 0.257 Q9Y223 G576E Disease 0.549 0.910 0.03 57 0.859 Q9Y223 H132Q Disease NA 0.939 0.00 59 0.930 Q9Y223 I200F Disease NA 0.276 0.24 21 0.349 Q9Y223 I472T Disease NA 0.543 0.02 57 0.756 Q9Y223 I557T Disease 0.413 0.473 0.32 52 0.694 Q9Y223 I587T Disease 0.413 0.436 0.04 47 0.576 Q9Y223 M171V Disease NA 0.562 0.23 24 0.753 Q9Y223 M712T Disease 0.292 0.327 0.01 34 0.488 Q9Y223 N519S Disease 0.324 0.814 0.00 47 0.736 Q9Y223 R162C Disease NA 0.722 0.03 13 0.746 Q9Y223 R177C Disease NA 0.895 0.01 1 0.623 Q9Y223 R246Q Disease NA 0.125 0.38 -30 0.149 Q9Y223 R246W Disease NA 0.584 0.02 27 0.749 Q9Y223 R263L Disease NA 0.239 0.14 -24 0.342 Q9Y223 R266Q Disease NA 0.162 0.34 -4 0.189 Q9Y223 R266W Disease NA 0.641 0.02 34 0.766 Q9Y223 R306Q Disease NA 0.327 0.38 0 0.430 Q9Y223 V216A Disease NA 0.289 0.08 -1 0.368 Q9Y223 V331A Disease NA 0.707 0.18 25 0.778 Q9Y223 V572L Disease 0.209 0.554 0.09 46 0.461 Q9Y223 V696M Disease 0.369 0.237 0.02 30 0.377 Q9Y223 Y675H Disease 0.502 0.454 0.37 47 0.582 Q9Y226 V43I Polymorphism NA 0.099 0.15 -39 0.121 Q9Y228 Q373E Polymorphism NA 0.032 1.00 -33 0.011 Q9Y231 W358G Polymorphism 0.783 0.409 0.00 22 0.654 Q9Y232 V48A Polymorphism NA 0.077 0.00 41 0.148 Q9Y233 L303P Polymorphism NA 0.914 0.03 14 0.777 Q9Y238 S192F Polymorphism 0.259 0.059 0.38 -30 0.020 Q9Y238 K1022N Polymorphism 0.326 0.073 0.18 23 0.060 Q9Y238 N1150D Polymorphism 0.457 0.037 0.10 -23 0.025 Q9Y239 R605W Polymorphism 0.832 0.683 0.02 42 0.808 Q9Y242 P109S Polymorphism 0.073 0.051 0.10 16 0.051 Q9Y242 P241L Polymorphism 0.335 0.072 0.08 28 0.064 Q9Y250 S50F Polymorphism NA 0.229 0.02 24 0.409 Q9Y250 L475V Polymorphism NA 0.065 0.64 -16 0.080 Q9Y252 S623N Polymorphism NA 0.077 0.30 -5 0.096 Q9Y252 V203E Polymorphism 0.457 0.249 0.34 12 0.138 Q9Y253 G209V Polymorphism 0.326 0.885 0.02 37 0.740 Q9Y253 G263V Disease 0.900 0.635 0.29 7 0.846 Q9Y253 K535E Disease NA 0.150 0.10 23 0.142 Q9Y253 K589T Disease NA 0.088 0.00 7 0.141 Q9Y253 L584P Polymorphism NA 0.117 0.08 0 0.116 Q9Y253 M595V Polymorphism NA 0.113 0.01 -2 0.115 Q9Y253 M647L Polymorphism NA 0.158 0.86 -11 0.095 Q9Y253 R111H Disease 0.639 0.769 0.39 43 0.850 Q9Y253 R334W Polymorphism NA 0.466 0.20 14 0.431 Q9Y253 R361S Disease 0.476 0.537 0.14 56 0.657 Q9Y253 T122P Disease 0.713 0.927 0.01 61 0.933 Q9Y253 T478M Polymorphism NA 0.129 0.02 37 0.158 Q9Y257 V240I Polymorphism 0.114 0.165 1.00 -18 0.101 Q9Y257 V259M Polymorphism NA 0.293 0.19 -22 0.262 Q9Y264 E395K Polymorphism 0.369 0.487 0.20 21 0.316 Q9Y267 I144T Polymorphism 0.064 0.481 1.00 37 0.086 Q9Y267 K112E Polymorphism 0.301 0.306 0.57 -14 0.178 Q9Y267 L466P Polymorphism NA 0.584 0.19 27 0.751 Q9Y267 P560R Polymorphism 0.725 0.872 0.00 56 0.867 Q9Y267 S245L Polymorphism 0.423 0.709 0.00 -4 0.504 Q9Y267 S292G Polymorphism 0.400 0.099 0.54 16 0.182 Q9Y276 G35R Disease 0.450 0.658 0.03 48 0.757 Q9Y276 P99L Disease 0.686 0.948 0.00 56 0.873 Q9Y276 R45C Disease 0.863 0.940 0.00 56 0.948 Q9Y276 S78G Disease 0.536 0.748 0.03 30 0.621 Q9Y276 Q302E Disease 0.150 0.712 1.00 -10 0.151 Q9Y276 R114W Disease 0.737 0.794 0.08 3 0.599 Q9Y276 R144Q Disease 0.316 0.509 0.07 34 0.553 Q9Y276 R155P Disease 0.613 0.920 0.24 67 0.922 Q9Y276 R183H Disease 0.624 0.363 0.02 43 0.633 Q9Y276 R184C Disease NA 0.345 0.06 22 0.454 Q9Y276 R306H Disease 0.612 0.700 0.07 6 0.598 Q9Y276 S277N Disease 0.727 0.644 0.09 41 0.819 Q9Y276 V327A Disease 0.255 0.388 0.00 34 0.448 Q9Y276 V353M Disease 0.514 0.072 0.00 0 0.223 Q9Y279 R108W Polymorphism 0.816 0.437 0.02 54 0.646 Q9Y281 A35T Disease 0.277 0.125 0.22 -17 0.240 Q9Y282 I113L Polymorphism 0.206 0.233 0.31 -1 0.170 Q9Y283 L493S Disease 0.648 0.485 0.00 49 0.803 Q9Y283 P482R Disease 0.702 0.205 0.13 36 0.491 Q9Y283 S242L Polymorphism 0.555 0.211 0.06 3 0.457 Q9Y283 S888R Polymorphism NA 0.129 0.10 38 0.120 Q9Y289 S481F Polymorphism NA 0.202 0.03 37 0.342 Q9Y297 P592H Polymorphism 0.120 0.254 0.02 36 0.313 Q9Y2A4 P591Q Polymorphism 0.444 0.602 0.53 -10 0.154 Q9Y2B4 H219Q Polymorphism NA 0.330 NA 62 0.440 Q9Y2B4 P221L Polymorphism NA 0.361 NA 48 0.541 Q9Y2B4 R191H Polymorphism NA 0.067 NA -23 0.021 Q9Y2B4 V172A Polymorphism NA 0.031 NA -26 0.010 Q9Y2B4 V257A Polymorphism NA 0.195 NA 49 0.075 Q9Y2C3 M85T Polymorphism NA 0.308 0.39 -16 0.159 Q9Y2C3 S27R Polymorphism NA 0.169 0.06 4 0.248 Q9Y2C4 G277V Polymorphism 0.702 0.892 0.01 68 0.928 Q9Y2C5 A372T Polymorphism 0.189 0.192 0.58 -37 0.157 Q9Y2C9 R247K Polymorphism NA 0.405 0.87 -17 0.241 Q9Y2C9 V327M Polymorphism NA 0.220 0.05 19 0.366 Q9Y2C9 V465I Polymorphism 0.082 0.050 1.00 -6 0.030 Q9Y2D8 C578R Polymorphism 0.138 0.278 0.25 33 0.195 Q9Y2F5 G1058D Polymorphism NA 0.122 NA 41 0.111 Q9Y2F5 P1618L Polymorphism NA 0.050 0.03 27 0.063 Q9Y2F5 Q1597P Polymorphism NA 0.049 0.01 -6 0.037 Q9Y2F5 T1054A Polymorphism NA 0.050 NA 10 0.045 Q9Y2G1 A723T Polymorphism 0.398 0.125 NA -32 0.109 Q9Y2G4 A550T Polymorphism 0.180 0.049 NA 13 0.039 Q9Y2G4 Q122E Polymorphism 0.298 0.234 0.73 41 0.288 Q9Y2G4 T233M Polymorphism 0.439 0.208 0.11 -16 0.225 Q9Y2H0 R861Q Polymorphism 0.655 0.205 0.37 1 0.353 Q9Y2H2 I453V Polymorphism 0.187 0.239 0.46 -8 0.250 Q9Y2H2 N997D Polymorphism NA 0.223 0.53 -29 0.111 Q9Y2H8 G634E Polymorphism 0.835 0.858 0.04 55 0.826 Q9Y2H9 A1048S Polymorphism NA 0.125 0.76 -16 0.125 Q9Y2H9 P1292S Polymorphism NA 0.071 0.58 -38 0.063 Q9Y2I1 A1056V Polymorphism 0.064 0.092 NA 14 0.051 Q9Y2I6 G79V Polymorphism 0.468 0.195 0.05 39 0.400 Q9Y2I6 E973K Polymorphism 0.126 0.163 0.46 38 0.144 Q9Y2I6 R276W Polymorphism 0.760 0.199 0.03 31 0.331 Q9Y2I6 T296A Polymorphism 0.663 0.299 0.00 42 0.524 Q9Y2I7 K1103R Disease NA 0.184 0.57 11 0.138 Q9Y2I7 S1033A Polymorphism NA 0.192 NA 3 0.167 Q9Y2I8 I225V Polymorphism 0.274 0.221 0.29 9 0.314 Q9Y2I9 N596D Polymorphism 0.125 0.135 0.05 -13 0.109 Q9Y2I9 N759D Polymorphism 0.099 0.189 0.03 -7 0.153 Q9Y2I9 V752I Polymorphism 0.124 0.099 0.04 -51 0.062 Q9Y2J2 E859Q Polymorphism 0.543 0.220 0.11 20 0.395 Q9Y2J4 A342P Polymorphism 0.527 0.459 0.39 49 0.602 Q9Y2K3 D1467N Polymorphism 0.230 0.540 0.00 17 0.502 Q9Y2K3 T1125A Polymorphism 0.429 0.113 1.00 -83 0.100 Q9Y2K6 S103Y Polymorphism 0.467 0.107 1.00 46 0.258 Q9Y2K9 V855I Polymorphism 0.203 0.216 0.08 -27 0.231 Q9Y2L1 T326R Polymorphism 0.099 0.378 0.53 1 0.184 Q9Y2L5 S517G Polymorphism 0.299 0.099 0.24 -43 0.124 Q9Y2L5 I1189V Polymorphism 0.141 0.051 NA -25 0.080 Q9Y2L5 S1298P Polymorphism 0.407 0.060 NA -33 0.064 Q9Y2L9 A486S Polymorphism 0.093 0.182 0.10 37 0.197 Q9Y2N7 Q343R Polymorphism 0.080 0.133 0.22 20 0.122 Q9Y2P5 M50T Polymorphism NA 0.149 0.06 -20 0.055 Q9Y2P5 R53W Polymorphism NA 0.119 0.02 -7 0.071 Q9Y2Q9 R103W Polymorphism 0.889 0.224 NA 46 0.566 Q9Y2R2 R620W Polymorphism NA 0.188 0.00 40 0.281 Q9Y2T7 S63P Polymorphism 0.043 0.061 0.25 15 0.030 Q9Y2U5 D140G Polymorphism NA 0.126 NA 16 0.127 Q9Y2U5 I110V Polymorphism NA 0.091 0.39 -12 0.074 Q9Y2U8 D260Y Polymorphism NA 0.290 NA 31 0.217 Q9Y2V3 R192Q Disease 0.700 0.917 0.00 65 0.924 Q9Y2V7 C32S Polymorphism NA 0.096 0.97 -2 0.038 Q9Y2V7 H300Y Polymorphism 0.489 0.722 0.14 32 0.580 Q9Y2W1 A201V Polymorphism 0.084 0.048 0.09 10 0.042 Q9Y2W6 G257A Polymorphism 0.414 0.079 0.76 -28 0.077 Q9Y2W7 A119V Polymorphism 0.162 0.664 0.22 5 0.208 Q9Y2X0 L770F Polymorphism 0.336 0.033 0.07 9 0.071 Q9Y2X3 A389P Polymorphism 0.655 0.903 0.24 10 0.841 Q9Y2X3 N387T Polymorphism 0.307 0.385 0.41 -8 0.393 Q9Y2Y1 S24A Polymorphism 0.116 0.143 1.00 19 0.098 Q9Y2Y6 W83R Polymorphism NA 0.731 0.00 64 0.904 Q9Y2Z4 G191V Polymorphism 0.545 0.731 0.01 -23 0.486 Q9Y2Z9 D300Y Polymorphism 0.517 0.750 0.03 46 0.843 Q9Y2Z9 T395M Polymorphism NA 0.519 0.12 2 0.541 Q9Y2Z9 V406M Polymorphism NA 0.648 0.23 -50 0.368 Q9Y334 G704V Polymorphism 0.653 0.735 0.00 48 0.860 Q9Y334 R488Q Polymorphism 0.104 0.037 0.53 -25 0.064 Q9Y336 A315E Polymorphism 0.319 0.191 1.00 -8 0.154 Q9Y336 A316D Polymorphism 0.185 0.759 0.00 52 0.662 Q9Y336 K100E Polymorphism 0.315 0.500 0.27 10 0.482 Q9Y336 V349A Polymorphism 0.250 0.049 0.64 -49 0.063 Q9Y337 G55R Polymorphism 0.362 0.201 0.04 43 0.311 Q9Y345 A132G Polymorphism NA 0.072 0.26 5 0.041 Q9Y345 D463N Polymorphism 0.143 0.286 0.57 -20 0.219 Q9Y345 L306V Disease 0.671 0.827 0.04 7 0.576 Q9Y345 N509S Disease 0.978 0.822 0.01 39 0.880 Q9Y345 Q184R Polymorphism 0.096 0.210 0.42 -4 0.158 Q9Y345 S510R Disease 0.359 0.728 0.32 17 0.580 Q9Y345 T425M Disease 0.924 0.833 0.05 21 0.825 Q9Y345 W482C Disease 0.926 0.625 0.05 6 0.752 Q9Y345 Y491C Disease 0.993 0.870 0.00 55 0.941 Q9Y375 R9H Polymorphism 0.267 0.054 0.11 0 0.066 Q9Y375 A314G Polymorphism 0.576 0.450 0.00 39 0.631 Q9Y383 D361E Polymorphism 0.065 0.123 0.19 -2 0.167 Q9Y388 R287H Polymorphism 0.343 0.141 0.29 50 0.121 Q9Y399 M158V Polymorphism 0.297 0.148 0.20 4 0.267 Q9Y3A0 R20Q Polymorphism 0.152 0.036 0.49 9 0.046 Q9Y3A4 L75M Polymorphism 0.635 0.448 0.00 -18 0.492 Q9Y3A4 V88I Polymorphism 0.440 0.302 0.74 -11 0.220 Q9Y3A5 N8K Disease NA 0.875 0.12 36 0.828 Q9Y3A5 E44G Disease 0.720 0.845 0.04 32 0.868 Q9Y3A5 I87S Disease 0.881 0.905 0.00 38 0.892 Q9Y3A5 K67E Disease 0.337 0.446 0.36 13 0.490 Q9Y3A5 I212T Disease 0.517 0.604 0.01 51 0.697 Q9Y3A5 R126T Disease 0.499 0.751 0.26 38 0.591 Q9Y3A5 R169C Disease 0.820 0.817 0.03 57 0.923 Q9Y3A6 T175I Polymorphism 0.534 0.331 0.02 7 0.574 Q9Y3B6 A97V Polymorphism 0.356 0.619 0.00 46 0.684 Q9Y3B9 A32V Polymorphism 0.095 0.182 0.73 -15 0.126 Q9Y3B9 K230R Polymorphism 0.114 0.050 0.36 3 0.082 Q9Y3C5 D11E Polymorphism 0.336 0.229 0.00 34 0.342 Q9Y3C6 C36S Polymorphism 0.644 0.456 0.03 8 0.603 Q9Y3D7 Q114K Polymorphism 0.139 0.037 0.78 -11 0.068 Q9Y3E2 G98A Polymorphism 0.198 0.102 0.94 -54 0.089 Q9Y3I0 V153A Polymorphism 0.141 0.665 1.00 -20 0.154 Q9Y3I1 R378G Disease NA 0.823 0.04 54 0.879 Q9Y3L3 P511L Polymorphism 0.377 0.157 0.20 16 0.153 Q9Y3L3 S656F Polymorphism 0.381 0.161 0.70 35 0.086 Q9Y3M8 K250R Polymorphism 0.218 0.199 0.05 -1 0.267 Q9Y3M8 R383P Polymorphism 0.150 0.268 0.25 17 0.195 Q9Y3M8 T175M Polymorphism NA 0.234 0.02 19 0.372 Q9Y3M9 V17I Polymorphism 0.453 0.570 0.03 41 0.606 Q9Y3M9 R467G Polymorphism 0.470 0.286 0.00 36 0.502 Q9Y3N9 D296N Polymorphism 0.573 0.717 0.01 25 0.653 Q9Y3P4 H227R Polymorphism NA 0.148 0.03 22 0.160 Q9Y3Q0 V101I Polymorphism 0.461 0.132 0.46 8 0.247 Q9Y3Q3 D86N Polymorphism 0.638 0.423 0.05 27 0.579 Q9Y3Q4 S672R Disease 0.742 0.369 0.03 45 0.683 Q9Y3R4 R41Q Polymorphism 0.468 0.827 0.00 64 0.908 Q9Y3R4 S11R Polymorphism NA 0.092 0.33 -11 0.058 Q9Y3R4 A145T Polymorphism 0.061 0.392 0.60 -27 0.054 Q9Y3R4 R182Q Polymorphism 0.468 0.180 0.32 34 0.249 Q9Y3R5 G2139E Polymorphism 0.493 0.110 0.26 -10 0.232 Q9Y3R5 R1217S Polymorphism 0.509 0.050 0.22 10 0.083 Q9Y3S2 T28A Polymorphism 0.153 0.030 NA -11 0.072 Q9Y3T6 L403R Polymorphism 0.376 0.695 0.16 37 0.725 Q9Y3T9 A271V Polymorphism 0.396 0.247 0.13 8 0.311 Q9Y3X0 L478P Polymorphism NA 0.060 0.16 1 0.018 Q9Y3Z3 G209S Disease 0.971 0.867 0.00 50 0.945 Q9Y3Z3 H123P Disease 0.838 0.937 0.02 52 0.929 Q9Y3Z3 I201N Disease 0.763 0.734 0.00 27 0.795 Q9Y3Z3 L369S Disease 0.884 0.860 0.00 41 0.888 Q9Y3Z3 M254V Disease 0.249 0.606 0.57 34 0.352 Q9Y3Z3 M385V Disease 0.510 0.910 0.14 50 0.721 Q9Y3Z3 R143C Disease 0.992 0.904 0.00 64 0.951 Q9Y3Z3 R143H Disease 0.984 0.879 0.00 57 0.950 Q9Y3Z3 R145Q Disease 0.779 0.806 0.37 21 0.822 Q9Y426 T618A Polymorphism NA 0.087 NA -24 0.028 Q9Y426 V211A Polymorphism NA 0.087 NA -24 0.024 Q9Y442 H11L Polymorphism NA 0.155 NA 40 0.026 Q9Y448 A40E Polymorphism NA 0.534 NA 52 0.738 Q9Y448 P92S Polymorphism NA 0.045 NA -32 0.031 Q9Y448 R75L Polymorphism NA 0.421 NA 29 0.260 Q9Y458 E187K Polymorphism 0.337 0.781 0.58 -5 0.456 Q9Y458 G118C Disease 0.998 0.946 0.00 65 0.954 Q9Y458 L214P Disease 0.756 0.942 0.00 56 0.923 Q9Y458 M121V Disease 0.153 0.923 0.00 58 0.769 Q9Y458 N264Y Disease 0.995 0.854 0.00 59 0.947 Q9Y458 P183L Disease 0.582 0.901 0.21 33 0.593 Q9Y458 T260M Disease 0.998 0.799 0.00 62 0.949 Q9Y463 R102H Polymorphism 0.369 0.518 0.58 -21 0.423 Q9Y463 S234G Polymorphism 0.198 0.185 0.66 -1 0.141 Q9Y467 S75C Polymorphism NA 0.115 0.00 16 0.159 Q9Y468 S49T Polymorphism NA 0.166 0.00 16 0.230 Q9Y468 I479M Polymorphism 0.516 0.347 0.17 34 0.563 Q9Y485 I221M Polymorphism 0.398 0.077 0.01 10 0.124 Q9Y485 T2107S Polymorphism 0.178 0.038 0.01 -39 0.034 Q9Y485 V2067M Polymorphism 0.701 0.322 0.00 -16 0.572 Q9Y487 R685Q Polymorphism 0.427 0.712 0.39 -31 0.474 Q9Y490 A1984T Polymorphism 0.121 0.120 0.12 -40 0.092 Q9Y490 S1227L Polymorphism 0.205 0.203 0.45 -6 0.306 Q9Y493 G412S Polymorphism 0.046 0.491 0.34 29 0.386 Q9Y493 C1742R Polymorphism 0.958 0.416 0.01 68 0.938 Q9Y493 F1096C Polymorphism 0.371 0.712 0.18 13 0.623 Q9Y493 L1012R Polymorphism 0.065 0.239 0.55 21 0.172 Q9Y493 L1698P Polymorphism 0.146 0.176 0.12 -12 0.186 Q9Y493 N2073S Polymorphism 0.439 0.397 0.02 37 0.452 Q9Y493 P1878S Polymorphism 0.443 0.615 0.43 18 0.469 Q9Y493 T2527M Polymorphism NA 0.266 0.16 25 0.395 Q9Y493 W2643R Polymorphism NA 0.355 0.36 44 0.259 Q9Y4A5 A1925V Polymorphism 0.545 0.262 0.11 8 0.523 Q9Y4A5 S1070G Polymorphism NA 0.149 0.26 0 0.200 Q9Y4A5 S2433G Polymorphism 0.555 0.294 0.00 38 0.587 Q9Y4A5 W2139G Polymorphism NA 0.810 0.00 49 0.790 Q9Y4A8 V441E Polymorphism 0.225 0.212 0.01 -4 0.218 Q9Y4A9 G16R Polymorphism 0.902 0.921 0.00 75 0.932 Q9Y4B4 F1369L Polymorphism 0.168 0.148 0.72 21 0.121 Q9Y4B5 M593T Polymorphism 0.083 0.279 0.07 0 0.188 Q9Y4B5 G1088S Polymorphism 0.189 0.133 0.06 12 0.130 Q9Y4B5 K1202Q Polymorphism 0.290 0.049 0.13 7 0.114 Q9Y4B6 N267D Polymorphism 0.269 0.038 0.45 -23 0.048 Q9Y4B6 L1031P Polymorphism 0.881 0.816 0.01 51 0.921 Q9Y4C1 S447P Polymorphism 0.219 0.173 0.28 -11 0.125 Q9Y4C8 R921Q Polymorphism NA 0.309 0.41 28 0.365 Q9Y4D2 D945E Polymorphism NA 0.077 0.00 6 0.119 Q9Y4D2 G735V Polymorphism NA 0.226 0.00 34 0.209 Q9Y4D2 P889L Polymorphism NA 0.079 0.42 10 0.032 Q9Y4D7 L1412V Polymorphism 0.298 0.398 0.19 11 0.418 Q9Y4F1 P8L Polymorphism NA 0.105 0.05 -19 0.110 Q9Y4F4 E416Q Polymorphism 0.171 0.076 0.04 -28 0.050 Q9Y4F4 L511V Polymorphism 0.251 0.248 0.06 26 0.270 Q9Y4F9 E424K Polymorphism 0.355 0.122 0.34 10 0.123 Q9Y4F9 E495K Polymorphism 0.347 0.132 0.82 28 0.112 Q9Y4F9 V320M Polymorphism 0.206 0.255 0.11 7 0.304 Q9Y4G2 R377H Polymorphism NA 0.088 0.06 29 0.055 Q9Y4G6 V340A Polymorphism 0.531 0.414 0.00 28 0.613 Q9Y4G6 A1148S Polymorphism 0.095 0.109 0.56 -46 0.065 Q9Y4G6 T2144I Polymorphism 0.130 0.500 0.49 25 0.278 Q9Y4H2 G879S Polymorphism 0.432 0.198 1.00 21 0.195 Q9Y4H2 G882A Polymorphism 0.392 0.058 0.30 19 0.080 Q9Y4H2 G1057D Polymorphism 0.294 0.099 0.21 32 0.084 Q9Y4I1 R1246C Polymorphism 0.712 0.230 0.12 -5 0.478 Q9Y4I5 C223R Polymorphism 0.354 0.485 0.00 65 0.449 Q9Y4J8 P121L Disease 0.118 0.180 0.25 8 0.154 Q9Y4K0 M570L Polymorphism 0.124 0.164 0.50 20 0.118 Q9Y4K0 S308R Polymorphism 0.421 0.592 0.60 16 0.343 Q9Y4K0 S359W Polymorphism 0.816 0.252 0.01 50 0.542 Q9Y4K1 C491R Polymorphism NA 0.261 NA 16 0.110 Q9Y4K1 G267D Polymorphism NA 0.243 NA 27 0.149 Q9Y4K1 Q293P Polymorphism NA 0.054 NA -20 0.024 Q9Y4K1 E1196A Polymorphism NA 0.568 0.15 34 0.438 Q9Y4K1 L1096V Polymorphism NA 0.205 0.01 36 0.220 Q9Y4K4 H41Y Polymorphism 0.260 0.565 0.12 43 0.535 Q9Y4K4 A334T Polymorphism NA 0.146 0.57 26 0.244 Q9Y4K4 N473K Polymorphism 0.258 0.134 0.72 -30 0.056 Q9Y4K4 P407L Polymorphism NA 0.067 0.04 29 0.098 Q9Y4K4 T633M Polymorphism NA 0.654 0.00 -11 0.477 Q9Y4L5 G194R Polymorphism 0.210 0.739 0.22 6 0.378 Q9Y4P3 V345I Polymorphism NA 0.292 0.95 -8 0.171 Q9Y4R7 A689T Polymorphism 0.149 0.153 NA 13 0.045 Q9Y4R7 M502R Polymorphism 0.304 0.281 0.49 -15 0.157 Q9Y4R7 N418H Polymorphism 0.500 0.426 0.07 -2 0.277 Q9Y4U1 Q27R Disease NA 0.242 0.50 -13 0.197 Q9Y4U1 G147A Disease NA 0.696 0.00 41 0.771 Q9Y4U1 G147D Disease NA 0.778 0.00 57 0.840 Q9Y4U1 G156D Disease NA 0.872 0.00 44 0.679 Q9Y4U1 H122R Disease NA 0.714 0.00 33 0.753 Q9Y4U1 L116P Disease NA 0.810 0.00 47 0.816 Q9Y4U1 L193P Disease NA 0.876 0.00 59 0.897 Q9Y4U1 R161G Disease NA 0.761 0.00 63 0.859 Q9Y4U1 R161Q Disease NA 0.705 0.00 70 0.752 Q9Y4U1 R189S Disease NA 0.423 0.30 32 0.501 Q9Y4U1 R206P Disease NA 0.937 0.00 68 0.931 Q9Y4U1 R206W Disease NA 0.855 0.00 70 0.899 Q9Y4U1 S271G Polymorphism NA 0.113 0.00 35 0.197 Q9Y4U1 W157C Disease NA 0.916 0.07 65 0.916 Q9Y4U1 Y130H Disease NA 0.522 0.00 62 0.655 Q9Y4X3 L96F Polymorphism 0.449 0.125 0.20 21 0.073 Q9Y4Z2 R93L Disease 0.997 0.950 0.00 43 0.944 Q9Y4Z2 F199S Polymorphism 0.095 0.064 0.45 18 0.022 Q9Y4Z2 R107S Disease 0.850 0.926 0.00 39 0.893 Q9Y512 I345V Polymorphism 0.569 0.150 1.00 -9 0.111 Q9Y520 A235T Polymorphism NA 0.048 0.18 24 0.072 Q9Y520 E468G Polymorphism NA 0.274 0.13 43 0.460 Q9Y520 L1868R Polymorphism 0.482 0.458 0.30 29 0.271 Q9Y520 P1924R Polymorphism 0.703 0.215 0.09 48 0.335 Q9Y520 S1624C Polymorphism 0.555 0.181 0.07 10 0.197 Q9Y561 S694G Polymorphism NA 0.163 0.01 28 0.056 Q9Y566 A6V Polymorphism NA 0.079 NA 24 0.043 Q9Y566 V1504A Polymorphism NA 0.063 1.00 -17 0.028 Q9Y572 E260V Polymorphism 0.459 0.215 0.22 15 0.349 Q9Y572 T300M Polymorphism 0.203 0.334 0.10 -17 0.252 Q9Y585 G256C Polymorphism 0.795 0.707 0.14 1 0.767 Q9Y5B0 L755S Polymorphism 0.273 0.226 0.00 -9 0.355 Q9Y5B0 T340M Polymorphism 0.223 0.105 0.01 -9 0.102 Q9Y5E1 S174P Polymorphism 0.241 0.480 1.00 -23 0.224 Q9Y5E2 E120K Polymorphism 0.570 0.723 0.07 20 0.501 Q9Y5E2 E187K Polymorphism 0.223 0.818 0.01 44 0.483 Q9Y5E2 R716W Polymorphism 0.894 0.595 0.00 44 0.828 Q9Y5E3 H636Q Polymorphism 0.252 0.355 1.00 6 0.335 Q9Y5E3 L232F Polymorphism 0.571 0.647 0.05 41 0.659 Q9Y5E4 I156T Polymorphism 0.124 0.231 0.53 -17 0.117 Q9Y5E4 S720P Polymorphism 0.556 0.568 0.16 30 0.542 Q9Y5E5 A421T Polymorphism 0.320 0.403 1.00 -47 0.015 Q9Y5E5 K168R Polymorphism 0.168 0.524 0.22 -7 0.133 Q9Y5E5 T553A Polymorphism 0.337 0.587 1.00 -9 0.149 Q9Y5E6 K41R Polymorphism 0.110 0.233 0.36 -30 0.221 Q9Y5E6 E207K Polymorphism 0.448 0.754 0.36 11 0.351 Q9Y5E6 R414S Polymorphism 0.312 0.468 0.81 9 0.330 Q9Y5E7 G760D Polymorphism 0.113 0.553 0.92 -6 0.144 Q9Y5E7 L674P Polymorphism 0.390 0.628 0.63 -31 0.343 Q9Y5E7 V128I Polymorphism 0.208 0.500 1.00 -36 0.237 Q9Y5E8 S474R Polymorphism 0.662 0.665 0.13 31 0.673 Q9Y5F0 R471G Polymorphism 0.653 0.460 0.47 7 0.033 Q9Y5F2 R7H Polymorphism 0.199 0.522 0.19 -20 0.401 Q9Y5F3 L390F Polymorphism 0.640 0.628 0.04 37 0.710 Q9Y5F9 A722T Polymorphism 0.226 0.071 0.65 -36 0.105 Q9Y5F9 P684S Polymorphism 0.213 0.191 0.76 -18 0.194 Q9Y5G1 N389K Polymorphism 0.399 0.697 0.04 19 0.490 Q9Y5G2 P26R Polymorphism 0.181 0.639 0.35 0 0.227 Q9Y5G9 A150T Polymorphism 0.175 0.306 1.00 -17 0.221 Q9Y5G9 D683H Polymorphism 0.539 0.599 0.11 9 0.516 Q9Y5G9 R641K Polymorphism 0.266 0.663 0.19 -6 0.221 Q9Y5H0 I154L Polymorphism 0.690 0.334 1.00 -35 0.324 Q9Y5H1 Q5R Polymorphism 0.142 0.214 0.64 -62 0.173 Q9Y5H3 I89V Polymorphism 0.326 0.415 0.50 -31 0.162 Q9Y5H3 S796P Polymorphism 0.397 0.546 0.23 9 0.546 Q9Y5H5 S28R Polymorphism 0.390 0.849 0.12 12 0.526 Q9Y5H5 G430R Polymorphism 0.482 0.616 0.79 8 0.308 Q9Y5H5 K764T Polymorphism 0.179 0.132 0.59 -8 0.109 Q9Y5H5 L336V Polymorphism 0.343 0.369 1.00 -41 0.154 Q9Y5H6 K579E Polymorphism 0.405 0.480 1.00 -27 0.088 Q9Y5H6 N403T Polymorphism 0.749 0.520 0.00 55 0.823 Q9Y5H7 A691V Polymorphism 0.449 0.523 0.29 0 0.426 Q9Y5H8 I289T Polymorphism 0.261 0.160 0.26 1 0.216 Q9Y5H8 I318V Polymorphism 0.413 0.168 0.30 -1 0.243 Q9Y5H9 E25K Polymorphism 0.226 0.362 0.61 -4 0.267 Q9Y5H9 P764L Polymorphism 0.260 0.336 0.11 -30 0.330 Q9Y5H9 V106L Polymorphism 0.525 0.479 1.00 -47 0.260 Q9Y5I2 S439R Polymorphism 0.430 0.616 0.28 34 0.469 Q9Y5I2 V585G Polymorphism 0.351 0.404 0.29 13 0.040 Q9Y5I3 C759F Polymorphism 0.580 0.616 0.01 36 0.622 Q9Y5I3 N449H Polymorphism 0.998 0.738 0.00 71 0.973 Q9Y5I3 Y732C Polymorphism 0.304 0.265 0.23 6 0.302 Q9Y5I7 M71R Disease 0.178 0.709 0.00 52 0.775 Q9Y5I7 A209T Disease 0.322 0.609 0.10 49 0.634 Q9Y5I7 F232C Disease 0.741 0.659 0.01 57 0.861 Q9Y5I7 G191R Disease 0.637 0.906 0.00 72 0.916 Q9Y5I7 G198A Disease 0.392 0.672 0.08 20 0.517 Q9Y5I7 G198D Disease 0.558 0.806 0.00 60 0.892 Q9Y5I7 G233D Disease 0.997 0.923 0.00 76 0.967 Q9Y5I7 G239R Disease 0.637 0.918 0.00 65 0.920 Q9Y5I7 H141D Disease NA 0.277 1.00 55 0.248 Q9Y5I7 L145P Disease 0.705 0.729 0.00 64 0.897 Q9Y5I7 L151F Disease 0.385 0.252 0.01 33 0.392 Q9Y5I7 L151P Disease 0.705 0.845 0.00 52 0.886 Q9Y5I7 L151W Disease 0.787 0.625 0.00 41 0.746 Q9Y5I7 L167P Disease 0.705 0.870 0.00 53 0.886 Q9Y5I7 R149L Disease 0.472 0.867 0.00 60 0.903 Q9Y5I7 R216T Disease 0.470 0.694 0.21 50 0.825 Q9Y5I7 S235F Disease 0.611 0.532 0.00 55 0.836 Q9Y5I7 S235P Disease 0.497 0.710 0.01 69 0.876 Q9Y5J5 R28Q Polymorphism NA 0.186 0.06 28 0.332 Q9Y5K2 S22A Polymorphism NA 0.165 0.57 -71 0.133 Q9Y5K6 N581K Polymorphism 0.120 0.063 0.10 10 0.084 Q9Y5P6 H126D Polymorphism 0.246 0.492 0.44 3 0.245 Q9Y5P6 Q184R Polymorphism 0.247 0.512 0.13 -5 0.363 Q9Y5P8 A519V Polymorphism 0.155 0.238 0.51 -9 0.198 Q9Y5Q0 N216K Polymorphism 0.182 0.561 1.00 28 0.330 Q9Y5Q6 Q50L Polymorphism NA 0.019 0.11 -70 0.007 Q9Y5R4 R192Q Polymorphism 0.215 0.500 0.31 11 0.251 Q9Y5R6 Y221S Polymorphism 0.371 0.658 0.00 23 0.684 Q9Y5S2 R555Q Polymorphism 0.289 0.284 0.07 5 0.298 Q9Y5S2 R671Q Polymorphism 0.150 0.220 0.39 -9 0.194 Q9Y5S2 S1633Y Polymorphism 0.485 0.122 0.00 4 0.152 Q9Y5S8 R315H Polymorphism 0.561 0.457 0.07 12 0.522 Q9Y5S8 R378K Polymorphism 0.222 0.390 1.00 -23 0.308 Q9Y5T4 R35G Polymorphism 0.132 0.170 0.03 10 0.041 Q9Y5U2 H17P Polymorphism NA 0.117 0.12 0 0.106 Q9Y5U2 G262R Polymorphism NA 0.061 0.81 14 0.043 Q9Y5U2 R124Q Polymorphism NA 0.060 0.32 -4 0.040 Q9Y5U5 D83N Polymorphism 0.476 0.389 0.55 5 0.170 Q9Y5U8 L36I Polymorphism 0.088 0.149 0.35 -34 0.105 Q9Y5W3 R145P Polymorphism 0.612 0.152 0.00 62 0.183 Q9Y5W8 L472S Polymorphism 0.669 0.557 0.03 32 0.744 Q9Y5X4 G56R Disease 0.945 0.787 0.00 73 0.930 Q9Y5X4 G88V Disease 0.707 0.780 0.15 45 0.877 Q9Y5X4 R76Q Disease 0.816 0.277 0.89 22 0.624 Q9Y5X4 R76W Disease 0.968 0.865 0.22 47 0.909 Q9Y5X4 R97H Disease 0.995 0.875 0.00 74 0.942 Q9Y5X4 A256E Disease 0.565 0.611 0.26 46 0.788 Q9Y5X4 E121K Disease 0.842 0.352 0.15 41 0.671 Q9Y5X4 L263P Disease 0.936 0.916 0.00 67 0.935 Q9Y5X4 L336P Disease 0.861 0.933 0.01 37 0.877 Q9Y5X4 L353V Disease 0.671 0.775 0.00 24 0.763 Q9Y5X4 M407K Disease 0.713 0.914 0.00 56 0.909 Q9Y5X4 R104W Disease 0.999 0.906 0.00 76 0.946 Q9Y5X4 R309G Disease 0.600 0.537 0.10 42 0.680 Q9Y5X4 R311Q Disease 0.237 0.500 0.34 11 0.384 Q9Y5X4 R385P Disease 0.700 0.826 0.20 49 0.876 Q9Y5X4 V302I Polymorphism 0.083 0.027 0.40 -7 0.081 Q9Y5X4 W234S Disease 0.839 0.868 0.02 45 0.892 Q9Y5X9 T111I Polymorphism 0.189 0.710 0.09 -35 0.314 Q9Y5Y0 T544M Polymorphism NA 0.090 0.06 34 0.099 Q9Y5Y2 P250S Polymorphism 0.170 0.731 0.57 -11 0.296 Q9Y5Y3 L312F Polymorphism 0.198 0.883 0.07 43 0.463 Q9Y5Y5 V254L Polymorphism 0.228 0.119 0.48 -36 0.088 Q9Y5Y6 G827R Disease 0.994 0.918 0.00 76 0.948 Q9Y5Y6 R381S Polymorphism NA 0.411 0.64 51 0.495 Q9Y5Y7 V315M Polymorphism 0.516 0.119 0.00 41 0.098 Q9Y5Y9 G590R Polymorphism 0.276 0.247 0.34 15 0.316 Q9Y5Z4 E191A Polymorphism 0.824 0.923 0.00 44 0.890 Q9Y5Z4 R140Q Polymorphism 0.481 0.510 0.29 37 0.580 Q9Y5Z7 G268A Polymorphism 0.072 0.468 0.81 5 0.200 Q9Y5Z9 S75F Polymorphism 0.379 0.665 0.42 -3 0.459 Q9Y5Z9 D112G Disease 0.905 0.927 0.00 58 0.944 Q9Y5Z9 D118G Disease 0.138 0.310 0.74 32 0.274 Q9Y5Z9 D236E Disease 0.540 0.821 0.00 59 0.856 Q9Y5Z9 G177R Disease 0.787 0.929 0.06 9 0.856 Q9Y5Z9 G186R Disease 0.965 0.919 0.00 74 0.950 Q9Y5Z9 L121F Disease 0.578 0.412 0.07 26 0.640 Q9Y5Z9 N102S Disease 0.890 0.961 0.00 65 0.939 Q9Y5Z9 N232S Disease 0.384 0.920 0.00 57 0.854 Q9Y5Z9 R119G Disease 0.481 0.719 0.30 61 0.646 Q9Y5Z9 S171P Disease 0.713 0.859 0.16 35 0.862 Q9Y5Z9 T175I Disease 0.811 0.859 0.00 20 0.856 Q9Y603 A250V Polymorphism 0.198 0.638 0.19 39 0.507 Q9Y603 H138Y Polymorphism 0.090 0.234 0.41 48 0.293 Q9Y603 P212L Polymorphism 0.163 0.542 0.03 39 0.411 Q9Y615 R45C Polymorphism NA 0.097 0.01 55 0.148 Q9Y615 V340M Polymorphism 0.341 0.638 0.17 -29 0.470 Q9Y616 G84S Polymorphism NA 0.163 0.52 44 0.283 Q9Y616 H57R Polymorphism NA 0.051 0.83 37 0.068 Q9Y616 R384Q Polymorphism 0.182 0.135 0.05 43 0.190 Q9Y616 S288L Polymorphism 0.524 0.406 0.10 15 0.609 Q9Y617 D100A Disease 0.404 0.886 0.46 19 0.580 Q9Y618 G781E Polymorphism NA 0.217 1.00 -5 0.157 Q9Y618 A1707T Polymorphism NA 0.155 0.12 -33 0.151 Q9Y619 A70L Disease 0.633 0.757 0.02 24 0.812 Q9Y619 G27E Disease 0.087 0.866 0.00 53 0.204 Q9Y619 G27R Disease 0.370 0.872 0.00 69 0.921 Q9Y619 L71Q Disease 0.820 0.664 0.01 32 0.720 Q9Y619 M37R Disease 0.688 0.850 0.00 67 0.918 Q9Y619 E180K Disease 0.671 0.443 0.03 65 0.896 Q9Y619 F188L Disease 0.543 0.681 0.19 43 0.551 Q9Y619 G113C Disease 0.916 0.769 0.00 51 0.899 Q9Y619 G190D Disease 0.523 0.459 0.15 48 0.642 Q9Y619 G216S Disease 0.988 0.824 0.00 44 0.908 Q9Y619 L283F Disease 0.527 0.373 0.10 11 0.575 Q9Y619 M273K Disease 0.355 0.802 0.14 56 0.697 Q9Y619 P126R Disease 0.998 0.813 0.00 74 0.940 Q9Y619 R275Q Disease 0.986 0.822 0.00 69 0.927 Q9Y619 T272I Disease 0.702 0.341 0.49 18 0.587 Q9Y620 D97H Polymorphism NA 0.145 0.02 -12 0.149 Q9Y620 L30V Polymorphism NA 0.045 0.17 -36 0.028 Q9Y623 A594T Polymorphism 0.197 0.227 0.82 -48 0.161 Q9Y623 D1802G Polymorphism NA 0.837 0.16 19 0.639 Q9Y623 I1106M Polymorphism 0.124 0.224 0.23 -59 0.157 Q9Y623 R1862C Polymorphism NA 0.828 0.00 30 0.698 Q9Y625 V412M Polymorphism 0.094 0.278 0.78 11 0.171 Q9Y653 C91S Disease NA 0.270 0.00 38 0.318 Q9Y653 R38W Disease NA 0.343 0.00 61 0.536 Q9Y653 Y88C Disease NA 0.233 0.00 57 0.267 Q9Y653 C346S Disease 0.997 0.891 0.01 59 0.954 Q9Y653 P527L Polymorphism 0.998 0.858 0.00 0 0.927 Q9Y653 R565W Disease 0.839 0.703 0.08 20 0.807 Q9Y666 A408T Polymorphism NA 0.069 0.60 20 0.088 Q9Y672 A333V Disease 0.811 0.373 0.07 4 0.659 Q9Y672 F304S Polymorphism 0.403 0.119 0.27 0 0.254 Q9Y672 G227E Disease 0.357 0.274 1.00 -8 0.346 Q9Y672 K226N Polymorphism 0.321 0.230 0.61 -4 0.249 Q9Y672 S170I Disease 0.498 0.731 0.12 22 0.642 Q9Y672 S308R Disease 0.654 0.519 0.10 23 0.750 Q9Y672 S478P Disease 0.749 0.626 0.16 52 0.857 Q9Y672 Y131H Disease 0.764 0.301 0.01 28 0.619 Q9Y692 V14A Polymorphism NA 0.429 0.00 33 0.366 Q9Y694 R303K Polymorphism 0.078 0.205 0.98 -39 0.167 Q9Y6A1 G76R Disease NA 0.813 0.12 31 0.826 Q9Y6A1 A200P Disease NA 0.853 0.04 51 0.890 Q9Y6A1 S537R Disease 0.303 0.339 0.82 16 0.377 Q9Y6A1 V428D Disease 0.960 0.921 0.00 66 0.953 Q9Y6A5 G287S Polymorphism NA 0.038 0.80 -21 0.029 Q9Y6B6 D75G Disease 0.714 0.934 0.00 69 0.939 Q9Y6B6 G11D Disease 0.215 0.673 0.21 37 0.610 Q9Y6B6 G37R Disease 0.997 0.901 0.00 75 0.947 Q9Y6B6 D137N Disease 0.636 0.849 0.00 58 0.900 Q9Y6B6 S179R Disease 0.740 0.671 0.01 63 0.904 Q9Y6B7 L480S Polymorphism 0.140 0.500 0.34 -21 0.139 Q9Y6C2 Q149R Polymorphism 0.260 0.098 0.60 37 0.153 Q9Y6C5 E346Q Polymorphism 0.347 0.541 0.13 24 0.532 Q9Y6C5 T988M Polymorphism 0.760 0.540 0.04 18 0.752 Q9Y6C5 V995M Polymorphism 0.481 0.597 0.09 16 0.511 Q9Y6C5 I1121M Polymorphism 0.232 0.096 0.08 -23 0.176 Q9Y6C9 P290A Polymorphism 0.506 0.518 0.11 31 0.733 Q9Y6D5 A527V Polymorphism NA 0.373 0.21 -10 0.339 Q9Y6D5 E209K Disease NA 0.192 0.88 11 0.210 Q9Y6D9 E511K Polymorphism 0.377 0.282 0.48 36 0.368 Q9Y6D9 N160S Polymorphism 0.188 0.035 1.00 -51 0.054 Q9Y6D9 T500M Polymorphism 0.712 0.103 0.14 -2 0.246 Q9Y6E0 A414V Polymorphism 0.335 0.222 0.14 -9 0.229 Q9Y6E2 D44A Polymorphism 0.819 0.860 0.00 46 0.888 Q9Y6F1 H100R Polymorphism 0.721 0.307 0.84 23 0.338 Q9Y6F1 Q269R Polymorphism 0.323 0.148 0.59 -3 0.109 Q9Y6F6 A28T Polymorphism 0.096 0.169 1.00 8 0.055 Q9Y6F6 P186S Polymorphism 0.400 0.167 0.00 26 0.295 Q9Y6G9 Q277R Polymorphism 0.134 0.348 0.26 0 0.178 Q9Y6H6 T4A Polymorphism 0.070 0.043 0.16 -43 0.018 Q9Y6H6 P39R Polymorphism 0.463 0.083 0.05 31 0.074 Q9Y6H8 F32L Disease 0.992 0.936 0.00 9 0.750 Q9Y6H8 N63S Disease 0.935 0.902 0.02 43 0.910 Q9Y6H8 R76H Disease 0.798 0.936 0.00 50 0.892 Q9Y6H8 P187L Disease 0.833 0.885 0.01 33 0.846 Q9Y6I7 L16S Polymorphism 0.069 0.245 0.10 15 0.133 Q9Y6J0 A56T Polymorphism 0.242 0.140 NA 29 0.144 Q9Y6J0 D225N Polymorphism 0.143 0.096 NA -8 0.093 Q9Y6J0 Q921E Polymorphism 0.083 0.183 NA -25 0.114 Q9Y6J6 Q9E Disease 0.212 0.162 0.00 15 0.173 Q9Y6J6 T8I Polymorphism 0.304 0.488 0.00 48 0.641 Q9Y6J6 F60L Disease 0.254 0.766 0.00 43 0.711 Q9Y6J6 I57T Disease 0.435 0.711 0.01 26 0.709 Q9Y6J6 M54T Disease 0.415 0.708 0.01 42 0.733 Q9Y6J6 R27C Disease 0.702 0.486 0.00 69 0.853 Q9Y6J6 R77W Disease 0.844 0.365 0.04 36 0.439 Q9Y6J6 V65M Disease 0.479 0.233 0.02 37 0.309 Q9Y6K5 R18K Polymorphism NA 0.102 0.29 12 0.182 Q9Y6K5 R18M Polymorphism NA 0.084 0.21 30 0.156 Q9Y6K5 R18T Polymorphism NA 0.129 0.37 32 0.264 Q9Y6K5 R869H Polymorphism 0.819 0.787 0.04 44 0.758 Q9Y6K5 S381R Polymorphism NA 0.118 0.35 28 0.079 Q9Y6K8 R465Q Polymorphism 0.961 0.910 0.00 58 0.888 Q9Y6K9 E57K Disease NA 0.385 0.00 20 0.543 Q9Y6K9 A288G Disease NA 0.122 0.11 15 0.203 Q9Y6K9 A323P Disease NA 0.186 0.30 27 0.335 Q9Y6K9 C417F Disease NA 0.832 0.00 56 0.890 Q9Y6K9 C417R Disease NA 0.945 0.00 67 0.939 Q9Y6K9 C417Y Disease NA 0.952 0.00 58 0.929 Q9Y6K9 D311N Disease NA 0.576 0.00 49 0.724 Q9Y6K9 D406V Disease NA 0.830 0.02 63 0.901 Q9Y6K9 E315A Disease NA 0.539 0.00 30 0.722 Q9Y6K9 L153R Disease NA 0.896 0.01 42 0.804 Q9Y6K9 L227P Disease NA 0.867 0.01 58 0.891 Q9Y6K9 M407V Disease NA 0.229 0.10 44 0.394 Q9Y6K9 R123W Disease NA 0.083 0.02 29 0.122 Q9Y6K9 R173G Disease NA 0.422 0.06 31 0.500 Q9Y6K9 R175P Disease NA 0.718 0.27 45 0.793 Q9Y6K9 R319Q Disease NA 0.432 0.05 50 0.647 Q9Y6L6 D462G Polymorphism 0.367 0.366 0.59 7 0.321 Q9Y6L6 E667G Polymorphism 0.543 0.407 0.38 17 0.515 Q9Y6L6 L643F Polymorphism 0.109 0.279 0.02 -44 0.189 Q9Y6L6 N151S Polymorphism NA 0.162 0.62 0 0.150 Q9Y6L6 N432D Polymorphism 0.181 0.468 0.09 65 0.313 Q9Y6L6 P155T Polymorphism 0.424 0.198 0.16 -36 0.248 Q9Y6L6 R152K Polymorphism 0.082 0.298 0.55 -25 0.167 Q9Y6L6 V174A Polymorphism 0.808 0.687 0.01 -20 0.713 Q9Y6M0 R264Q Polymorphism 0.418 0.222 0.79 10 0.306 Q9Y6M9 P146S Polymorphism 0.125 0.060 0.00 -9 0.143 Q9Y6N5 I264T Polymorphism 0.517 0.532 0.75 -12 0.384 Q9Y6N6 P522S Polymorphism 0.059 0.378 0.75 0 0.238 Q9Y6N6 R770G Polymorphism 0.053 0.212 0.40 26 0.148 Q9Y6N6 R1264W Polymorphism 0.716 0.767 0.03 34 0.732 Q9Y6N6 S1082G Polymorphism 0.062 0.719 0.52 12 0.141 Q9Y6N7 V336A Polymorphism 0.368 0.201 1.00 -8 0.204 Q9Y6N7 S1091N Polymorphism 0.158 0.173 0.11 47 0.176 Q9Y6N8 S413F Polymorphism 0.546 0.382 0.08 -8 0.602 Q9Y6N9 E519D Polymorphism 0.116 0.128 0.04 22 0.127 Q9Y6P5 L44I Polymorphism 0.161 0.223 0.00 0 0.280 Q9Y6Q2 K8N Polymorphism NA 0.064 0.18 -30 0.007 Q9Y6Q2 Q544H Polymorphism 0.412 0.646 0.01 37 0.605 Q9Y6Q2 R127T Polymorphism NA 0.087 0.01 21 0.098 Q9Y6Q3 V7D Polymorphism NA 0.204 0.10 39 0.178 Q9Y6Q6 G53R Disease 0.998 0.937 0.00 72 0.956 Q9Y6Q6 A192V Polymorphism 0.056 0.282 0.10 -23 0.205 Q9Y6Q6 A244S Disease 0.130 0.146 0.03 27 0.122 Q9Y6Q6 C175R Disease 0.976 0.987 0.02 79 0.952 Q9Y6Q6 R129C Disease 0.781 0.524 0.04 46 0.788 Q9Y6Q6 R170G Disease 0.367 0.651 0.01 32 0.715 Q9Y6Q9 G460R Polymorphism 0.693 0.217 0.10 53 0.288 Q9Y6Q9 P559S Polymorphism 0.191 0.089 0.39 37 0.169 Q9Y6Q9 Q586H Polymorphism 0.412 0.076 0.79 45 0.175 Q9Y6Q9 S777A Polymorphism 0.255 0.090 0.28 6 0.161 Q9Y6R1 A843V Disease 0.836 0.939 0.01 30 0.891 Q9Y6R1 R342S Disease 0.983 0.975 0.00 48 0.939 Q9Y6R1 R554H Disease 0.988 0.918 0.01 57 0.950 Q9Y6R1 R925C Disease 0.971 0.916 0.00 54 0.950 Q9Y6R1 S471L Disease 0.616 0.887 0.01 -5 0.865 Q9Y6R1 T529S Disease 0.779 0.840 0.56 24 0.763 Q9Y6R4 R566H Polymorphism NA 0.086 NA 18 0.060 Q9Y6R4 V335I Polymorphism NA 0.099 NA 29 0.092 Q9Y6R7 G929R Polymorphism 0.444 0.345 0.12 34 0.429 Q9Y6R7 N770S Polymorphism 0.135 0.229 0.47 2 0.158 Q9Y6R7 A2793V Polymorphism NA 0.500 0.28 34 0.254 Q9Y6R7 E2646D Polymorphism NA 0.500 1.00 31 0.388 Q9Y6R7 E2647K Polymorphism NA 0.635 0.08 54 0.448 Q9Y6R7 G1019R Polymorphism 0.117 0.244 0.00 66 0.335 Q9Y6R7 G1616V Polymorphism NA 0.650 0.86 46 0.394 Q9Y6R7 H1445D Polymorphism 0.087 0.552 1.00 20 0.051 Q9Y6R7 M1617V Polymorphism NA 0.648 0.50 6 0.262 Q9Y6R7 N2089D Polymorphism NA 0.419 0.77 52 0.330 Q9Y6R7 T1524N Polymorphism NA 0.335 0.56 -3 0.256 Q9Y6R7 V1340L Polymorphism 0.153 0.433 0.65 6 0.223 Q9Y6R7 V2814A Polymorphism NA 0.485 0.72 27 0.146 Q9Y6S9 R21Q Polymorphism NA 0.158 0.00 27 0.212 Q9Y6S9 P121L Polymorphism 0.154 0.067 0.09 0 0.117 Q9Y6S9 R332W Polymorphism 0.736 0.181 0.01 47 0.284 Q9Y6U3 F455L Polymorphism 0.161 0.353 0.49 -25 0.197 Q9Y6U3 K500R Polymorphism 0.139 0.214 1.00 -54 0.173 Q9Y6U7 A322T Polymorphism NA 0.213 0.39 -26 0.204 Q9Y6V0 A2735T Polymorphism NA 0.084 1.00 0 0.088 Q9Y6V7 R413W Polymorphism 0.401 0.879 0.00 53 0.886 Q9Y6X2 S390C Polymorphism 0.817 0.426 0.05 -18 0.640 Q9Y6X5 H144Q Polymorphism 0.283 0.511 0.33 -6 0.296 Q9Y6X6 M385T Polymorphism 0.248 0.122 0.32 16 0.105 Q9Y6X6 P831A Polymorphism 0.093 0.257 0.56 12 0.163 Q9Y6X6 V339I Polymorphism NA 0.082 0.16 11 0.107 Q9Y6X8 R649K Polymorphism 0.322 0.500 0.16 -27 0.459 Q9Y6X8 V357M Polymorphism 0.560 0.063 0.13 -7 0.037 Q9Y6Y1 N1177K Polymorphism 0.123 0.093 0.01 48 0.126 Q9Y6Y1 N1218T Polymorphism 0.215 0.296 NA 48 0.182 Q9Y6Y9 P157S Polymorphism NA 0.080 0.54 16 0.045 Q9Y6Z4 H23D Polymorphism NA 0.636 NA 36 0.461 Q9Y6Z4 Q57E Polymorphism NA 0.119 NA 14 0.038